[med-svn] [python-freecontact] 01/10: Imported Upstream version 1.0
Laszlo Kajan
lkajan at alioth.debian.org
Thu Sep 19 17:37:19 UTC 2013
This is an automated email from the git hooks/post-receive script.
lkajan pushed a commit to branch master
in repository python-freecontact.
commit dee27844525d59a0f69303a5ceaa8e73dbb6fbcd
Author: Laszlo Kajan <lkajan at debian.org>
Date: Wed Jul 17 20:07:20 2013 +0200
Imported Upstream version 1.0
---
COPYING | 639 +++++++++++++++++++++++++++++++
Changes | 4 +
PKG-INFO | 10 +
README | 15 +
examples/demo_1000.aln | 1000 ++++++++++++++++++++++++++++++++++++++++++++++++
setup.py | 36 ++
src/freecontact.cpp | 364 ++++++++++++++++++
test/test01.py | 88 +++++
8 files changed, 2156 insertions(+)
diff --git a/COPYING b/COPYING
new file mode 100644
index 0000000..1276ee5
--- /dev/null
+++ b/COPYING
@@ -0,0 +1,639 @@
+FreeContact - program to predict protein residue contacts from a sufficiently large multiple alignment
+Copyright (C) 2012-2013 Laszlo Kajan <lkajan at rostlab.org> Rost Lab, Technical University of Munich, Germany
+
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+author or copyright holder as a result of your choosing to follow a
+later version.
+
+ 15. Disclaimer of Warranty.
+
+ THERE IS NO WARRANTY FOR THE PROGRAM, TO THE EXTENT PERMITTED BY
+APPLICABLE LAW. EXCEPT WHEN OTHERWISE STATED IN WRITING THE COPYRIGHT
+HOLDERS AND/OR OTHER PARTIES PROVIDE THE PROGRAM "AS IS" WITHOUT WARRANTY
+OF ANY KIND, EITHER EXPRESSED OR IMPLIED, INCLUDING, BUT NOT LIMITED TO,
+THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR
+PURPOSE. THE ENTIRE RISK AS TO THE QUALITY AND PERFORMANCE OF THE PROGRAM
+IS WITH YOU. SHOULD THE PROGRAM PROVE DEFECTIVE, YOU ASSUME THE COST OF
+ALL NECESSARY SERVICING, REPAIR OR CORRECTION.
+
+ 16. Limitation of Liability.
+
+ IN NO EVENT UNLESS REQUIRED BY APPLICABLE LAW OR AGREED TO IN WRITING
+WILL ANY COPYRIGHT HOLDER, OR ANY OTHER PARTY WHO MODIFIES AND/OR CONVEYS
+THE PROGRAM AS PERMITTED ABOVE, BE LIABLE TO YOU FOR DAMAGES, INCLUDING ANY
+GENERAL, SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES ARISING OUT OF THE
+USE OR INABILITY TO USE THE PROGRAM (INCLUDING BUT NOT LIMITED TO LOSS OF
+DATA OR DATA BEING RENDERED INACCURATE OR LOSSES SUSTAINED BY YOU OR THIRD
+PARTIES OR A FAILURE OF THE PROGRAM TO OPERATE WITH ANY OTHER PROGRAMS),
+EVEN IF SUCH HOLDER OR OTHER PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF
+SUCH DAMAGES.
+
+ 17. Interpretation of Sections 15 and 16.
+
+ If the disclaimer of warranty and limitation of liability provided
+above cannot be given local legal effect according to their terms,
+reviewing courts shall apply local law that most closely approximates
+an absolute waiver of all civil liability in connection with the
+Program, unless a warranty or assumption of liability accompanies a
+copy of the Program in return for a fee.
+
+ END OF TERMS AND CONDITIONS
diff --git a/Changes b/Changes
new file mode 100644
index 0000000..5e0b69b
--- /dev/null
+++ b/Changes
@@ -0,0 +1,4 @@
+Revision history for Python module freecontact.
+
+1.0 Wed Jul 17 18:27:02 CEST 2013
+ - original version
diff --git a/PKG-INFO b/PKG-INFO
new file mode 100644
index 0000000..d08c238
--- /dev/null
+++ b/PKG-INFO
@@ -0,0 +1,10 @@
+Metadata-Version: 1.0
+Name: python-freecontact
+Version: 1.0
+Summary: fast protein contact predictor
+Home-page: http://rostlab.org/
+Author: Laszlo Kajan
+Author-email: lkajan at rostlab.org
+License: GPL-3+
+Description: UNKNOWN
+Platform: UNKNOWN
diff --git a/README b/README
new file mode 100644
index 0000000..edb5ccb
--- /dev/null
+++ b/README
@@ -0,0 +1,15 @@
+FreeContact - program to predict protein residue contacts from a sufficiently large multiple alignment
+Copyright (C) 2012-2013 Laszlo Kajan <lkajan at rostlab.org> Rost Lab, Technical University of Munich, Germany
+
+This program is free software: you can redistribute it and/or modify
+it under the terms of the GNU General Public License as published by
+the Free Software Foundation, either version 3 of the License, or
+(at your option) any later version.
+
+This program is distributed in the hope that it will be useful,
+but WITHOUT ANY WARRANTY; without even the implied warranty of
+MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
+GNU General Public License for more details.
+
+You should have received a copy of the GNU General Public License
+along with this program. If not, see <http://www.gnu.org/licenses/>.
diff --git a/examples/demo_1000.aln b/examples/demo_1000.aln
new file mode 100644
index 0000000..348b6f0
--- /dev/null
+++ b/examples/demo_1000.aln
@@ -0,0 +1,1000 @@
+ADKELKFLVVDDFSTMRRIVRNLLKELGFNNVEEAEDGVDALNKLQAGGYGFVISDWNMPNMDGLELLKTIRAAMSALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEKLGM
+-----TVLIAEDEMIEREFLVNLLNRLDFHVVAEAGDGQTAVELAFLHRPDVAFLDIRMPLLDGLAAAGKIKKALPQTFIVLNSAFAEFKYAQQGIDCGVDAYLLKPSSESEIFSLLRS-------
+-----TVLIAEDDVSVRGLVDSLLRKYGYQ-VVLAVDGGDCVRKFLEHRIDLILMDVIMPGKNGREAFDEIRRIDPSVRVLYSSGYTADFMKNRGVFEESVDLIMKPVQPMALLQKVREVLDRKG-
+-----TVLIAEDDLHVLDLVSSILQQYGYS-IIPAANGLEAVQKFKENQIKLVLMDIIMPVMNGKEAAECIRELRHDARILFTSGYTADIIRSRSDLDEGAELVMKPVKPPVLLQKIREMLDR---
+-----TVLIAEDDGDIIEILSLYLGGSGYE-VRAARNGADALEILRREQVAVALVDIMMPKMNGYDLIKAARAE-SQVPIIIISARAEAADKIIGLDAGADGYITKPFDPLEVTAYIRAVLRRG--
+-----TVLIAEDDAALLEVARRILSRNGYE-VLAASTALDACSIAIEHRIHLLLTDVIMPRMQGRELANRIRAQQPGIRVLYMSGYADPVLTAQGKLDPGVSLLTKPFSERTLLDKVRQVLD----
+-----TVLIADQHPVIAESIKYILETNDFIVIGQVLTGKELFKYLENRAPDVLMIEIDLPQLNGIHALRQIKQQYPHIKILVFSCHPEEMYALSAIKAGAAGYISKTNPADIVYKAIKQVTR----
+-----TVLIADDSRFTRNLLKKLLTDNGYQVVAEASDGNNAISLYQEKTPDIVILDLIMPIMNGLDALKSILKFDPEAKVIICSSMGQKSFIIDALQIGAKDFIIKPY-FNELIPALNKLF-----
+-----TVLIADDQPMQRFGSRMLLEQDDMTVVGEAANGNEAVGLVARHRPDVVLMDIRMPGLDGIEATRRIIASGAGTRILIVTTFDLDEYAYDGLRAGASGFLVKDALPEELLAGIRAVA-----
+-----TVLIADDQPMQRFGFRMLLEQDDMTVVGEASNGTEAVRLVDRHHPDVVLMDIRMPGLDGIEATRRIITTGARTRVLIVTTFDLDEYAYDGLRAGASGFLVKDAQPEELLAGIRAVA-----
+-----TVLIADDQPLQRMGFRMLMETPGLSPIGEAEHGAEAVRLAEQLRPDVVLMDIRMPGMDGLEATRRIVAAGGRTRVLIVTTFDLDEYAYEGLRAGASGFLLKDARPEELVAGIHAVA-----
+-----TVLIADDQPLQRLGFRMLLETPGLTPVGEAEHGGEAVRLAAQLRPDVVLMDIRMPGMDGLEATRRIVAAGGRTRVLIVTTFDLDEYAYDGLRAGASGFLLKDARPEELVAGIHAVA-----
+-----TVLIADDQPLQRLGFGMLLQTPGLTAVGEAEHGAEAVRLAAELRPDVVLMDIRMPGMDGLEATRRIVATGGRTRVLIVTTFDLDAYAYEGLRAGASGFLLKDARPEEIVAGIHAVA-----
+-----TVLIADDQPLQRFGSRMLLEQDDMTVVGEAANGSEAVRLAAELHPDVVLMDIRMPGLDGIEATRRITAAGDRTRILIVTTFDLDEYAYAGLRAGASGFLVKDAQPEELLSGIRAVA-----
+-----TVLIADDQPLQRFGFRMLLEQDDMTVVGEAANGAEAARMAAELHPDVVLMDVRMPGLDGIEATRRIVAGGGRSRVLILTTFDLDEYAYSGLRAGASGFLVKDALPEELLSGIRAVA-----
+-----TVLIADDQPLQRFGFRMLLEQDDMTVLGEAANGTEAIRMTAELHPDVVLMDIRMPGLDGIEATRRIVATGDRTRVLILTTFDLDEYAYAGLRAGASGFLVKDVRPEELLSGIRAVA-----
+-----TVLIADDQPLQRFGFRMLLEQDDLTVLGEAANGAEAIRMTAELSPDVVLMDVRMPGLDGIEATRRIVATGDRTRVLILTTFDLDEYAYAGLRAGASGFLVKDAQPEELLSGIRSVA-----
+-----TVLIADDNSDMRAFLKSVLSRY-YN-VVEAVDGQQAYQLAKLNRPDILVSDVMMPGMDGFELLRRLKADTAGMSVILLSARAGSESRIEGLAEGADDYLVKPFEAKELVARVNTHLQ----
+-----TVLIADDNIINIQILNRRLTKFGHK-VLVSRDGQECYNMFAANQTDFILMDLNMPVVDGWASVKMIRDR-PRVPVFAISGMLRRGDEQRYKDVGFDGWMPKPIDMKRLSTYLTGAV-----
+-----TVLIADDEPSFVEALVLGLTREGFE-TIVANDGEEALALSRSHHPDLILLDVMLPRLSGLDVCRTIRQE-SSVPIIMVTARSGELDTVLGLELGADDYVTKPFRMSELVARIRAQMRRT--
+-----TVLIADDDTAIRTVLNQALARAGFA-PRATGNAATLWRWVSQGEGDVVITDVVMPDENAFDLIPRIKKLRPDLPIIVMSAQNTLMTALTATEKGAFEYLPKPFDLNEVVAVISRALSE---
+-----TVLIADDDRTIRTVLTQALTRAGCR-VHATGSLSQLLRWVEEGRGDLVVTDVMMPDGNGIDMIPAIRKARPDLPVIVISAQNTIVTAIRATEAAAFDYLPKPFDLPDLMARAGQALSRR--
+-----TVLIADDDRAIRESLERALQLEGYQ-TRTAADGVETLAAVHSDPVDLLILDVMMPGVDGLGVCRVLRAEGDRTPILMLTARVETSDRVAGLDAGADDYLPKPFELDELLARIRALLRRA--
+-----TVLIADDDPNLRFLLSDMLQRAGFD-VLVAEDGSALLQIAQEQLPDIILVDLMLPGVDGYEAIRQLRNRTAHLPIIIVTARTNPADVVIGFDTGADDYVTKPFNEAELIARIRSLLRRTT-
+-----TVLIADDDPALLTYLQQLLQPWGWQ-LTVCKRGEQFWEILESSQPDLIILDADLPGYNGFELCRALRSDWINQPILILAERYDSELVQQALRYGADDVITKPIASSELVARIYNRLEK---
+-----TVLIADDDKLTREMLKEILVSNGFR-VLLAADGMEAYKEIVASRPQVVLTDKEMPNFDGFQLIKLVKADLKSIPIILISDKTTDDDEARLFELGFFDFMSKPIKAVTLVSRVKRAMS----
+-----TVLHIEESEFFCNIVKNTLVQGNYS-YISADNFNEAYKILQDSDIDIIITSLYAKGGSIENFLKDINYSKKDIPIFVVTSNAIDETKKKLLNLGVTDYILKKDLNEQIIQRIDSIFQS---
+-----TVLFVDDSRTARKAIKYTLLKLGFD-VVEAVDGKDGLEKLEKKHLKLIVSDVEMPKMDGYHFFSKIQERFANIPVIFNSSICDDYSAQKALDLGAKGYLVK-FDANRFIDEVSRVL-----
+-----TVLFVDDEQTVLEIGSEMLKELGFE-VATAADGGEALDIFKQDRFSFIILDLTMPRLDGEQTYRQLRQLKPEVKVIMSSGYNEQEINQRLGGTGLAGFIQKPYNLSMLRDVIRN-------
+-----TVLFVDDEQTVLDIGSEMLKELGFD-VVTAMDGSEALELFKQERYSFIILDLTMPRLDGEQTYRQMRELKPEVKVIMSSGYNEQEINQRLGGTELAGFVQKPYNLSTLRDVIKN-------
+-----TVLFVDDEKSYLAYTSELFVNRGLN-ILTAASALEALEIVEHQSVAVVVSDNEMPGMRGIELLSRIKDISPHTVKIMMTGSADLATTLAAINSGVFRFVLKPWKKAEMMRAVKDGIRRY--
+-----TVLFVDDEEMLLSNGSAMLHACGYE-VTTASSGKNAMELLRKDRYDIAVVDIIMPEFSGLECLKAIQKEVPSLPVILTSGNSGDEQISEGIEAGAAAFLPKPYSIETLSSLIADTLK----
+-----TVLFVDDEEELRIAVAQSLMLADLP-AEVYERAEDALAKISRSFQGVLVTDIRMPGNDGLWLMHQILEIDPEFPVILVTGHGDVDLAVRSMREGAYDFIEKPYPPARLVSTVQHALEKR--
+-----TVLFVDDEEELRHATRQTLMLADIP-ATILDKAELALAQISRGFPGVLVTDIRMPGNDGLWLMRKALEVDPEFPVILVTGHGDVNLAVSSMREGAYDFVEKPFAPSRLVSTIQRALDKR--
+-----TVLFIVDEPSVRMLIIDLLTEMGYA-AVQATDDVAGLKVLQFARIDMLVTDVGLPGMNGLQMADAARAHRPELKVLFITGYAECADIDDGRLGSGMQVLAKPFALDALGMRIKDLV-----
+-----TVLFIEDEPALGMIVKDSLTYRGFE-VLYAANGVEGLEQFRLHRPDIVVADIMMPDMDGFTMAEHIRRDDPHVPIMFLTARSQTADVVRGFELGGNDYLKKPFSLEELIVRINALLRA---
+-----TVLFAEDHADNRRFISRYLRSLGLD-VIAVENGEQAVERCLQDYPDLVLLDIQMPIMDGRAAFELLKKCGFQRPIFALTANAMSHEIDDYLTLGFDGYLAKPLDKDLFYKTLSENLDQ---
+-----TVLFADDDPHIRTLLSDTLTQAGFA-VLAAEDGLSLIRIAQEQLPDIILVDLMLPGVDGYEAIRQLRNRTAHLPIIIVTARANPSDVVIGFDTGADDYITKPFNEAELVARIRSLLRRIT-
+-----TVLCVDTPDRVSTVTDAVAAGDDLN-AVSATSVSDATEVLIDDPVVCVVTAYDLSDGTGLDIVGAIREHAPQTPCVLFTDASPGEIDTAAFEETIVEYLNRDLADERLSFVVDD-------
+-----TVLCVDTDARISTVSTAVETEDNLT-AIEARSVEDALDVIGSEPVVGVVTAYDLADGTGMDVIQAVREQTPQTPVVLFTDVSPAEIDTNSVEEVLVEYLNRDI------------------
+-----TVLCIDDEPAILRLLSVVLAADGHE-VMTATAGREALTIIGRGAVDAVLLDLGLADRDGLELIPAIRAI-TAVPILVISARGEVAEKVTALDLGAADYITKPFDGDEVRARLRVALRQ---
+-----TVLAVDDSPVMHGLVKQALGN-DYR-VLVTDNAVEALSLLYQEKVSILLLDVTMPEIDGLELCRTVRNQFQTLPIIMLTARDGAFEKVQGRLAGATEYLTKPFNPQTLSEVITQVLS----
+-----TVLAVDDSPSVRCMVAMTLREAGYR-VIEATDGREGLEKALSEPVDAIITDQNMPNLDGLGFIRAFREESKGKPIIFLSTDSADTLKQQAREAGAMGWMVKPFTQPQLLAVIKKVL-----
+-----TVLAVDDSPSIRQMVGLTLRGAGYN-VIEAVDGQDALEKATTLKIDAVLTDQNMPNLDGLGFIRAFRASSQGIPVIFLSTDSADALKQEARSVGALGWMVKPFSQAQLLSVIQKVL-----
+-----TVLAVDDSPSIRQMIKVVLGPAGHT-VIEAGDGAEGLAKARSESVNLVITDLNMPVMNGLEMIKQLRTSFTGVPILFLSTESDEGIKQQAKAAGATGWITKPFKPEQLLAVVGKLVR----
+-----TVLAVDDSKSILQMVSFTLKGAGYQ-VIEAGNGQEALAAAQKHKVDLVLTDLNMPVMDGLTLVQKLRATYKFTPILMLTTEAGADFKAKGKAAGLTGWLVKPFDPQKLLGVVKKVL-----
+-----TVLAVDDSASIRQMVSFTLKSAGYD-VVEAVDGMDGLEKAKTKSVNLILTDQNMPRMDGLTLIKNLRGQYASTPILMLTTESSDAMKSQGRAAGATGWLVKPFDPQKLIEVVRKVI-----
+-----TVLAVDDSAFIRKLIEKTLITAGYR-VISANDGAEAYDMLMGDHVSLIISDVEMPRMDGMHLVKRLRERYVKLPVIMFSSIMSEENRRKALLVGADDTVTKP-EIGTLVEMVDRY------
+-----TVLAVDDEPNILAALRRLFRATGWR-ILTAAHAEEALALLAAEPVDAVLSDMRMPGMDGVQFLERVSQGWPRTARLLLTGQADLGSTIAAINRGLHRYITKPWNDEELVLTLRQVAQNQ--
+-----TVLAVDDDIDILRMLNRYFAARTFN-LITAESGAGVVQRLT-NNPDLILLDVNLPDTDGFSLAERIRAI-TSVPIIFLTARVTDEDKVRGLGAGGDDYVTKPFSLAELGARIKAHFRRE--
+-----TVLAVDDDIDILRMLNRYFAARTFN-LITAESGAGAVQRLT-NNPDLILLDVNLPDTDGFSLAERIRAI-TSVPIIFLTARVTDEDKVRGLGAGGDDYVTKPFSLAELGARIKAHFRRE--
+-----TVLAVDDDIDILRMLNRYFAARTFN-LITAESGAGALQRLT-NNPDLILLDVNLPDTDGFSLAERIRAI-TLVPIIFLTARVTDEDKVRGLGAGGDDYVTKPFSLAELGARIKAHFRRE--
+-----TVLAVDDDARNLFALSGILELHGLR-VLHAENGRKGIDILTAHPIRLVLMDVMMPEMDGYAATAEIRKEYHDLPIVAVTAKAMPGDREKSLASGASDYVTKPVDAGDLIACVRRWLS----
+-----TVLAIDDSLTTRQTLSTTLQKAGYR-VIQAQDGADGLNQLELHPVVGIICDVEMPNMNGFEFLGRCRKKKAELPVLMLTSRGSKRYRQLAQQLGANGYLTKPYLDQELIETLQGAIAET--
+-------------------------------TVLAADGVDALELLGGFTPDLMICDIAMPRMNGLKLLEHIRNRGDQTPVLVISATENMADIAKALRLGVEDVLLKPVKLNRLREMVFA-------
+---TVKVVLLDDEELVRKGIRMVLHEPDIEVVAEGDDGSVAVDLVAEHRPDVVLTDIQMPRVGGLEVARRLAALPDPPAVAALTTFDVDEYVYAALQHGAAGFLLKDTSPRELADAVRVLAR----
+---TVKVLVVDDSSFFRRRVSEIINDPRLEVIGNAVNGKEAVELVQKLQPDVITMDIEMPVMDGITAVREIMKV-LPTPILMFSSLTQEKATLDALDAGALDFLPKKFE-----------------
+---TVKVLVVDDSSFFRRRVSEIINDPRLEVIGNAVNGKEAVELVKKLQPDVITMDIEMPVMDGITAVREIMKV-LPTPILMFSSLTQEKATLDALDAGALDFLPKKFE-----------------
+---TVKVLVVDDSAFFRRRVTEILENTNIKVIGSANNGEEAVEQSRTLKPDVITMDIEMPVMNGIDAVKAIMSS-NPCPILMFSSLTHETATLNALEAGAADFLPKKFE-----------------
+---TVKVLMVDDHPLFRQGVRWALSERDIKIIGEGSSAEEGLVLISEHEPDVVLTDLNLPNMDGLEFTRTIRRQYPNIGVVMLSVYESDEHAFNALRAGAAAYYSKEISPKTLATVLRRVAR----
+---TVKVLIVDDSPTMRAILSMMISDPEIEVVGKADCPSTARQMIKELNPDVMTLDIEMPGMDGLDFLEKVMRL-RPMPVIMVSALTAAEATLKAMELGAFDCFAKPA------------------
+---TVKVLIVDDSAVVRQVLTEQLAIAGITVMGAARDPLFARKLLETQWPDVIVLDIEMPRMDGLTFLRQLMAE-RPTPVIICSTLTEQEITMQAMSAGAVDIIAKPIGLRQFLEE----------
+---TVKVLIVDDSALMRKLFTQLFEKEGFI-VQVARNGEEALTKAVEFEPDCITLDINMPVMDGMTCLAMLKKL-YPCPIIMVSSLTQKSITLEALALGASDFVLK--------------------
+---TVKVLIVDARPERSRALEQALHEAGFDVVTRVDEHDDLYAIMTREVPDAVIIDAALPSRDTLEHMGQLGRRFPK-PMIMLAEEETPELTREATSVGVSAYVVEDVQPALVRSMVNVAIA----
+---TVKLLVVDDERPVLDAIKRAFKPYTAQELQSTSSGVEALLLVSEQKPHGMLIDLNMPDIDGLEVCRRIRAQMESVRLITMTSNHSPEVVEQSKQAGAIACLAKPLDVQQVLELF---------
+---TVKLLIVDDHPLFRQGVRWALSEPGIQIVGEAANGEEALRWLAQSEPNVMLVDLNLPGMSGLELTRQIRRQYTSIAVVMLSMHENDEAAFNALRAGAAAYRSKDIKPAALADILRRVAH----
+---TVKIVVVDDQAMVRSGFVALLSQPDIEVVGTAADGSEALQVVRRTHPDVVLMDVRMPVMDGIEALRQLSEATAQTKVVMLTTFDADEYVHESLRLGASGFLLKDASPDELASAIRVV------
+---TVKILLAEDDNDMRRFLVKALEKAGYK-VLSYDNGASAYDRLREEPFSLLLTDIVMPEMDGIELARRATELDPDLKVMFITGFAAVALNPDSKAPKDAKVLSKPFHLRDLVNEVNKMLA----
+---TVKILIADDQVLLSRALATILGQPDLEVVATVHDGQAAVDTVAHTPVDLVLMDVRMPKLDGVAALKKIRAKPNPPKIVMLTTFNVPDTVKAALTAGANGFLLKDADPETLIESVRTVAA----
+---TVKILIADDQVLLSRALATILGQPDLEVVATVHDGQAAVDTVAHTPVDLILMDVRMPKLDGVAALKKIRAKPNPPKIVMLTTFNVPDTVKAALTAGANGFLLKDADPETLIESVRTVAA----
+---TVKIAIIDDHQLFREGVKRILEEKTFEVVAEGEDGEEALDIIEKYHPDVVLMDINMPHQNGVEATRKLIEAYPETKIIILSIHDDESYVTHALKSGATGYLLKEMDSDALIEAVKVVA-----
+-----TVIVVEDDPTLQALLVEILIELGAT-CDAFDNSEDALIHLMGSDCSLIVVDHGVPSIKGMEFISMAHERWPGLPAILTSGYQLD----ASQVTPPVTYLFKPWSIDELTQAIGQALH----
+-----TVIVVDDSLFMRTVLKDILLDLGHAVIAEAENGYDAVLKYAHFRPDLITMDINMPKMDGLEAVKKIVELDPQANILMCSALGQQEAIIKAFKAGAKDFIVKPFEMERVVNAVTKLLD----
+-----TVIVVDDQHSHREMISNLLKGSGIN-VIEASDGVEAIEKIEVNCPDLIILDIVMPGMNGFEVCRRLKNLTQNIPIVFCSVKGEEFDRYWGIKQGADAYIAKPFGPRELVGTVKQFLR----
+-----TVIVVDDQALIRTAVRDLLDAEGISVVGEAADGEAGVDLARRLRPDVVVSDIRMPRRDGIELTALVCDALTETRVLILTTFEEDDYVVAALRAGASGFIGKGAEPEDIVRAVLSV------
+-----TVIVIEDDPTLRTLLVEILSELGAA-CAAFDNAEDALISMMSDECSLIVVDHGVPSIQGMEFISMAHERWPGLPAILTSGYQLDA----SQVTPPVIYLFKPWSIDQLADAICKALSAA--
+-----TVIVIDDDEMMRDSIDGLLRSVGIA-TRVFPSAVAALAEVWPTGPSCMVVDIRMPHLGGLELQERLNETGKTVPVIFITGHGDIPMTVKAMKAGAVDFLTKPFREQDLLEAVHIALDRA--
+-----TVILVEDDSAIAEPLARALSREGYD-VRSHDTGAAALTEVEA--ADLFILDLGLPDMDGLDVARHVRKLGKTTPILILTARADEIDMVVGLDAGADDYVTKPFRLAELLARVRALLRRIG-
+-----TVILVDDSRTILASAELALEDIQIH-FLTYSNPQQFLDEVFAGSYDLLISDINMPQVSGLEVSARLKQRFKSKPILILTTESSAEMKEKGKAIGVTGWMVKPFSDEKLVKSIKLV------
+----TVILTVDDDPGVSRVIARDLRRRGYR-IVRAESGESALEALRELKVAVILADYRMPRMNGIEFLEQALNVYPGARRVLLTAYADTGAAIDAINVDLDHYLLKPWDPPE--------------
+----TVILTVDDDPGVSRAVARDLRRRGYR-IVRAESGESALEALRELKVAVILADYRMPQMNGIEFLEQALTVYPGARRVLLTAYADTNAAIDAINVDLDHYLLKPWDPPE--------------
+----TVILLVEDNVINLKVLVHSMKKLKEE-YDTASNGLQAFEKYKKAPFKIIIMDISMPIMDGLTSTRHIREGLSRVRIVALTCFGTEEHRRDAAMSGVDLFLTKPIHLKSLKPVV---------
+-----TVILIDDDSDVLHSCAQSLELAGLR-VETSERADAVVKWLGPDTNGIVVTDIRMPGLDGIALLRAVQTADRDLPVILMTGHGDVPLAVEAMRAGAYDFLEKPFDPAQLVLTVTHALEKR--
+-----TVIIVEDEVEVAHLVAQYLFTSRYKVIGMASDINTARSLLGAITPDLLLLDVYLPDGNGLNLLAELRSQGICSEVVLLTAAKEVQILEKAMQLGVFDFLVKPVLLSRLDQALSRFE-----
+-----TVIIVEDEVEVAHLVAQYLFTNRYKVIGMASDISTARSLLGAIVPDLLLLDVYLPDGNGLNLLAELRSQGSRSEVVLLTAAKEVQILEKAMQLGVFDFLVKPVLLSRLDQALSRFE-----
+-----TVIIVEDEVEVAHLVAQYLFTNRYKVIGMASDISTARSLLGAITPDLLLLDVYLPDGNGLNLLAELRSQGIRSEVVLLTAAKEVQILEKAMQLGVFDFLVKPVLLSRLDQALSRFE-----
+-----TVIIVEDEVEVAHLVAQYLFTNRYKVIGMASDICTARSLLGAITPDLLLLDVYLPDGNGLNLLAELRSQGIRSEVVLLTAAKEVQILEKAMQLGVFDFLVKPVLLSRLDQALSRFE-----
+------TVIINDNANYFKEITSLISNKELNLIANYENPIRCLTELKKRELKVVIMTTNIMGYSGLEVAKQIHHLDKKIKIIFIADNH--DYAVEAFDVGAFDYLLWPVEEKRFRETINRL------
+-----TVIICDDERIIREGLKSSIQDYNFNEVLLAKDGEEALELIHLNHPLLVIIDIRMPKMNGIQLLENIKDI--SCEKIILSSYDDYEYMKAGIQHKVTDYLLKPINQQELKQILNKIYEKY--
+-----TVIIASADSNFRQMVKSAVKNLDYIVVGECADGPTALKMARNFQPDMFIIDDHLIGVPGREIAKILSF-DRQCAVVLAMEFEIDKLDEFLGEMGVVGVVIKPLEEEQLIMTVQ--------
+-----TVHVIDDDMAVRQSLAFLLQTVGIP-VRVYDSAVAFLNALPAVQRGCVVTDIRMPEIHGLELQRRLKPLDLSLPIIVITGHGDVPLAVEAMKAGAVDFIEKPFDDEVVLSAVRSALD----
+-----TVHVIDDDLAMRESIEFLLSSAGYE-VKLYESAQTFLDLPD-VEFGCILSDVRMPGIDGLDLLKRQKAAGSKLPVLIMTGHGDVPLAVEAMKLGASDFIEKPFDDDRLIGLIELALKQA--
+-----TVHVIDDDLAMRESIEFLLGSAGYE-VRLYESAQAFLDEPE-VEFGCILSDVRMPGIDGLDLLKRQKAAGSKLPVLIMTGHGDVPLAVEAMKLGASDFIEKPFDDDRLIGLIELALKQA--
+-----TVHIVDDDKSFRAAVGRMLAASGFQ-IESYSSGEELLARLPR-GSGCILLDLQMPGLSGLELQARLADLAPLLPVVFLTGRGDIGITVRAMKAGAHDFLEKPASSAAVLEAVERALQ----
+-----TVHIVDDDADFRDGLAWLLDSRGLP-TRSWSGGDMFLQSLRPGNCCVVLLDIRMEPLSGLATFEQLKAMGWPWPVLFLTGHGEMSMAVAAVKNGAWDFLEKPFQNNLLVDKVEAA------
+-----TVHIVDDDAALREALDSLFRSVGLE-TRLFANAQAFLESGAAQEAGCLVLDVRLPGLSGLDFQEKLAAADVRMPIVLMTGHGDIPMSVRGMKAGAVDFLTKPFRDQDMLDAVASALQRD--
+---TVHILVIDDDSSLCTSLSYYLERHGYT-VHSASDALQALDVLERHPVGFVITDYLMPHLDGIHFTEIVKARFRSIPVLLITAVVDGSVTDKSLRKGVALTLQKPVDMGQLLNLVR--------
+---TVHIGLVEDDTNIQNIVSAYLKKEGYQ-TTILDNAEDGWKLWENNPPDMWILDIMLPGMDGYEFCKKIRNE-SDVPIIIISAKDEEIDKILGLELGGDDYLTKPFSPRELIARVKRLFKRS--
+------------------------------TVHEAATVAEARARAQAGPCDLAILDLGLPDGSGIELVTELRSH-GWPRVVVLASSDDPYAVRSAFQAGAQAYLLKSASPVVVTDGVRRVLE----
+-----TVGVLDDDPAVLQSLRFLLETHGFK-VRTFSSALTLLTSIDPDNVDCLVIDYKLPDIDGLNVAERLRERNVAVPIVLVTGHPHQHMAKKAAAAGIDHILLKPHLGDNLVTHVQEAISRK--
+-----TVGLADDQQLVRAGFSMVLGQDDIEVVWEANNGREAVMLAQRQPVDVILMDIQMPVVNGIDATKEIVAQGELTRIVVLTTFDTDNYVVQSIEAGASGFLLKDTSPEELISAVQSVGE----
+-----TVFVVEDDADIARLVRYHLEGAGFA-VRTFLTGNGVIPESEKTPPNLFLLDIMVPGADGLEICRQIRHSIAMTPVIFLTAKTSEADKIAGLDLGADDYIAKPFSPRELIARIKAVLRRF--
+-----TVFVVDDSRTAREVVRLHLTRLGCE-AVALEGGEACMAELARRTPALILLDLRMERMQGDEVCRLVKAAGRNVPVIMFTSGGEPHEVMHCWRAGADDFLPKPVALGALEAKLAAVRQ----
+-----TVFVVDDEESVRHSLNWLLSSIALD-VKMYDSAQAFLDADISCSYGCLILDVRMQALSGLQLQEALCARGFSLPIIFLSAYGDAQIGAQAIKKGAIDFLQKPYRNQDLLDAVNAALT----
+-----TVFVVDDEASVRDSLTWLLNSISLD-VRTFESAKDFLDADISCTHGCVVLDVRMQNVSGLQLQQALSERGFKLPIIFLSAYGDAQMGAQAVKKGAFDFLQKPYRNQDLLDAVNAALA----
+-----TVFVVDDDNMVRTALLRLLASAGYA-AHGFASADEFLQARLPAVPCCLLLDMKMPGSDGFEVVRRLERRGDAIPVIFISGYGTIPTTVQAMKAGAHEFLTKPIQDERLLGAVEEALQ----
+-----TVFVVDDDISVRESLELLIGSAGWR-PILFDSAQAFLSATPNAGPSCLVLDVNMPGLNGLDLQSLITKSGNRTPIIFVSGFGDVPMTVKALKGGALDFLTKPIDAEALLAAIQSALSQS--
+-----TVFVVDDDEDLRDSVVTLLRASGYV-VRSFVSGDDFASKYQQTQPGCLLLDIRMPGIGGLELYQQLLLQGRRLPVIFMTAHASVEIAVTAMKSGAIEFLEKPFESQRLLKLVAQALE----
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFSSAEQFLEAYQAGQIACLILDVRMSGMSGLELQERLIAENAALPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRKLVERMLDKA--
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFSSAEQFLDAYQAGQIACLILDVRMSGMSGLELQERLIAENAALPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRKLVERMLEKA--
