[med-svn] [nanocall] 01/02: Imported Upstream version 0.6.14
Andreas Tille
tille at debian.org
Tue Sep 13 13:25:16 UTC 2016
This is an automated email from the git hooks/post-receive script.
tille pushed a commit to branch master
in repository nanocall.
commit 7410164392b788c3467ac8b6184ed05807d45930
Author: Andreas Tille <tille at debian.org>
Date: Tue Sep 13 15:18:56 2016 +0200
Imported Upstream version 0.6.14
---
.VERSION.in | 1 +
.gitignore | 2 +
.gitmodules | 9 +
.travis.yml | 15 +
.version_files | 1 +
Dockerfile | 30 +
Dockerfile.slim.in | 19 +
HACKING.org | 21 +
LICENSE | 22 +
README.org | 94 +
VERSION | 1 +
context/nanocall/.gitignore | 2 +
script/build-slim-docker-image | 33 +
script/get-lddtree | 15 +
src/.gitignore | 1 +
src/CMakeLists.txt | 184 +
src/Makefile | 35 +
src/builtin_models/.gitignore | 1 +
src/builtin_models/builtin_model_init_lists.inl | 49165 +++++++++++++++++++
src/builtin_models/builtin_model_names.inl | 13 +
src/builtin_models/builtin_model_num.inl | 1 +
src/builtin_models/builtin_model_strands.inl | 13 +
src/builtin_models/make-builtin-model-initializers | 73 +
src/builtin_models/r73.c.p1.006.ont.model | 4096 ++
src/builtin_models/r73.c.p2.006.ont.model | 4096 ++
src/builtin_models/r73.t.006.ont.model | 4096 ++
src/cmake/FindHDF5.cmake | 52 +
src/get-dir-version | 112 +
src/nanocall/Builtin_Model.cpp | 17 +
src/nanocall/Builtin_Model.hpp | 15 +
src/nanocall/CMakeLists.txt | 28 +
src/nanocall/Event.hpp | 96 +
src/nanocall/Fast5_Summary.hpp | 732 +
src/nanocall/Forward_Backward.hpp | 156 +
src/nanocall/Forward_Backward_Custom.hpp | 163 +
src/nanocall/Kmer.hpp | 151 +
src/nanocall/Parameter_Trainer.hpp | 570 +
src/nanocall/Pore_Model.hpp | 319 +
src/nanocall/State_Transitions.hpp | 258 +
src/nanocall/Viterbi.hpp | 154 +
src/nanocall/compute-scaled-pore-model.cpp | 51 +
src/nanocall/compute-state-transitions.cpp | 56 +
src/nanocall/fs_support.hpp | 38 +
src/nanocall/global_assert.hpp | 61 +
src/nanocall/list-directory.cpp | 27 +
src/nanocall/nanocall.cpp | 1041 +
src/nanocall/run-fwbw.cpp | 101 +
src/nanocall/run-viterbi.cpp | 64 +
src/version/CMakeLists.txt | 4 +
src/version/version.cpp | 4 +
src/version/version.hpp | 6 +
51 files changed, 66315 insertions(+)
diff --git a/.VERSION.in b/.VERSION.in
new file mode 100644
index 0000000..4640e9f
--- /dev/null
+++ b/.VERSION.in
@@ -0,0 +1 @@
+${VERSION}
diff --git a/.gitignore b/.gitignore
new file mode 100644
index 0000000..113a175
--- /dev/null
+++ b/.gitignore
@@ -0,0 +1,2 @@
+/build*
+/local*
diff --git a/.gitmodules b/.gitmodules
new file mode 100644
index 0000000..c52248c
--- /dev/null
+++ b/.gitmodules
@@ -0,0 +1,9 @@
+[submodule "src/fast5"]
+ path = src/fast5
+ url = https://github.com/mateidavid/fast5.git
+[submodule "src/tclap"]
+ path = src/tclap
+ url = https://github.com/mateidavid/tclap.git
+[submodule "src/hpptools"]
+ path = src/hpptools
+ url = https://github.com/mateidavid/hpptools.git
diff --git a/.travis.yml b/.travis.yml
new file mode 100644
index 0000000..1638b68
--- /dev/null
+++ b/.travis.yml
@@ -0,0 +1,15 @@
+# travis.yml for github.com/mateidavid/nanocall
+
+sudo: required
+
+services: docker
+
+before_install:
+ - sudo apt-get update -y
+ - sudo apt-get install -y -o Dpkg::Options::="--force-confnew" docker-engine
+
+install: script/build-slim-docker-image
+
+before_script: docker images --all --no-trunc
+
+script: docker run --rm nanocall
diff --git a/.version_files b/.version_files
new file mode 100644
index 0000000..fd85e30
--- /dev/null
+++ b/.version_files
@@ -0,0 +1 @@
+VERSION
diff --git a/Dockerfile b/Dockerfile
new file mode 100644
index 0000000..e4c8c12
--- /dev/null
+++ b/Dockerfile
@@ -0,0 +1,30 @@
+FROM debian:stable
+MAINTAINER Matei David <matei.david.at.oicr.on.ca>
+ARG DEBIAN_FRONTEND=noninteractive
+
+# install prerequisites
+RUN apt-get update && \
+ apt-get install -y \
+ build-essential \
+ cmake \
+ libhdf5-dev
+
+# if necessary, specify compiler
+#RUN apt-get install -y g++-4.9 g++-5 g++-6
+#ENV CC=gcc-4.9
+#ENV CXX=g++-4.9
+
+# add source
+ADD . /src/
+
+# build and install
+RUN mkdir -p /src/build && \
+ cd /src/build && \
+ cmake ../src && \
+ make && \
+ make install
+
+VOLUME ["/data"]
+WORKDIR /data
+ENTRYPOINT ["/usr/local/bin/nanocall"]
+CMD ["--version"]
diff --git a/Dockerfile.slim.in b/Dockerfile.slim.in
new file mode 100644
index 0000000..58ddde2
--- /dev/null
+++ b/Dockerfile.slim.in
@@ -0,0 +1,19 @@
+FROM debian:stable
+MAINTAINER Matei David <matei.david.at.oicr.on.ca>
+ARG DEBIAN_FRONTEND=noninteractive
+
+ADD lddtree.tgz /
+
+# use host timezone
+ENV TZ=${TZ}
+RUN ln -snf /usr/share/zoneinfo/${TZ} /etc/localtime && echo ${TZ} > /etc/timezone
+
+# use host id
+RUN groupadd --gid ${GROUP_ID} ${GROUP_NAME}
+RUN useradd --create-home --uid ${USER_ID} --gid ${GROUP_ID} ${USER_NAME}
+USER ${USER_NAME}
+
+VOLUME ["/data"]
+WORKDIR /data
+ENTRYPOINT ["/usr/local/bin/nanocall"]
+CMD ["--version"]
diff --git a/HACKING.org b/HACKING.org
new file mode 100644
index 0000000..94d4c6e
--- /dev/null
+++ b/HACKING.org
@@ -0,0 +1,21 @@
+# -*- mode:org; mode:visual-line; coding:utf-8; -*-
+
+**** Change build type
+
+The default build type is =Release= (optimizations, no assertions). If any crashes are experienced, the first step in addressing them is to redo the run with a =Test= (optimizations, assertions) or =Debug= (no optimizations, assertions) build type. This is achieved using, e.g. =-DCMAKE_BUILD_TYPE=Test=.
+
+**** Using other packaged tools
+
+*Note*: The various tools are only built in =Test= or =Debug= build types.
+
+#+BEGIN_EXAMPLE
+FAST5_FILE=$SIMPSONLAB/data/nanopore/ecoli/sqk006/pass/LomanLabz_PC_Ecoli_K12_MG1655_20150924_MAP006_1_5005_1_ch9_file72_strand.fast5
+nanocall ${FAST5_FILE} > ${FAST5_FILE}.fa
+compute-state-transitions -p .001 -t .1 -k .1 >transitions.tsv
+compute-scaled-pore-model -f $FAST5_FILE >model.tsv
+get_events $FAST5_FILE | egrep -v '^(#|mean)' | tawk '{print $1,$3,$2,$4}' >events.tsv
+run-viterbi -d info -p model.tsv -s transitions.tsv -e events.tsv | { echo ">$(basename $FAST5_FILE)"; cat; } >out.fa
+run-viterbi -d debug -p model.tsv -s transitions.tsv -e <(awk 'NR>=100 && NR<200' events.tsv) |& tee log
+run-fwbw -d info -p model.tsv -s transitions.tsv -e <(awk 'NR>=100 && NR<200' events.tsv) -o fwbw.tsv
+#+END_EXAMPLE
+
diff --git a/LICENSE b/LICENSE
new file mode 100644
index 0000000..ecd41e2
--- /dev/null
+++ b/LICENSE
@@ -0,0 +1,22 @@
+The MIT License (MIT)
+
+Copyright (c) 2015 Matei David, Ontario Institute for Cancer Research
+Copyright (c) 2015 Jared Simpson, Ontario Institute for Cancer Research
+
+Permission is hereby granted, free of charge, to any person obtaining a copy
+of this software and associated documentation files (the "Software"), to deal
+in the Software without restriction, including without limitation the rights
+to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+copies of the Software, and to permit persons to whom the Software is
+furnished to do so, subject to the following conditions:
+
+The above copyright notice and this permission notice shall be included in all
+copies or substantial portions of the Software.
+
+THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
+AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+SOFTWARE.
diff --git a/README.org b/README.org
new file mode 100644
index 0000000..cf62a11
--- /dev/null
+++ b/README.org
@@ -0,0 +1,94 @@
+# -*- mode:org; mode:visual-line; coding:utf-8; -*-
+
+*** Nanocall: An Oxford Nanopore Basecaller
+
+[[http://travis-ci.org/mateidavid/nanocall][http://travis-ci.org/mateidavid/nanocall.svg?branch=master]]
+
+**** Installation
+
+Nanocall can be built from source in a classical UNIX environment, or directly under [[https://www.docker.com/what-docker][Docker]]. The Docker build might run under Windows, though this is not tested.
+
+***** Under a Classical UNIX Environment
+
+Nanocall uses =cmake= for configuration and =make= for building. The prerequisites needed for building are =zlib= and =hdf5=. On UNIX systems, =hdf5= can be optionally built as a submodule.
+Example build:
+
+#+BEGIN_EXAMPLE
+mkdir /some/source/dir && cd /some/source/dir
+git clone --recursive https://github.com/mateidavid/nanocall.git
+cd nanocall
+mkdir build && cd build
+cmake ../src [-DCMAKE_INSTALL_PREFIX=/some/install/dir] [-DBUILD_HDF5=1] [-DHDF5_ROOT=/path/to/hdf5]
+make
+make install
+/some/install/dir/bin/nanocall --version
+#+END_EXAMPLE
+
+*NOTES*:
+
+- The default install prefix is =/usr/local=.
+
+- Setting =BUILD_HDF5= will cause =hdf5= to be downloaded and built as a submodule.
+
+- Setting =HDF5_ROOT= is only necessary if a copy of =hdf5= is installed in a non-standard location. This is not needed when =BUILD_HDF5= is used.
+
+***** Under Docker
+
+To avoid dealing with prerequisites, Nanocall can be conveniently built under Docker. The installation and configuration of Docker itself is outside of the scope of this document.
+
+****** Simple "fat" build
+
+The simplest way to run Nanocall under Docker is:
+
+#+BEGIN_EXAMPLE
+docker build -t nanocall https://github.com/mateidavid/nanocall.git
+docker run --rm nanocall --version
+docker run --rm -u $(id -u):$(id -g) -v /path/to/data:/data nanocall -t 4 . >output.fa
+#+END_EXAMPLE
+
+Howver, there are several problems with this build:
+
+- The docker image is "fat", in that it contains all the build time dependencies of Nanocall, which are not needed at run time.
+
+- Without using =-u=, the image will create files with a UID of 0 on the mounted volumes of the host. To remove them, you will have to use =sudo rm= or =sudo chown=.
+
+- The timezone inside the image might be different from the host. This might confuse programs which depend on comparing modification times, most notably =make=.
+
+****** Alternate "slim" build
+
+To alleviate the problems mentioned above, you can build a "slim" Docker image as follows:
+
+#+BEGIN_EXAMPLE
+git clone --recursive --depth 1 https://github.com/mateidavid/nanocall.git
+nanocall/script/build-slim-docker-image
+docker run --rm nanocall --version
+docker run --rm -v /path/to/data:/data nanocall -t 4 . >output.fa
+#+END_EXAMPLE
+
+**** Usage Examples
+
+#+BEGIN_EXAMPLE
+# Check version
+nanocall --version
+
+# Check command line parameters
+nanocall --help
+
+# Run on single file, save output and log
+nanocall /path/to/file.fast5 >output.fa 2>log
+
+# Run on directory, using 24 threads, discard log
+nanocall -t 24 /path/to/data >output.fa 2>/dev/null
+
+# Run on file-of-file-names
+nanocall /path/to/files.fofn >output.fa
+
+# Run Docker build on directory, using 4 threads
+# Note: -u is not needed with the "slim" build
+docker run --rm -u $(id -u):$(id -g) -v /path/to/data:/data nanocall -t 4 . >output.fa
+#+END_EXAMPLE
+
+**** License
+
+Released under the [[file:LICENSE][MIT license]].
+
diff --git a/VERSION b/VERSION
new file mode 100644
index 0000000..fcbaa84
--- /dev/null
+++ b/VERSION
@@ -0,0 +1 @@
+0.6.14
diff --git a/context/nanocall/.gitignore b/context/nanocall/.gitignore
new file mode 100644
index 0000000..89c7bdd
--- /dev/null
+++ b/context/nanocall/.gitignore
@@ -0,0 +1,2 @@
+/Dockerfile
+/lddtree.tgz
diff --git a/script/build-slim-docker-image b/script/build-slim-docker-image
new file mode 100755
index 0000000..6dafa16
--- /dev/null
+++ b/script/build-slim-docker-image
@@ -0,0 +1,33 @@
+#!/bin/bash
+set -eEu
+trap 'echo "$0: line $LINENO: exit code $?" >&2' ERR
+log () { echo "$@" >&2; }
+crash () { log "error: $@"; exit 1; }
+
+_prog_path=$(readlink -e "${BASH_SOURCE[0]}")
+_prog_name=$(basename "$_prog_path")
+_prog_dir=$(dirname "$_prog_path")
+_prog_args=()
+
+export TZ=$(cat /etc/timezone)
+export USER_ID=$(id -u)
+export USER_NAME=$(id -un)
+export GROUP_ID=$(id -g)
+export GROUP_NAME=$(id -gn)
+ROOT_DIR=$(cd "$_prog_dir"/..; pwd -P)
+
+# build default fat image
+docker build -t nanocall:build "$ROOT_DIR"
+
+# extract lddtree for nanocall
+mkdir -p "$ROOT_DIR/build-slim-image"
+docker run --rm -v "$ROOT_DIR":/data --entrypoint=/bin/bash nanocall:build -c 'apt-get install -y pax-utils >/dev/null 2>&1 && /data/script/get-lddtree /usr/local/bin/nanocall' >"$ROOT_DIR"/build-slim-image/lddtree.tgz
+
+# remove fat image
+docker rmi nanocall:build
+
+# create slim Dockerfile
+envsubst <"$ROOT_DIR/Dockerfile.slim.in" >"$ROOT_DIR/build-slim-image/Dockerfile"
+
+# build slim image
+docker build -t nanocall "$ROOT_DIR/build-slim-image"
diff --git a/script/get-lddtree b/script/get-lddtree
new file mode 100755
index 0000000..d437ab4
--- /dev/null
+++ b/script/get-lddtree
@@ -0,0 +1,15 @@
+#!/bin/bash
+set -eEu
+trap 'echo "$0: line $LINENO: exit code $?" >&2' ERR
+log () { echo "$@" >&2; }
+crash () { log "error: $@"; exit 1; }
+
+_prog_path=$(readlink -e "${BASH_SOURCE[0]}")
+_prog_name=$(basename "$_prog_path")
+_prog_dir=$(dirname "$_prog_path")
+_prog_args=()
+
+lddtree -a -l "$@" |
+sort |
+uniq |
+tar -chvzf - --files-from -
diff --git a/src/.gitignore b/src/.gitignore
new file mode 100644
index 0000000..f1bd214
--- /dev/null
+++ b/src/.gitignore
@@ -0,0 +1 @@
+/optional*
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
new file mode 100644
index 0000000..01ad253
--- /dev/null
+++ b/src/CMakeLists.txt
@@ -0,0 +1,184 @@
+message(STATUS "Processing: ${CMAKE_CURRENT_SOURCE_DIR}")
+
+# set build type
+if(NOT CMAKE_BUILD_TYPE)
+ set(CMAKE_BUILD_TYPE "Release" CACHE STRING
+ "Choose the type of build, options are: Debug Test Release GProf GProfRel."
+ FORCE)
+endif()
+message(STATUS "Build type: ${CMAKE_BUILD_TYPE}")
+if(NOT ${CMAKE_BUILD_TYPE} AND NOT ${CMAKE_BUILD_TYPE} STREQUAL "Release")
+ set(CMAKE_VERBOSE_MAKEFILE TRUE CACHE BOOL "Enable verbose make output.")
+ message(STATUS "Enabling verbose make output.")
+endif()
+
+# general cmake settings
+cmake_minimum_required(VERSION 2.8.12)
+project(NANOCALL C CXX)
+set(CMAKE_MODULE_PATH ${CMAKE_MODULE_PATH} "${CMAKE_SOURCE_DIR}/cmake")
+include(CheckLibraryExists)
+include(CheckIncludeFileCXX)
+include(ExternalProject)
+
+# force out-of-source build
+if(${PROJECT_BINARY_DIR} STREQUAL ${PROJECT_SOURCE_DIR})
+ message(FATAL_ERROR "In-source build not supported.")
+endif()
+# check that "nanocall.cpp" exists; if not, assume the source dir is wrong
+if(NOT EXISTS "${PROJECT_SOURCE_DIR}/nanocall/nanocall.cpp")
+ message(FATAL_ERROR "${PROJECT_SOURCE_DIR}: source files not found")
+endif()
+
+# set project-related variables
+set(PACKAGE_BUGREPORT "mdavid at oicr.on.ca")
+set(PACKAGE_URL "https://github.com/jts/nanocall")
+set(PACKAGE "${PROJECT_NAME}")
+set(PACKAGE_NAME "${PROJECT_NAME}")
+set(PACKAGE_TARNAME "${PROJECT_NAME}")
+
+# directory where to build optional submodules
+set(OPTIONAL_SUBMODULE_PREFIX
+ ${PROJECT_SOURCE_DIR}/optional
+ CACHE INTERNAL "Directory for installing optional submodules")
+
+# header and source directories
+set(SUBDIRS
+ nanocall version
+ CACHE INTERNAL "Subdirectories to descend into")
+set(HEADER_SUBDIRS
+ builtin_models fast5/src hpptools/include tclap/include
+ nanocall version
+ CACHE INTERNAL "Subdirectories containing header files")
+
+### Resolve external dependencies
+#
+# prefer static libraries
+#set(CMAKE_FIND_LIBRARY_SUFFIXES .a .so)
+
+# bake-in RPATH to prevent library search problems
+set(CMAKE_INSTALL_RPATH_USE_LINK_PATH true)
+set(CMAKE_BUILD_WITH_INSTALL_RPATH true)
+set(CMAKE_LIBRARY_PATH $ENV{LD_LIBRARY_PATH})
+
+# find zlib
+# => ZLIB_INCLUDE_DIRS, ZLIB_LIBRARIES
+find_package(ZLIB REQUIRED)
+
+# find HDF5
+# => HDF5_INCLUDE_DIRS, HDF5_LIBRARIES
+if(BUILD_HDF5)
+ message(STATUS "Building HDF5 in: ${OPTIONAL_SUBMODULE_PREFIX}")
+ if(UNIX)
+ # use local copy if available
+ if(EXISTS /tmp/hdf5-1.8.16.tar.bz2)
+ set(HDF5_URL /tmp/hdf5-1.8.16.tar.bz2)
+ else()
+ set(HDF5_URL http://www.hdfgroup.org/ftp/HDF5/releases/hdf5-1.8.16/src/hdf5-1.8.16.tar.bz2)
+ endif()
+ ExternalProject_Add(hdf5
+ PREFIX ${OPTIONAL_SUBMODULE_PREFIX}
+ URL ${HDF5_URL}
+ URL_MD5 79c1593573ebddf734eee8d43ecfe483
+ CONFIGURE_COMMAND ./configure --prefix=${OPTIONAL_SUBMODULE_PREFIX} --disable-hl --disable-shared --enable-threadsafe
+ BUILD_IN_SOURCE 1
+ BUILD_COMMAND make
+ INSTALL_COMMAND make install
+ )
+ set(HDF5_INCLUDE_DIRS ${OPTIONAL_SUBMODULE_PREFIX}/include)
+ set(HDF5_LIBRARIES ${OPTIONAL_SUBMODULE_PREFIX}/lib/libhdf5.a)
+ elseif(WIN32)
+ message(FATAL_ERROR "Building HDF5 not supported on Windows")
+ endif()
+else()
+ find_package(HDF5 1.8.11 REQUIRED)
+endif()
+
+# Problem:
+#
+# By default, if using target_link_libraries(... ${HDF5_LIBRARIES}), cmake
+# attempts to use the short name "-lhdf5" as an argument to ld, *without* setting
+# "-L" appropriately. It's unclear why, or if this is related to LD_LIBRARY_PATH.
+# The problem arises if an older libhdf5 is found instead. The solution below
+# uses an IMPORTED library. In this case, cmake will use the full path during
+# linking.
+#
+# Also, setting up RPATH apropriately using cmake is... elusive. If baking-in of
+# linker paths is needed, be sure to use LD_RUN_PATH during make- this will be
+# honoured by g++.
+#
+# Refs:
+# https://cmake.org/pipermail/cmake/2013-December/056655.html
+# https://cmake.org/Wiki/CMake/Tutorials/Exporting_and_Importing_Targets
+#
+add_library(libhdf5 UNKNOWN IMPORTED)
+set_property(TARGET libhdf5 PROPERTY IMPORTED_LOCATION ${HDF5_LIBRARIES})
+#get_filename_component(HDF5_LIBRARIES_DIR ${HDF5_LIBRARIES} DIRECTORY)
+#set(CMAKE_INSTALL_RPATH ${HDF5_LIBRARIES_DIR})
+
+message(STATUS "HDF5_INCLUDE_DIRS=${HDF5_INCLUDE_DIRS}")
+message(STATUS "HDF5_LIBRARIES=${HDF5_LIBRARIES}")
+
+# message(STATUS "CMAKE_LIBRARY_PATH=${CMAKE_LIBRARY_PATH}")
+# message(STATUS "CMAKE_SYSTEM_LIBRARY_PATH=${CMAKE_SYSTEM_LIBRARY_PATH}")
+# message(STATUS "CMAKE_PLATFORM_IMPLICIT_LINK_DIRECTORIES=${CMAKE_PLATFORM_IMPLICIT_LINK_DIRECTORIES}")
+# message(STATUS "CMAKE_INSTALL_RPATH=${CMAKE_INSTALL_RPATH}")
+# message(STATUS "CMAKE_INSTALL_RPATH_USE_LINK_PATH=${CMAKE_INSTALL_RPATH_USE_LINK_PATH}")
+# message(STATUS "CMAKE_BUILD_WITH_INSTALL_RPATH=${CMAKE_BUILD_WITH_INSTALL_RPATH}")
+# message(STATUS "CMAKE_SKIP_BUILD_RPATH=${CMAKE_SKIP_BUILD_RPATH}")
+
+### Prepare default compilation flags
+#
+# headers
+include_directories(SYSTEM
+ ${ZLIB_INCLUDE_DIRS}
+ ${HDF5_INCLUDE_DIRS}
+ )
+include_directories(
+ ${PROJECT_BINARY_DIR}
+ ${HEADER_SUBDIRS}
+ )
+get_directory_property(include_directories INCLUDE_DIRECTORIES)
+message(STATUS "INCLUDE_DIRECTORIES='${include_directories}'")
+
+### general compile flags
+set(EXTRA_FLAGS "-std=c++11 -pthread -Wall -Wextra -pedantic")
+
+# compiler-specific flags
+if ("${CMAKE_CXX_COMPILER_ID}" STREQUAL "GNU")
+ set(EXTRA_FLAGS "${EXTRA_FLAGS} -fmax-errors=1")
+elseif ("${CMAKE_CXX_COMPILER_ID}" STREQUAL "Clang")
+ set(EXTRA_FLAGS "${EXTRA_FLAGS} -ferror-limit=1")
+endif()
+
+# consolidate compile flags
+set(CMAKE_CXX_FLAGS "$ENV{CXXFLAGS} ${EXTRA_FLAGS}")
+message(STATUS "CMAKE_CXX_FLAGS='${CMAKE_CXX_FLAGS}'")
+
+### build-specific compile flags
+set(CMAKE_CXX_FLAGS_DEBUG "-O0 -g3 -ggdb -fno-inline -fno-eliminate-unused-debug-types")
+set(CMAKE_CXX_FLAGS_TEST "-O3 -g3 -fno-eliminate-unused-debug-types")
+set(CMAKE_CXX_FLAGS_TEST_O2 "-O2 -g3 -fno-eliminate-unused-debug-types")
+set(CMAKE_CXX_FLAGS_TEST_O1 "-O1 -g3 -fno-eliminate-unused-debug-types")
+set(CMAKE_CXX_FLAGS_RELEASE "-O3 -DNDEBUG -DDISABLE_ASSERTS")
+set(CMAKE_CXX_FLAGS_GPROF "-O3 -g3 -pg")
+set(CMAKE_CXX_FLAGS_GPROFREL "-O3 -DNDEBUG -DDISABLE_ASSERTS -pg")
+
+# link flags
+#set(CMAKE_EXE_LINKER_FLAGS "-Wl,-rpath=$ENV{LD_RUN_PATH} -Wl,--as-needed")
+set(CMAKE_EXE_LINKER_FLAGS "-Wl,--as-needed")
+message(STATUS "CMAKE_EXE_LINKER_FLAGS='${CMAKE_EXE_LINKER_FLAGS}'")
+
+### This target updates the package version
+#
+add_custom_target(package_version
+ ${PROJECT_SOURCE_DIR}/get-dir-version -v -d ${PROJECT_SOURCE_DIR}/.. -r ${PROJECT_SOURCE_DIR}/.. -o ${PROJECT_BINARY_DIR}/package_version.h -t PACKAGE_VERSION
+ )
+
+### Enable testing targets
+#enable_testing()
+
+### Descend into subdirectories
+#
+foreach(dir ${SUBDIRS})
+ add_subdirectory(${dir})
+endforeach()
diff --git a/src/Makefile b/src/Makefile
new file mode 100644
index 0000000..5421508
--- /dev/null
+++ b/src/Makefile
@@ -0,0 +1,35 @@
+SHELL := /bin/bash
+
+HDF_ROOT = /usr
+
+OPT_FLAG = -O0
+CXXFLAGS = -Wall -Wextra -pedantic -g3 -ggdb -fno-eliminate-unused-debug-types ${OPT_FLAG}
+M_CXXFLAGS = -std=c++11 -pthread
+CPPFLAGS = -isystem ${HDF_ROOT}/include -I fast5/src -I tclap/include -I hpptools/include
+
+TARGETS = compute-state-transitions compute-scaled-pore-model run-fwbw run-viterbi nanocall
+
+.PHONY: all test clean
+
+all: ${TARGETS}
+
+clean:
+ rm -rf ${TARGETS}
+
+compute-state-transitions: compute-state-transitions.cpp
+ ${CXX} ${M_CXXFLAGS} ${CXXFLAGS} ${CPPFLAGS} $^ -o $@ ${LDFLAGS}
+
+compute-scaled-pore-model: compute-scaled-pore-model.cpp
+ ${CXX} ${M_CXXFLAGS} ${CXXFLAGS} ${CPPFLAGS} $^ -o $@ ${LDFLAGS} -L ${HDF_ROOT}/lib -lhdf5
+
+run-fwbw: run-fwbw.cpp
+ ${CXX} ${M_CXXFLAGS} ${CXXFLAGS} ${CPPFLAGS} $^ -o $@ ${LDFLAGS} -lz
+
+run-viterbi: run-viterbi.cpp
+ ${CXX} ${M_CXXFLAGS} ${CXXFLAGS} ${CPPFLAGS} $^ -o $@ ${LDFLAGS} -lz
+
+nanocall: nanocall.cpp Builtin_Model.cpp
+ ${CXX} ${M_CXXFLAGS} ${CXXFLAGS} ${CPPFLAGS} $^ -o $@ ${LDFLAGS} -L ${HDF_ROOT}/lib -lhdf5 -lz
+
+list-directory: list-directory.cpp
+ ${CXX} ${M_CXXFLAGS} ${CXXFLAGS} ${CPPFLAGS} $^ -o $@ ${LDFLAGS}
diff --git a/src/builtin_models/.gitignore b/src/builtin_models/.gitignore
new file mode 100644
index 0000000..0149797
--- /dev/null
+++ b/src/builtin_models/.gitignore
@@ -0,0 +1 @@
+*.model
diff --git a/src/builtin_models/builtin_model_init_lists.inl b/src/builtin_models/builtin_model_init_lists.inl
new file mode 100644
index 0000000..78ead98
--- /dev/null
+++ b/src/builtin_models/builtin_model_init_lists.inl
@@ -0,0 +1,49165 @@
+{
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diff --git a/src/builtin_models/builtin_model_names.inl b/src/builtin_models/builtin_model_names.inl
new file mode 100644
index 0000000..8663262
--- /dev/null
+++ b/src/builtin_models/builtin_model_names.inl
@@ -0,0 +1,13 @@
+{
+ "r73.t.006.ont.model"
+ ,
+ "r73.c.p1.006.ont.model"
+ ,
+ "r73.c.p2.006.ont.model"
+ ,
+ "r9.t.006.ont.model"
+ ,
+ "r9.c.p1.006.ont.model"
+ ,
+ "r9.c.p2.006.ont.model"
+}
diff --git a/src/builtin_models/builtin_model_num.inl b/src/builtin_models/builtin_model_num.inl
new file mode 100644
index 0000000..1e8b314
--- /dev/null
+++ b/src/builtin_models/builtin_model_num.inl
@@ -0,0 +1 @@
+6
diff --git a/src/builtin_models/builtin_model_strands.inl b/src/builtin_models/builtin_model_strands.inl
new file mode 100644
index 0000000..1b9a395
--- /dev/null
+++ b/src/builtin_models/builtin_model_strands.inl
@@ -0,0 +1,13 @@
+{
+ 0
+ ,
+ 1
+ ,
+ 1
+ ,
+ 0
+ ,
+ 1
+ ,
+ 1
+}
diff --git a/src/builtin_models/make-builtin-model-initializers b/src/builtin_models/make-builtin-model-initializers
new file mode 100755
index 0000000..eff89b8
--- /dev/null
+++ b/src/builtin_models/make-builtin-model-initializers
@@ -0,0 +1,73 @@
+#!/usr/bin/env python3
+
+import argparse
+import os
+import re
+import sys
+
+description = '''
+ Transform the given model files into C++ initializer list suitable for inclusion during preprocessing.