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFSSAEQFLDAYQAGQIACLILDVRMSGMSGLELQERLIAENAALPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRKLVERMLDKA--
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFSSAEQFLDAYQAGQIACLILDVRMSGMSGLELQERLIADNAALPIIFVTGHGDVPMAVSTMKKGAMDFIEKTFDEAELRKLVERMLDKA--
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFSSAEQFLDAYQAGQIACLILDVRMSGMSGLELQERLIADNAALPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRSLVERMLNKA--
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFSSAEQFLDAYQAGQIACLILDVRMSGMSGLELQERLIADNAALPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRKLVERMLDKA--
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFSSAEQFLDALQAGQIACLILDVRMSGMSGLELQERLIADNAALPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRKLVERMLDKA--
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFSSAEQFIDAWQPHQIACLILDVRMSGMSGLELQERLIADNTLLPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRKLVERMLDKA--
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFSSAEQFIDAWQPHQIACLILDVRMSGMSGLELQERLIADNASLPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRKLVERMLDKA--
+-----TVFVVDDDEAVRDSLRWLLEANGYR-VQCFLSAEQFLDAWQPHQIACLILDVRMSGMSGLELQERLIADNASLPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRKLVERMLDKA--
+-----TVFVVDDDEAMRDSLTWLLEGNGYT-VRTYRSAEEFLVDDKREGVGCLILDVRMQGMSGPELQDRLLAENSRMPIVFVTGHGDVPMAVSTMKKGAVDFIEKPFDESELRELVERMLSKA--
+-----TVFVVDDDEAMRDSLTWLLEGNGYT-VRTYRSAEEFLVDDKREGVGCLILDVRMQGMSGPELQDRLLAENNRMPIVFVTGHGDVPLAVSTMKKGAVDFIEKPFDESELRELVERMLSKA--
+-----TVFVVDDDEAMRDSLTWLLEGNGYN-VRTYRSAEEFLVDDKREGVGCLILDVRMQGMSGPELQDRLLAENNRMPIVFVTGHGDVPMAVSTMKKGAVDFIEKPFDESELRELVERMLSKA--
+-----TVFVVDDDEAMRDSLTWLLEGNGYN-VRTYRSAEEFLDDKRSEGVGCLILDVRMQGMSGPELQDRLLAENNRMPIVFVTGHGDVPMAVSTMKKGAVDFIEKPFDESELRELVERMLSKA--
+-----TVFVVDDDEAMRDSLTWLLEGNGYN-VRTYRSAEEFLDDKRNEGVGCLILDVRMQGMSGPELQDRLLAENNRMPIVFVTGHGDVPMAVSTMKKGAVDFIEKPFDESELRELVERMLSKA--
+-----TVFVVDDDAAVRDSVSALLESASFR-VENFDSAASFLASRATERPGCLVVDIRMPDMDGLELQEEMVRRQIALPVIVMTGHADVPLAVRAMKAGAVDFIEKPFNDELLLDSVARALE----
+-----TVFVLEDDLDISRLVQHHLEGAGFQ-VRSYLTFGSIVEDAEKSRPALFLLDVMVPGGDGMELCRRLQRLLSGVPIIFLTARATESDRVLGLDLGADDYITKPFGTRELVARVKAVLRRF--
+-----TVFVLEDDADISRLVQYQLERAGFI-AKPYAAIGSIVQDAERSRPALFLLDIMVPGGDGMDLCRRLRQHLSGVPVIFLTARASENDRVHGLELGADDYITKPFGTRELVARVRAVLRRF--
+-----TVFVIDDDELDILMYERVFQRSAVERAVNFSFAQSALEVLDSERPELIFLDINMPGMSGFDFLRAIEDDLEMFPTVIMSTSDLAEDREQARSFNVIAYFTKPVSMIRLLTCCTRASR----
+---------------------TVFSLDGHQ-PLCAADGQHALELFKQQAPDIVLMDIRMPKVSGLEALQVMRQIRQETPVILMTAYAAVETAVEALRLGAFDYVIKPFDLDELKIIISRAMQ----
+-----TVFLVEDEAMIRMMVVDMLEELGFSVAAETGEINEAVKLAGTTDFDVAILDVNVNGKVISPVADVLKAR--NRPFIFATGYGTQGVPEDYRDRPA---LQKPFQIESLKQALDTTLR----
+-----TVFLVEDEAMIRMMVADMLEELGYHVAAEAGEINEAIRLAGTTDFDIAILDVNVNGKVISPVADLIKAR--NRPFIFATGYGTQGVPEDYRDRPA---LQKPFQIETLAEVIASTLK----
+-----TVFLVDDHEVVRRGLVELLEDPDLSVIGEAGNCSHALARVPALRPDVAVIDVRLPDGSGIDLCRELLAKVPGLRCLILTSFTEDQAMLDAIMAGASGFVIKDITGMELAKAVREVG-----
+-----TVFLVDDHEIVRRGLADLLTSDGHRVVGEAATVREALARIPAVAPQVAVVDVRLPDGSGIDLIRTLRDQHPRLPCLVLTSYSDDEALLDAITAGAQGYVLKQIRGTELVSAIATVA-----
+-----TVFLVDDDQGMRDSLTLILELAGYP-VRSFPTPAAFLAAFSPDERGCLVLDQRMPDMTGLDLQSELLERGALLPIIFLSAFGDVPTTVRAIQGGAIDFLEKPASTEQLLQRIEDAFAE---
+-----TVFIVEDDPSVRDALGLLLGLHGLT-VALFADAESFLAARRPDWYGCLLIDIRMPGMNGLALQKHLLESGCWLPVIVMTGHGDVDSARQAFRAQAVDFVEKPIDHDRLMRAIEEAFARQ--
+-----TVFIVDDHPLLLRGLADLIADSGYRVIGTALDGRSALTMIRQDLPDVAVIDLNMPGFSGLDLAFELGKETPTTRCVMLTAGASQSQLYEVIKAGVAGIVLKEAAIGTLLRCIHRVA-----
+-----TVFIVDDDEAVRDSLRWLLEANGYR-VRAYASGESFLEDYDASQIGVLIADVRMPGMSGLELQEQLLARNAPLPIVFITGHGDVPMAVSTMKKGAVDFLEKPFNESDLREIVARMLEQA--
+-----TVFIVDDDEAVRDSLRWLLEANGYR-VRAYASGESFLEDYDASQIGVLIADVRMPGMSGLELQEQLIARNAPLPIVFITGHGDVPMAVSTMKKGAVDFLEKPFNESDLREIVARMLEQA--
+-----TVFIVDDDEAVRDSLRWLLEANGYR-VRAYASGENFLDEYDASQIGVLIADVRMPGMSGLELQEQLIARNAPLPIVFITGHGDVPMAVSTMKKGAVDFLEKPFNESDLREIVARMLEQA--
+-----TVFIVDDDEAVRDSLQWLIETEGYQ-VKTYEDPELFLEQLVWPQPCVLLLDIRMPKLSGLEVQKTLNERGIPIPIVFITGHGDVTLAVETMKNGAVDFLEKPFDEGKIKDLIHQHMRHA--
+-----TVFIVDDDEAMRDSLTWLLEGNGYQ-VRSFTSAEQFLAAYDASQVSCLILDVRMPGMSGPELQERMLAEQIDIPIVFITGHGDVPMAVSTMKRGAIDFIEKPFDESELRALVERMLTKA--
+-----TVFIVDDDEAMRDSLTWLLEGNGYQ-VRSFTSAEQFLAAYDASQVSCLILDVRMPGMSGPELQERMLAEQIDIPIVFITGHGDVPMAVSTMKRGAIDFIEKPFDESELRALVERMLQKA--
+-----TVFIVDDDEAMRDSLTWLLEGNGYQ-VRSFNSAEQFLSAYDASQVSCLILDVRMPGMSGPELQERMIAENIDIPIVFITGHGDVPMAVSTMKRGAIDFIEKPFDESELRSLVERMLQKA--
+-----TVFIVDDDEAMRDSLTWLLEGNGYQ-VRAFSSAEQFLAAYDAGQVSCVILDVRMPGMSGPELQERMIAENIDIPIVFITGHGDVPMAVSTMKRGAIDFIEKPFDESELRSLVERMLQKA--
+-----TVFIVDDDASIRRSLERLIKSVGFQ-VESFASAQEFLRREPTIRPAGLVLDVRMPGPSGFDLQDKLAFLHCNLPIIFITGHGTIPLSVRAMKGGAIEFLTKPLDEQYLLDAIHKAVE----
+-----TVFIVDDDASIRDSLSLLLSLRGYA-TALFANAEDFLAALQPDWRGCVVVDIRMPGMSGLELQRCLRERGPSLPVIVITAHGDVAAARQAFLADAVDFIEKPFDGKQLLGAIENALS----
+-----TVFIVDDDASIRDSLSLLLSLRGFA-TALFANAEDFLAALQPDWRGCVVVDIRMPGMSGLELQRCLRERGPSLPVIVITAHGDVAAARQAFLADAVDFIEKPFDGKQLLGAIENALS----
+-----TVFIVDDDAGMRESIHDLVESVSLH-AESFSTAQGFLSGERRDGPSCLVLDVRLPDTSGLDLQQELSRAGIKIPIIFITGYADIPMTVKAMKLGAVEFLTKPFREQDLLDVIHRALRRD--
+-----TVFIIDDHPVIRLAIRMLLEHEGYKVVGETDNGCDAIQMVRESLPDLIILDISIPKLDGLEVLCRFNAMNTTMKTLVLTAQSPTLFATRCMRSGADGYVCKEGDLSELLSAIRAVLS----
+-----TVFIADSHPVVQVGITQMLSETGFKVIGTARTSSELFEKLENETPDILMLEMDFPEINGIACLRKMKKNHPDVKVLMYSGQSEDVYAISSIRAGAQGYLSKNADLDYIVAALEKIS-----
+-----TVFIADDDEIFLAGTIDLFQRMGYA-IDSARSVNEALAKLDTHQWSLAVVDLLMPMANGLKVIQQIKQKMPWLGIIVVTSYR---------------------------------------
+-----TVFAIDDSPLNLKILQRFLEKQGWK-VFIAEDGLTAITEINQVQPDIIVLDIMMPGIDGFEVCRRLKAATAEIPIIFLSALTDQKSIVKGLELGAVDYIHKPFQQEEIITRLQL-------
+---------------------------TVE-IVTAMNAQEAASALAAGPCHCVVLSLDLPDGEGPRLLEAVDGALATVPLLVHNNHRPSAAQEAALQARAENSLEVLSSLDELKERI---------
+--------TVDDQPEVRSALRLMLGEPDIAVVGEPVDGDHARDVIEACRPDVVLMDLRMPRCDGLVATARETALRPETAIIVLTTFDTDHHVVRALRAGACGFLLKDAPPDELAHAVRAAAQ----
+-----TVCVVDDDKIYVYGLKKLMSLKQLSNLIEFPNGKEAIDFLINPDPDVIFLDINMPVMDGWDFMENYARLGKKITVYMVSSSINQEDINRAKNSHITDYVVKPVTYDKLLELFKEA------
+-----TVCIIDDDPIFVYGTKVILNSNGCSNIMVFEDGEEALDDLNQTLPEVIFLDLNMPIMDGWDFLDEFCKIENKTRIYILSSSIFSVDIEKSKEYKVKDFISKPLTDSKFEILLKD-------
+-----TVAVVDDDAAARISLVRLLQLEGYH-VHEYDSASSFLEGAENRAYSCIVTDLRMPGVTGLDLQKSLEGRGVFVPLVFVTAFGTVPASVQAMRSGAVDFLEKPADPSALLDAVKRAVARC--
+-----TVAVIDDNPDHRALVRDILDPLGFV-VLEAASANQCVEVVLPLKPDLYLVDILMPGTNGWELIKDLRMKGEMAPIIMLSANIGDQALKPEGPANHTASLAKPFDIHQLLDLIQQH------
+-----TVALVDDHDVIALGVTTMLATASLHFRGGYPSVAQLLEETAATKPDVVLLDLRLPNSDPSHNARTLRTR--GAAVIAYTSGDDPYLIRRACEGGVLGVVRKSETPDVLISTIWAALR----
+-----TVALVDDDRNILASVSIALEAEGFD-VRTYTDGAEALRGLSQRPPDLAVLDIKMPRMDGMELLQRLRQT-SQMPVIFLTSKDDELDELMGLRMGADDYIKKPFSQRLLIERIRALLRREA-
+-----TVALVDDDALVRAGLSLILGDPELRIVGEAADGVAAIELVRRERPDVVLMDIRMPRLDGLAATQRLVAAGTRSRIIVLTTFDADAMVLEALQAGAAGFLLKDTPPERLVAAVHAAA-----
+-----TVALIEDDADFRQALVERLTLEGLE-VRAFTAAEPALKALDADFPGVVVTDLRMPGMDGRQLLTRLQALDTSLPVIMITGHGDIADAVAAMHDGAYDFVAKPFPFERLQDSLNRALEKRS-
+-----TVALIDDHDVIALGVTTMLASLHFR--GGYPSVAQLLEETAATKPDVVLLDLRLPNSDPSHNARTLRTR--GAAVIAYTSGDDPYLIRRACEGGVLGVVRKSETPDVLISTIWAALR----
+-----TVAIVEDNRDFRATLARYVDEAGHRCICECGTSEEALQKLPRLMPDVVLMDIHLPQMSGLDCTRRLKEICPSIQILILTVYEDNERIFGALKAGAGGYLLKRADPADILSAIQDV------
+-----TVAIVDSDREFATNLATQMGYFDLQ-AHTYTSTTAFLADLNETLPGILVISAQLSKGNGIAVASEAASRLAERPRILISSDDDMKLRLACVRAGGEAFLVKPFEATQVIALINK-------
+-----TVAIVDDDGGVRTSLTSLVRSLGYQ-VRAYTSAREFLDDKQSPEPDCMIADIQMPHMTGDRLQAVLSSSGRSFPIIFMTAFPSEAVRDRVMAAGARDYLEKPPDSDVIARRLADLL-----
+-----TVAILDDDPLSCEALSSLLRADGYC-ALTFGSVNDLLRSGP-ERFGCIFSDIWMEGQTGIDLLEILAGQGNMPVVILMTARFDRDQAAHAMEIGARAVLEKPLSAERVSELV---------
+-----TVAIIEDQTAIREMMSQILDRDEFEVVLECGDGQIGLERTLELKPDFVILDVMLPNLNGTEILRRLAKELPDARVLIFSGYQTPGLVRELLQAGAHGFVEKAAPLTELRKGIE--------
+-----TVAIADDQAMQRFGFRMLLESQDMALVGEAETGSAAVRLCAELQPDVVLMDIRMPGLDGIEATRRIVASGGRTRVLILTTFDLDEYAHAGLRAGASGFLVKDARPEELLAGIRAVA-----
+---TTYVLLVDDNPNNLKVLSEAIQRCGWK-ALMATDGESAIRQTEYAHPDLILLDVMMPGLDGFETCRRLKALTYNTPVIFMTALCDPTDKVKGLEIGAVDYITKPFQHEEVIARLKLHL-----
+--TTYTVLFVDDEPNILRAIKRALFTMDIT-LLLADSGAKALELMSANEVHVVISDMKMPQMSGAELLEQVAINYPETFRVVLTGYADIESTIKAVNQGIHRYLQKPWDNQELISVVEEGLERV--
+--TTYTVLFVDDEPNILRAIKRALFTMDIT-LLLADSGAKALDLMSKHDVHVVISDMKMPQMSGAELLEQVAINYPETFRVVLTGYADIESTIKAVNQGIHRYLQKPWDNQELIAVVEEGLERV--
+--TTYTVLAVDDEPSIGKLLEKELSTPTRT-VHVATSARQARERLRRATYEVVVLDIRLPDADGIEFMVELRQRYPDTEVILITGHGNIDNAVEAMKLGAYDYITKPFNLTELEVVVERAYQRA--
+--TTYTVACIDDSPTVLNAIQKFLEDQSLS-VVAINDPVKALMQIVRSKPDLVLLDITMPNLDGYDLCALLRRRYKHTPIVMVTGNTGLIDRARAKLVRASGYLTKPFTQDDLLKMVFKH------
+--TTYTIACIDDSTTVLNAINSFLDDKSFS-VVMINDPVRALMQVVRIKPDLILLDVEMPNLDGYELCSLLRKHFKTTPIIMVTGHTGFLDRAKAKLVRASGYLTKPFNQSELLKMVFKH------
+--TTYRVLVAEDDPINGKIVQKRLGKIGHA-VRLTVNGEECAAAYRADPYDVVLMDIQMPLVDGMSSTRMIRELNGRVPIFAVSASLLEKDASLYMDTGFDGWIMKPINFSRLNTVLDGL------
+----TTVVLVDDHQMFRSGVKAELGD-GVEVVGEAGDVDEAIAVITATEPDVVLLDVHLPGGGGIEVLRRLHGK-VRSRFLALSVSDAAEDVIGVVRGGARGYVTKTISGPELTDAIGRVAE----
+----TTVVLIEDEKQIRRFVRAALEGEGMV-VHDAETGKQGLVEAATRKPDLVIVDLGLPDTDGLDVIRELRG-WSELPVIVLSARTQESEKVAALDAGADDYLTKPFGVSELLARIRAHLRRR--
+----TTVVIADDHSIIRDAIYDLLSVANFEIVGTAENGLEAIAAIKAKRPGLLFLDVSMPLAGGAEIIHDVRRWSPDTRIVIFTGVTSPSVLAGILEAGADAIFSKLSPARDML------------
+----TTVVFVDDNDNYLDALRRFFPDVSTN--LFFSRPQTALAFIRE--FAAVVVDYDMPGVSGVEFLSSISNL--HCAKILLTGVADETVAVKAFNAGIVDLYLRKTDADS--------------
+----TTVVFVDDNDNYLDALRRFFPDVSTN--LFFSRPQTALAFIRA--PAAVVVDYDMPGVSGVEFLSSISNL--HCAKILLTGVADETVAVKAFNAGIVDLYLRKTDADS--------------
+----TTVVFVDDNDNYLDALRRFFPDVSTN--LFFSRPQTALAFIRA--PAAVVVDYDMPGISGVEFLSSISNL--HCAKILLTGVADETVAVKAFNAGIVDLYLRKTDADS--------------
+--TTVRVVLVDDETLVRVGLRLILGDPAIEVVGEAADGVEALDVIAATSPDVVLMDIRMPRLDGLGATERLLAAQPDARVVILTTFDTDEMVLGALRLGAAGFLLKDTPPAEIVRHV---------
+--TTVRVLLADDEHLIRGALAALLSEDDLVVVAEAATGPEALAMARAHAPDVAVLDLQMPGADGVKVATSLRAELPACKVLIVTSHGRPGHLKRALAAGVRGFVPKTVSAQRLAELIRTVH-----
+--TTVRIFLVDDHEVVRRGVADLLEEPGLEVVGEAGTCAEALTRVPALRPDVVVLDVRLPDGDGVSVCRELRSR-LDVACLMLTSFDDDEALFDAILAGAAGYVLKQVRGTDLVAAIRTVA-----
+----TTVMVVDDSVTVRKVTSRLLERNGME-VITAKDGVDAIALLQDHKPDVMLLDIEMPRMDGFEVASLVRHRLKDVPIIMITSRTGQKHRERALSIGVNEYLGKPFQEKILLETIERLV-----
+----TTVMIVDDSLFMRKMLRDILTEEGYEITAEASDGNEAIEKYQECRPDLVTLDIVMPNKTGIEALQIIMVLDPQARVVMCSAIGQESMTEAAAKAGAKAFILKPFNPELVARTLREVAE----
+----TTVMIVDDSLFMRKMLRDILTEEGYEIIAEASDGDEAVAKYRECRPDLVTLDIVMPNKTGIEALQIIMALNPQARVVMCSAIGQESMTEAAAKAGAKAFILKPFNPELVARTLREAA-----
+----TTVLVVEPDLDTQRVYRQRLHDPDIKLIGICSSIASATALLAQTNCDILFTELNLPDGDGLDFIRRASEDLAVQSIVAVTSKNSAADIATAIENGAVGYITKQ-------------------
+----TTVLVVEDTLSEQELISLYLRKAGYT-VITANDGKEAIEKTLAQKPDVIVTDVVMPNMNGFELCRSIKKQTQKLPVIACTSKTQDLDRLWGMKQGIDVYVTKPFTPEELIRAVKSV------
+----TTVLVVEDEPAIAQAVAHRFSAEGWR-VEVAADGPSGVSAATRVQPDLVVLDVMLPGIDGLEVCRQIQAE-RPVPVLMLTARDDETDMLVGLGVGADDYMTKPFSMRELVARTKALLRRQ--
+----TTVLVVEDEPAIAQAIVHRLTAEGWT-VEAVGDGHAGVAAAARLQPDVVVLDVMLPGIDGLEVCRQIQAE-RPVPVLMLTARDDETDMLVGLGVGADDYMTKPFSMRELVARTKVLLRRT--
+----TTVLVVDDMEASRYAMGSVLSRAGHR-VVPVATGREALAELETRLPDVALVDVGLPDMSGFDLCRLFKEHTAGMPVVHFSAAASPADFCQGLDGGVEAYLKVPAEPLEIEAVVRAAVRNA--
+----TTVLVVDDEADVRDVTARLLTHLGFR-VVVVADGASALQALQEQEIACVLLDANLAGMDAPTTLRELRALAPHIPVVVSSGYSQHEVLQRFAGQTIEGFIQKPYQMSELYGVLQHALRQ---
+----TTVLVVDDDPQILRALRINLAAHGYA-VLLAEDGAAALRRAADGHPDVVVLDLGLPDLHGSEVIEGIRG-WSAVPIIVLSARGDSGDKVRALDAGADDYVTKPFGMAELLARLRAAVRRAA-
+----TTVLVADDHPLWLGALERDLAQAGLDVVATAADGPSTVRRTRATRPDVLVLDLNLPGMRGDEVCRALGDL--ETRVLILSASGEQLDVLAAIKAGATGYLVKSASSEDIVAAVLATAR----
+----TTVLLVDDQPLLRMGFRMVLDQPDLRVVGEAGDGGTAVRLTAELAPDVVLMDVRMPGVDGIEATRRIVASGGASKVLILTTFDLDRYAFAGLRAGASGFLLKDVPPDDLLAGIRTVA-----
+----TTVLLVDDHELVRAGFRRLLEDDKFTVIAEAGSGEQAVQDFNKHHPDVVVMDISMPGIGGVGAIERIIAREPSAKILVLSVHEDSVFTTRAMQAGALGFIPKRSAPEEMLRAVEMVAQ----
+----TTVLLVDDEPNILQALQRLLRRETFR-IVTAASGTEALQLLSQRGVAVILSDMRMPAMNGAEFLKRSREFAPESVRMLLTGYSDISDAVDAVNQGISRYLSKPWNDTDLLQAVRIAVES---
+----TTVLIVEDNDGLRRMIVEVLRASGFQQLIQARDAEEAIELLGAYNPELMILDWNMPGLSGIDLTLLLRQANPRIPVLMLTGRQRSRDVTEARNAGVDEFVIKPFSTRSLMRGVASALSRQ--
+----TTVLIVEDDPMNFRVFSKILTKRGFT-VKGSEDVAEVLALARSKAVDVILIDVSLSRYNGIQITQLLKQATASLPVILVTAHAMVGDRESLLQSGAEGYIAKPVDHQAFVNQIQTM------
+----TTVLIVDDHDLIRKGLRHAFSDPQFEVVAEAGSAGDGLRKAAALQPNVVIMDLRLPDGSGLEATRKLRKAHPSMGIVVLTMYAGDDQLFGALEAGASAFVPKSAPSDDVVSAARHAA-----
+----TTVLIVDDEQDMRNLIEMMLNNSDIE-TYTAASGTEAYDIIVREKIDLVLLDVMMPHEDGFVVCQSIRAM-SNVPIIFLTARDANEDKVKGLTLGGDDYIVKPFTHDELAARIYAVLRRSG-
+----TTVLIVDDDPVQRRLAEAMVRRLGFE-AIVAEGGEAALACLRAAGIDVVLLDLVMPGLDGLGVLAEMRRSAIDTPVIVQTANGSIDAVVTAMRAGAIDFVVKPAGAERLQVSIKNALQ----
+----TTVLIVDDDPVQRRLAEAMVRRLGFE-AAVAEGGEAALAVLRATRVDVVLLDLVMPGLDGLGVLAEMRKAGLDVPVIVQTANGSIDAVVTAMRAGATDFVVKPAGAERLQVSIKNALQ----
+----TTVLIVDDAAFMRMMIKDILSKNGFDVVGEAGDGQQAVDMYKEQSPDLVTMDITMPEMDGITALKEIKTHDPNAKVIMCSAMGQQAMVIDAIQAGAKDFIVKPFQADRVLEAISKTL-----
+----TTVLIIDDDPVQRRLAEAMVRRLGFQ-AQIAENGHDGLNLLRSESVDVVLLDLVMPGMDGLSVLAEMRKSGIDTPVIVQTSNGSIDAVVNAMRAGAVDFVVKPAGAERLQVSIKNALR----
+----TTVLIIDDDPVQRRLAEAMVRRLGFE-PRIAENGHDGLNLLRGGNVDVVLLDLVMPGMDGLSVLSEMRKSGIDTPVIVQTSNGSIDAVVNAMRAGAVDFVVKPAGAERLQVSIKNALR----
+----TTVLIADDQAMVRQGFGALLAQPDISVVGDAPDGKVAVAEAKRLRPDVVLMDVRMPEMNGLDAARAILAADPPVRVLMLTTFDIDDYVYEALSIGASGFLLKDAPAEELVRAVRVVAE----
+----TTVLIADDDPLSRKLLQLHLAPFRFE-VMAASNGQAALELARRRRPKLIIADVLMPGLDGFRLCLALRKRLANVPVLLTVGAPDELDLRMAQNVGANGFVRRTQEGEELIAALLR-------
+--------------------TTVFSLDGHQ-PICAADGQQALELFKQQTPDIVLMDIRMPKISGLEALQIMRQTHQETPVILMTAYAAVETAVEALRLGAFDYVIKPFDLDELKIIIGRAMQ----
+---TTTVLLVDDDPETLAAWAICCAQQGYG-VQSATDGGHALALLDATQIDIVVADWRMPKMSGSALCQAIRNALADTLFILVSGESSPPAFV-----RYDAFLRKPLDYPELFATMRRLLD----
+--TTTRILLADDQDDIRSGFRLILDQPDMTVVGEAADGLRAIEQARLLRPDVLLADVRMPGADGLEVTRVLAG--GPTRVIVVTTFDDDAYVRAALGSGACGFLLKRSGPNLLIEAVRAAMA----
+--TTTNILIVEDEKEIRRFVRIALESEGWR-VFESDTLQRGLIEAGTRKPDLIILDLGLPDGDGLTYIQDLRQ-WSAIPIIVLSARNSEEDKVAALDAGADDYLSKPFGISELLARVRVALRRHS-
+--TTTHVLLVDDNKINLQLLVMFMKKCKFT-YEEAENGQEALDKFTQKRFDYILMDISMPVMNGIEATKRIRQQIQPTTVLALTGLASADARRDVLSAGVDVFLPKPVRFAELKKLLT--------
+---TTSVLLVDDDPMVRNGLRMVLRDPGIVVVGEAGNGRQAVDQARELRPDVVLMDLQMPVMDGVAATRELRGLPDAPAVLVLTTFHLDTYILDALGAGASGYLLKDIPPTEIARAVQMAA-----
+---TTSVLIVEDDPAALSRLVQAVEMHPATVAGCTASAAEALAWLAQHQPDVLLCDLGLPDGSGIDVIRAARERYPACDCMVVTVFGDDHHVLASIEAGAIGYLLKDETTDRIAASIG--------
+--TTSTILVVDDEENILRAIVRLLMENDIN-VLTAGSGSEGLSVLQAHPVALILSDQRMPGMTGAEFLQQAKSLAPEAIRMVLTGYADINATMDAINKGASCYITKPWDDGMLVQTLTEGVQRY--
+---TTSILLVDDQPENLTALRAILADESYR-LVTAASGKDALLRILSEDFAVILLDVRLPDIDGFEVASLVKQRSRHTPIIFLTGATDDAAIYRAYAVGGVDYLLKPLEPEVVQAKVAVFV-----
+---TTSILLMEDEIIIAMDVEDILHGAGFDRIETVSSCRAAEEWLTANDPDLVVMDIELTDGVAGAIARSLRGR--HIPFIVYTGAQR-KVHPDALSFSEGVWLEKPCEPSILLTEVMRCI-----
+---TTSILIADDDXXXXDLVKLYLQNEGYT-IYQAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVCRLMRDNGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQ-
+---TTSILIADDDKEIVDLVKLYLQNEGYT-IYQAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVCRLMRDNGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQ-
+---TTSILIADDDKEIVDLVKLYLQNEGYT-IYQAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVC----------------------------------------------------------
+---TTSIIVAEDNSVNRKVILKMLESLGHK-ADAVCDGEELVQQFDPQRHKIVLTDLNMPNLNGIKAAQELRKRGNDFKIYLLTGNVM--ACEEDYSSIIDKVVIKPVSKTNLKHLI---------
+--------------------------------TTSEDGKNGFELALSNQYDFIILDVMLPGMDGLEITKALRREKIDTPILILTAKDEQVDKIIGLEIGADDYLTKPFSPREVLARMKAIFRRL--
+---TTRVVIAEDEALIRLDLREMLEEEGYSVVGEAGDGERAVELAREHRPDLVILDVKMPKLDGISAAERIAEE-RIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+---TTRVVIAEDEALIRLDLKEMLEEEGYTVVGEAGDGEQAVELAREHRPDLVILDVKMPKLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKTDVVPAIEMAVSRF--
+---TTRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGETAVALAREHRPDLVILDVKMPILDGISAAERIAAD-RIAPVLMLTAFSQRELVDRARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+---TTRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGETAVALAQEHRPDLVILDVKMPVLDGISAAERIAAD-RIAPVLMLTAFSQRELVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+---TTRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGEQAVELAREHRPDLVILDVKMPKLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+---TTRVLLVEDEEVARKTLSFYLNTIFDE-VVVASDGQEGINFYKERCFDLVLTDIKMPNKDGIEMIDEILEIVPDQKFIIVSAHKNEEDLLKLINLKVLGYFVKPLNVDDMMDMLQKA------
+--TTRSILLADDSPTVLRTMQLILNKLGVV-HHDFINGKHLLDYLFANSIGMIITDLEMPEASGFEVIKQVKAATAHLPIVVNSSMSGSSNEDMARSLNADEFISKS-NPVEIEAAVRRF------
+---TTRLILVDDHPLVRDGLRARLEARNLEVVGEAGNAQEALALAASHEPHLVLMDVGMNGMNGIALAGMFHERFPAIRVLMLSMHDNLQYVTQAVRAGASGYVLKDSPATEIIQAISAVLEG---
+---TTRILVVDDEEDLCEILKFNLEIEGYE-VDTAYSAEEALKK-DLTVYNLLLLDVMMREISGFKMARILRQKTANTPIIFLTAKDTENDMLTGFNLGADDYISKPFSIRQVIARVKAVLRRT--
+---TTRILVVDDEEDLCEILKFNLEIEGYE-VDTAYSAEEALKK-DLTVYNLLLLDVMMGEISGFKMARILRQKTANTPIIFLTAKDTENDMLTGFNLGADDYISKPFSIRQVIARVKAVLRRT--
+---TTRILLVEDDEDDYVIARDVLEEISFLELIRAANVSAAYDYLKQNNFDLCLLDYQLGAFNGIEVLKHARASGFSAPIIMLTGQADSKLDEQALDAGAADYLNKEIGTGRFIRSIRYALARR--
+---TTRILLVDDHPMMRRGLRDLLDEDDLEMVGEAGNGEDAIRLALQIEPDLILMDLNMPGIDGLETTRRMRDADIDARIIMFTVSDEQSHVLEALRNGADGYLLKDMDAEQLIEQIRI-------
+---TTRILLADDHALVRRGVRLILEEPDFEVVAEAGDGAEAVQAARTHRPDLAILDVAMPRMTGLQAARELSQLQPDLRILMLSMYDNEQYFFQALKAGACGYVLKSVADRDLVEACRAAVR----
+---TTRILIVDDDVEIRNLLGGYLSRFGME-AVGVHDGAAMKKALTESSFDLVVLDLMLPGEDGLTLCRSLRGE-SDIPVIMLTARGDPMDRVVGLELGADDYVAKPFEPRELVARIQSILRRA--
+---TTRILILDDDPFILKLLARMLINLGFPSVDCCENGVDALKLLDDTRPDLILLDLNMPGMDGIEFVRYLVERKFTGSLILVSGEDEREKLVQAHKIPILGYLQKPVQPEALRMQLMKLAS----
+---TTRIILADDHTVLRTGLRLLIDQPDFTVVGEAADGEALLALVERVPAEVLVLDLSMPRVSGLECIKELKSRGQEIKILVLTMHGR-EYVKEAMAAGALGYIEKQALDSELFVAIRTVA-----
+---TTRAVIVDDSRFMRTLIRTLLEDGGIDVVAEASDGAAAVETVTEHAPDVVTMDIEMPEMNGIEAVEAIMED-CPTPVLMLSAHAEDDVTFEALDKGAVDFVTKP-------------------
+---TTRALIVDDDVAIRELLCDYLTRFNIQ-ARGVTDGAQMRLALDEEKFDVVVLDLMLPGEDGLSLCRWLRST-SDIPILMLTARCEPTDRIIGLELGADDYMAKPFEPRELVARIQTILRRV--
+---TTRALIVDDDVAIRELLCDYLKRFNIQ-ARGVTDGAQMRLALDEEKFDVVVLDLMLPGEDGLSLCRWLRST-SDIPILMLTARCEPTDRIIGLELGADDYMAKPFEPRELVARIQTILRRV--
+---TTQVALVEDDTGVRERIARVIGDPSLALAYSASNAVDMLRWLGENPVEVLLVDLGLPDLPGLQVIRRCRSMQPACAVMVLSIFGDEANMVLAFEAGASGYLLKDGTEADLATHIRNL------
+--TTQRILIADDEPLFRETTAEFLREEGYE-CLCVEDANDAISVLEEHKFDLILSDLNMPGNLKFELLKEGRTKHSDVPMIVVTGAPSLPSAIESVRLGVTDYLLKPVKLEELLTAVQRSLSQA--
+--TTQRILIADDEPLFRETTAEFLREEGYE-CLCVEDANDAISILEEHKFDLILSDLNMPGNLKFELLKEGRTKHSDVPMIVVTGAPSLPSAIESVRLGVTDYLLKPVKLEELLTAVQRSLSQA--
+---TTQILIVDDDQELRDLLRDYLVRQGME-VSVLHDAATLEKRLERERPDLIVLDLMMPGVDGLTALRQLRAAGDDIPVIMLTARADDVDRIVGLELGADDYLGKPFNPRELLARVQAVLRRR--
+---TTQILIVDDDQELRDLLRDYLVRQGIE-VSVLHDAASLEKRLERERPDLIVLDLMMPGVDGLTALRQLRAAGDDIPVIMLTARADDVDRIVGLELGADDYLGKPFNPRELLARAQAVLRRR--
+---TTQILIIEDEPLIAMDIEQMVESLGHKVVGVARTSEEAMAMFQQKRPRMILADIQLASSSGIDTVNDILKN-ECIPVIFITAFP--ERLLTGERPEPTFLVSKPFNPDMVKALISQAL-----
+--TTPTVLVIDDVAEIVEELLTLLSLREIS-ATGAHSLDGAIGALENAQIRVIACDVRLGKESGFDICDRIRTKARNFAYIFISGD--PMRLNQASHLPKHSILTKPVEPRALIELLREKLDA---
+--TTPTVFIVDDDPAVLDSLAMLITAQGMK-TVTFPNAMEFLDGYQGNQICCLVLDIRMPQITGLALQEQLMERNISIPIVFITGHGDIEQCRRAFQTGAIDFLTKPIDQNRLIASLRRGI-----
+--TTPKVLLIDERKTSVERIQKMLRDRA-D-LDVTHDPHAGFFQAAETSYECVMISTAFADFDPLRLCSQLRSRTRFVPIILLAEEGEEERIIRGLELGINDYLMRPIDQQELTARLRTQVRRK--
+--TTPKVLLIDERKSSVERIQKMLRDRA-D-LDVIGDPHAGFFQAAETSYECVMISTAFADFDPLRLCSQLRSRTRFVPIILLAEEGEEERIIRGLELGINDYLMRPIDQQELTARLRTQVRRK--
+--TTPCILIVDDEPLNIRLLDIVLKKNGYR-TLSCTSGPEARALAAEHSPDLILLDVLMPDEDGYATCALLKQQTSDIPIIFISALTDTSSKVRGLEVGGVDFISKPFEKAEVLARVKVHL-----