+'''
+default_files = [
+ '0:r73.t.006.ont.model',
+ '1:r73.c.p1.006.ont.model',
+ '1:r73.c.p2.006.ont.model',
+ '0:r9.t.006.ont.model',
+ '1:r9.c.p1.006.ont.model',
+ '1:r9.c.p2.006.ont.model']
+parser = argparse.ArgumentParser(description=description, epilog='')
+parser.add_argument('input', nargs='*', default=default_files, help='Input models, in the form <strand>:<file>')
+args = parser.parse_args()
+
+m_strands = list()
+m_names = list()
+
+for fn in args.input:
+ if fn[0] not in '012' or fn[1] != ':':
+ print('error parsing model name [' + fn + ']: expecting <strand>:<file>', file=sys.stderr)
+ sys.exit(1)
+ m_strands.append(int(fn[0]))
+ m_names.append(fn[2:])
+
+f_out = open('builtin_model_num.inl', 'w')
+print(str(len(m_names)), file=f_out)
+f_out.close()
+
+f_out = open('builtin_model_names.inl', 'w')
+print('{', file=f_out)
+for i in range(len(m_names)):
+ if i > 0:
+ print(' ,', file=f_out)
+ print(' "' + m_names[i] + '"', file=f_out)
+print('}', file=f_out)
+f_out.close()
+
+f_out = open('builtin_model_strands.inl', 'w')
+print('{', file=f_out)
+for i in range(len(m_strands)):
+ if i > 0:
+ print(' ,', file=f_out)
+ print(' ' + str(m_strands[i]), file=f_out)
+print('}', file=f_out)
+f_out.close()
+
+f_out = open('builtin_model_init_lists.inl', 'w')
+print('{', file=f_out)
+for i in range(len(m_names)):
+ if i > 0:
+ print(' ,', file=f_out)
+ print(' {', file=f_out)
+ f = open(m_names[i])
+ first_line = True
+ for line in f:
+ l = line.strip().split()
+ if len(l) < 5 or re.search(r'[^ACGT]', l[0].upper()) != None:
+ continue
+ if not first_line:
+ print(' ,', file=f_out)
+ first_line = False
+ print(' ' + ', '.join(l[1:5]), file=f_out)
+ print(' }', file=f_out)
+print('}', file=f_out)
+f_out.close()
+
diff --git a/src/builtin_models/r73.c.p1.006.ont.model b/src/builtin_models/r73.c.p1.006.ont.model
new file mode 100644
index 0000000..b36665e
--- /dev/null
+++ b/src/builtin_models/r73.c.p1.006.ont.model
@@ -0,0 +1,4096 @@
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+AAATAT 58.663745 1.341513 0.834131 0.300225
+AAATCA 54.795497 1.896912 1.051446 0.424889
+AAATCC 51.881556 1.162641 1.036871 0.416085
+AAATCG 54.651201 1.779404 1.071264 0.436958
+AAATCT 53.234446 1.179011 0.919636 0.347551
+AAATGA 54.763669 0.935908 1.043467 0.420062
+AAATGC 50.830781 1.036208 1.328812 0.603657
+AAATGG 54.68934 0.884362 0.799398 0.281669
+AAATGT 53.338549 0.735699 0.822518 0.293977
+AAATTA 49.847872 0.852899 1.115758 0.464462
+AAATTC 45.694647 1.084019 1.34835 0.61702
+AAATTG 49.212786 0.761218 0.973331 0.37843
+AAATTT 46.621463 1.108203 1.105056 0.457796
+AACAAA 65.241517 1.193427 0.916824 0.345959
+AACAAC 60.893326 1.484444 0.874906 0.322506
+AACAAG 66.226756 0.891347 0.904504 0.339009
+AACAAT 64.761971 0.92566 1.075288 0.439423
+AACACA 64.242062 1.115075 0.816978 0.291012
+AACACC 61.726356 0.766571 0.68734 0.22457
+AACACG 64.046171 1.075055 0.813114 0.28895
+AACACT 63.347652 0.75711 0.84371 0.305411
+AACAGA 66.562702 1.114444 0.969907 0.376436
+AACAGC 62.946325 2.042448 0.936256 0.357016
+AACAGG 66.420034 1.021947 0.986113 0.38591
+AACAGT 65.587154 1.169127 1.432449 0.675638
+AACATA 62.916323 1.568072 0.834269 0.300299
+AACATC 58.814697 1.367981 0.98042 0.382572
+AACATG 61.642946 1.473169 0.996145 0.391813
+AACATT 59.828394 1.956931 1.188733 0.510766
+AACCAA 67.223139 1.171141 1.085974 0.445989
+AACCAC 64.587341 0.821548 0.816238 0.290616
+AACCAG 68.663073 1.201577 1.138503 0.478736
+AACCAT 67.510924 1.069383 1.197802 0.516622
+AACCCA 65.37699 1.572307 1.184376 0.50796
+AACCCC 62.811084 1.365274 0.903657 0.338533
+AACCCG 65.102812 1.714351 1.098144 0.453507
+AACCCT 64.587175 1.424966 1.029569 0.411698
+AACCGA 67.967861 1.227567 1.026163 0.409657
+AACCGC 64.681524 0.875503 0.786161 0.274702
+AACCGG 67.104195 1.288772 1.160134 0.492445
+AACCGT 65.749921 1.330567 1.552309 0.762189
+AACCTA 63.250409 0.894487 0.804328 0.284279
+AACCTC 60.132024 1.840931 0.830462 0.298246
+AACCTG 62.237112 0.957732 0.999461 0.393771
+AACCTT 60.508782 1.353181 1.162384 0.493878
+AACGAA 70.286268 1.708938 1.238534 0.543196
+AACGAC 64.316239 0.927239 0.824128 0.294841
+AACGAG 69.949859 1.444337 1.182312 0.506633
+AACGAT 67.548967 1.094368 1.25095 0.551385
+AACGCA 67.07501 2.147385 1.08312 0.444232
+AACGCC 63.654627 1.231513 0.750833 0.256395
+AACGCG 66.825356 1.995199 1.082259 0.443703
+AACGCT 65.974007 1.42051 1.054508 0.426747
+AACGGA 64.481219 1.379109 0.929009 0.352878
+AACGGC 58.78211 1.506421 1.036471 0.415844
+AACGGG 63.890637 1.312314 1.009062 0.399459
+AACGGT 62.657805 1.692707 1.316102 0.595017
+AACGTA 53.111834 1.868436 1.227306 0.535827
+AACGTC 47.052933 2.045543 1.52524 0.74234
+AACGTG 52.298652 1.809597 1.253964 0.553379
+AACGTT 49.319135 2.205833 1.427722 0.672296
+AACTAA 64.145153 1.336093 0.83949 0.303123
+AACTAC 59.940884 0.733949 0.640415 0.20197
+AACTAG 64.163184 1.597625 1.056599 0.428017
+AACTAT 62.225599 0.905268 0.837854 0.302237
+AACTCA 59.860825 1.462373 0.79649 0.280134
+AACTCC 57.404642 1.089368 0.776658 0.269737
+AACTCG 59.724334 1.303133 0.769122 0.26582
+AACTCT 58.962938 1.382489 0.772556 0.267603
+AACTGA 55.962122 1.105578 0.885833 0.328566
+AACTGC 51.379844 1.067078 1.216523 0.528781
+AACTGG 56.715516 0.852752 0.761607 0.261934
+AACTGT 54.841596 0.742319 0.912013 0.343239
+AACTTA 51.368306 1.004438 1.02015 0.406061
+AACTTC 45.987943 1.06367 1.335429 0.608172
+AACTTG 50.51815 0.87429 0.914734 0.344776
+AACTTT 47.102411 1.547031 1.068269 0.435127
+AAGAAA 71.208633 1.357049 1.341569 0.612371
+AAGAAC 65.51665 1.638287 1.160122 0.492437
+AAGAAG 71.631685 1.274416 1.316927 0.595577
+AAGAAT 69.448136 2.378307 1.599393 0.797128
+AAGACA 63.373822 1.866538 0.770103 0.266329
+AAGACC 58.50845 0.702623 0.79378 0.278706
+AAGACG 61.239563 1.155135 0.767977 0.265227
+AAGACT 60.583247 0.809928 0.834913 0.300647
+AAGAGA 69.749556 1.458859 1.201547 0.519047
+AAGAGC 63.754675 1.861615 1.025783 0.409429
+AAGAGG 68.726445 1.388488 1.209209 0.524019
+AAGAGT 67.148927 1.457099 1.552129 0.762057
+AAGATA 60.089066 1.201228 0.928176 0.352404
+AAGATC 55.382033 1.530081 1.251131 0.551505
+AAGATG 59.141695 1.453707 1.051479 0.424909
+AAGATT 56.56481 2.003036 1.35476 0.621425
+AAGCAA 69.428109 1.134813 1.108609 0.460006
+AAGCAC 66.394367 1.035012 0.949184 0.364436
+AAGCAG 69.936749 1.060824 1.033412 0.414005
+AAGCAT 68.678387 1.18733 1.28721 0.575532
+AAGCCA 64.400019 1.159743 0.835176 0.300789
+AAGCCC 62.129738 0.847014 0.733901 0.247772
+AAGCCG 64.022877 1.214304 0.843952 0.305543
+AAGCCT 63.851684 0.942193 0.835848 0.301152
+AAGCGA 69.19773 1.189777 0.987769 0.386882
+AAGCGC 65.26525 1.016335 0.943074 0.360922
+AAGCGG 67.637442 1.090153 1.109851 0.460779
+AAGCGT 66.162666 1.13176 1.579743 0.782483
+AAGCTA 63.350001 1.017649 0.900731 0.33689
+AAGCTC 60.07697 1.202168 0.84411 0.305628
+AAGCTG 62.270787 1.186411 1.111092 0.461552
+AAGCTT 60.485544 1.761598 1.241458 0.545122
+AAGGAA 74.438183 2.331036 1.533114 0.748095
+AAGGAC 65.479543 1.653833 0.948039 0.363776
+AAGGAG 73.503057 2.21875 1.539304 0.75263
+AAGGAT 70.710264 1.819131 1.509202 0.730662
+AAGGCA 67.532804 2.442485 1.246803 0.548646
+AAGGCC 63.718675 1.711975 0.961764 0.371704
+AAGGCG 67.15859 2.526859 1.251787 0.551939
+AAGGCT 66.508232 2.071192 1.223917 0.533609
+AAGGGA 67.685375 1.48959 1.176107 0.50265
+AAGGGC 60.686691 1.026772 1.089618 0.448236
+AAGGGG 66.504968 1.229998 1.054518 0.426753
+AAGGGT 66.083731 1.292894 1.158424 0.491357
+AAGGTA 58.025757 0.918063 0.989658 0.387992
+AAGGTC 51.434262 1.221726 1.273262 0.566203
+AAGGTG 57.132897 1.139422 1.029906 0.4119
+AAGGTT 53.595445 1.285511 1.311568 0.591945
+AAGTAA 59.41944 1.389659 0.978976 0.381727
+AAGTAC 54.702369 0.858127 0.952121 0.366129
+AAGTAG 58.794433 1.743506 0.945471 0.362299
+AAGTAT 57.271431 1.628552 0.897944 0.335327
+AAGTCA 52.568902 1.887288 1.207937 0.523192
+AAGTCC 49.57799 1.18564 1.120514 0.467435
+AAGTCG 52.10187 1.541793 1.152963 0.487886
+AAGTCT 51.06815 1.31367 1.057296 0.42844
+AAGTGA 54.553117 0.895141 1.07745 0.440749
+AAGTGC 50.426697 0.86542 1.155574 0.489544
+AAGTGG 54.160516 0.910172 0.985059 0.385291
+AAGTGT 52.952442 1.050079 0.947534 0.363486
+AAGTTA 49.024297 0.810614 1.031824 0.413051
+AAGTTC 45.157201 0.922688 1.215319 0.527996
+AAGTTG 48.23569 0.696808 0.884644 0.327905
+AAGTTT 46.137496 0.910465 0.982217 0.383625
+AATAAA 64.805494 0.955924 0.825817 0.295748
+AATAAC 60.630226 0.996733 0.785064 0.274128
+AATAAG 65.675387 0.923556 0.917055 0.346089
+AATAAT 64.024592 1.046018 1.032953 0.413729
+AATACA 61.500376 1.790252 0.953021 0.366648
+AATACC 59.180194 1.060842 0.754374 0.258211
+AATACG 61.470358 1.460316 0.939669 0.35897
+AATACT 61.082215 1.336964 0.852504 0.310199
+AATAGA 64.512276 0.973836 0.8382 0.302425
+AATAGC 60.828633 0.936755 0.834745 0.300556
+AATAGG 64.195582 1.046379 0.830316 0.298168
+AATAGT 62.953587 1.197116 1.177014 0.503232
+AATATA 59.763264 0.678972 0.698256 0.229942
+AATATC 56.021183 1.373783 0.792208 0.277878
+AATATG 59.054529 0.823008 0.88495 0.328075
+AATATT 56.906431 1.623574 1.050988 0.424612
+AATCAA 63.883694 1.546078 1.080812 0.442813
+AATCAC 61.481668 0.924337 0.798021 0.280942
+AATCAG 64.261763 2.26116 1.343212 0.613497
+AATCAT 63.938784 1.412752 1.206358 0.522167
+AATCCA 60.362829 2.218712 1.277744 0.569195
+AATCCC 58.466388 1.591119 1.146768 0.483959
+AATCCG 60.473171 1.940287 1.303315 0.586367
+AATCCT 59.552476 2.237348 1.120032 0.467133
+AATCGA 63.337882 1.934298 1.183002 0.507076
+AATCGC 60.909366 1.090433 0.959241 0.370243
+AATCGG 63.127242 1.462579 1.205903 0.521872
+AATCGT 61.59702 1.560835 1.444252 0.684006
+AATCTA 59.376386 1.015327 0.858342 0.31339
+AATCTC 56.638107 0.713531 0.718799 0.240163
+AATCTG 58.157133 1.002426 0.908173 0.341074
+AATCTT 56.671269 0.875026 0.990589 0.38854
+AATGAA 65.075566 2.61176 1.49599 0.721088
+AATGAC 57.936166 1.87526 0.898119 0.335425
+AATGAG 62.83456 2.61176 1.32437 0.600633
+AATGAT 62.120622 1.822578 1.345802 0.615272
+AATGCA 60.435696 2.61176 1.446507 0.685608
+AATGCC 56.994337 2.133658 1.297186 0.582235
+AATGCG 59.766219 2.61176 1.395251 0.649492
+AATGCT 59.655245 2.61176 1.385735 0.642859
+AATGGA 60.775702 1.660392 1.119911 0.467058
+AATGGC 56.242358 0.867842 1.012017 0.401215
+AATGGG 59.625875 1.287708 1.00306 0.3959
+AATGGT 59.080893 1.302642 1.083713 0.444597
+AATGTA 52.298258 0.808745 0.817803 0.291453
+AATGTC 46.576653 1.116147 1.047145 0.422285
+AATGTG 51.363278 1.097756 0.838475 0.302573
+AATGTT 48.481293 1.214111 0.963669 0.372809
+AATTAA 58.17543 2.083135 1.164445 0.495192
+AATTAC 54.538419 1.534937 0.962378 0.372061
+AATTAG 57.720467 2.104909 1.179351 0.504731
+AATTAT 56.876621 1.901994 1.100379 0.454892
+AATTCA 52.362687 2.281809 1.239818 0.544042
+AATTCC 50.232356 1.844063 1.115578 0.464349
+AATTCG 51.881583 1.969334 1.312571 0.592624
+AATTCT 51.413249 1.545401 1.048726 0.423242
+AATTGA 52.682053 0.983019 1.059315 0.429668
+AATTGC 49.382002 0.885281 1.133091 0.475327
+AATTGG 52.891409 1.240195 0.935626 0.356655
+AATTGT 51.83374 0.957975 0.878425 0.324454
+AATTTA 48.121731 0.965338 1.015982 0.403575
+AATTTC 44.272785 0.751598 1.044769 0.420848
+AATTTG 47.406398 0.87742 0.846872 0.30713
+AATTTT 45.070446 0.651358 0.704286 0.232926
+ACAAAA 64.364862 1.217987 0.833827 0.300061
+ACAAAC 58.969323 1.204677 0.890404 0.331113
+ACAAAG 64.276706 0.695291 0.842902 0.304973
+ACAAAT 62.392311 0.837529 1.08222 0.443678
+ACAACA 58.960801 0.848094 0.856496 0.31238
+ACAACC 56.384461 0.749703 0.906639 0.34021
+ACAACG 58.611853 0.889996 0.855352 0.311755
+ACAACT 58.160147 0.854781 0.837586 0.302092
+ACAAGA 65.198749 1.442175 0.867251 0.318282
+ACAAGC 60.046499 0.973232 0.949016 0.364339
+ACAAGG 63.858205 0.892973 0.846015 0.306664
+ACAAGT 62.008345 1.853701 1.195842 0.515355
+ACAATA 58.442219 1.390704 0.950965 0.365462
+ACAATC 55.292851 2.192235 1.182588 0.506811
+ACAATG 57.629048 1.479056 1.090466 0.448759
+ACAATT 55.640241 1.825476 1.287418 0.575671
+ACACAA 67.265822 0.855514 0.904352 0.338923
+ACACAC 64.627434 0.996428 0.734944 0.2483
+ACACAG 68.155562 0.986403 0.907255 0.340557
+ACACAT 67.100607 0.901259 1.123778 0.469479
+ACACCA 63.964305 1.077618 0.746659 0.254261
+ACACCC 61.605352 0.879161 0.725624 0.243592
+ACACCG 63.542243 0.953409 0.74892 0.255416
+ACACCT 63.294427 1.051596 0.852255 0.310063
+ACACGA 67.042616 1.148309 0.803206 0.283685
+ACACGC 64.414615 1.361659 0.776923 0.269875
+ACACGG 66.112582 0.952264 0.855332 0.311744
+ACACGT 65.178941 0.980138 1.288371 0.576311
+ACACTA 62.087709 0.692692 0.687371 0.224586
+ACACTC 58.948783 1.027697 0.828817 0.29736
+ACACTG 61.263228 1.061518 0.850292 0.308992
+ACACTT 59.2892 1.483137 1.141897 0.480879
+ACAGAA 68.696282 1.834186 0.996061 0.391764
+ACAGAC 60.923694 0.843215 0.830634 0.298339
+ACAGAG 67.72094 1.839212 0.96741 0.374983
+ACAGAT 64.791847 1.034031 1.0903 0.448657
+ACAGCA 62.990458 1.661923 1.021795 0.407044
+ACAGCC 59.452933 0.895393 0.901024 0.337054
+ACAGCG 62.453925 1.835712 0.96265 0.372218
+ACAGCT 62.281848 1.707614 0.937435 0.35769
+ACAGGA 64.765952 1.245126 0.960634 0.37105
+ACAGGC 58.87715 1.170209 1.25637 0.554973
+ACAGGG 63.483245 0.832874 0.85036 0.309029
+ACAGGT 62.243745 0.948479 1.083248 0.444311
+ACAGTA 54.554561 1.679738 1.192326 0.513083
+ACAGTC 48.750767 1.70083 1.552024 0.761979
+ACAGTG 54.028966 1.768546 1.266365 0.561608
+ACAGTT 50.588388 1.903872 1.596597 0.795039
+ACATAA 61.666214 0.879056 0.77435 0.268535
+ACATAC 57.640358 0.744852 0.811333 0.288001
+ACATAG 61.468592 0.989092 0.747621 0.254752
+ACATAT 59.89342 0.721456 0.778012 0.270442
+ACATCA 56.245066 0.837983 0.877861 0.324141
+ACATCC 54.054004 0.906263 0.997965 0.392888
+ACATCG 56.003224 0.783545 0.852985 0.310461
+ACATCT 55.151836 0.634197 0.788165 0.275754
+ACATGA 55.974645 1.170706 1.221936 0.532314
+ACATGC 51.215816 1.203435 1.52238 0.740253
+ACATGG 55.811385 0.811468 0.971893 0.377592
+ACATGT 53.874563 0.841034 1.156354 0.49004
+ACATTA 50.588557 1.046226 1.404428 0.65591
+ACATTC 45.830626 1.154631 1.530597 0.746254
+ACATTG 49.871509 0.971836 1.227896 0.536214
+ACATTT 46.870426 1.286136 1.493324 0.719161
+ACCAAA 65.259015 1.493913 0.943335 0.361072
+ACCAAC 60.351328 1.334655 0.970628 0.376855
+ACCAAG 65.953887 1.190935 0.997218 0.392447
+ACCAAT 64.278365 1.07309 1.22714 0.535718
+ACCACA 65.52566 1.678828 0.834284 0.300308
+ACCACC 61.886518 0.684955 0.745719 0.25378
+ACCACG 64.363433 1.165221 0.784462 0.273812
+ACCACT 63.602015 0.717041 0.836222 0.301354
+ACCAGA 67.007714 1.632571 0.937173 0.35754
+ACCAGC 62.47871 1.435206 1.028492 0.411052
+ACCAGG 66.820346 1.234155 0.989658 0.387992
+ACCAGT 65.82663 1.707473 1.528626 0.744813
+ACCATA 63.283877 1.351447 0.889514 0.330617
+ACCATC 59.2264 1.666461 1.108471 0.45992
+ACCATG 62.066106 1.680528 1.107518 0.459327
+ACCATT 60.383797 2.416368 1.384337 0.641886
+ACCCAA 68.464318 0.940265 0.982583 0.383839
+ACCCAC 65.845669 1.04145 0.834335 0.300335
+ACCCAG 69.911393 1.000061 0.941306 0.359908
+ACCCAT 68.747229 0.736877 1.079528 0.442024
+ACCCCA 67.047236 1.124759 0.817068 0.29106
+ACCCCC 64.90566 0.836432 0.628293 0.196263
+ACCCCG 67.035667 1.165023 0.846819 0.307101
+ACCCCT 66.617541 0.79125 0.906501 0.340132
+ACCCGA 69.416936 0.893981 0.912338 0.343423
+ACCCGC 65.875576 1.130747 0.820835 0.293075
+ACCCGG 68.631668 0.863528 0.996317 0.391915
+ACCCGT 67.316674 0.88586 1.513648 0.733893
+ACCCTA 64.684451 2.072994 0.795798 0.279769
+ACCCTC 62.002976 1.692494 0.837443 0.302015
+ACCCTG 63.818866 1.346463 0.989709 0.388022
+ACCCTT 62.050567 1.927762 1.203246 0.520148
+ACCGAA 70.275475 1.144625 1.017116 0.404251
+ACCGAC 64.038576 1.053866 0.830982 0.298526
+ACCGAG 69.82585 0.974409 0.968535 0.375637
+ACCGAT 67.516998 1.18695 1.186011 0.509013
+ACCGCA 67.166478 1.542007 0.859693 0.31413
+ACCGCC 63.965603 0.857233 0.660475 0.211534
+ACCGCG 66.692659 1.375557 0.879373 0.324979
+ACCGCT 65.984602 1.028348 0.870634 0.320146
+ACCGGA 64.739169 1.528413 0.983185 0.384192
+ACCGGC 58.640595 1.42399 1.210048 0.524565
+ACCGGG 64.054111 1.659237 1.058378 0.429098
+ACCGGT 62.574155 2.063576 1.296616 0.581852
+ACCGTA 53.061197 2.557338 1.433034 0.676052
+ACCGTC 46.959848 2.369622 1.713169 0.883681
+ACCGTG 52.008672 2.285494 1.536626 0.750667
+ACCGTT 49.39228 2.512012 1.716204 0.886031
+ACCTAA 64.924902 0.866024 0.757377 0.259755
+ACCTAC 60.685226 0.608564 0.676216 0.219141
+ACCTAG 64.514914 0.898742 0.713263 0.237394
+ACCTAT 62.732888 0.614947 0.782014 0.272532
+ACCTCA 60.428218 0.729376 0.725403 0.243481
+ACCTCC 58.342917 0.778745 0.726639 0.244103
+ACCTCG 60.548275 0.9872 0.740173 0.250955
+ACCTCT 59.700593 0.960171 0.737447 0.24957
+ACCTGA 56.413599 1.476738 1.005824 0.397538
+ACCTGC 51.416098 1.241451 1.342877 0.613267
+ACCTGG 56.894071 0.849652 0.854762 0.311432
+ACCTGT 54.915044 1.065472 1.168298 0.497652
+ACCTTA 51.39095 1.219868 1.163289 0.494455
+ACCTTC 45.829217 1.322568 1.497948 0.722504
+ACCTTG 50.601177 0.945624 1.134155 0.475997
+ACCTTT 47.031856 1.54477 1.389608 0.645555
+ACGAAA 70.125563 1.439064 1.215944 0.528404
+ACGAAC 63.819666 1.569949 1.125055 0.470279
+ACGAAG 70.485613 1.322583 1.214552 0.527496
+ACGAAT 68.19727 2.223263 1.440929 0.681646
+ACGACA 62.223718 0.928997 0.698551 0.230087
+ACGACC 58.698152 0.891737 0.806253 0.285301
+ACGACG 61.684743 0.837478 0.742249 0.252011
+ACGACT 60.629238 0.734465 0.849007 0.308292
+ACGAGA 68.413714 2.022029 1.038302 0.416947
+ACGAGC 61.885477 1.306673 1.075968 0.43984
+ACGAGG 67.254769 1.638955 1.038761 0.417223
+ACGAGT 65.332393 1.69601 1.383408 0.64124
+ACGATA 59.325798 1.226254 1.044439 0.420649
+ACGATC 54.587755 1.829623 1.476683 0.707174
+ACGATG 58.483308 1.318694 1.113089 0.462797
+ACGATT 56.221056 1.756417 1.357295 0.62317
+ACGCAA 70.0182 1.114847 1.184177 0.507832
+ACGCAC 67.110596 1.350489 1.06055 0.430419
+ACGCAG 70.962988 0.918118 1.089752 0.448318
+ACGCAT 69.681543 1.270799 1.395588 0.649727
+ACGCCA 66.399675 0.811438 0.717992 0.239759
+ACGCCC 64.119466 0.928066 0.699819 0.230714
+ACGCCG 66.300626 0.738723 0.743916 0.25286
+ACGCCT 65.665682 0.840963 0.854558 0.31132
+ACGCGA 70.177026 1.067077 0.973831 0.378722
+ACGCGC 66.022805 1.361942 0.987031 0.386449
+ACGCGG 68.961306 0.985626 1.174013 0.501308
+ACGCGT 67.110817 1.004025 1.603312 0.800059
+ACGCTA 64.243503 1.454329 0.899174 0.336017
+ACGCTC 60.300003 1.408738 1.002886 0.395797
+ACGCTG 63.011018 1.566535 1.044601 0.420747
+ACGCTT 61.387322 2.56657 1.33014 0.604563
+ACGGAA 68.73319 2.132405 1.205383 0.521534
+ACGGAC 60.058269 0.983574 0.90662 0.340199
+ACGGAG 67.746815 2.035723 1.184871 0.508278
+ACGGAT 65.565851 1.354133 1.208255 0.523399
+ACGGCA 63.275975 2.446917 1.212579 0.526211
+ACGGCC 58.534629 1.51178 0.975823 0.379885
+ACGGCG 62.470142 2.322419 1.166135 0.496271
+ACGGCT 62.527858 2.459781 1.125892 0.470804
+ACGGGA 61.852768 1.255245 1.145215 0.482976
+ACGGGC 55.288166 1.363053 1.51849 0.737417
+ACGGGG 61.054444 1.290822 0.973987 0.378813
+ACGGGT 60.480044 1.167395 1.034298 0.414537
+ACGGTA 52.987022 1.129697 1.288589 0.576457
+ACGGTC 46.941829 1.366311 1.667414 0.848517
+ACGGTG 52.054583 1.144105 1.238722 0.543321
+ACGGTT 48.690358 1.585976 1.584475 0.786002
+ACGTAA 55.506139 1.569737 1.098334 0.453625
+ACGTAC 51.26218 1.02977 1.107856 0.459537
+ACGTAG 55.404004 1.537782 1.088651 0.44764
+ACGTAT 53.251863 1.349597 1.0848 0.445266
+ACGTCA 48.383661 1.813668 1.510279 0.731444
+ACGTCC 45.848718 1.34372 1.354893 0.621517
+ACGTCG 48.036096 1.568873 1.409428 0.659416
+ACGTCT 47.519613 1.746938 1.303219 0.586302
+ACGTGA 50.40295 0.902558 1.216554 0.528801
+ACGTGC 46.669776 0.881539 1.406346 0.657255
+ACGTGG 49.8776 0.965475 1.052413 0.425475
+ACGTGT 48.957452 0.882607 1.043176 0.419886
+ACGTTA 45.745203 0.912454 1.241699 0.54528
+ACGTTC 42.045398 0.888103 1.344252 0.614209
+ACGTTG 44.907925 0.787533 1.023378 0.40799
+ACGTTT 42.882286 0.716254 1.014836 0.402892
+ACTAAA 66.140651 0.827302 0.830792 0.298424
+ACTAAC 61.224659 1.279212 0.80203 0.283062
+ACTAAG 67.076229 0.858153 0.886447 0.328908
+ACTAAT 65.300633 1.035987 1.040867 0.418493
+ACTACA 63.3609 1.153889 0.757984 0.260067
+ACTACC 60.567476 0.805761 0.65673 0.209737
+ACTACG 63.099219 1.016744 0.728511 0.245047
+ACTACT 62.448624 0.850221 0.769674 0.266107
+ACTAGA 66.311565 0.807959 0.923212 0.349581
+ACTAGC 61.420573 1.310442 0.844676 0.305936
+ACTAGG 66.062611 0.610638 0.868216 0.318814
+ACTAGT 64.565114 0.671549 1.262163 0.558815
+ACTATA 61.037145 1.349725 0.735368 0.248515
+ACTATC 57.064744 1.459399 0.938895 0.358526
+ACTATG 59.762098 1.185252 0.82719 0.296485
+ACTATT 57.895404 1.427562 1.049622 0.423784
+ACTCAA 65.79458 0.970519 0.914039 0.344384
+ACTCAC 63.242341 0.761522 0.740194 0.250965
+ACTCAG 66.967691 1.073824 1.076738 0.440312
+ACTCAT 65.640981 0.950251 1.059153 0.429569
+ACTCCA 62.81328 1.780677 0.992274 0.389532
+ACTCCC 61.169584 1.071807 0.812827 0.288797
+ACTCCG 62.874473 1.397075 0.96304 0.372445
+ACTCCT 62.37865 1.263521 0.928109 0.352366
+ACTCGA 66.075145 1.080908 0.938357 0.358218
+ACTCGC 62.856392 0.783889 0.728408 0.244995
+ACTCGG 65.354131 1.072071 0.951803 0.365945
+ACTCGT 63.943999 1.240358 1.461499 0.696295
+ACTCTA 61.122971 0.758066 0.685305 0.223574
+ACTCTC 58.498827 1.098221 0.688132 0.224959
+ACTCTG 60.214593 0.719498 0.847145 0.307278
+ACTCTT 58.766508 1.132953 1.123065 0.469032
+ACTGAA 63.422167 1.991085 1.230472 0.537902
+ACTGAC 56.02835 1.451813 0.862776 0.315822
+ACTGAG 62.467647 2.61176 1.187594 0.510032
+ACTGAT 60.585116 1.863706 1.172502 0.500341
+ACTGCA 58.725369 2.61176 1.403716 0.655411
+ACTGCC 55.0016 1.941655 1.178093 0.503924
+ACTGCG 57.763208 2.61176 1.367389 0.630134
+ACTGCT 56.988204 2.191996 1.254083 0.553458
+ACTGGA 60.222277 1.303411 1.019147 0.405462
+ACTGGC 55.466997 0.733457 0.927686 0.352125
+ACTGGG 59.283728 1.226532 0.854756 0.311429
+ACTGGT 58.553274 0.937201 0.932223 0.354711
+ACTGTA 51.733157 0.96464 0.913491 0.344074
+ACTGTC 46.36146 1.450432 1.119875 0.467035
+ACTGTG 50.804337 1.28275 0.901683 0.337424
+ACTGTT 47.957616 1.350826 1.064641 0.432913
+ACTTAA 57.440943 1.731343 1.097144 0.452888
+ACTTAC 53.85301 1.360809 0.890267 0.331036
+ACTTAG 56.964335 1.195813 1.08151 0.443242
+ACTTAT 55.964281 1.866799 0.932719 0.354994
+ACTTCA 51.083323 2.06684 1.336548 0.608936
+ACTTCC 48.881 1.937535 1.237258 0.542357
+ACTTCG 50.978921 1.900897 1.319903 0.597597
+ACTTCT 50.07115 1.945251 1.103744 0.45698
+ACTTGA 52.410951 1.005246 1.042012 0.419184
+ACTTGC 48.680781 0.663905 1.071727 0.437242
+ACTTGG 52.081089 1.077153 0.914886 0.344862
+ACTTGT 51.394335 0.988105 0.805346 0.284819
+ACTTTA 47.28822 0.928762 1.00986 0.399933
+ACTTTC 43.618669 0.866205 1.044888 0.42092
+ACTTTG 46.668912 0.819603 0.853059 0.310501
+ACTTTT 44.55385 0.705555 0.804076 0.284146
+AGAAAA 65.310254 0.96192 0.886121 0.328727
+AGAAAC 60.721111 1.645997 1.151565 0.486999
+AGAAAG 65.471139 1.022228 0.901605 0.33738
+AGAAAT 63.878522 1.456838 1.256486 0.55505
+AGAACA 57.953989 0.982225 1.070694 0.436609
+AGAACC 55.20037 0.944964 1.169627 0.498502
+AGAACG 57.464766 1.14271 1.008548 0.399154
+AGAACT 56.901973 0.804478 0.935884 0.356803
+AGAAGA 64.947684 1.113278 0.941969 0.360288
+AGAAGC 60.922017 1.282165 1.276762 0.568539
+AGAAGG 64.162612 1.09012 0.982639 0.383872
+AGAAGT 62.934256 1.466072 1.450256 0.688275
+AGAATA 57.865102 1.196087 1.209924 0.524484
+AGAATC 54.651276 1.71439 1.628432 0.818936
+AGAATG 57.296294 1.540684 1.322675 0.59948
+AGAATT 55.490813 2.028972 1.589098 0.789444
+AGACAA 64.015667 0.936371 0.743679 0.25274
+AGACAC 61.863285 0.983774 0.697192 0.229416
+AGACAG 64.406395 1.436844 0.842075 0.304524
+AGACAT 63.833236 0.937783 0.787863 0.275595
+AGACCA 58.961781 1.266722 0.802161 0.283131
+AGACCC 56.935243 0.670583 0.882218 0.326557
+AGACCG 59.190935 1.599756 0.835258 0.300834
+AGACCT 59.040176 1.701478 0.778811 0.270859
+AGACGA 62.997747 1.091392 0.78296 0.273027
+AGACGC 63.000746 2.540478 0.877108 0.323724
+AGACGG 62.237996 1.266533 0.802061 0.283078
+AGACGT 61.211928 1.095093 1.010445 0.40028
+AGACTA 58.980066 0.613033 0.69411 0.227897
+AGACTC 56.428795 0.637913 0.773216 0.267946
+AGACTG 58.076861 0.685278 0.722926 0.242235
+AGACTT 56.804618 0.783772 1.003136 0.395945
+AGAGAA 70.438349 2.082183 1.112389 0.46236
+AGAGAC 63.213643 1.013977 0.943152 0.360967
+AGAGAG 68.948438 1.481669 1.106672 0.458801
+AGAGAT 66.64366 1.254695 1.123885 0.469546
+AGAGCA 62.793457 1.560271 1.019768 0.405833
+AGAGCC 59.467438 0.985089 0.882164 0.326527
+AGAGCG 62.839288 2.163 0.976009 0.379993
+AGAGCT 62.538191 1.985493 0.952295 0.366229
+AGAGGA 65.965973 1.098807 0.980818 0.382805
+AGAGGC 61.00258 1.035775 1.072973 0.438004
+AGAGGG 64.47811 0.915137 0.848313 0.307914
+AGAGGT 64.234677 1.239064 1.086722 0.44645
+AGAGTA 57.140833 1.348256 1.14081 0.480192
+AGAGTC 52.053498 1.590395 1.543275 0.755545
+AGAGTG 56.433913 1.284088 1.239278 0.543686
+AGAGTT 53.730942 1.693917 1.533538 0.748406
+AGATAA 58.85966 1.14934 0.806331 0.285342
+AGATAC 55.55706 0.876471 0.876574 0.323429
+AGATAG 58.635405 1.278756 0.852571 0.310235
+AGATAT 57.67885 1.053538 0.821353 0.293353
+AGATCA 52.928994 0.999027 1.050113 0.424081
+AGATCC 50.766551 1.060462 1.141267 0.480481
+AGATCG 52.687987 1.256381 1.075372 0.439474
+AGATCT 52.018896 0.876794 0.872577 0.321219
+AGATGA 55.01015 0.919318 1.03654 0.415886
+AGATGC 51.167819 1.02466 1.29813 0.582871
+AGATGG 54.61196 0.919419 0.948355 0.363958
+AGATGT 53.313775 0.689989 0.958017 0.369535
+AGATTA 50.016438 0.864964 1.224561 0.53403
+AGATTC 46.19177 1.109951 1.366691 0.629652
+AGATTG 49.271986 0.831771 1.001133 0.39476
+AGATTT 46.939415 1.084153 1.215365 0.528026
+AGCAAA 65.25709 1.097902 0.905615 0.339634
+AGCAAC 61.180714 1.638249 1.066433 0.434006
+AGCAAG 65.934009 0.770197 0.910854 0.342585
+AGCAAT 64.528105 1.124724 1.225146 0.534413
+AGCACA 63.460815 0.851654 0.782104 0.272579
+AGCACC 61.059922 0.742382 0.824063 0.294806
+AGCACG 62.99381 0.753864 0.818114 0.291619
+AGCACT 62.630524 0.736689 0.905554 0.339599
+AGCAGA 66.591206 1.158229 0.892635 0.332358
+AGCAGC 62.757726 1.590065 1.035485 0.415251
+AGCAGG 66.232672 1.005881 0.922513 0.349184
+AGCAGT 65.413467 1.640055 1.521171 0.739371
+AGCATA 62.648063 1.101386 0.912138 0.34331
+AGCATC 58.992095 1.859163 1.145979 0.483459
+AGCATG 61.788697 1.508765 1.087283 0.446796
+AGCATT 60.193402 2.508267 1.358101 0.623725
+AGCCAA 66.906513 0.918113 0.825745 0.295709
+AGCCAC 64.41176 0.834805 0.732243 0.246932
+AGCCAG 67.548705 1.005811 0.857113 0.312717
+AGCCAT 66.787032 0.886119 0.945896 0.362544
+AGCCCA 64.302208 1.020258 0.771599 0.267105
+AGCCCC 62.424795 0.975037 0.716323 0.238923
+AGCCCG 63.973145 1.054128 0.757093 0.259609
+AGCCCT 63.692675 0.86154 0.774624 0.268678
+AGCCGA 66.681955 1.126604 0.791198 0.277347
+AGCCGC 64.574768 0.997646 0.724242 0.242896
+AGCCGG 66.414114 1.017548 0.840789 0.303827
+AGCCGT 65.079655 0.970275 1.303861 0.586735
+AGCCTA 62.702129 1.985229 0.715728 0.238626
+AGCCTC 61.034922 1.69432 0.757227 0.259677
+AGCCTG 62.170837 0.954195 0.86817 0.318788
+AGCCTT 60.438883 1.255189 1.203257 0.520155
+AGCGAA 69.709758 1.410893 0.902611 0.337945
+AGCGAC 64.067826 0.992139 0.887876 0.329703
+AGCGAG 69.026881 1.250846 0.87265 0.321259
+AGCGAT 67.141466 1.101949 1.187194 0.509774
+AGCGCA 66.1727 1.837514 0.934588 0.356062
+AGCGCC 62.627849 0.854109 0.725533 0.243546
+AGCGCG 65.592983 1.769196 0.925427 0.350839
+AGCGCT 64.942225 1.467283 0.914255 0.344506
+AGCGGA 64.795098 1.279519 0.914399 0.344587
+AGCGGC 59.389318 1.271991 1.177316 0.503425
+AGCGGG 63.801438 1.354161 0.986198 0.385959
+AGCGGT 62.713738 1.369301 1.281164 0.571482
+AGCGTA 54.733505 2.24365 1.284073 0.573429
+AGCGTC 48.632371 2.507098 1.669157 0.849848
+AGCGTG 53.69239 2.018203 1.407105 0.657787