+---TTNILLVEDDRVDVMNVQRSFKQANIAPLYVASNGVDALAILKGEHRRLVLLDLNMPKMSGLELLQNIRKSLRSTPVIVLTTSNQEKDRMEAYDLNVAGYLLKPVTFGSFFELITTLN-----
+--TTMRVLLADDASVNGTILREQLDVLGCA-VHVVGLAGAALDLLYRSDWDLLLIGTDLPDMAACALAEAVHARGMPCSVAIVTTHLAPDDARRCAAANVQSVLTKPVTLVRLRSVLAAVARRRG-
+--TTMRVLLADDASVNGTILREQLDALGCA-VHVVGLAGAALDLLYRSDWDLLLIGTDLPDMAACALAEAVHARGMPCSVAIVTTHLAPDEARRCAAANVYSILTKPVTLGRLRGVLSGVARRRG-
+--TTMNTVLIEAHPLVRTGIAHLLRTLGVTGVTVVEPDEGMFDAIETNDAGLLVIGLPLPHLDELSAIGEIMHRPHARHVVVLAESESPDIIRTLMQMGLSGYTLKHSPGEVIAASL---------
+--TTMKVLVAEDELVTRLMVQVSLENWGYD-VLEAKDGKEAMELFGREAPRIAIIDWEMPEVDGLEVCKRLREQESENPIILLTAHGSKNDILLGFDAGADDYITKPFNSDELRARVRV-------
+---TTMIWVVDDDPELRQMVGTYLIDQGYE-VRCLSDVKQFEARLDFQRPDLVVLDLMMPGDDGLTALRRLRDADDDLPVVMLTAKGDGIDRIIGLEQGADDYLAKPFLPRELSARIEAVLRRR--
+--TTMHVLLADDASVNGTILREQLDVLGCA-VHVVGLAGAALDLLYRSDWDLLLIGTDLPDMAACALAEAVHARGMPCSVAIVTTHLAPDDARRCAAANVQSVLTKPVTLVRLRSVLAGVARRRG-
+---TTLVYVVDDDAGMLESTQWLLESVGLA-VEAYSDGRKFLDSMTAQSNGCVVLDIRMPGLGGLNVQEELQKRGLALPIIFVSGHADVPIVVRAFKSGAFDFIEKPFNEQLLLDSVQQALQER--
+----TTLVLVDDEPSLREPLAEYLTGQGFV-VREAESAAAARSLLGSEAPDLVLLDIMMPGEDGLSLCRHLVET-RHLPVILLTAKGEAMDRIIGLEIGADDYVTKPFEPRELVARIRSVLRRA--
+--TTLSVLVVEDNEDINNYITSLLDD-KYR-IYQASNGEEGIKIAKEILPSLIISDIMMPIKDGFEFSQEIRSSTAHIPIIFLTAKAEDIDIIHATHIGIDDYLTKPFNSEILKAKVDNLISQR--
+--TTLSVLIVDDNASVRKALYEAGRSFGWH-TACASGAGQARALLIERPYDLLLLDQDMPGTDGPALLQQLPPELALPPVLMMTSEHRAAIAQQTATLGLAGVLAKPVSPARLLERVSALLA----
+---------------------------------------TTLSALSQSKIDGILLELGSPHTPSLQLLSQLKKQ-TNAPIIVIDGGD-TEIAVQAFKNGADDYLIKHTTPDDLCLAMRTAIENA--
+--TTLRILYIEDNPANMQLMANIIETLGCE-LVIAPNAEDGITKAQQFLPNIIFIDINLPGMNGDEALPILKAEAQNTLFYALTANAMKEDVKKGLIQGFDKYLTKPINVAEILSIIKE-------
+--TTLRILLVEDDLPMAQALQEALGRHGLL-VDCVHSLAAAGATLRLNVHDLLILDRGLPDGDGVGFIATARRLCPALPIVLLTARGEIAERVDGLDGGADDYLVKPVAVDELLARVRAIARR---
+----TTLMIVDGHELIRHGVRQILEEQDLSVVAEAGDSVTAVTVSTAVRPDVVVLDIEIPGGDPVGTVRRIREGSPDTAVIILSMLDGPELVRDLLEVGVRGYLHKSVARHDLVSAVRAVSRDR--
+----TTLMIVDGHDLIRHGVRQILEEQDLSVVAEAGDSVTAVTVSMAVRPDVVVLDIEIPGGDPVGTVRRIREGSPDTAVIILSMLDGPELVRDLLEVGVRGYLHKSVARHDLVSAVRAVSRDR--
+----TTLLVVEDDEAILHLIDVALTMNYYK-VVTAKTGKEADFRLRTEQPDIILLDLGLPDIDGLSLIQQFRD-FVDTPIIVISARTEEQTIVEVLDRGANDYMTKPFNIDELRARIRVALRM---
+----TTLLVVEDDEAILHLIDVALTMNYYK-VVTAKTGKEADFRLRTEQPDIILLDLGLPDIDGLSLIQQFRD-FVDTPIIVISARTEEQTIVEALDRGANDYMTKPFNIDELRARIRVALRM---
+----TTLLVIEDDDAISHLIDVALTMNYYK-VIKAKVGKEANFRIRTEHPDIILLDLGLPDIDGLKLIQQIRE-YVDTPIIVISARTEEETIVKALDYGANDYMTKPFNIDELKARIRVALR----
+----TTLLLVEDEAALADSLTTEFELENMS-VIWAKDGAEALTLFKNNKINVIILDWMLPKLDGFSVLRKIRQS-SQVPIIMLTARDYIGDKVAGLTGGADDYITKPFEMEELVARVEVALRHN--
+----TTLLLIDDDPNLILLVRDYLEFRGYD-MLTAANGVEGLQILEETTPDLIICDVMMPEMDGYTFIQNVRQQISWIPVIFLSAKGQTCDRIEGLNQGADVYLVKPFEPEELVAQVESSLNQA--
+----TTLLIVEDDREIRSLLADFLGREGYD-TRLAADGRAMDAILAGIRPDLVILDIMLPGEDGLSLCRRLRAQ-GDVPVLMLTAKGDEVDRIVGLEVGADDYLVKPFNPRELLARIRAILRRV--
+----TTLLIVEDDPVSRKILSAAAEDEGFV-VHACPDAESGWEFFQQQQPWIVVLDWRLGGLNGVGLARKIRDSGHYVTILMVTVQERPEDMEEALKAGVTYYMTKPVKRDYFQAWL---------
+----TTLLIVEDDPVSRKILSAAAEDEGFV-VHACPDAESGWEFFQQQQPWIVVLDWRLGGLDGVGLARKIRASGRYVTILMVTVQERPEDMEEALKAGVTYYMTKPVKRDYFQAWL---------
+----TTLLIVDDNPDDRLTFKRYLNRYEYQ-IIEASSASEGLELVKTFDIDGILLDFRLPDEDGLEFIQQLKQHNNSCPIIMLTGVGNQSVAVEAMKNGVHDYLVKDITPDNLHKAIQNSLEKF--
+----TTLLIADDHPLFREALRGAVQRVGVQ-LLEADNVDALYTLADAQPADLLLMDLNMPGAQGFSALVHMRSLHPQLPVVVVSAREEPTVMRRAIDHGAFGFIPKSADSDTIGRALATVLD----
+----TTLLIADDHPLFREALRGAVQRVGVE-LFEADNVDALYTLADAQPADLLLMDLNMPGAQGFSALVHMRSLHPQLPVVVVSAREEPTVMRRAIDHGAFGFIPKSADSDTIGRALATVLD----
+----TTLLIADAHPWTRLGLSALLNAVGLSVVAQAADSETACALAESAEPDIVIIDTDFPDLGGAETIQRILEADPENPALLVTSTVDDNDIYAALHAGARGILLKNIPPEQMTAAVTAAAR----
+--TTLKILVAEDNRTNQKVALRLLELLGYR-ADVVNTGIEVLTALEHQRYDVILMDMRMPEMDGVEATQRIRHHHKETWIIAMTANTMDSDRELCLSVGMDDYLCKPIKRDALELALE--------
+--TTLKILLVEDYEDNRFLMLMLLETLGYQ-ADWVTNGQEFLDQTEEQDYDIVFLDCQMPILDGYEAIKRFRQEGNHTVVIGLTAHAMEGDRDKCLEAGMDDYLSKPILIESLANLLEK-------
+-------------------------------TTLIEGCLSLLQHAIDDKPSLILFDVEVPVEEALCRLGELRA-ARFIRKVILTSHSDLDDKVDALEAGADDFLEKPISTRELIARIDAVLRSS--
+----TTLALVDDDENIVASLKMFFEAEGYQ-VRAYHDGESALPALTDSPPDIAILDIKMPKMDGMELLRRLRQT-SELPVIFLTSKDEEIDEVIGFNIGADDFVRKPCSNRLLAERVKAVLRRS--
+---TTKVLVVEDSVTSRNYICSLLKKFQFQ-IYEASDGLEALNLLAEHQIRMVISDHRMPNMDGYELIKAIRHRMQDLIFIGLSGTNDGVLSSKFIKSGANDFLSKPFYHEEFFCRVMQNLEA---
+---TTKVLVVEDSRTSRNHICSLLRKFQFQ-VHEANDGLEALEELDNHRIKMVIADHRMPNMDGYELVKAIRHRMQDLVFIGLSANGDSVLTSKFIKSGANDFLSKPFYHEEFYCRIMQNLESQ--
+---TTKVLVVEDSKTSRNHICSLLRKFQFQ-VHEANDGLEALEVLDNHRIKMVIADHRMPNMDGYELVRTIRHRLQDLVFIGLSASGDSVLTSKFIKSGANDFLSKPFYHEEFYCRIMQNLESQ--
+--TTKTVMVVDDSVTVRKVTTRFLEREGFN-VITAKDGVDALRVLQDDDPDLMLLDIEMPRMDGFEVAKNIRSRLRHLPIIMITSRTGDKHRERAMSLGVNKYLGKPYQEELLLSSIAELLEEA--
+--TTKTIMVVDDSITVRKVTTRLLKRHGME-VMTAKDGLDAIAQLQERIPDLMLLDIEMPRMDGYELATQVRNDWEHLPIIMITSRTGTKHRDKAEQIGVNRYLGKPFNENELLKNIQGLLV----
+--TTKSILLADDSPTVLRTMQLILNKLGVI-HHDFINGKHLLDYLFSNSIGMIITDLEMPEASGFEVIKQVKSATAHLPIVVNSSMSGSSNEDMARSLDADEFISKS-NPVEIEAAVRKF------
+--TTKNILLIEDEDPVRIFATKALVKKGFN-VIDINCGDKAIDIIKNQNIDIVISDVVMPKISGPEIIDQILKIQPNIKVIFISGYAEEFNKHSNIDASKINFLSKPFTLKQLTEKVSEIL-----
+--TTKKVIFADDSRFIRKMVVELFHALNVN-YVMYTNGKELIDGIKNDEIGLFITDLEMPVMGGREVMKFIRDSYDSIKIIVHTNMSNDSMKENLATAGADKIIGK-VNMLKLGEAIHEL------
+--TTKKILVYSDNSDVRESVKRAVGKVGHTSVEGATPDGTILKIREAEPFDLLILDAETPKLGGIGLGKMVRDENEEIPYIVLIARPQDEWLARVA--RPEAILNYPTDLPQLTTSVESL------
+---TTKIVIIDDHQLFREGVKRILDETNFHVVAEGDDGEEALELMEKHDPDVIIMDINMPKVNGVEATRRLVEANAEAKVIVLSIHDDENYVTHALQTGARGYLLKEMDADALVDAVKVVA-----
+---TTKILYIEDNRDNQRLVERVLGARGYH-VLIAEDGPSGISLARESHPALILVDLGLPGLDGYETTTRLRSHLTGIPIIALTADASNEAREQALVAGCDGYLTKPIDTRQLPNQIAEFL-----
+----TTIVVADDQAMIRAGLVALLSEPDLRVLAEAADGQAAVAAVQRRRPDVVLMDVRMPGVDGITAAREIVDTDGQTSVIMLTVHDLDEYVYAALRAGASGFLLKDAPPEELVRAVHTVA-----
+----TTIVLADDHPIFRDGLRKTLDDSGFKVLAAGCDAEEAVRLTREHRPDLVILDLSMPG-GGLGATRQIAALGDAPRIAILTVSEDSNDVADALEAGATGYILKGVTASALTKSLRSIAK----
+----TTIVCVENDPAILDGMKTLLRGWDAN-VIASVDPKQACRAIASEPITGLLVDYHLDRGNGIAAIRDIRHKGAHIPAILITADRSPPVREAARAYGI-VVLNKPVKPATLRALLSQWRNQ---
+----TTIVCVENDPAILDGMKTLLRGWDAN-VIASIDPKQACRAIASSGITGLLVDYHLDRGNGIAAIRDLRHKGANIPAILITADRSPGVREAARSYGI-IVLNKPVKPATLRALLSQWRA----
+--TTIRVLYIDDEENNLHAFKASFRR-QYE-IYTALSAVEGLKILENVPVQVIIADQKMPNTTGVEFFKSIKNTFPDPTRILLTGYTDIEALADAINHGIYRYITKPWNDLELHNSIKNAYD----
+--TTIRVLLVDDQELVRAGFRMLIDQPDLSVVGEAGDGQEAVAALTHTEADVVLMDVRMPRMDGVEATGLIAGREGAPRVIVLTTFDLDEYAFAAIRAGAAAFLLKDARPEDLLTAIRTVH-----
+--TTIRVLLADDQALLRSAFKVLVDESDMEVVGEASDGAQAYALARERGADVVLMDIRMPGTDGLAATRMISAELAGVRVVMLTTFEVDEYVVQSLRAGASGFLGKGAEPEELLNAIRVAA-----
+--TTIRVLIADDQMMVRQGFTVLLNEPDIEVVGQAVDGADAIDQVAELAPDVVLMDIRMPGVGGIEATRRLTEAGATVKILVLTTFDLDEYVYEALRAGASGFLLKDASADELAHAVRVVA-----
+--TTIRVLIADDHAIFRQGLATIINDPEMQVIAQAENGEQAIALFGEHQPDVTLMDLRMPEVEGVAAIGAICALVKSARIIVLTTYDSDEDIYRGLQAGAKGYLLKDTEPDELLNAIRTVHR----
+--TTIRVLIADDHAIFRQGLATIINDPEMQVIAQAENGEQAIAAFREHQPDVTLMDLRMPEVEGVAAIGAICATAKSARIIVLTTYDSDEDIYRGLQAGAKGYLLKETEPDELLNAIRTVHR----
+--TTIRVLIADDHAIFRQGLATIINDPDMQVIAQAENGEQAIALFEEHQPDVTLMDLRMPEVEGVAAISAICAIVKFARIIVLTTYDSDEDIYRGLQAGAKGYLLKETEPDELLNAIRTVHR----
+--TTIRVFLVDDHLVVRAGLRALLNQPDVEVVGEASSGEGAATAIPSASPDLVMMDLDMGGMHGAEAIKRLRSDGVDVPVLVFTTYDTDADVVRAVDAGAIGYLLKDSTPDEIFGAVRGAVA----
+--TTIRILLADDHALVRRGVRLILDREDLEVVAEAGDGAEAIAMARTHEVDLAVLDIAMPRFTGLQAARELAAVRPGVRILMLTMHDNEQYLFQALKAGASGYVLKSVADRDLVAACRAAMRD---
+-----------------------------------TTIRDALTGIRQNAFILTLTGVETRDEAQLRLISTLRATTRHCGILVLQSRPHPAGAAHALDLGADDLMQHGFDIDELSLRLTGLLARK--
+----TTIMIVEDEWAIARVLDAYCKKRGWH-TVMVEDGHQVMAVFLDASPDLVLLDVMLPGRDGWSILSEIRER-SDCPVVMLTALDELDDRLKGFDGGADDYIAKPFHGEEVVARIAAVLKRQ--
+----TTILYIDDEPLVADASVRFLTHSGFE-VDKALSGREALEKLRAGRYDAVISDYHMPGMTGIELLKIIRSDIGDIPFILFTGKGREEVVIEAIEHGVDYYVQKGGTPG---------------
+----TTILVVEDEPAIQELISVNLSFAGHK-VLRAFDAEQAQTLIRAELPDLILLDWMLPGASGITLARTLRSRTRHVPVIMLTAKGAEHDKVEGLEAGADDYITKPFSPKELIARIKAVLRRR--
+----TTILVVDDSKSMRRIIVDSLKDEGYE-CRSAEDVDTALIALDGCEFSLVLCDIEMPGRNGIFLLNEIRTTRPDTYVVMLTGVTDPETVMHCIHLGANDYLMKPFTLERLLLTVRNALQQR--
+----TTILVVDDIEPNIKLLTAKLLQEYYT-VLTANSGKEALAILKKEKIDIILLDVMMPEIDGFEVCKTIKTATTHIPVVMVTALSDIDDRVKGLEAGADEFLTKPINDTALFVRLKSLSRM---
+----TTILVVDDHPLLLSGLGMLLNEEDLEVVGQTDRAESALTLAGELEPDIILLDITLSDTSGIDLLPRLLEITPQSQVIMLTMHENQRYLQLAMQAGARGFVLKKGLDADLLYAVRTVYR----
+----TTILVIDDSVTVRRTLQRVLGG-SFR-LIQCRDGKEAWDLLNRQNIDLALCDIEMPNMDGFSLLQLVRAHWHSLTVVMLTSRENPLHRNRAKALGADGYLTKPFQPNQLLSTIDQFLAES--
+----TTILLVDDHPVVREGYRRLLEQPGLSVIAEADTAAEAYRLYKAHAPALVILDLSLPGPSGIEAIRHIRQWDRQARILVFTMRQGAALAAKAFEAGAAGYVTKASPPRELVEAVGTVMR----
+----TTILLAEDDAVSRILIKRSLQEENLT-ILDAWNGRDAVQMIMQHPIDLVLMDIKMPVMNGFEASREIKKLRPELPIIAQTAFTSKEERLKALEAGCDSFMSKPINKQKLIELIRLLLH----
+----TTILIVEDEQDLLDTLEFNLQREGYA-TRRAASGRAGLEAAALEPPDLVLLDLMLPDISGTEVCRQLRARTRSVPVVMLTARGEEVDRVVGFEVGADDYVTKPFSVRELMLRVRAILRRAG-
+----TTILIVEDEPSIAELIAFTLKEAGWS-SFVVSNAAAAWDFVQHRAPQLVLLDWMLPDRSGLHLLSRIRAQLQQLSVIMLTAKSMEEDKIAGLDNGADDYITKPFSPRELTARIKALLRRK--
+----TTILIVEDEFLIAVEMEAVVHDLGHESAGIADDMQSALAKAS-DAIDVALVDVNLAGATGPRIGEKLAAD-FGIEVIFVTANP--AQLGEGV-SGTLGALEKPVDLSILKQVLDYVI-----
+----TTILIVEDDRNLAGLLKYNLEKAGYS-CLHAATGEEALEQLRQHAVNMVLLDIMLPGIDGFEVCRRIRQQWSDLPIVMLTAKGEEIDKVFGFELGIDDYVVKPFSPRELNLRIRAILKRD--
+----TTILIVDDHPPVRAVLKTHFSQLGITHVLEADNGQAAIEIVRQYLPDVVILDLDIPKINGLDVIPRLKASHPAVRILVISGQDQNAFAPRARHAGAHGFVSKTQELAEIVRCTESVLA----
+----TTILIAEDSRVQRKILDNHLQTLGYN-VLSASDGVEALEIFRAIQPRVVITDLEMPNMDGFELIRQIRKHIQYTHITVLSSLAEKENIIRAISLGASDYLVKPFHPDEMRVRLE--------
+----TTILIADDDSNIRELLRFILQREGFR-ALEAADGEEASRVMRQEDVALAIVDVMMPEKDGLMLCEEIRRD-YDIPVMLLTARGELDDKARGFRSGTDDYMVKPFEPDELLYRVRALLRRY--
+----TTILIADDDAVQRRLVENMVQKCGYR-TVVVDSGDAAIETLTADDIDAVVLDLVMPGLDGMGVLERMRDAGLSIPVIVQTAHGGIDNVVSAMRAGATDFVVKPVGIERLQISLRNALNAS--
+----TTILAIEDDPVLGAYLQEELQRGGCQ-VTWCRNGLEGLETAGRQAFDVVLMDILLPGLDGLDALAQLRRH-SATPVIMMSALGAEADRISGFQRGADDYLPKPFSMAELQVRIEAILRRVA-
+--TTIHVLVVEDHEDDFRYLAFLLGRSGYH-LSWASSYAAGQAMLRQGGFDVGLFDYRLGGGTGLDLLREAHETGCTIPIILLTGHDSAEVDQEASQAGAADYLCKTLTGTELERTIRYAMRHAA-
+----TTIFYVDDDEDDRMFFEEVTQQIGEK-ISLFEFGDQMLLQLENPPPSVIFVDLNMPIKDGFEVLQEIKKNLKNIPVIILSTTNNSDTVNRCLDLGASLYVQKSISLKDLKKSLEYVI-----
+--TTHTLLLVEDDPADAHLVRLACEECGNSCIHHVKDGLEALDFLERRPPDLVFLDLNMPRMSGVDFLREIDRQFKQIPIVVLTTSDAGTDVDTAFSLGCRGFITKPMDMEQLCYQIR--------
+--TTHTLLLVEDDPADAHLVRLACEECGCR-IHHVKDGLEALDFLERRPPDLVFLDLNMPRMSGVDFLREIGRQFKQIPIVVLTTSDAGTDVDTAFSLGCRGFITKPMDMEQLCYQIR--------
+---TTHLVIADDHPLFRNALRQAVTSVLAEVVDEAGSFEDLTTLLEKDEVDLVLLDLTMPGISGFSGLIYLRAQYPAIPVVIVSASDDGATIRRSLDFGASGFIPKRFGVDTLRDAITKVMD----
+---TTHLLLAEDEAALGQIVKESLETRKFT-VDLAEDGEKALKLFEQKSYDALVLDVMMPKKDGFTLAKEIRAKDDSIPIIFLTAKSQTSDVVEGFSIGGNDYLKKPFSMEELIVRIHNLVARK--
+---TTHILVVEDDPAIGRLLLMHLREAGWQ-AILANTGMTGLRLWASDCFQIVLLDVMLPDLSGWELCQQLRAE-SNVPILMLTAKASDDDVVRGLNLGADDYLTKPFSQAQLIARVQRLIQRQA-
+---TTGILVASDQILLRAGLRELLHEPNLDVVGEALDENETIYLTGRLEPDIVLMVVLNRREASIGVTKRLKAQHPDIGVILVTSCEDTTFARDIIRAGASGYLPTRAAQSELINAIHAI------
+--TTFTVLCVDDEVNILKAIKRVLHRQDFK-LITAESGAQALEILKQESVQVIVSDMRMPNMSGAEFLQKSTEIIPDCYRILLTGYSDMSSTIDAVNKGIDRYLQKPWDNHELITTVNDGLAKI--
+--TTFEVLLVEDDNELAELIQDFLQCYEFN-ITIVTDGITAVKTILDQQPDLVILDIMLPGQSGMEVCRAVRSQ-YSGMILMQTALDDDIDQVMGLELGADDYVVKQIKPRLLLSRIRALLRRQ--
+-----------------------------------------------TTFDVLIVNISLS-KDLLRLCSAIKSKTRSIPIIAIVDDEDESLITEITELGINDYICVPVNKSEFIARVTTQVKRK--
+--TTATILVADDDRGIRTVLSQALGRAGYE-VRTTGNASTLWRWVSEGEGDLVITDVVMPDESGLDLLPRMKKIRPELRIIVMSAQNTLLTAVKATQRGAFEYLPKPFDLKELVNVVGRALS----
+--TTATILIVEDDPDVRQAVSLWLTASGYA-VATADDGRTGLAAIREHKPDAVLLDLRLPGLDGFDVLKALAREGKPPPVIVISGQDEIQGVIQAFRLGAADYLQKPVSFDLLGHALEAVLERQ--
+----TTALVVDDSKVSRNAFRTDLEKLRIN-VLEAEDGKEALAIMDNNNISLILTDYNMPNMDGVELTIKLRQKKDVLSIIALSASEELNILSDFIKEGANDFISKPHKFEELNVRVHSNLD----
+----TTALVADDMPLARAMLSNILLAQGIGRVIVVEDGKKAISRFLADAPNLVLLDIDMPKLDGLEALRQIKECSPGVFACLVSSNSTRVNVQLAREFGVDGFLVKPYTPLNLKRILARY------
+--TTAKVLVVEDEKALSADIVELIEPI-CE-TTTAFDGEQGEFLASQGVFDAIILDLMLPGESGLDLLLHIRNQGVKTPVLILTAKDTIADKLRGFNDGADDYVTKPFHREELLARMKALLKRTG-
+--TTAKLLIVDDLPENLLALDALIQGEDRE-VHQAQSAEAALSLLLEHEFALAILDVQMPGMNGFELAELMRGKTKHIPIVFVSAAGRENYAFKGYESGAVDFLHKPLDTLAVKSKVSV-------
+--TSYTILVVDDNSDLTDFFSKALSEYFKK-VLIASDGVEALQLVKSYTPDIIVSDVMMPRMNGYELCKGLKEAVSHIPIILLTARDDKESQISGYKNGADGYLTKPFEIEMLMELIRNRLKN---
+--TSYTILVVDDNSDLTDFFSKALSEYFKK-VLIASDGVEALQLVKSYTPDIIVSDVMMPRMNGYELCKGIKEAVSHIPIILLTARDDKESQISGYKNGADGYLTKPFEIEMLMELIRNRLKN---
+--TSYSVLAVDDEPSIGKLLEKELSTPARA-VHVAGSARQARERLRRATYEVVVLDIRLPDADGIEFMVELRQRYPDMEVILITGHGNIDNAVEAMKLGAYDYITKPFNLTELEVVVERAYQRA--
+--TSYRILMVDDELPVLLTIKRRLRM-HFD-IVSVLSPTEALQRIATKPFDIVISDMRMPEMSGIEFLSRVRKIDPSIARIMLTGDLDRETLLQAVKAEVSKFLEKPVSSDQLCEAIMETAAE---
+--TSYRFIIADDHPLFRGALRQTLETQYPDVIEEAGALEDVTARLEQGEVDLILLDLSMPGMRGFSGLMYLRAQYSGVPVVVVSANEDPQAIRRAVEFGASGFIPKSHGIDVIREAISEVMS----
+--TSYKILLAEDNLVNQKLAVKILENHGHS-VEVVENGQEAVEAVKKNHYDVILMDVQMPIMGGFEATAKIREE-KRTPIVALTAHAMLGDRERCLKAQMDEYLSKPLKPSLLLQTISKCIHNM--
+--TSYHILVVEDDPVGRQTLAAYLVKDNHR-VSEAGDGEEMRRIFARGDVDVILLDINLPGEDGLSLLRELRRQ-SEVGVIMVTSRREDVDRIVALELGADDYVTKPYNMREILPRTRNLARRVT-
+--TSYHILVVEDDPVGRQTLAAYLVKDNHR-VSEAGDGEEMRRIFARGDVDVILFDINLTGRRTGSLLRELRRQ-SEVGVIMVTSRREDVDRIVALELGADDYVTKPYNMREILPRTRNLARRVT-
+--TSVRLLLVDDDPSLLKLLGMRLRSEGFT-VVTAGSGPEALRVLNRENFDLTISDLRMDEMDGMTLFVEIQKLKPGMPVIILTAHGSIPDAVAATRQGVFSFLTKPVDRDALYKAIDEALAH---
+----TSVMIVEDEPIIAADIESLVESMGHEVTGIATTRSEAIELAKKQTPGLILCDIQLADSSGIDAVHDILGE-IDVPVIFVTAFP--ERLLTGEKPEPTYLVSKPFQENTLIATIGQAL-----
+----TSVMIVDDHEVVRRGIADMVDAAGLRVVAEAGSVADAVRRGTLTRPEVALVDLQLPDGTGIEVIRRLADESSDTRCVVLTSFDDDDALASAIEVGARAYVLKTVRGAEIVDVVRAVA-----
+----TSVLVVEDNVEVGTFATQTLAELGFG-TVWAANAAEALAELAKDSFDVVFTDVMMPGMNGVDLAREIQRLHPDLPVVLTSGYS---HVLARTGTNGFELLQKPYSVEQLSRTLQAVAK----
+----TSVLVVEDNVEVGTFATQTLAELGFG-TVWAANAAEALAELAKDRFDVVFTDVMMPGMNGVDLAREIQRLHPDLPVVLTSGYS---HVLARTGTNGFELLQKPYSVEQLSRTLQAVAK----
+----TSVLVVEDNKINRQIAKELLEGVGVR-VTLAGDGLEALALVENYDFDLIFMDIQMPRMDGLEACRRIRQHKKQPPVVAMTAHALAGDRETSLRAGMNDHITKPIDPDELYAALANWIKRN--
+----TSVLVVEDDVAIRDMLSFTLKQAGFG-CDSVGDGEAGLDFLKKQQPDMILLDWMLPGIDGIEFIRRLRANLANIPVIMLTAKGESEDMVKGLAVGADDYVNKPFSPPELMARIRAVLRRC--
+----TSVLVVDDNAENRVLLSGLLKPH-HR-VLVATGGVQAINICKQKKPDIVLLDVMMPEMDGYEVCERLTSETHDIPVIFLTAKSQIEDEQRGFAAGAVDYILKPISPPILISRINTHLR----
+----TSVLVVDDEPAIHRFMAPALAANGYD-ALRADTGTQALALVVNRRPDIVVLDLGLPDMDGKEVIRRLRE-WSDVPIVVLSARDREIEKIEALDLGADDFVNKPFGIGELMARLRAALRHR--
+----TSVLVVDDDKTTRTLMKRMLERMGCT-VTVAENGAVALKLMGEVRFDVVFMDNQMPLVSGMGVARRLRAIGRDDFLVGVTGNALQTDQREYLDAGVNRLLTKPVLEKNMREML---------
+----TSVLVLEDNVDDYLLLSIAVKKTALPILHWVHSPSEALAYLHGEGPCLFLTDLNIRTYSGLELIQKIRQRYKDLYIAVLSGSLDEHQIILVYEAGGTVFLNKTSAMNELISMMHGLLAQ---
+----TSVLVISTNPALVDGAQAYADNNKLH-IEFCSNTRDALNLAQQHAFSVAIDDGSSDDGHLFEASQKLQASMPDLTLIIAENDTESISPRELVRLQAYSYLEKPFRKSALKQAIDAAIEA---
+----TSVLVIDDEPELAEYTAKYFNMSGVE-TQYVLTAQDARDFLKKNTCSLILLDINLGNDSGFDLCSEIRT-CMDVPIFFISARAAEDDMLLALSIGGDDYICKPYSLGVLLAKVRAVLKRY--
+----TSVLVIDDEFEIRTVLERVISKEGYQ-VLSAKDSDSALEIIRNQKVDVVISDIVMNGKSGIEVVKEIRKINENIPVILMTGNPDLNSAEEAVRNRAFDYISKPIRRRNILEILERA------
+----TSVLVIDDEFEIRIVLERVISKEGYQ-VLSAKDSDSALEIIRNQKVDVVISDIVMNGKSGIEVVKEIRKINENIPVILMTGNPDLNSAEEAVRNRAFDYISKPIRRRNILEILERA------
+----TSVLVCDDSKLARRQLARSLEDWDIK-VEFAINGVDCIKQIKAVDPEILFLDLNMPEMDGYEVLMAMKELGLNVLTVVVSGDIQPNAHQRVLDLGAIDFIQKPCSPEKLAEIIEH-------
+----TSVLLADDDARLRQFLELELREEGYA-VHSCGDGIGALTQIRQEPPDLLVLDWMLPDLSGVEVCQRLRSTGVQVPVLMLTGRDAVKDRVEALDAGADDYLVKPFSIEELLARLRALARR---
+----TSVLIVEDEPSILELISYTCRTSGME-VRKAANVAEAKKNLEAAKPDIILLDWMLPDCAGLDWLRELRSSNESLPVIMLTARGQEDDRVRGLEAGADDYVTKPFSPRELVARIRAVIRRKG-
+----TSVLIVEDEESLADPLTFLLRKEGFE-ATVVTDGPAALAEFDRAGADIVLLDLMLPGMSGTDVCKQLRAR-SSVPVIMVTARDSEIDKVVGLELGADD------------------------
+----TSVLIVEDEESLADPLAFLLRKEGFE-ATVVTDGPAALAEFDRAGADIVLLDLMLPGMSGTDVCKQLRAR-SSVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRG--
+----TSVLIVEDEESLADPLAFLLRKEGFE-ATVVTDGPAALAEFDRAGADIVLLDLMLPGMSGTDVCKQLRAR-SSVPVIMVTARDSEIDKVVGLELGADD------------------------
+----TSVLIIEDEPIISMDLEQIVRDLGHDIMATVVTREEAVSAISKNKPGLVLADIQLAGSSGIDAVKDIFAR-FRVPVIFITAYP--ERLLTGERPEPTFLITKPFLPSTVKAAIGQAL-----
+----TSVLIIEDEPIIAADLANLVEDLGHTFAGNAATRKHAVELARRVKPGLILCDVQLANSSGIDAVQDILAD-FDLPVIFITAFP--ERLLTGERPEPTYLITKPFQDDTVKAAISQAL-----
+----TSVLICDDSKLARRQLARSLPDWDIK-VEFACDGVDCIKQITKAQPEILFLDLNMPEMDGYGVLAAMKEQGLDVLTVVVSGDIQPSAHQRVLELGAIDFIQKPCSPEKLAAIIEH-------
+----TSVLICDDSKLARRQLARSLPDWDIK-IEFAHDGVDCINQIKKIQPEILFLDLNMPEMDGYEVLIAIRELGLNVLTVVVSGDIQPAAHERVLELGAIDFIQKPCSAEKLATIIEH-------
+----TSVLICDDSGFARRQMARSIPGWDVD-IHFAENGKEAISAIKQGKADVMFLDLNMPVMDGYQTMQIVKEQDLPTLVIVVSGDVQPEAHKKMLSLGVIAFIAKPIDNQKLCEILRQ-------
+----TSVLAVDDVPDNLEVIARVLRNRGAT-VTTALSAAEAIKTLETTKYHVLVSDIAMPEMDGFDLIAATRRHCGHLPAIALTAFARQEDGDRALAAGFDHFLSKPVDPVELVAAICRCT-----
+----TSVLAVDDDRVHAYAMEKKLRASGFV-VKCVHSGPEALAELRSGKYDAILLDINMPGLNGYQTCERIRSEIPQPAIIFHSASDASEAVHRAYDAGADAFLTYPVDDEQLKAVL---------
+-------------------------------TSVASDIGEARSRLDNVPVDCVISALSPPDGSAIDLLRSIREDRPHLPVVIYARSGDEECASAAIGAGATDYLPADTSPAELRDRAARA------
+---TSTVVIADPKPLSLLATAGVLHHEGMR-CICARSTDAVLKAFEKFAIDLLIWDVADDPMSVLTIVQQIRQPFQNLPVVLLADSKWAGLEKKTSEIAPTHCLFKPIDPKSLITIAQHLL-----
+-------------------------------TSTVMSADPAIDNVQDFRPEMVLVDIRLGARTAFERLSIVREWFPDLPMVVIGNESGAHLILTAMRAGAQDFLDRDAADEDVRNVVARHIA----
+---TSTVLVVDDDDALAEMIGIVLAQEGYN-AVFCENGSRAFETFMRHSPDLVLLDLMLPGKSGIEVCEQIRSS-SNVPIIMLTAKSDTEDVVKGLEAGADDYIAKPFKHLELMARIRARLR----
+-------------------------------TSTVEDGEAALEVLTHKDIQFVLSDLMMPGLSGIDLCRLLKSAERYIFFVLLSSRNDQGSIVKGIDAGADDFVDKKTSVEELQARIRAGFR----
+--TSTTILLIEDEDPVRIFATKALTKKGFK-VIDISCGDQALDIINKYPIDIVISDVVMPKISGPEIVEQILKAKPDIQIIFISGYAEEFNKHSNIDATKINFLSKPFTLKQLTEKVLEIS-----
+---TSTILVVDDSAALRRTLALTLQKAGYR-VMQAKDGREALQQLQQNNVQLVVCDVEMPNMNGFEFLGQRRRELMNIPVAMLTSRSSEKHRQLATHLGASAYFTKPYIEQQFLTAVDNIVKS---
+---TSTILIADDDPGARLVLQRLLTREGHR-VLMAQNGAEALRQSIEYTPDLLLLDVLMPEIDGFEVCRQLRNRLREIPILLITSLGDQQSRVEGLSAGANGFITKPFDMAELLAHVRTITR----
+--TSTHILVVDDHKDIRDLLAKFLVKHGMR-VTVAADAAEARRHLKAGAFDLLVLDIMMPGEDGISLCRDIRDS-NSAPIIFLTAVAEDTDRIIGLELGADDYVTKPFNPRELLARIRAVIRRA--
+---TSSILIVDDEPNIAYLLRECLLAQGFN-VKEAHNPTDALAVVTKEPPDAMILDVMLPGMDGYTLLRRVREMGTECPVLFLTARDSLEDKLTGLTIGGDDYVTKPFSLEEVVARLRVILRRAG-
+--TSRRILLVEDHEDTRETLSRLLVRRGHQ-VSPAGTIRAARALAASGEFDVMISDLGLPDGEGTELLTVFANTGRKPVSIAMTGFGMEEDIRRTLAAGFVAHLTKPINIADLDRLLTS-------
+--TSPKVLVVEDEEHIRHLLKRILETEGWQ-VAEAANGMQGLEQLQTLQPDLVLLDLLMPIMDGFSFVQEMRKEWKDIPVVICTAKDLTDEDYQQLRGNVTQILHKTSN-----------------
+--TSPHILAVDDEVMLHDVFERLFPREGIE-VTACSSGTEAIELLEDAAFDLVLATHQMPGPDGMELLDHIQEHHPTVRVILLSDQDNAQNAVRAMQKGAADYIPKPFSTDELVDRVKGLLEE---
+---TSNVWVVDDDDSIRWVLERALTQAGIK-CRCFEEADSLLAEIKYEQPDAIISDIRMPGTDGLAMLDELHASLPELPIIITTAHSDLESAVASYQQGAFEYLPKPFDIDDVIAITERAISH---
+---TSMVWVVDDDPELRKMVGTYLIDQGYD-VRCLCDVKQLEARLECQRPDLLVLDVMLPGDDGLTALRRLRDAGDDLPVVMLTARGDAVDRIIGLEQGADDYLGKPFLPRELTARIDAVLRRR--
+--TSMTALIADDEPLLRHHLNRMLADVELEVVALVGDGQQALTSIEQLQPDIVFLDIRMPELDGIAVAKQLNRGEYRPTIVFVTAYD--EYAVKAFEQQAIDYLMKPLSEARLIDTCQRIKARQ--
+--TSMRILLVDDVQLDRMQLAIRLKQQGHI-VKAVGSGMEALNTYESFDPELVLLDIAMPNMNGFEVSLHIRETFPDIPIIFLSSHEEPEMIAKAIEAGGDDYLIKPVDKLVLNSKLMAMQ-----
+--TSMRILLVDDVQLDRMQLAIRLKQQGHI-VKAVGNGIEALNTYESFDPELVLLDIAMPDMNGFEVSLHIRETFPDIPIIFLSSHEEPEMIAKAIEAGGDDYLIKPVDKLVLNSKLMAMQ-----
+--TSMRILLVDDVQLDRMQLAIRLKQLGHI-VKAVGSGLEALNTYESFDPELVLLDISMPDMNGFEVSLHIRETFPDIPIIFLSSHEEPEMIAKAIEAGGDDYLIKPVDKLVLNSKLIA-------
+--TSMRILLVDDVQLDRMQLAIRLKQLGHI-VKAVGSGLEALNTYESFDPELVLLDISMPDMNGFEVSLHIRETFPDIPIIFLSSHEEPEMIAKAIDAGGDDYLIKPVDKLVLNSKLIA-------
+--TSMRILLVDDVQLDRMQLAIRLKQLGHI-VKAVGSGIEALNTYESFDPELVLLDISMPEMNGFEVSLHVRETFPDIPIIFLSSHEEPEMIAKAIDAGGDDYLIKPVDKLVLNSKLIA-------
+--TSMIVSIVDDDEHVRLATCNLLRSLGCD-VRAYSSAEAFLDSGRLGDVGCVISDVQMPGMGGIEMQRKLNEMNAALPIIFFSAFDSNATRTEALDNGALCFLDKPLNGDAVLACLEG-------
+--TSLSLLLVEDVEINRFLAERLLENAGHH-VVSAVNGIEAVEAVERENFDAVVMDIQMPELDGVEATKRIRQMKRNVPIVALTANVATEDIARYRAAGMDDCCAKPMQMEVLSPILLAI------
+--TSLRVAVFNDSATMRAAIRAALDEPDIAIVAERGDANDAAEVVARSDANAVIMDVVMPGVDGYEATRDIMRN-HPTPIVMVSSVVDAKDASAALEAGALH------------------------
+--TSLRALLVENDQVDAELLVRALTHGGFH-VTSVDTAEQMRAELARADWDVIVSDDALPTFDGMTALKLLRSTGKTIPFILMSGTVSDETAIEAVRAGARDYIRKD-QPARLVAAVRREL-----
+----TSLLVVEDESIVAMDIKHRAEGLGYRVVGMAASGEEAIKLAREEKPDLILMDIVLKEMDGIEAAEVIREE-MNIPVVYLTAYSDEKTLSRAKLTGPFGYIIKPFEDRELHSAIEVALYKH--
+----TSLLVVEDESIVAMDIKHRAEGLGYRVVGIAASGEDAIKLAREEKPDLVLMDIVLKEMDGIEAAEVIREE-MDIPVVYLTAYSDEKTLSRAKLTGPFGYIIKPFEDRELHSAIEVALYKHK-
+----TSLLLVDDDEPFLRRLAKAMEKRGFS-VETADSVAAGKAIATARPPAYAVVDLRLGDGTGLDVVETLRERRPESRIVVLTGYGAIATAVAAVKIGATDYLSKPADAADVMNAL---------
+----TSLLLVDDDEPFLRRLAKAMEKRGFS-VETADSVAAGKAIATARPPAYAVVDLRLEDGSGLDVVETLRNRRPESRIVVLTGYGAIATAVAAVKIGATDYLSKPADAADVMNAL---------
+--TSLLILVVDDEPNIRKTLTISLEAEGHR-VAAVSNSRDALMEARRRHFDLALIDLRLGAESGMELITALHASCPWMKSAVITAYASIDSAVEAMRRGAFDYLPKPFTHDQVALLVRKVVE----
+----TSLLIIEDSSDDRYLYRRLLAKYQFSSIEEVESAEEALEILQHHRPICCLLDYQLPGMDGLTFLRKLKKIDDMIPVVVLTGQGDESIAVQLMRNGAHDYLVKDLTAESLHRAIGNAVRTC--
+--TSLKVLVIEDDTEMASFIEKVLLDAGHK-VERASDGASGLAMARASEYDALIVDRMLPEKDGLTLLQEFRAAGGTTPALFLSALGDVQNKVQGLRAGAEDYLGKPFAPAELAARVEALGRRQ--
+-----TSLIIEDSLIDASLITSALEARGYGDLKVFERAEDALDYIRSDKPDFCLVDSRLPGMSGSDFIKLVKKKMDGVPCISLSTSNLKDEIRIALEAGADGYFVKPSDLEEYERVIARIIEA---
+-----TSLIIDDELFAREELADLLSSSDIEIIGQCSNAIEALQMITKLKPQLIFLDIQMPRITGIELIGMLDPD-IMPRIVFVTAYD--EFAIKAFDNYAFDYLLKPIDEKRLQQTLNRVRK----
+--TSLHVLVVEDNAVNQRLLRRQLEKAGFL-VDTANHGLQALQLLEEGAPSVVLMDLEMPVMDGLEATSRIRALPPKMPIFAITGNARQGQVDAALAVGMDEVFIKPYRLADVVARIDR-------
+--TSLHILIVEDNRTQAEYLRHLLEKRGHQ-VTVSQNGFEALERIEEKRPDIILTDVMMPDMDGYTLCKTVKQKFHDIPVILVTHLYSPVDVIKGLEAGADNFIIKPYDPEYIFSRITGIMQA---
+------TSLCDDGALQRAYIKLILQDYKFN-LYEFSSGEELLEKFNQNPFDLFFLDHRMKTITGLEAASHIRQRNQGCHIVFITASEEQG---DFKAVSPLRVLTKPAQPAAVWDILDKVAAE---
+---TSKVLLVDDEENILRAIGRLLLEDDLE-VLTATSGTEGLEVLKQHPVAVILSDQRMPGMLGADFLHQARGIAPDAVRMVLTGYADMAATMDAINKGASRYITKPWDERMLRLAIMEGVEQ---
+---TSKIFVVEDDDWYAKILMYTLSNPDYE-VIRFKSAKEVLASLH-LKPSIITLDYSLPDTKGPKLLKQLKERLPDVPVVVVSGQEDITTAVSLLKEGAYDYIVKDENTKELWKVIHHI------
+----TSIVYIEDNDTNIELMQSILSPYKNVKLLVAKTGENGIGLIRSISPDMILIDIDLPDMNGFEVCTQLQLELKHIPRVALSASAMQSDIDQAFLVGFSEYVTKPIHISTFLNVLKRLT-----
+----TSIVLVNAHALFREGLRHHLASTEFHVIGEASNGQQAIQVVDLLDPDMVVMEVDLPGVNGLEVARAIKRSHPHIRIVLLSSTMDGQEVVKAIRAGIAACVPRNIAPEKLMQTLHQVR-----
+----TSIVLVHAHALFREGLRHHISEPEFRIAGEASNGQQAIQLVDYTDPDLVLMEVDLPGVNGLEVSRAIKRTHPHVSILLFSSEMDGQQVVKAIRAGVAAYLPRNIEWPRLLTVLHEVR-----
+--TSISILVIDDDIQICELLTDTFEEYGYR-VVAVSSGQEALTLLQTNRFDLILLDLILPDINGLVLLQQLKNL-LNKPIIMLSGLNSESDVVVGLEMGADDYITKPFYPRIVVARAKAAIRRT--
+--TSIRVLLVDADSNSLLPMKNLMIQYSYQ-VTKYEDGEEAMAFLMKQEIDLVIWDFHMPDINGLDALNTIGKE-MDLPVVIMSHDHKKETVMESIKYGACDFLVKPVSKEVIAVLWRHVYRKR--
+--TSIRVLIADDQSMVRQGFTVLLNESGIEVVGQAVDGEDAVAQVAELAPDVVLMDIRMPGLGGIEATRRLTEDGATVKVLVLTTFDLDEYVYEALRAGASGFLLKDASAEELAHAVRVVA-----
+--TSIRILYVDDNNEHRDLVADALVQFRFD-VILERGASDAIDRLAAEAIHCLISEYELPDQTGLELLATVREEFPQLPFILFTGVGSEALASEAISMGVTEYLPKRYEETQHERLGNRILD----
+----TSIQVIESNPNLRSLLSWNLQQAGYH-VQQCTDMVSARDNFQAQQPNLVVLEAEFSGGQGIQLCHWLRNQ-SYPLILMLSARITEADVVTGLGAGADDYLKKPFGMKEFLARVESLTRRS--
+----TSILVVEDNMINRAILKEQLEACGAS-ITEAENGAEALDLIKVNHFDIVLSDIAMPILDGVGLIKAVRQFEPQLIMVAISGNTLHNEATAYYDAGYNYVMSKPYNTEKLYDIILKVRKRQ--
+----TSILVVEDEPAIQELISVNLSFAGHK-VLRAFDAEQAQILIRAELPDLILVDWMLPGSSGINLARKLRSRTRHIPVIMLTAKGSEQDKVDGLEAGADDYITKPFSPKELIARIKAVLRRR--
+----TSILVVDDSVTVRKVTTRLLERNGME-VRTAKDGVDAMATLQEYKPDLVLLDIEMPRMDGFEVASQMRHALKEIPIIMITSRTGEKHKERAMAIGVTDYMGKPFQEDRLLEAIAEYT-----
+----TSILVVDDDDAHRGMLRMMLQAWGYS-VDEAADGDLAVEAVRAKPYDVVLTDVRMGRMDGIHALRGILDYNPALPVVLMTAYSSVETAVDALRLGAYDYLTKPLDFDALRETLQRAVDHS--
+----TSILLVDDVEDNRLLIQRMLAKRGAN-LTLATNGQEGLTKALEKEFDIILMDIQMPVMDGYTATRKLRQAGYSKPIIALTAHAMKDDRERCLEAGCTDYLTKPVQVESLIQTILNY------
+----TSILLVDDTFVLRERLSTAMEQRGFR-VETAGNYDEAIEVFRKRPTELAVLDLRMPGKSGLELLRKLLDIAPDTRIIILSGFGSIPASIDAVRAGAVNFLSKPADADDILSAF---------
+----TSILLVDDDPIEYTIWKRKLESFELR-LEHVGDIDAAINRITEGGVDLIFLDNRLPAQDFRDTAPRLRKAGYTGPIGIISSDISGAYFREFREFGVDFRVGKDIDANMIAFIIAEYTR----
+----TSILLIDDHALFRSGMRLVLLMANVE-VLEAASLEQAVRTVTS-PPALVLLDIQLQGVNGLEGLGLFKQRWPGVPLVMLSSAAEPETIRLALSRGAAAFVSKADTAEKIIKVIEQVLS----
+----TSILIVEDEIRLAEILEDYLRREGYK-TERAKDGGRALELWRVAQPDLILLDLMLPVLDGLEVARRIRAE-SDVPIIMLTARDDEVDKLVGLGLGADDYVVKPYSPREVVARVKAVLRRV--
+----TSILIVDDEEDILELLKFNLEREGFK-IFCADSGEKALEAVKNFSPDLVLLDLMLPGIDGLEVARVLKSNTSTIPIIMLTAKGDESDVVRGLELGADDYVTKPFSPRVIIARVRAVMRRNA-
+----TSILIVDDDPDNFDVIETLLSDQNYQ-LHYTSNGTRAIASLDILQPNLILLDVMMPDMDGQQVCRAIKDKWQTLPIIMVTALDSKEDLARCLQTGADDFISKPINRVELVARVNSMLR----
+----TSILIVDDDPDNFDVIETLLSDQNYQ-LHYTSNGTRAIASLDILQPNLILLDVMMPDMDGQQVCRAIKDKWQTLPIIMVTALDSKEDLARCLQTGADDFIS---------------------
+----TSILIIEDEPLIAMDIEQLVTDIGHEVTGIARTHTEAVAEIAKRKPGMILADIQLAGSSGIDAVNEILDR-INVPVIFITAYP--ERLLTGERPEPAFLITKPFRPETVKAVISQAL-----
+----TSILIIEDDKMSQLILSRFLSGLGSR-IIVAGDGMEGLLLAKASRPDIIILDSHIPGLSGKDTLAQIRAMLQHIPVIIASGDAFKENREELLLAGADDYLVKPIEFKALQATLSKYLRAN--
+----TSILIIDDSNQVRAQIVKTLQKVSFDDYLEAADGIEAFKLVLNSPVDLILCDLEMPRMDGFKFISMLQTELKDIPVIMLTGREDRDLKIKGLEEGACDYVTKPFDAGELVARVKVQL-----
+----TSILIIDDSDQVRAQIVRTLREVSFDQYLEAGDGIDAFKTILNSRVDLILCDLEMPRMDGFKFVAMLQTELRDIPVIMLTGREDRDLKIKGLEQGACDYVTKPFDAGELVARVKVQL-----
+----TSILIADDDREIVDLVKLYLQNEGYT-IYQAYDGAEVWRLVQEKQPTLVILDIMMPEMDGLEVCRLMRKSGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQ-
+----TSILIADDDKEIVDLVKLYLQNEGYT-IYQAYDGAEVWRLVQEKQPTLVILDIMMPKMNGLEVCRLMRNNGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQ-
+----TSILIADDDKEIVDLVKLYLQNEGYT-IYQAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVCRLMRNNGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQ-
+----TSILIADDDKEIVDLVKLYLQNEGYT-IYQAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVCRLMRKNGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQ-
+----TSILIADDDKEIVDLVKLYLQNEGYT-IYQAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVCRLMRDNGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQ-
+----TSILIADDDKEIVDLVKLYLQNEGYT-IYLAYDGAEVWRLVQEKQPTLVILDIMMPEMNGLEVCRLMRSEGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQ-
+----TSILIADDDKEIVDLVKLYLQNEGYT-IYLAYDGAEVWRLVQEKQPTLVILDIMMPEMDGLEVCRLMRSEGILTPILMLSAKAEDNDKIMGLLTGADDYMVKPFNPLELSVRVKAILRRMQ-
+----TSILFADDSAIARMLVEESLKTMGVA-YSAVKNGKEAWERLGKDKVALVLTDLEMPEMDGFTLTRSIKNRFAGIPVIVYSSLTGSASEGHASGVGADAYVAK-FEPNELANAISTTLTR---
+--TSIKALLVEDIEVCRLVLSTILLAMNCE-VTLAVNGKEAVELFLEKKFDIVLLDKDMPIMTGPEAVVKIRAMEGDVKIVGVSADD--HAMEAFMNAGADAFVPKPMRREVLIPIIQEIINKK--
+---TSHVLLVEDDVEVGDLVAAMIDELGHM-VSRAANADEALAIARADPLGLVITDVIMPGKSGVDLAITLASERPELPILLSSGYTGQE-LMRAH-DTPWPLLRKPYALDALAQAMADAWDRHG-
+---TSHVLLVDDNAAEIYPLVEALRKFPFR-LTVAGDGIQAYAQAVSTVPDIILMDVRMPRRDGITTTRLLKASTQHIPILFLAAAATLEDRLEGLRSGAVDYILKPFEAEEVVEKVRIH------
+--TSHKILVVDDDPRLRDLLRRYLGEQGFT-VLVAENATAMNKLWLRERFDLLVLDLMMPGEDGLSICRRLRGANDQTPIIMLTAKGEDVDRIVGLEMGADDYLPKPFNPRELIARIHAVLRRKG-
+---TSHILVVDDDHEIRTLLAEYLDANGLR-AFVASNGSDMRRVLEQTRIDLIVLDLTLPGEDGLTLCRNLRAHHGGVPVIMLTARGEPLDRIIGLEMGADDYLPKPFEPRELFARIRSVLRRT--
+--TSFRLVIADDHPLFRGALREAVSRQQAE-LFEAGGFEDLQALLERGDLDLILLDLTMPGVRGFSGLMYLRAQYPGIPVVVVSANEEAGVIRNCMEFGASGFIPKTSAVETMREAVAAVLEG---
+----TSFLVVEDNAHMRSILRSILAGFGVRQIFDAGDGADGLEFAIERYPDVILLDWSMVPVSGSDFLRILRAQLRTTPVLIVSAQCQRSTVIEAVKLGIHGFIAKPVSPTLLYQHVVNILMRQ--
+--TSFDILIVDDQVGVRRLLFEALADEGYI-VKMAGSGAEALQVLSQTLPSLVLLDIKMSGMTGIETLQEIRKHYAQLPVAMMTAYGDMEIMDQTKSLGVQHYLNKPFDLDDVRVLVRSILSRS--
+---TSEIWIAEDDRSLRWVMEKAISREGIE-VRSFENGDDLLVALQSSLPEIIISDIRMPGIDGLELLKKIHSTRPDIPVIITTAHSDLDSAVAAYQGGAFEYLPKPFDLDELVDVARR-------
+------------------------TSEGFT-VETAESGHEGLRILGREKIDLVISDLRMDEMDGMQLFAEIQKLQPGMPVIILTAHGSIPDAVAATQQGVFSFLTKPVDKDALYKAIDDALAHA--
+-------------------------------------------------TSCLIADMHSSAMSGLELFDHLVASRGAIPTVLLTGHSEHD----VRRGPGLQFMSKPFEGSELLACVRSQIAN---
+--TSATLLLIDDDEVVRASIAAYLEDSGFN-ILLASNGLQGLEVFERERPDLVVCDLRMPQVDGLELIRRISALEYSAPIIVVSGAGVMTDVVEALRLGAADYLIKPLDLAVLEHSVRRALDRV--
+--TSATLLIIDDDEVVRASLAAYLEDSGFS-VLQASNGQQGLQVFERDQPDLVICDLRMPQMGGLELIRQVTERAPQTPVIVVSGAGVMNDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRA--
+--TSATLLIIDDDEVVRASLAAYLEDSGFS-VLQASNGQQGLQVFERDQPDLVICDLRMPQMGGLELIRQVTELAPQTPVIVVSGAGVMNDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRA--
+--TSATLLIIDDDEVVRASLAAYLEDSGFS-VLQAANGQQGLQVFERDNPDLVICDLRMPQMGGLELIRQVTELSPQTPVIVVSGAGVMNDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRA--
+--TSATLLIIDDDDVVRASLAAYLEDSGFS-VLQASNGQQGLQVFEEHQPDLVICDLRMPQMGGLELIRQVSERAPQLPVIVVSGAGVMSDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRS--
+--TSATLLIIDDDDVVRASLAAYLEDSGFS-VLQAGNGQQGLQVFEEHQPDLVICDLRMPQMGGLELIRQVSERAPQVPVIVVSGAGVMSDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRS--
+--TSATLLIIDDDDVVRASLAAYLEDSGFS-VLQAGNGQQGLQVFEEHQPDLVICDLRMPQMGGLELIRQVSERAPQLPVIVVSGAGVMSDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRS--
+--TSATLLIIDDDDVVRASLAAYLEDSGFS-VLQAANGQQGLQVFEEHQPDLVICDLRMPQMGGLELIRRVSERAPQLPVIVVSGAGVMSDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRS--
+--TSATLLIIDDDDVVRASLAAYLEDSGFK-VLQANNGLQGLEVFQQESPDLMICDLRMPQVDGLELIRRINALGVEVPVIVVSGAGVMNDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRS--
+--TSATLLIIDDDDVVRASLAAYLEDSGFK-VLQANNGLQGLEVFQQEGPDLMICDLRMPQVDGLELIRRINALGVEVPVIVVSGAGVMNDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRS--
+--TSARLLLVDDDPSLLKLLGMRLRSEGFT-VDTASSGPEALRVLNRENVDLAISDLRMDEMDGMALFVEIQKLKPGMPVIILTAHGSIPDAVAATRQGVFSFLTKPVDRDALYKAIDEALA----
+--TSARILLADDNADMRDYLKHLLQP-DYE-VEAATNGLAALAAARRQIPDLVLSDIMMPGIDGLQLLRELRSSTREVPIILLSARAGEESRVEGLEMGADDYLIKPFSARELLARVRTNL-----
+--TSAKLLIIDDDDVVRASLAAYLEDSGFS-VLQASNGLQGIQTFEQETPDLVVCDLRMPQMGGLELIRQVTAVAPQTPVIVVSGAGVMSDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRA--
+--TSAKLLIIDDDDVVRASLAAYLEDSGFS-VLQASNGLQGIQMFEQENPDLVVCDLRMPQMGGLELIRQVTAIAPQTPVIVVSGAGVMSDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRA--
+--TSAKLLIIDDDDVVRASLAAYLEDSGFS-VLQASNGLQGIQIFEQENPDLVVCDLRMPQMGGLELIRQVTAIAPQTPVIVVSGAGVMSDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRS--
+--TSAKLLIIDDDDVVRASLAAYLEDSGFS-VLQASNGLQGIQIFEQENPDLVVCDLRMPQMGGLELIRQVTAIAPQTPVIVVSGAGVMSDAVEALRLGAADYLIKPLDLAVLEHSVRRALDRA--
+----------------TRYVERELQQCGYR-TLVVPDTIDAFSLAVQSKPDLVIISALMPHLDGIDLAIALVSSTRNIPIAVITSLDSHNES----------------------------------
+--TRYTVMLLDNHEMVRQGIELGLNEADIEVIGSFGSGRELLETLAVRLADVVVMDFALGDIDGLSLIQALNRRFKQCRPIVVCSHYTPAIVSLALKAGSWGVLGKNEKLSELITAIRTAAQ----
+--TRYSVLVVEDNPTNQMVIQLILARQGHE-VFIASNGEEAIGFVERDPIDIILMDVSMPVMDGITTTKYMRDANIKTPIVALTAHTSVEDKFSCLDVGMNDFITKPVRTKEIIEAIDRLM-----
+--TRYRVLVVDDSIFVSKQIGQILTSEGYEVAGTAADGLEGVEKYKAPNVDLVTMDITMPKMDGITALEQIMDFDKNAKVVMISALGKEELVKKALLLGAKNYIVKPLDRKKVLERISNVLAK---
+--TRYKIAIIEPMEITRKNYVEWLSE-DYD-VVCISNLTSPLKELKKISPDIILMDINLSDKDYFYLLEEIKNSLRTALIIIITKRYNEDDVVNGLEKGACDYVKKPVGQNELKARIRNAVR----
+----TRVYILDSHALVRTGLRELLEEAHFTVVGESGSASEASRRIPELCPDLVVIGAHLPDGTGIEVCREILADNPGVRCLLLSSYDDDHALSSAVLAGAAGYVLRQLPGTALVEGIRRVAT----
+----TRVVVADDQPVVLQGFAAILGSVDLDVVGTAPDGRALVDLVARTAPDVAVVDVRMPVLDGIAATVRVVAEHPGTRVLILTTFDLDEYVYDALRAGASGFLLKDVTAERLVDAVRLV------
+----TRVVVADDQPVVLEGFAAILGAADLEVVGTAPDGVELVDLVTRTRPDVAVVDVRMPQLDGIAATRRIRDAHPATHVLMLTTFDLEEYVADALQAGASGFLLKDVPAARLVEGVRL-------
+----TRVVVADDQLLVRTGLTMILNQPGIEVVGEATDGHEAVDVARRLRPDVCLFDIRMPGIDGVEATRRLAGVEDPLAIVIITTFDLDEYVHGALKAGARGFLLKDAGPELLVQAIHAAA-----
+----TRVVVADDHAVVRAGLRSALASLEFEVVGEAADGPQLLAVLAQHQPDLLVVDVAMPDFEPIATIRQIHATYPAMKILVVSAYDDQSYVVGLLAAGVNGYHLKDQPLSDLQLAVQRIM-----
+----TRVVIAEDEALIRLDLKEMLEEEGYTVVGEAGDGQQAVELAREHQPDLVILDVKMPVLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYTVVGEAGDGQQAVELAREHKPDLVILDVKMPVLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYTVVGEAGDGEQAVELAREHRPDLVILDVKMPKLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYTVVGEAGDGAKAVELAREHRPDLVILDVKMPVLDGISAAEKIAGE-SIAPVLMLTAFSQRELVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGQTAVELAREHRPDLVILDVKMPVLDGISAAEKIAGE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGQTAVELAREHRPDLVILDVKMPVLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGQRAVELAREHRPDLVILDVKMPVLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGQQAVELAREHRPDLVILDVKMPVLDGISAAEKITEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGQQAVELAREHKPDLVILDVKMPVLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGQQAVDLAREHKPDLVILDVKMPVLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGETAVALAQEHRPDLVILDVKMPVLDGISAAERIAAD-RIAPVLMLTAFSQRELVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGERAVELAREHRPDLVILDVKMPKLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGEQAIELAREHRPDLVILDVKMPKMDGISAAEKIAEE-RIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGEQAIELAREHRPDLVILDVKMPKLDGISAAEKIAEE-RIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGEQAIELAREHKPDLVILDVKMPKLDGISAAEKIAEE-RIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGEEAVELAREHRPDLVILDVKMPKMDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGAKAVELAREHRPDLVILDVKMPVLDGISAAEKIAEE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVVIAEDEALIRLDLKEMLEEEGYAVVGEAGDGQRAVELAREHRPDLVILDVKMPVLDGISAAEQIAAE-SIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRF--
+----TRVTIVDDHPLVAEGIEAILDSYDISVVATLSDGQSMIDRLDELNPDVILMDLNMPGLGGLSATEMILERAPDTRILVLSMHDTPEYISTALTHGARGYVLKDVPTDEIKHAIDAVMR----
+----TRVSVVDDDPLARKIICELLNQNELSVVSSYDDGQALIDDLDRDQTDVYLCDIAMPQLDGIDTTKAIRERGDTTPIMLLTSYDVEERFIQGMQAGANGYLIKTSDISQIRAAILSIA-----
+--TRVRVILAEDDVLLREGVASLLTRSGFDVREQVGDATTLLELVRTQTPDLVVVDIRMPTTEGLDAARVIRDEFPEVGILVLSAHADVEHAMELLASGGIGYLLKSTDVDDFIDTLQRIA-----
+--TRVRILLVEDDLRVARVNRDLLERDDVHVVGSAATCAQGDALAQALQPDLILLDVHLPDGSGLGLLRHWRSAGRTTDVALITAADDESSVRLALAHGAFDYLIKPFTGQRLAELVARHR-----
+----TRVMVVDGSKLVRKLIADVLTREGVE-VIGCDSIEDAQQALAQGPVDLVTTSLTLRDGDGLALARMVRDAQAYVPVIVVSGDAQQHLEQRRFTEYVTDYFDKALGHEALATFIRGYVQ----
+----TRVMVVDGSKLVRKLIADVLRRDGVE-VIGCDSIEEAQQALAQGPVDLVTTSLTLRDGDGLALARMIREAQAYVPVIVVSGDAQQHLEQRRFTEYVTDYFDKALGHEALATFIRGYVQ----
+----TRVMVVDGSKLVRKLIADVLQRDGVE-VIGCDSIEDAQQALAQGPVDLVTTSLTLRDGDGLALARMVREAQAYVPVIVVSGDAQQHLEQRRFTEYVTDYFDKALGHEALATFIRGYVQ----
+----TRVMVVDDHPMWRDAVARDLEAAGFAVVATAGDGPQAVRRASAALPDVLVLDLNLPGLPGVEVCKRLVRERSGPHVLVLSASGEHQDVLEAVKSGATGYLLKSASTEELIDAVRRT------
+----TRVMVVDDDLSVCATLVAFLEDCGYE-VYSFNSGESAYEWIRTNRVDVAVVDLRLPAMSGDRLILNMRELLPDLPCVIYTGSPDFDPGSQYVELENVPVFRKPVDLTVLLDEIEALSQEV--
+----TRVMVIEDDIAIAELHHRYLEQMGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQ---
+----TRVMIVDDHPMWREGVARDLGSRGYDVCATASDVAGAIGIALATRPDVVVMDLQLGDGSGVDATREITAALPDTRVLVLSASAEQSDVLAAVKNGASGYLVKSASLDEFDDAVRRTAE----
+----TRVMIIEDEPVIALDLRAIVENAGHSVTGVARTRDQAVALAQKSPPGLVLADIQLADSSGIDAVKDILDE-MNVPVIFITAYP--ERLLTGEKPEPTYLVTKPFMPETVSATISQAL-----
+----TRVMIIEDDLNIAQLHQRYLEQEGYEVIGIATTKVEAEIQLDVLNPDLLLLDVYLPDGTGLELLQELRARNQSCDVILITAARDVDTLQQAMRGGVVDYLLKPVVFPRLEAALKKYVVQ---
+----TRVMIIEDDLKIAELHRRYLEQIGFEVVGMATSKAEAEIQLEILEPELVMLDVYLPDGTGIEILAWLRSLNQECDVILITAARDVETLQQAMRGGVIDYLLKPVMFPRLEAALKKYQKRT--
+----TRVMIIEDDLAIAQLHQRYLEQVGYEVIGIATTKLEAKLQLEVLSPDLLLLDVYLPDGTGIEILHELRTEHLSCDVILITAARDVETLQQAMRGGVVDYLLKPVVFPRLEAALKKYVLQ---
+----TRVMIIEDDLAIAQLHQRYLEQIGYEVIGIATTKLEAGLQLEVLAPDLLLLDVYLPDGTGLDILHELRSNNLSCDVILITAARDVETLQQAMRGGVVDYLLKPVIFPRLEAALKKYTSQK--
+----TRVMIADDHAVVRDGLRHILERAGFEVVGEAADGTQVPRMVRECTPQVLLLDLSMPGRSGLELIRLLRGEHPALRILVLTMHAEEQYIVRAFQAGAAGYLTKESAATELVSAIGQVAR----
+----TRVLYIEDNHDNQRLVRRVLATRGYQ-IIIANDGNEGWKSAQTDRPDLILMDINLPGLNGYELTTKFKAQLASVPIVALTANTTPGDRERALAAGCDGYISKPIDPRALPDLVASY------
+----TRVLYIDDEKTLLTLTQIYLREANLD-VEIAASAEEGLVLLRNESFDAIISDYDMPDMDGIELLKCVRKENPTIPFIVFTGKGREEIVIEALNYGADFYLQKGGDPKELANAIRHLVRR---
+----TRVLYIDDDDALARLVQKKLGRLGFV-VEHASSPEQALTRLEEGGFDVLALDHYLGAGTGLEFLARLATRGAAPPAVYVTGSSEMSVAVAALKAGASDFVPKTIGD-DFIALLASALD----
+----TRVLVVEDSEEDAEAIERALTRTHPARLEFTAHGDGLAERLDEELPGMILLDLNMPGADGHKVLAALRAELAGLTVVVFTSSTAPAEVDACYAAGADSYIYKPVNFDLFRTVLKGAV-----
+----TRVLVVEDNRLNQEVLQGLLQRVGVQ-VVLAANGAQALRLLEEGRFDAVLMDCQMPVMDGFATTRKIRGHLRWLPIIAVTASSQADVQGRAVAAGMSDLLSKPLEVAAFYRTLVRWIKAT--
+----TRVLVVEDNRLNQEVLQGLLQRVGGQ-VVLAANGAQALRLLEEGRFDAVLMDCQMPVMDGFATTRKIRGHLRWLPIIAVTASSQADVQGRAVAAGMSDLLSKPLEVAAFYRTLVRWIKAT--
+----TRVLVVEDHFPDAVLLEEWLELAEVQEVVHVVTFAEATSRWPDGRFDALLLDLDIPDGFGLDLVERGLALAGAVPVVVLSGRADEAVAAGAVGLGARAYVVKPASVHELRAALE--------
+----TRVLVVEDESSYSEALSYVLRKEGFD-VAIAETGPDALLEFDRAGADIVLLDLMLPGLSGTEVCRQLRQT-SSVPIIMVSAKDTEVDKVVGLELGADDYVTKPYSPRELVARIRAVLRR---
+----TRVLVVEDEESYSDALSYVLRKEGFE-VAVAETGPDALDEYDRAGADIVLLDLMLPGLSGTEVCRALRTR-GNVPVIIVSAKDTEVDKVVGLELGADDYVTKPYSPRELLARIKAVLRR---
+----TRVLVVEDEESYSDALSYMLRKEGFE-VAVAPTGTVALETFDRTGADLVLLDLMLPGLSGTEVCRTLRQK-SNVPVIMLTAKDSEIDKVVGLELGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESYSDALSYLLRKEGFE-VAVAPTGTSALEIFDRTGADLVLLDLMLPGLSGTEVCRTLRQK-SNVPVIMLTAKDSEIDKVVGLELGADDYVTKPFSSRELVARIRAVLRRR--
+----TRVLVVEDEESYSDALAYMLRKEGYE-VAIAANGNDALTEFDRNGADIVLLDLMLPGLPGTEVCRQIRQT-SSVPVIMVSAKDDEVDKVVGLELGADDYVTKPYSPRELVARIRAVLRR---
+----TRVLVVEDEESFSDALSYNLRKEGFE-VAVASTGPDALEIFDRNGADLVLLDLMLPGLPGTEVCRELRAR-SNVPVIMLTAKDSEVDKVVGLELGADDYVTKPFSTRELIARMRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAVATTGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAVAATGPEGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAVAATGPEALDTFDRNGADLVLLDLMLPGLPGTEVCRSLRQR-SNVPVIMLTAKDSEIDKVVGLELGADDYVTKPFSSRELVARIRAVLRRQG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAVAATGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAVAATGPDALEQFERNGADLVLLDLMLPGLPGTEVCRQLRVR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPYSTRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAVAATGNEALKEYEKAGADIVLLDLMLPEKSGTEVCRELRTT-SNVPIIMVTARDSEVDKVVGLEIGADDYITKPYSPRELVARIRAVLRRN--
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAVAASGPEALEVFDREGADLVLLDLMLPGLPGTEVCRSLRQR-SKVPVIMLTAKDSEIDKIVGLELGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAIATTGPEGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAIATTGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAIAATGPEGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAIAATGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRVR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAIAATGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRSR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFE-VAIAATGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEESFSDALSYMLRKEGFD-AVVANNGPEALAEFERGGADVVLLDLMLPGLPGTEVCRQLRSR-SSVPIIMLTAKDAEVDKVVGLELGADDYVTKPYSARELVARIRAVLRRRG-
+----TRVLVVEDEEFFSDALSYMLRKEGFE-VAIAATGPDGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRSR-SNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRG-
+----TRVLVVEDEDSISDPLSYMLRNEGFE-VAVADTGPAALEEFDRHGADLVLLDLMLPGLPGTEVCRQIRAK-SNVPVIMLTAKDSEIDKVVGLELGADDYVTKPFSARELVARIRAVLRRQA-