+AGCGTT 50.824454 2.172384 1.606676 0.802579
+AGCTAA 63.614672 1.396391 0.780374 0.271675
+AGCTAC 59.429959 0.678969 0.712494 0.23701
+AGCTAG 62.866437 1.822225 0.856396 0.312325
+AGCTAT 61.304634 0.729721 0.770792 0.266686
+AGCTCA 58.40307 0.992783 0.780573 0.271779
+AGCTCC 56.413654 0.951126 0.929541 0.353182
+AGCTCG 58.33961 0.806999 0.835491 0.300959
+AGCTCT 57.593709 0.960885 0.742085 0.251928
+AGCTGA 56.358371 1.16261 0.982218 0.383625
+AGCTGC 51.700299 1.201946 1.329015 0.603796
+AGCTGG 56.602602 0.829217 0.879937 0.325291
+AGCTGT 54.889013 0.941725 1.101875 0.45582
+AGCTTA 51.515764 1.101114 1.173262 0.500827
+AGCTTC 46.688556 1.172841 1.54546 0.75715
+AGCTTG 50.730991 1.132588 1.136645 0.477565
+AGCTTT 47.763696 1.428061 1.43232 0.675547
+AGGAAA 74.829111 1.980573 1.610691 0.805589
+AGGAAC 69.163335 1.840857 1.418396 0.66572
+AGGAAG 75.235331 1.856998 1.54453 0.756466
+AGGAAT 73.250625 2.049058 1.84687 0.989122
+AGGACA 63.972973 1.049519 0.884923 0.32806
+AGGACC 59.706059 0.973343 0.911645 0.343031
+AGGACG 62.912862 0.853389 0.900049 0.336508
+AGGACT 61.961514 0.864929 0.953485 0.366916
+AGGAGA 73.186655 1.738732 1.514999 0.734875
+AGGAGC 67.32505 1.827305 1.368764 0.631085
+AGGAGG 72.433368 2.289827 1.494108 0.719728
+AGGAGT 70.366128 2.268253 1.663306 0.845383
+AGGATA 62.703958 1.553452 1.153927 0.488498
+AGGATC 58.113791 1.998088 1.511588 0.732395
+AGGATG 61.803857 1.679403 1.31144 0.591858
+AGGATT 60.134742 2.61176 1.714913 0.885031
+AGGCAA 72.022037 1.32261 1.341626 0.61241
+AGGCAC 69.356226 1.23492 1.197125 0.516184
+AGGCAG 72.309735 1.199573 1.162386 0.493879
+AGGCAT 71.468476 1.339134 1.492344 0.718453
+AGGCCA 66.371092 1.062885 0.84446 0.305819
+AGGCCC 64.095862 0.995718 0.818109 0.291617
+AGGCCG 66.00306 0.951195 0.838595 0.302638
+AGGCCT 65.469832 0.792281 0.889569 0.330647
+AGGCGA 71.651265 1.035765 1.173403 0.500917
+AGGCGC 67.943656 1.20485 1.14055 0.480029
+AGGCGG 70.124772 1.154074 1.287987 0.576053
+AGGCGT 68.59356 1.15999 1.769456 0.927588
+AGGCTA 66.155561 1.106559 1.019529 0.40569
+AGGCTC 62.551576 1.385209 1.229264 0.537109
+AGGCTG 65.132869 1.211984 1.270654 0.564464
+AGGCTT 64.268577 1.641748 1.505404 0.727905
+AGGGAA 75.140877 2.10307 1.525349 0.742419
+AGGGAC 66.92062 0.883384 1.08842 0.447497
+AGGGAG 74.031133 1.911036 1.438774 0.680118
+AGGGAT 71.499091 1.681701 1.528311 0.744583
+AGGGCA 67.791061 2.61176 1.288157 0.576167
+AGGGCC 62.799965 2.140659 0.988915 0.387555
+AGGGCG 66.283077 2.21122 1.170095 0.498801
+AGGGCT 66.345149 1.927656 1.199554 0.517756
+AGGGGA 69.796907 1.204511 1.158968 0.491703
+AGGGGC 63.743936 1.576506 1.036483 0.415852
+AGGGGG 68.780265 1.277784 1.139279 0.479226
+AGGGGT 67.937643 1.258602 1.286056 0.574758
+AGGGTA 60.768379 1.342803 1.038514 0.417075
+AGGGTC 55.501722 1.809356 1.407865 0.65832
+AGGGTG 59.961971 1.388244 1.151599 0.48702
+AGGGTT 56.759548 1.909974 1.411671 0.660991
+AGGTAA 60.696625 1.355886 0.917408 0.346289
+AGGTAC 56.500483 0.777556 0.921919 0.348847
+AGGTAG 60.718077 1.474773 0.929357 0.353077
+AGGTAT 58.705106 1.012794 0.897911 0.335309
+AGGTCA 52.743518 1.176256 1.131807 0.474519
+AGGTCC 50.269847 0.904776 1.109808 0.460752
+AGGTCG 52.478214 1.210785 1.132556 0.47499
+AGGTCT 51.27084 1.122552 1.05297 0.425814
+AGGTGA 56.326715 0.886397 0.957932 0.369486
+AGGTGC 52.271405 0.893399 1.084238 0.44492
+AGGTGG 55.918121 1.023955 0.934401 0.355955
+AGGTGT 54.486076 0.781068 0.93667 0.357252
+AGGTTA 50.239919 0.825904 1.0235 0.408063
+AGGTTC 46.625456 1.169555 1.276912 0.568639
+AGGTTG 49.64092 0.897123 0.952923 0.366591
+AGGTTT 47.37511 1.102955 1.178015 0.503873
+AGTAAA 64.278993 0.938601 0.923494 0.349741
+AGTAAC 60.642902 0.69666 0.788603 0.275983
+AGTAAG 64.764875 1.04073 0.955355 0.367995
+AGTAAT 63.564215 0.892649 1.04739 0.422433
+AGTACA 60.343203 1.430484 1.035426 0.415216
+AGTACC 57.958232 0.970589 0.799704 0.281831
+AGTACG 59.922073 1.48725 0.95952 0.370404
+AGTACT 59.647168 1.645101 0.896595 0.334572
+AGTAGA 64.135861 1.126879 0.937941 0.35798
+AGTAGC 60.755819 0.777983 0.861142 0.314925
+AGTAGG 63.466612 0.998103 0.911875 0.343161
+AGTAGT 62.472699 1.089445 1.215596 0.528177
+AGTATA 59.297543 0.646542 0.720781 0.241157
+AGTATC 56.339726 1.074528 0.850133 0.308905
+AGTATG 58.625409 1.047705 0.865376 0.317251
+AGTATT 57.321139 1.261455 1.054295 0.426617
+AGTCAA 62.225388 1.659101 1.183036 0.507098
+AGTCAC 60.107482 0.955385 0.881026 0.325895
+AGTCAG 62.138307 1.80849 1.452664 0.68999
+AGTCAT 62.179238 1.446083 1.186407 0.509267
+AGTCCA 57.965966 1.775734 1.290125 0.577488
+AGTCCC 56.532955 1.398551 1.244207 0.546933
+AGTCCG 57.781757 1.87999 1.213492 0.526806
+AGTCCT 57.122196 1.587626 1.143919 0.482157
+AGTCGA 61.430169 1.869843 1.338842 0.610505
+AGTCGC 59.196725 1.128424 1.063551 0.432248
+AGTCGG 60.597572 1.686839 1.301929 0.585432
+AGTCGT 59.981766 1.491742 1.431882 0.675237
+AGTCTA 57.508547 1.179944 0.989751 0.388047
+AGTCTC 55.264284 0.75925 0.763908 0.263122
+AGTCTG 56.755415 1.002074 0.945838 0.36251
+AGTCTT 55.649538 0.899455 0.955758 0.368229
+AGTGAA 62.665565 2.61176 1.314994 0.594266
+AGTGAC 56.452418 1.538359 0.854621 0.311355
+AGTGAG 61.629396 2.61176 1.264221 0.560183
+AGTGAT 60.445818 1.950074 1.304019 0.586842
+AGTGCA 57.8253 2.61176 1.390449 0.646142
+AGTGCC 54.853898 2.05869 1.204593 0.521021
+AGTGCG 57.072647 2.497982 1.366163 0.629287
+AGTGCT 56.757893 2.61176 1.225791 0.534835
+AGTGGA 59.965183 1.254005 1.14968 0.485803
+AGTGGC 55.995044 0.83929 0.882238 0.326568
+AGTGGG 59.088145 1.314388 1.014938 0.402953
+AGTGGT 58.566572 1.223567 1.079387 0.441938
+AGTGTA 53.200142 0.992212 0.832023 0.299087
+AGTGTC 47.912402 1.163013 0.994746 0.390988
+AGTGTG 51.902168 1.117386 0.829838 0.29791
+AGTGTT 49.540842 1.190151 0.915536 0.34523
+AGTTAA 56.365287 1.80769 1.125794 0.470743
+AGTTAC 53.092346 1.285533 0.912602 0.343572
+AGTTAG 56.022272 2.278134 1.090504 0.448783
+AGTTAT 54.852754 1.497444 0.990305 0.388373
+AGTTCA 49.96367 1.94389 1.226626 0.535382
+AGTTCC 47.831618 1.516494 1.212104 0.525903
+AGTTCG 50.02544 2.010273 1.136026 0.477175
+AGTTCT 49.391989 1.773228 0.996877 0.392245
+AGTTGA 51.811415 1.12193 1.059514 0.429789
+AGTTGC 48.781223 0.899245 1.069953 0.436156
+AGTTGG 51.745125 1.219836 0.894479 0.333388
+AGTTGT 50.812997 0.975437 0.809131 0.286829
+AGTTTA 47.401994 0.955046 1.085628 0.445776
+AGTTTC 43.958129 0.683711 0.857308 0.312824
+AGTTTG 46.678485 0.826966 0.798555 0.281224
+AGTTTT 44.8843 0.703347 0.701876 0.231732
+ATAAAA 64.32792 1.010643 0.80746 0.285941
+ATAAAC 59.30963 1.135371 0.833554 0.299913
+ATAAAG 64.34739 1.002001 0.765831 0.264116
+ATAAAT 62.778708 0.95303 0.987863 0.386937
+ATAACA 58.760148 0.973465 0.739531 0.250628
+ATAACC 56.145755 0.785003 0.820189 0.292729
+ATAACG 58.311193 0.757954 0.748089 0.254991
+ATAACT 57.79122 0.706728 0.693728 0.227708
+ATAAGA 64.959129 1.118716 0.825285 0.295462
+ATAAGC 60.194723 1.02589 0.902629 0.337955
+ATAAGG 63.949254 0.992322 0.861021 0.314859
+ATAAGT 62.740514 1.067595 1.157235 0.4906
+ATAATA 58.06774 1.026477 0.852527 0.310211
+ATAATC 54.644 1.67883 1.128094 0.472186
+ATAATG 57.316424 1.332527 0.990765 0.388643
+ATAATT 56.176533 1.695792 1.139949 0.479649
+ATACAA 66.354515 0.969891 0.864472 0.316754
+ATACAC 63.724005 1.076074 0.763967 0.263152
+ATACAG 66.976329 1.015293 0.9772 0.380689
+ATACAT 65.933603 0.98729 1.006173 0.397745
+ATACCA 62.148658 1.144391 0.843047 0.305051
+ATACCC 60.38508 0.975112 0.760073 0.261143
+ATACCG 61.976269 1.165763 0.799176 0.281552
+ATACCT 61.704952 1.142632 0.809554 0.287054
+ATACGA 65.77991 1.242734 0.877054 0.323694
+ATACGC 62.641811 0.777665 0.759356 0.260774
+ATACGG 64.906559 1.091893 0.937427 0.357686
+ATACGT 63.578761 1.091379 1.295782 0.581291
+ATACTA 61.644473 1.088641 0.718615 0.240071
+ATACTC 58.763041 1.6331 0.702482 0.232032
+ATACTG 60.286836 1.263291 0.892411 0.332233
+ATACTT 58.767661 1.224791 1.089027 0.447871
+ATAGAA 67.855314 1.757886 1.007745 0.398677
+ATAGAC 61.376969 0.834876 0.754737 0.258398
+ATAGAG 67.406405 1.995501 0.967492 0.37503
+ATAGAT 65.533855 1.648859 1.099677 0.454457
+ATAGCA 63.011064 1.704997 0.963248 0.372565
+ATAGCC 59.256474 0.906568 0.757983 0.260067
+ATAGCG 62.836549 1.970497 0.959966 0.370663
+ATAGCT 62.208733 1.615242 0.935979 0.356857
+ATAGGA 64.443207 0.709293 0.884656 0.327912
+ATAGGC 59.499132 1.060619 1.050363 0.424233
+ATAGGG 63.860365 1.207584 0.864247 0.31663
+ATAGGT 62.552416 0.884035 0.932353 0.354785
+ATAGTA 55.492525 0.874745 1.021935 0.407127
+ATAGTC 50.322459 1.746044 1.353831 0.620786
+ATAGTG 54.654795 1.117948 0.995861 0.391646
+ATAGTT 51.814133 1.618014 1.258964 0.556693
+ATATAA 60.726244 1.019404 0.663518 0.212997
+ATATAC 56.882935 0.617723 0.668782 0.215537
+ATATAG 60.635173 1.273673 0.695026 0.228348
+ATATAT 58.929807 0.933738 0.68324 0.222564
+ATATCA 54.984568 0.959602 0.836461 0.301483
+ATATCC 52.989419 0.89344 0.915373 0.345138
+ATATCG 55.054589 1.044565 0.848982 0.308278
+ATATCT 53.990056 0.775433 0.728828 0.245207
+ATATGA 55.681707 0.948017 0.896921 0.334755
+ATATGC 51.19955 1.018915 1.256697 0.555189
+ATATGG 55.410067 0.732063 0.774948 0.268847
+ATATGT 53.792112 0.703091 0.897154 0.334885
+ATATTA 50.565368 0.961139 1.134138 0.475986
+ATATTC 46.039743 1.105085 1.308229 0.589686
+ATATTG 49.72158 0.815464 0.952266 0.366212
+ATATTT 47.03578 1.190663 1.181448 0.506078
+ATCAAA 64.178302 1.294502 0.93994 0.359125
+ATCAAC 59.617761 1.091228 0.927629 0.352093
+ATCAAG 64.815783 0.869032 0.923112 0.349524
+ATCAAT 63.385177 0.841955 1.094046 0.450971
+ATCACA 63.045255 0.97473 0.795274 0.279493
+ATCACC 60.691971 0.781075 0.774431 0.268577
+ATCACG 62.689071 0.877405 0.768874 0.265692
+ATCACT 62.179757 0.796702 0.806266 0.285307
+ATCAGA 66.074703 1.17942 0.987052 0.38646
+ATCAGC 62.739426 2.014236 0.984591 0.385016
+ATCAGG 65.658814 0.934628 0.984117 0.384738
+ATCAGT 64.689922 1.186498 1.450223 0.688252
+ATCATA 62.378298 1.241312 0.85805 0.313231
+ATCATC 58.58917 1.416493 1.024142 0.408447
+ATCATG 61.42049 1.525939 1.046701 0.422016
+ATCATT 59.817383 2.069396 1.23115 0.538346
+ATCCAA 66.515565 1.102579 1.03376 0.414214
+ATCCAC 64.112225 1.022648 0.798517 0.281204
+ATCCAG 67.840764 1.25075 1.094101 0.451005
+ATCCAT 66.810178 0.934839 1.142214 0.481079
+ATCCCA 64.551881 1.392257 1.001016 0.394691
+ATCCCC 62.748169 0.93469 0.890524 0.33118
+ATCCCG 64.392683 1.586179 1.137938 0.47838
+ATCCCT 64.302171 1.213559 0.998713 0.39333
+ATCCGA 67.343779 1.147651 1.121134 0.467823
+ATCCGC 64.1435 0.857869 0.846603 0.306984
+ATCCGG 66.536251 1.162177 1.140504 0.479999
+ATCCGT 65.239991 1.217137 1.534246 0.748924
+ATCCTA 63.240803 0.879456 0.748776 0.255342
+ATCCTC 60.574562 1.409657 0.871893 0.320841
+ATCCTG 62.12282 0.960501 1.002394 0.395506
+ATCCTT 60.60007 1.274415 1.192395 0.513128
+ATCGAA 68.667479 1.412118 1.17952 0.50484
+ATCGAC 63.098265 0.909718 0.842324 0.304659
+ATCGAG 68.409643 1.366658 1.163438 0.49455
+ATCGAT 66.209008 0.998577 1.153093 0.487968
+ATCGCA 65.216744 1.629605 1.032126 0.413232
+ATCGCC 62.4162 1.050942 0.73117 0.24639
+ATCGCG 64.934127 1.7498 1.02789 0.410691
+ATCGCT 64.615394 1.281034 1.037462 0.416441
+ATCGGA 64.15103 1.065127 1.016439 0.403847
+ATCGGC 58.544056 1.41539 1.093713 0.450765
+ATCGGG 63.476064 1.341909 0.976564 0.380317
+ATCGGT 62.156352 1.53375 1.244769 0.547304
+ATCGTA 53.851771 2.202613 1.279223 0.570184
+ATCGTC 47.617425 2.174275 1.537437 0.751262
+ATCGTG 52.993517 2.111844 1.32736 0.602668
+ATCGTT 49.583819 2.169263 1.509277 0.730716
+ATCTAA 63.129039 0.901227 0.79665 0.280218
+ATCTAC 59.212338 0.781181 0.706538 0.234045
+ATCTAG 62.829294 1.859736 0.841042 0.303964
+ATCTAT 61.357864 0.839508 0.830191 0.2981
+ATCTCA 59.087662 1.3037 0.809704 0.287134
+ATCTCC 56.701023 0.879321 0.697095 0.229368
+ATCTCG 58.891827 1.236789 0.799048 0.281484
+ATCTCT 57.90037 0.947457 0.721093 0.241314
+ATCTGA 56.044828 1.378994 0.891751 0.331865
+ATCTGC 50.963436 1.056736 1.105386 0.458001
+ATCTGG 56.408138 0.930869 0.788787 0.27608
+ATCTGT 54.355977 0.947217 0.952279 0.366219
+ATCTTA 50.870021 1.020393 0.937178 0.357543
+ATCTTC 45.794625 1.125354 1.252036 0.552103
+ATCTTG 50.148997 0.972746 0.866255 0.317734
+ATCTTT 46.756096 1.234848 1.082751 0.444005
+ATGAAA 70.205601 1.221946 1.423668 0.669435
+ATGAAC 64.432638 1.878857 1.324145 0.60048
+ATGAAG 70.505849 1.29743 1.500398 0.724278
+ATGAAT 68.578228 1.454986 1.570763 0.775821
+ATGACA 61.341042 1.010145 0.813227 0.28901
+ATGACC 58.195531 0.898702 0.807683 0.28606
+ATGACG 60.767903 0.935796 0.827605 0.296708
+ATGACT 60.298804 0.821735 0.847447 0.307442
+ATGAGA 68.70767 1.392303 1.229429 0.537218
+ATGAGC 63.166809 1.497454 1.244534 0.547149
+ATGAGG 67.578899 1.03509 1.276589 0.568423
+ATGAGT 66.028248 1.076173 1.572269 0.776937
+ATGATA 60.012898 1.510626 1.084495 0.445079
+ATGATC 55.408427 1.561555 1.209134 0.523971
+ATGATG 59.105859 1.451489 1.179179 0.504621
+ATGATT 57.115022 2.2627 1.3616 0.626137
+ATGCAA 69.562096 1.302393 1.358142 0.623754
+ATGCAC 66.636991 1.203684 1.157786 0.490951
+ATGCAG 70.212562 1.266581 1.445582 0.684951
+ATGCAT 69.035212 1.356266 1.550556 0.760898
+ATGCCA 65.112768 1.366405 1.089448 0.448131
+ATGCCC 63.153201 1.005528 0.926142 0.351246
+ATGCCG 64.78363 1.391205 1.131204 0.47414
+ATGCCT 64.645025 1.112813 1.082951 0.444128
+ATGCGA 69.576073 1.240296 1.290523 0.577756
+ATGCGC 65.519874 1.041151 1.070124 0.436261
+ATGCGG 67.869858 1.292644 1.494693 0.72015
+ATGCGT 66.382017 1.508859 1.816471 0.964802
+ATGCTA 64.36068 1.020291 0.979963 0.382305
+ATGCTC 60.89976 1.15976 1.206611 0.522331
+ATGCTG 62.961504 1.160487 1.307159 0.588963
+ATGCTT 61.876517 1.257935 1.536824 0.750812
+ATGGAA 69.543287 2.103536 1.54124 0.754051
+ATGGAC 61.237461 1.516677 0.885586 0.328429
+ATGGAG 68.257302 2.490609 1.517962 0.737032
+ATGGAT 66.177569 1.739708 1.378814 0.638049
+ATGGCA 63.353475 2.342763 1.238966 0.543481
+ATGGCC 59.58703 1.385388 0.908043 0.341
+ATGGCG 62.672828 2.357179 1.186526 0.509344
+ATGGCT 62.355343 2.136612 1.193111 0.51359
+ATGGGA 63.388164 1.416371 1.226626 0.535382
+ATGGGC 56.564882 0.998408 1.156423 0.490084
+ATGGGG 62.155147 1.272034 1.074693 0.439058
+ATGGGT 61.896414 1.243411 1.102466 0.456187
+ATGGTA 54.697527 0.909096 1.015978 0.403573
+ATGGTC 48.517384 1.014129 1.232679 0.53935
+ATGGTG 53.92999 0.984049 0.984582 0.385011
+ATGGTT 50.655197 1.182368 1.196434 0.515737
+ATGTAA 56.680512 1.384351 0.9719 0.377596
+ATGTAC 52.634694 1.102703 0.891703 0.331837
+ATGTAG 56.273958 1.731118 0.968368 0.37554
+ATGTAT 54.914695 1.560657 0.850952 0.309352
+ATGTCA 49.280676 1.684198 1.142179 0.481057
+ATGTCC 47.278068 1.892416 1.094465 0.45123
+ATGTCG 49.248704 1.67513 1.086623 0.446389
+ATGTCT 48.412128 1.38143 0.976239 0.380128
+ATGTGA 51.989958 0.912392 0.976574 0.380323
+ATGTGC 47.911823 0.737481 1.117057 0.465274
+ATGTGG 51.590035 1.095579 0.901779 0.337478
+ATGTGT 50.164961 0.815797 0.778998 0.270956
+ATGTTA 46.522037 0.749807 0.985845 0.385752
+ATGTTC 42.918332 0.744895 1.057737 0.428708
+ATGTTG 45.976396 0.683574 0.835747 0.301098
+ATGTTT 43.922368 0.803213 0.851972 0.309908
+ATTAAA 64.551246 0.930625 0.914337 0.344552
+ATTAAC 60.539483 0.842534 0.886784 0.329096
+ATTAAG 65.392245 1.035448 1.065486 0.433428
+ATTAAT 63.768614 1.071143 1.174011 0.501307
+ATTACA 61.322659 1.609828 1.043427 0.420038
+ATTACC 58.989835 1.148424 0.88881 0.330224
+ATTACG 60.992204 1.62837 1.060537 0.430412
+ATTACT 60.877676 1.317806 0.926138 0.351244
+ATTAGA 64.323355 0.952286 0.942882 0.360813
+ATTAGC 60.691213 0.800046 0.953633 0.367001
+ATTAGG 64.165783 0.942116 0.969373 0.376124
+ATTAGT 62.793178 1.141758 1.360487 0.62537
+ATTATA 59.918478 0.766054 0.786075 0.274657
+ATTATC 56.425024 1.113314 0.977644 0.380949
+ATTATG 59.13057 0.848218 0.93467 0.356109
+ATTATT 57.310472 1.43629 1.162752 0.494113
+ATTCAA 63.703715 1.424786 1.191694 0.512675
+ATTCAC 61.27407 0.95624 0.978977 0.381728
+ATTCAG 64.287523 1.899729 1.482637 0.711455
+ATTCAT 63.763436 1.316386 1.341747 0.612493
+ATTCCA 60.437611 2.051271 1.52487 0.742069
+ATTCCC 58.369192 1.486152 1.288949 0.576698
+ATTCCG 60.048124 1.93843 1.478657 0.708592
+ATTCCT 59.39255 1.94035 1.282699 0.572509
+ATTCGA 63.431022 1.772311 1.406859 0.657614
+ATTCGC 60.810455 1.073165 1.054926 0.427
+ATTCGG 62.731355 1.721595 1.453034 0.690254
+ATTCGT 61.436772 1.726056 1.501318 0.724944
+ATTCTA 58.988278 1.227795 0.951977 0.366046
+ATTCTC 56.643281 0.829165 0.802646 0.283388
+ATTCTG 58.214264 1.033582 0.99496 0.391114
+ATTCTT 56.480109 1.128736 1.252552 0.552445
+ATTGAA 62.363236 2.61176 1.379769 0.638712
+ATTGAC 56.310521 1.455209 0.880226 0.325452
+ATTGAG 61.162326 2.557362 1.416399 0.664315
+ATTGAT 60.398683 2.019174 1.315216 0.594417
+ATTGCA 58.241831 2.61176 1.44303 0.683138
+ATTGCC 55.563731 2.012156 1.179659 0.504928
+ATTGCG 57.897146 2.439547 1.333232 0.606672
+ATTGCT 57.386837 2.570502 1.244217 0.54694
+ATTGGA 59.901346 1.686903 1.212297 0.526028
+ATTGGC 55.51536 0.834819 1.069807 0.436067
+ATTGGG 58.746841 1.26186 1.121247 0.467894
+ATTGGT 58.39007 1.167267 1.060076 0.430131
+ATTGTA 52.288938 0.990555 0.858358 0.313399
+ATTGTC 46.715783 1.161232 1.010416 0.400263
+ATTGTG 51.589093 1.263334 0.840162 0.303487
+ATTGTT 48.563739 1.444192 0.908528 0.341274
+ATTTAA 57.155199 2.145391 1.319046 0.597015
+ATTTAC 53.49361 1.233884 1.004634 0.396832
+ATTTAG 56.171573 1.987052 1.168136 0.497549
+ATTTAT 55.320416 1.671724 1.091886 0.449636
+ATTTCA 51.167775 2.167699 1.137887 0.478348
+ATTTCC 48.784773 1.670477 1.158209 0.491219
+ATTTCG 51.004858 2.074658 1.159868 0.492275
+ATTTCT 49.948132 1.851133 1.008475 0.39911
+ATTTGA 52.252307 1.112757 1.119984 0.467103
+ATTTGC 48.641449 0.784062 1.043324 0.419976
+ATTTGG 52.106293 1.153513 0.933735 0.355575
+ATTTGT 51.005476 0.955036 0.820222 0.292747
+ATTTTA 47.387338 0.882935 0.95042 0.365148
+ATTTTC 43.680568 0.671254 0.87479 0.322441
+ATTTTG 46.835383 0.85099 0.74252 0.252149
+ATTTTT 44.648344 0.707999 0.658351 0.210514
+CAAAAA 63.349074 0.914821 0.764854 0.263611
+CAAAAC 58.274062 0.955031 0.840366 0.303598
+CAAAAG 63.559373 0.766639 0.786706 0.274988
+CAAAAT 61.904635 0.889569 0.955632 0.368155
+CAAACA 57.00921 1.007173 0.863467 0.316201
+CAAACC 54.826654 1.045881 1.028622 0.41113
+CAAACG 56.831572 0.925331 0.855191 0.311666
+CAAACT 56.186659 0.783455 0.770019 0.266286
+CAAAGA 62.973485 1.013998 0.831957 0.299052
+CAAAGC 58.807107 0.832678 0.903814 0.338621
+CAAAGG 62.474692 0.766507 0.761636 0.261949
+CAAAGT 61.040381 1.119569 1.027838 0.41066
+CAAATA 56.629843 0.980875 0.887808 0.329666
+CAAATC 52.740477 1.412731 1.130287 0.473564
+CAAATG 55.916567 1.325794 0.984344 0.384871
+CAAATT 53.867451 1.610092 1.128122 0.472203
+CAACAA 64.402509 1.336054 0.919602 0.347532
+CAACAC 61.942423 0.917717 0.748008 0.25495
+CAACAG 64.690967 1.495032 1.052338 0.42543
+CAACAT 64.216003 1.335434 0.99164 0.389158
+CAACCA 60.134141 1.377425 0.941521 0.360031
+CAACCC 58.185058 1.16887 0.885795 0.328545
+CAACCG 60.141742 1.663558 0.924207 0.350146
+CAACCT 59.406561 1.148466 0.839656 0.303213
+CAACGA 63.874939 1.49396 0.984775 0.385124
+CAACGC 60.975304 0.954139 0.837214 0.301891
+CAACGG 62.772869 1.275172 0.972724 0.378077
+CAACGT 61.862286 1.108788 1.186178 0.50912
+CAACTA 59.523414 1.062005 0.707602 0.234573
+CAACTC 56.675746 0.667037 0.700681 0.23114
+CAACTG 58.433232 0.826352 0.733493 0.247565
+CAACTT 56.714295 1.038685 0.921811 0.348785
+CAAGAA 68.497703 1.888384 1.125869 0.47079
+CAAGAC 61.415025 0.914997 0.817016 0.291033
+CAAGAG 67.916907 2.437401 1.166654 0.496602
+CAAGAT 66.057962 1.741274 1.157481 0.490757
+CAAGCA 62.598346 2.030792 1.06609 0.433797
+CAAGCC 58.614138 1.020262 0.860312 0.31447
+CAAGCG 62.475528 2.154037 1.13429 0.476082
+CAAGCT 62.469476 2.61176 1.029915 0.411905
+CAAGGA 65.153017 1.784245 0.975436 0.379659
+CAAGGC 59.324533 1.046393 1.08088 0.442855
+CAAGGG 63.101839 1.054812 0.795336 0.279525
+CAAGGT 62.226564 0.951348 1.004738 0.396894
+CAAGTA 55.370963 1.137553 1.103894 0.457074
+CAAGTC 49.267992 1.206486 1.405485 0.656651
+CAAGTG 54.599357 1.901496 1.161897 0.493568
+CAAGTT 50.666494 1.40938 1.31644 0.595247
+CAATAA 59.247384 1.316933 0.861887 0.315334
+CAATAC 55.351272 0.833894 0.865822 0.317496
+CAATAG 58.98476 1.485414 0.830874 0.298468
+CAATAT 57.556469 1.213207 0.862949 0.315917
+CAATCA 53.342381 1.285069 1.082941 0.444122
+CAATCC 51.22366 1.044163 1.07303 0.438039
+CAATCG 53.253397 1.28603 1.044062 0.420421
+CAATCT 52.315955 1.03434 0.896728 0.334646
+CAATGA 54.105545 0.935759 1.095893 0.452113
+CAATGC 50.215913 1.115237 1.401774 0.654052
+CAATGG 54.055049 0.900831 0.884086 0.327595
+CAATGT 52.721193 0.819087 0.933777 0.355599
+CAATTA 49.633643 1.016175 1.241549 0.545182
+CAATTC 45.548992 1.090677 1.480266 0.709749
+CAATTG 48.84273 0.798671 1.019365 0.405593
+CAATTT 46.202677 0.981392 1.187202 0.509779
+CACAAA 64.60954 1.33692 0.91282 0.343695
+CACAAC 60.604163 1.280123 0.91817 0.346721
+CACAAG 65.729428 0.748544 0.911833 0.343137
+CACAAT 64.354269 0.93066 1.158217 0.491225
+CACACA 64.795798 1.805895 0.776657 0.269736
+CACACC 61.451262 0.697996 0.760079 0.261146
+CACACG 63.658259 0.731224 0.763592 0.262959
+CACACT 63.136627 0.76894 0.773101 0.267886
+CACAGA 66.333815 1.307496 0.879036 0.324792
+CACAGC 62.416093 1.283067 0.9938 0.390431
+CACAGG 66.349957 1.263067 0.910043 0.342128
+CACAGT 65.412429 1.369526 1.355325 0.621814
+CACATA 62.677251 1.164832 0.77098 0.266784
+CACATC 58.996279 1.518888 1.042845 0.419687
+CACATG 61.731558 1.535047 0.97556 0.379731
+CACATT 60.044309 2.281879 1.231402 0.538512
+CACCAA 67.537095 0.982119 0.897915 0.335311
+CACCAC 64.881274 0.797864 0.756994 0.259558
+CACCAG 68.722138 1.006604 0.954416 0.367453
+CACCAT 67.605244 0.976858 1.0088 0.399303
+CACCCA 65.647769 1.142029 0.818972 0.292078
+CACCCC 63.860739 1.074942 0.671988 0.217089
+CACCCG 65.551098 1.019521 0.87517 0.322652
+CACCCT 65.299397 1.1034 0.843697 0.305404
+CACCGA 67.929501 0.880144 0.842069 0.304521
+CACCGC 64.991218 0.94443 0.73429 0.247969
+CACCGG 67.273961 1.031245 1.025124 0.409034
+CACCGT 66.021745 0.973118 1.479973 0.709538
+CACCTA 63.957274 0.874502 0.673074 0.217616
+CACCTC 60.982316 1.344977 0.69222 0.226966
+CACCTG 62.720954 1.092593 0.942432 0.360554
+CACCTT 60.687607 2.232752 1.188086 0.510349
+CACGAA 70.018844 1.369399 1.089237 0.448001
+CACGAC 63.894768 0.950133 0.790283 0.276866
+CACGAG 69.323911 1.112009 0.957636 0.369314
+CACGAT 67.456757 0.926542 1.070488 0.436484
+CACGCA 66.800311 2.11369 0.96462 0.373362
+CACGCC 63.04183 0.782409 0.695742 0.228701
+CACGCG 66.224574 2.039716 0.984037 0.384691
+CACGCT 65.387877 1.496867 0.937932 0.357975
+CACGGA 64.880482 1.788024 0.916169 0.345588
+CACGGC 58.9927 1.178218 1.117177 0.465348
+CACGGG 63.640084 1.261852 0.949504 0.36462
+CACGGT 62.847199 1.475662 1.238865 0.543415
+CACGTA 54.116768 1.772272 1.305313 0.587716
+CACGTC 47.790571 2.364426 1.728838 0.895832
+CACGTG 52.948343 1.491197 1.440947 0.681659
+CACGTT 49.794839 2.23989 1.599512 0.797217
+CACTAA 63.969606 1.324908 0.72055 0.241041
+CACTAC 59.784228 0.854584 0.654594 0.208715
+CACTAG 63.467434 0.92063 0.796242 0.280003
+CACTAT 61.893169 1.306549 0.807295 0.285853
+CACTCA 58.87869 1.08541 0.740042 0.250888
+CACTCC 56.758626 0.733689 0.843057 0.305057
+CACTCG 59.429427 1.766496 0.914588 0.344694
+CACTCT 57.808405 0.963441 0.7465 0.254179
+CACTGA 55.899425 1.335823 1.023451 0.408034
+CACTGC 51.382473 1.211479 1.378943 0.638138
+CACTGG 56.529131 0.822477 0.874395 0.322223
+CACTGT 54.858147 1.144497 1.08017 0.442418
+CACTTA 51.233975 1.293466 1.17322 0.5008
+CACTTC 46.11297 1.376617 1.506402 0.728629
+CACTTG 50.687393 1.301756 1.160588 0.492734
+CACTTT 47.205764 1.454098 1.364106 0.627867
+CAGAAA 69.353787 1.198227 1.103638 0.456915
+CAGAAC 63.607133 1.576768 1.012131 0.401283
+CAGAAG 69.695226 1.134369 1.120808 0.467619
+CAGAAT 67.60965 1.721116 1.354631 0.621337
+CAGACA 61.317977 1.475662 0.789572 0.276492
+CAGACC 57.267754 0.712765 0.812076 0.288397
+CAGACG 60.221397 0.986955 0.834839 0.300607
+CAGACT 59.431674 0.788508 0.787105 0.275198
+CAGAGA 67.753117 1.245502 1.035493 0.415256
+CAGAGC 61.77997 1.032827 0.976366 0.380202
+CAGAGG 66.992133 1.566802 1.068737 0.435413
+CAGAGT 65.183459 1.802616 1.204676 0.521075
+CAGATA 58.587379 1.006026 0.887876 0.329703
+CAGATC 54.097191 1.34539 1.230763 0.538093
+CAGATG 57.98404 1.30578 1.012937 0.401762
+CAGATT 55.665326 1.78294 1.310149 0.590985
+CAGCAA 68.453862 1.02366 1.029772 0.41182
+CAGCAC 65.730992 1.04479 0.956953 0.368919
+CAGCAG 69.006631 0.990333 1.002875 0.395791
+CAGCAT 67.833129 1.115927 1.189751 0.511422
+CAGCCA 63.693257 1.079744 0.798643 0.281271
+CAGCCC 61.548145 0.780312 0.738381 0.250044
+CAGCCG 63.376435 1.065606 0.833287 0.299769
+CAGCCT 63.052979 0.922504 0.832673 0.299438
+CAGCGA 68.084662 1.099645 0.922669 0.349272
+CAGCGC 64.451025 0.9456 0.904032 0.338744
+CAGCGG 66.934209 0.950217 0.984688 0.385073
+CAGCGT 65.339195 1.133871 1.416516 0.664397
+CAGCTA 62.77253 0.770853 0.849103 0.308344
+CAGCTC 59.592935 1.473611 0.862084 0.315442
+CAGCTG 61.766979 1.048815 1.01091 0.400557
+CAGCTT 60.019731 2.488223 1.229024 0.536952
+CAGGAA 72.837378 2.61176 1.458146 0.6939
+CAGGAC 64.851964 1.482206 0.977802 0.381041
+CAGGAG 72.050789 2.447042 1.46758 0.700645
+CAGGAT 69.281846 1.896565 1.427369 0.672047
+CAGGCA 65.856843 2.61176 1.352563 0.619914
+CAGGCC 61.45372 1.645579 1.043223 0.419915
+CAGGCG 65.40549 2.61176 1.369015 0.631259
+CAGGCT 65.022253 2.54545 1.265512 0.561041
+CAGGGA 66.749482 1.623521 1.109525 0.460576
+CAGGGC 60.544167 0.930635 1.069178 0.435683
+CAGGGG 65.727974 1.228089 0.990527 0.388503
+CAGGGT 65.382068 1.362977 1.161753 0.493476
+CAGGTA 57.945179 0.97306 1.001705 0.395098
+CAGGTC 51.984514 1.225615 1.314839 0.594161
+CAGGTG 57.158159 1.086764 1.019418 0.405624
+CAGGTT 53.724342 1.546095 1.290921 0.578023
+CAGTAA 57.536056 1.57481 1.009903 0.399958
+CAGTAC 53.231992 1.191466 1.020605 0.406333
+CAGTAG 56.846551 1.613626 1.070317 0.436379
+CAGTAT 55.571147 1.89927 0.937732 0.35786
+CAGTCA 51.059641 2.146448 1.308305 0.589738
+CAGTCC 48.141019 1.510359 1.291674 0.578529
+CAGTCG 50.143111 1.862536 1.34868 0.617246
+CAGTCT 49.251668 1.67945 1.107859 0.459539
+CAGTGA 52.759255 0.961397 1.084461 0.445058
+CAGTGC 49.08598 0.904917 1.280458 0.571009
+CAGTGG 52.527141 1.059187 1.11021 0.461002
+CAGTGT 51.331703 0.936707 0.917334 0.346247
+CAGTTA 47.678719 0.841398 1.114051 0.463396
+CAGTTC 44.09144 0.918078 1.269395 0.563626
+CAGTTG 47.082199 0.820828 0.965184 0.373689
+CAGTTT 44.917437 0.731998 1.04674 0.42204
+CATAAA 64.321679 0.906081 0.744166 0.252988
+CATAAC 59.93314 0.992807 0.68034 0.221148
+CATAAG 65.039456 0.909801 0.811222 0.287942
+CATAAT 63.609638 0.759298 0.950182 0.365011
+CATACA 61.103716 1.46901 0.853581 0.310786
+CATACC 58.652074 0.96372 0.735755 0.248711
+CATACG 60.872672 1.289512 0.848282 0.307897
+CATACT 60.252133 1.245892 0.769284 0.265904
+CATAGA 64.25791 0.844236 0.771251 0.266925
+CATAGC 60.514512 1.282275 0.760411 0.261317
+CATAGG 63.832431 0.725822 0.754162 0.258103
+CATAGT 62.992738 0.695636 1.138359 0.478645
+CATATA 59.195073 0.795517 0.678791 0.220394
+CATATC 55.365075 1.082649 0.869886 0.319734
+CATATG 58.615491 0.869874 0.771975 0.267301
+CATATT 56.326885 1.401662 0.948946 0.364299
+CATCAA 63.476487 1.266465 0.982887 0.384017
+CATCAC 61.271772 0.90805 0.753217 0.257618
+CATCAG 64.291353 1.689591 1.132812 0.475152
+CATCAT 63.657377 1.231466 1.090247 0.448624
+CATCCA 60.474649 1.873167 1.043466 0.420061
+CATCCC 58.438444 1.314519 0.946586 0.362941
+CATCCG 60.27743 1.793647 1.050531 0.424335
+CATCCT 59.539721 1.812186 0.97416 0.378914
+CATCGA 63.306163 1.402253 1.099193 0.454157
+CATCGC 60.771039 0.912754 0.821213 0.293278