+----TRVLVVEDEASYSEALSYMLRKEGFE-VAVAEDGTDALKEFDRNGADIVLLDLMLPGLSGTEVCRQIRAT-SSVPVIMVTAKDDEVDKVVGLELGADDYVTKPYSPRELVARIRAVLRR---
+----TRVLVVEDDPQLVRALVLNMRARHYG-VEAAPDGATALRLAVAGRPDVVLLDLGLPDMDGVDVIKALRG-WTRVLILVLSARQAS-------------------------------------
+----TRVLVVEDDPQLVRALVINLQARHYD-VDAAPDGTTALRLAASHQPDVVVLDLGLPDMDGVDVIKALRG-WTPVPVLVLSARRASEEKVAALDAGADDYMTKPFSMDELLARLRASVRRT--
+----TRVLVVEDDPQLVRALKINLQARKFE-VLEAGDGAMALRLAAARTPDAILLDLGLPDMDGVEVIRGVRG-WSHVPILVLSARHTSEEKIRALDAGADDYVTKPFSMDELLARLRAATRRQ--
+----TRVLVVEDDPQLVRALKINLQARKFE-VEEASDGGSALRLAASHKPDVIVLDLGLPDMDGIEVIKGVRV-WSKVPILVLSARHTSEDKIRALDAGADDYVTKPFSMDELLARLRAAARRHE-
+----TRVLVVEDDDVIRELIRLNLELEGFE-VFTAVDGQDCLDRAAHIDPHVVTMDVMMPRVDGWTAVERLRARTRDRPIIMVTARTQETDHQRGRRVGMDAYLTKPFDPDVLIDIIRSLVDR---
+----TRVLVVDNDADALAAMQQLLLSWGCD-V-IAVRGAEGIDAS-AHDAALWLFDYHLDGDTGVALFTRLAAAQGPRPTVILSADTGAETREAVRGAGL-SLLSKPFRPLALRWAINHLLASA--
+----TRVLVVDDSRTFRKALRLIFSRSDIAVVGEAESAEEALSLLGALSPDVVTLDIEMPGMGGLLLAERIRTD-FSARILVVSGQTHSRTAVEALLKGAHDILEKPADME---------------
+----TRVLVVDDSRFMRTVIGNALTEAGYE-VETATNGVEAVDTAAEFDPAVVTMDVEMPEMNGIEAVERIMAQ-NPTLILMLSAYTDEDATLDALERGAIEFLPKP-------------------
+----TRVLVVDDSGFMRTVIGNALTEAGYE-VETATNGSEAIEAVAAYDPDVVTMDVEMPKLGGIDAVERIMAT-NPTLILMLSVHTEEEATLDALERGAVDFLHKP-------------------
+----TRVLVVDDSAFVRLAVTEILREAGIEVVGTAKNGKEAVEKTLELEPDVVILDVKMPVMDGLTALKHIMEK-KPTPVLMFSSYTKEDAKEEALKLGAVDFVPKP-------------------
+----TRVLVVDDQTVVRDGLVLILGLLDIEVVGAAADGAEALRLVDEHHPDVVLMDLRMPRMDGAEATGRIKAAHPEVQIVVLTTYSDDESVFAALKAGARGYLTKDAGGEEIAAAIAAV------
+----TRVLVVDDNVANQAVARAVLEAAGVL-VGTANDGRQALARLRVEDFDLVLMDVHMPVMDGIEALRRVRGGRADVPVMALTADAMSGEAERLVGLGFDDAQPKPIQPAGLLRAIAR-------
+----TRVLVVDDHRIFAESLAAALAAEDVD-VGAAGSGPAALRSLERRPFDVVLVDADLGVLDGISLVGGLRATQPGVRTVVLAERDDPRRAALALQAGASGWVAKDCSLSRLLTVVRGVLRDE--
+----TRVLVVDDHPVVRGGLVGWLDQPDLTVVGEASDGLEALAMVASLDPDVVLMDLRMPRMDGVAAIERLAGTHPGVRVLVLTTYDTDADIVRAVAAGATGYLLKDAPLPQLADAVRAAAR----
+----TRVLVVDDHPVLRDGVRAALVAASLDIVGEAASAADAVRLAVELRPDVVLLDLQLPDFSGIEAARRIARDAPDAAVLAFTMSDDDETVFAALRAGAIGYVVKGVESRELVHAIETVAH----
+----TRVLVVDDHLLSRKGIASILSAHPFEIAGEATNGQEAVEQARRLVPDLILMDIRMPNGSGLEATRRLKEEMPYVKIIILSVSDDVQDFFEAIKYGAQGYLLKNMEPEYWLDYIMSIVQ----
+----TRVLVVDDHEVVRRGLMTLIDEETMETVGEASCGQDGIDLAVSLAPDVVLMDVQLPDVDGITAARTIIES-TSCKVVMLTALADEEVVYGGLRAGVSGFLLKVAPSHELIEAVSLA------
+----TRVLVVDDEPQLLRALRINLTARGYE-VLTAVDGKAALRAAGDGKPDAVVLDLGLPDMDGSEVIAGLRG-WTTVPIIVLSARTDSTDKVHALDAGADDYVTKPFGMDELLARLRAAVRRAN-
+----TRVLVVDDEPQIVRALVINLRARHYE-VDAAADGAAALQLAAARHPDVVVLDLGLPDMDGVEVIRGLRG-WTRVPILVLSARHSSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARRYE-VDAAPDGATALQLAAARHPDVVVLDLGLPDMDGVEVIRGLRG-WTRVPILVLSARHTSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARQYE-VDAAPDGATALQLAAARHPDVVLLDLGLPDMDGVEVIRGLRG-WTRVPILVLSARQTSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARQYE-VDAAPDGATALQLAAARHPDVVLLDLGLPDMDGVEVIRGLRG-WTRVPILVLSARHTSDEKVEALDAGADDYVTKPFGMDELLARLRASVRRA--
+----TRVLVVDDEPQIVRALVINLKARKYE-VDSAHDGASALELAAARHPDVVVLDLGLPDMDGVEVIRGLRG-WTRVPIIVLSARHASDEKVEALDAGADDYVTKPFGMDELLARMRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARKYE-VDAASDGAGALELAAARHPDVVVLDLGLPDMDGVEVIKGLRG-WTRVPILVLSARHSSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARKYE-VDAAPDGATALRLAAERHPDVVVLDLGLPDMDGVEVIKGLRG-WTRVPILVLSARQTSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARKYE-VDAAPDGATALQLAAARHPDVVVLDLGLPDMDGVEVIKGLRG-WTRVPILVLSARHTSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARKYE-VDAAHDGATALKLAAARQPDVVVLDLGLPDMDGVDVIRGLRG-WTRVPILVLSARHSSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARKYE-VDAAGDGRTALDLAASRHPDVIVLDLGLPDMDGVEVIRGLRG-WTRVPILVLSARHSSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARKYE-VDAAADGAGALELAAARHPDVVVLDLGLPDMDGVEVIRGLRG-WTRVPILVLSARHSSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALVINLKARAYE-VDAAHDGATALALAAARHPDVVILDLGLPDMDGVEVIDGLRG-WTRVPIIVLSARHTSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPQIVRALQINLKARRYE-VHVAGTGTAALQVAAQHPPDLVILDLGLPDLDGIEVIRGLRG-WTEAPILVLSGRTDSTDKVEALDAGADDYVTKPFGIDELLARMRAALRRS--
+----TRVLVVDDEPQIVRALELNLRARQYE-VDSAGDGTTALRLAAERHPDVIVLDLGLPDMDGVDVLRGLRS-WSRVPVLVLSARQSSDEKVQALDAGADDYVTKPFGMDELLARLRAAVRRT--
+----TRVLVVDDEPQILRAMRINLSARGYE-VVTASSGAGALRAAAETQPEVVILDLGLPDMDGTEVLAGLRG-WTDVPVIVLSARTDSADKVEALDAGADDYVTKPFGMDEFLARLRAAVRR---
+----TRVLVVDDEPQILRALRINLTARGFD-VTTASTGAGALRAAAERQPEVVVLDLGLPDMDGFEVLAGLRG-WTNVPVIVLSARTDSSEKVDALDAGADDYVTKPFGMDELLARLRAAVRR---
+----TRVLVVDDEPQILRALRINLSVRGYE-VTTASTGAAALRAAAERHPEVIVLDLGLPDMDGIEVLAGLRG-WCTAPVIVLSARTDSSDKVEALDAGADDYVTKPFGMDEFLARLRAAVRR---
+----TRVLVVDDEPQILRALRINLSVRGYD-VVTAASGAAALRAAAERPPDVIVLDLGLPDMDGTEVLAGLRG-WCPAPVIVLSARTDSADKVEALDAGADDYVTKPFGMDEFLARVRAAARRAT-
+----TRVLVVDDEPQILRALRINLLARHYE-VAVAADGGAALREAADWRPDLVILDLGLPDIDGVDVIHGLRG-WTSIPIVVLSGRAGGADKVDALDAGADDYVTKPFNIDELLARIRAVTRRTA-
+----TRVLVVDDEPQILRALRINLLARHFE-VAVAPDGGSALRQAADWHPDLVVLDLGLPDIDGVDVIHGLRG-WTAVPIIVLSGRAGNQDKVEALDAGADDYVTKPFNIEELLARMRAVTRRTA-
+----TRVLVVDDEPQILRALKINLSVRGYE-VVTAATGAGALRAAAEHRPDVVILDLGLPDISGIEVLAGLRG-WLTVPVIVLSARTDSADKVEALDAGADDYVTKPFGMDEFLARLRAAARRN--
+----TRVLVVDDEPQILRALKINLSVRGYE-VTTAATGAEALRSAADHKPDVIVLDLGLPDMSGIEVLAGLRG-WLSAPVIVLSARTDSSDKVEALDAGADDYVTKPFGMDEFLARLRAAVRRAT-
+----TRVLVVDDEPGIVRALVINLRARAYE-VDAAHDGATALRLAAAHRPDVIVLDLGLPDMDGVEVIRGLRGR-TRVPILVLSARHASDEKVGALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDEPAVRSFMGQSLRLAGYD-AWEFDGPAAAVEALDREDVALVVTDVQMRGSSGPTFARRLRLTHPSLPVLFVSGFAPEELDLEGGARRA--FLAKPFGRATLLDAVATLIAEA--
+----TRVLVVDDEPALVRALVINLKARSYE-VDAAHDGAGALELAAARHPDVVVLDLGLPDMDGVEVIKGLRG-WSRVPILVLSARHASAEKVQALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVVDDDRAVRESLRRSLSFNGYS-VSLATDGVEALEAISNERPDAMILDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTT-
+----TRVLVVDDDPTVSNVVSAYLTKAGYD-ARVVPDGVKAVEVWQQWKPSVVVLDVMLPGLSGLEVLRRLRSADDGAAVIMLSARGEEEDRLVGLEVGADDYVVKPFSPRELVLRVQALLRRE--
+----TRVLVVDDDPTVAEVVDRYLRNAGFD-VDRAADGLTALRMAETTVPDLVVLDLMLPGIDGIEVCRRLREQ-RPVPVIMLTARGEEADRVAGLETGADDYVTKPFSPRELTLRVRSVLRRA--
+----TRVLVVDDDPHIRELVGHFLRLEGLE-VVEAVDGLDAMRLFDETKVDLLVLDIMMPGMDGWELCRKLREQ-TDLPLLMLTAKGETSQIVKGFALGTDDYLVKPFDPMVLVARVKALLKRY--
+----TRVLVVDDDITARLMARQALGKENFA-VIEAEDGFAALALFEAVQPDIVLLDVEMPGMNGFEVCRQLRRCGKLVPILMATGQDDLDSVRQAYEAGATDFVTKPFNWKILAHRLRYMVRAS--
+----TRVLVVDDDAGVRFTLREMLKSLGVE-VDEAVDGEDALEKLSARPYELVISDLRMPRMDGMELVRRLSLFSRSPRVIVITAHGSERFAVEAMKAGAYDYFRKPFDVDELLAVVSRALESV--
+----TRVLVVDDDADFGDMILAMLEHRGVE-AAVVSSPLDALEVLRDHPWDVMVTDQTMPGMRGIDLVKAVKAIRPDLPCLICTGYPEALDEAALTKAGVFALLHKPVDFPHYFAQLARAL-----
+----TRVLVVDDDADACGFLTRALGGEAML-VHTAANGNAALDALTSFAPDAVLLDVDMPGMDGFAACTALLDRHADLPVIFMTGLGDTGHIVRGFEVGACDYVTKPVAIAEVVARVRSHAG----
+----TRVLVVDDAKFMRVKIRESLEEANYIIAGEAADGEQAADLYKKLRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIVKPFEETKVLEAVSRVM-----
+----TRVLVVDDAKFMRVKIREILESANYTVAGEAADGEEALAVYQKIRPDLVTMDITMPVKNGIQALQDILAFDPKARIIMCTAMRQQRIVLEAIELGAKDFIVKPFEASKVLEAVGRV------
+----TRVLVVDDAKFMRVKIREILESANYIVAGEAADGEEALAVYQKIRPDLVTMDITMPVKNGIQALQDILAFDPKAHVIMCTAMRQQRIVLEAIELGAKDFIVKPFEASKVLEAVGRV------
+----TRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKKLRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIVKPFEETKVLEAVSRVM-----
+----TRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKKLRPDIVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIVKPFEETKVLEAVRRVM-----
+----TRVLVVDDAKFMRVKIREILEAANYIVAGEAADGEEAADLYQRLRPDLVTMDVTMPLKNGIQALQEIMSFDPKANVIMCTAMRQQRIVVEAIELGAKDFIMKPFEESKVLEAVNRVM-----
+----TRVLVVDDAAFMRMMVKDILSKNGYEIVGEAENGMKALEKYQELKPDLVTMDITMPEMDGITAVKEIKKVDPAAKVVMCSAMGQQAMVIEAIQAGARDFIVKPFQADRVLEAIRKAV-----
+----TRVLVMDDDRIQQGITREMLSRSRIH-CDCCTDVRELMDCLKSQEYDLLLTDIQMPGADGFSILELLRGRAREIPAIAVTAHSD--REEEYLFAGFAGCIHKPFSAEGLVTAIMRVIKG---
+----TRVLVIEDEPQIVRALVINLKARKYE-VDTAHDGAGALRLAAARHPDVVVLDLGLPDMDGVEVIRGLRG-WTRVPILVLSARHSSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVIDDEPQIVRALVINLKARHYE-VDAAHDGATALQLAAARHPDVVVLDLGLPDMDGVEVIRGLRG-WTRVPILVLSARHSSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRA--
+----TRVLVIDDEPQILRALRINLSVRGYE-VVTASTGAGALRAAAEHKPDVVILDLGLPDISGIDVLAGLRG-WLTAPVIVLSARTDSSDKVEALDAGADDYVTKPFGMDEFLARLRAAVRRN--
+----TRVLVIDDEPQILRALRINLSVRGYE-VVTASSGAGALRAAAEHKPDVVILDLGLPDISGIDVLAGLRG-WLTAPVIVLSARTDSSDKVEALDAGADDYVTKPFGMDEFLARLRAAVRRN--
+----TRVLVIDDEPQILRALRINLSVRGYE-VITASSGAGALRAAAEHKPDVVVLDLGLPDISGIDVLAGLRG-WLTAPVIVLSARTDSSDKVEALDAGADDYVTKPFGMDEFLARLRAAVRRN--
+----TRVLVIDDEPQILRALRINFSVRGYD-VVTAATGAAALRAAAEQRPDVVILDLGLPDMSGIEVLAGLRG-WFSAPVIVLSARSDSSDKVQALDAGADDYVTKPFGMDELLARLRAAVRRAA-
+----TRVLVIDDEPHILRALRINLTVRGYE-VITASTGAGALRAAAEHPPDVVILDLGLPDISGIDVLAGLRG-WLTAPVIVLSARTDSSDKVEALDAGADDYVTKPFGMDEFLARLRAAVRRNA-
+----TRVLVASANAAFADFLCATLQEAALR-AEAACSGVAVEQALARDPFAFLLMDADLPEPGGFALAQRFAAARPDRIIPMMASHSQRNDALRCEELGLGYRLAKPFSAEDLLAVLRM-------
+----TRVLVAEDEALIRLDLVEMLGEQGYEVVGQASNGQQAVELAKELRPDVVIMDVKMPVLDGLSAAEQLHEA-KLCPVIMLTAFSQTELVERARDAGVMAYIVKPFTADDLRPAIDI-------
+----TRVLVADDQDLVRTGLSMILDQPDIEVVGQAADGKAAVELAHRLRPDVCLVDIRMPGLDGIEVTELLAGRADPIAVVVITTFDLDEYVHGALRAGARGFLLKDAGPALLVQAVHAA------
+----TRVLVADDQAMVRGSFRVLVDTPGLSAVGEAADGAEAVELARRERPDVVLMDIRMPGLDGIGATRRICAATAGVRVLILTTFDLDEYVYAALRAGAAGFLLKDTPPSRVLDAITVV------
+----TRVLVADDNFTSRAILKEVLESLRFD-VTLAESGEEAVDLVQKEPFKVVLLDWRMPGLDGLACARHIRQLDLPVRILIITAYGREEVLGEIPSEIIDGVLLKPVARSLLLNTILDALP----
+----TRVLVADDHPEALEILVYMLTQLQCS-VTAVSGGLEAVGAVSMTPFELVLMDWEMPKTNGLDAAQLILSETAPPKLILISGTH-LKNSEILKKYGFIGFIAKPITPVSLKTSLEEILNQH--
+----TRVLVADDHALVRDGLRHILKASGFEVVGEASDSASTVALIRTCAADVLVLDLSMPGRNGVELIKQIKDEKPALRILVLTMHAEQQYAVRAFKAGASGYLTKESASAELVSAVAKVA-----
+----TRVLVADAHPLLLRGVQHLLREPDLSIIGEAISGAQALRLASDLQPDIAILDVALPGLHGSEIRQRLAERAAGTRVIILSGTEEPICAQRALAAGVCGYVLKRSAPETLLHAIRAV------
+----TRVLLVRDEQVNLELIRAGLAEAGFVDVGVVDADLMLPERIAQTQPDMVIVASESAARDTIEHVCVATQH-APRPIVLFTDNDDASRIKAAFAAGITAYIVDGLKPTRVKAVLDVAYAR---
+----TRVLLVRDELVNLELIRAGLAEAGFVDVGVVDADLMLPERIAQTQPDMVIVASESAARDTIEHVCVATQH-APRPIVLFTDNDDASRIKAAFAAGITAYIVDGLKPTRVKAVLDVAYAR---
+----TRVLLVEDNELNRDMLSRRLKRSGFE-VLFAEDGQQAVDTAAAEMPDLILMDLSLPTMDGFEATRALRAKTAGLRVIALTSHAMSGDRERALAAGCDDYDTKPVDLPRLLGKMHALLD----
+----TRVLLVEDESLVAMLLEDCLTELGYEVAATVGDVDTALEVVQQGNLDLAVLDVNLGGVLSFPIAEELDTR--GVPYIFVTGYAQGGIPEKFRHRH---GLQKPFQFRDLKEALSVLER----
+----TRVLLVEDDQRIRQALGLALADIGFE-VVEADSGDQALDRLDHLVVDVVLLDLMLPGVDNLTVCRIPRS-CGDLPIIIDSARTDTEGVIEGLESGADD------------------------
+----TRVLLVEDDPAISEPLARALGREGYE-VLASSTGREALTNVE--GADLVVLDLGLPDMDGLDVAREIRADGGRVPILILTARTDEVDMVVGLDAGADDYVTKPFRLAELLARVRALLRRHT-
+----TRVLLVEDDPAIAEPLTRALQREGYE-VGAHVTGGSALKQVN--DSDMVILDLGLPDMDGLDVARTIRAQGITIPILILTARTGEVDMVVGLDAGADDYVTKPFRLGELLARVRALLRRSG-
+----TRVLLVDDSPVDRRVVQLLLSSSSFH-VIAVDSAKKAMEFLKEQAIDMVLTDYCMPEMTGYELLKAIKALLKPIPVIVMSSENEPQRISRCMNAGAEDFIVKPLQSKDVQR-----------
+----TRVLLVDDSPVDRRVVQLLLSSSSFH-VIAVDSAKKAMEFLKEQAIDMVLTDYCMPEMTGYELLKAIKALLKPIPVIVMSSENEPQRIS---------------------------------
+----TRVLLVDDSPVDRRVVQLLLSSSSFH-VIAVDSAKKALGFLKEQAIDMVLTDYCMPEMTGYELLKAIKALLKPIPVIVMSSENEPQRISRCMNAGAEDFIVKPLQSKDVQR-----------
+----TRVLLVDDQAVVRAGYAVILASEGLDVVGDAASGREAVQRARELRPDVVVMDVRMPGGDGITATRELAGAVDPVPVLVVSTFDLDEYVFGALEAGAGGFLLKDAEPEVLAAAVRRVAA----
+----TRVLLVDDNYTVREVLARRLQSFGID-AVMASNGPEGLDYLVANAYDLLFVDSDMPDITGVDFLSKAQQKLPSRVAVMFSAGCTEEERQNARLVGADYTLIKPVFDADLIRCLASV------
+----TRVLLVDDNPINRAVATEMLHAAGVE-VEAVPSGETALDTLANVAFDAVLLDIQMPGMDGYQTAAAIRARRPGAPVIAFTARVEGEDEEALHRAGIVGRLPKPVDRQELLATLHRHL-----
+----TRVLLVDDHPVVRRGVRATIEDETITVAGEAGSGEQALALLAELAVDVVLLDLQLGGIDGAETTRRIQRLPRPPRVLVLTTYDTDADILPAIEAGATGYLLKDTDPAELIAAIHAAA-----
+----TRVLLVDDHPVVRAGLRAVLESLGITVCAEAQDGRAALERLGTHGVDVVVMDLQMGGMGGLEATRRIVAS-GGPPVLILTTYDTQADVVAALEAGATGYLLKDAQPETIGQAVHDAA-----
+----TRVLLVDDEPELLEAWSFALEYVGYD-VERARDGRQALAAIERQPPDLLITDLMMPGMNGEDLCRALRSRWAEIPILLHTSAYIGANDGAAL---WNAVLRKPARIEDFLATVAKLT-----
+----TRVLLVDDELLAREILRDYLSDSSIEVVGEASDGRVAVVQAASLRPDVILMDMQMPVMDGVAATAQIHAEFPDIAILGLSTFSTDRYVVDLLRAGASGYLVKDTLPKEITAAIHTVMA----
+----TRVLLVDDEKNVLSALRRALFDDPYE-IMTASSAEEALEIMKLHSFKVVISDERMTGMQGVDFLARVRVLSPETVRILLTGHGTMEAAMKAVNLGIYRFFTKPWNDLEIRFAVRSAVEKY--
+----TRVLLVDDDRELTEMLSQYLTRESFT-VTCTNSAEEGENEALSGRHDIVVLDIMMPRMSGIEVLRRIRAQ-SQVPVILLTARGDNIDRISGLELGADDYVPKPSSPGELVARLRAIMRRV--
+----TRVLLVDDDRELTEMLSQYLTRESFT-VTCTNSAEEGEIEALSGRHDIVVLDIMMPRMSGIEVLRRIRAQ-SQVPVILLTARGDNIDRISGLELGADDYVPKPSSPGELVARLRAIMRRV--
+----TRVLLVDDDQTILSLLKRGLAYEGFE-VYTAPDGETGLAATKKYQPHLVLLDIAMPGLDGLELCRRLHVL-GDIAIIMLTARDDVADKVHALGLGADDYVPKPFSFDELVARMRAVLRRHT-
+----TRVLLVDDDPLVRAGLRLMLESAGLDVVGEVGDGAEVVDAVARWAPDVVLMDIRMPVLDGIAATRALVDRPGATPVLVLTTFGADRTVVDALRAGAAGYVLKDTPPAEIVEAVRRVAA----
+----TRVLLVDDDPLVCGALATMLGSADLNVVGSVNDGDQVVEAIHRHRPDIILMDVRMARQDGITTTASLSGLETPPKVIMLTTFDHDDVMLRAVHAGAAGFLLKTASPLDIIAAVQSVAA----
+----TRVLLVDDDAELTGMLVQYLGHEGFA-AEVAHDGEAGVARALSGDFAIVVLDVMMPRLSGIDALRRIRAA-SQVPVVMLTARGDNIDRISGLDLGADDYVPKPCTPGELVARLRAILRRT--
+----TRVLLVDDDAELTGMLVQYLAHEGFA-AEVAHDGEAGVARALSGDFAIVVLDVMMPRLSGIDALRRIRAA-SQVPVVMLTARGDNIDRISGLDLGADDYVPKPCTPGELVARLRAILRRT--
+----TRVLLIEDNVDLAKTIIQFLTLEGFD-TDYVGNGHAGFNFAVKNKYDVFILDINLPGLDGLSVCQKLRSQGIDAPILMLTARGTLFDKLAGFDAGTDDYLIKPFALDELLARLRALAKRK--
+----TRVLLIEDEPLIAMDTESHLVSAGCEVVGLAATIEEARQLIADKVFDIALVDANLSGEPVDEIAVALAR--KGIPFAFATGYGAEALPPAFRDAP---ILTKPFSPQALLAEVAALRAR---
+----TRVLLIEDDRDLAETLLQLMEFENMV-PDYASNGVAGLTLAQSNRYDILVIDIGLPKMNGLTLCEQLRQEGCQTPILFLTARGSIDDKLAGFASGGDDYLSKPFDNRELLARIMVLS-----
+----TRVLLIEDDPAVRRGVTLGLRRRGHE-TEAVATGEDGLEALAASPPDLVLLDLMLPGMSGLEVCRRIRET-SQVPVVILSARGDDIDVVVGLEAGADDYIVKPSSDEVIEARMRAVMRRL--
+----TRVLLIDDDTRMYELLEQYLGQNGLS-VTHAADGGRGLAALEASAFDAVLLDVMMPGMDGLEVCKRIRAK-SRIPVIMLTAKGDETDRVVGLELGADDYLPKPFSPRELLARLRAVLRRS--
+----TRVLLIDDDTRMYELLAQYLGQNGIS-VAHAPDGGRGLAALEGSPYDAVLLDVMMPGMDGLEVCKRIRAK-TQVPILMLTARGDETDRVVGLELGADDYLAKPFSPRELLARLRAVLRRA--
+----TRVLLIDDDLEFTGLLCEYLTDEGFD-VLSTDDGAKGLAFVDSGATDIIVLDVMMPIMNGVDVLQNIRKS-SEIPIVMLTARGDDKDRITGLDLGADDYVSKPCSPGELVARLRAILRRTG-
+----TRVLLIDDDARLTHMVRDYLQAAGHV-VSVAGDLAGGRGLLQRESFDALILDLMLPDGDGLDLTRELRARWRSLPLLMLTARGEPLDRIVGLELGADDYLPKPFEPRELLARLKALLRRAS-
+----TRVLLAEDNDLNAEIAVALLDMQGVE-ARRAANGREAVDMFEASEFDFVLMDVKMPLLDGLEAAIEIRSDARTVPIIALTANTFQEDREDAAAAGMDGFIPKPFDAQQLYETLRSYLPRK--
+----TRVLLAEDNDLNAEIAVALLDMQGVE-ARRAANGREAVDMFDASEFDFVLMDVKMPLLDGLEAAIEIRADARTVPIIALTANTFQEDREDAAAAGMDGFIPKPFDAQQLYETLRSYLPRK--
+----TRVLLAEDNATNQIVGAMILRNLGCL-VDVATNGREAMEMVDAFLYDMVFMDCEMPEMDGFEATAALRRRKSRLPVIAVTAQAMQGDRERCLRAGMDDYISKPVKLEDFAAALKRWM-----
+----TRVLLAEDNAALAQMLQTFLAAQGME-TIIAGTGTEAMRVLASSPVDLLLLDLKLPELSGVEVLQRLRKELASLPVIIMTGYRGEKYALGAQKLGVRHYLEKPFSRQAFLNAVHSSLT----
+----TRVLLAEDDPAISEPLARALRREGYE-VEVRADGREALEAARE-NPDLVVLDLGLPTMDGLEVCRRLRGEGHTVPVLVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARARALLRR---
+----TRVLLAEDDPAISEPLARALRREGYD-VDVREDGAEALEGAK-DNPDLVLLDLGLPKVDGLEVCRRLRAEGRSIPVLILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRT--
+----TRVLLAEDDEAIASPLARALTREGYD-VTVAATGTDAVRRALDEEFALLILDLGLPELDGLEVCREVRAARPEVAVLMLTARTDEMDFVVGLDAGADDYVGKPFRMFELMARTRALLRRS--
+----TRVLLAEDDASISEPLARALRREGYE-VEVRQDGPTALDAGLRGGVDLVVLDLGLPGMDGLEVARRLRSDGHTVPILILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVRQDGPTALDAGLQGGIDLVVLDLGLPGMDGLEVARRLRAGGHTIPILVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRR---
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTAVDAGLQGGIDLVVLDLGLPGMDGLEVARRLRSEGHAVPILILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGMQGGVDLVVLDLGLPGMDGLEVARRLRSEGHTVPILILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRR---
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGMQGGVDLVVLDLGLPGMDGLEVARRLRAEGHTIPILILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGMQGGIDLVVLDLGLPGMDGLEVARRLRAEGHTVPILILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGMQGGIDLVVLDLGLPGMDGLEVARRLRAEGHAVPILILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGLQGGVDLVVLDLGLPGMDGLEVARRLRGEGLAVPILVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRR---
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGLQGGVDLVVLDLGLPGMDGLEVARRLRAEGHTVPILVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGLQGGVDLVVLDLGLPGMDGLEVARRLRAEGHGFPILVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRR---
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGLQGGVDLVVLDLGLPGMDGLEVARRLRADGHAVPILVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGLQGGVDLLVLDLGLPGMDGLEVCRRLRTEGHGFPVLVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPTALDAGLAGGVDLVVLDLGLPGMDGLEVARRLRAEGHTIPILVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPGALEAGMQGGVDLVVLDLGLPGMDGLEVARRLRAEGHTVPLLILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRG--
+----TRVLLAEDDASISEPLARALRREGYE-VEVREDGPAALEAGMRGGIDLVVLDLGLPGMDGLEVARRLRSEGHTVPLLILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRR---
+----TRVLLAEDDAAISEPLARALRREGYE-VTVRADGPGALLA-GQSGVDLVVLDLGLPGMDGLEVCRRLRADGHTFPVLVLTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRR---
+----TRVLLADDQPLIRAGYRMILDSEDLEVVGEAVNGREAVFLARTTRADVVLMDIRMPEVDGIEATRRIAADLAGVRILVLTTFEEDENVLRAVRAGAAGFLGKNVGPAELLHAVRTVA-----
+----TRVLLADDQPLIRAGFRVLLDEDDIDVVGEASTGAEAVDLARETVPDIALVDVQMPEMDGIEATRRIAAALSSVRVVILTNYALDEYIFDALRAGASGFLVKDTEPEELIRAVRTVA-----
+----TRVLLADDHALVRDGLRHILRASGFDVLGEASDSASTVALIRACAADVLVLDLSMPGRNGVELIKQIKDEKPSLRILVLTMHAEQQYAVRAFKAGASGYLTKESASAELVAAVTKVA-----
+----TRVLLADDHALVRDGLRHILKASGFEVVGEASDSVTTVALIRACPAEVLVLDLSMPGRNGVELIKQIKDEKPALRILVLTMHAEQQYAVRAFKAGASGYLTKESASAELVAAVTKVA-----
+----TRVLLADDHAAIRAGLRLLLEQGGIEVVGEAADGQAAITNARALRPDVVLMDVRMPGVDGIEATRVITRE-GLADVVALTTFDLDEYVLGMLRAGAVGFLLKTTGAAALVDAVQRVAA----
+----TRVLIVEDQSMPRTLFEMYVNSENYTLAGSISNADMTDYHCENSDVDLILMDICTSGANGLEAAERIKAKFPKIKIIIVTSMPEYSYLKRAKEAGVDSFWYKEVSPEPIIELMDRTMN----
+----TRVLIVEDEPDLADPLAYLLRREGYE-VEIAEDGALALSAFHDRGADIVLLDLMLPGMPGTEVCRQLRLS-SHVPIIMLTAKDSEVDIVVGLELGADDYVTKPYSTRELLARMRAVLRRR--
+----TRVLIVEDEESMAEPLAFLLRKEGFS-TEIATNGPDALETFDRVGADIVLLDLMLPGMSGTEVCKQLRGR-GAVPVIMVTAKDSEIDKVVGLELGADDYITKPYSTRELIARIRAVLRR---
+----TRVLIVEDEESLADPLAFLLRKEGFE-TVIAGDGPTALTEFDRTGADIVLLDLMLPGMGGNDVCKQLRAR-SSVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELTARIRAVLRR---
+----TRVLIVEDEESLADPLAFLLRKEGFE-TVIAGDGPAALTEFDRSGADIVLLDLMLPGMGGNDVCKQLRAR-SSVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELTARIRAVLRR---
+----TRVLIVEDEESFADPLAFMLRKEGFT-TAVAANGNDALSEFDRNGADIVLLDLMLPGMSGTDVCKALRSR-SAVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARVRAVLRRG--
+----TRVLIVEDEESFADPLAFLLRKEGFT-AAVAVTGQQALEEFDRNGADIVLLDLMLPGMSGTDVCKQLRQR-SAVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARVRAVLRRG--
+----TRVLIVEDEESFADPLAFLLRKEGFT-AAVATTGQSALEEFDRNGADIVLLDLMLPGMSGTDVCRSLRSR-SAVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRG--
+----TRVLIVEDEESFADPLAFLLRKEGFT-AAVATTGQEALEEFDRNGADIVLLDLMLPGMSGTDVCKQLRQR-SAVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARVRAVLRRG--
+----TRVLIVEDEESFADPLAFLLRKEGFT-AAVAGTGQAALEEFDRNGADIVLLDLMLPGMSGTDVCKQLRQR-SAVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARVRAVLRRG--
+----TRVLIVEDEESFADPLAFLLRKEGFT-AALAATGPEALEEFDRNGADIVLLDLMLPGMSGTDVCKQLRQR-SAVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRG--
+----TRVLIVEDEESFADPLAFLLRKEGFT-AAIATDGQQALEEFDRNGADIVLLDLMLPGMSGTDVCRELRQR-SSVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARVRAVLRRG--
+----TRVLIVEDEDSLADPLAFLLRKEGFE-VGVAGDGPSALESFESEGADIVLLDLMLPGMSGTDVCKRLRMT-SSVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRR---
+----TRVLIVEDDTIIAMTAEDMLDECGCKTAAIAVSVAEALARAADTDFDIALLDLNLKDENSLPVAQHLRDA--GKRFIFATGYDGLPAD-----SGFADVISKPYRIEQLATVIAQTL-----
+----TRVLIVEDDIDIRGILARGLEAEGFS-VGVAGRVEDALSAARDEAPEAVVLDITLPDGSGHDVCRSLREGGYPGAILFLSARDEVRDRAEGLALGADDYIVKPFVFDELLARLQVHLL----
+----TRVLIVEDDIDIRGILARGLEAEGFS-VGVAGRVEDALSAARDEAPEAVVLDITLPDGSGHDVCRSLREGGYPGAILFLSARDEVRDRAEGLALGADDYIIKPFVFDELLARLQVHLL----
+----TRVLIVEDDIDIRGILARGLEAEGFS-VGVAGRVEDALSAARDDAPEAVVLDITLPDGSGHDVCRSLREGGYPGAILFLSARDEVRDRAEGLALGADDYIVKPFVFDELLARLQVHLL----
+----TRVLIVEDDIDIRGILARGLEAEGFS-VGVAGRVEDALSAARDDAPEAVVLDITLPDGSGHDVCRSLREGGYPGAILFLSARDEVRDRAEGLALGADDYIVKPFVFDELLARLQTHLLR---
+----TRVLIVEDDEILGDELRDVFTQWGFE-ASLVASVHDFWANVEDYQPQLVVVDLTLPDGSGVDIIRDVRSK-SDIGIIVMSGRSDEIERVVCIETGADDYVVKPFSSREMVARIRQLMYRT--
+----TRVLIVEDDEDIASVIARGLQREGYE-TLCAADVRAARDAMVAEMPDAAIVDMMLGEESGSKLVADLRAKGVRIPIIMLSALSRVSDRTAGLVAGADDYVVKPFEFKELVARLK--------
+----TRVLIVEDDDRLRRTLAINLQARRHE-VHTAADGGTGLELAATIHPDLVILDLGLPDMDGVEMVSLLRRR-SAVPVIILSARDAEATKVAALDAGADDYVTKPFGMEELLARMRAAVRRA--
+----TRVLIVDDSHTMCALVQLELSDPELEVVAVAHNARDARDAIDQFKPDVLTLDIEMPGMDGLEFLSRVMKH-RPTPVVMVSSLTNKDLSVEALSRGAVDLFAKPG------------------
+----TRVLIVDDSEFMRSLLREILAE-DYEIVGEAENGVEAVELYEEHDPDLVMMDIVMPIRDGIEATTAITAGDADARVIMCTSVGQEEKMKMAVKAGASGYITKPFQKPSVLQAIDDVV-----
+----TRVLIVDDSALVRRILSEALSKHDIEVVGTATDPYVARERIAQLKPDVITLDIEMPRMDGLSFLSKLMRHF-PLPVVVCSSLTNSETALRALALGAVEVIAKPGSS----------------
+----TRVLIVDDQAMVRAGFAALLAQSDIDVVGEAPDGARGVELSRRTHPDVVLMDVRMPEMDGLEAARRLLTVTHVPRVLMLTTFDIDDYVYEALRAGASGFLLKDAPPADLIAAVRVVA-----
+----TRVLIVDDHPMVAEGIRSLLESYDLEIVGTLGNGQDAVDQAIALGPDVILMDLNMPGLSGLAATEMILEKQPDTRIVILSMHDSPEYISTALSHGARGYILKDVPTEEIHTAIETVM-----
+----TRVLIVDDEPQILRAMRINLRARGYE-VVVADTGATALTAAAETRPDIVILDLGLPDLDGVEVIHGLRG-WTRVPIVVLSGRADSRDKVGALDAGADDYITKPFGIDELLARLRAVARRTG-
+----TRVLIVDDDTQILRALRITLHARGYE-VMTATSGRHALAATTSGRPDIILLDLGLPDMDGAEVIHALRS-WTTTPVIVLSGRGGSTDKVGALDAGADDYVTKPFRVDELLARLRAVARRT--
+----TRVLIVDDDPTILEAFPVYLSTDDLKVVGTATTGRQALQWLETNSSDLVLSDIHMPDTDGIELLQHTQQLPQPPLFVAMTAFDTDETMLKCLSLGAVGYIIKGQAPESIIHSLRDAIH----
+----TRVLIVDDDPMVRRLLTAVLRGQGIDVVGEATDGDEVPAAVDAHRPDVVLMDLHMRRVGGLDAIRALRRRTDPPAVIALTSFGSDDTVVAALDAGAQGFLGKDDDPDRIANHVRQVAA----
+----TRVLIVDDDFMVARVHAGFVAALGFEVVGTASSGAAALAEVARLRPDLVLLDVYLPDMTGLEVLRRLRADAVPVDVVVISAARDVESIRSARHGGVLSYLVKPFDRQTFEARLREYA-----
+----TRVLIVDDAKFMRDKIREILETEDLQVAGEAENGEEAVLLYQELQPDLVIMDITMPVKNGIEALKDMIQLNPKVKVIMCTAMRQKRIVVEAIEAGAKDFIVKPFEETKVVEAIRHVLGN---
+----TRVLIVDDAAFMRMMVKDILSKNGYEIVGEAENGMKALEKYQELKPDLVTMDITMPEMDGITAVKEIKKVDPAAKVVMCSAMGQQAMVIEAIQAGARDFIVKPFQADRVLEAIRKAV-----
+----TRVLIVDDAAFMRMMLKDILTKNGFEVVGEAENGKMAVQMYSELKPDVVTMDITMPEMDGLAAVKEIKQQDPNAKVVMVSAMGQQAMVIEAIRAGAADFIVKPFQPDRVLEALSKAL-----
+----TRVLITDDSALARKQLARSLPSTIHADVTFAENGKIAIEQLQASRFDVMFLDLTMPEMDGFETLEMMRTNNINVPVFVVSGDIQPKAQERVLSLGAKAFVRKPVSQENLAQLLV--------
+----TRVLILADAPVLRRGLVSMINTAGMQSVGTPGELRRALTLVETARPDTVVVELGQGRAATLNACRDLRRRFPRVTIVALGTSEDPAVVNEALAAGVRGYLMINTSPT---------------
+----TRVLIIEDEWVIALDLKTLVTDLGHEVVGVAPTHTKALELAKDGDFGLVLADIQLAGSSGIDAVTDILGS-FDVPVIFITAFP--DRLLTGERPEPTYLITKPFLSETVKATIAQAL-----
+----TRVLIIEDEWVIALDLKTLVSELGHEVIGVAPTHAKAVELAKAGNFGLVLADIQLAGSSGIEAVTEILES-FNVPVIFITAFP--DRLLTGERPEPTYLITKPFLTETVKATIAQAL-----
+----TRVLIIEDEESYREATAFMLRKEGFE-VNTAANGADGLEIYSRNGADIVLLDLMMPGLPGTEVCRQLRQR-GNVGIIMVTARDSEIDKVVGLELGADDYVTKPFSHRELVARIRAVTRR---
+----TRVLIIEDEESYREATAFMLRKEGFE-VNTAANGADGLEIYSHNGADIVLLDLMMPGLPGTEVCRQLRQR-GNVGIIMVTARDSEIDKVVGLELGADDYVTKPFSHRELVARIRAVTRR---
+----TRVLIIEDEESYREATAFMLRKEGFE-VDTATSGSDGLETYSRNGADIVLLDLMMPGLPGTEVCRQLRQR-GNVRIIMVTARDSEIDKVVGLELGADDYVTKPFSHRELVARIRAVTRR---
+----TRVLIIEDDVAIAQLHHKYLNQMGFDVVGIATSQAEAEMQLEVLKPDLVLLDVYLPDGTGLDILQWVRGRNACCDVILITAARDVETLQQAMRGGVVDYLLKPVMFPRLEAALKKYQARQ--
+----TRVLICDDSKMARKQLAKVLPDWNVE-IEFAENGQDALEQIAANAFDVLFLDLNMPIKDGYETLEALQGFSQAPVVIVVSGDVQPKAIERVKAMGAAAFHKKPAATEDIRTLL---------
+----TRVLICDDSKIARKQLARILPDWDVE-VGFAEDGQEALDILSTADFDILFLDLNMPVKDGYETLEALKSFNKSPAVIVVSGDVQPKAIQRVKNLGAVAFHKKPASAEDLRSLL---------
+----TRVLIAEDHEIENIGVINTLKELNITDYAFTNYCDDAYKLIAEHPFDVLVTDLGFISTSGQELIRDARALQPNLKIIAFSIEKRAAVIDELFEYGVDGFVSKGNDGRELRSTLLKVMA----
+----TRVLIAEDDEDLRTNMVDILELEGFD-VIAVPSAEEAILACQTHSFDIALMDLVMSGMTGVEAISNLRQENPFMAVVIVTAYATVDTAVDAMKKGADSVLTKPFKSVDLVMTIRRSIAEK--
+----TRVLIADDSEFMRNLLREILEGE-FEIVGEAENGVEAVNMYEEHGPDLVMMDIVMPIRDGIEATTEILETNPEATVIMCTSVGQEEKMKAAIKAGAEGYITKPFQKPNVLDAIGS-------
+----TRVLIADDQEMVRAGFALILAQPGIDVVAQCADGVEALEAARRLRPDVALLDVRMPRLNGLEVTRRLAGVLDPVRVVVVTTFDLDEYVHAALRAGACGFLLKDAGPTLLVEAVRAAA-----
+----TRVLIADDQALLRGSFRVLVDSAGLEVVGEASDGAEAVALTRLERPDVVLMDVRMPEMDGIEATRRICAE-TDVRVLMLTTFDLDEYVYSALRAGASGFLLKDTRPADLLAAIEVVA-----
+----TRVLIADDNAIFREVIKRHVVLFGFE-TVEAADGAAAVALAEAGRPDLILLDLMMPGMDGIEAIRRIRAAMRDVPIVFLSAETDRRKWAEALSAGANDFISKPYHRQELEARLSLHL-----
+----TRVLIADDHAVVRDGLKHILERAGFDVVGEAADGSQVLKLVRDCAPQVLLLDLSMPGRSGLELIRLLRDEQQALRILVLTMHAEQQYIVRAFQAGAAGYLTKESAATELVSAITQVA-----
+----TRVLIADDHAVVRDGLKHILERAGFDVVGEAADGSQVLKLVRDCAPQVLLLDLSMPGRSGLELIRLLRDEQPALRILVLTMHAEQQYIVRAFQAGAAGYLTKESAATELVSAITQVA-----
+----TRVLIADDHALVRDGLRHILQTSGFEVAGEASDGSSTIALVRSRPAEVLVLDLSMPGRNGVELIRQIKDEMPALRILVLTMHAEQQYAVRAFKAGASGYLTKESASAELVSAVSKVA-----
+----TRVLIADDHALVRDGLRHILQASGFEVTGEANDSVSTVALIRERAADVLVLDLSMPGRNGVELIKQIREEKPALRILVLTMHAEQQYAVRAFKAGASGYLTKESASAELVAAVTKVA-----
+----TRVLIADDHALVRDGLRHILKASGFEVVGEADDSASTVALIRERAADVLVLDLSMPGRNGVELIKQIKEEKPTLRILVLTMHAEQQYAVRAFKAGASGYLTKESASAELVAAVTKVA-----
+----TRVLIADDHALVRDGLRHILKASGFEVIGEADDSASTVALIRERPADVLVLDLSMPGRNGVELIKQIKEEKPTLRILVLTMHAEQQYAVRAFKAGASGYLTKESASAELVAAVTKVA-----
+----TRVLIADDDSVVRDVVRRYLERDGLE-VAIARDGTEALRLLGTERIDVAVLDVMMPGPDGVTLCRTLRQREHTVPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRRS--
+----TRVLIADDDSVVRDVVRRYLERDGLE-VAIARDGTEALRLLGTERIDVAVLDVMMPGPDGMTLCRTLRQREHTVPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRRS--
+----TRVLCIEDNLSSQALIETLLQRPGVQ-LLSSMQGQLGLDLARQHLPRVILLDINLPDMTGIDVLKRLRALTAAIAVLMITADASTAARRAMQQAGATAILTKPIHVPTFLAFLDQHL-----
+----TRVLCIDNEVAIREGMRVLLAGWGCE-VEAYGSASEAIPDLGRRAPDIALVDYHLDEGTGLDAVTALRRFGPELPVILVTADRSPGLREQAAGMEV-DILTKPLKPASLRAAMG--------
+--TRVKCLLVDDLEENLLALGGLLRRDDVE-VLQARSGGEALEMLLLHDVALAFVDVQMPEMDGFELAELMRGRTRHVPIIFVTAGVRDHRLFKGYDAGAVDFLYKPLEPHVLRNKAEV-------
+----TRVIVVDDSAFFRSSITKMLTDSEIEVIGVAKDGIEGLEKIKNLKPDVVTMDIEMPKLDGISTLKIIMDE-MPLPVIMVSSLTKEEATLKALEFGAVDFIPK--------------------
+----TRVIVVDDEPLALVSMEKHLNEFNIEVIRTFTTAKDVLKEGPNLDFQVAFLDVEMPGMSGLEIAQLIKTWDKNICIIFVTAYR--DYAVQAFDVQSLDYLLKPVSKSRLEMTINRIQ-----
+----TRVIIVDDQAMVRAGFAALLAQSDIDVVGEAPDGAQGVELSRRTHPDVVLMDVWMPEMDGLEAARRLLEVTHRPRVLMLTTFDVDDYVYEALRAGASGFLLKNAPPADLIAAVRVVA-----
+----TRVIIVDDQAMVRAGFAALLAQSDIDVVGEAPDGAQGVELSRRTHPDVVLMDVRMPEMDGLEAARRLLSVTHRPRVLMLTTFDVDDYVYEALRAGASGFLLKDAPPADLIAAVRVVA-----
+----TRVIIVDDQAMVRAGFAALLAQSDIDVVGEAPDGAQGVELSRRTHPDVVLMDVRMPEMDGLEAARRLLEVTHRPRVLMLTTFDVDDYVYEALRAGASGFLLKDAPPADLIAAVRVVA-----
+----TRVIIVDDQAMVRAGFAALLAQSDIDVVGEAPDGAQGVELSRRTHPDVVLMDVRMPEMDGLEAARLLLAVTHRPRVLMLTTFDVDDYVYEALRAGASGFLLKDAPPADLIAAVRVVA-----
+----TRVIIVDDQAMVRAGFAALLAQSDIDVVGEAPDGAKGVELSRRTRPDVVLMDVRMPEMDGLEAARRLLDVTHRPRVLMLTTFDVDDYVYEALRAGASGFLLKDAPPADLIAAVRVVA-----
+----TRVIIAEDQKLLRESFKNIIENSDIKVVACATNGNEAYDLCKEYMPDVVLMDLSMPICNGTEATKLIKAELPSVKVLVLTASNDKSDVTDAISNGADGYILKDISTEELILSIKS-------
+----TRVFVVDDHEVIRRGIAALVNESDLELIGEASTVAESLALVPQANPDVAVLDVRLPDGNGVELCRELQSRRPGLRCLMLTSFDDHDALMDAIIAGAAGFVLKGVVSEELVNAIRTA------
+----TRVFLVEDHPLMRQGLVAALGQVEIAILGEAESGEEALAALAERTPDVVVMDIGLPGLSGIETTRRLKAARPDLRILMFTVHQLEGEIFGAFSSGADGYCLKDSELDSLILGIQAV------
+----TRVFLVDDHEIVRRGLVDLLGSVDLEVVGEAASVGEAMARIPGSGADVAVLDVRLPDGNGVELCRDLRTALPELQCLMLTSYSDDEALFDAIMAGASGFVLKQILGTDLVAAVRTV------
+----TRVFLVDDHEIVRRGLVDLLGSVDLDVVGEAASVGEAMARIPGSGADVAVLDVRLPDGNGVELCRDLRAALPELRCLMLTSYSDDEALFDAIMAGASGFVLKQILGTDLVAAVRTV------
+----TRVFLVDDHEIVRRGLVDLLGSADLTVVGEAASVGEAMARIPSSGADVAVLDVRLPDGNGVELCRDLRTVLPDLRCLMLTSFADDEALFDAVMAGASGFVLKQILGTDLISAVRTV------
+----TRVFLIEDNPEMLDATQMLLQRWGCE-VLPLESQDPTLLDT-QCECDVIIADYDLGKISGIEYIQAIRNKAEQIPALLITGHDV-TNISIFVKDLNIEIVSKPIKPVELRSVLTDIVRKT--
+----TRVFIVEDHAFTRDGLRVAVGREDLQVVGEARSAEEGIEQLAHTSADVVLMDIGLPGMDGIEATKLVKER-FGVRVVVLTVHQLEAEVLAAMTAGADAYCLKSTDPASLLLAIRAA------
+----TRVCLVDDQTLVRQGIRSLLADDGIEVVAEASDGKQAVEQIPQIQPDVVLMDMRMPVMSGLEALQMLSRNGALPPTIILTTFDDDQLVLAGLKAGAKGYLLKDVSLEQLVGAIRTVA-----
+----TRVAVADDHPIVQRAVAECLNALGFQVVATATSGGSLLTELTHHEVDLIVTDYNMQDKDGLRLVSHLLRVHEGTPVVVFTMLTNPGVLTQLCRMGVAGLVGKDEELTELGQVCLRVVR----
+----TRVALIDDHESVRLGLEAALAQTAAT--EVVFSGANVAAYLDQSPADVVVLDLTLG--DGTTVSENVDRVRDGSSVIIHSVADRPAAVREALAAGAAGIVSKSSPTHEVLGAIGTVAR----
+----TRVALADDHAIVLEGLKQVLSGVGNLVAGEAADGAQLLGLLERVPTDLLVMDLGMPGVDGLAFVERLRTRHPALRILVLTGSAGAGMAHAAIDAGANGYLVKSGDISELVPALMAL------
+---TRTVVVYSDDATVRERVRLALGRRELR-YIECATQYAVLEAADHENVDLFILDGEAVPAGGMGLCRQLKDEYRCPPVIVLIARRDDGW--LATWSRADATVLHPVDGVRLTPVVVDLLRRR--
+---TRTVLIIEDEAAIAETICYALSTDGFQ-PHWRATGREGIACAEALRPPLVLLDIGLPDSNGFEVFRSLQSRFETPPVIFLTARSEEVDRVVGLELGADDYIGKPFSPRELCARVRAVLRRS--
+--TRTRVMIVDDHEIVRRGIAEIVDRAGLEVVAEAGSVQDALRRAELVRPDVILVDLQLPDGTGIDIMDSLGRTHPEVLPIVLTSFDDDEALAESLDKGARAYVLKTVRGAEITDVIKAVA-----
+----TRTLLVDDDRSCVVLMMRILEILGQREIDVASDGQAAYAMMRTKEYGLVVSDLHMKPWSGLDLLRRVRALLRKTPFVLTTMDTEIANVGDARDCGADAYILKPYTPAMLREKIEPLLRRQE-
+---TRTILVADDDRAIRTVLSQALGRAGYT-VRATSSAATLWRWVEEGAGDLVITDVVMPDENGLDLVPRIKRVRPELRVVVMSAQSTFMTAVKAAQRGAFEYLPKPFDLKELLAVVARALT----
+--TRTDVLIIEDEPIIAMDLETIVRDLGHSVSGVAVTRDEAVAQAHAHRPGLVLADIQLADSSGIDAVKDILAE-FSVPVIFITAFP--ERLLTGERPEPTFLITKPFQRSTVKAAISQAL-----
+---TRSVVVADDHPIVLRAVTDYVNSLGFRVVASVSSGDALLSAMREQEVNLVVTDFTMHDKDGLRLISHLMRAYERTPIIVFTMLTNSGVISQLCRMGVAGLVGKEEEIAELGRVCLNVAR----
+---TRSVLLYSDDAPVRAQVRQALGSHDLE-WHEVATYDALVERVIPGRFDLLILDGEARKAGGMGVARELKNQYNCPPILVLTGRA--QDAWLASWSLADAVVPRPLDALTLSDTVEGLLE----
+---TRSVLLVDDSAFFRNMLGPVLKAAGYK-VRVATSAVEGLAVLRSAQFDVILTDIEMPEMNGFEFAEAIRAKMSNLPVIALSSLVSPGAIERGRQAGLTDYIAK-FDRPGLIAALKE-------
+---TRSVLLVDDSAFFRNMLAPVLKAAGYQ-VRLATNAQEGLVALRSQEFDAILTDIEMPDMNGFEFAETVRSRLSDTPIIALSSMISPAAIERGRQAGFHDYVAK-FDRPGLIAALKEQT-----
+---TRSVLIVEDEEIIRTSLLEFLTDEGYQ-AMAAPNVATALKLAREREFQVAVCDVQLPDGDGLALLRKLQQITPGVSGLIITAYATVENAVEAFKSGAFDYLVKPVIFDDLANKLARLFQ----
+---TRSVLIADDEPLARERIRRLVEAVGYRVCGEAADGDSCLKQVAELEPDILLLDIRMPGMDGMEAASRLSQLANPPALIFCTAYD--HYAIQAFDVQAIAYLLKPVRKEALAEALARA------
+--TRSRLCLIEDDEIIGESLTDRFRLEGFD-VDWCRTGVEARAALAAHRHAVVISDIRLPDCNGGELFLDLLASVPMLPFLFMTAFGSIDRAVELIKAGAADYITKPFDPDALIAKVHALAE----
+-------------------TRSKLESMDYI-VTTFTDETEALSAVVKNRFHVAIVEVNTRENESFKFLEGAKD---VLPTIMISTDHCITTTMKCIALGAVEFLQKPLSPEKLKNIWQHVVHKA--
+--TRSKILIVEDNEELRGLLARLFSKI-YT-VYEAQDGEEGFEKTKEVQPDIVLSDIMMPKMSGIEMCRKIKSETSHIPVILLTAQTAEEYTMQGLKMGADDYVTKPFNVKHLFMRCNNLVNS---
+--TRSKIIIVEDNEELRGLLARLFSRI-YT-VYEAQDGEEGFEKTKEVQPDIVLSDIMMPKMSGIEMCRKIKSETSHIPVILLTAQTAEEYTMQGLKMGADDYVTKPFNVKHLFMRCNNLVNS---
+--TRSKIIIVEDNEELRGLLARLFSKI-YT-VYEAQDGEEGFEKTKEVQPDIVLSDIMMPKMSGIEMCRKIKSETSHIPVILLTAQTAEEYTMQGLKMGADDYVTKPFNVKHLFMRCNNLVNS---
+-------------------TRSELESMDYI-VTTFTDETEALSAVVKNPFHIAIVEVNMSESESFKFLEAAKDV---LPTIMISTDHCITTTMKCIALGAVEFLQKPLSPEKLKNIWQHVVHKA--
+---TRRVVVAEDEAIIRLDIVEMLTEAGYDVVGQAGDGEQAVALAEEHKPDLVVMDIKMPILDGISAAERIAKA-RIAPVVLLTAFSQAELVERARDAGAMAYVVKPFTSADLLPAVEIAVSRH--
+---TRRVVVADDHPIVLRAVTDYVNSAGFHVVASVSSGDALLSAMREQEANLVVTDFTMHDKDGLRLISHLMRAYERTPIIVFTMLTNSGVISQLCRMGVAGLVGKEEEIAELGRVCLSVAR----
+---TRRVLVVEDEPVINQAVSDRLTAEGYD-VVRAWDGPGAVSCFEETSPDLVVLDVMLPGYDGLEVCRRIQAV-RPVPVLMLTARVDEADVLVGLGVGADDYLTKPFRARELVARVNALLRRV--
+---TRRVLVVEDDRKMADALVSGIKAAGYD-VSVARTGEEGFFLVHKLFPHLLVLDLHLPQRNGLEILQQIRAQALDIRILILTSNNTPEDRVTGLNAGADDYLGKPFSFPELLARIGSLLRRM--
+---TRRVLLVEDDAHIADLLTLHLRDEGLE-VMHCARGDDGLRQLERGGWDALVLDIMLPGVDGLEICRRARAMARYTPIIIISARSSEVQRILGLEIGADDYLAKPFSVLELVARVKALLRRV--
+---TRRVLLVEDDAHIADLLTLHLRDEGLE-VMHCARGDDGLRQLERGGWDALVLDIMLPGVDGLEICRRARAMARYTPIIIISARSS--------------------------------------
+--TRRTVLVVEDNDANFALMQRLLESTGLWTIVRATRVTEAEAELARGKPAAMLLDLDLPDTDGLTLARRVKAALRDIPIVVVSASVMKQERDRAEAAGCEYFVEKPFDIDRLRSVVAEA------
+--TRRTVLVVDDTVDNLTLLSDLLKD-TYR-VKVANSGEKALRILSSSPPDLVLLDIMMPGMDGYTVLRRLKELTADVPVIFLTALSEEDDERIGLELGAVDYITKPISPSIMLARVRTHLQ----
+--TRRRVVLADDSPTTRALEQSILESAGYE-VVACVDGADAWERLQSGGADALVLDVEMPRMDGFALTEAVRARFSRLPVVLVTARGKPEDKARGLQAGASAYLVKSFDPTSLLETLRRLL-----
+-TRRLRVFLVDDHAMFRAGVRAELGAH-VDVVGEASTVGEAVSRIAATEPDVVLLDVHMPEGGGRAVLEAIRRTYPHVRFLALSVSDAAEDVIGLIRAGARGYVTKTISPDELAAAVRRVAE----
+---TRRLLVVEDDDSIRETVGEALRAEGFE-VHTCADGASALTLITADPVDLIVLDLMLPGLGGLDLCRELRRLNNTTPILVISARDSETDRVLGLEVGADDYLVKPFGLRELVARCRALLRRSS-
+---TRRLLLAEDAPENRLLFKAYLKGTPYL-LDLAVNGEEAVVKFKQGHYDLVLLDIQMPGMDGYAAARAMRAGREAIPIVALTAHAFRDDIRKSREAGCDGHMVKPIKMDDFLRTIRTYI-----
+---TRRILLVEDDEAVADSLAMLLQIQGHE-VRIIHRGKQTLEAVQSFQPEVVLLDIGLPDRDGYGVARQLRQELENLPLVALTGYGQSEDIQQAKAAGFNRHLLKPATVETLQKLLG--------
+---TRRILLVDDEPSLQKMLTHALEREGFQ-VQAVGDGEAALEAFNTFEPHLIILDIMLPKLDGTEVCRRIRAQ-SDVPILMLTAKDDEIDRVVGLELGADDYVTKPFAVRELVARVRAIMRRAQ-
+---TRRILLIDDDVELAQMLREYLEPGHCQ-LTLAHSGAHGLALLAQDDYDLVLLDLMLPDGNGLDLLKQYRQR-SRRPVIMFTAHGGETDRVLGLEFGADDYLAKPFSPRELKARISAVLRRF--
+---TRRILLIDDDVDLALMLREYLEPTHIE-LTLAHNSAQGLPLAMQECFDLVLLDLMLPDGNGLDLLRHLRRH-SRRPVIMFTAHGGETDRVLGLELGADDYLTKPFGPRELKARIGAVLRRF--
+---TRRIALVDDHRMFSDGFSALLMQLGHI-VDVFDDPVDFLKSFQSDSYDLIILDLVMRTMNGLALLAAIRERKSRCPVLMLSGIGADPPLAEMKKLGARGFVHKSADTETLLAAVDGILA----
+---TRRAVVVDDEQALALLVAGYLERDGFE-VQLCFDGAQAVELIRQVDPDVVVLDLGLPGLDGIEVCRGLRT-FSDCYVLMLTARAEGVDTLIGLSVGADDYMTKPLSPRELMARIEVLLRR---
+-TRQLHVLVVDDDRYVRPVLVRLLQRHGFR-VTNVADGLTALTIIEQARPDVVLLDVKMPGIDGTEVLRRIKELTAMTRVIILTANDLESLQSQVLRLGADGYLEKPITYERLISMVM--------
+--TRQKILVVDDESANLHLLEQSLTDLA-E-IICSTGGQDALDKAEQHQPAIILLDIEMPQMNGFEMCKRLKNKTCNSAVIFVTAHSESSFEYKSLSSGGIDFIHKPIDLATCRLRVKNH------
+--TRQKILIIDDEAALRETLEALLSLEGYE-VETAIHGEAGLEKIDRNSYDLVLLDLALPGKNGIEILGLIRDRNADLPVIMITAFGTVDNVMDAMRAGAQNFIQKPWDNEKLLADIRSAIARHQ-
+--TRPTVLFVDDESMLLSSLQRLLRREPFT-ILLAVSAREAMEIMARTPVDVLVVDLQMPDIDGYELLSRVEVLHPQTVCLVMSAVADKEKVEEVVRHHVFKFIAKPIHPDVLKRVIRDSV-----
+--TRPTVLCVDDEIRSLETLERTLDE-EFN-VITATDADQAMALLEQHNVQAILCDQRMPGRTGVEFLTDVRKRWPQTARLILSGYTDSEDIIKGLEAGILQYITKPWHPDNLLLIMRGACR----
+--TRPTLLVVEDDPGLLGQLRWCFED--FE-VATATTRDEAIAQLRRSEPSVVTLDLGLPASEGIATLEQILTLAPDTKVIVVTGNSDRENAVKAVGLGAYDFYQKPVDADLLNLIVKRAQ-----
+--TRPTILIVEDIVFIRMMTEDYFANAGFR-TLSARTTAEAIVLLETDPIRYLFADIHLPGEDGQKLAATARKRWPPVKIILTSADM-PADQVRLPVRGL--FVPKPYSLDRVRQAFE--------
+--TRPSVLLVDDNDVNLKLLVAFMKKAKFP-YLTASNGLEALEVYKAHQVPVVLMDISMPVMDGLESSREIRSSFKPTTIIALSGLGSAPVRQEAFNSGVDLFLSKPIRFQELVKQIDDLMR----
+--TRPRILVVEDEITIREFCRLLLRR-EYD-VAVAEHGQAAIELLNIQPFDLVVTDLQMPHLDGLALVQYLRTHCLETDVIVMTAHATVETAREALKLGALDYISKPVDAEQLQKTIRTALE----
+--TRPRILLVDDNAVNRKVVKLQLKKLGYD-CDTATNGFEGFEMQKKDNYELIFMDLNMPLCDGSMASKLIRSHKSRANIVGLSATYLHGSKDYCVSMGMDDFVVKPLKLQPLGELVKKYLE----
+--TRPKLLIVEDDPGLQRQLRWAYDA--YR-VFIAGDREEAIDMLRAEAPDVVTLDLGLPTSEGFATLADMLRIKPDTKIIVASGHGERESALEAIAGGAYDFYQKPVDIHELGLIVRRAFH----
+--TRPKILAVDDEDFNLDILGEILDEAGYQ-PVLAVDGREALALLELHPIEVIVLDRMMPNMDGMACLAALKSRWRDLPVIMQTAAASHDQVRQGIEAGVFYYLTKPYAADILLSLVRSALDD---
+--TRPDIIIVDDNPHNLRVLSTILKKEGYE-IRPATGGQTALAAIDAKPPELILLDIMMPAMNGYEVCECLKKNTRNIPVIFITALDDVKDKIKAFAMGCTDYISKPFQEEEILARVKTQI-----
+--TRNRILIVDDEDNVRRMLTTALTLQGHE-THAASHGAEALQRFADAPPDVVLMDIRMPTMNGIDALKVMRARQPRTPVILMTAYAEVETAVEALRSGAFDYVIKPFDLDELNLLIQRALQL---
+---TRNILVADSHPVARLGVSTLLEQFDID-IYIASSFEELQSMLFVVKYDLLIMEIELPNGNWVAIIDQILSVQKDLKIIILSKQDNKFLASASFMKKTFAYVSKDQSIEYIRNVIQTVLS----
+---TRNILIADSHPVARLGVSTLLEQFDID-IYIASNFEELQSMLLVVKYDLLIMEIELPNGNWVAIVDQILSVQKDLKIIILSKQDNKFLASASFMKKTFAYVCKDQSIEYIRNVIQTVLS----
+--TRNHVLVVEDDADIAGLVVHEASQLGYD-VTTADTVDGAKRRTSEQMPDIVILDRMLAGSEGLDYLAWLNAEGPRPGILVTSRLTSVSDHVAGLEAGADDYIDKPFHPEELRARLRAVARRAS-
+---TRMVLIVDDEPSMRTALSETVRRLGYQ-VRGAIDGVDAIEQIERIKPWLVVTDLKMPRLTGLELVKAIKQKSPQTFIVLMTAYGTVETAVEAMKYGANDYLLKPFSTDLLERVILNLQ-----
+--TRMKILVAEDFELNVKLMKRIAKKHHLT-MDFASNGREVLDKLNDQSYDLVLMDIQMPVLDGIEATKLIRRRFAHIPIYALTADSDLVQQEVCTDAGMNGYITKPIKADKLFTLLAEL------
+--TRMKILLADDHHEFAELLSEFISQPDMEVCGIAHNGTEVLNLVRETRPDVLILDIIMPVLDGLGALERLSETDHPPKVIMLTAFGQESVTRRAVELGVSYFILKPFDMPVLAERIRQVMF----
+--TRMKILLADDHHEFAELLSEFISQPDMEVCGIAHNGTEVLNLVRETRPDVLILDIIMPVLDGLGALERLSETDHPPKVIMLTAFGQESVTRRAAELGVSYFILKPFDMPVLAERIRQVMF----
+--TRMKILIVEDDLEAAAYLAKAFREAGIV-SDHASDGESGLFMASENAYDALVVDRMLPRRDGLSLISELRRRGIHTPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLGRRK--
+--TRMKILIVEDDLEAAAYLAKAFREAGIV-CDHASDGESGLFMASENAYDVLVVDRMLPRRDGLSLITELRRKDIHTPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLGRRK--
+--TRMKILIVEDDLEAAAYLAKAFREAGIV-CDHASDGEAGLFMASENAYDVLVVDRMLPRRDGLSLITELRRKDIHTPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARVEVLGRRK--
+--TRLVILIVEDNKDILDYIAESFTDL-YE-VKTALNGKEGMEIALECIPDIIVSDIMMPVMDGITLCKQLKNRTSHIPIILLTAKDTLSDKEEGYQSGADSYLTKPFSASLLHSRINNLLAQR--
+----TRLVIADDESIIRMNLKETLVSLGYLVVGEAGDGVSVINLARELRPDLVLMDIKMPKLDGIQAARILTEE-KIAPVLLLTAYSDRDLVERAKEAGVVNYIVKPFREAELLPAIEIAIARY--
+--TRLRVLLVTDTDKPIGELGDALARLGYEMLNDVATPARLPAAVEEQRPDVVIIDTDSPSRDTLEQLAVMHAT-APRPVLMFSHDADQELIRAAVGAGVSAYLVEGLSAERLAPILEVALARF--
+--TRLRVLLVTDTDKPIGELGDALARLGYEMLNDVATPARLPAAVEEQRPDVVIIDTDSPSRDTLEQLAVMHAT-APRPVLMFSHDADQALIHAAVGAGVSAYLVEGLSAERLAPILEVALARF--
+--TRLRVLLIEDDDGDALLVEEMLADTSVP--YTLERVQTLTAALDGLTADCVVLDLQLPDAMGLSGLTKLGQHAPGVAVVVLTGQHDQATGVAAVAAGAQDYLVKDVDGPLLVKALRFARE----
+--TRLRVILAEDDVLLREGVASLLTRSGFDVLEQAGDATTLLDLVRERAPDLVMVDIRMPTTEGLDAARAIRDEFPEVGILVLSAHADVEHAMELLASGGIGYLLKSTDVDDFIDTLQRIA-----
+--TRLRVFLADDHPVVLSGMKALVADPAIEIVGEASDGPNALRRAIELKPDVAVLDLSMPGLNGIEVARKFLAACPECRVLVLTVHEDGAYLRQLLDLGVSGYVLKRSATEELIRGIHA-------
+--TRLRLLLVEDHAATLNAVSRLLRRDGHT-IVAVGTAAEAVKAAEVGEFDCVVSDIGLPDGSGLELMKTLRAR-HGLRGIALSGYGREADLIQAREAGCVAHLTKPVAIAELRATIASI------
+--TRLRILVIDDEPPIRKLLRMGLSSQGYE-VAEAGTGRAARQALAQAAVDLVILDLGLPDIGGHDLLRLIREGFPSLPVIVLSSRGDETGKVEALDLGADDYVTKPFGMNELLARMRTALRHQ--
+--TRLRALVVDDSAMMRRLVRETLSDPAFAVVGEAGDGRAALALMAELRPDLTMLDIEMPVLDGIGTLREWALSG-HGAVVIVSSAARPELAALARRLGASAVVGKPS------------------
+--TRLPVLVIDDHPIVLQGCRRVLEDSGVETIAEATTVVGGYRIFHRLRPPVVICDLTFQGMAGLGLIRRIRAVAPETRILVFSMHNDPVIVARALEAGALGYVLKDHASAELFEAFAKV------
+--TRLPILAVEDHPETLFIYENHLQHSIYQ-LIATRTLTQARQVLQKVRPAAIMLDIMLEGQNGWTFLRELKGTTRSIPVIVITIID---NEKQALALGADGFLIKPVDRLPLLKKLNTHR-----
+--TRLNVVVVEDSLAMQKLYRMTIESWQLPDVKFVSNGCEGIIYVSQHTPDLLITDLKMPEMDGFAMLKSLRDDFSKMAIVVVTGMQAQEIEEKGLPKGVRLYGKSPVPFWEMRELMQGLIDRK--
+----TRLMIVDDEERFLKTTKGLMEKRKCI-VSTALSGIEALEILAKQEMDVVILDVKMPGMDGVEVLRRIKQTHPLVEVIMLTGHSTTESAVEGMKLGAFDYLLKPCDINILFSKVMEAVDKK--
+----TRLMIIEDEPLIAMDIEQMVESLGHEVVGIARTKDEALALYEKEKPRMVLADIQLAGSSGIDAVNEILHD-NTIPVIFITAFP--ERLLTGERPEPTFLVTKPFNSDMVKALISQAL-----
+----TRLMIIEDEPLIAMDIEQMVESLGHEVVGIARTKDEALALYEKEKPRMVLADIQLAGSSGIDAVNEILHD-NTIPVIFITAFP--ERLLTGERPEPTFLVTKPFNPDMVKALISQAL-----
+----TRLLVVEDEESFSEALSFMLEREGFD-VAVAADGHAALSDFERHGADLVLLDVMLPGLSGTEVCRALRQK-SSVPVIMLTARDSEIDKVLGLELGADDYVTKPFSARELVARIRAVLRRRG-
+----TRLLVVEDEESFSDALSFMLEREGFE-VGVVADGPSALAEFDRRGADLVLLDLMLPGLSGTEVCRTLRTR-STVPIIMLTARDSEIDKVLGLELGADDYVTKPFSARELVARIRAVLRRR--