+CATCGG 62.465764 1.382857 1.101138 0.455363
+CATCGT 61.61781 1.375585 1.29438 0.580347
+CATCTA 59.046997 1.054052 0.799315 0.281626
+CATCTC 56.591172 0.611215 0.68655 0.224184
+CATCTG 58.174664 0.817402 0.834051 0.300181
+CATCTT 56.723264 0.813019 0.985195 0.38537
+CATGAA 63.397767 2.61176 1.407078 0.657768
+CATGAC 56.712494 1.624002 0.902652 0.337968
+CATGAG 61.853765 2.61176 1.16373 0.494736
+CATGAT 61.060786 2.14225 1.322356 0.599264
+CATGCA 58.569901 2.61176 1.429785 0.673754
+CATGCC 55.635879 2.465198 1.295932 0.581391
+CATGCG 57.727661 2.509963 1.458822 0.694383
+CATGCT 57.196113 1.986819 1.336416 0.608847
+CATGGA 59.837865 1.623641 1.105168 0.457865
+CATGGC 55.678491 0.801246 1.010375 0.400239
+CATGGG 58.766729 1.21127 0.942235 0.360441
+CATGGT 58.611559 1.136848 0.959193 0.370216
+CATGTA 51.700429 0.835284 0.937537 0.357748
+CATGTC 46.46914 1.047507 1.092241 0.449856
+CATGTG 50.996613 0.883666 0.896442 0.334486
+CATGTT 48.102683 1.461568 0.999163 0.393595
+CATTAA 56.891996 2.191185 1.134475 0.476198
+CATTAC 53.198387 1.233619 0.963395 0.372651
+CATTAG 56.196381 1.739992 1.117925 0.465816
+CATTAT 55.168349 1.976608 1.065414 0.433384
+CATTCA 50.449384 2.216367 1.404912 0.656249
+CATTCC 48.579992 1.626601 1.251118 0.551497
+CATTCG 50.775793 2.552085 1.313028 0.592934
+CATTCT 49.459176 1.772776 1.180307 0.505345
+CATTGA 51.946734 1.175914 1.184936 0.50832
+CATTGC 48.536562 0.897866 1.187219 0.509791
+CATTGG 52.035041 1.268348 0.953208 0.366755
+CATTGT 50.966755 1.151595 0.902621 0.337951
+CATTTA 47.212298 1.083699 1.17005 0.498772
+CATTTC 43.550235 0.892894 1.118512 0.466183
+CATTTG 46.57489 0.946141 0.904346 0.33892
+CATTTT 44.483305 0.710579 0.80276 0.283448
+CCAAAA 63.659316 1.010031 0.847152 0.307282
+CCAAAC 59.167549 1.674194 0.957742 0.369375
+CCAAAG 63.674094 0.805053 0.842112 0.304544
+CCAAAT 61.908259 0.920332 1.117455 0.465522
+CCAACA 58.482352 0.725364 0.88992 0.330843
+CCAACC 56.021786 0.799843 0.9087 0.34137
+CCAACG 58.144155 0.758936 0.903577 0.338488
+CCAACT 57.729476 0.868809 0.867588 0.318468
+CCAAGA 64.455695 0.821308 0.867328 0.318325
+CCAAGC 59.617298 1.097923 0.986098 0.385901
+CCAAGG 63.306361 0.800195 0.861041 0.31487
+CCAAGT 62.537176 1.08079 1.30535 0.587741
+CCAATA 58.091066 1.348429 0.923775 0.349901
+CCAATC 54.468122 1.942072 1.170868 0.499295
+CCAATG 57.330042 1.326828 1.053132 0.425912
+CCAATT 55.694326 1.737564 1.187531 0.509991
+CCACAA 67.286997 0.909159 0.891617 0.33179
+CCACAC 64.199111 0.986537 0.76113 0.261688
+CCACAG 68.046249 0.903832 0.886677 0.329036
+CCACAT 66.861154 0.930553 1.004346 0.396662
+CCACCA 63.589075 1.054008 0.762784 0.262541
+CCACCC 62.499424 1.817932 0.769561 0.266048
+CCACCG 63.417782 1.106563 0.785364 0.274285
+CCACCT 63.121106 1.126871 0.814239 0.28955
+CCACGA 66.896664 1.03856 0.802944 0.283546
+CCACGC 64.265825 1.288426 0.75814 0.260148
+CCACGG 65.883917 0.89782 0.882746 0.32685
+CCACGT 64.773577 0.730146 1.264421 0.560316
+CCACTA 62.247035 1.372825 0.726693 0.24413
+CCACTC 58.895719 1.078391 0.78952 0.276465
+CCACTG 60.964151 0.971046 0.855055 0.311592
+CCACTT 59.111075 1.513668 1.102662 0.456309
+CCAGAA 68.137185 1.908226 1.057232 0.428401
+CCAGAC 60.419537 0.87801 0.908821 0.341439
+CCAGAG 66.193028 1.170433 0.902937 0.338128
+CCAGAT 64.242686 1.088708 1.063617 0.432288
+CCAGCA 62.068063 1.443609 0.999433 0.393755
+CCAGCC 58.901609 0.878928 0.912552 0.343543
+CCAGCG 61.604249 1.271999 0.967589 0.375087
+CCAGCT 61.527144 1.573087 0.9755 0.379696
+CCAGGA 64.092947 1.032235 0.992758 0.389817
+CCAGGC 58.616047 1.242236 1.215456 0.528085
+CCAGGG 63.138704 1.130132 0.882309 0.326608
+CCAGGT 61.886128 1.039953 1.069221 0.435709
+CCAGTA 54.410978 1.428148 1.20853 0.523578
+CCAGTC 48.837168 1.98196 1.58287 0.784808
+CCAGTG 53.763007 1.803084 1.365891 0.629099
+CCAGTT 50.463854 2.149788 1.553224 0.762863
+CCATAA 61.314671 0.889176 0.770036 0.266294
+CCATAC 57.36437 0.942168 0.877783 0.324098
+CCATAG 61.170434 1.172174 0.798412 0.281149
+CCATAT 59.422835 0.710767 0.818576 0.291866
+CCATCA 55.879685 0.948597 0.98926 0.387758
+CCATCC 53.75617 0.955316 1.090897 0.449026
+CCATCG 55.723591 0.953076 0.940352 0.359361
+CCATCT 54.819428 0.72932 0.839606 0.303186
+CCATGA 55.515397 1.133663 1.156836 0.490346
+CCATGC 50.79965 1.143978 1.482311 0.711221
+CCATGG 55.561916 0.87697 1.04492 0.420939
+CCATGT 53.64029 0.931518 1.166633 0.496589
+CCATTA 50.486594 1.092219 1.298531 0.583141
+CCATTC 45.92663 1.292086 1.63907 0.826973
+CCATTG 49.854914 0.97003 1.308781 0.590059
+CCATTT 46.870347 1.490903 1.564569 0.771236
+CCCAAA 65.270611 1.032183 0.905064 0.339323
+CCCAAC 60.413654 1.360232 1.069737 0.436024
+CCCAAG 65.637081 0.814328 0.993098 0.390017
+CCCAAT 63.981467 1.180384 1.313786 0.593447
+CCCACA 64.505486 0.858783 0.779278 0.271103
+CCCACC 61.606713 0.557629 0.757942 0.260045
+CCCACG 63.810849 0.765329 0.786906 0.275093
+CCCACT 63.413454 0.793656 0.877485 0.323933
+CCCAGA 66.947537 1.445788 0.886604 0.328995
+CCCAGC 62.582094 1.466624 1.027647 0.410546
+CCCAGG 66.95901 1.096003 0.928371 0.352515
+CCCAGT 66.058776 1.953424 1.511735 0.732502
+CCCATA 62.962725 1.724972 0.957459 0.369212
+CCCATC 59.453574 1.757538 1.093382 0.450561
+CCCATG 62.732005 1.983273 1.166834 0.496717
+CCCATT 60.33345 2.075124 1.439587 0.680694
+CCCCAA 68.819956 1.060392 0.966816 0.374637
+CCCCAC 66.170728 1.308235 0.759714 0.260958
+CCCCAG 70.039044 0.798211 0.925706 0.350998
+CCCCAT 68.957242 0.835484 0.985395 0.385488
+CCCCCA 67.23186 0.973673 0.727189 0.24438
+CCCCCC 65.166503 0.659404 0.6164 0.190717
+CCCCCG 67.450766 0.81709 0.758981 0.26058
+CCCCCT 66.478322 0.700326 0.750498 0.256224
+CCCCGA 69.486444 0.904072 0.838422 0.302544
+CCCCGC 66.360841 1.207815 0.731556 0.246585
+CCCCGG 69.053267 0.811177 0.949615 0.364684
+CCCCGT 67.513885 0.890885 1.466744 0.700046
+CCCCTA 65.419536 1.43587 0.72688 0.244225
+CCCCTC 62.470566 2.18852 0.818198 0.291664
+CCCCTG 63.938178 1.33474 0.998509 0.393209
+CCCCTT 61.643003 1.853553 1.19054 0.511931
+CCCGAA 70.400953 1.069571 0.89783 0.335264
+CCCGAC 63.772372 1.135023 0.836337 0.301417
+CCCGAG 69.940438 0.875668 0.858063 0.313238
+CCCGAT 67.342047 1.092152 1.170418 0.499007
+CCCGCA 66.845421 1.448665 0.881705 0.326273
+CCCGCC 63.643869 0.741434 0.656601 0.209675
+CCCGCG 66.225785 1.260196 0.817179 0.291119
+CCCGCT 65.660613 1.058383 0.842351 0.304673
+CCCGGA 64.668347 1.280381 0.939226 0.358715
+CCCGGC 58.784501 1.572175 1.302406 0.585754
+CCCGGG 63.953703 1.387011 1.007704 0.398653
+CCCGGT 62.32336 1.716532 1.373201 0.634157
+CCCGTA 54.288856 2.61176 1.514511 0.734521
+CCCGTC 47.743511 2.380477 1.860323 0.999949
+CCCGTG 52.357318 1.958142 1.559834 0.767737
+CCCGTT 49.685045 2.598298 1.768217 0.926614
+CCCTAA 64.919579 0.814432 0.725978 0.24377
+CCCTAC 60.630861 0.83686 0.733113 0.247373
+CCCTAG 64.300875 1.250688 0.774528 0.268628
+CCCTAT 62.75763 0.846819 0.800901 0.282464
+CCCTCA 60.437876 0.821779 0.758823 0.260499
+CCCTCC 58.155521 0.722214 0.759931 0.26107
+CCCTCG 60.277235 0.77368 0.711201 0.236365
+CCCTCT 59.365975 0.677911 0.791162 0.277328
+CCCTGA 56.41268 1.470428 1.144373 0.482444
+CCCTGC 51.458807 1.172704 1.539571 0.752827
+CCCTGG 56.869998 0.934011 0.964399 0.373233
+CCCTGT 55.017758 1.032353 1.211527 0.525527
+CCCTTA 51.331396 0.960913 1.295934 0.581393
+CCCTTC 45.971193 1.257333 1.723252 0.891494
+CCCTTG 50.719159 1.319682 1.382519 0.640622
+CCCTTT 47.456014 1.510919 1.602132 0.799177
+CCGAAA 68.87529 1.59648 1.012775 0.401666
+CCGAAC 62.637144 1.241837 1.097174 0.452907
+CCGAAG 69.199229 1.41571 1.071362 0.437018
+CCGAAT 66.667798 1.79082 1.411389 0.660793
+CCGACA 61.392908 0.810442 0.730241 0.245921
+CCGACC 58.142047 0.696735 0.850983 0.309369
+CCGACG 60.956138 0.883273 0.770347 0.266456
+CCGACT 60.00047 0.730933 0.832295 0.299234
+CCGAGA 66.937264 1.121832 0.91145 0.342922
+CCGAGC 61.135296 1.463651 1.117809 0.465743
+CCGAGG 66.492798 1.294064 0.937203 0.357557
+CCGAGT 64.42076 1.375039 1.230516 0.537931
+CCGATA 58.631356 1.331424 1.059133 0.429557
+CCGATC 54.043455 1.712591 1.384525 0.642017
+CCGATG 57.933898 1.496154 1.188493 0.510611
+CCGATT 55.654999 2.14838 1.413046 0.661957
+CCGCAA 69.605687 1.150053 1.081191 0.443046
+CCGCAC 66.636919 1.427055 0.945927 0.362561
+CCGCAG 70.358004 0.899586 0.988378 0.38724
+CCGCAT 69.029348 1.240873 1.289017 0.576744
+CCGCCA 65.935655 0.800339 0.659641 0.211133
+CCGCCC 63.593814 0.765416 0.66333 0.212907
+CCGCCG 65.777202 0.764203 0.722456 0.241999
+CCGCCT 64.938924 0.689999 0.806469 0.285415
+CCGCGA 69.575031 1.018171 0.913243 0.343934
+CCGCGC 65.356057 1.760015 0.873053 0.321482
+CCGCGG 68.48116 1.011719 1.076248 0.440011
+CCGCGT 66.684851 1.057523 1.554343 0.763687
+CCGCTA 63.786862 1.3403 0.783999 0.27357
+CCGCTC 59.844428 1.445697 1.001719 0.395106
+CCGCTG 62.45187 1.546952 0.977773 0.381024
+CCGCTT 60.554699 2.071545 1.270586 0.564419
+CCGGAA 68.040256 2.296649 1.191617 0.512626
+CCGGAC 59.386829 1.091517 0.948372 0.363968
+CCGGAG 66.913267 2.61176 1.204506 0.520965
+CCGGAT 64.175291 1.539536 1.139353 0.479273
+CCGGCA 61.918896 2.434701 1.330025 0.604484
+CCGGCC 57.498238 1.298606 1.116897 0.465174
+CCGGCG 61.301204 2.344081 1.277925 0.569316
+CCGGCT 61.197115 2.61176 1.254353 0.553637
+CCGGGA 61.007425 1.375511 1.18022 0.505289
+CCGGGC 54.477711 1.412461 1.521236 0.739418
+CCGGGG 60.448099 1.097074 1.132959 0.475244
+CCGGGT 59.609995 0.981585 1.070045 0.436213
+CCGGTA 52.572085 1.097725 1.341071 0.612031
+CCGGTC 46.749043 1.211775 1.768694 0.926989
+CCGGTG 51.728496 0.902022 1.366408 0.629457
+CCGGTT 48.421841 1.512393 1.683913 0.861142
+CCGTAA 54.519318 1.367009 1.159659 0.492142
+CCGTAC 50.207812 0.972644 1.212731 0.526311
+CCGTAG 53.78879 1.429972 1.147457 0.484395
+CCGTAT 52.360162 1.174139 1.218074 0.529792
+CCGTCA 47.073558 1.724275 1.43647 0.678484
+CCGTCC 45.085788 1.345517 1.421865 0.668164
+CCGTCG 46.741757 1.572923 1.454086 0.691004
+CCGTCT 46.314821 1.720029 1.394472 0.648948
+CCGTGA 49.387708 1.037343 1.323622 0.600125
+CCGTGC 45.907291 0.99462 1.469377 0.701932
+CCGTGG 49.119364 1.199962 1.223123 0.53309
+CCGTGT 48.214427 0.965763 1.086675 0.446421
+CCGTTA 44.812246 0.94214 1.281301 0.571573
+CCGTTC 41.347767 0.916252 1.275768 0.567875
+CCGTTG 44.221068 0.786571 1.148129 0.484821
+CCGTTT 42.225216 0.693491 1.09498 0.451549
+CCTAAA 66.033342 0.939824 0.820634 0.292968
+CCTAAC 61.062798 1.051985 0.732182 0.246902
+CCTAAG 66.695736 0.854245 0.775121 0.268936
+CCTAAT 65.328213 0.995379 1.039647 0.417757
+CCTACA 62.701162 0.848449 0.796776 0.280285
+CCTACC 60.644675 0.929493 0.646207 0.204717
+CCTACG 63.173652 1.36439 0.801682 0.282877
+CCTACT 62.294535 0.891307 0.671156 0.216686
+CCTAGA 66.056588 0.99427 0.817353 0.291212
+CCTAGC 62.406732 2.517916 0.875286 0.322716
+CCTAGG 65.198719 1.454997 0.815576 0.290263
+CCTAGT 64.628762 0.867468 1.204351 0.520865
+CCTATA 60.595175 0.832985 0.720389 0.240961
+CCTATC 56.827843 1.115695 0.913199 0.343909
+CCTATG 59.975848 0.991528 0.83692 0.301732
+CCTATT 57.558531 1.97232 1.171807 0.499896
+CCTCAA 65.696732 0.960802 0.878113 0.324281
+CCTCAC 63.136074 0.715499 0.737982 0.249841
+CCTCAG 66.817223 1.241164 1.06901 0.43558
+CCTCAT 65.814283 0.983137 0.891004 0.331448
+CCTCCA 63.197024 1.336178 0.876225 0.323235
+CCTCCC 60.715608 0.850518 0.765771 0.264085
+CCTCCG 62.840807 1.3918 0.882765 0.326861
+CCTCCT 62.430879 1.12569 0.865316 0.317218
+CCTCGA 65.9032 1.036955 0.87408 0.322049
+CCTCGC 62.904972 0.725042 0.715309 0.238416
+CCTCGG 65.318159 1.093958 0.950322 0.365091
+CCTCGT 63.88262 1.02671 1.278221 0.569514
+CCTCTA 61.308671 0.603595 0.633638 0.198773
+CCTCTC 58.369196 0.996904 0.667045 0.214698
+CCTCTG 60.360059 0.801723 0.851848 0.309841
+CCTCTT 58.640572 1.241671 1.066286 0.433916
+CCTGAA 62.505627 2.272474 1.206313 0.522138
+CCTGAC 54.955481 1.124646 0.937223 0.357569
+CCTGAG 60.647442 2.021593 1.126453 0.471156
+CCTGAT 59.449399 2.242577 1.116565 0.464966
+CCTGCA 57.306908 2.521811 1.533456 0.748346
+CCTGCC 54.560539 2.131116 1.233712 0.540028
+CCTGCG 56.531583 2.087431 1.375709 0.635895
+CCTGCT 56.159934 1.952738 1.276205 0.568167
+CCTGGA 59.70857 1.41805 1.063903 0.432462
+CCTGGC 55.114676 0.764391 0.958909 0.370051
+CCTGGG 58.470183 1.090929 0.86144 0.315088
+CCTGGT 58.160678 1.035358 0.985519 0.385561
+CCTGTA 51.649645 0.969036 0.947611 0.36353
+CCTGTC 46.346245 1.242682 1.182675 0.506866
+CCTGTG 50.658858 1.119879 0.975009 0.37941
+CCTGTT 47.979256 1.51851 1.130915 0.473959
+CCTTAA 56.229784 1.63477 1.059468 0.429761
+CCTTAC 53.30031 1.496289 1.004357 0.396669
+CCTTAG 56.489155 1.525456 1.086762 0.446475
+CCTTAT 55.181726 1.334465 0.999828 0.393988
+CCTTCA 50.278084 2.001754 1.317701 0.596102
+CCTTCC 48.117517 2.068461 1.350975 0.618823
+CCTTCG 49.65237 1.845312 1.277579 0.569085
+CCTTCT 49.165088 1.705245 1.209162 0.523989
+CCTTGA 51.950197 1.291617 1.128235 0.472274
+CCTTGC 48.473865 0.865299 1.168809 0.497979
+CCTTGG 52.020067 1.675443 0.991835 0.389273
+CCTTGT 50.868046 1.150502 0.835139 0.300769
+CCTTTA 46.818131 0.893167 1.045322 0.421182
+CCTTTC 43.386344 0.906904 1.121203 0.467866
+CCTTTG 46.126986 0.845519 0.871844 0.320814
+CCTTTT 44.359797 0.680985 0.846847 0.307116
+CGAAAA 64.396877 1.087955 0.880393 0.325545
+CGAAAC 59.770465 1.248549 1.227019 0.535639
+CGAAAG 64.513394 0.910188 0.912195 0.343342
+CGAAAT 63.054721 1.201969 1.276321 0.568245
+CGAACA 57.083953 0.985342 1.043354 0.419994
+CGAACC 54.444168 0.888386 1.196433 0.515737
+CGAACG 56.813532 1.001007 1.074035 0.438655
+CGAACT 56.092601 0.851062 0.991716 0.389203
+CGAAGA 63.9289 0.990907 0.94392 0.361408
+CGAAGC 59.660436 1.242295 1.232166 0.539013
+CGAAGG 63.320527 1.290096 0.986803 0.386315
+CGAAGT 61.898221 1.307444 1.333739 0.607018
+CGAATA 57.205598 1.315273 1.21374 0.526967
+CGAATC 53.664635 1.975838 1.506327 0.728575
+CGAATG 56.272721 1.389489 1.358925 0.624293
+CGAATT 55.008306 2.154968 1.65062 0.83573
+CGACAA 63.880664 1.013214 0.743849 0.252826
+CGACAC 61.767626 1.169519 0.700365 0.230984
+CGACAG 64.257618 1.059888 0.777219 0.270029
+CGACAT 63.748298 0.924815 0.788293 0.27582
+CGACCA 59.238608 1.198006 0.887178 0.329315
+CGACCC 57.242439 0.793725 0.824506 0.295043
+CGACCG 58.90573 1.049798 0.843078 0.305068
+CGACCT 60.198372 2.61176 0.88667 0.329032
+CGACGA 63.010175 1.006609 0.764719 0.263541
+CGACGC 60.335898 0.876241 0.750304 0.256125
+CGACGG 62.148921 1.203406 0.812564 0.288656
+CGACGT 61.083902 1.078126 1.044946 0.420955
+CGACTA 58.881756 0.780481 0.679461 0.22072
+CGACTC 56.395325 0.751912 0.769624 0.266081
+CGACTG 57.884719 0.673466 0.755122 0.258596
+CGACTT 56.685502 1.188412 1.043595 0.420139
+CGAGAA 68.776307 2.043972 1.108618 0.460011
+CGAGAC 62.066618 1.014976 0.930993 0.354009
+CGAGAG 67.083926 1.868378 0.976247 0.380132
+CGAGAT 65.253887 1.207711 1.013997 0.402393
+CGAGCA 61.610126 1.99107 1.103259 0.456679
+CGAGCC 58.444518 0.986501 0.975422 0.37965
+CGAGCG 60.653323 1.296968 1.033485 0.414049
+CGAGCT 60.411703 2.141188 0.971643 0.377446
+CGAGGA 64.977161 1.066567 0.958246 0.369667
+CGAGGC 60.335076 1.071756 1.141733 0.480775
+CGAGGG 63.612261 1.043087 0.845372 0.306314
+CGAGGT 63.073796 0.937646 1.084874 0.445312
+CGAGTA 56.428687 1.054674 1.151877 0.487197
+CGAGTC 51.463273 1.570353 1.536469 0.750552
+CGAGTG 55.815626 1.369015 1.161156 0.493096
+CGAGTT 53.272791 1.677087 1.574791 0.778806
+CGATAA 58.055466 1.034393 0.827268 0.296527
+CGATAC 54.796714 0.832549 0.953883 0.367145
+CGATAG 57.779127 0.954171 0.814588 0.289736
+CGATAT 56.479877 0.920078 0.836125 0.301302
+CGATCA 51.993488 1.076776 1.134748 0.47637
+CGATCC 50.023139 1.025009 1.217397 0.529351
+CGATCG 51.870965 1.032095 1.117865 0.465779
+CGATCT 51.252348 0.927085 1.014972 0.402973
+CGATGA 54.363465 0.92976 1.098549 0.453758
+CGATGC 50.601709 1.130628 1.447678 0.686441
+CGATGG 53.944234 0.895371 1.008522 0.399139
+CGATGT 52.620484 0.849153 1.050568 0.424357
+CGATTA 49.504244 1.029929 1.321946 0.598985
+CGATTC 45.623761 1.035554 1.399682 0.652589
+CGATTG 48.767973 0.841294 1.110901 0.461433
+CGATTT 46.53011 1.250828 1.323325 0.599922
+CGCAAA 64.698985 1.159414 0.950295 0.365076
+CGCAAC 60.633671 1.634792 1.168855 0.498008
+CGCAAG 65.458297 0.905575 0.947997 0.363752
+CGCAAT 63.875667 1.037208 1.232956 0.539531
+CGCACA 62.696128 0.74542 0.816524 0.290769
+CGCACC 60.336468 0.766152 0.866965 0.318125
+CGCACG 62.52735 0.841142 0.840324 0.303574
+CGCACT 61.877106 0.710447 0.88444 0.327792
+CGCAGA 66.256396 1.043309 0.952474 0.366332
+CGCAGC 62.56658 2.066084 1.106536 0.458716
+CGCAGG 65.762335 1.089961 0.965614 0.373939
+CGCAGT 64.773615 1.398922 1.464348 0.698332
+CGCATA 62.2929 1.540323 0.925952 0.351138
+CGCATC 58.66193 1.997309 1.254236 0.553559
+CGCATG 61.240942 1.466395 1.105268 0.457928
+CGCATT 59.869643 2.17489 1.464591 0.698506
+CGCCAA 66.894701 0.82787 0.762072 0.262174
+CGCCAC 64.178004 0.928575 0.704986 0.233274
+CGCCAG 67.74025 0.817262 0.775287 0.269023
+CGCCAT 66.898282 0.753242 0.850065 0.308868
+CGCCCA 64.49597 0.988458 0.712606 0.237066
+CGCCCC 62.468685 0.753802 0.666847 0.214603
+CGCCCG 64.447142 0.976711 0.767892 0.265183
+CGCCCT 63.875403 0.836308 0.770788 0.266684
+CGCCGA 67.138153 0.842685 0.744879 0.253352
+CGCCGC 64.192694 0.878261 0.69849 0.230057
+CGCCGG 66.31143 0.931496 0.781149 0.27208
+CGCCGT 65.366566 0.925044 1.253728 0.553223
+CGCCTA 63.122728 0.82043 0.670728 0.216478
+CGCCTC 60.151736 1.104895 0.838815 0.302757
+CGCCTG 62.080027 1.07582 0.93042 0.353683
+CGCCTT 60.486604 1.473006 1.288365 0.576307
+CGCGAA 68.874522 1.282979 0.919759 0.347622
+CGCGAC 63.147005 0.954476 0.942391 0.360531
+CGCGAG 68.131344 0.814607 0.889533 0.330627
+CGCGAT 66.420303 1.135566 1.193355 0.513747
+CGCGCA 64.347204 1.075202 0.87932 0.32495
+CGCGCC 61.812049 0.795382 0.723622 0.242584
+CGCGCG 63.922121 0.983079 0.85309 0.310518
+CGCGCT 63.760879 0.974638 0.877645 0.324021
+CGCGGA 64.211896 1.083872 0.962089 0.371893
+CGCGGC 59.053093 1.439527 1.291661 0.57852
+CGCGGG 63.239423 1.362316 1.093457 0.450607
+CGCGGT 62.031224 1.590431 1.34773 0.616594
+CGCGTA 54.375589 2.002823 1.409641 0.659566
+CGCGTC 48.654659 2.267558 1.903154 1.03468
+CGCGTG 53.59235 2.21326 1.563764 0.770641
+CGCGTT 51.007605 2.410572 1.680204 0.858298
+CGCTAA 62.522489 0.893745 0.72318 0.242362
+CGCTAC 58.841414 0.763243 0.830315 0.298167
+CGCTAG 62.877119 1.222073 0.788893 0.276135
+CGCTAT 60.754641 0.675757 0.791647 0.277583
+CGCTCA 57.610832 0.808795 0.829701 0.297836
+CGCTCC 55.511223 0.866136 0.950006 0.364909
+CGCTCG 57.6062 0.854457 0.879797 0.325214
+CGCTCT 56.617495 0.830764 0.846269 0.306802
+CGCTGA 55.854895 1.25527 1.13562 0.476919
+CGCTGC 51.226379 1.184557 1.453378 0.6905
+CGCTGG 56.103465 0.930099 0.984214 0.384795
+CGCTGT 54.312881 1.018663 1.197299 0.516297
+CGCTTA 51.29458 1.233863 1.260704 0.557847
+CGCTTC 46.16782 1.210733 1.53855 0.752078
+CGCTTG 50.456879 1.012934 1.296936 0.582067
+CGCTTT 47.426357 1.387637 1.562931 0.770026
+CGGAAA 72.109398 1.510127 1.464159 0.698196
+CGGAAC 65.974428 2.058362 1.258596 0.556449
+CGGAAG 71.867759 1.266817 1.442547 0.682795
+CGGAAT 70.327373 1.366113 1.682147 0.859788
+CGGACA 60.98635 1.01762 0.796656 0.280222
+CGGACC 57.820712 0.891753 0.884814 0.327999
+CGGACG 60.47923 1.092959 0.843668 0.305388
+CGGACT 60.161985 1.191687 0.949943 0.364873
+CGGAGA 69.909384 1.684272 1.243645 0.546563
+CGGAGC 63.988253 1.752757 1.15311 0.487979
+CGGAGG 69.149277 1.17515 1.268292 0.562891
+CGGAGT 67.20017 1.571409 1.560243 0.76804
+CGGATA 60.380022 1.589693 1.042593 0.419534
+CGGATC 56.525453 1.422872 1.26824 0.562856
+CGGATG 59.881141 1.50624 1.176268 0.502753
+CGGATT 57.675673 1.911049 1.442167 0.682525
+CGGCAA 70.084245 1.141222 1.242386 0.545733
+CGGCAC 67.362771 1.197049 1.16656 0.496542
+CGGCAG 70.453514 1.149483 1.195671 0.515244
+CGGCAT 69.47186 1.222759 1.387997 0.644434
+CGGCCA 64.625233 1.025129 0.88997 0.330871
+CGGCCC 62.572584 0.917735 0.811461 0.288069
+CGGCCG 64.090063 1.024999 0.830453 0.298242
+CGGCCT 63.946747 0.869721 0.88115 0.325964
+CGGCGA 69.763433 1.082496 1.068467 0.435248
+CGGCGC 66.125557 0.975219 1.065778 0.433606
+CGGCGG 68.302646 1.130121 1.221656 0.532131
+CGGCGT 66.659409 1.248549 1.603925 0.800518
+CGGCTA 64.540381 1.125863 1.014311 0.40258
+CGGCTC 61.684025 1.401262 1.132928 0.475225
+CGGCTG 63.447588 1.054868 1.275729 0.567849
+CGGCTT 62.461937 1.413831 1.56992 0.775196
+CGGGAA 71.692093 2.596688 1.582918 0.784843
+CGGGAC 64.341233 1.692377 1.066814 0.434238
+CGGGAG 70.312481 2.61176 1.625322 0.816591
+CGGGAT 68.109481 1.845921 1.562271 0.769537
+CGGGCA 63.18932 2.61176 1.473856 0.705144
+CGGGCC 59.800418 1.966339 1.243538 0.546492
+CGGGCG 62.760021 2.468709 1.501761 0.725264
+CGGGCT 62.47069 2.61176 1.431389 0.674888
+CGGGGA 67.004016 1.869248 1.313096 0.59298
+CGGGGC 62.698146 2.02723 1.056162 0.427751
+CGGGGG 65.626813 1.68699 1.221906 0.532294
+CGGGGT 65.428397 1.330583 1.231793 0.538768
+CGGGTA 59.134747 1.805973 1.016649 0.403973
+CGGGTC 53.530028 1.360663 1.173363 0.500892
+CGGGTG 58.15849 1.138386 1.098556 0.453763
+CGGGTT 55.398218 1.245061 1.197587 0.516483
+CGGTAA 57.053113 1.724769 1.115762 0.464465
+CGGTAC 54.101765 1.868075 1.034752 0.41481
+CGGTAG 56.535149 1.602323 1.078813 0.441585
+CGGTAT 55.338624 1.617627 1.027729 0.410594
+CGGTCA 49.568226 1.861787 1.389841 0.645718
+CGGTCC 47.305844 1.54959 1.266373 0.561614
+CGGTCG 49.114118 1.941813 1.286719 0.575203
+CGGTCT 48.673932 1.987182 1.196538 0.515804
+CGGTGA 53.435875 1.252757 1.138628 0.478815
+CGGTGC 49.614849 0.746054 1.118952 0.466458
+CGGTGG 53.07491 1.526573 1.013707 0.40222
+CGGTGT 51.697332 0.932255 0.978732 0.381585
+CGGTTA 47.380493 0.980999 1.16279 0.494137
+CGGTTC 43.981493 0.830689 1.157866 0.491001
+CGGTTG 46.69661 0.872519 1.051797 0.425102
+CGGTTT 44.80761 0.764967 0.917298 0.346227
+CGTAAA 62.843539 1.056864 0.966773 0.374613
+CGTAAC 59.055099 0.87516 0.83568 0.301062
+CGTAAG 63.41045 1.079508 1.013424 0.402052
+CGTAAT 62.024042 0.96629 1.030701 0.412377
+CGTACA 58.955028 1.521864 1.181119 0.505866
+CGTACC 56.5976 1.132624 0.93559 0.356635
+CGTACG 59.030258 1.975099 1.211772 0.525686
+CGTACT 58.20025 1.918318 0.993114 0.390026
+CGTAGA 62.605304 1.10676 1.053712 0.426263
+CGTAGC 59.182985 0.703995 0.815191 0.290058
+CGTAGG 62.120652 1.011561 0.997864 0.392828
+CGTAGT 61.213675 1.091235 1.103258 0.456679
+CGTATA 58.135624 0.772834 0.76986 0.266203
+CGTATC 55.263159 0.94605 0.872708 0.321291
+CGTATG 57.51187 0.737208 0.894083 0.333167
+CGTATT 55.974469 0.954948 1.093119 0.450398
+CGTCAA 60.822011 1.524431 1.358214 0.623803
+CGTCAC 58.804809 1.248967 1.163591 0.494647
+CGTCAG 60.944078 2.264328 1.648031 0.833765
+CGTCAT 60.658885 1.6271 1.426071 0.67113
+CGTCCA 56.888332 2.55285 1.414516 0.66299
+CGTCCC 55.393567 1.912602 1.403395 0.655187
+CGTCCG 56.674745 2.323363 1.492288 0.718413
+CGTCCT 56.205212 1.911892 1.389662 0.645593
+CGTCGA 60.180536 2.065909 1.615785 0.809414
+CGTCGC 58.066135 1.486865 1.225208 0.534453
+CGTCGG 59.293284 1.93553 1.50181 0.7253
+CGTCGT 58.817387 1.556069 1.555073 0.764225
+CGTCTA 56.342648 1.461319 1.243463 0.546443
+CGTCTC 54.385496 0.861494 0.94288 0.360811
+CGTCTG 55.586004 1.194776 1.106977 0.45899
+CGTCTT 54.483835 1.050214 1.072584 0.437766
+CGTGAA 60.513469 2.584619 1.557293 0.765862
+CGTGAC 54.623297 1.394885 0.97164 0.377445
+CGTGAG 58.383314 2.11142 1.268908 0.563301
+CGTGAT 57.925085 2.331735 1.313635 0.593345
+CGTGCA 55.503978 2.61176 1.607348 0.803083
+CGTGCC 52.658352 1.998978 1.268359 0.562936
+CGTGCG 55.154888 2.61176 1.436738 0.678675
+CGTGCT 54.017663 2.09518 1.296745 0.581939
+CGTGGA 57.960543 1.804574 1.458665 0.69427
+CGTGGC 54.306604 0.963811 1.149172 0.485482
+CGTGGG 57.187679 1.646668 1.214208 0.527272
+CGTGGT 56.828163 1.39273 1.166562 0.496543
+CGTGTA 51.494247 0.802339 0.880429 0.325564
+CGTGTC 47.052779 0.896633 0.95351 0.36693
+CGTGTG 50.517393 0.781278 0.914674 0.344742
+CGTGTT 48.814763 1.496659 0.961322 0.371449
+CGTTAA 54.347626 2.253176 1.322499 0.599361
+CGTTAC 51.443744 1.7 1.0993 0.454223
+CGTTAG 53.65065 1.990401 1.389235 0.645296
+CGTTAT 52.732687 1.954118 1.113406 0.462994
+CGTTCA 48.167979 2.197241 1.420702 0.667344
+CGTTCC 46.181103 1.534325 1.294985 0.580754
+CGTTCG 47.911447 2.389324 1.274652 0.56713
+CGTTCT 47.281561 1.937417 1.317334 0.595853
+CGTTGA 50.240581 1.418574 1.247773 0.549286
+CGTTGC 47.290373 0.864485 1.175656 0.502361
+CGTTGG 50.051487 1.502599 1.074848 0.439153
+CGTTGT 49.224725 1.29478 0.931544 0.354324
+CGTTTA 45.749449 1.043711 1.131756 0.474487
+CGTTTC 42.711077 0.908299 1.045804 0.421474
+CGTTTG 45.300284 1.094524 0.910512 0.342392
+CGTTTT 43.500976 0.701109 0.798369 0.281126
+CTAAAA 64.155705 0.946376 0.750055 0.255997
+CTAAAC 59.269028 1.202082 0.927931 0.352264
+CTAAAG 64.473223 0.77275 0.748074 0.254983
+CTAAAT 62.726566 0.879815 1.014763 0.402849
+CTAACA 58.644593 0.756393 0.826109 0.295904
+CTAACC 56.035401 0.811726 0.871932 0.320863
+CTAACG 58.248236 0.885453 0.750155 0.256048
+CTAACT 57.736471 0.732661 0.762833 0.262566
+CTAAGA 64.667602 0.917899 0.816209 0.290601
+CTAAGC 60.239685 1.101896 0.905696 0.339679
+CTAAGG 63.655109 0.814829 0.811031 0.28784
+CTAAGT 62.303717 1.674803 1.229314 0.537142
+CTAATA 58.185018 0.807815 0.876399 0.323332
+CTAATC 54.60361 2.184005 1.164851 0.495451
+CTAATG 57.48663 1.503864 0.959997 0.370681
+CTAATT 55.812292 1.832208 1.330368 0.604718
+CTACAA 66.641517 0.835306 0.797413 0.280621
+CTACAC 63.957982 0.966286 0.738898 0.250306
+CTACAG 67.278028 0.954573 0.860729 0.314699
+CTACAT 66.385547 0.807789 0.925785 0.351043
+CTACCA 62.615099 0.925193 0.752495 0.257247
+CTACCC 60.93112 1.049942 0.7078 0.234672
+CTACCG 62.296025 0.95134 0.695937 0.228797
+CTACCT 61.808036 0.910863 0.703512 0.232543
+CTACGA 65.946126 0.953267 0.839396 0.303072
+CTACGC 62.998733 0.906837 0.719791 0.240661
+CTACGG 65.241887 0.864648 0.82176 0.293571
+CTACGT 63.919265 0.791438 1.182523 0.506768
+CTACTA 61.787769 1.376768 0.67644 0.21925
+CTACTC 58.225164 0.791312 0.769428 0.265979
+CTACTG 60.60458 0.888547 0.803747 0.283971
+CTACTT 58.833954 1.523487 1.107243 0.459155
+CTAGAA 68.068344 1.205173 0.958101 0.369583
+CTAGAC 62.059093 1.544878 0.784637 0.273904
+CTAGAG 68.619097 1.632723 1.062773 0.431774
+CTAGAT 64.087018 1.550552 1.107418 0.459264
+CTAGCA 62.472501 1.470523 0.902746 0.338021
+CTAGCC 59.344662 1.094863 0.761279 0.261765
+CTAGCG 61.254554 0.849425 0.854695 0.311395
+CTAGCT 60.577155 0.629066 0.825509 0.295582
+CTAGGA 65.250714 1.032783 0.799187 0.281558
+CTAGGC 59.233637 0.957405 1.027603 0.410519
+CTAGGG 63.356231 1.263987 0.899365 0.336124
+CTAGGT 62.871359 1.051557 0.938924 0.358543
+CTAGTA 56.715884 1.546682 1.143228 0.48172
+CTAGTC 50.943157 2.358706 1.143816 0.482092
+CTAGTG 55.07365 1.106154 1.044164 0.420483
+CTAGTT 53.368934 1.146452 1.217667 0.529527
+CTATAA 60.447987 0.711024 0.686432 0.224126
+CTATAC 56.608495 0.742035 0.724103 0.242827
+CTATAG 60.643439 1.366175 0.756664 0.259388
+CTATAT 58.960644 0.959217 0.73097 0.246289
+CTATCA 54.654101 0.85149 0.890877 0.331377
+CTATCC 52.85733 0.834342 0.934285 0.355889
+CTATCG 54.786043 0.966894 0.914443 0.344612
+CTATCT 53.99926 0.762087 0.807343 0.285879
+CTATGA 55.584481 1.016675 1.053642 0.426221
+CTATGC 51.502775 1.144447 1.381722 0.640068
+CTATGG 55.483166 0.987043 0.800065 0.282022
+CTATGT 53.697449 0.657039 0.939118 0.358654
+CTATTA 50.512441 1.080156 1.149782 0.485868
+CTATTC 46.34523 1.313615 1.436958 0.678831
+CTATTG 50.006792 0.923187 1.132528 0.474973
+CTATTT 47.691039 1.7853 1.273288 0.56622
+CTCAAA 64.128494 1.351809 0.853901 0.310961
+CTCAAC 59.712985 1.058644 0.932695 0.354981
+CTCAAG 64.88767 0.945405 0.907301 0.340583
+CTCAAT 63.419588 0.885285 1.059674 0.429887