+----TRLLVVEDEESFSDALSFMLEREGFE-VGVVADGPSALAEFDRRGADLVLLDLMLPGLSGTEVCRTLRTR-SSVPIIMLTARDSEIDKVLGLELGADDYVTKPFSARELVARIRAVLRRR--
+----TRLLVVEDEESFSDALSFMLEREGFE-VAVVGDGPSALAEFDRRGADLILLDLMLPGLSGTEVCRTLRAR-STVPVIMLTARDSEIDKVVGLELGADDYVTKPFSARELVARIRAVLRRR--
+----TRLLVVEDEESFSDALSFMLEREGFD-VAVAADGLAALTEFERHGADLVLLDLMLPGLSGTEVCRALRQR-STVPVIMLTARDSEIDKVVGLELGADDYVTKPFSARELVARIRAVLRRRG-
+----TRLLVVEDDPDLGLALRVLLARRGYE-VSVAEDGREGLRLLFAERPALMILDLLLPELDGWQVLDRTRDM-SDLPVLVLSGLGDVDDRVRGLRSGADDYLVKPFAHPELLARVDALLRRS--
+----TRLLVVEDDDTIRETIAEALSSEGFE-VDAVGSGSTALERFKGSPCDLVLLDLMLPGVSGLDVCRYMRRRGFSTPIIVVSARDSETDRVVGLEIGADDYLVKPFGMRELVARCRALLRRS--
+----TRLLVVDDNDTCRKVLLQQCNAWGMN-VSSVPSGKEALALLRTRAFDVVLLDQDMPGMSGMQLAAKIKELNNDILIIMLTGISHAPSKIIARNAGIKRILAKPVAGYTLKATLADEL-----
+----TRLLVVDDNAENRNMLRMLLTSWGVR-VSEVSCASTAIERLRQDPFRIAIIDMEMPEIDGLMLGRSIKDALADTALLMMNSIGRRPDNEKLRRSGFFSFLVKPVRQSELYNTVSEVLF----
+----TRLLVVDDEQDIRYLFQCELEEEGYH-VDAAGSAAEAERFLRENRYDLVVLDIQIGGDNGLAMLQDIIGRQKDLPVILCTAFS--CYKEDFSSWLADGYVVKSSDLSELKSEIQRVLTKKG-
+----TRLLVVDDEPAILDVLATSLRFLGYE-VAEATTGRAALTAAREGGFHLVLLDVVLPDLDGFAVVRRLREGGGRVPVVFLTARESPEDIVAGLDLGADDYITKPFRLAEVAARVRAVLRRR--
+----TRLLVVDDDTTHRGMLQTLLADWGYR-TECAGDGETAVTLCRETPFDLILMDLRMGVMSGIGALREIRAYNPAIPILIMTAYSNVESAVDAIRSGAYDYLTKPLDFEELRLTLERALDHA--
+----TRLLVVDANPTRREQLARTLQTIGIL-TLLAESLAEARPLMNNRTAGLILDETAISTAEASQAINELRHLDRQLPAIFMSALKSDLGSDLGAALDDVVILWKPVKQSALYQALRSI------
+----TRLLVIDDDRKLCRLIKDYLEPMGYE-IALAHTGPEGAEKAVSETFAAVILDVMLPGMDGFEVLKQIRRA-SNVPVLMLTARGDESDRIVGLEIGADDYLPKTFSTRELLARLRAVTRRS--
+----TRLLLVEDDSAIAEPLSRALDREGYT-VTRASRGMDALGIAAGESIDLVILDLGLPDLDGLEVARRLRKGGLECPILILTARADEVDAVVGLDAGADDYVTKPFRLGELQARIRALMRRS--
+----TRLLLVEDDPISRAFFHITLESLPAQ-IDLADSVATALAHAGIRNHDLWLIDANLPDGSGTELLQQLQRQCPGAQGLAHTADASDTVREQLLRGGFAEVLLKPLSAEHLLQRVRWLLAR---
+----TRLLLVEDDPDLGRTVTQALEEHGFQ-VVWATSQEEAWEALWDVPFQALVLDVRLPEEAGFHLARTLREAGFTQPILFLTAKDALDDRLHGLELG-EDYLTKPFALSELVARIRALLRRG--
+----TRLLLVEDDDALVRTLELTLGVHGFD-VHATGLGAQALVLARTFQPEIAIVDLGLPDLDGLEVVRALRA-WSDVPVLVLSARDAQHDKVGALDAGADDYVTKPFGMDELLARLRAALRRV--
+----TRLLLVEDDANLCYIIRGGLEDMGYE-IQTAADGEEGLRIWKTWKPDVIVSDIEMPVMDGYEMVRRIRETDERTPILFTSGRVSPKDVVKGYELGVNNYIKKPFLPEELHAHVTALLR----
+----TRLLLVDDQPMLRIGFRMVFEQPDIEVVGEAGDGERAVAMTRALSPDVVLMDVRMPVVDGIQATRRIVETGSAARVLVLTTFDLDEYVFAALRAGASGFLLKDVPPEDLLGGIRAVA-----
+----TRLLLVDDDEIFCQVLAKALGRRGFD-VLTAHSIEQALRQLDETGPDYAVVDLSMPGGSGLVLVEQLHARSAKMRIVVLTGYASIATAVEAIKLGAIHYLSKPANADEIVQA----------
+----TRLLLIDDDTALCELLSEYLALEGYA-VEAVHDGEAGLAAALSGRYRLALLDVTLPRLNGFEVLKRIRQE-SSLPVLMLTARGDDFDRVVGLEIGADDYLPKPFNHRELVARIKAILRRT--
+----TRLLIVEDNRDILANLADYLTLKGYE-VDCAQDGLTGLHLAATHHFDLIVLDVMLPGMDGFTLCKRLREERSDTPIIMLTARDALDDRLIGFSAGADDYLTKPFALSELVARIEAVLKRS--
+----TRLLIVEDEPLLRAVQSEMFTSMGFI-VDAAADAQSAYKSWIQYQHPMIITDCRLDNSDGFELVLHLRKNSESVLIIGQSASLKDDDYMRAKEVGMNHIMRKPVSVKTWHSLI---------
+----TRLLIVDDSALMRRVLGDVFQEPGFE-VAFARDGVEALAQVHAFRPDVITLDVQMPRMDGLSCLDRIMVE-RPCPVVMVSSLTAEDATLEALELGAVDFVAKP-------------------
+----TRLLIVDDNDTCRKVLVQQCSGWGLD-VSAVASGKEALALLRTKAFDVVLLDQDMPGMTGMQLASKIKELNHDILLIMLTGMSSAPSKIIARNAGIKRILAKPVAGYTLKTTLADEL-----
+----TRLLIVDDEALVRAGLKMILESADLQVVAEAEDGADAAAMVREHRPDVVLMDIRMPRLDGLAATREIQALPEPPKVVVLTTFDLDDYVFRALQAGASGFLLKDTPPRELVQAVRVVA-----
+----TRLLIIEDNPELVANLYGFFEPLGYV-LDDARDGATGLRMATQHDYDAILLDLMLPRLDGMALCRKLREEQNPVPVLMLTARDPVDDRVQGLAAGADDYLVKPFSLRELDARIQALVRRA--
+----TRLLIIEDNPELVANLYEFFEPLGYV-LDDARDGATGLRMATQNDYDAILLDLMLPRLDGMTLCRKLRQEQNPVPVLMLTARDPIDDRVQGLALGADDYLVKPFSLKELDARIKALVRRS--
+----TRLLIIEDNPELVANLYAFFEPLGYV-LDDARDGASGLRRATQDDYDAILLDLMLPRLDGMTLCQKLRQEQNPVPILMLTARDPVEDRVQGLALGADDYLVKPFSLTELDARIKALVRRA--
+----TRLLICDDHAMFRQGLRSILEEEGFRVIGEAATGREAVRYALETHPDVILMDIQMPELDGVAATKTILEEFPDAKVIILTMYRQDRYVFEAVKAGARGYLLKDAGADDLISAIRRV------
+----TRLLIAEDQKMLLGALASLLDEDDIDVIGTVNNGKEAVEAVKKEKPDICIMDIEMPEMNGLDAAELLKD--DPCKILILTTFARSGYFQKAMSVGVDGYMLKDSPSEELAEAIRQIMQ----
+----TRLLIADDEQIEREGLEVILQKAGVE-ISQAKNGKMAVQLAKAFNPDLILMDIQMPGLNGLEAIKQISEADPHIKFIMITAFDTFDYARQAIKLGVKDYLLKPSKITEIEATVGKVLEQI--
+--TRLKILVVDDTKTNIDVLEGILSN-DYD-VCVALNGKKAIELTEKIRPDLILLDVMMPEMDGYETLRIMREKLQGIPVIFLTAKADSKSEQIGLDLGAVDYITKPFNPALVTLRIKNQL-----
+--TRLIVLVVEDEPLLRMTAVDMVEEAGLT-ALEAADATEAIRILESRDIRIVFTDIDMPGIDGIRLAAVIRHRWPPIDIIVTSGHVDAGEVDLPARC---KFLPKPYDERLVIAAMRSF------
+--TRLIVLVVEDEPLLRMTAVDMVEEAGFT-ALEAADATEAIRILESRDIRIVFTDIDMPGIDGIRLAAVIRHRWPPIDIIVTSGHVDAGEVDLPARC---KFLPKPYDERLVIAAMRSF------
+---TRKVVVADDHPIVLRAVTDYVNSLGFHVVASVSSGDALLSAMREQEVNLVVTDFTMHDKDGLRLISHLMRAYERTPIIVFTMLTNSGVISQLCRMGVAGLVGKEEEIAELGRVCVSVAR----
+---TRKVVVADDHPIVLRAVTDYVNSAGFHVVASVSSGDALLSAMREQEVNLVVTDFTMHDKDGLRLISHLMRAYERTPIIVFTMLTNSGVISQLCRMGVAGLVGKEEEIAELGRVCLSVAR----
+--TRKTILVVDDDPHILEVLEVRLVSAGYD-VVPAANGLEALEVLSRQPVRLVISDMRMPGMDGMRMLEEMERRGIKLPIIFLTAHGSIPGAVEAIKHGAVDYLTKPFDGQELLARVTDVFAKA--
+--TRKTILAVDDDPHILEVLEVRLVSAGYD-VVTAGDGAEALEVLAKRPVKLVISDIRMPGMDGMRLLEEMERRGIRLPIIFLTAHGSIPGAVEAIKHGAVDYLTKPFDGQELLTRVTEVFARA--
+--TRKQILVVDDDLRLRGLVESHLQGFGFG-VRGMSDGRQIESLLAEAPVDLIVLDLGLPHEDGLQICRRLRQH-HDVPILMLTARGDEVDRILGLEMGADDYLAKPFHPRELVARIQAILRRV--
+----------------------------------------------TRKPDLVILDLGLPDGDGIDFIRDFRG-WSGAPLIVLSARSAEAAKVAALDQGADDDLGKPFGVAELLARVRA-------
+----------------------------------------------TRKPDLIILDLGLPDGDGLSYIQDLRQ-WSAIPIIVLSARNSEEDKVAALDAGADDYLSKPFGISELLARVRVALRRHS-
+--TRKNILIVDNNCELEQLVKEQLENSGFSVVVRAKDGAEAAIKSENQKFDVVLIDTEVPRMDGG-FVYGIHTNTQDAELIVISQRDS-SDLPESLQS--SKFFKKPVSPNELISAMISVLNA---
+--TRKKILIVDDSAVIRKSIEMALAETGYG-LISAATGEAAIKLATEQKPDLILLDVMLPDTTGLKVCKTLRSELKTTPIVMLSAKDAEIDKNLGLHAGANDYVTKPFKDGQLVEIVDKFLK----
+---TRKILLIEDNPEMRENTAEILELANYE-VLTAQNGKEGVQQASQHLPDLIICDIMMPELDGYGVLHMLGKRTASVPFIFLTAKAEKEDYRKGMTMGADDYLTKPYDDVELLNAVEMRLKKS--
+-----------------------------------TRKGDLLDALKQDKPALIVMDWNMAARKGYVVLSWLAQSWQVIPVVIMTDAHKPVDEVKCAQLGYELVLPKEPSYTKQLKQLRGLVR----
+----TRIVVVEDEIDIASVVQDYLRHSGYE-TAHFADGQSALESIVAAPPDLTLLDIMLPRLDGIEVLRRAREH-TAHPIIMLTARIEEVDRLLGLELGADDYVCKPFSPRELVARVRAVLRRT--
+----TRIVVAESDRDFRARLKEILRHAGYMVIGETQDGRSLLQMVFQTTPELVILEYRLPGSEGIDVAGIIEEH--HVAPVVLTADLHQQNVAELVRSGVYGVLPRPLQEEMVVPTIEMAMS----
+----TRIVVADSCTLLCQGLSRLLEEADLRVTGAYTRGREALRAVLETRPDVFLVDTRLEDVDAFVVVGEVRRARPEVRVVVFSAQPEAREVRQAYEAGAAAFVEKRADLGALLQVIRRVRR----
+----TRIVVAAYRTILVEGMVALLQKVGIEVVGHAEDGLACLQIAARERPDIVLVDVLLPGLNGIDLTRRLMQRSPNSRAICIAPSDACTQASAVFEAGAKAYLARTSRFAELLRAIQCVIQDQ--
+----TRIVLADDHVILREGLRALISQPDLEVVGEAASGTETVDCVRATEPRVLCLDLSMPGWGSATTITRVTQLAPRTRVLVLTMHNDPAYVRSALAAGAAGYFLKTTPSPDLLAAIRAVAT----
+----TRIVLADDHDLLRQGLTLLLQQADMRVVGEARNGLEAIKLVQEQRPDIVVMDISMAQLDGLEACERIRALAPGTQVLMLTMHESEEYFLQSLKKGAAGYIVKKAAPAELCNAVRTIA-----
+----TRIVIVEDELDIASVVQDYLRHAGYE-TTHFADGQSALDHLIATPPELTLLDIMLPRLDGIEVLRRAREH-TSHPIIMLTARIEEVDRLLGLELGADDYVCKPFSPRELVARVRAVLRRT--
+----TRIVIIDDEPQIRKFLDIALRTQKYK-TTLCETGYKGLETLATQGADLVILDLGLPDLDGREVLQELRS-WSNVPVIVLSVRADEYEKVALLDAGANDYMTKPFSVQELLARIRVILRNQ--
+----TRIVIIDDEPQIRKFLDIALRTQKYK-TTLCETGYKGLETLATQGADLVILDLGLPDLDGKEVLQELRS-WSNVPVIVLSVRADEYEKVALLDAGANDYMTKPFSVQELLARIRVILRNQ--
+----TRIVIIDDEPQIRKFLDIALRTQKYK-TTLCETGYKGLEALATQGADLVILDLGLPDLDGKEVLQELRS-WSTVPVIVLSVRADEYEKVALLDAGANDYMTKPFSVQELLARIRVILRNQ--
+----TRIVIIDDEPQIRKFLDIALRTQKYK-TTLCETGYKGLEALATQGADLVILDLGLPDLDGKEVLQELRS-WSNVPVIVLSVRADEYEKVALLDAGANDYMTKPFSVQELLARIRVILRNQ--
+----TRIVIAEDSAILREGLAQLIAERGHDVVAAVGNADDMLGAVREFAPDVVVVDIRMPTDEGLVAAVSLRRSHPEVGVLVFSQWVETRYATELLAGNAEGYLLKDADIAEFDAALQRVAAR---
+----TRIVIAEDEALIRLDLKEMLEEEGYTVVGEAGDGETAVRLVEELKPDLAILDVKMPVLDGLSAAERIHEQ-HLAPVLMLTAFSQRELVDRARDAGAMAYIVKPFSKSDLVPAIEMAVSRY--
+----TRIVIADDESLIRMNLRETLVGLGYLVVGEAGDGVSVINLARELRPDVVVMDIKMPKLDGIQAAKVLTEE-KIAPVLLLTAHSDKELVERARDAGVVGYLSKPFRDSDLMPALEI-------
+----TRIVIADDDHLMRAGLVELVTDPSIQVVGEAATGREAVTQTQRLRPDVVLMDVRMPDLDGIAATRELATRVPETRVLILTTFEQDDYVFGALRAGASGFLLKRTRPEDLIAAVHTVA-----
+----TRIVIADADRVFLKKLKDSLTHVGYMVVGEVYDAKSALQVIFKTEPDLIIMDSNIPGCEGLEIARVIEEH-RVAPVLLLTAYSQRELIEEAKHSWVFGYLLKPINQENLFPAIEIAIA----
+--TRITVLLADDNLIVREGVRALLSQADISVIGVAADHDELVRAAGRLRPEVVVTDIRMPTDEGVRAAQLIRAANPATGIVLLSQYDEPDYAIALLRDGASGYLLKEADPDLLARAIREVA-----
+----TRITIVEDQTILLDSLASAIDEDDFTVVDKLTDAAAIHASVRIHPVDLVLMDVVTENSSGLSESTKLKRDHPNLKVVIFTAMPDAAFLQEAHEAGVDSFVYKNISTPDLLAVLRSTMQ----
+----TRITIVEDQTILLDSLASAIDEDDFTVVDKLTDAAAIHASVRIHPVDIVLMDVVTENSSGLSESTKLKRDHPNLKVVIFTAMPDAAFLQEAHEAGVDSFVYKNISTPDLLAVLRSTMQ----
+--TRIRVVVAEDQLAVRAGLVLILRSADIEVVAEAADGEQAVRLARELRPDLVLMDIQMPRLDGVSATREIAAE-QLADVLILTTFDLDEYVFGALRAGAAGFLLKDSDAAGLLAAVRTVAS----
+--TRIRILCVDDHPIVRDGIAYALQQNDMELVAEATNGHEAIEAFRKHKPDVTLMDLQMPGMSGIEATAEIRKEFPQARIVILTTYSGDIQASRALKLGAVGYLLKGMLRTELVDTIRRVYA----
+----TRINLVEDEKNLNSVLTSYLEKEGWE-VKSFKNGSDAFDEID-DSPDIWILDIMLPGIDGFELLREIRKRDSMIPVIFISARDKDIDRVVGLEMGSDDYLPKPFLPRELVIRVKKILERV--
+----TRIMLVEDEASLSEPLAFLLQREGYE-VDVVEDGPAAVASFDKDGADLILLDLMLPGLPGTEVCREIRTR-SAVPIIMLTAKDSEVDIVVGLELGADDYVTKPYSTRELLARIRAVLRRR--
+----TRIMLVEDEASLSEPLAFLLQREGYE-VDVVEDGPAAVAAFEKDGTDLILLDLMLPGLPGTEVCREIRTR-SAVPIIMLTAKDSEVDIVVGLELGADDYVTKPYSTRELLARIRAVLRRR--
+----TRIMIVEDQTMVRDALRNSLDIEDFSVIAAIADAALAELYCERTSPDLVLMDVCTEDSSGLDAAAAIKKRFPRVRVVMMTGLPEVTFVERAREAGADSFVYKDLDVNGLAGVIRDTCA----
+----TRIMIIEDEPLIAMDIEQMVESLGHEVVGIARTRDEALALYRQEKPRMVLADIQLAGSSGIDAVNEILQN-DAIPVIFITAFP--ERLLTGERPEPTFLVTKPFNPDMVKALISQAL-----
+----TRIMIIEDEPLIAMDIEQMVESLGHEVVGIARTKDEALALYKQEKPRMVLADIQLAGSSGIDAVNEILQN-DTIPVIFITAFP--ERLLTGERPEPTFLVTKPFNPDMVKALISQAL-----
+----TRILYIEDDEALGRLLQKRFRRHSLE-VDLAVTAEVGLEVIAQREFDLILLDYNLPGMNGLETLKALKAREVTTPVIILTAGGDEAIALEAMELGAADYAVKDINQAYL-------------
+----TRILVVEDNEINQEVICNLLEIVGLR-VDLASSGEQAIEMACRDRYDLILMDIQMPELDGVQATRRLRERWLSCPILAMTANVFEDERRRYLREGLDDHIPKPVDPPHLYAVLLKWLAR---
+----TRILVVEDEVSFSDPLSYLLRKEGYE-VSVAENGNDALTEFDSGGADLVLLDLMLPGLSGVDVCRALRQR-SNVPVIMLTAKDSEIDKVVGLELGADDYVTKPYSSRELLARIKAVLRRL--
+----TRILVVEDESIVAKDIQTTLQSLGYSVPAVVSSGEAAIDRAAVSDLDLVLMDIVLKEMDGVEAAEHIYGN-FNIPVIYLTAYADDHTLRRAKTTTPFGYILKPFEERELQTAIEIALYRHK-
+----TRILVVEDEPSYLDPLLYQLTREGYE-AHGAATGEEAWELYEEMEFDLVLLDLMLPGISGTTLCRRMHEL-RRVPIIMVTAKSTENDVIVGLEIGADDYVTKPYSFRELLARIHAVLRRS--
+----TRILVVEDEESYREPLTYQLTREGYD-VVAVATGTEALSAYDDEQPDLVLLDLMLPGLSGTEVCRELRSR-GDVPVIMLTAKDGEIDKVVGLELGADDYVTKPYSFRELLARMRAVLRRHT-
+----TRILVVEDEESYREPLTYQLTREGYD-VVAVADGAAGLAAYDEGGADLVLLDLMLPGLSGTEVCRELRQR-GDVPVIMLTAKDGEIDKVVGLELGADDYVTKPYSFRELLARVRAVLRRR--
+----TRILVVEDEESYRDPLTYQLAREGFD-VVAAADGLEAIEKFEADGIDIVLLDLMLPGLSGTEVCRRLRLV-SDVPVIMLTAKDTEIDKVVGLELGADDYVTKPYSFRELLARVRAVLRRR--
+----TRILVVEDEESFSDPLSYLLRREGYD-VAVTETGPEALEEFDKAGADLVLLDLMLPGLPGTEVCRQLRTR-SSVPVIMLTAKDSEIDKVVGLEIGADDYVTKPYSSRELLARVRAVLRR---
+----TRILVVEDEEMVRANIVDLLEAEGYE-TQEASDGEQALQLIWQNPPDLILCDVRMPRVDGFTFLARISQRLRAIPFIFLTARVEREDQRLGMNLGADDYITKPFTRKDLLTAVQRRLEKH--
+----TRILVVEDEEKIARFVELELRHEGYE-VDKAADGRSGVEAALSSDYDLVLLDVLLPQLNGMEVLRRLRRQ-KDTPVILLTARDAVMDKVAGLDAGADDYITKPFAIEELLARIRVTLKH---
+----TRILVVEDEDSYRDPLTYQLTREGYE-VVEASNGHDALAAFDDGGADLVLLDLMLPGLSGTEVCRELRQR-GDVPVIMLTAKDSEIDKVVGLELGADDYVTKPYSFRELLARMRAVMRRR--
+----TRILVVEDDPSIARLLQLELEHRGYE-VCCAADGEEGLAAFERLRPDVVVLDIMLPGMDGVGVLRRLREAGHRTPVIMLTARDATGDKVHSLDRGADDYLTKPFEVEELLARMRAVLRRV--
+----TRILVVDPSYSNRLYLKLTLERAGYQ-VFDAKDGKEALNQFKQFQPHLVITEIDLPLLSGESLVSEIKSEETFYPIFVVTNVTSPESIQEILEAGADDFLQKPYPEKLFLAKVASLLRNL--
+----TRILVVDDSKTIRRSAEVLLTKAGCE-VQLAEDGFEALGKVVSFKPDLVFVDIMMPRLDGYHTCALIKNQLRDTPVVMLSSKDGLFDRAKGRLVGARLYLAKPFTADELIGAVRASL-----
+----TRILVVDDSATNLRILDGQLRQMGLG-VETLSDPTRTLARLHHSPFQIAILDRYMPVLDGIELARRIRAILQRMKVVMLTSASHLGELDRVRQLGLDAFLVKPTRQLQLRQSLARVL-----
+----TRILVVDDQALVRGALAALLDEDDLQVVGQVDSGPAAVDFVRDTSVDVVLLDIEMPGGGGIDALPDLLTAPTPPRVLVVTTFGRPGYLRRALDAGASGFVVKDCPPTELLEAVRRTA-----
+----TRILVVDDHAVVRQGVKQILSEQFHGVLGDAQNAEEMILQVGKHSWDIVILDVGMPGKSGLDALKELKQARPKLPVLVLSGYPEDQLALRMLKAGAAGYLSKDSAPNELVQALRKIL-----
+----TRILVVDDHAVVRAGVHYFIDDIDMEIGGEAGTAEEAIRLIRAEDWDIVVLDIAMPDKSGVEVLKQIKREKPDLPVLILSMHPENRYAVQILRSGASGYVQKEALATELVNAIQTIMRGH--
+----TRILVVDDEPQILRALRINLTARGYE-VVTAADGRSALRAAAQQRPDVIVLDLGLPDLDGIEVLAGLHG-WCSAPVIVLSARSDAADKVAALDTGADDYVTKPFGMEEFLARIRAAVRRAA-
+----TRILVVDDEPQILRALRINLSVRGYD-VVTAASGAAALRAAAERPPDVIVLDLGLPDMDGTEVLAGLRG-WCPAPVIVLSARTDSADKVDALDAGADDYVTKPFGMDEFLARVRAAARRAT-
+----TRILVVDDEPQILRALRINLRARGYD-VEVAGSGAAALKAAAGHPPDLVVLDLGLPDLDGTDVIRGLRG-WTAVPIIVLSGRAGSEDKVAALDAGADDYVTKPFGVDELLARIRAVTRRL--
+----TRILVVDDEPQILRALRINLRARGYD-VEVADSGAAALKAAAGHPPDLVVLDLGLPDLDGTDVIRGLRG-WTAVPIIVLSGRAGSEDKVAALDAGADDYVTKPFGVDELLARIRAVTRRL--
+----TRILVVDDEPQILRALRINLKSRTYD-VETVANGVDALASAARRLPDAVLLDLGLPDMDGVEVILGLRG-WTTVPIVVLSGRTDPQEKIHALDAGADDFVTKPFAMEELLARLRAVIRRHQ-
+----TRILVVDDEPPIRTVLRGYLEAEGFV-VSEAADGAAALAELRAEPVDLVLLDVMMPGMDGLEVLRRLRTV-ADTYVILVTARSEEVDKLVGLGVGADDYVTKPFSPREVTARVKSVLRRR--
+----TRILVVDDEPKLGKVVAQMLELDGHE-VERAAGGRDALVRLAASRFDVVVTDLRMPDVDGLAVLRAARAVPQPPEVVVMTAYATAESAVEAMKAGAVDYVTKPFSMDELRLRVRRLAAQR--
+----TRILVVDDEPDMLQAMERILPREDLE-VVVRDRATAGLEVIRQPGADVLLCDIRMPEMDGLELLAAAKEIDPWLTVVMMTAYGGIETAVKAVKSGAYDFITKPFEIPDLVRVLHKALERS--
+----TRILVVDDELSMREFISILLEREGYE-VLTAADATTALTRLAASDIDLVISDVQMPGLSGLELLARIKENKPDTAVLLITAFSTAEQAVEAMKLGAYDYLAKPFKVDEIKILVKNALEKR--
+----TRILVVDDEADLEVLIKQKFRKKEYE-FFFALNGKKALEVMEEKDIDMILSDINMPEMDGLTLLSKVKEQHSLLKTVIISAYGDMDNIRTAMNLGAFDFITKPVDFQDLEITIEKTIESI--
+----TRILVVDDDTALAEMIGIMLESEHYE-PFFCADGAQALATFREVNPHLVLLDLMLPGLDGVEICRLIRAE-SDVPVIMLTARTDTQDVVAGLEAGADDYVTKPFKSKELLARVRTRLRR---
+----TRILVVDDDSEIRELLDEYLSRNGYQ-VATVADGHQLKHYLAENGPELVLLDIMLPGEDGFSLCQFMRRE-STVPIIMLTAVSEETDQIIGLEIGADDYIAKPFNPRHLVARIKAVLRRV--
+----TRILVVDDDPSIAEMLALLLESEGFE-VSVCATGNNALPLFRADRPDLVLLDVMLPGLDGVSVCRLIREE-SDVPIIMMSARTDSVDVIAGLEAGADDYVTKPFENSVLLARVKARLRRQ--
+----TRILVVDDDASLAEMIGIMLESESYT-PTLCHDGAKALDAFHEVSPDLVLLDLMLPGLDGVEICRLIRSE-SDVPIIMLTARTDTQDVVAGLEAGADDYVTKPFKSKELLARVSTRLRRT--
+----TRILVVDDDASLAEMIGIMLESESYT-PTLCHDGAKALDAFHEVNPDLVLLDLMLPGLDGVEICRLIRSE-SDVPIIMLTARTDTQDVVAGLEAGADDYVTKPFKSKELLARVSTRLRRT--
+----TRILVMDDNPEVLEAYRAIFSAQVFE-LVAVSQGQDGVAEVERRPFAVAFVDIRMPGMDGLEVARRIRALDAHIYINIVSAYSDHDEIHDQLQHDV-QFIKKPVSRGELYQMARDGCER---
+----TRILVIGNVNEHCESIESYLKPFNIQ-TKNAQDLDRASQKMMDYSPQIIFINHMVSGVSSSVIISKLKTGSKSVRFVLLKNSNTEEEGIDYQTLGFNQCINKPIKQKSLFNALRKI------
+----TRILVIEDETEIASFLRRGLSLEGYQ-VDVAFDGTRGLELASTGTYDLIVLDLMLPGIDGLEVARRLRAD-SNVPIIMLTARDAVRDRVAGLEAGADDYLVKPFAFEELLARIRAQLRRR--
+----TRILVIEDDEETASFIANGLKQEGFA-VDTAKTGTDGLFQATESPPDLVVVDRMLPGLDGVSVIKALRAAGVKIPVLFLTAMGAVEDRVAGLEAGGDDYLVKPFSFMELRARVTTLLRR---
+----TRILVIDDMPSIRDLVKNTLKAMGYKNLQEAEDGEAGLKILIQNQIQLVISDWNMPKMKGLELLKQVRAEFANLPFVLLTSESERDQVTEAVLAGVSQYIVKPFSAKIFEDKLKAAYSKH--
+----TRILVIDDEEDILALIKNTLQLQNYL-VKTFVSANQ-VDRSKLADYDLILLDIMMPDVDGLSFCRDIRNL-VDCPILFLTAKSQEADVVTGLSYGADDYICKPFGVQELLARVDAHLRRE--
+----TRILVIDDDRSFIHHMQTALRGLGE--VRVTTCGVDGLRTVEHWEPDVVMLDLLLHDVDGFTLLERLTGDCRHRPAV---------------------------------------------
+----TRILVADDHRLIAESVSLSLSSEGFD-VEISDSLSSTLEKIISEPYSIVMLDLRMPGMDGINSIKKVVDAAGDANVVLFSANADTHTVARAIEVGVRGLVPKTLPLQSLGSVLR--------
+----TRILVADDHPLFREALSGALGPYNAQ-ILEAGSLDAALAVLNEDGIELVLLDLNMPGGEYFNGIITLREQYPNIPIGVVSGSDAVEVVAQVMSLGAQGFIPKVSATREMAQAIVDII-----
+----TRILVADDHPLFREALSGALEPYNAQ-IIQAGSLDDAMAKLNEDGVELILLDLNMPGGEYFNGLITLREQYPNIPVGVVSGSDTVEVVAQVMSLGAQGFIPKVSQTREIAQAIVDII-----
+----TRILVADDHPLFREALSGALEPYNAQ-IIQAGSLDDALEKLNEDGVELVLLDLNMPGGEYFNGLITLREQYPNIPIGVVSGSDTVEVVAQVMSLGAQGFIPKVSETREIAQAIVDII-----
+----TRILVADDHDLVRMGIVRMLQDEGFEVVGEAKTGEQAIALSRELQPQVVLMDVKMPGIGGLEATRKILASCSHTRVVAVTAVSDDLFPERLMKAGASGYVTKGAGFDEIIDAVHSVMN----
+----TRILVADDHAIFREGLKQVIGTVDMSVVDEAVDGKELLNKIQANDYDMVILDITMPGRNGLDVLTEMKSIKPKLPVLVMSMHPEEQYALRAYKSGAAGYLNKGSASNELLDALHKI------
+----TRILVADDEHLIRNAIAGLLEEDGFEVVGQAASGDEALATALRVRPDVALLDLQLPGPDGIEVARRLAAQLPECRSIIVTSHARPGYLKSALAAGARGFLPKTVSPRTLAQVVRTVV-----
+----TRILVADDEHLIRDAVAGLLDEEDFEVVAQAASGDEALAMALKLRPDVALLDLQLPGPDGIEIARRLATELPGCRCVIVTSHGRPGYLKSALAAGVSGFLPKTVSSRTFAEVVRKVA-----
+----TRILVADDEESMRWVLSKALKRKGFT-VDLADDGRQALALIQENSYDLAILDIKMPGMSGLDLLDRIREMKSDLLVVIMTAEASMKNAVEAMKRGAYDYITKPFDLDVIDAIVEKVGR----
+----TRILTIEDDAVTAREIVAELSSHGLD-VDWVDNGREGLVRAVSGDYDLITLDRMLPELDGLAIVTTLRTIGVSTPILMISALSDVDERVRGLRAGGDDYLTKPFASDEMAARVEVLLRRKS-
+----TRILTIEDDAVTAREIVAELSSHGLD-VDWVDNGREGLVRAVSGDYDLITLDRMLPELDGLAIVTTLRTIGVSTPILMISALSDVDERVRGLRAGGDDYLTKPFASDEMAARVEVLLRRKN-
+----TRILTIEDDAVTAREIVAELSSHGLD-VDWVDNGREGLDRAVSGNYDLITLDRMLPELDGLAIVTTLRTMGVATPILMISALSDVDERVRGLRAGGDDYLTKPFATDEMAARVEVLLRRQN-
+----TRILQVEDDIISQRFMNQLCKIAGWK-IKIASNGLEALNILENEDFDIILMDIQMPDMSGIELTKIIRETGKHITIIAMTAYAMGGDRDICINTGMDDYISKPIEVMKLKEVITKYSS----
+----TRILMIEDDMELAEILTEYLENYDIK-VTTAEEPYIGLSTLNTSEFDLVILDLTLPGMDGLEVCKEIRKK-HNIPIIISSARHDITDKVNALDNGADDYLPKPYDPQELLARIKSHLRRQS-
+----TRILLYSDEPILAKGLESVLRQEGFDLLPTCNTLAALMEQITQGTPDLVLMDLTPEV--TFAVLSEMKHAMNNSRIVLWVNSISTELAFQAMGLGVRGILRKTLPTELQVKCLQKV------
+----TRILLVHEIPLWRVALRALLTGTDLH-VDTAGPGDVGR-AAGTCPPDVYVLDLDCPGLTEIETFRASRDTADTGALVILTKGERPGDLRRAFHAGAGGYVDKYGETGDLAAVVRKVA-----
+----TRILLVEDNEMNRDMLSRRLSRRGFE-VLIAENGQAGVELAASEKPDLILMDMSLPVMDGWEATRRIKALTSAIPVIALTAHAMASDREMALKAGCDDYDSKPVDLPQLVRKIEQLLT----
+----TRILLVEDNEMNRDMLSRRLSRRGFD-VLIAENGKDGVEIAASERPDLILMDMSLPVMDGWEATRQIKANTCGIPVIALTAHAMASDRDMALDAGCDDYDSKPIDLPQLVRKIEQLLT----
+----TRILLVEDNEINQQVARAILEEVGLV-CDLAENGEEAVAMIGKARYALALMDMQMPRMDGVTATQAIRQLGKDIPIVAMTANAFNDDVQRCLASGMNDFLLKPVDPDKLYDTLLKW------
+----TRILLVEDEESYREPLTYQLEREGYE-VVAAADGLQAIELFEEHGADLVLLDLMLPGLPGTEVCRRLRLT-SDVPVIMLTAKDDEIDKVVGLELGADDYVTKPYSSRELLARMRAVLRRR--
+----TRILLVEDEESYRDPLSYQLGREGYD-VVTAATGPEALERFAEHGADLVLLDLMLPGLPGTEVCRRLRL-DSDVPVIMLTAKDDEIDKVVGLELGADDYVTKPYSSRELLARIRAVLRRR--
+----TRILLVEDEESISDPLAYLLGKEGYD-VTVAADGLQALAEFDSHGADLVLLDLMLPGASGTEVCRQLRAK-SKVPIIMLTAKDSEIDKVVGLELGADDYVTKPYSSRELLARIRAVMRRN--
+----TRILLVEDEENYREPLAFNLRRDGYD-VVEAEDGAVAVELFEEEPIDLVLLDLMLPRLSGTEVCRRIRRS-SNVPVIMLTAKDSEVDKIVGLEIGADDYVTKPYSYRELVARVHAVLRRT--
+----TRILLVEDEENFRDPLAYGLRRDGFE-VVEAEDGQRAVEIFEASRIDLVLLDLMLPRLDGTGVCTRIRRS-SSVPVIMLTAKDTELDKIVGLEIGADDYVTKPYSYRELLARLKAVLRRS--
+----TRILLVEDEENFRDPLAYGLRRDGFE-VVEAEDGQRAVEIFEASRIDLVLLDLMLPRLDGTEVCTRIRRS-SSVPVIMLTAKDTELDKIVGLEIGADDYVTKPYSYRELLARLKAVLRRS--
+----TRILLVEDEENFRDPLAFSLRRDGFE-VIEAEDGQRAVEIFETSRIDLVLLDLMLPRLDGTEVCTRIRRS-SSVPVIMLSAKDTELDKIVGLEIGADDYVTKPYSYRELLARLKAVLRRS--
+----TRILLVEDEDSFSDPLSYLLGKEGYE-VTVADDGLKALAEFDRNGADLVLLDLMLPGVSGTEVCRELRVK-SSVPIIMLTAKDSEIDKVVGLELGADDYVTKPYSSRELLARVRAVLRRN--
+----TRILLVEDDPLIVDSLTELLAGSGYS-VDTADTQQRAIELAVDHPYQLILLDVTLRQGNGFAVCAAVKEATPDVPVIFLTASDDEFNTVTGLTMGADDYVAKPFRPRELLARIAATIRRS--
+----TRILLVEDDPLIVDALTELLTSSGYS-VDTADTQTRAIELATGGTYQLVLLDVTLREGNGFAVCAAVKETSPSTPVIFLTASDDEFNTVTGLTMGADDYVAKPFRPRELLARIAATIRRS--
+----TRILLVEDDLLLSEGISYALRKESYL-VDCADSIEKAWECLNK-GPSLVLLDVNLPDGDGREFLKRLRSA-NKVPVVFLTARDSEKDMLEGFDAGCDDYITKPFPISVLSRKIGLLLK----
+----TRILLVEDDEVMPKIMERILHKEEYK-IEHVTNGKEAFQRLEDNNYDLIITDIMMPYANGFEILSKVKTRGKPIPVIIVSNAGNEEMILEGFKLGADDFLKKPVIPGELLIRVKRLLIQ---
+----TRILLVEDDERLAELTAEYLTKNDLE-VSIEPRGDTAEARILAEQPDLVILDVMLPGKDGFEVCRAVRSQF-RGVILMLTARDEDFDQILGLEMGADDYIAKPVQPRVLLARIKALLRRL--
+----TRILLVEDDAGMQRIVSDHFADHDVA-VTAATDRAEAEKRLAEAEFDLVVLDLRLGSENGLDLLRDLRAR-SDLPVIITTGHRRDEDRVIGLELGADDYLVKPYGLRELLARVRVILRRAE-
+----TRILLVDDQPQFRRAAAALIGTAGLRLVGQAGSGEEAVELADRLRPDLIVMDVRLPGIDGTEACRRIRHRRPDIRVILVSTYER-ADLPGIDDCGATRFVRKQ-------------------
+----TRILLVDDHTIFRSGLRRLISKPEYCVAAEASNSAEALSLVRDQDFDVVILDINLNGRSGLEVLESIRRTKPNLRVLVMSMYPEAQFGAEAVRLGANGYLSKDTTPDALFDALRSAAQ----