+CTCACA 63.142864 0.734431 0.730916 0.246262
+CTCACC 60.618313 0.777963 0.759305 0.260747
+CTCACG 62.856566 0.999629 0.785937 0.274585
+CTCACT 62.300134 0.794776 0.798561 0.281227
+CTCAGA 65.894743 1.212638 0.861301 0.315013
+CTCAGC 62.216572 1.529026 1.021689 0.40698
+CTCAGG 65.66034 1.004681 0.977749 0.38101
+CTCAGT 64.571318 1.667209 1.379852 0.638769
+CTCATA 62.792041 1.51253 0.83631 0.301402
+CTCATC 59.038687 1.521415 0.991798 0.389251
+CTCATG 61.636301 1.539437 0.980938 0.382875
+CTCATT 59.871105 2.211442 1.299744 0.583959
+CTCCAA 67.098948 0.975633 0.869818 0.319697
+CTCCAC 64.484329 0.955622 0.839021 0.302869
+CTCCAG 68.173115 0.975112 0.986953 0.386403
+CTCCAT 66.950224 0.97543 1.045851 0.421502
+CTCCCA 65.055528 1.161696 0.967513 0.375042
+CTCCCC 63.266136 0.855286 0.7425 0.252139
+CTCCCG 65.003748 1.137075 0.871244 0.320483
+CTCCCT 64.741586 0.995328 0.865298 0.317208
+CTCCGA 67.705198 0.85726 0.866275 0.317745
+CTCCGC 64.497132 0.934018 0.802647 0.283388
+CTCCGG 66.998679 0.913177 0.993437 0.390217
+CTCCGT 65.82536 0.833335 1.459209 0.694659
+CTCCTA 63.964353 0.929272 0.739612 0.250669
+CTCCTC 60.688619 1.440569 0.801689 0.282881
+CTCCTG 62.558747 1.249417 0.952138 0.366139
+CTCCTT 61.401345 1.40073 1.176597 0.502964
+CTCGAA 68.84988 1.243621 1.006775 0.398102
+CTCGAC 63.092552 0.754443 0.738509 0.250109
+CTCGAG 68.399092 0.953653 0.92791 0.352252
+CTCGAT 66.452268 1.000528 1.052027 0.425241
+CTCGCA 65.145059 1.349451 0.829668 0.297819
+CTCGCC 62.896769 1.214915 0.7074 0.234473
+CTCGCG 65.070346 1.473933 0.863716 0.316338
+CTCGCT 64.611171 1.196713 0.899302 0.336089
+CTCGGA 64.601707 1.211324 0.913429 0.344039
+CTCGGC 58.687983 1.130746 1.124105 0.469684
+CTCGGG 63.263428 1.530343 1.013882 0.402325
+CTCGGT 62.23084 1.780844 1.178463 0.504161
+CTCGTA 54.304877 2.61176 1.362904 0.627037
+CTCGTC 48.352812 2.61176 1.539899 0.753067
+CTCGTG 52.461686 2.033147 1.449297 0.687593
+CTCGTT 50.759835 2.068825 1.47382 0.705118
+CTCTAA 62.949517 0.873915 0.726232 0.243898
+CTCTAC 59.485884 0.728265 0.639825 0.201691
+CTCTAG 63.489704 0.74333 0.745483 0.25366
+CTCTAT 61.392629 0.684879 0.693033 0.227366
+CTCTCA 59.383038 1.410812 0.810869 0.287754
+CTCTCC 56.690791 0.692161 0.705163 0.233362
+CTCTCG 58.891702 1.041683 0.712523 0.237025
+CTCTCT 58.194882 0.966865 0.739376 0.250549
+CTCTGA 55.90008 1.076122 0.940819 0.359629
+CTCTGC 51.12392 1.232717 1.249087 0.550154
+CTCTGG 56.402137 0.799298 0.781349 0.272184
+CTCTGT 54.251449 0.912213 0.962971 0.372405
+CTCTTA 50.915679 0.919359 1.011365 0.400827
+CTCTTC 45.812155 1.072663 1.368451 0.630869
+CTCTTG 50.305855 1.009656 1.041195 0.418691
+CTCTTT 47.398526 1.537969 1.203433 0.520269
+CTGAAA 69.068369 1.114639 1.245489 0.547779
+CTGAAC 63.553884 1.451731 1.197853 0.516655
+CTGAAG 69.201595 1.268002 1.302096 0.585544
+CTGAAT 67.424807 1.238101 1.523573 0.741123
+CTGACA 60.449292 1.080964 0.886932 0.329178
+CTGACC 57.325646 0.998871 0.769379 0.265953
+CTGACG 59.861625 0.872962 0.817171 0.291115
+CTGACT 59.36316 0.872443 0.843014 0.305033
+CTGAGA 67.176994 1.084495 1.05702 0.428272
+CTGAGC 61.61699 1.735316 1.076135 0.439942
+CTGAGG 66.484645 1.443339 1.109993 0.460867
+CTGAGT 64.787496 1.426874 1.525267 0.742359
+CTGATA 59.030144 1.315527 1.004947 0.397018
+CTGATC 54.675184 1.524981 1.076064 0.439898
+CTGATG 58.28586 1.305521 1.12638 0.47111
+CTGATT 56.259172 1.863681 1.237278 0.542371
+CTGCAA 68.862631 1.198267 1.298148 0.582883
+CTGCAC 65.916554 0.958582 1.093798 0.450817
+CTGCAG 69.448328 1.245975 1.281346 0.571603
+CTGCAT 68.221156 1.167017 1.447593 0.686381
+CTGCCA 64.283729 1.318915 1.166959 0.496797
+CTGCCC 62.181911 0.904277 0.945088 0.362079
+CTGCCG 63.974023 1.495822 1.139061 0.479088
+CTGCCT 63.732427 1.139465 1.044124 0.420459
+CTGCGA 68.638563 1.106533 1.220314 0.531254
+CTGCGC 64.729673 1.006903 1.042052 0.419208
+CTGCGG 67.186425 1.182869 1.287074 0.575441
+CTGCGT 65.331451 1.359999 1.712279 0.882992
+CTGCTA 63.427524 0.90907 0.999674 0.393897
+CTGCTC 60.433922 1.024324 1.128801 0.47263
+CTGCTG 62.25117 1.133467 1.197874 0.516668
+CTGCTT 61.056127 1.385849 1.457379 0.693353
+CTGGAA 68.849078 2.564746 1.489274 0.716238
+CTGGAC 60.876516 1.62644 0.885144 0.328183
+CTGGAG 67.729888 2.61176 1.49609 0.72116
+CTGGAT 65.664359 1.709571 1.370075 0.631992
+CTGGCA 62.711057 2.389631 1.278874 0.56995
+CTGGCC 58.956915 1.613818 1.00322 0.395995
+CTGGCG 62.130005 2.311308 1.224156 0.533766
+CTGGCT 61.6228 2.199763 1.200085 0.518099
+CTGGGA 62.908148 1.485856 1.181213 0.505927
+CTGGGC 56.473615 1.015248 1.104678 0.457561
+CTGGGG 62.003521 1.440902 1.064511 0.432833
+CTGGGT 61.468665 1.384448 1.099737 0.454494
+CTGGTA 54.622372 0.955712 0.95788 0.369455
+CTGGTC 48.844936 0.997973 1.165874 0.496104
+CTGGTG 53.766137 0.88902 0.916755 0.34592
+CTGGTT 50.684424 1.134591 1.106844 0.458907
+CTGTAA 56.115289 1.661114 0.981767 0.383361
+CTGTAC 51.681119 1.302148 0.963988 0.372995
+CTGTAG 55.419951 1.520827 1.011259 0.400764
+CTGTAT 53.749152 1.468705 0.87665 0.32347
+CTGTCA 48.317176 1.653628 1.206458 0.522232
+CTGTCC 46.612507 1.915747 1.181895 0.506365
+CTGTCG 47.998654 1.716614 1.083925 0.444728
+CTGTCT 47.592331 1.476684 1.041736 0.419017
+CTGTGA 51.380978 1.023433 1.028942 0.411322
+CTGTGC 47.332914 0.833768 1.072763 0.437876
+CTGTGG 51.143737 1.78852 0.904535 0.339027
+CTGTGT 49.620261 1.034798 0.839496 0.303126
+CTGTTA 45.948123 0.785071 1.030664 0.412354
+CTGTTC 42.588055 0.881578 1.113484 0.463043
+CTGTTG 45.385388 0.734538 0.858695 0.313584
+CTGTTT 43.501295 0.677656 0.866878 0.318077
+CTTAAA 64.093568 1.15837 0.917416 0.346294
+CTTAAC 60.320414 0.721635 0.799025 0.281472
+CTTAAG 64.864622 1.018762 1.046 0.421592
+CTTAAT 63.397943 1.051767 1.131886 0.474569
+CTTACA 60.671681 1.442129 1.06823 0.435103
+CTTACC 58.725852 1.078181 0.85745 0.312902
+CTTACG 60.729826 1.247556 1.057453 0.428536
+CTTACT 60.337915 1.224782 0.887325 0.329397
+CTTAGA 63.518325 0.839484 1.034182 0.414468
+CTTAGC 60.356665 0.713925 0.86077 0.314721
+CTTAGG 63.93602 0.953152 0.964956 0.373557
+CTTAGT 62.76735 0.791496 1.115657 0.464399
+CTTATA 59.454637 0.752816 0.759667 0.260934
+CTTATC 56.311475 1.195579 0.93643 0.357115
+CTTATG 58.863831 0.93779 0.932595 0.354924
+CTTATT 57.390211 1.022177 1.133259 0.475433
+CTTCAA 63.087763 1.489335 1.273371 0.566276
+CTTCAC 60.635632 1.388411 1.069185 0.435687
+CTTCAG 63.777782 1.85264 1.507142 0.729166
+CTTCAT 63.243178 1.381603 1.411094 0.660586
+CTTCCA 59.713911 2.026109 1.513331 0.733662
+CTTCCC 58.088256 1.516815 1.32415 0.600483
+CTTCCG 59.672782 1.937389 1.508065 0.729836
+CTTCCT 59.155861 1.778577 1.386616 0.643472
+CTTCGA 62.889947 1.906893 1.376618 0.636525
+CTTCGC 60.397556 1.120374 1.127107 0.471567
+CTTCGG 62.264648 1.667222 1.410138 0.659915
+CTTCGT 61.072613 1.716952 1.692603 0.867817
+CTTCTA 58.683057 1.231092 1.088591 0.447602
+CTTCTC 56.264437 0.777199 0.792488 0.278025
+CTTCTG 57.872357 1.232144 1.09293 0.450281
+CTTCTT 56.414633 1.062882 1.151542 0.486984
+CTTGAA 61.245943 2.423138 1.495573 0.720787
+CTTGAC 55.732754 1.279214 0.91134 0.34286
+CTTGAG 59.797723 2.366136 1.325968 0.60172
+CTTGAT 59.77592 2.477019 1.319618 0.597404
+CTTGCA 57.156848 2.61176 1.473587 0.704951
+CTTGCC 54.536283 1.965842 1.134162 0.476001
+CTTGCG 56.499634 2.61176 1.280132 0.570791
+CTTGCT 56.197627 2.111486 1.149582 0.485741
+CTTGGA 59.996602 2.092004 1.308587 0.589928
+CTTGGC 55.186864 0.829257 0.97202 0.377666
+CTTGGG 57.801591 1.32557 1.193069 0.513563
+CTTGGT 57.97425 1.300744 0.985055 0.385288
+CTTGTA 52.084304 0.986182 0.840144 0.303477
+CTTGTC 46.905845 0.933575 0.953007 0.36664
+CTTGTG 51.057392 0.804509 0.813315 0.289057
+CTTGTT 48.666968 1.661725 0.888357 0.329971
+CTTTAA 56.048327 2.157702 1.240838 0.544713
+CTTTAC 52.701675 1.486174 1.014104 0.402457
+CTTTAG 55.564449 2.069699 1.249672 0.55054
+CTTTAT 54.576495 1.741868 1.119189 0.466606
+CTTTCA 50.218784 2.261477 1.263455 0.559674
+CTTTCC 48.237017 2.064487 1.253642 0.553166
+CTTTCG 49.827662 2.122181 1.190155 0.511682
+CTTTCT 49.185407 1.941774 1.012425 0.401457
+CTTTGA 51.540177 1.106741 1.082955 0.444131
+CTTTGC 48.192325 0.806489 1.020201 0.406092
+CTTTGG 51.509972 1.296041 0.929556 0.35319
+CTTTGT 50.337154 1.004731 0.798917 0.281416
+CTTTTA 47.003509 1.053393 0.996078 0.391774
+CTTTTC 43.362571 0.607744 0.821025 0.293177
+CTTTTG 46.384833 0.880101 0.708802 0.23517
+CTTTTT 44.364824 0.761471 0.680359 0.221158
+GAAAAA 63.03844 0.875092 0.767271 0.264861
+GAAAAC 58.887184 1.29128 1.002477 0.395555
+GAAAAG 63.259133 0.887192 0.78546 0.274335
+GAAAAT 61.892365 0.869965 0.997188 0.392429
+GAAACA 56.767122 1.072825 1.061313 0.430884
+GAAACC 54.545732 1.015781 1.206126 0.522016
+GAAACG 56.66847 1.078987 1.015857 0.4035
+GAAACT 55.937638 0.964253 0.894438 0.333365
+GAAAGA 62.814589 0.92116 0.838119 0.30238
+GAAAGC 59.170679 1.002137 1.033417 0.414008
+GAAAGG 62.10731 0.913985 0.811827 0.288264
+GAAAGT 61.194133 0.867682 1.163241 0.494424
+GAAATA 56.821612 0.899474 1.025092 0.409016
+GAAATC 53.750026 1.92076 1.267326 0.562248
+GAAATG 56.016857 1.161292 1.180946 0.505755
+GAAATT 54.518466 1.614127 1.25646 0.555032
+GAACAA 62.502689 1.434187 0.92842 0.352543
+GAACAC 60.414643 0.917161 0.802806 0.283473
+GAACAG 62.300897 1.543487 1.045818 0.421483
+GAACAT 62.461306 1.500217 1.059077 0.429523
+GAACCA 58.896179 2.428662 1.077558 0.440815
+GAACCC 56.897714 1.416549 1.151314 0.48684
+GAACCG 58.101875 1.801513 1.097744 0.45326
+GAACCT 57.547078 1.550509 0.959998 0.370682
+GAACGA 61.419602 1.564365 1.03913 0.417446
+GAACGC 59.53023 1.148356 0.93303 0.355172
+GAACGG 60.847549 1.492095 0.996875 0.392244
+GAACGT 60.181274 1.383101 1.156265 0.489983
+GAACTA 57.859914 1.007303 0.835697 0.301071
+GAACTC 55.854446 0.844105 0.816845 0.290941
+GAACTG 57.095748 0.977134 0.817476 0.291278
+GAACTT 55.600714 0.949872 0.899598 0.336255
+GAAGAA 67.93773 2.442705 1.148562 0.485095
+GAAGAC 61.508866 0.973314 0.853376 0.310675
+GAAGAG 67.381212 2.61176 1.14242 0.481209
+GAAGAT 65.089841 1.626304 1.11772 0.465688
+GAAGCA 62.2931 2.61081 1.182146 0.506527
+GAAGCC 58.413011 1.210893 1.016227 0.403721
+GAAGCG 61.117193 2.119292 1.143959 0.482182
+GAAGCT 61.109608 2.195522 1.062697 0.431727
+GAAGGA 63.983215 1.761982 1.063864 0.432438
+GAAGGC 59.426321 1.071823 1.138869 0.478967
+GAAGGG 62.670416 1.189681 0.915957 0.345468
+GAAGGT 62.033403 1.153436 1.041143 0.41866
+GAAGTA 55.2951 1.529257 1.201906 0.51928
+GAAGTC 49.833931 1.387324 1.493536 0.719314
+GAAGTG 54.526454 1.714487 1.22733 0.535843
+GAAGTT 51.593569 1.72449 1.434163 0.676851
+GAATAA 58.873176 1.737109 1.011306 0.400792
+GAATAC 54.943652 1.030326 0.91927 0.347344
+GAATAG 57.712749 1.363741 0.987586 0.386774
+GAATAT 57.089702 1.30243 0.955337 0.367985
+GAATCA 52.693648 1.330769 1.120007 0.467118
+GAATCC 50.870866 1.143831 1.246295 0.548311
+GAATCG 52.576081 1.402671 1.16638 0.496427
+GAATCT 51.90713 1.164769 0.989391 0.387835
+GAATGA 53.911551 0.82394 1.0822 0.443667
+GAATGC 50.370062 0.967839 1.4085 0.658765
+GAATGG 53.711632 0.952946 0.922487 0.349169
+GAATGT 52.800774 0.829731 0.885087 0.328151
+GAATTA 49.542036 0.87792 1.268228 0.562848
+GAATTC 45.678181 1.136203 1.566356 0.772558
+GAATTG 48.79741 0.747799 1.044604 0.420749
+GAATTT 46.347394 0.952979 1.323984 0.600371
+GACAAA 64.195221 1.201442 0.786036 0.274637
+GACAAC 60.087602 1.043062 0.800836 0.28243
+GACAAG 65.021936 0.718333 0.788647 0.276007
+GACAAT 63.957282 0.942989 0.934697 0.356124
+GACACA 63.413093 1.329799 0.774245 0.26848
+GACACC 60.652249 0.712061 0.699929 0.230768
+GACACG 62.953161 1.174522 0.781714 0.272375
+GACACT 61.3375 2.101202 0.817661 0.291377
+GACAGA 65.630216 0.971595 0.802225 0.283165
+GACAGC 61.500171 1.021013 0.868328 0.318875
+GACAGG 65.128777 1.172576 0.810371 0.287489
+GACAGT 64.519184 1.111327 1.194801 0.514681
+GACATA 62.107613 1.207419 0.713167 0.237346
+GACATC 58.303037 1.286289 0.943145 0.360963
+GACATG 61.330817 1.270959 0.86783 0.318601
+GACATT 59.504639 1.668577 1.144086 0.482262
+GACCAA 65.456212 1.294378 1.012377 0.401429
+GACCAC 63.129907 0.814602 0.747344 0.25461
+GACCAG 66.192836 1.397281 1.156076 0.489863
+GACCAT 65.445338 1.290743 1.108474 0.459921
+GACCCA 62.76752 1.632349 1.062005 0.431306
+GACCCC 61.547436 1.41343 0.90744 0.340661
+GACCCG 62.918083 1.585285 1.054832 0.426943
+GACCCT 62.292801 1.304606 0.83596 0.301213
+GACCGA 65.500514 1.525609 1.02141 0.406813
+GACCGC 62.930549 0.806449 0.745971 0.253909
+GACCGG 64.89253 1.27384 1.166768 0.496675
+GACCGT 63.941127 1.284075 1.438318 0.679795
+GACCTA 61.563883 1.072968 0.730498 0.24605
+GACCTC 59.300767 0.82004 0.691118 0.226425
+GACCTG 60.844364 0.916032 0.888534 0.33007
+GACCTT 59.143846 1.275294 1.084214 0.444906
+GACGAA 68.045522 1.807979 1.158652 0.491501
+GACGAC 63.190713 0.843365 0.715685 0.238604
+GACGAG 67.674079 1.366208 1.109884 0.460799
+GACGAT 66.036729 1.186733 1.076328 0.44006
+GACGCA 64.70098 2.347846 1.030341 0.412161
+GACGCC 62.280948 1.562055 0.734507 0.248079
+GACGCG 64.61461 2.233174 1.003687 0.396271
+GACGCT 63.971509 1.83911 1.016581 0.403932
+GACGGA 63.706542 0.91365 0.847798 0.307634
+GACGGC 58.560359 1.074094 0.943748 0.361309
+GACGGG 62.471061 1.135868 0.926588 0.3515
+GACGGT 61.552746 1.736238 1.206632 0.522345
+GACGTA 53.749058 1.798076 1.207511 0.522916
+GACGTC 47.76064 2.392751 1.596546 0.795
+GACGTG 52.600983 1.718474 1.256369 0.554972
+GACGTT 49.821777 2.315992 1.460767 0.695772
+GACTAA 62.684406 1.278343 0.786133 0.274688
+GACTAC 59.069813 1.254115 0.686651 0.224233
+GACTAG 62.704918 0.73132 0.869371 0.31945
+GACTAT 61.051946 0.898379 0.866729 0.317995
+GACTCA 58.612339 1.346064 0.913771 0.344232
+GACTCC 56.410666 1.435916 0.879029 0.324788
+GACTCG 58.301825 1.272703 0.891329 0.331629
+GACTCT 57.910819 1.37948 0.825241 0.295438
+GACTGA 55.625022 1.018379 0.840609 0.303729
+GACTGC 51.088607 1.046163 1.047256 0.422352
+GACTGG 56.247005 0.879739 0.716909 0.239217
+GACTGT 54.509083 0.820406 0.863102 0.316001
+GACTTA 51.331438 0.984787 0.992002 0.389372
+GACTTC 46.245222 1.128113 1.368909 0.631186
+GACTTG 50.340011 0.803475 0.799142 0.281534
+GACTTT 47.19998 1.250951 1.071199 0.436918
+GAGAAA 70.499425 1.274303 1.205053 0.52132
+GAGAAC 65.407634 1.188005 1.038055 0.416798
+GAGAAG 71.054873 1.192178 1.24689 0.548703
+GAGAAT 69.156764 2.278769 1.42327 0.669154
+GAGACA 61.45078 1.195754 0.790246 0.276847
+GAGACC 58.20406 0.695761 0.841636 0.304286
+GAGACG 60.640802 0.966122 0.796964 0.280384
+GAGACT 59.995623 0.852481 0.896765 0.334667
+GAGAGA 68.979504 1.785835 1.094332 0.451148
+GAGAGC 63.510875 1.437364 1.024013 0.40837
+GAGAGG 67.67155 1.820619 1.05986 0.43
+GAGAGT 66.373045 1.806281 1.410976 0.660503
+GAGATA 60.07428 1.331786 0.986348 0.386047
+GAGATC 56.063543 1.657443 1.250742 0.551248
+GAGATG 59.523754 1.330802 1.048704 0.423228
+GAGATT 57.543409 1.895212 1.407401 0.657994
+GAGCAA 68.437409 1.079081 1.052488 0.425521
+GAGCAC 65.826894 1.133984 0.936367 0.357079
+GAGCAG 68.859138 1.18912 1.015567 0.403328
+GAGCAT 67.773167 1.149621 1.167006 0.496827
+GAGCCA 63.05909 1.342069 0.868916 0.319199
+GAGCCC 61.149429 0.964898 0.72866 0.245122
+GAGCCG 62.75193 1.194612 0.877229 0.323791
+GAGCCT 62.276017 0.986482 0.780083 0.271523
+GAGCGA 67.779083 1.222869 0.929028 0.352889
+GAGCGC 64.394004 0.938647 0.900239 0.336614
+GAGCGG 66.633731 1.186501 0.981912 0.383446
+GAGCGT 65.129623 1.060222 1.355566 0.62198
+GAGCTA 62.886334 0.809587 0.838039 0.302337
+GAGCTC 59.539476 1.334159 0.843271 0.305173
+GAGCTG 61.72672 0.860439 0.982935 0.384045
+GAGCTT 60.958183 0.953197 1.187225 0.509794
+GAGGAA 73.54304 2.363824 1.343021 0.613366
+GAGGAC 65.725995 1.192785 0.951271 0.365638
+GAGGAG 72.316077 2.483992 1.450407 0.688383
+GAGGAT 70.098387 1.662427 1.453843 0.690831
+GAGGCA 65.63892 2.227595 1.256343 0.554955
+GAGGCC 62.49375 1.424875 0.972738 0.378085
+GAGGCG 66.107436 2.360823 1.160687 0.492797
+GAGGCT 65.159443 2.213457 1.167854 0.497368
+GAGGGA 67.567889 1.624013 1.053291 0.426008
+GAGGGC 61.644097 0.991927 1.012871 0.401723
+GAGGGG 65.960607 1.3591 0.97741 0.380812
+GAGGGT 65.896099 1.413593 1.125909 0.470815
+GAGGTA 59.091816 1.126048 0.995246 0.391283
+GAGGTC 53.794012 2.340019 1.310074 0.590934
+GAGGTG 58.031217 0.966091 1.106669 0.458798
+GAGGTT 55.218944 1.419541 1.320611 0.598078
+GAGTAA 59.064593 1.396389 0.947635 0.363544
+GAGTAC 55.116521 0.928676 0.963315 0.372604
+GAGTAG 59.025355 1.331813 0.976773 0.38044
+GAGTAT 57.696498 1.463756 0.919566 0.347512
+GAGTCA 52.191645 1.466367 1.23027 0.537769
+GAGTCC 49.987817 1.057741 1.048406 0.423048
+GAGTCG 51.964848 1.91851 1.245505 0.54779
+GAGTCT 51.039826 1.027321 0.959514 0.370401
+GAGTGA 54.728522 0.869596 1.09931 0.45423
+GAGTGC 51.347278 1.192493 1.30939 0.590472
+GAGTGG 54.360211 0.82377 0.943912 0.361404
+GAGTGT 53.316284 0.690812 0.955034 0.36781
+GAGTTA 49.546 0.902628 1.158223 0.491228
+GAGTTC 45.813592 1.029264 1.278606 0.569771
+GAGTTG 48.798089 0.868361 1.009748 0.399866
+GAGTTT 46.647325 0.955268 1.09792 0.453369
+GATAAA 63.450412 1.027393 0.811636 0.288163
+GATAAC 59.720891 0.734755 0.722649 0.242095
+GATAAG 64.0928 1.286407 0.929462 0.353137
+GATAAT 62.84698 0.995428 0.987236 0.386569
+GATACA 60.139432 1.687878 0.936155 0.356958
+GATACC 57.882815 1.102216 0.802319 0.283215
+GATACG 59.736969 1.419393 0.935226 0.356427
+GATACT 59.543204 1.495296 0.882509 0.326719
+GATAGA 63.192025 1.19666 0.928438 0.352553
+GATAGC 59.923074 0.867828 0.774896 0.268819
+GATAGG 63.038558 1.045994 0.877939 0.324184
+GATAGT 62.033226 0.944313 1.071123 0.436872
+GATATA 58.84052 0.717034 0.703003 0.23229
+GATATC 55.5534 1.237583 0.72384 0.242694
+GATATG 58.169538 0.860062 0.793343 0.278475
+GATATT 56.418917 1.613976 0.976554 0.380312
+GATCAA 61.719381 1.51542 1.14954 0.485715
+GATCAC 59.64418 1.297668 0.956616 0.368724
+GATCAG 62.010063 2.201562 1.219235 0.53055
+GATCAT 61.845659 1.858557 1.271838 0.565253
+GATCCA 58.251773 2.26077 1.151346 0.48686
+GATCCC 56.529601 1.623014 1.115656 0.464399
+GATCCG 58.123725 1.955543 1.123465 0.469283
+GATCCT 57.294639 2.091202 1.03877 0.417229
+GATCGA 61.203683 2.141486 1.250125 0.55084
+GATCGC 59.204621 1.362633 1.033852 0.414269
+GATCGG 60.387361 1.878648 1.218931 0.530352
+GATCGT 60.08274 1.73829 1.332727 0.606327
+GATCTA 57.136874 1.416827 0.913497 0.344077
+GATCTC 55.527217 0.840525 0.759944 0.261077
+GATCTG 56.802988 1.285729 0.938411 0.358249
+GATCTT 55.318332 1.004553 0.999081 0.393547
+GATGAA 63.451378 2.61176 1.389985 0.645818
+GATGAC 56.740413 1.475997 0.838907 0.302807
+GATGAG 61.013469 2.356034 1.141589 0.480684
+GATGAT 60.834649 2.220315 1.298043 0.582813
+GATGCA 57.940463 2.61176 1.529245 0.745265
+GATGCC 55.342055 2.280498 1.217804 0.529616
+GATGCG 57.717606 2.587786 1.418572 0.665844
+GATGCT 56.979329 2.502117 1.35086 0.618744
+GATGGA 59.638906 1.846063 1.156011 0.489822
+GATGGC 55.812866 0.860822 1.016984 0.404172
+GATGGG 58.409958 1.357002 0.871358 0.320546
+GATGGT 58.223579 1.347088 1.034064 0.414397
+GATGTA 52.1775 0.929748 0.857754 0.313069
+GATGTC 46.838797 1.22883 1.039104 0.41743
+GATGTG 51.226366 0.966682 0.840016 0.303408
+GATGTT 48.59354 1.361804 0.99433 0.390743
+GATTAA 56.559919 1.976655 1.114708 0.463807
+GATTAC 53.581516 1.777348 1.059636 0.429863
+GATTAG 56.234067 2.101476 1.19079 0.512092
+GATTAT 55.137055 1.790147 1.051874 0.425149
+GATTCA 51.213461 2.52025 1.311381 0.591818
+GATTCC 48.699447 1.755911 1.227344 0.535852
+GATTCG 50.695017 1.978451 1.218944 0.53036
+GATTCT 49.898956 1.988716 1.137681 0.478218
+GATTGA 52.156096 1.320004 1.140059 0.479718
+GATTGC 48.930982 0.905269 1.029423 0.41161
+GATTGG 51.992184 1.308006 0.88934 0.33052
+GATTGT 51.254534 1.213777 0.85727 0.312804
+GATTTA 47.954252 1.368358 1.162799 0.494142
+GATTTC 44.125445 0.808475 1.032523 0.413471
+GATTTG 46.983918 0.937369 0.859334 0.313934
+GATTTT 44.893757 0.701041 0.789264 0.27633
+GCAAAA 63.631943 0.985339 0.835118 0.300758
+GCAAAC 58.973597 1.361549 1.020208 0.406096
+GCAAAG 63.568885 0.816935 0.858744 0.31361
+GCAAAT 61.902332 0.941054 1.11222 0.462255
+GCAACA 58.397266 0.871078 0.963499 0.372711
+GCAACC 56.058237 0.811614 1.025495 0.409257
+GCAACG 58.115259 0.873142 0.965838 0.374069
+GCAACT 57.692662 0.984716 0.890295 0.331052
+GCAAGA 64.285613 0.874865 0.826927 0.296344
+GCAAGC 59.794744 1.064385 1.015632 0.403366
+GCAAGG 63.336075 0.835792 0.845833 0.306565
+GCAAGT 62.064067 1.314671 1.21792 0.529692
+GCAATA 58.264575 1.398784 0.987302 0.386607
+GCAATC 54.935072 1.735741 1.26726 0.562204
+GCAATG 57.580375 1.433237 1.074419 0.43889
+GCAATT 55.958778 2.109985 1.32902 0.603799
+GCACAA 66.415132 0.959978 0.825321 0.295481
+GCACAC 63.570021 0.994506 0.766497 0.264461
+GCACAG 66.93082 1.164755 0.962557 0.372164
+GCACAT 65.945087 0.999221 0.930557 0.353761
+GCACCA 62.788205 1.192085 0.837214 0.301891
+GCACCC 61.302691 1.306052 0.845332 0.306292
+GCACCG 62.357056 1.121735 0.858778 0.313629
+GCACCT 62.234185 1.22699 0.879413 0.325001
+GCACGA 65.79821 1.022728 0.841168 0.304032
+GCACGC 64.281157 1.655397 0.825601 0.295632
+GCACGG 64.884681 1.069689 0.886718 0.329059
+GCACGT 63.808188 1.120615 1.273976 0.566679
+GCACTA 61.599869 0.975894 0.706474 0.234013
+GCACTC 58.308346 1.019254 0.782447 0.272758
+GCACTG 60.393589 1.101589 0.874773 0.322432
+GCACTT 58.895015 1.36298 1.138278 0.478594
+GCAGAA 67.490688 2.135912 1.029258 0.411511
+GCAGAC 60.844749 1.114994 0.942951 0.360852
+GCAGAG 66.335962 1.918664 0.996975 0.392303
+GCAGAT 64.018117 0.954744 1.08028 0.442486
+GCAGCA 61.813279 1.452647 1.090131 0.448553
+GCAGCC 58.978991 0.90263 1.027405 0.4104
+GCAGCG 61.466364 1.288523 1.016177 0.403692
+GCAGCT 61.116632 1.359442 0.992342 0.389572
+GCAGGA 63.998115 1.060693 0.984523 0.384976
+GCAGGC 58.723835 1.259971 1.213583 0.526865
+GCAGGG 62.92602 0.87531 0.86026 0.314442
+GCAGGT 61.949374 1.060897 1.034194 0.414475
+GCAGTA 54.805048 1.522294 1.361315 0.625941
+GCAGTC 49.221705 2.061414 1.603672 0.800329
+GCAGTG 53.979284 1.784787 1.331321 0.605368
+GCAGTT 51.042353 2.13432 1.589755 0.789933
+GCATAA 61.068588 0.938676 0.771643 0.267129
+GCATAC 57.389289 0.903432 0.931109 0.354076
+GCATAG 60.7977 0.93147 0.85116 0.309465
+GCATAT 59.407293 0.899097 0.890414 0.331119
+GCATCA 55.785448 1.031467 1.024965 0.408939
+GCATCC 53.816499 1.119145 1.191955 0.512844
+GCATCG 55.663978 1.020706 0.998697 0.39332
+GCATCT 54.787455 0.84466 0.884908 0.328052
+GCATGA 55.64739 1.009371 1.151934 0.487233
+GCATGC 51.137095 1.145229 1.518116 0.737145
+GCATGG 55.538766 0.82042 1.049003 0.423409
+GCATGT 53.863131 0.93299 1.214957 0.52776
+GCATTA 50.832269 1.231484 1.444853 0.684433
+GCATTC 46.049054 1.293336 1.549309 0.759981
+GCATTG 49.973102 1.079151 1.330347 0.604703
+GCATTT 47.298247 1.604673 1.582084 0.784223
+GCCAAA 64.728822 1.205173 0.842614 0.304816
+GCCAAC 60.109988 1.145764 0.959952 0.370655
+GCCAAG 65.223601 0.863015 0.890126 0.330958
+GCCAAT 63.839691 1.130188 1.172033 0.50004
+GCCACA 64.41856 1.654014 0.794004 0.278824
+GCCACC 61.291539 0.696956 0.761982 0.262127
+GCCACG 63.435294 0.737131 0.753865 0.25795
+GCCACT 62.861179 0.776119 0.843725 0.30542
+GCCAGA 66.763757 1.452063 0.845489 0.306378
+GCCAGC 62.250216 1.344288 0.949791 0.364785
+GCCAGG 66.197322 1.101237 0.875521 0.322846
+GCCAGT 65.437537 1.603516 1.393232 0.648083
+GCCATA 62.64455 1.05119 0.799051 0.281486
+GCCATC 59.367255 1.5772 1.069697 0.436
+GCCATG 61.818871 1.737203 1.04611 0.421659
+GCCATT 60.086415 2.121303 1.300369 0.58438
+GCCCAA 67.716852 0.923991 0.970105 0.376551
+GCCCAC 65.168728 0.985137 0.758978 0.260579
+GCCCAG 68.830696 0.984293 0.95272 0.366474
+GCCCAT 67.905194 0.904255 1.024728 0.408797
+GCCCCA 66.26599 1.003579 0.800573 0.282291
+GCCCCC 64.310262 0.998221 0.641309 0.202393
+GCCCCG 66.055304 1.065609 0.815676 0.290316
+GCCCCT 65.515981 1.083419 0.830574 0.298306
+GCCCGA 68.384992 0.881067 0.88191 0.326386
+GCCCGC 65.319975 0.937818 0.74358 0.252689
+GCCCGG 67.739794 0.973328 0.950845 0.365393
+GCCCGT 66.606845 1.044161 1.446435 0.685557
+GCCCTA 64.359311 1.153685 0.687075 0.224441
+GCCCTC 60.936037 1.218355 0.706614 0.234082
+GCCCTG 62.926035 1.684004 0.957735 0.369371
+GCCCTT 61.598697 1.779852 1.271016 0.564706
+GCCGAA 69.368183 1.18954 0.90565 0.339653
+GCCGAC 63.487308 0.982048 0.755901 0.258996
+GCCGAG 68.96439 1.1367 0.865501 0.31732
+GCCGAT 66.8722 1.180902 1.099172 0.454144
+GCCGCA 66.333272 1.612317 0.912779 0.343672
+GCCGCC 63.01348 0.754182 0.655971 0.209374
+GCCGCG 66.035014 1.553519 0.870183 0.319898
+GCCGCT 65.230584 1.289525 0.880052 0.325356
+GCCGGA 64.36772 1.566173 0.896708 0.334635
+GCCGGC 58.767315 1.118341 1.222519 0.532695
+GCCGGG 63.685757 1.617924 0.964981 0.373571
+GCCGGT 61.939248 1.684886 1.226359 0.535207
+GCCGTA 53.782453 2.286641 1.417731 0.665252
+GCCGTC 47.744492 2.537251 1.772167 0.92972
+GCCGTG 52.676945 2.214303 1.448656 0.687137
+GCCGTT 49.313242 2.61176 1.732486 0.898669
+GCCTAA 64.32833 1.185924 0.74235 0.252063
+GCCTAC 60.234223 0.825181 0.75327 0.257645
+GCCTAG 63.937268 1.124593 0.737894 0.249797
+GCCTAT 62.14951 0.654902 0.749186 0.255552
+GCCTCA 59.826408 0.923224 0.775644 0.269209
+GCCTCC 57.770659 0.783221 0.862943 0.315914
+GCCTCG 59.822934 0.9543 0.805241 0.284763
+GCCTCT 59.185123 0.871129 0.782935 0.273013
+GCCTGA 56.258895 1.291966 1.016141 0.40367
+GCCTGC 51.300739 1.239291 1.379379 0.638441
+GCCTGG 56.751394 0.881879 0.891621 0.331792
+GCCTGT 54.901752 1.166447 1.142555 0.481295
+GCCTTA 51.397788 1.001258 1.192827 0.513407
+GCCTTC 46.267608 1.474691 1.451843 0.689406
+GCCTTG 50.466415 0.974684 1.135549 0.476875
+GCCTTT 47.327532 1.464534 1.439273 0.680471
+GCGAAA 69.037445 1.468786 1.0708 0.436675
+GCGAAC 63.054337 1.709127 1.113435 0.463012
+GCGAAG 69.371032 1.138193 1.068607 0.435334
+GCGAAT 67.15862 1.716792 1.307932 0.589486
+GCGACA 61.489795 0.839408 0.814545 0.289713
+GCGACC 58.402427 0.83973 0.938031 0.358032
+GCGACG 60.914443 0.826325 0.809456 0.287002
+GCGACT 60.200438 0.716876 0.906025 0.339864
+GCGAGA 67.291435 1.471358 0.943242 0.361019
+GCGAGC 61.773159 1.363107 1.10961 0.460629
+GCGAGG 66.434178 1.07598 0.939037 0.358608
+GCGAGT 64.764883 1.537533 1.336354 0.608804
+GCGATA 59.237589 1.334358 1.036394 0.415798
+GCGATC 54.733944 1.833365 1.413105 0.661999
+GCGATG 58.259676 1.588051 1.200268 0.518218
+GCGATT 56.164172 2.209443 1.448238 0.68684
+GCGCAA 69.174882 0.96357 1.025695 0.409376
+GCGCAC 66.328849 1.116005 0.94538 0.362247
+GCGCAG 69.808988 0.986297 1.057354 0.428476
+GCGCAT 68.636142 1.122079 1.219629 0.530807
+GCGCCA 65.368428 0.908451 0.756259 0.25918
+GCGCCC 63.117547 0.899473 0.699261 0.230438
+GCGCCG 65.042628 1.02576 0.783108 0.273104
+GCGCCT 64.662672 0.792458 0.771262 0.266931
+GCGCGA 69.128294 1.083391 0.940546 0.359472
+GCGCGC 65.556022 1.794392 0.969311 0.376088
+GCGCGG 67.765655 0.989864 1.048536 0.423127
+GCGCGT 66.189725 0.996334 1.486944 0.714557
+GCGCTA 63.837612 1.466603 0.850985 0.30937
+GCGCTC 60.020143 1.344374 0.914779 0.344802
+GCGCTG 62.328542 1.408984 0.979453 0.382006
+GCGCTT 60.589809 2.400917 1.278743 0.569863
+GCGGAA 68.005281 2.248594 1.226993 0.535622
+GCGGAC 59.770591 1.033605 0.962395 0.372071
+GCGGAG 67.147187 2.187193 1.226905 0.535564
+GCGGAT 64.541098 1.818435 1.156604 0.490199
+GCGGCA 62.18232 2.61176 1.36561 0.628905
+GCGGCC 57.975877 1.310626 1.116287 0.464793
+GCGGCG 61.714253 2.61176 1.272659 0.5658
+GCGGCT 61.184667 2.317462 1.209993 0.524529
+GCGGGA 61.259538 1.219916 1.197038 0.516128
+GCGGGC 55.170682 1.276632 1.514895 0.7348
+GCGGGG 60.753019 1.103593 1.096537 0.452512
+GCGGGT 60.030064 1.027036 1.114029 0.463383
+GCGGTA 53.17991 1.23784 1.37844 0.637789
+GCGGTC 47.383261 1.427477 1.662854 0.845038
+GCGGTG 52.331803 1.309788 1.348274 0.616968