+----TRILLVDDEAPIRRAVRRFLEHHGFQ-VRLAEDLASARAALREELPDLMLVDLRLPDGEGIELLAEAG----HTPTVIMTSYASVPSAVTAMKEGAADYIAKPFDHDALLLTLRAALR----
+----TRILLVDDDPTILDAFPVYFSTDDLEISGTARTGRQALTWLDTNTCDLVLSDVQMPDIDGIELLQHIRDLNRPPLFVAMTAFDTDDTMLKCLSLGAVGYIIKGRAPESIIHSLRDAT-----
+----TRILLVDDDAPLLRALRINLTARRYE-VTTATDGTTALTLAARTPPDLAIVDLGLPDLDGVTVVEGLRG-WTRIPIIVLSARDTESAKVDALDAGADDYITKPFGMNELLARIRAALRRA--
+----TRILLVDDAQIECLAFERQLHKIPFHQLDWVSTYADALVAFDRDQHDLYFVDFRLGPDNGLDLVRRARVNGMTKPIIVLTGHGSAAVDKAATDAGANDYLVKEFDAVLLERSIRYASRN---
diff --git a/setup.py b/setup.py
new file mode 100755
index 0000000..6bf26b9
--- /dev/null
+++ b/setup.py
@@ -0,0 +1,36 @@
+#!/usr/bin/python
+# FreeContact - program to predict protein residue contacts from a sufficiently large multiple alignment
+# Copyright (C) 2013 by Laszlo Kajan, Technical University of Munich, Germany
+#
+# This program is free software: you can redistribute it and/or modify
+# it under the terms of the GNU General Public License as published by
+# the Free Software Foundation, either version 3 of the License, or
+# (at your option) any later version.
+#
+# This program is distributed in the hope that it will be useful,
+# but WITHOUT ANY WARRANTY; without even the implied warranty of
+# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
+# GNU General Public License for more details.
+#
+# You should have received a copy of the GNU General Public License
+# along with this program. If not, see <http://www.gnu.org/licenses/>.
+#
+from distutils.core import setup, Extension
+from glob import glob
+
+setup( name = 'python-freecontact',
+ version = '1.0',
+ author = 'Laszlo Kajan',
+ author_email = 'lkajan at rostlab.org',
+ description = 'fast protein contact predictor',
+ #long_description = '',
+ #download_url = '',
+ license = 'GPL-3+',
+ url = 'http://rostlab.org/',
+ ext_modules = [Extension(
+ name = 'freecontact',
+ sources = glob('src/*.cpp'),
+ libraries = ['freecontact', 'boost_python'])]
+ )
+
+# vim:et:ts=4:ai:
diff --git a/src/freecontact.cpp b/src/freecontact.cpp
new file mode 100644
index 0000000..6a517f5
--- /dev/null
+++ b/src/freecontact.cpp
@@ -0,0 +1,364 @@
+/* FreeContact - program to predict protein residue contacts from a sufficiently large multiple alignment
+* Copyright (C) 2013 by Laszlo Kajan, Technical University of Munich, Germany
+*
+* This program is free software: you can redistribute it and/or modify
+* it under the terms of the GNU General Public License as published by
+* the Free Software Foundation, either version 3 of the License, or
+* (at your option) any later version.
+*
+* This program is distributed in the hope that it will be useful,
+* but WITHOUT ANY WARRANTY; without even the implied warranty of
+* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
+* GNU General Public License for more details.
+*
+* You should have received a copy of the GNU General Public License
+* along with this program. If not, see <http://www.gnu.org/licenses/>.
+*/
+#include <boost/python.hpp>
+#include <boost/python/raw_function.hpp>
+#include <freecontact.h>
+
+namespace bp = boost::python;
+namespace fc = freecontact;
+
+typedef freecontact::predictor::cont_res_t cont_res_t;
+typedef freecontact::predictor::time_res_t time_res_t;
+typedef freecontact::predictor::freq_vec_t freq_vec_t;
+
+char const* greet(int hel, int word) { return "hello, world"; }
+
+bp::dict _get_ps(const fc::parset_t& __ps)
+{
+ bp::dict d;
+ d["clustpc"] = __ps.clustpc;
+ d["density"] = __ps.density;
+ d["gapth"] = __ps.gapth;
+ d["mincontsep"] = __ps.mincontsep;
+
+ d["pseudocnt"] = __ps.pseudocnt;
+ d["pscnt_weight"] = __ps.pscnt_weight;
+ d["estimate_ivcov"] = __ps.estimate_ivcov;
+ d["shrink_lambda"] = __ps.shrink_lambda;
+
+ d["cov20"] = __ps.cov20;
+ d["apply_gapth"] = __ps.apply_gapth;
+ d["rho"] = __ps.rho;
+ return d;
+}
+
+bp::dict get_ps_evfold() { return _get_ps(fc::ps_evfold); }
+bp::dict get_ps_psicov() { return _get_ps(fc::ps_psicov); }
+bp::dict get_ps_psicov_sd() { return _get_ps(fc::ps_psicov_sd); }
+
+class __attribute__ ((visibility ("hidden"))) py_predictor : public fc::predictor {
+ public:
+ py_predictor(bool __dbg = false) : fc::predictor(__dbg){}
+
+ bp::dict py_get_seq_weights(const bp::list& __ali, double __clustpc,
+ bool __veczw, int __num_threads);
+
+/* bp::dict py_run_with_seq_weights(const bp::list& __ali, const bp::list& __aliw, double __wtot,
+ bp::dict& __timing,
+ double __density, double __gapth, uint16_t __mincontsep,
+ double __pseudocnt, double __pscnt_weight, bool __estimate_ivcov, double __shrink_lambda,
+ bool __cov20, bool __apply_gapth, double __rho,
+ int __num_threads, time_t __icme_timeout)*/
+};
+
+fc::ali_t input_t_ali(const bp::list& __ali)
+{
+ size_t seqcnt = bp::len(__ali);
+ if(!seqcnt) return fc::ali_t();
+
+ // alilen
+ fc::ali_t ali(bp::len(__ali[0])); for(size_t i = 0, i_e = seqcnt; i < i_e; ++i) ali.push(bp::extract<std::string>(__ali[i]));
+ return ali;
+}
+
+bp::dict py_predictor::py_get_seq_weights(const bp::list& __ali, double __clustpc,
+ bool __veczw, int __num_threads)
+{
+ freq_vec_t aliw; double wtot = 0;
+ bp::list aliw_list;
+ size_t seqcnt = bp::len(__ali);
+ if(seqcnt)
+ {
+ fc::ali_t ali = input_t_ali(__ali);
+ get_seq_weights(aliw, wtot, ali, __clustpc, __veczw, __num_threads);
+
+ for(size_t i = 0, i_e = aliw.size(); i < i_e; ++i) aliw_list.append(aliw[i]);
+ }
+ bp::dict aliw_wtot;
+ aliw_wtot["aliw"] = aliw_list;
+ aliw_wtot["wtot"] = wtot;
+ return aliw_wtot;
+}
+
+void translate_runtime_error(const std::runtime_error& __e)
+{
+ PyErr_SetString(PyExc_RuntimeError, __e.what());
+}
+
+freq_vec_t input_freq_vec_t(const bp::list& __aliw)
+{
+ freq_vec_t aliw(len(__aliw));
+ for(size_t i = 0, i_e = len(__aliw); i < i_e; ++i) aliw[i] = bp::extract<freq_vec_t::value_type>(__aliw[i]);
+ return aliw;
+}
+
+bp::dict output_cont_res_t(const cont_res_t& __cont_res)
+{
+ if(__cont_res.empty()) return bp::dict();
+ else
+ {
+ // return { 'l1norm' => [ [ 0, 1, 45.786 ], [ 0, 2, 7.993 ], ... ], ... }
+ bp::dict res;
+ for(cont_res_t::const_iterator cr_i = __cont_res.begin(), cr_e = __cont_res.end(); cr_i != cr_e; ++cr_i)
+ {
+ bp::list contacts;
+ for(std::vector<fc::contact_t>::const_iterator ct_i = cr_i->second.begin(), ct_e = cr_i->second.end(); ct_i != ct_e; ++ct_i)
+ {
+ bp::list ijscore;
+
+ ijscore.append(ct_i->i);
+ ijscore.append(ct_i->j);
+ ijscore.append(ct_i->score);
+ //
+ contacts.append(ijscore);
+ }
+ res[cr_i->first] = contacts;
+ }
+ return res;
+ }
+}
+
+void output_time_res_t(const time_res_t* __p_timing, bp::dict __py_timing)
+{
+ if(__p_timing)
+ for(time_res_t::const_iterator tr_i = __p_timing->begin(), tr_e = __p_timing->end(); tr_i != tr_e; ++tr_i)
+ __py_timing[tr_i->first] = tr_i->second;
+}
+
+void input_parset_t(bp::dict& __kw, fc::parset_t& __ps)
+{
+ if(__kw.has_key("clustpc")) __ps.clustpc = bp::extract<double>(__kw["clustpc"]);
+
+ if(__kw.has_key("density")) __ps.density = bp::extract<double>(__kw["density"]);
+ if(__kw.has_key("gapth")) __ps.gapth = bp::extract<double>(__kw["gapth"]);
+ if(__kw.has_key("mincontsep")) __ps.mincontsep = bp::extract<uint16_t>(__kw["mincontsep"]);
+
+ if(__kw.has_key("pseudocnt")) __ps.pseudocnt = bp::extract<double>(__kw["pseudocnt"]);
+ if(__kw.has_key("pscnt_weight")) __ps.pscnt_weight = bp::extract<double>(__kw["pscnt_weight"]);
+ if(__kw.has_key("estimate_ivcov")) __ps.estimate_ivcov = bp::extract<bool>(__kw["estimate_ivcov"]);
+ if(__kw.has_key("shrink_lambda")) __ps.shrink_lambda = bp::extract<double>(__kw["shrink_lambda"]);
+
+ if(__kw.has_key("cov20")) __ps.cov20 = bp::extract<bool>(__kw["cov20"]);
+ if(__kw.has_key("apply_gapth")) __ps.apply_gapth = bp::extract<bool>(__kw["apply_gapth"]);
+ if(__kw.has_key("rho")) __ps.rho = bp::extract<double>(__kw["rho"]);
+}
+
+bp::dict py_run(bp::tuple __args, bp::dict __kw)
+{
+ py_predictor& self = bp::extract<py_predictor&>(__args[0])();
+
+ if(!__kw.has_key("ali")) throw std::runtime_error("required argument 'ali' is missing");
+ if(!bp::extract<bp::list>(__kw["ali"]).check()) throw std::runtime_error("argument 'ali' is not a list");
+
+ const bp::list& py_ali = bp::extract<bp::list>(__kw["ali"]);
+ size_t seqcnt = bp::len(py_ali);
+ if(seqcnt)
+ {
+ time_res_t timing, *p_timing = NULL;
+ fc::parset_t ps = fc::ps_evfold;
+
+ fc::ali_t ali = input_t_ali(py_ali);
+ input_parset_t(__kw, ps);
+ if(__kw.has_key("timing") && bp::extract<bp::dict>(__kw["timing"]).check()) p_timing = &timing;
+
+ cont_res_t cont_res = self.run(
+ ali,
+ ps.clustpc,
+ ps.density, ps.gapth, ps.mincontsep,
+ ps.pseudocnt, ps.pscnt_weight, ps.estimate_ivcov, ps.shrink_lambda,
+ ps.cov20, ps.apply_gapth, ps.rho,
+ __kw.has_key("veczw") ? bp::extract<bool>(__kw["veczw"])() : true, __kw.has_key("num_threads") ? bp::extract<int>(__kw["num_threads"])() : 0, __kw.has_key("icme_timeout") ? bp::extract<time_t>(__kw["icme_timeout"])() : 1800, p_timing
+ );
+
+ if(p_timing) output_time_res_t(p_timing, bp::extract<bp::dict>(__kw["timing"]));
+
+ return output_cont_res_t(cont_res);
+ }
+ else return bp::dict();
+}
+
+bp::dict py_run_with_seq_weights(bp::tuple __args, bp::dict __kw)
+{
+ py_predictor& self = bp::extract<py_predictor&>(__args[0])();
+
+ if(!__kw.has_key("ali")) throw std::runtime_error("required argument 'ali' is missing");
+ if(!bp::extract<bp::list>(__kw["ali"]).check()) throw std::runtime_error("argument 'ali' is not a list");
+
+ const bp::list& py_ali = bp::extract<bp::list>(__kw["ali"]);
+ size_t seqcnt = bp::len(py_ali);
+ if(seqcnt)
+ {
+ time_res_t timing, *p_timing = NULL;
+ fc::parset_t ps = fc::ps_evfold;
+
+ fc::ali_t ali = input_t_ali(py_ali);
+ input_parset_t(__kw, ps);
+ if(__kw.has_key("timing") && bp::extract<bp::dict>(__kw["timing"]).check()) p_timing = &timing;
+
+ if(!__kw.has_key("aliw")) throw std::runtime_error("required argument 'aliw' is missing");
+ if(!bp::extract<bp::list>(__kw["aliw"]).check()) throw std::runtime_error("argument 'aliw' is not a list");
+ if(!__kw.has_key("wtot")) throw std::runtime_error("required argument 'wtot' is missing");
+
+ freq_vec_t aliw = input_freq_vec_t(bp::extract<bp::list>(__kw["aliw"]));
+
+ cont_res_t cont_res = self.run(
+ ali,
+ aliw, bp::extract<double>(__kw["wtot"]),
+ ps.density, ps.gapth, ps.mincontsep,
+ ps.pseudocnt, ps.pscnt_weight, ps.estimate_ivcov, ps.shrink_lambda,
+ ps.cov20, ps.apply_gapth, ps.rho,
+ __kw.has_key("num_threads") ? bp::extract<int>(__kw["num_threads"])() : 0, __kw.has_key("icme_timeout") ? bp::extract<time_t>(__kw["icme_timeout"])() : 1800, p_timing
+ );
+
+ if(p_timing) output_time_res_t(p_timing, bp::extract<bp::dict>(__kw["timing"]));
+
+ return output_cont_res_t(cont_res);
+ }
+ else return bp::dict();
+}
+
+BOOST_PYTHON_MODULE(freecontact)
+{
+ using namespace boost::python;
+ register_exception_translator<std::runtime_error>(&translate_runtime_error);
+
+ // http://www.boost.org/doc/libs/1_49_0/libs/python/doc
+ // http://www.boost.org/doc/libs/1_49_0/libs/python/doc/tutorial
+ def("get_ps_evfold", get_ps_evfold,
+"Get parameters for EVfold-mfDCA operating mode."
+ );
+ def("get_ps_psicov", get_ps_psicov,
+"Get parameters for PSICOV 'improved results' operating mode."
+ );
+ def("get_ps_psicov_sd", get_ps_psicov_sd,
+"Get parameters for PSICOV 'sensible default' operating mode. This is much faster than 'improved results' for a "
+"slight loss of precision.\n"
+"\n"
+"These get_ps_() functions return a dictionary of arguments {'clustpc': num,...,'rho': num} that can be used "
+"with get_seq_weights(), run() or run_with_seq_weights(). The arguments correspond to the published parametrization of the "
+"respective method."
+ );
+
+ class_<py_predictor>("Predictor", init<optional<bool> >(arg("dbg")))
+ .def_readwrite("dbg", &py_predictor::dbg)
+ .def("get_seq_weights", &py_predictor::py_get_seq_weights,
+ (arg("ali"), arg("clustpc") = fc::ps_evfold.clustpc,
+ arg("veczw") = true, arg("num_threads") = 0),
+"Defaults for the arguments are obtained with get_ps_evfold()."
+ )
+ .def("run", raw_function(py_run, 1),
+"run(ali = [], clustpc = dbl, "
+"density = dbl, gapth = dbl, mincontsep = uint, "
+"pseudocnt = dbl, pscnt_weight = dbl, estimate_ivcov = bool, shrink_lambda = dbl, "
+"cov20 = bool, apply_gapth = bool, rho = dbl, "
+"[veczw = bool], [num_threads = int], [icme_timeout = int], [timing = {}])\n"
+"\n"
+"Defaults for the arguments are obtained with get_ps_evfold().\n"
+"\n"
+"ali\n"
+" List holding alignment rows as strings. The first "
+"row must hold the query, with no gaps.\n"
+"\n"
+"clustpc\n"
+" BLOSUM-style clustering similarity threshold [0-1].\n"
+"\n"
+"icme_timeout\n"
+" Inverse covariance matrix estimation timeout in seconds. Default: 1800.\n"
+"\n"
+" The estimation sometimes gets stuck. If the timeout is reached, the run() "
+"method raises a RuntimeError exception with \"inverse covariance matrix estimation exceeded time limit ...\". You can catch "
+"this exception and handle it as needed, e.g. by setting a higher rho value.\n"
+"\n"
+"num_threads\n"
+"\n"
+" Number of OpenMP threads to use. If unset, all CPUs are used.\n"
+"\n"
+"timing\n"
+"\n"
+"If given, this dictionary is filled with data containing wall clock "
+"timing results in seconds:\n"
+"\n"
+" {\n"
+" 'num_threads': NUM,\n"
+" 'seqw': NUM,\n"
+" 'pairfreq': NUM,\n"
+" 'shrink': NUM,\n"
+" 'inv': NUM,\n"
+" 'all': NUM\n"
+" }\n"
+"\n"
+"run() returns a dictionary of contact prediction results:\n"
+"\n"
+" {\n"
+" 'fro': [ # identifier of scoring scheme\n"
+" [\n"
+" I, # 0-based index of amino acid i\n"
+" J, # 0-based index of amino acid j\n"
+" SCORE # contact score\n"
+" ], ...\n"
+" ],\n"
+" 'MI': ...,\n"
+" 'l1norm': ...\n"
+" }\n"
+" \n"
+"Use 'fro' scores with EVfold."
+ )
+ .def("run_with_seq_weights", raw_function(py_run_with_seq_weights, 1))
+ ;
+
+ // set the docstring of the current module scope http://wiki.python.org/moin/boost.python/module
+ scope().attr("__doc__") = "fast protein contact predictor\n"
+"\n"
+"FreeContact is a protein residue contact predictor optimized for speed. "
+"Its input is a multiple sequence alignment. FreeContact can function as an "
+"accelerated drop-in for the published contact predictors "
+"EVfold-mfDCA of DS. Marks (2011) and "
+"PSICOV of D. Jones (2011). "
+"FreeContact is accelerated by a combination of vector instructions, multiple "
+"threads, and faster implementation of key parts. "
+"Depending on the alignment, 10-fold or higher speedups are possible.\n"
+"\n"
+"A sufficiently large alignment is required for meaningful results. "
+"As a minimum, an alignment with an effective (after-weighting) sequence count "
+"bigger than the length of the query sequence should be used. Alignments with "
+"tens of thousands of (effective) sequences are considered good input.\n"
+"\n"
+"jackhmmer(1) from the hmmer package, or hhblits(1) from hhsuite "
+"can be used to generate the alignments, for example.\n"
+"\n"
+"SYNOPSIS\n"
+"========\n"
+"import freecontact\n"
+"\n"
+"EXAMPLE = open('/mnt/home/lkajan/project/rostlab/python-freecontact/examples/demo_1000.aln', 'r')\n"
+"aln = EXAMPLE.readlines(); aln = map(lambda s: s.rstrip(), aln)\n"
+"EXAMPLE.close()\n"
+"\n"
+"contacts = freecontact.Predictor().run(ali = aln)\n"
+"\n"
+"predictor = freecontact.Predictor()\n"
+"parset = freecontact.get_ps_evfold()\n"
+"parset.update({'ali': aln, 'num_threads': 1})\n"
+"contacts = predictor.run(**parset)\n"
+"\n"
+"predictor = freecontact.Predictor()\n"
+"aliw_wtot = predictor.get_seq_weights(ali = aln, num_threads = 1)\n"
+"contacts = predictor.run_with_seq_weights(ali = aln, aliw = aliw_wtot['aliw'], wtot = aliw_wtot['wtot'], num_threads = 1)"
+;
+}
+
+// vim:et:ts=4:ai:
diff --git a/test/test01.py b/test/test01.py
new file mode 100755
index 0000000..9dad5a7
--- /dev/null
+++ b/test/test01.py
@@ -0,0 +1,88 @@
+#!/usr/bin/python
+# FreeContact - program to predict protein residue contacts from a sufficiently large multiple alignment
+# Copyright (C) 2013 by Laszlo Kajan, Technical University of Munich, Germany
+#
+# This program is free software: you can redistribute it and/or modify
+# it under the terms of the GNU General Public License as published by
+# the Free Software Foundation, either version 3 of the License, or
+# (at your option) any later version.
+#
+# This program is distributed in the hope that it will be useful,
+# but WITHOUT ANY WARRANTY; without even the implied warranty of
+# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
+# GNU General Public License for more details.
+#
+# You should have received a copy of the GNU General Public License
+# along with this program. If not, see <http://www.gnu.org/licenses/>.
+#
+import unittest
+from test import test_support
+
+class MyTestCase1(unittest.TestCase):
+
+ # Only use setUp() and tearDown() if necessary
+
+ def setUp(self):
+ self.fc = test_support.import_module('freecontact')
+
+ def tearDown(self):
+ pass # ... code to execute to clean up after tests ...
+
+ def test1(self):
+ ps = self.fc.get_ps_evfold()
+ assert ps['clustpc'] == 0.7
+ ps = self.fc.get_ps_psicov()
+ assert ps['clustpc'] == 0.62
+ self.fc.get_ps_psicov_sd()
+
+ def test2(self):
+ fcp = self.fc.Predictor()
+ assert fcp.dbg == False
+ fcp = self.fc.Predictor(dbg = True)
+ assert fcp.dbg == True
+
+ def test3(self):
+ EXAMPLE = open('examples/demo_1000.aln', 'r')
+ aln = EXAMPLE.readlines(); aln = map(lambda s: s.rstrip(), aln)
+ EXAMPLE.close()
+
+ num_threads = 1
+ evfold_24_42 = 0.0129471030086279 # 0-based indices
+ prec_threshold = 5e-5
+ timing = {}
+
+ fcp = self.fc.Predictor(dbg = True)
+
+ # run with timing test
+ res = fcp.run(ali = aln, num_threads = num_threads, timing = timing)
+ assert abs(res['fro'][2741][2] - evfold_24_42) / evfold_24_42 < prec_threshold # 25 K 43 N 0.230969 0.0129471
+ assert timing['num_threads'] == num_threads
+
+ # run psicov with icme_timeout exception test
+ try:
+ args = self.fc.get_ps_psicov(); args.update({'ali': aln, 'num_threads': num_threads, 'icme_timeout': 2, 'timing': None})
+ fcp.run(**args) # this is expected to fail
+ assert False # fail if fell through
+ except RuntimeError as e:
+ assert e.args[0] == 'inverse covariance matrix estimation exceeded time limit (2 sec)'
+
+ # get_seq_weights test
+ aliw_wtot = fcp.get_seq_weights(ali = aln, num_threads = num_threads)
+
+ assert len(aliw_wtot['aliw']) == 1000
+ assert abs(aliw_wtot['wtot']-620.777)/620.777 < 1e-6
+
+ # run_with_seq_weights test
+ args = aliw_wtot; args.update({'ali': aln, 'num_threads': num_threads})
+ res = fcp.run_with_seq_weights(**args)
+
+ assert abs(res['fro'][2741][2] - evfold_24_42) / evfold_24_42 < prec_threshold
+
+def test_main():
+ test_support.run_unittest(MyTestCase1
+ )
+
+if __name__ == '__main__':
+ test_main()
+
+# vim:et:ts=4:ai:
--
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