+GCGGTT 49.210919 1.685847 1.658081 0.841403
+GCGTAA 55.101052 1.48502 1.235219 0.541017
+GCGTAC 50.967631 1.003466 1.184349 0.507943
+GCGTAG 54.399466 1.641103 1.203058 0.520026
+GCGTAT 52.931661 1.134139 1.04325 0.419931
+GCGTCA 47.860581 1.525446 1.56025 0.768045
+GCGTCC 45.657784 1.270494 1.536553 0.750614
+GCGTCG 47.732707 1.563537 1.461165 0.696056
+GCGTCT 46.893712 1.093751 1.342262 0.612846
+GCGTGA 50.353453 0.965903 1.29635 0.581673
+GCGTGC 46.702847 1.032407 1.516894 0.736255
+GCGTGG 49.851945 1.04732 1.197705 0.516559
+GCGTGT 48.963615 0.974899 1.094114 0.451013
+GCGTTA 45.675566 1.139752 1.369747 0.631766
+GCGTTC 42.155928 1.022941 1.383239 0.641123
+GCGTTG 45.016865 0.969215 1.166793 0.496691
+GCGTTT 43.034888 0.886573 1.167747 0.4973
+GCTAAA 65.498572 0.943605 0.735798 0.248733
+GCTAAC 61.026863 1.19342 0.74026 0.250999
+GCTAAG 66.316187 0.895823 0.841226 0.304064
+GCTAAT 64.566326 0.866614 1.024835 0.408861
+GCTACA 62.183088 1.196538 0.80967 0.287116
+GCTACC 60.002142 0.90214 0.704359 0.232963
+GCTACG 61.952921 1.124363 0.808904 0.286709
+GCTACT 61.693415 1.106998 0.810151 0.287372
+GCTAGA 64.730234 1.060223 0.7725 0.267573
+GCTAGC 62.444105 1.70846 0.881877 0.326368
+GCTAGG 64.749258 1.157172 0.909523 0.341834
+GCTAGT 63.692513 1.047835 1.147422 0.484373
+GCTATA 60.755085 1.344537 0.71532 0.238422
+GCTATC 56.528174 1.236436 0.903927 0.338684
+GCTATG 59.333185 1.382568 0.855184 0.311663
+GCTATT 57.767154 1.309477 1.014219 0.402525
+GCTCAA 64.89781 1.117394 0.933015 0.355163
+GCTCAC 62.389682 0.93171 0.721299 0.241417
+GCTCAG 65.822335 1.302505 1.103807 0.45702
+GCTCAT 64.911001 1.101443 1.089545 0.448191
+GCTCCA 61.901219 1.521841 0.969883 0.376422
+GCTCCC 59.89635 1.296015 0.880065 0.325362
+GCTCCG 61.65622 1.448107 0.97459 0.379165
+GCTCCT 61.127448 1.417127 0.97996 0.382303
+GCTCGA 64.854441 1.347603 1.016424 0.403838
+GCTCGC 62.143314 0.717241 0.72199 0.241764
+GCTCGG 64.119476 1.291629 1.008778 0.39929
+GCTCGT 62.984693 1.453484 1.185297 0.508553
+GCTCTA 60.421458 1.122133 0.749168 0.255543
+GCTCTC 57.783463 0.79008 0.711297 0.236413
+GCTCTG 59.500005 0.87146 0.818714 0.29194
+GCTCTT 58.038566 0.909735 1.008174 0.398932
+GCTGAA 62.40898 2.61176 1.296335 0.581663
+GCTGAC 55.164854 1.156927 0.922145 0.348975
+GCTGAG 60.960434 2.61176 1.163019 0.494283
+GCTGAT 59.895738 2.372288 1.239037 0.543528
+GCTGCA 57.539972 2.61176 1.375526 0.635768
+GCTGCC 54.282738 2.124996 1.289245 0.576897
+GCTGCG 56.806952 2.414082 1.426974 0.671768
+GCTGCT 55.938799 2.053739 1.232669 0.539343
+GCTGGA 59.38544 1.35922 1.109546 0.460589
+GCTGGC 55.122669 0.814357 0.974541 0.379136
+GCTGGG 58.400184 1.16689 0.936065 0.356906
+GCTGGT 57.969872 0.970396 0.96399 0.372996
+GCTGTA 51.571507 0.850963 0.929814 0.353337
+GCTGTC 46.461103 1.506872 1.172479 0.500326
+GCTGTG 50.495697 0.94745 0.940128 0.359232
+GCTGTT 48.096506 1.431804 1.132191 0.474761
+GCTTAA 56.604183 1.802302 1.099313 0.454232
+GCTTAC 53.371811 1.733359 0.942887 0.360815
+GCTTAG 56.813648 2.312422 1.337546 0.609619
+GCTTAT 55.058727 1.693715 0.959505 0.370396
+GCTTCA 50.477005 2.079335 1.402388 0.654482
+GCTTCC 48.244627 1.943329 1.365272 0.628672
+GCTTCG 50.270144 2.266496 1.335211 0.608024
+GCTTCT 49.206653 1.846006 1.144219 0.482346
+GCTTGA 52.007867 1.06733 1.230089 0.537651
+GCTTGC 48.511463 0.842672 1.078348 0.4413
+GCTTGG 51.937992 1.167075 0.904355 0.338925
+GCTTGT 50.828728 1.321964 0.905945 0.339819
+GCTTTA 47.186932 0.97757 1.143282 0.481754
+GCTTTC 43.538019 0.821287 1.102138 0.455983
+GCTTTG 46.454751 0.918785 0.904633 0.339081
+GCTTTT 44.487183 0.677995 0.845079 0.306155
+GGAAAA 65.776375 1.436127 1.121285 0.467917
+GGAAAC 61.780122 1.888523 1.488881 0.715955
+GGAAAG 65.853395 1.289505 1.195033 0.514832
+GGAAAT 64.619756 1.675809 1.520645 0.738988
+GGAACA 57.842741 1.208456 1.255486 0.554387
+GGAACC 55.355897 1.13081 1.372853 0.633915
+GGAACG 57.44372 1.043212 1.183323 0.507283
+GGAACT 57.040659 1.193309 1.18199 0.506426
+GGAAGA 65.374113 1.274995 1.100774 0.455138
+GGAAGC 62.050225 1.954057 1.341441 0.612284
+GGAAGG 64.563229 1.54941 1.173657 0.50108
+GGAAGT 63.617874 1.758631 1.674043 0.853582
+GGAATA 59.287103 2.490196 1.436775 0.678701
+GGAATC 55.536407 2.156223 1.783917 0.938982
+GGAATG 57.959434 1.646484 1.454237 0.691112
+GGAATT 56.903622 2.450876 1.780965 0.936652
+GGACAA 63.03225 0.988733 0.750366 0.256156
+GGACAC 61.787689 0.944702 0.715978 0.238751
+GGACAG 63.171252 1.231063 0.780398 0.271687
+GGACAT 63.065327 1.050277 0.816665 0.290845
+GGACCA 59.062296 2.01087 0.935886 0.356804
+GGACCC 56.059445 0.883963 0.850919 0.309334
+GGACCG 57.920588 1.262594 0.800162 0.282073
+GGACCT 57.157037 0.846114 0.749223 0.255571
+GGACGA 62.519891 1.613725 0.86839 0.318909
+GGACGC 59.781607 0.913018 0.812372 0.288554
+GGACGG 61.032079 1.001316 0.883681 0.32737
+GGACGT 60.312065 0.981859 0.989926 0.38815
+GGACTA 58.509705 0.853306 0.732448 0.247036
+GGACTC 56.324167 0.779401 0.845238 0.306241
+GGACTG 57.632651 0.847334 0.812268 0.288499
+GGACTT 56.284178 1.153699 1.138331 0.478628
+GGAGAA 68.490197 1.260708 0.982279 0.383661
+GGAGAC 63.445665 1.315366 1.102484 0.456199
+GGAGAG 67.872523 1.200636 1.038085 0.416816
+GGAGAT 66.227237 1.228277 1.190481 0.511892
+GGAGCA 61.563922 1.288709 1.067985 0.434954
+GGAGCC 58.905772 1.035457 1.022417 0.407416
+GGAGCG 61.164977 1.230546 1.022497 0.407463
+GGAGCT 60.824288 1.514769 0.996233 0.391865
+GGAGGA 65.549107 0.996732 0.93992 0.359113
+GGAGGC 61.407192 0.988115 1.268396 0.56296
+GGAGGG 64.309387 1.253921 0.996014 0.391736
+GGAGGT 63.69619 0.958224 1.219141 0.530489
+GGAGTA 57.882057 1.376458 1.356762 0.622803
+GGAGTC 52.915209 1.760507 1.647591 0.83343
+GGAGTG 57.264403 1.481715 1.437941 0.679527
+GGAGTT 54.78872 2.17369 1.636514 0.82504
+GGATAA 58.495532 1.115755 0.918117 0.346691
+GGATAC 55.406562 0.834057 0.97481 0.379294
+GGATAG 58.230718 1.077022 0.864086 0.316542
+GGATAT 57.066619 0.958662 0.913641 0.344158
+GGATCA 52.484706 1.189103 1.215092 0.527848
+GGATCC 50.853001 1.160914 1.436078 0.678207
+GGATCG 52.413663 1.260789 1.229963 0.537568
+GGATCT 51.667658 0.947547 1.048058 0.422837
+GGATGA 55.047188 1.021262 1.158383 0.49133
+GGATGC 51.1963 1.034323 1.320411 0.597942
+GGATGG 54.539721 1.007772 1.029448 0.411625
+GGATGT 53.176726 0.841874 1.109387 0.46049
+GGATTA 49.986414 0.924279 1.207861 0.523143
+GGATTC 46.519222 0.963747 1.486494 0.714234
+GGATTG 49.448829 0.96979 1.229183 0.537057
+GGATTT 47.473537 1.13338 1.411298 0.660729
+GGCAAA 65.335006 1.311918 1.00448 0.396741
+GGCAAC 61.471871 1.554539 1.226124 0.535053
+GGCAAG 65.734692 0.884285 1.010616 0.400382
+GGCAAT 64.841285 1.379267 1.345173 0.61484
+GGCACA 63.144918 0.988475 0.921336 0.348516
+GGCACC 60.893704 0.963062 0.904191 0.338833
+GGCACG 62.836555 0.913873 0.881289 0.326041
+GGCACT 62.443591 0.982364 0.944246 0.361596
+GGCAGA 66.619828 1.184066 0.97677 0.380438
+GGCAGC 63.488235 1.67015 1.128188 0.472245
+GGCAGG 66.11195 1.114541 1.038647 0.417155
+GGCAGT 65.66404 1.504743 1.507046 0.729096
+GGCATA 63.088647 1.407531 0.987621 0.386795
+GGCATC 59.933426 2.079687 1.29169 0.578539
+GGCATG 62.118529 1.775352 1.164148 0.495003
+GGCATT 60.74723 2.61176 1.507146 0.729169
+GGCCAA 66.138113 0.889855 0.780184 0.271576
+GGCCAC 64.232899 1.195911 0.719967 0.240749
+GGCCAG 66.680163 1.043995 0.800705 0.28236
+GGCCAT 66.223851 0.7842 0.919737 0.347609
+GGCCCA 63.72723 1.253416 0.769605 0.266071
+GGCCCC 61.656724 0.769121 0.731973 0.246796
+GGCCCG 63.870018 1.273985 0.853628 0.310812
+GGCCCT 62.9468 1.669028 0.818673 0.291918
+GGCCGA 66.105643 0.930982 0.797456 0.280644
+GGCCGC 63.935113 0.881625 0.771787 0.267203
+GGCCGG 65.111825 0.976297 0.836577 0.301546
+GGCCGT 64.63627 0.973238 1.2391 0.543569
+GGCCTA 62.700424 0.988784 0.717434 0.239479
+GGCCTC 60.476341 1.274789 0.858356 0.313398
+GGCCTG 61.759584 0.96015 0.901602 0.337379
+GGCCTT 60.380025 1.521324 1.28769 0.575854
+GGCGAA 68.675437 0.98239 0.940356 0.359363
+GGCGAC 63.997362 1.088576 1.013486 0.402089
+GGCGAG 68.364869 1.007423 0.964911 0.373531
+GGCGAT 66.806186 1.080602 1.264656 0.560472
+GGCGCA 64.231524 1.056469 0.908057 0.341008
+GGCGCC 61.759965 0.662626 0.730325 0.245963
+GGCGCG 63.916894 1.056861 0.871471 0.320608
+GGCGCT 63.787246 0.961336 0.910921 0.342623
+GGCGGA 64.639689 1.030762 0.954484 0.367493
+GGCGGC 59.939105 1.718671 1.226208 0.535108
+GGCGGG 63.724549 1.40037 1.033997 0.414357
+GGCGGT 62.88088 1.451832 1.429613 0.673633
+GGCGTA 55.509609 1.985161 1.37594 0.636055
+GGCGTC 50.337927 2.61176 1.844357 0.987104
+GGCGTG 54.797792 2.352612 1.536571 0.750627
+GGCGTT 52.211511 2.61176 1.747264 0.910192
+GGCTAA 62.624391 0.943432 0.831232 0.298661
+GGCTAC 59.391817 0.876438 0.90018 0.336581
+GGCTAG 63.166432 1.468851 0.852476 0.310183
+GGCTAT 61.02181 0.774239 0.85513 0.311633
+GGCTCA 58.199976 0.981085 0.994307 0.390729
+GGCTCC 56.057767 0.904228 0.959219 0.37023
+GGCTCG 57.842173 0.888159 0.924947 0.350567
+GGCTCT 56.952308 0.858562 0.831019 0.298546
+GGCTGA 56.514896 1.205107 1.130448 0.473665
+GGCTGC 51.917854 1.242424 1.425171 0.670495
+GGCTGG 56.595184 0.921912 0.993981 0.390537
+GGCTGT 54.988953 1.171243 1.251748 0.551913
+GGCTTA 52.016077 1.243934 1.393094 0.647986
+GGCTTC 47.022573 1.546404 1.590674 0.790619
+GGCTTG 51.535854 1.590911 1.30594 0.588139
+GGCTTT 48.700333 1.74322 1.574746 0.778773
+GGGAAA 74.365867 1.864154 1.533335 0.748257
+GGGAAC 68.79642 2.5364 1.503404 0.726455
+GGGAAG 74.03082 1.777916 1.508884 0.730431
+GGGAAT 73.08537 2.61176 1.837744 0.981799
+GGGACA 63.047958 0.929969 0.852594 0.310248
+GGGACC 59.734034 0.954313 1.019739 0.405816
+GGGACG 62.324779 1.175584 0.958814 0.369996
+GGGACT 61.761797 1.226301 1.037289 0.416337
+GGGAGA 72.164629 1.480893 1.398546 0.651794
+GGGAGC 66.954034 1.829276 1.30826 0.589707
+GGGAGG 71.293619 1.416432 1.364192 0.627926
+GGGAGT 69.517749 2.100618 1.703596 0.876285
+GGGATA 63.074423 1.428696 1.208611 0.523631
+GGGATC 59.282478 1.677024 1.455251 0.691835
+GGGATG 62.083254 2.013317 1.338411 0.61021
+GGGATT 60.460419 2.503903 1.724023 0.892092
+GGGCAA 71.102013 1.285974 1.356815 0.62284
+GGGCAC 68.595741 1.252906 1.188615 0.51069
+GGGCAG 71.133895 1.236309 1.197639 0.516516
+GGGCAT 70.461852 1.341868 1.415073 0.663382
+GGGCCA 65.199654 0.885466 0.864027 0.316509
+GGGCCC 63.36093 1.545591 0.86905 0.319273
+GGGCCG 64.995375 1.158692 0.911146 0.34275
+GGGCCT 64.430247 0.907487 0.984689 0.385074
+GGGCGA 70.410062 1.147805 1.148627 0.485136
+GGGCGC 67.254379 1.381424 1.163754 0.494751
+GGGCGG 68.974364 1.100307 1.244636 0.547216
+GGGCGT 67.515397 1.250142 1.692133 0.867455
+GGGCTA 65.700309 1.230647 1.03687 0.416085
+GGGCTC 63.482441 2.375516 1.248927 0.550048
+GGGCTG 64.613155 1.202135 1.255506 0.5544
+GGGCTT 63.865463 2.246298 1.61651 0.809959
+GGGGAA 74.40981 1.821873 1.387568 0.644135
+GGGGAC 66.731329 0.811555 1.056283 0.427824
+GGGGAG 73.559973 2.113222 1.390528 0.646197
+GGGGAT 71.000225 1.520771 1.400868 0.653418
+GGGGCA 66.661005 2.359576 1.167331 0.497035
+GGGGCC 62.729457 1.329746 0.999337 0.393698
+GGGGCG 65.427893 2.61176 1.170059 0.498778
+GGGGCT 65.148317 2.254824 1.176768 0.503074
+GGGGGA 69.104065 1.100851 1.142683 0.481376
+GGGGGC 63.275229 0.875503 1.030947 0.412525
+GGGGGG 68.203579 1.269693 1.073591 0.438383
+GGGGGT 68.001244 1.357986 1.340378 0.611556
+GGGGTA 61.948736 2.558987 1.14554 0.483182
+GGGGTC 56.143314 1.437935 1.398169 0.651531
+GGGGTG 61.044741 1.935472 1.241187 0.544943
+GGGGTT 57.954823 2.008723 1.442545 0.682793
+GGGTAA 60.534215 1.543418 0.895432 0.333921
+GGGTAC 56.548366 0.891218 0.883436 0.327233
+GGGTAG 59.971463 1.925703 0.978798 0.381624
+GGGTAT 58.420233 1.060696 0.916502 0.345776
+GGGTCA 52.419326 1.073387 1.119614 0.466872
+GGGTCC 50.415268 1.318955 1.113705 0.463181
+GGGTCG 52.073403 0.878337 1.010683 0.400422
+GGGTCT 51.475743 0.935102 1.018339 0.40498
+GGGTGA 56.25038 0.893986 1.001849 0.395184
+GGGTGC 52.512041 0.725473 1.131865 0.474556
+GGGTGG 55.787408 1.010779 0.94626 0.362753
+GGGTGT 54.506872 0.776709 1.084147 0.444864
+GGGTTA 50.550511 0.911166 1.095378 0.451795
+GGGTTC 46.987301 1.175017 1.373551 0.634399
+GGGTTG 49.892755 0.890913 0.989363 0.387819
+GGGTTT 48.168395 1.369837 1.271935 0.565318
+GGTAAA 63.568858 1.030695 0.849559 0.308593
+GGTAAC 60.037294 0.935845 0.848281 0.307897
+GGTAAG 63.971463 0.997728 0.923179 0.349562
+GGTAAT 62.870363 0.965494 0.961353 0.371467
+GGTACA 59.193024 1.32096 0.952085 0.366108
+GGTACC 57.256515 1.049758 0.77654 0.269675
+GGTACG 59.122176 1.424668 0.899845 0.336393
+GGTACT 58.450025 1.211413 0.858118 0.313268
+GGTAGA 63.117583 0.905383 0.912119 0.343299
+GGTAGC 60.07989 0.842223 0.866371 0.317798
+GGTAGG 62.83511 0.959141 0.889796 0.330774
+GGTAGT 61.970139 1.047607 1.123799 0.469492
+GGTATA 58.76896 0.79677 0.750081 0.25601
+GGTATC 56.22724 0.887837 0.890057 0.330919
+GGTATG 58.058795 0.843929 0.804322 0.284276
+GGTATT 57.037408 1.167982 1.066199 0.433863
+GGTCAA 60.560835 1.730136 1.200524 0.518384
+GGTCAC 58.590338 1.361564 1.033959 0.414334
+GGTCAG 60.5633 1.993936 1.321157 0.598449
+GGTCAT 60.217766 1.828787 1.198094 0.516811
+GGTCCA 56.278495 1.967256 1.197389 0.516355
+GGTCCC 55.301509 1.6789 1.149515 0.485699
+GGTCCG 56.550685 2.367178 1.346325 0.61563
+GGTCCT 55.814112 1.52003 1.130628 0.473778
+GGTCGA 59.768208 1.860881 1.255678 0.554514
+GGTCGC 57.975324 1.153033 1.098473 0.453711
+GGTCGG 58.930942 1.921347 1.284264 0.573557
+GGTCGT 58.404512 1.451798 1.317943 0.596266
+GGTCTA 56.362033 1.176985 1.010077 0.400062
+GGTCTC 54.410852 0.691601 0.928852 0.352789
+GGTCTG 55.736607 1.131032 0.929096 0.352928
+GGTCTT 54.753739 1.01556 1.037917 0.416715
+GGTGAA 61.030805 2.190588 1.258168 0.556165
+GGTGAC 56.304213 1.560903 0.803912 0.284059
+GGTGAG 59.81191 1.979763 1.169964 0.498717
+GGTGAT 59.15228 2.068712 1.134439 0.476175
+GGTGCA 56.461676 2.61176 1.330828 0.605031
+GGTGCC 53.726753 1.91504 1.106112 0.458452
+GGTGCG 55.500559 2.250515 1.244245 0.546958
+GGTGCT 55.310536 1.733529 1.136175 0.477269
+GGTGGA 58.864342 1.378772 1.128187 0.472245
+GGTGGC 55.514774 0.769199 0.922555 0.349208
+GGTGGG 58.164042 1.486936 0.986421 0.38609
+GGTGGT 57.859171 1.220715 0.960957 0.371237
+GGTGTA 52.816828 0.991454 0.857229 0.312781
+GGTGTC 48.359297 1.328823 0.955947 0.368338
+GGTGTG 51.792991 1.099554 0.869744 0.319656
+GGTGTT 49.944505 1.31504 0.951728 0.365902
+GGTTAA 54.728658 1.830325 1.062899 0.43185
+GGTTAC 52.293611 1.5105 0.936514 0.357163
+GGTTAG 54.317075 1.888916 1.028761 0.411213
+GGTTAT 53.550199 1.659158 0.922659 0.349267
+GGTTCA 48.598959 2.019104 1.251991 0.552074
+GGTTCC 47.092419 1.905696 1.215049 0.52782
+GGTTCG 48.484435 1.851728 1.185977 0.508991
+GGTTCT 48.146794 1.686745 1.011485 0.400898
+GGTTGA 51.287479 1.167884 1.056854 0.428172
+GGTTGC 48.325195 0.818252 1.030547 0.412284
+GGTTGG 50.890332 1.124155 0.890082 0.330933
+GGTTGT 50.007229 0.981863 0.80614 0.285241
+GGTTTA 47.137243 1.212857 1.041863 0.419094
+GGTTTC 43.65926 0.804752 0.929846 0.353355
+GGTTTG 46.253841 0.855531 0.79726 0.28054
+GGTTTT 44.613237 0.798052 0.716824 0.239174
+GTAAAA 63.594689 0.972175 0.790445 0.276951
+GTAAAC 59.329465 1.025048 0.842796 0.304915
+GTAAAG 63.549134 0.963449 0.821328 0.293339
+GTAAAT 62.274417 0.80058 0.984458 0.384938
+GTAACA 58.19293 0.91437 0.801948 0.283018
+GTAACC 55.763266 0.960328 0.829418 0.297684
+GTAACG 57.855707 0.885942 0.79522 0.279464
+GTAACT 57.174505 0.80879 0.71188 0.236704
+GTAAGA 64.41955 1.339126 0.832188 0.299177
+GTAAGC 60.134154 1.167084 0.940017 0.359169
+GTAAGG 63.227434 0.928286 0.855914 0.312062
+GTAAGT 62.129594 1.623602 1.144492 0.482519
+GTAATA 58.031883 1.029006 0.827697 0.296758
+GTAATC 55.056105 1.770056 1.139715 0.479501
+GTAATG 57.487469 1.339608 0.920177 0.347859
+GTAATT 55.948408 1.941863 1.125344 0.470461
+GTACAA 65.037439 0.993603 0.956603 0.368717
+GTACAC 62.634813 1.045396 0.775133 0.268942
+GTACAG 65.199619 1.669074 0.996549 0.392052
+GTACAT 64.527738 1.152668 1.04381 0.420269
+GTACCA 60.699854 1.206091 0.891508 0.331729
+GTACCC 59.021518 1.023082 0.811173 0.287916
+GTACCG 60.514754 1.320995 0.85161 0.309711
+GTACCT 59.753872 1.067958 0.783455 0.273285
+GTACGA 64.397935 1.408517 0.992387 0.389598
+GTACGC 61.497959 0.892129 0.833086 0.299661
+GTACGG 63.617468 1.36604 0.977355 0.380779
+GTACGT 62.366534 1.261641 1.089832 0.448368
+GTACTA 60.359157 0.668906 0.702558 0.23207
+GTACTC 58.037142 1.243779 0.70277 0.232175
+GTACTG 59.53987 0.994691 0.878071 0.324258
+GTACTT 58.353737 1.648231 1.1107 0.461308
+GTAGAA 66.64853 1.679822 1.032284 0.413328
+GTAGAC 60.874943 0.895052 0.737412 0.249552
+GTAGAG 66.097869 2.092376 1.010745 0.400458
+GTAGAT 64.324881 1.626735 1.088285 0.447414
+GTAGCA 61.34384 1.573864 0.895524 0.333973
+GTAGCC 58.43674 0.895514 0.784794 0.273986
+GTAGCG 61.610735 1.866752 0.95387 0.367138
+GTAGCT 61.285507 2.119859 0.923368 0.349669
+GTAGGA 64.135581 1.494958 0.955459 0.368055
+GTAGGC 59.117999 0.913617 0.951034 0.365502
+GTAGGG 63.371454 1.016801 0.843401 0.305243
+GTAGGT 61.938313 0.908633 0.923417 0.349697
+GTAGTA 55.812412 1.094703 0.934792 0.356178
+GTAGTC 50.71345 1.642545 1.225236 0.534472
+GTAGTG 55.350388 1.240779 1.049091 0.423463
+GTAGTT 52.842815 1.677443 1.216606 0.528835
+GTATAA 59.9992 1.28513 0.723812 0.24268
+GTATAC 56.443247 0.737452 0.691288 0.226508
+GTATAG 59.787803 0.991877 0.740771 0.251259
+GTATAT 58.021462 1.253308 0.72938 0.245486
+GTATCA 54.307619 0.89997 0.874362 0.322205
+GTATCC 52.453032 0.866766 0.994604 0.390905
+GTATCG 54.211564 0.868718 0.844239 0.305699
+GTATCT 53.474959 0.72599 0.720008 0.240769
+GTATGA 55.402019 0.883566 0.912205 0.343348
+GTATGC 51.330497 1.0873 1.164599 0.49529
+GTATGG 55.213914 0.755308 0.825764 0.295719
+GTATGT 53.547073 0.822909 0.895432 0.333921
+GTATTA 50.552168 0.952378 0.99629 0.391899
+GTATTC 46.539148 1.349561 1.350713 0.618643
+GTATTG 49.812135 0.86881 0.940948 0.359703
+GTATTT 47.520191 1.53574 1.015794 0.403463
+GTCAAA 62.965139 1.251397 0.957566 0.369274
+GTCAAC 59.381025 1.089154 0.888641 0.33013
+GTCAAG 63.294314 0.896991 0.891992 0.331999
+GTCAAT 62.577815 0.990881 1.077599 0.44084
+GTCACA 61.649926 1.032586 0.858606 0.313535
+GTCACC 59.805971 0.990682 0.787652 0.275484
+GTCACG 61.253703 0.993232 0.812096 0.288407
+GTCACT 60.875986 1.083427 0.840399 0.303615
+GTCAGA 64.815205 0.998876 0.927489 0.352013
+GTCAGC 61.913763 1.697217 1.046796 0.422074
+GTCAGG 64.364409 0.879553 0.989353 0.387813
+GTCAGT 63.643315 1.088552 1.360573 0.625429
+GTCATA 61.737381 1.312467 0.90532 0.339467
+GTCATC 58.562084 1.685547 0.998833 0.3934
+GTCATG 60.841296 1.342107 1.041745 0.419022
+GTCATT 59.88386 1.998973 1.255546 0.554427
+GTCCAA 65.173515 1.211455 1.138057 0.478455
+GTCCAC 62.682869 0.826012 0.868968 0.319228
+GTCCAG 65.751522 1.603692 1.247571 0.549153
+GTCCAT 65.19407 1.154659 1.151584 0.487011
+GTCCCA 62.905313 1.665922 1.194686 0.514607
+GTCCCC 60.787387 1.223117 1.049952 0.423984
+GTCCCG 62.266646 1.615019 1.102555 0.456243
+GTCCCT 61.780715 1.792399 1.169323 0.498307
+GTCCGA 65.197342 1.356555 1.095091 0.451617
+GTCCGC 62.769529 0.983019 0.983506 0.38438
+GTCCGG 64.646135 1.387184 1.250335 0.550978
+GTCCGT 63.695053 1.496429 1.46844 0.701261
+GTCCTA 61.493462 1.223218 1.082687 0.443966
+GTCCTC 59.240982 0.764154 0.85912 0.313816
+GTCCTG 60.890949 0.930868 0.978779 0.381612
+GTCCTT 59.891063 1.151465 1.313505 0.593257
+GTCGAA 66.40728 1.79631 1.205885 0.52186
+GTCGAC 62.111011 0.883405 0.8411 0.303995
+GTCGAG 66.117405 1.414328 1.102279 0.456071
+GTCGAT 64.677894 1.222824 1.140074 0.479728
+GTCGCA 62.936743 1.782037 1.08958 0.448213
+GTCGCC 60.762533 1.208015 0.835356 0.300886
+GTCGCG 62.738577 1.611857 0.981903 0.383441
+GTCGCT 62.353726 1.537882 1.026337 0.40976
+GTCGGA 62.971679 0.966209 1.02588 0.409487
+GTCGGC 58.805249 1.427275 1.166537 0.496527
+GTCGGG 62.218569 1.07998 1.018082 0.404827
+GTCGGT 61.288969 1.076053 1.237676 0.542632
+GTCGTA 54.282604 2.319985 1.208153 0.523333
+GTCGTC 49.024967 2.37322 1.496762 0.721646
+GTCGTG 53.415626 2.119373 1.244335 0.547017
+GTCGTT 50.58595 2.363325 1.475059 0.706008
+GTCTAA 61.614895 1.36715 1.035754 0.415413
+GTCTAC 58.103605 0.66627 0.702683 0.232132
+GTCTAG 62.577761 1.57688 1.074256 0.43879
+GTCTAT 60.25429 1.054696 0.871442 0.320592
+GTCTCA 57.587584 1.44077 0.876447 0.323358
+GTCTCC 56.056095 1.448593 0.853776 0.310893
+GTCTCG 57.482023 1.070743 0.92837 0.352514
+GTCTCT 56.675507 0.986329 0.696623 0.229135
+GTCTGA 56.186506 1.528015 0.911027 0.342683
+GTCTGC 50.947724 1.087676 1.090005 0.448475
+GTCTGG 55.937081 0.885106 0.816034 0.290508
+GTCTGT 54.112992 0.777579 0.874758 0.322424
+GTCTTA 51.035434 0.981194 0.988869 0.387528
+GTCTTC 45.99755 1.23541 1.202794 0.519855
+GTCTTG 50.150042 1.048415 0.848414 0.307969
+GTCTTT 47.207397 1.457268 0.962284 0.372006
+GTGAAA 68.840539 1.266992 1.367352 0.630109
+GTGAAC 63.926373 1.294427 1.215519 0.528127
+GTGAAG 68.912891 1.450446 1.402177 0.654334
+GTGAAT 67.223336 1.608534 1.554517 0.763815
+GTGACA 60.374435 1.035224 0.880754 0.325744
+GTGACC 57.460399 0.989518 0.811131 0.287893
+GTGACG 59.639569 1.09692 0.876178 0.323209
+GTGACT 59.382211 0.87239 0.841441 0.30418
+GTGAGA 66.8522 1.237804 1.219175 0.530511
+GTGAGC 62.453048 1.748759 1.169838 0.498636
+GTGAGG 66.194888 1.176824 1.13013 0.473465
+GTGAGT 64.896916 1.484621 1.5798 0.782525
+GTGATA 59.550452 1.342992 1.048932 0.423366
+GTGATC 55.530972 1.470439 1.111863 0.462032
+GTGATG 58.880544 1.47894 1.126455 0.471157
+GTGATT 57.098171 2.393768 1.280314 0.570913
+GTGCAA 68.25663 1.489013 1.420905 0.667487
+GTGCAC 65.507556 1.108645 1.196624 0.51586
+GTGCAG 68.906535 1.497136 1.372659 0.633781
+GTGCAT 67.450452 1.368366 1.549473 0.760101
+GTGCCA 63.437211 1.597284 1.278127 0.569451
+GTGCCC 61.52794 1.117241 0.962973 0.372406
+GTGCCG 62.919576 1.622644 1.244983 0.547445
+GTGCCT 63.06375 1.358332 1.147292 0.484291
+GTGCGA 67.781996 1.514867 1.315382 0.594529
+GTGCGC 64.214282 1.28576 1.076625 0.440243
+GTGCGG 66.507209 1.524234 1.37283 0.633899
+GTGCGT 64.777092 1.413426 1.548366 0.759287
+GTGCTA 62.931138 0.948249 0.955171 0.367889
+GTGCTC 60.18469 0.966938 1.167513 0.49715
+GTGCTG 61.671663 1.23424 1.242472 0.545789
+GTGCTT 60.696923 1.210337 1.532174 0.747407
+GTGGAA 67.509521 2.61176 1.588732 0.789172
+GTGGAC 60.715289 1.684074 0.927518 0.352029
+GTGGAG 66.704057 2.585949 1.541712 0.754398
+GTGGAT 65.057484 1.719381 1.391849 0.647118
+GTGGCA 61.330421 2.231239 1.233683 0.540009
+GTGGCC 58.855318 1.660777 1.006409 0.397885
+GTGGCG 61.041249 2.44591 1.23719 0.542313
+GTGGCT 60.806255 2.358395 1.176273 0.502756
+GTGGGA 62.569913 1.596771 1.246173 0.54823
+GTGGGC 56.439716 0.9383 1.169146 0.498194
+GTGGGG 61.57864 1.397679 1.109759 0.460721
+GTGGGT 61.074004 1.363084 1.111644 0.461896
+GTGGTA 54.756384 1.02082 1.034899 0.414899
+GTGGTC 49.027697 1.205001 1.153401 0.488164
+GTGGTG 53.997532 1.143684 0.981367 0.383127
+GTGGTT 50.927872 1.263179 1.158693 0.491527
+GTGTAA 55.997064 1.254323 0.917589 0.346392
+GTGTAC 51.929245 0.845867 0.886567 0.328975
+GTGTAG 55.524878 1.36671 0.878482 0.324485
+GTGTAT 54.315247 1.736969 0.854405 0.311237
+GTGTCA 49.032328 1.654557 1.208961 0.523858
+GTGTCC 46.355551 1.081693 1.124276 0.469791
+GTGTCG 48.503915 1.636504 1.096653 0.452584
+GTGTCT 47.807966 1.266218 0.921332 0.348513
+GTGTGA 51.757362 0.835884 0.96045 0.370943
+GTGTGC 47.824645 0.781621 1.068301 0.435147
+GTGTGG 50.936097 0.913917 0.957026 0.368962
+GTGTGT 49.922984 0.836727 0.78795 0.275641
+GTGTTA 46.688017 0.805 0.985128 0.385331
+GTGTTC 43.16903 0.870146 1.023579 0.40811
+GTGTTG 46.093433 0.717457 0.922456 0.349152
+GTGTTT 44.041686 0.778569 0.883675 0.327366
+GTTAAA 63.052093 1.177957 1.056233 0.427794
+GTTAAC 59.552539 0.879427 0.827574 0.296692
+GTTAAG 63.850551 1.581969 1.162304 0.493827
+GTTAAT 62.489347 1.192047 1.131658 0.474426
+GTTACA 59.640868 1.618078 1.159831 0.492252
+GTTACC 57.676917 1.217501 0.952998 0.366634
+GTTACG 59.466723 1.666118 1.135948 0.477126
+GTTACT 59.209628 1.345115 1.065727 0.433575
+GTTAGA 63.080115 1.208771 1.141873 0.480863
+GTTAGC 59.977644 0.842908 0.941786 0.360183
+GTTAGG 62.827171 1.337832 1.137492 0.478099
+GTTAGT 61.730734 1.18983 1.286162 0.574829
+GTTATA 58.755316 0.862995 0.85099 0.309373
+GTTATC 56.006308 1.19931 0.909286 0.341701
+GTTATG 58.02577 1.033213 0.923131 0.349534
+GTTATT 56.838482 1.109513 1.101966 0.455877
+GTTCAA 61.525858 1.9698 1.547188 0.758421
+GTTCAC 59.255218 1.735609 1.223587 0.533393
+GTTCAG 61.873567 2.455494 1.587217 0.788043
+GTTCAT 61.904772 1.831715 1.471478 0.703438
+GTTCCA 58.226791 2.327286 1.563663 0.770566
+GTTCCC 56.116708 1.97558 1.478611 0.708559
+GTTCCG 58.092723 2.308913 1.571773 0.776569
+GTTCCT 57.033317 2.124822 1.519679 0.738283
+GTTCGA 61.140834 1.99508 1.560223 0.768025
+GTTCGC 59.362352 1.407517 1.240389 0.544418
+GTTCGG 60.646412 1.967092 1.585464 0.786737
+GTTCGT 59.833797 1.910849 1.624932 0.816297
+GTTCTA 57.531614 1.491459 1.18394 0.50768
+GTTCTC 55.542421 0.927415 0.92199 0.348887
+GTTCTG 56.833061 1.360019 1.14068 0.48011
+GTTCTT 55.44376 1.159415 1.202028 0.519358
+GTTGAA 60.431597 2.61176 1.50817 0.729912
+GTTGAC 54.975393 1.537306 0.946796 0.363061
+GTTGAG 59.040768 2.474864 1.282131 0.572129
+GTTGAT 58.156869 2.504873 1.235988 0.541523
+GTTGCA 55.635329 2.61176 1.384883 0.642266
+GTTGCC 53.394797 1.952744 1.164528 0.495245
+GTTGCG 55.541034 2.61176 1.394893 0.649242
+GTTGCT 54.990328 2.61176 1.323978 0.600366
+GTTGGA 58.120247 1.621211 1.320212 0.597807
+GTTGGC 54.705602 0.934687 1.061131 0.430773
+GTTGGG 57.402188 1.598148 1.145521 0.48317
+GTTGGT 57.118787 1.424712 1.097991 0.453413
+GTTGTA 51.670592 0.901118 0.868568 0.319007
+GTTGTC 46.948276 1.142102 0.949662 0.364711
+GTTGTG 50.676744 1.248382 0.797407 0.280618
+GTTGTT 48.861971 1.528132 0.908867 0.341465
+GTTTAA 55.184326 2.061416 1.327226 0.602577
+GTTTAC 52.367955 1.550403 1.026886 0.410089
+GTTTAG 55.402274 2.499319 1.321634 0.598773
+GTTTAT 53.941522 1.956485 1.102928 0.456474
+GTTTCA 49.705039 2.283445 1.187615 0.510046
+GTTTCC 47.531973 1.637162 1.187473 0.509954
+GTTTCG 49.512766 2.160549 1.238159 0.54295
+GTTTCT 48.677824 1.875926 1.027139 0.410241
+GTTTGA 51.27616 1.065803 1.122748 0.468834
+GTTTGC 48.139062 0.812552 1.081429 0.443192
+GTTTGG 51.010369 1.380943 1.011097 0.400668
+GTTTGT 50.358993 1.158654 0.882616 0.326778
+GTTTTA 46.783813 0.975118 0.956425 0.368614
+GTTTTC 43.44678 0.766036 0.817454 0.291266
+GTTTTG 46.281474 0.855379 0.712172 0.236849
+GTTTTT 44.286924 0.66951 0.653449 0.208168
+TAAAAA 63.426346 1.00145 0.731502 0.246558
+TAAAAC 58.592611 0.97466 0.837054 0.301804
+TAAAAG 63.475796 0.770718 0.731629 0.246622
+TAAAAT 62.023093 0.870504 0.958706 0.369933
+TAAACA 57.212702 0.904162 0.892897 0.332505
+TAAACC 54.808939 0.977183 0.960687 0.37108
+TAAACG 56.95762 0.899306 0.859656 0.31411
+TAAACT 56.365226 0.780958 0.766382 0.264401
+TAAAGA 63.394183 0.959244 0.80124 0.282643
+TAAAGC 59.081508 0.892327 0.908931 0.341501
+TAAAGG 62.374635 0.896631 0.783015 0.273055
+TAAAGT 61.284344 0.935746 1.08203 0.443562
+TAAATA 56.85771 0.796771 0.863206 0.316058
+TAAATC 53.0632 1.033629 1.161261 0.493163
+TAAATG 56.23705 1.205203 0.978026 0.381172
+TAAATT 54.296629 1.497293 1.168484 0.497771
+TAACAA 64.053881 1.249595 0.851244 0.309511
+TAACAC 61.548825 0.876929 0.749211 0.255565
+TAACAG 64.383416 1.887841 0.983392 0.384313
+TAACAT 63.898119 1.077595 0.971358 0.377281
+TAACCA 59.871206 1.616429 0.923385 0.349679
+TAACCC 57.833256 1.201966 0.854574 0.311329
+TAACCG 59.755242 1.745532 0.939532 0.358891
+TAACCT 58.991459 1.298084 0.886763 0.329084
+TAACGA 63.239887 1.573181 0.960612 0.371037
+TAACGC 60.51164 0.981825 0.807144 0.285773
+TAACGG 62.605318 1.446791 0.951354 0.365686
+TAACGT 61.37883 1.173373 1.137637 0.478191
+TAACTA 58.91518 0.876244 0.642829 0.203113
+TAACTC 56.491688 0.754899 0.671781 0.216989
+TAACTG 58.045878 0.94669 0.732223 0.246922
+TAACTT 56.62631 0.960062 0.942115 0.360372
+TAAGAA 68.35648 2.080823 1.082526 0.443867
+TAAGAC 61.448302 0.892758 0.774396 0.268559
+TAAGAG 67.795517 2.389559 1.076365 0.440083
+TAAGAT 65.528694 1.677489 1.090294 0.448653
+TAAGCA 62.478989 2.308329 1.067845 0.434868
+TAAGCC 58.749687 1.11901 0.884531 0.327842
+TAAGCG 62.619739 2.61176 1.121599 0.468114
+TAAGCT 61.88476 2.151423 0.984638 0.385044
+TAAGGA 64.898144 1.79963 0.946107 0.362665
+TAAGGC 59.468633 0.923851 1.031075 0.412601
+TAAGGG 62.914168 1.084649 0.787642 0.275479
+TAAGGT 62.617771 1.013482 0.932027 0.354599
+TAAGTA 55.400628 1.440501 1.061041 0.430719
+TAAGTC 49.959339 1.325182 1.535964 0.750182
+TAAGTG 54.697498 1.34305 1.046852 0.422108
+TAAGTT 51.387 1.686673 1.359706 0.624831
+TAATAA 59.308919 1.482608 0.849915 0.308787
+TAATAC 55.40577 0.767778 0.815269 0.290099
+TAATAG 59.229947 1.763132 0.887904 0.329719
+TAATAT 57.701806 1.393364 0.787683 0.2755
+TAATCA 53.604688 1.292251 1.013776 0.402261
+TAATCC 51.457778 1.042971 1.06927 0.435739
+TAATCG 53.437447 1.238589 0.98136 0.383123
+TAATCT 52.500328 0.938021 0.909435 0.341785
+TAATGA 54.249836 0.914925 1.031722 0.41299
+TAATGC 50.625309 1.158006 1.395271 0.649506
+TAATGG 54.22321 0.809808 0.854186 0.311117
+TAATGT 53.01172 0.729343 0.926973 0.351719
+TAATTA 49.903093 1.010014 1.250061 0.550798
+TAATTC 45.790158 1.087662 1.412281 0.66142
+TAATTG 49.229541 0.993905 1.062644 0.431695
+TAATTT 46.505153 1.031374 1.198882 0.517321
+TACAAA 64.986256 1.436096 0.885817 0.328557
+TACAAC 60.477461 1.104713 0.914812 0.34482
+TACAAG 65.383067 0.991324 0.89796 0.335337
+TACAAT 64.081055 1.094147 1.124742 0.470083
+TACACA 64.068794 1.114304 0.807197 0.285802
+TACACC 61.196352 0.713988 0.751744 0.256862
+TACACG 63.354222 1.006001 0.764002 0.26317
+TACACT 63.102335 0.878485 0.782747 0.272915
+TACAGA 66.402178 1.313288 0.928804 0.352762
+TACAGC 62.936544 2.272482 0.940278 0.359319
+TACAGG 66.206525 0.994137 0.925533 0.3509
+TACAGT 65.21733 1.235639 1.383221 0.64111
+TACATA 62.665764 1.081974 0.799972 0.281973
+TACATC 58.955259 1.594255 0.950096 0.364961
+TACATG 61.990571 1.33955 0.944111 0.361518
+TACATT 60.004688 2.208692 1.306766 0.588697
+TACCAA 66.733394 1.029792 0.943571 0.361208
+TACCAC 64.307506 0.72211 0.717195 0.23936
+TACCAG 68.002533 1.181591 1.000645 0.394471
+TACCAT 67.047074 1.011216 0.98589 0.385778
+TACCCA 64.707492 1.381543 0.87003 0.319813
+TACCCC 62.691131 0.947405 0.710576 0.236054
+TACCCG 64.331474 1.896128 0.863648 0.316301
+TACCCT 64.063411 1.196641 0.861736 0.315251
+TACCGA 67.067485 1.169948 0.901763 0.337469
+TACCGC 64.369574 0.832393 0.701408 0.2315
+TACCGG 66.601154 1.134825 0.985889 0.385778
+TACCGT 65.429607 1.146725 1.507017 0.729076
+TACCTA 63.399549 0.88398 0.688646 0.225211
+TACCTC 60.641825 1.275758 0.71164 0.236584
+TACCTG 62.242402 0.963304 0.881877 0.326368
+TACCTT 60.725988 1.538089 1.137749 0.478261
+TACGAA 69.484555 1.645567 1.036702 0.415983
+TACGAC 63.887496 1.162646 0.786845 0.275061
+TACGAG 69.05477 1.366923 0.963466 0.372692
+TACGAT 67.222633 1.02136 1.135668 0.476949
+TACGCA 65.605848 1.588244 0.909955 0.342078
+TACGCC 63.327694 1.225046 0.696335 0.228993
+TACGCG 65.474071 1.599979 0.890801 0.331334
+TACGCT 65.084897 1.287264 0.915208 0.345044
+TACGGA 64.82947 1.176639 0.898002 0.33536
+TACGGC 58.983522 1.176028 1.060527 0.430406
+TACGGG 63.526568 1.312738 0.907016 0.340422
+TACGGT 62.781502 1.301117 1.234203 0.54035
+TACGTA 54.27205 1.668493 1.31982 0.597541
+TACGTC 47.907204 2.251567 1.614804 0.808677
+TACGTG 53.083064 1.976503 1.293766 0.579934
+TACGTT 50.04645 2.489868 1.559829 0.767734
+TACTAA 63.486176 1.198128 0.711129 0.236329
+TACTAC 59.699424 0.742467 0.670387 0.216313
+TACTAG 63.490155 1.100958 0.745918 0.253882
+TACTAT 61.536221 0.763772 0.7592 0.260693
+TACTCA 59.024719 1.209912 0.779494 0.271215
+TACTCC 56.603267 0.730355 0.727721 0.244648
+TACTCG 58.962802 1.404206 0.763367 0.262842
+TACTCT 57.746953 0.827205 0.703975 0.232772
+TACTGA 55.927351 1.291473 0.957953 0.369498
+TACTGC 51.356112 1.036199 1.178674 0.504296
+TACTGG 56.494162 0.744355 0.806111 0.285225
+TACTGT 54.775724 0.971474 0.99714 0.3924
+TACTTA 51.195143 1.013513 1.110198 0.460995
+TACTTC 46.269845 1.121733 1.408036 0.658439
+TACTTG 50.405704 0.872782 1.104013 0.457148
+TACTTT 47.313705 1.524181 1.286314 0.574931
+TAGAAA 70.119311 1.338791 1.307561 0.589234
+TAGAAC 64.842627 1.643709 0.9847 0.38508
+TAGAAG 70.426031 1.339281 1.26639 0.561625
+TAGAAT 68.883219 1.438652 1.451744 0.689335
+TAGACA 62.040654 1.385615 0.71352 0.237522
+TAGACC 57.757602 0.665098 0.808189 0.286329
+TAGACG 60.278736 0.914066 0.72989 0.245743
+TAGACT 59.681939 0.826756 0.792112 0.277827
+TAGAGA 68.709506 1.135986 1.078378 0.441318
+TAGAGC 62.847289 1.372047 0.993847 0.390458
+TAGAGG 67.881302 1.12486 1.134093 0.475958
+TAGAGT 65.941955 1.485908 1.419963 0.666823
+TAGATA 59.281567 1.069013 0.909699 0.341934
+TAGATC 55.005986 1.463818 1.285507 0.57439
+TAGATG 58.56231 1.097938 1.069611 0.435947
+TAGATT 56.950599 1.50177 1.253682 0.553192
+TAGCAA 68.596963 0.893693 1.002991 0.395859
+TAGCAC 65.806496 0.819627 0.950285 0.36507
+TAGCAG 68.961658 1.100078 1.105622 0.458148
+TAGCAT 67.895996 1.092536 1.240321 0.544373
+TAGCCA 63.75885 1.094964 0.801376 0.282716
+TAGCCC 61.734872 0.799353 0.703501 0.232537
+TAGCCG 63.390117 1.136528 0.797139 0.280477
+TAGCCT 63.120361 1.003887 0.8439 0.305515
+TAGCGA 68.145921 1.089042 0.969941 0.376455
+TAGCGC 64.515897 0.768045 0.868455 0.318945
+TAGCGG 66.973983 1.12268 0.974254 0.378969
+TAGCGT 65.634614 0.996094 1.531029 0.74657
+TAGCTA 63.054745 1.138656 0.818756 0.291962
+TAGCTC 60.303084 2.61176 0.856761 0.312525
+TAGCTG 61.851068 1.300842 1.003775 0.396323
+TAGCTT 60.099642 2.108361 1.329106 0.603858
+TAGGAA 72.288441 2.314555 1.370015 0.631951
+TAGGAC 65.046368 1.765196 0.919283 0.347351
+TAGGAG 71.401119 2.211138 1.576508 0.780081
+TAGGAT 69.420543 1.589098 1.328188 0.603232
+TAGGCA 66.994986 2.61176 1.253109 0.552814
+TAGGCC 62.212988 1.678233 0.885752 0.328521
+TAGGCG 65.447142 2.39413 1.274874 0.567279
+TAGGCT 64.620378 2.202954 1.145618 0.483231
+TAGGGA 67.627139 2.11046 1.152507 0.487597
+TAGGGC 60.600281 0.562686 1.058379 0.429099
+TAGGGG 66.192949 1.279096 0.992552 0.389696
+TAGGGT 65.706986 1.510779 1.092728 0.450157
+TAGGTA 58.442294 0.857546 0.930587 0.353778
+TAGGTC 52.447937 1.229444 1.280153 0.570806
+TAGGTG 57.354085 1.050836 1.026407 0.409802
+TAGGTT 54.207785 1.394368 1.177341 0.503441
+TAGTAA 58.453013 1.187233 0.881178 0.32598
+TAGTAC 54.020924 0.705828 0.934971 0.356281
+TAGTAG 57.936715 1.400844 1.071864 0.437326
+TAGTAT 56.52832 1.348451 0.869871 0.319726
+TAGTCA 51.431334 1.753418 1.152882 0.487835
+TAGTCC 48.823252 0.97263 1.030352 0.412167
+TAGTCG 51.232644 1.847477 1.094939 0.451524
+TAGTCT 50.145109 1.351282 1.018352 0.404988
+TAGTGA 53.602041 0.711575 0.955799 0.368252
+TAGTGC 50.113413 0.971751 1.318375 0.59656
+TAGTGG 53.487362 1.141241 0.924472 0.350297
+TAGTGT 52.357476 0.806522 0.869206 0.319359
+TAGTTA 48.556014 0.838119 1.102613 0.456278
+TAGTTC 45.083079 1.087221 1.222959 0.532983
+TAGTTG 47.886435 0.778848 0.980576 0.382663
+TAGTTT 45.818525 0.818936 1.013418 0.402048
+TATAAA 64.175516 0.86567 0.750095 0.256018
+TATAAC 59.88135 1.14624 0.692355 0.227033
+TATAAG 64.807543 0.941898 0.818733 0.29195
+TATAAT 63.453447 0.810077 0.955591 0.368132
+TATACA 61.055231 1.373865 0.852411 0.310148
+TATACC 58.451921 0.856431 0.671457 0.216831
+TATACG 60.682454 1.475863 0.768696 0.265599
+TATACT 59.640016 1.491437 0.726412 0.243989
+TATAGA 63.933308 0.830271 0.786493 0.274877
+TATAGC 60.53412 0.871265 0.790079 0.276759
+TATAGG 63.508874 0.803069 0.84327 0.305172
+TATAGT 62.654421 0.922199 1.130049 0.473414
+TATATA 59.252375 0.762476 0.645935 0.204587
+TATATC 55.450883 1.038364 0.769739 0.26614
+TATATG 58.514846 0.870036 0.733851 0.247746
+TATATT 56.569828 1.332845 0.924985 0.350588
+TATCAA 63.042567 1.456382 1.004477 0.396739
+TATCAC 60.648458 1.051612 0.782584 0.27283
+TATCAG 63.246797 2.015944 1.139908 0.479623
+TATCAT 63.287182 1.360935 1.09246 0.449991
+TATCCA 59.700776 1.916516 1.025638 0.409342
+TATCCC 58.137895 1.501681 0.981845 0.383407
+TATCCG 59.76407 1.745268 1.054292 0.426616
+TATCCT 59.012321 2.074216 0.962378 0.372061
+TATCGA 62.714774 1.707245 1.075121 0.43932
+TATCGC 60.398075 1.011627 0.850706 0.309218
+TATCGG 62.180661 1.713148 1.089136 0.447939
+TATCGT 61.088255 1.421719 1.330027 0.604486
+TATCTA 58.7605 1.053711 0.733004 0.247317
+TATCTC 56.256626 0.654461 0.667825 0.215075
+TATCTG 57.757808 1.004476 0.790154 0.276798
+TATCTT 56.358126 0.836911 0.945498 0.362315
+TATGAA 63.412359 2.317983 1.286903 0.575326
+TATGAC 57.086855 1.603576 0.858866 0.313678
+TATGAG 61.579014 2.467899 1.253265 0.552917
+TATGAT 61.204991 2.067497 1.208007 0.523238
+TATGCA 58.297645 2.61176 1.439055 0.680317
+TATGCC 56.248882 2.61176 1.223049 0.533041
+TATGCG 57.984393 2.61176 1.401389 0.653782
+TATGCT 57.725997 2.544856 1.173184 0.500777
+TATGGA 59.837924 1.455093 1.034812 0.414847
+TATGGC 55.808849 0.827668 0.958258 0.369674
+TATGGG 58.942195 1.13776 0.949302 0.364503
+TATGGT 58.438846 1.081928 0.973784 0.378695
+TATGTA 52.006846 0.84078 0.913924 0.344319
+TATGTC 46.85024 1.259932 1.042695 0.419596
+TATGTG 50.960922 0.83846 0.894607 0.33346
+TATGTT 48.394104 1.257915 0.956731 0.368791
+TATTAA 56.847883 1.997237 1.08612 0.446079
+TATTAC 53.368615 1.516165 0.982539 0.383813
+TATTAG 56.511058 1.601668 1.143717 0.482029
+TATTAT 55.311256 1.737399 0.952378 0.366277
+TATTCA 50.803847 2.087089 1.348546 0.617154
+TATTCC 48.946584 1.793606 1.199315 0.517601
+TATTCG 50.732572 2.431109 1.22974 0.537422
+TATTCT 49.903396 1.847548 1.223963 0.533639
+TATTGA 51.973089 1.117406 0.985104 0.385317
+TATTGC 48.651321 0.88642 1.052505 0.425531
+TATTGG 51.876043 1.079783 0.853428 0.310703
+TATTGT 51.143359 0.943354 0.788264 0.275805
+TATTTA 47.423698 0.983187 1.020548 0.406299
+TATTTC 43.798458 0.827014 1.01165 0.400997
+TATTTG 46.689497 0.770068 0.827966 0.296903
+TATTTT 44.560273 0.644742 0.787852 0.275589
+TCAAAA 63.234093 1.049218 0.823909 0.294723
+TCAAAC 58.496571 1.062457 0.864128 0.316564
+TCAAAG 63.266702 0.842827 0.878091 0.324268
+TCAAAT 61.764594 0.849486 1.036068 0.415602
+TCAACA 58.072063 0.894052 0.878135 0.324293
+TCAACC 55.783298 0.752204 0.935323 0.356482
+TCAACG 57.773558 0.850336 0.859181 0.31385
+TCAACT 57.389088 0.821496 0.787259 0.275278
+TCAAGA 64.736339 1.129961 0.852124 0.309991
+TCAAGC 59.644846 1.024863 0.92044 0.348007
+TCAAGG 63.139694 0.892552 0.83843 0.302549
+TCAAGT 62.081105 0.962464 1.251941 0.552041
+TCAATA 57.855914 0.906858 0.864101 0.31655
+TCAATC 54.427304 1.556252 1.119164 0.46659
+TCAATG 57.308485 1.287384 1.012677 0.401607
+TCAATT 55.655448 1.722319 1.225533 0.534666
+TCACAA 66.579086 0.971855 0.904361 0.338928
+TCACAC 63.880548 0.89022 0.729776 0.245686
+TCACAG 67.28337 1.174718 0.911505 0.342952
+TCACAT 66.182058 0.887586 0.971115 0.377139
+TCACCA 63.070371 1.185308 0.784069 0.273607
+TCACCC 61.658209 1.446469 0.728936 0.245261
+TCACCG 62.774594 1.112534 0.781025 0.272015
+TCACCT 62.437881 1.015022 0.789202 0.276298
+TCACGA 65.964855 1.193722 0.834929 0.300656
+TCACGC 63.445271 1.349601 0.761023 0.261633
+TCACGG 65.149767 1.030811 0.911479 0.342938
+TCACGT 63.933871 0.982453 1.250451 0.551056
+TCACTA 61.666126 1.674688 0.722049 0.241794
+TCACTC 58.548696 1.000576 0.756671 0.259392
+TCACTG 60.70581 1.002634 0.847655 0.307556
+TCACTT 59.124771 1.311659 1.12703 0.471518
+TCAGAA 67.582752 1.706655 1.004876 0.396976
+TCAGAC 60.450899 1.053168 0.858896 0.313694
+TCAGAG 66.028418 1.785938 0.96256 0.372166
+TCAGAT 63.847012 1.091785 1.02856 0.411093
+TCAGCA 61.535778 1.326068 0.978544 0.381475
+TCAGCC 58.615627 1.002361 0.844461 0.305819
+TCAGCG 61.043294 1.09916 0.950503 0.365196
+TCAGCT 60.923917 1.313384 0.923388 0.349681
+TCAGGA 63.883657 1.090758 0.986598 0.386194
+TCAGGC 58.548426 1.096606 1.167197 0.496949
+TCAGGG 62.739223 0.899728 0.826596 0.296166
+TCAGGT 61.854386 0.916909 0.989525 0.387914
+TCAGTA 54.529523 1.178831 1.149589 0.485746
+TCAGTC 49.320191 1.966069 1.471857 0.70371
+TCAGTG 54.278954 1.719574 1.215831 0.52833
+TCAGTT 51.076796 1.942724 1.460323 0.695454
+TCATAA 61.007135 0.864816 0.718762 0.240145
+TCATAC 57.046969 0.698836 0.805397 0.284846
+TCATAG 60.755652 0.918548 0.77907 0.270994
+TCATAT 59.223816 0.712544 0.765813 0.264107
+TCATCA 55.653878 0.91128 0.881793 0.326321
+TCATCC 53.494935 0.884684 1.068452 0.435239
+TCATCG 55.461148 0.893219 0.890888 0.331383
+TCATCT 54.673692 0.736062 0.791664 0.277592
+TCATGA 55.542374 1.029187 1.049157 0.423503
+TCATGC 50.899834 1.051232 1.458448 0.694115
+TCATGG 55.561269 0.927532 0.999537 0.393816
+TCATGT 53.734017 0.887529 1.094744 0.451403
+TCATTA 50.607238 1.090434 1.267914 0.562639
+TCATTC 46.003317 1.198616 1.559613 0.767574
+TCATTG 49.90372 1.118445 1.209756 0.524375
+TCATTT 47.161472 1.489886 1.342329 0.612891
+TCCAAA 65.19827 1.345686 0.951127 0.365555
+TCCAAC 59.997156 1.045882 0.98423 0.384804
+TCCAAG 65.245918 0.864267 0.987988 0.38701
+TCCAAT 63.816998 0.823002 1.128756 0.472602
+TCCACA 63.884889 1.245574 0.803643 0.283916
+TCCACC 61.383289 0.862949 0.807136 0.285769
+TCCACG 63.487289 0.867339 0.771828 0.267225
+TCCACT 62.929252 0.718026 0.816361 0.290682
+TCCAGA 66.644759 1.635653 0.955677 0.368181
+TCCAGC 62.398311 1.419474 1.019984 0.405962
+TCCAGG 66.361138 1.060995 0.94566 0.362408
+TCCAGT 65.527252 1.620865 1.493223 0.719089
+TCCATA 62.768433 1.132722 0.841329 0.304119
+TCCATC 59.06191 1.855102 1.138007 0.478424
+TCCATG 62.188149 1.33685 1.039353 0.41758
+TCCATT 60.373069 2.034307 1.270293 0.564224
+TCCCAA 68.093641 0.893804 0.958597 0.36987
+TCCCAC 65.446606 1.025205 0.797149 0.280482
+TCCCAG 69.107674 0.929513 0.971903 0.377598
+TCCCAT 68.087224 0.88048 1.199346 0.517621
+TCCCCA 66.406492 1.17207 0.778469 0.270681
+TCCCCC 64.39358 0.753692 0.662993 0.212744
+TCCCCG 66.275836 1.0671 0.832899 0.29956
+TCCCCT 65.811691 0.977908 0.823224 0.294356
+TCCCGA 68.79815 1.068086 0.917619 0.346409
+TCCCGC 65.679909 1.195545 0.808445 0.286465
+TCCCGG 68.071622 0.98559 0.961985 0.371833
+TCCCGT 66.821522 1.005284 1.462148 0.696759
+TCCCTA 64.822773 0.943447 0.743182 0.252487
+TCCCTC 61.301496 1.443026 0.768299 0.265394
+TCCCTG 63.457467 1.190949 0.974256 0.37897
+TCCCTT 61.726898 1.839164 1.264086 0.560093
+TCCGAA 69.307502 1.328187 0.935771 0.356738
+TCCGAC 63.609436 1.066417 0.804588 0.284417
+TCCGAG 68.983621 0.916938 0.890227 0.331014
+TCCGAT 66.922416 0.73089 1.161217 0.493134
+TCCGCA 65.983514 1.253146 0.870217 0.319916
+TCCGCC 63.152972 0.811572 0.727505 0.24454
+TCCGCG 65.462121 1.210047 0.84311 0.305085
+TCCGCT 65.019941 1.257941 0.905137 0.339365
+TCCGGA 64.321979 1.530982 0.941582 0.360066
+TCCGGC 58.729655 1.429891 1.236062 0.541571
+TCCGGG 63.504226 1.419875 1.036893 0.416098
+TCCGGT 62.351675 1.68414 1.231188 0.538371
+TCCGTA 53.269205 2.118033 1.355302 0.621798
+TCCGTC 47.685525 2.474407 1.583816 0.785511
+TCCGTG 52.759779 2.173264 1.482258 0.711183
+TCCGTT 49.562149 2.426495 1.587619 0.788342
+TCCTAA 63.852338 1.378322 0.702115 0.231851
+TCCTAC 60.198919 0.692516 0.666618 0.214492
+TCCTAG 64.530537 0.823288 0.800363 0.28218
+TCCTAT 62.279614 1.041375 0.762411 0.262349
+TCCTCA 59.810236 0.802158 0.733069 0.24735
+TCCTCC 57.76153 0.843835 0.81952 0.292371
+TCCTCG 59.864857 0.872988 0.79018 0.276812
+TCCTCT 58.850637 0.794176 0.696255 0.228954
+TCCTGA 56.258467 1.376451 1.011527 0.400923
+TCCTGC 51.345837 1.164163 1.306026 0.588197
+TCCTGG 56.688656 0.839422 0.883693 0.327376
+TCCTGT 54.695395 0.97686 1.101437 0.455549
+TCCTTA 51.358993 1.050612 1.180979 0.505777
+TCCTTC 45.930122 1.34414 1.435439 0.677754
+TCCTTG 50.604392 0.982854 1.0952 0.451685
+TCCTTT 47.839987 1.873321 1.407705 0.658207
+TCGAAA 69.233579 1.353776 1.182355 0.506661
+TCGAAC 63.459008 1.534432 1.078013 0.441094
+TCGAAG 69.388202 1.344913 1.142338 0.481157
+TCGAAT 67.561722 1.481068 1.445737 0.685061
+TCGACA 61.420579 0.823108 0.705257 0.233409
+TCGACC 58.200806 0.743171 0.787797 0.275561
+TCGACG 60.955967 0.85312 0.721057 0.241296
+TCGACT 60.111989 0.660805 0.799872 0.28192
+TCGAGA 67.535428 1.754172 1.01919 0.405488
+TCGAGC 61.368997 1.167284 1.076184 0.439972
+TCGAGG 66.432396 1.531904 1.002214 0.3954
+TCGAGT 64.637843 1.89475 1.303536 0.586516
+TCGATA 58.770067 1.232234 0.946659 0.362983
+TCGATC 54.495699 1.465502 1.367854 0.630456
+TCGATG 58.306733 1.375237 1.065237 0.433276
+TCGATT 56.350982 2.302316 1.390364 0.646083
+TCGCAA 69.609973 0.979951 1.078911 0.441645
+TCGCAC 66.450835 1.137065 1.026109 0.409624
+TCGCAG 70.158989 0.961654 1.06292 0.431863
+TCGCAT 68.768651 1.205315 1.307192 0.588985
+TCGCCA 65.545897 0.897073 0.726375 0.24397
+TCGCCC 63.260469 0.824198 0.696456 0.229053
+TCGCCG 65.342386 0.908281 0.753512 0.257769
+TCGCCT 64.671331 0.820424 0.855201 0.311672
+TCGCGA 69.191974 0.968244 0.957712 0.369358
+TCGCGC 65.386405 1.328746 0.946755 0.363038
+TCGCGG 67.991694 1.000552 1.076401 0.440105
+TCGCGT 66.457244 1.157336 1.561559 0.769011
+TCGCTA 64.045734 1.193971 0.888782 0.330209
+TCGCTC 60.253497 1.562549 0.98126 0.383064
+TCGCTG 62.862118 1.531143 0.99798 0.392897
+TCGCTT 60.906541 1.812522 1.239124 0.543585
+TCGGAA 67.988493 2.471754 1.265116 0.560778
+TCGGAC 59.627902 1.034743 0.885375 0.328312
+TCGGAG 66.711448 2.028459 1.161432 0.493272
+TCGGAT 64.476334 1.482891 1.17264 0.500429
+TCGGCA 62.000529 2.356098 1.220716 0.531517
+TCGGCC 57.651061 1.271631 1.029979 0.411943
+TCGGCG 61.32822 2.213143 1.151471 0.486939
+TCGGCT 61.71371 2.34484 1.160957 0.492969
+TCGGGA 61.249661 1.133168 1.084345 0.444986
+TCGGGC 54.851455 1.227944 1.460306 0.695442
+TCGGGG 60.359957 1.072864 0.978083 0.381205
+TCGGGT 60.133044 1.037786 1.070362 0.436407
+TCGGTA 52.944521 1.060539 1.182021 0.506446
+TCGGTC 47.099392 1.066339 1.590984 0.79085
+TCGGTG 52.615286 1.483955 1.199953 0.518014
+TCGGTT 48.937707 1.433235 1.521841 0.739859
+TCGTAA 54.81309 1.639708 1.12791 0.47207
+TCGTAC 50.729946 1.011334 1.120214 0.467247
+TCGTAG 54.438145 1.687388 1.152481 0.48758
+TCGTAT 52.694893 1.095406 1.093239 0.450472
+TCGTCA 47.445029 1.587879 1.334927 0.607829
+TCGTCC 45.212747 1.358334 1.400554 0.653198
+TCGTCG 47.351414 1.617131 1.336587 0.608963
+TCGTCT 46.518891 1.169641 1.117548 0.46558
+TCGTGA 50.043804 0.971345 1.226672 0.535412
+TCGTGC 46.420098 1.030429 1.413602 0.662348
+TCGTGG 49.533935 1.032522 1.1217 0.468177
+TCGTGT 48.553882 0.846617 0.99938 0.393724
+TCGTTA 45.19979 0.795834 1.228904 0.536874
+TCGTTC 41.809136 0.884985 1.276006 0.568034
+TCGTTG 44.608103 0.847008 1.064991 0.433126
+TCGTTT 42.706488 0.819986 1.021577 0.406913
+TCTAAA 65.471352 0.83233 0.818154 0.29164
+TCTAAC 61.45742 1.301525 0.721405 0.24147
+TCTAAG 66.319373 0.796805 0.82081 0.293062
+TCTAAT 64.70383 0.707771 1.022531 0.407483
+TCTACA 62.496664 1.235408 0.774011 0.268359
+TCTACC 60.048959 0.944833 0.652157 0.207551
+TCTACG 61.968663 1.18479 0.708115 0.234829
+TCTACT 61.456912 0.869886 0.743479 0.252638
+TCTAGA 65.222329 0.887888 0.860012 0.314305
+TCTAGC 61.393325 0.747776 0.945469 0.362298
+TCTAGG 65.276448 0.789223 0.803353 0.283762
+TCTAGT 63.666269 1.750361 1.200687 0.518489
+TCTATA 60.384953 1.384127 0.7498 0.255867
+TCTATC 56.668443 1.068577 0.882756 0.326856
+TCTATG 59.753669 1.043331 0.837383 0.301982
+TCTATT 57.982636 1.231662 1.035222 0.415093
+TCTCAA 65.126934 1.085362 0.971733 0.377499
+TCTCAC 62.561598 0.720217 0.696697 0.229172
+TCTCAG 66.398575 1.219456 0.988045 0.387044
+TCTCAT 65.361626 0.927971 0.95127 0.365638
+TCTCCA 62.373392 1.320576 0.987506 0.386727
+TCTCCC 60.462063 1.038149 0.759393 0.260793
+TCTCCG 62.210077 1.520711 1.007454 0.398504
+TCTCCT 61.973256 1.290692 0.924601 0.35037
+TCTCGA 65.338529 1.042041 0.928087 0.352353
+TCTCGC 62.345637 0.680042 0.696567 0.229108
+TCTCGG 64.70982 1.052287 0.943064 0.360917
+TCTCGT 63.409404 1.041053 1.313761 0.59343
+TCTCTA 60.6844 0.781498 0.642494 0.202954
+TCTCTC 58.28057 0.991597 0.672118 0.217152
+TCTCTG 59.870968 0.790935 0.814895 0.2899
+TCTCTT 58.32803 1.252919 1.076809 0.440355
+TCTGAA 61.802116 2.14229 1.167783 0.497323
+TCTGAC 54.700728 1.098629 0.855658 0.311922
+TCTGAG 60.007853 1.830523 1.020613 0.406338
+TCTGAT 59.219393 2.207422 1.104636 0.457534
+TCTGCA 56.842412 2.61176 1.318697 0.596778
+TCTGCC 54.081892 2.11063 1.14492 0.48279
+TCTGCG 56.499888 2.537988 1.363095 0.627169
+TCTGCT 55.651969 1.863158 1.174306 0.501496
+TCTGGA 59.454155 1.35215 1.040999 0.418572
+TCTGGC 54.944763 0.767837 0.919987 0.347751
+TCTGGG 58.169951 1.147097 0.837825 0.302221
+TCTGGT 57.799672 0.947499 0.875351 0.322752
+TCTGTA 51.429996 0.870039 0.896175 0.334337
+TCTGTC 46.151881 1.469624 1.03945 0.417638
+TCTGTG 50.450817 0.949694 0.908003 0.340978
+TCTGTT 48.211943 1.450939 1.003185 0.395974
+TCTTAA 56.510614 1.807401 1.04319 0.419895
+TCTTAC 53.169486 1.605007 0.91952 0.347486
+TCTTAG 56.180585 1.540957 0.892382 0.332217
+TCTTAT 54.536858 1.314856 0.933181 0.355258
+TCTTCA 49.988039 1.811537 1.260829 0.55793
+TCTTCC 47.88491 1.932754 1.322345 0.599256
+TCTTCG 50.032398 2.02789 1.313204 0.593053
+TCTTCT 49.233271 1.79826 1.097027 0.452815
+TCTTGA 51.490552 1.022513 0.974732 0.379248
+TCTTGC 48.243058 0.801289 1.092566 0.450056
+TCTTGG 51.644367 1.102436 0.955823 0.368266
+TCTTGT 50.284111 0.981541 0.759904 0.261056
+TCTTTA 46.605136 0.869437 1.022361 0.407382
+TCTTTC 43.296737 0.81484 1.073709 0.438455
+TCTTTG 46.075679 0.809494 0.841346 0.304129
+TCTTTT 44.193777 0.635146 0.769234 0.265878
+TGAAAA 64.734333 0.996281 0.930701 0.353843
+TGAAAC 60.570586 1.731378 1.156217 0.489953
+TGAAAG 64.742252 0.82596 0.952837 0.366542
+TGAAAT 63.503661 1.257561 1.229953 0.537561
+TGAACA 57.315196 1.066419 1.049779 0.423879
+TGAACC 54.47066 0.810325 1.118963 0.466465
+TGAACG 56.910747 0.956428 0.995695 0.391548
+TGAACT 56.152211 0.838931 0.935371 0.356509
+TGAAGA 64.267342 0.9963 0.998167 0.393007
+TGAAGC 60.228044 1.31134 1.187392 0.509902
+TGAAGG 63.471479 1.195949 0.983862 0.384589
+TGAAGT 62.38613 1.549676 1.367426 0.63016
+TGAATA 57.312936 1.183256 1.13144 0.474288
+TGAATC 54.382309 1.711941 1.406137 0.657108
+TGAATG 56.750173 1.293463 1.289432 0.577023
+TGAATT 55.351468 1.950316 1.527575 0.744045
+TGACAA 63.456592 0.923918 0.789303 0.276351
+TGACAC 61.63889 0.809825 0.721339 0.241437
+TGACAG 63.802954 1.095014 0.796191 0.279976
+TGACAT 63.38165 0.950955 0.821017 0.293173
+TGACCA 58.723374 1.068294 0.794193 0.278923
+TGACCC 57.215909 0.961848 0.84783 0.307651
+TGACCG 58.472821 1.145738 0.820745 0.293027
+TGACCT 58.555948 1.153296 0.801838 0.28296
+TGACGA 62.558391 1.070214 0.829509 0.297733
+TGACGC 60.67977 1.355844 0.778287 0.270586
+TGACGG 61.664551 1.043386 0.821099 0.293217
+TGACGT 60.822246 0.989615 0.940254 0.359305
+TGACTA 58.737134 0.728392 0.717514 0.239519
+TGACTC 56.190735 0.684705 0.705685 0.233621
+TGACTG 57.971301 0.78879 0.73794 0.24982
+TGACTT 56.665655 0.91873 1.061061 0.430731
+TGAGAA 68.435837 1.809792 0.988863 0.387525
+TGAGAC 62.043545 1.125689 0.940706 0.359564
+TGAGAG 67.101764 1.585925 1.006569 0.397979
+TGAGAT 65.509412 1.199971 1.102177 0.456008
+TGAGCA 61.356374 1.464666 1.003093 0.39592
+TGAGCC 58.488058 0.934443 0.900158 0.336568
+TGAGCG 60.757565 1.252066 1.018526 0.405092
+TGAGCT 60.366111 1.477563 0.898143 0.335439
+TGAGGA 65.002705 1.070571 0.972513 0.377953
+TGAGGC 60.265757 0.832612 1.095638 0.451956
+TGAGGG 63.675159 1.098654 0.895842 0.33415
+TGAGGT 63.26186 0.940985 1.152035 0.487297
+TGAGTA 57.005202 1.402351 1.051924 0.425179
+TGAGTC 51.871613 1.300963 1.3013 0.585008
+TGAGTG 56.326043 1.482657 1.148242 0.484892
+TGAGTT 53.463824 1.760498 1.448767 0.687216
+TGATAA 58.02244 0.974032 0.822416 0.293922
+TGATAC 54.968757 0.81966 0.907459 0.340671
+TGATAG 57.916647 0.984747 0.810442 0.287527
+TGATAT 56.612879 0.83856 0.793425 0.278519
+TGATCA 52.205375 1.003564 1.013033 0.401819
+TGATCC 50.280091 1.041615 1.172966 0.500638
+TGATCG 52.037103 0.993671 0.984273 0.38483
+TGATCT 51.343076 0.745456 0.881156 0.325967
+TGATGA 54.415659 0.856929 0.992764 0.38982
+TGATGC 50.702309 1.028802 1.290283 0.577594
+TGATGG 54.003774 0.859789 0.900222 0.336605
+TGATGT 52.647806 0.768377 0.896198 0.33435
+TGATTA 49.563175 0.886877 1.169513 0.498428
+TGATTC 45.967563 1.100985 1.346809 0.615962
+TGATTG 48.876766 0.795122 1.037644 0.416551
+TGATTT 46.8488 1.097567 1.190448 0.511871
+TGCAAA 65.055961 1.208358 1.008231 0.398966
+TGCAAC 61.093687 1.530094 1.174573 0.501667
+TGCAAG 65.390341 0.953707 1.042233 0.419317
+TGCAAT 64.163508 1.125292 1.310111 0.590959
+TGCACA 62.83994 0.856565 0.855618 0.3119
+TGCACC 60.599346 0.859902 0.872907 0.321401
+TGCACG 62.503559 0.711749 0.891153 0.331531
+TGCACT 62.138009 0.867305 0.908617 0.341324
+TGCAGA 66.101237 1.081162 0.958367 0.369737
+TGCAGC 62.811344 1.520354 1.187179 0.509764
+TGCAGG 65.855731 1.054161 1.004224 0.396589
+TGCAGT 64.997295 1.17369 1.614326 0.808318
+TGCATA 62.453271 1.02869 0.955229 0.367923
+TGCATC 59.180755 1.997649 1.30671 0.588659
+TGCATG 61.697114 1.769366 1.153148 0.488004
+TGCATT 60.554439 2.399682 1.559622 0.767581
+TGCCAA 66.456294 0.84334 0.828753 0.297326
+TGCCAC 64.147583 0.940011 0.798856 0.281383
+TGCCAG 67.066208 0.927459 0.860786 0.31473
+TGCCAT 66.4584 0.754811 0.96136 0.371471
+TGCCCA 64.1296 1.097974 0.769943 0.266246
+TGCCCC 63.035505 1.468057 0.721148 0.241342
+TGCCCG 63.823041 0.994874 0.785277 0.274239
+TGCCCT 63.440781 0.896107 0.788564 0.275963
+TGCCGA 66.545323 0.912267 0.864726 0.316894
+TGCCGC 64.178692 0.966071 0.800198 0.282092
+TGCCGG 65.928888 0.94029 0.859977 0.314286
+TGCCGT 65.003725 0.882392 1.294516 0.580439
+TGCCTA 63.106466 0.845562 0.748541 0.255222
+TGCCTC 60.142579 1.275431 0.798415 0.28115
+TGCCTG 61.927349 1.070832 0.976557 0.380314
+TGCCTT 60.676788 1.492931 1.288195 0.576193
+TGCGAA 68.824421 1.475168 0.989225 0.387738
+TGCGAC 63.586368 0.88538 0.953844 0.367123
+TGCGAG 68.372335 1.06567 0.99297 0.389942
+TGCGAT 66.509703 0.933804 1.330208 0.604609
+TGCGCA 64.259943 1.208707 0.875226 0.322683
+TGCGCC 61.980172 0.829015 0.793949 0.278795
+TGCGCG 63.958379 1.0935 0.923945 0.349997
+TGCGCT 63.989607 1.198626 0.894954 0.333654
+TGCGGA 64.323534 1.098606 0.961083 0.37131
+TGCGGC 59.4206 1.376062 1.279757 0.57054
+TGCGGG 63.513694 1.296885 1.105143 0.45785
+TGCGGT 62.519403 1.306801 1.400939 0.653467
+TGCGTA 55.18848 2.052865 1.330226 0.604621
+TGCGTC 49.703904 2.538581 1.750658 0.912845
+TGCGTG 54.226405 2.088548 1.437545 0.679247
+TGCGTT 51.205661 2.383733 1.726505 0.89402
+TGCTAA 62.495578 0.790136 0.746644 0.254253
+TGCTAC 59.052177 0.749063 0.802083 0.28309
+TGCTAG 62.304387 0.687431 0.95939 0.370329
+TGCTAT 60.978647 0.68036 0.776078 0.269434
+TGCTCA 57.793894 0.823517 0.884956 0.328079
+TGCTCC 55.695161 0.799031 0.878301 0.324385
+TGCTCG 57.697328 0.837227 0.854106 0.311074
+TGCTCT 56.912634 0.742983 0.838911 0.302809
+TGCTGA 56.12696 1.332041 1.0641 0.432583
+TGCTGC 51.448802 1.267072 1.374553 0.635093
+TGCTGG 56.233719 0.893451 0.94172 0.360146
+TGCTGT 54.500526 1.026631 1.136545 0.477502
+TGCTTA 51.455118 1.006247 1.17219 0.500141
+TGCTTC 46.536581 1.343824 1.445831 0.685128
+TGCTTG 50.729379 1.347856 1.128241 0.472278
+TGCTTT 47.785893 1.676269 1.377618 0.637218
+TGGAAA 72.63157 1.312843 1.48523 0.713322
+TGGAAC 67.0628 1.573399 1.370104 0.632013
+TGGAAG 72.73879 1.57522 1.514825 0.734749
+TGGAAT 71.022104 2.031019 1.777915 0.934247
+TGGACA 61.948642 1.274271 0.816136 0.290562
+TGGACC 58.112648 0.929644 0.803185 0.283674
+TGGACG 61.202101 1.233231 0.869316 0.31942
+TGGACT 60.710481 0.81102 0.918423 0.346864
+TGGAGA 70.895545 1.581261 1.354039 0.620929
+TGGAGC 65.756251 1.509622 1.289008 0.576738
+TGGAGG 69.631549 1.623394 1.401188 0.653642
+TGGAGT 68.412039 1.152952 1.699308 0.872978
+TGGATA 61.2344 1.514419 1.136173 0.477268
+TGGATC 57.245698 1.719811 1.279635 0.570459
+TGGATG 60.655895 1.393446 1.199463 0.517697
+TGGATT 58.67261 1.914502 1.380197 0.639009
+TGGCAA 70.489301 1.196132 1.239277 0.543686
+TGGCAC 67.630164 1.042204 1.160636 0.492764
+TGGCAG 70.440848 1.16468 1.224902 0.534253
+TGGCAT 69.738784 1.264403 1.386419 0.643335
+TGGCCA 64.671131 1.212516 0.915473 0.345194
+TGGCCC 62.732171 0.73464 0.804247 0.284236
+TGGCCG 64.423979 0.942945 0.882963 0.326971
+TGGCCT 64.129309 0.91778 0.933546 0.355467
+TGGCGA 70.019399 1.149407 1.157217 0.490589
+TGGCGC 66.37445 1.10973 1.140298 0.479869
+TGGCGG 68.389913 1.148086 1.258114 0.556129
+TGGCGT 66.918441 1.358467 1.639256 0.827114
+TGGCTA 64.838952 1.077641 1.062141 0.431389
+TGGCTC 62.179265 1.203623 1.169705 0.498551
+TGGCTG 63.848874 1.292837 1.257763 0.555896
+TGGCTT 62.966152 1.691504 1.465689 0.699291
+TGGGAA 72.502006 2.53849 1.541992 0.754603
+TGGGAC 64.782689 1.456709 1.058526 0.429188
+TGGGAG 70.872604 2.61176 1.59244 0.791936
+TGGGAT 68.845136 1.708223 1.510615 0.731688
+TGGGCA 63.982546 2.248341 1.351093 0.618904
+TGGGCC 60.553055 1.604129 1.072918 0.437971
+TGGGCG 63.468831 2.292794 1.326087 0.601801
+TGGGCT 62.866823 2.61176 1.28469 0.573843
+TGGGGA 67.584394 1.689705 1.218937 0.530355
+TGGGGC 62.817274 1.574164 1.036497 0.41586
+TGGGGG 66.259475 1.367634 1.168042 0.497488
+TGGGGT 65.727673 1.379433 1.160699 0.492804
+TGGGTA 59.705472 1.378369 0.971926 0.377612
+TGGGTC 54.31732 1.134929 1.118665 0.466278
+TGGGTG 58.882336 1.170724 1.030043 0.411982
+TGGGTT 56.052761 1.3835 1.242274 0.545659
+TGGTAA 58.188389 1.529138 0.965352 0.373787
+TGGTAC 54.132565 0.830314 0.971528 0.37738
+TGGTAG 57.648016 1.761638 0.972953 0.37821
+TGGTAT 56.328901 1.626169 0.907719 0.340818
+TGGTCA 50.952522 1.761717 1.174797 0.50181
+TGGTCC 48.349639 1.66249 1.1706 0.499124
+TGGTCG 50.455668 1.933518 1.164531 0.495247
+TGGTCT 49.483806 1.588861 1.062912 0.431858
+TGGTGA 54.51888 1.179311 0.96746 0.375012
+TGGTGC 50.526159 0.766302 1.053851 0.426348
+TGGTGG 53.780571 1.34557 0.92229 0.349057
+TGGTGT 52.511274 0.716199 0.868413 0.318922
+TGGTTA 48.439774 0.796718 1.026227 0.409695
+TGGTTC 44.948319 0.85373 1.124306 0.46981
+TGGTTG 47.697349 0.714097 0.940043 0.359184
+TGGTTT 45.81224 0.939632 1.008243 0.398972
+TGTAAA 62.920931 1.054833 0.876947 0.323635
+TGTAAC 59.351018 0.800575 0.813519 0.289166
+TGTAAG 63.393139 1.26776 1.018507 0.40508
+TGTAAT 62.211098 1.006046 0.980071 0.382368
+TGTACA 58.849742 1.480685 1.058086 0.42892
+TGTACC 56.731541 1.044328 0.837499 0.302045
+TGTACG 58.771842 1.44427 1.036673 0.415966
+TGTACT 58.271921 1.270305 0.889213 0.330449
+TGTAGA 62.746266 1.036903 1.059655 0.429875
+TGTAGC 59.558803 0.7611 0.822039 0.29372
+TGTAGG 62.17938 0.910268 0.932582 0.354916
+TGTAGT 61.347454 0.953878 1.076881 0.4404
+TGTATA 58.262747 0.746023 0.775627 0.2692
+TGTATC 55.500297 1.208828 0.801836 0.282959
+TGTATG 57.58245 0.7868 0.842092 0.304533
+TGTATT 56.296191 0.977149 1.012574 0.401546
+TGTCAA 60.519183 1.788987 1.35916 0.624455
+TGTCAC 58.628701 1.115043 1.103927 0.457095
+TGTCAG 60.172319 2.131656 1.506703 0.728848
+TGTCAT 60.649033 1.910119 1.369973 0.631922
+TGTCCA 56.204961 2.250006 1.450688 0.688583
+TGTCCC 55.018501 1.992801 1.372072 0.633374
+TGTCCG 56.365226 2.411128 1.363204 0.627244
+TGTCCT 55.832006 1.957685 1.42819 0.672627
+TGTCGA 59.977545 1.802165 1.417613 0.665169
+TGTCGC 58.024787 1.126699 1.176243 0.502737
+TGTCGG 59.065164 1.736576 1.460343 0.695469
+TGTCGT 58.434215 1.568843 1.456157 0.692481
+TGTCTA 56.394825 1.36104 1.16685 0.496727
+TGTCTC 54.443357 0.880893 0.858285 0.313359
+TGTCTG 55.708814 1.11527 1.057086 0.428312
+TGTCTT 54.29749 1.14433 1.134304 0.476091
+TGTGAA 60.671868 2.61176 1.339138 0.610708
+TGTGAC 55.152877 1.380841 0.878821 0.324673
+TGTGAG 58.618739 1.809447 1.260141 0.557473
+TGTGAT 58.642674 2.350721 1.35233 0.619754
+TGTGCA 55.220212 2.61176 1.405779 0.656857
+TGTGCC 52.78456 1.87823 1.150366 0.486238
+TGTGCG 54.665594 2.609916 1.38237 0.640518
+TGTGCT 54.546641 2.574911 1.274969 0.567341
+TGTGGA 58.268143 1.722555 1.189146 0.511032
+TGTGGC 54.725679 0.946548 1.05737 0.428485
+TGTGGG 57.3051 1.532343 1.079172 0.441806
+TGTGGT 56.820713 1.29085 1.092731 0.450158
+TGTGTA 51.76085 0.785075 0.806117 0.285228
+TGTGTC 46.91722 0.905841 0.920863 0.348247
+TGTGTG 50.766875 0.852429 0.792099 0.277821
+TGTGTT 48.21744 1.776582 0.847373 0.307402
+TGTTAA 54.493033 1.878293 1.150451 0.486292
+TGTTAC 51.350082 1.383916 1.01356 0.402133
+TGTTAG 54.158808 2.424562 1.216419 0.528713
+TGTTAT 52.942566 1.850571 1.017139 0.404265
+TGTTCA 48.209865 2.03477 1.229557 0.537302
+TGTTCC 46.267976 1.544403 1.23011 0.537665
+TGTTCG 47.710084 1.740635 1.194619 0.514564
+TGTTCT 47.261545 1.682313 1.038238 0.416908
+TGTTGA 50.393721 1.246241 1.142506 0.481263
+TGTTGC 47.379736 0.81577 1.0267 0.409978
+TGTTGG 50.239906 1.410226 0.946382 0.362823
+TGTTGT 49.364507 1.146609 0.821344 0.293348
+TGTTTA 46.033151 1.159837 1.019788 0.405845
+TGTTTC 42.854622 0.671901 0.880182 0.325427
+TGTTTG 45.504732 0.891808 0.77821 0.270545
+TGTTTT 43.88442 0.640877 0.717824 0.239675
+TTAAAA 64.017501 0.959431 0.830252 0.298133
+TTAAAC 59.268967 1.001382 0.872544 0.321201
+TTAAAG 63.881475 0.938216 0.840937 0.303907
+TTAAAT 62.579393 0.930906 1.002173 0.395375
+TTAACA 58.255335 0.767299 0.764805 0.263586
+TTAACC 55.867342 0.822649 0.828072 0.29696
+TTAACG 58.00915 0.797134 0.765284 0.263833
+TTAACT 57.466205 0.773633 0.704042 0.232805
+TTAAGA 64.504486 0.885849 0.861463 0.315101
+TTAAGC 60.120147 1.088865 1.023251 0.407914
+TTAAGG 63.641338 1.05247 0.834518 0.300434
+TTAAGT 62.605958 0.886912 1.08761 0.446997
+TTAATA 58.007227 0.942327 0.923832 0.349933
+TTAATC 54.825761 1.796022 1.133551 0.475617
+TTAATG 57.430965 1.279893 0.951921 0.366013
+TTAATT 56.045417 1.674163 1.160379 0.492601
+TTACAA 65.681836 0.981892 0.905581 0.339615
+TTACAC 63.399734 0.855803 0.779636 0.27129
+TTACAG 66.294487 1.231447 0.963677 0.372814
+TTACAT 65.505593 1.124164 0.981672 0.383305
+TTACCA 61.867945 1.174061 0.819751 0.292495
+TTACCC 59.828975 0.830343 0.722031 0.241785
+TTACCG 61.576011 1.07848 0.829632 0.297799
+TTACCT 61.031288 1.168849 0.793453 0.278533
+TTACGA 65.287214 1.20056 0.958035 0.369545
+TTACGC 62.383133 0.905874 0.80254 0.283332
+TTACGG 64.314587 1.154433 0.908568 0.341296
+TTACGT 63.169096 0.959399 1.196077 0.515506
+TTACTA 61.061825 1.055597 0.749019 0.255467
+TTACTC 58.681743 1.314235 0.756816 0.259466
+TTACTG 60.289673 0.922601 0.858377 0.31341
+TTACTT 58.912755 1.357088 1.056219 0.427786
+TTAGAA 66.907875 1.474987 1.049896 0.42395
+TTAGAC 60.98278 0.761362 0.831257 0.298674
+TTAGAG 66.602149 1.327851 0.962442 0.372098
+TTAGAT 64.474758 1.530235 1.045271 0.421152
+TTAGCA 62.259519 1.858585 0.986145 0.385928
+TTAGCC 58.80357 0.790321 0.80518 0.284731
+TTAGCG 62.12065 1.586816 0.957943 0.369492
+TTAGCT 61.427213 1.554268 0.955874 0.368296
+TTAGGA 64.56839 0.903099 0.948244 0.363895
+TTAGGC 59.755263 1.079793 1.091961 0.449682
+TTAGGG 63.632504 1.214478 0.886162 0.32875
+TTAGGT 62.614733 1.222653 1.033566 0.414097
+TTAGTA 55.821528 1.04739 1.031846 0.413064
+TTAGTC 50.778043 1.597105 1.218286 0.52993
+TTAGTG 55.168315 1.320565 1.037159 0.416258
+TTAGTT 52.446228 1.92349 1.230933 0.538204
+TTATAA 60.56946 1.283086 0.746184 0.254018
+TTATAC 56.768778 0.75874 0.722722 0.242132
+TTATAG 59.944255 1.222339 0.71941 0.24047
+TTATAT 58.698612 1.011282 0.714678 0.238101
+TTATCA 54.644283 0.870033 0.860861 0.314771
+TTATCC 52.712552 0.821009 0.98851 0.387318
+TTATCG 54.51816 0.854133 0.816738 0.290884
+TTATCT 53.779878 0.72826 0.693032 0.227366
+TTATGA 55.462858 0.927325 0.912576 0.343557
+TTATGC 51.318029 1.119205 1.237683 0.542637
+TTATGG 55.331111 0.843816 0.789239 0.276318
+TTATGT 53.63634 0.820328 0.964403 0.373236
+TTATTA 50.603917 1.022626 1.053308 0.426019
+TTATTC 46.226144 1.166086 1.2033 0.520183
+TTATTG 49.779865 0.806605 0.897231 0.334928
+TTATTT 47.259459 1.281515 1.119387 0.46673
+TTCAAA 63.789114 1.086692 0.994276 0.390711
+TTCAAC 59.409834 1.288738 0.92012 0.347826
+TTCAAG 64.213828 0.878779 0.969054 0.375939
+TTCAAT 62.994656 0.821823 1.151302 0.486832
+TTCACA 62.283507 0.978231 0.817183 0.291122
+TTCACC 60.268217 0.766987 0.8101 0.287345
+TTCACG 61.983073 0.947152 0.854018 0.311026
+TTCACT 61.619623 0.893791 0.852306 0.310091
+TTCAGA 65.496398 1.007966 1.038837 0.417269
+TTCAGC 62.486875 1.982184 1.060795 0.430569
+TTCAGG 65.128585 0.940055 0.997117 0.392387
+TTCAGT 64.488199 1.272064 1.386722 0.643546
+TTCATA 62.15867 1.268582 0.973478 0.378516
+TTCATC 58.717681 1.372391 1.068267 0.435126
+TTCATG 61.186274 1.494181 1.13584 0.477058
+TTCATT 59.825943 2.084849 1.245123 0.547538
+TTCCAA 66.160747 1.121393 1.180751 0.50563
+TTCCAC 63.804786 0.871447 0.864735 0.316898
+TTCCAG 67.221979 1.176728 1.138323 0.478623
+TTCCAT 66.229481 1.091771 1.173272 0.500833
+TTCCCA 63.872255 1.574007 1.077935 0.441046
+TTCCCC 62.299735 1.04508 0.893547 0.332868
+TTCCCG 63.727381 1.378282 1.165884 0.49611
+TTCCCT 63.349823 1.408421 1.032475 0.413442
+TTCCGA 66.395745 1.272081 1.147339 0.484321
+TTCCGC 63.736348 1.01305 0.874785 0.322439
+TTCCGG 65.996762 1.17261 1.19848 0.517061
+TTCCGT 64.776015 1.12354 1.527902 0.744284
+TTCCTA 62.876038 0.785474 0.835935 0.301199
+TTCCTC 60.430994 1.443417 0.886647 0.32902
+TTCCTG 61.854348 1.022647 1.052862 0.425748
+TTCCTT 60.630674 1.108866 1.229506 0.537268
+TTCGAA 67.817498 1.551929 1.159368 0.491957
+TTCGAC 62.872812 0.883094 0.868571 0.319009
+TTCGAG 67.015965 1.231763 1.090754 0.448937
+TTCGAT 65.67949 1.20738 1.080828 0.442823
+TTCGCA 64.236394 1.524544 0.989078 0.387651
+TTCGCC 61.80062 0.974972 0.721479 0.241508
+TTCGCG 64.004753 1.557444 1.002146 0.395359
+TTCGCT 63.777761 1.390896 0.982912 0.384032
+TTCGGA 63.964392 1.050425 1.049524 0.423725
+TTCGGC 58.597234 1.196896 1.123056 0.469027
+TTCGGG 63.095914 1.111145 1.043828 0.42028
+TTCGGT 61.899977 1.319611 1.249482 0.550415
+TTCGTA 53.909851 2.131886 1.234432 0.540501
+TTCGTC 48.390264 2.304921 1.480015 0.709569
+TTCGTG 53.394022 2.126352 1.291878 0.578666
+TTCGTT 50.064338 2.525795 1.519303 0.73801
+TTCTAA 62.344167 1.025564 0.935653 0.356671
+TTCTAC 59.017861 0.818491 0.765551 0.263971
+TTCTAG 62.484752 0.795298 0.979265 0.381896
+TTCTAT 60.871566 0.896479 0.765684 0.26404
+TTCTCA 58.414322 1.26299 0.757565 0.259851
+TTCTCC 58.003311 2.437927 0.831393 0.298748
+TTCTCG 58.508806 1.160688 0.78999 0.276712
+TTCTCT 57.535977 0.849678 0.735347 0.248504
+TTCTGA 55.868568 1.443582 0.905133 0.339362
+TTCTGC 50.972231 1.211532 1.193618 0.513917
+TTCTGG 56.181364 0.89208 0.824395 0.294984
+TTCTGT 54.223261 0.855544 0.928624 0.352659
+TTCTTA 51.033697 0.882598 0.979011 0.381748
+TTCTTC 45.729057 1.132193 1.183077 0.507124
+TTCTTG 50.533081 1.197865 0.92921 0.352993
+TTCTTT 47.204505 1.386592 1.054096 0.426497
+TTGAAA 69.138645 1.284194 1.375675 0.635871
+TTGAAC 63.808422 1.491825 1.253805 0.553274
+TTGAAG 69.153996 1.331971 1.437079 0.678916
+TTGAAT 67.558506 1.348202 1.665283 0.846891
+TTGACA 60.337071 1.050954 0.852363 0.310121
+TTGACC 57.427073 1.09389 0.840226 0.303521
+TTGACG 59.778821 0.983289 0.862644 0.31575
+TTGACT 59.549415 0.827481 0.85085 0.309297
+TTGAGA 67.419088 1.330027 1.236625 0.541941
+TTGAGC 62.360067 1.470857 1.218378 0.529991
+TTGAGG 66.516651 1.294267 1.234536 0.540568
+TTGAGT 65.071509 1.473618 1.551709 0.761747
+TTGATA 59.476939 1.335512 1.052821 0.425723
+TTGATC 55.701651 1.973601 1.177961 0.503839
+TTGATG 58.751382 1.268944 1.135489 0.476837
+TTGATT 56.872744 2.05467 1.228875 0.536855
+TTGCAA 68.813892 1.121593 1.318248 0.596474
+TTGCAC 65.855759 0.981785 1.127593 0.471871
+TTGCAG 69.136828 1.387608 1.434675 0.677213
+TTGCAT 68.286031 1.249661 1.442978 0.683101
+TTGCCA 64.090979 1.435288 1.188992 0.510933
+TTGCCC 62.161501 0.991854 0.960441 0.370938
+TTGCCG 63.743837 1.372385 1.240029 0.544181
+TTGCCT 63.597637 1.084216 1.069239 0.43572
+TTGCGA 68.449711 1.395773 1.284471 0.573696
+TTGCGC 64.633186 1.069072 1.048366 0.423024
+TTGCGG 67.053606 1.330175 1.332127 0.605918
+TTGCGT 65.393946 1.448796 1.694192 0.869039
+TTGCTA 63.44708 0.934176 1.082072 0.443588
+TTGCTC 60.535095 1.303373 1.202466 0.519642
+TTGCTG 62.194682 1.217169 1.278868 0.569946
+TTGCTT 61.213681 1.347004 1.468448 0.701267
+TTGGAA 68.210566 2.597527 1.539128 0.752502
+TTGGAC 60.970577 1.916494 0.923911 0.349978
+TTGGAG 66.812731 2.61176 1.476394 0.706966
+TTGGAT 65.461203 1.482892 1.494458 0.719981
+TTGGCA 62.427312 2.49338 1.291031 0.578097
+TTGGCC 58.697184 1.542855 0.971374 0.37729
+TTGGCG 61.825375 2.418397 1.264337 0.56026
+TTGGCT 61.320716 2.124328 1.117037 0.465261
+TTGGGA 63.004287 1.306584 1.336226 0.608717
+TTGGGC 56.683148 0.888462 1.089188 0.447971
+TTGGGG 62.182065 1.019355 1.098681 0.45384
+TTGGGT 61.441896 1.311118 1.101427 0.455542
+TTGGTA 55.336065 1.315064 0.979365 0.381955
+TTGGTC 49.181982 0.964777 1.146504 0.483792
+TTGGTG 54.174922 0.908105 0.962758 0.372281
+TTGGTT 51.171148 1.338245 1.178862 0.504417
+TTGTAA 55.864815 1.655061 1.025576 0.409305
+TTGTAC 52.041075 1.101456 0.865319 0.317219
+TTGTAG 55.429927 1.458717 0.92588 0.351097
+TTGTAT 54.105 1.185272 0.797151 0.280483
+TTGTCA 48.963644 1.812333 1.10504 0.457786
+TTGTCC 46.011286 1.07707 1.055612 0.427417
+TTGTCG 48.486564 1.756816 1.096486 0.452481
+TTGTCT 48.017649 1.403509 0.984951 0.385227
+TTGTGA 51.687306 0.973825 0.989407 0.387845
+TTGTGC 47.725503 0.802245 1.13977 0.479536
+TTGTGG 50.796912 0.900832 0.868647 0.319051
+TTGTGT 49.694676 0.786856 0.763309 0.262812
+TTGTTA 46.426374 0.869604 1.013016 0.401809
+TTGTTC 42.907485 0.803892 1.017452 0.404451
+TTGTTG 45.747636 0.675379 0.815655 0.290306
+TTGTTT 43.748221 0.683766 0.832086 0.299122
+TTTAAA 63.678188 1.12665 1.006872 0.398159
+TTTAAC 59.962468 0.815933 0.878932 0.324734
+TTTAAG 64.513898 1.15798 1.17114 0.499469
+TTTAAT 62.972943 1.020071 1.124616 0.470004
+TTTACA 60.729972 1.666651 1.157084 0.490504
+TTTACC 58.222763 1.015085 0.908937 0.341504
+TTTACG 60.230069 1.508289 1.079899 0.442252
+TTTACT 59.834393 1.270885 0.960743 0.371113
+TTTAGA 63.61937 0.917085 1.004051 0.396487
+TTTAGC 60.258464 0.737067 0.952688 0.366455
+TTTAGG 63.226678 0.998564 1.035144 0.415046
+TTTAGT 62.423664 0.989672 1.255312 0.554272
+TTTATA 59.139112 0.811998 0.825525 0.295591
+TTTATC 56.21837 1.232957 0.949659 0.364709
+TTTATG 58.64464 0.921962 0.961074 0.371305
+TTTATT 57.1849 1.025796 1.153373 0.488146
+TTTCAA 62.632349 1.718284 1.378019 0.637497
+TTTCAC 60.279833 1.36794 1.093802 0.45082
+TTTCAG 62.970146 2.285483 1.493341 0.719173
+TTTCAT 62.878157 1.487799 1.411338 0.660757
+TTTCCA 59.526608 2.518419 1.481545 0.710669
+TTTCCC 57.340317 1.86033 1.335494 0.608217
+TTTCCG 59.052112 2.149044 1.47081 0.702959
+TTTCCT 58.401202 1.795969 1.353658 0.620667
+TTTCGA 62.409631 1.922549 1.4051 0.656381
+TTTCGC 60.058578 1.148063 1.10536 0.457985
+TTTCGG 61.845861 1.823139 1.467042 0.70026
+TTTCGT 60.712843 1.652886 1.576577 0.780132
+TTTCTA 58.199028 1.177431 1.065528 0.433454
+TTTCTC 56.098343 0.760711 0.870695 0.32018
+TTTCTG 57.618893 1.15002 1.085 0.445389
+TTTCTT 56.128693 1.172183 1.148882 0.485298
+TTTGAA 61.176525 2.61176 1.422498 0.66861
+TTTGAC 55.455433 1.464068 0.9241 0.350085
+TTTGAG 60.373803 2.61176 1.280825 0.571255
+TTTGAT 58.897468 2.162015 1.246754 0.548614
+TTTGCA 56.678328 2.61176 1.40508 0.656367
+TTTGCC 54.149145 1.990281 1.139964 0.479658
+TTTGCG 56.301832 2.441214 1.297422 0.582394
+TTTGCT 55.783567 2.299389 1.22608 0.535025
+TTTGGA 58.480444 1.903079 1.204124 0.520717
+TTTGGC 55.020201 0.932819 1.032873 0.413681
+TTTGGG 58.059076 1.387405 1.079222 0.441836
+TTTGGT 57.488631 1.336497 1.097716 0.453242
+TTTGTA 51.784821 0.871775 0.828769 0.297335
+TTTGTC 46.961711 1.061592 0.955189 0.3679
+TTTGTG 51.010769 1.440859 0.814891 0.289898
+TTTGTT 48.764338 1.317266 0.875668 0.322927
+TTTTAA 55.772811 2.28337 1.210862 0.525094
+TTTTAC 52.710154 1.353592 1.003471 0.396144
+TTTTAG 55.777005 2.306786 1.292949 0.579385
+TTTTAT 54.295398 1.706486 1.151662 0.48706
+TTTTCA 50.031414 2.031283 1.184394 0.507972
+TTTTCC 48.005231 1.577849 1.147136 0.484192
+TTTTCG 50.153301 2.005011 1.122103 0.46843
+TTTTCT 49.231456 1.754684 0.984423 0.384918
+TTTTGA 51.491961 1.248582 1.117927 0.465817
+TTTTGC 48.155593 0.753259 1.016172 0.403688
+TTTTGG 51.38789 1.202755 0.920116 0.347824
+TTTTGT 50.350934 0.989782 0.823527 0.294518
+TTTTTA 47.066556 0.961782 0.939644 0.358955
+TTTTTC 43.394294 0.634005 0.813589 0.289203
+TTTTTG 46.614407 0.84865 0.731722 0.246669
+TTTTTT 44.935799 1.20688 0.689795 0.225775
diff --git a/src/builtin_models/r73.c.p2.006.ont.model b/src/builtin_models/r73.c.p2.006.ont.model
new file mode 100644
index 0000000..2fdd9fd
--- /dev/null
+++ b/src/builtin_models/r73.c.p2.006.ont.model
@@ -0,0 +1,4096 @@
+AAAAAA 64.629638 0.833362 0.737681 0.242484
+AAAAAC 62.527649 0.635756 0.807218 0.277567
+AAAAAG 64.378161 0.965655 0.749702 0.248435
+AAAAAT 63.900011 0.996134 0.813838 0.280988
+AAAACA 57.712252 0.863177 0.926866 0.341512
+AAAACC 56.667915 0.997764 0.886807 0.319613
+AAAACG 57.390684 0.821559 0.898262 0.325826
+AAAACT 57.587168 0.700376 0.790772 0.269127
+AAAAGA 65.334701 0.918043 0.784542 0.265953
+AAAAGC 62.692478 2.197355 1.094335 0.438133
+AAAAGG 64.772382 0.859744 0.746228 0.246711
+AAAAGT 65.211246 0.675945 0.880435 0.316175
+AAAATA 61.707307 0.887863 0.835005 0.292021
+AAAATC 61.128958 0.833639 0.96432 0.36242
+AAAATG 61.515471 0.91513 0.897617 0.325474
+AAAATT 62.233706 0.827353 1.085988 0.43313
+AAACAA 61.227845 1.109486 0.796701 0.272159
+AAACAC 60.764369 1.075868 0.760292 0.253718
+AAACAG 60.628639 1.187528 0.862943 0.306799
+AAACAT 61.242991 1.120791 0.91758 0.336392
+AAACCA 56.839198 0.925779 0.927692 0.341969
+AAACCC 56.171979 0.800513 0.829338 0.289054
+AAACCG 56.485169 0.850677 0.905366 0.329698
+AAACCT 56.611043 0.777709 0.797505 0.272572
+AAACGA 60.743847 1.142399 0.830512 0.289667
+AAACGC 60.57768 0.939168 0.764214 0.255684
+AAACGG 60.093877 1.121828 0.874435 0.312948
+AAACGT 60.471982 0.926031 0.940865 0.349278
+AAACTA 59.017705 0.768631 0.713684 0.230749
+AAACTC 58.553369 0.628513 0.733742 0.240545
+AAACTG 58.79133 0.890006 0.755154 0.25115
+AAACTT 59.054212 0.696561 0.7952 0.271391
+AAAGAA 63.849731 0.811106 0.855406 0.302788
+AAAGAC 62.281945 0.643199 0.771607 0.259403
+AAAGAG 63.262719 0.851689 0.849982 0.299913
+AAAGAT 63.743549 0.742303 0.851231 0.300574
+AAAGCA 58.310593 0.914487 1.153169 0.473936
+AAAGCC 57.557563 0.993855 1.115569 0.450946
+AAAGCG 58.093364 0.912947 1.17934 0.490162
+AAAGCT 58.481905 0.800453 1.012274 0.389787
+AAAGGA 63.158317 0.748579 0.835978 0.292532
+AAAGGC 62.289836 0.647803 0.853385 0.301716
+AAAGGG 62.642826 0.768296 0.756565 0.251855
+AAAGGT 63.512989 0.724034 0.816367 0.282299
+AAAGTA 60.910908 0.826169 0.89928 0.326379
+AAAGTC 59.718196 0.986372 1.065573 0.420974
+AAAGTG 60.676332 0.813983 0.951333 0.355123
+AAAGTT 61.105313 0.871817 1.09159 0.436486
+AAATAA 56.266002 1.061604 0.999122 0.382216
+AAATAC 55.074393 0.884661 0.96933 0.365248
+AAATAG 55.898827 1.110642 1.020208 0.394379
+AAATAT 55.851896 0.93262 0.957072 0.358342
+AAATCA 51.183088 1.228344 1.433741 0.657032
+AAATCC 49.913587 1.071079 1.334995 0.590337
+AAATCG 50.93312 1.297987 1.357141 0.605087
+AAATCT 50.735822 1.149204 1.254432 0.537714
+AAATGA 55.069175 0.964162 0.896449 0.32484
+AAATGC 53.709249 0.979285 1.174708 0.487277
+AAATGG 54.426783 0.985935 0.878401 0.315079
+AAATGT 54.491358 1.11885 0.948316 0.353435
+AAATTA 51.372848 1.267756 1.275046 0.551022
+AAATTC 49.587794 1.295414 1.552074 0.74003
+AAATTG 51.09986 1.234547 1.20541 0.506504
+AAATTT 50.92038 1.339019 1.36784 0.612257
+AACAAA 67.21605 0.748433 0.887871 0.320188
+AACAAC 65.111439 0.67762 0.969702 0.365459
+AACAAG 66.841771 0.710404 0.891156 0.321967
+AACAAT 66.867556 0.730814 0.95511 0.357241
+AACACA 63.384946 0.605926 0.755186 0.251166
+AACACC 62.360638 0.634065 0.746693 0.246941
+AACACG 63.026565 0.615941 0.745284 0.246243
+AACACT 63.468701 0.677938 0.783002 0.26517
+AACAGA 68.759744 0.945702 1.073139 0.425466
+AACAGC 67.63469 0.998575 1.076548 0.427495
+AACAGG 68.318479 0.821653 0.965711 0.363204
+AACAGT 68.719341 1.005806 1.188972 0.496179
+AACATA 66.683754 0.862294 0.936253 0.346713
+AACATC 65.92015 0.830123 1.112928 0.449347
+AACATG 66.329572 0.816643 1.059044 0.417111
+AACATT 66.876579 0.948413 1.312319 0.57536
+AACCAA 65.730495 1.582184 1.069834 0.423502
+AACCAC 65.299646 1.133794 0.981589 0.372199
+AACCAG 65.089588 1.466332 1.087701 0.434155
+AACCAT 65.49113 1.530861 1.099665 0.441338
+AACCCA 62.228052 1.187984 0.867292 0.309121
+AACCCC 61.447963 1.021787 0.802027 0.274893
+AACCCG 61.808863 1.150302 0.872767 0.312053
+AACCCT 62.017289 1.168292 0.879408 0.315621
+AACCGA 65.309225 1.504609 1.058897 0.417024
+AACCGC 65.323983 1.38235 0.961305 0.360722
+AACCGG 64.713244 1.450503 1.109249 0.44712
+AACCGT 65.143005 1.685159 1.205373 0.506481
+AACCTA 63.987689 1.18194 0.902385 0.328072
+AACCTC 63.211518 1.076393 0.901267 0.327462
+AACCTG 63.576666 1.060478 0.990883 0.377497
+AACCTT 63.471755 1.206512 1.158987 0.477527
+AACGAA 67.541185 1.164507 1.026899 0.398265
+AACGAC 66.332069 0.722831 0.767121 0.257144
+AACGAG 67.348508 1.065938 1.037508 0.404453
+AACGAT 67.739027 1.109146 1.042942 0.407635
+AACGCA 62.931746 0.726401 0.85607 0.303141
+AACGCC 62.175747 0.663528 0.705257 0.226674
+AACGCG 62.816747 0.733834 0.811401 0.279727
+AACGCT 63.214553 0.751798 0.826299 0.287466
+AACGGA 66.476958 1.003797 1.003818 0.384913
+AACGGC 65.411173 0.989171 1.107579 0.446111
+AACGGG 66.154205 0.982572 0.971615 0.366541
+AACGGT 66.389653 1.088578 1.166969 0.482469
+AACGTA 64.256383 0.825833 1.065798 0.421107
+AACGTC 62.85325 0.994721 1.180014 0.490582
+AACGTG 64.029895 0.855405 1.102937 0.443309
+AACGTT 64.253492 0.891087 1.23242 0.523623
+AACTAA 60.979063 0.715762 0.688772 0.218773
+AACTAC 59.917078 0.644733 0.654541 0.202668
+AACTAG 60.420433 0.748744 0.678191 0.213751
+AACTAT 60.567245 0.608921 0.679609 0.214422
+AACTCA 56.491076 0.709279 0.866777 0.308846
+AACTCC 55.528015 0.676664 0.812751 0.280425
+AACTCG 56.305383 0.679012 0.84088 0.295108
+AACTCT 56.16339 0.589541 0.726992 0.237233
+AACTGA 59.0689 0.832923 0.794937 0.271256
+AACTGC 57.144237 0.98715 0.963524 0.361971
+AACTGG 58.535332 0.837322 0.701194 0.224718
+AACTGT 58.230416 0.792276 0.797701 0.272672
+AACTTA 55.517588 0.93066 0.855738 0.302964
+AACTTC 53.492292 1.24871 1.101043 0.442168
+AACTTG 55.355535 0.991029 0.810331 0.279173
+AACTTT 54.854722 1.053578 0.941937 0.349876
+AAGAAA 75.512943 1.691203 1.611769 0.783132
+AAGAAC 73.30753 1.535125 1.582656 0.76201
+AAGAAG 75.320861 1.57197 1.573625 0.755497
+AAGAAT 75.491826 1.748319 1.81744 0.937715
+AAGACA 64.979201 0.920771 0.932743 0.344766
+AAGACC 63.67116 0.876536 1.003046 0.384469
+AAGACG 64.374105 0.884371 0.902239 0.327992
+AAGACT 65.142734 0.858995 1.036244 0.403714
+AAGAGA 74.742249 1.647182 1.551348 0.739511
+AAGAGC 72.901127 1.414054 1.530313 0.724521
+AAGAGG 74.105409 1.490561 1.541335 0.732362
+AAGAGT 74.308591 1.705028 1.868216 0.977285
+AAGATA 69.448285 1.070722 1.31874 0.579588
+AAGATC 68.855354 1.068836 1.4657 0.679123
+AAGATG 69.194548 1.160922 1.396163 0.631371
+AAGATT 70.487075 1.223105 1.650134 0.811259
+AAGCAA 70.543922 1.493244 1.36766 0.612136
+AAGCAC 69.737234 1.333391 1.271523 0.54874
+AAGCAG 69.66538 1.822932 1.222906 0.517572
+AAGCAT 70.624714 1.25909 1.464738 0.678454
+AAGCCA 64.315913 1.328986 0.995013 0.37986
+AAGCCC 63.703149 1.157701 0.914957 0.334951
+AAGCCG 64.044833 1.253978 0.996126 0.380498
+AAGCCT 64.165362 1.419188 1.023102 0.396058
+AAGCGA 70.23774 1.85424 1.259187 0.540774
+AAGCGC 69.232698 1.398604 1.264634 0.544287
+AAGCGG 69.206809 1.439697 1.22692 0.520122
+AAGCGT 69.346036 1.312814 1.390893 0.6278
+AAGCTA 67.238278 1.348163 1.246488 0.532614
+AAGCTC 66.470094 1.518372 1.310616 0.57424
+AAGCTG 66.603534 1.367186 1.288122 0.559521
+AAGCTT 67.290171 1.479413 1.529861 0.7242
+AAGGAA 69.263825 1.611231 1.297681 0.565761
+AAGGAC 66.690448 0.969646 1.016492 0.392226
+AAGGAG 68.222125 1.470405 1.283553 0.556546
+AAGGAT 68.660147 1.30364 1.319504 0.580092
+AAGGCA 61.165491 0.983624 1.055523 0.415033
+AAGGCC 60.136146 0.87995 1.021091 0.394891
+AAGGCG 60.882827 0.948361 1.042649 0.407463
+AAGGCT 61.854477 1.234688 1.114739 0.450444
+AAGGGA 67.630271 1.335193 1.153272 0.474
+AAGGGC 65.239262 0.95287 1.085774 0.433002
+AAGGGG 66.877234 1.260742 1.080828 0.430046
+AAGGGT 67.40701 1.023648 1.176443 0.488357
+AAGGTA 65.393107 0.928273 1.14085 0.466362
+AAGGTC 64.000475 0.995898 1.207051 0.507538
+AAGGTG 65.189844 0.912393 1.18318 0.492557
+AAGGTT 65.935786 0.986816 1.402501 0.635675
+AAGTAA 54.726961 1.239577 1.257706 0.539821
+AAGTAC 53.302715 0.914146 1.214804 0.512436
+AAGTAG 54.37638 1.263981 1.250094 0.534927
+AAGTAT 54.10595 0.952224 1.206889 0.507436
+AAGTCA 47.878 1.235132 1.600641 0.775035
+AAGTCC 46.652437 1.139454 1.498768 0.702234
+AAGTCG 47.500469 1.210942 1.592427 0.769077
+AAGTCT 47.627847 1.250155 1.470978 0.682794
+AAGTGA 53.496403 0.991462 1.1128 0.449269
+AAGTGC 52.181761 0.778964 1.337524 0.592015
+AAGTGG 52.670678 0.989216 1.149415 0.471624
+AAGTGT 52.705021 0.817471 1.092928 0.437288
+AAGTTA 48.744449 0.933292 1.268884 0.547033
+AAGTTC 47.304369 0.997226 1.568525 0.751827
+AAGTTG 48.309724 0.76828 1.209622 0.509161
+AAGTTT 48.433055 0.959181 1.427674 0.652866
+AATAAA 63.583988 1.371146 0.935778 0.346449
+AATAAC 62.519373 0.790013 0.871411 0.311326
+AATAAG 63.344233 1.197526 0.971361 0.366396
+AATAAT 63.662538 1.617317 1.043196 0.407784
+AATACA 58.552243 0.953433 0.875418 0.313476
+AATACC 57.95433 0.713511 0.734002 0.240672
+AATACG 58.409305 0.898079 0.847816 0.298767
+AATACT 58.757658 0.900381 0.842988 0.296219
+AATAGA 63.386021 1.423526 0.99082 0.377461
+AATAGC 62.923692 0.918136 0.985155 0.374229
+AATAGG 63.025899 1.458732 0.973988 0.367884
+AATAGT 64.038289 0.973265 1.112093 0.448841
+AATATA 60.9073 0.754573 0.850692 0.300289
+AATATC 60.115867 0.88016 0.968766 0.364929
+AATATG 60.696765 0.85196 0.931789 0.344237
+AATATT 60.953475 1.038406 1.096912 0.439681
+AATCAA 59.210599 1.596088 1.120971 0.454226
+AATCAC 59.085711 1.54823 1.043254 0.407818
+AATCAG 58.748601 1.63399 1.173448 0.486493
+AATCAT 59.318443 1.539958 1.12892 0.459066
+AATCCA 55.595252 1.21051 1.087531 0.434054
+AATCCC 54.787338 1.215377 0.985711 0.374546
+AATCCG 55.277782 1.217946 1.080403 0.429793
+AATCCT 55.230727 1.135542 1.02147 0.395111
+AATCGA 58.741141 1.529169 1.206938 0.507467
+AATCGC 58.866855 1.447798 1.016745 0.392373
+AATCGG 58.19883 1.509755 1.152605 0.473589
+AATCGT 58.591311 1.43153 1.325285 0.583908
+AATCTA 57.138526 1.235271 0.904191 0.329057
+AATCTC 56.846536 1.103863 0.929011 0.342699
+AATCTG 56.648536 1.246488 0.968511 0.364785
+AATCTT 57.139462 1.062694 1.072756 0.425238
+AATGAA 56.364503 1.170076 1.077326 0.427958
+AATGAC 54.117526 0.671105 0.838329 0.293767
+AATGAG 55.603332 1.128228 1.05585 0.415226
+AATGAT 55.52378 0.92518 0.964488 0.362515
+AATGCA 51.046707 0.799714 1.384616 0.623555
+AATGCC 50.116941 0.732095 1.194617 0.499717
+AATGCG 50.971418 0.848344 1.326478 0.584697
+AATGCT 51.114904 0.747998 1.112897 0.449328
+AATGGA 56.377796 1.162577 0.993656 0.379083
+AATGGC 55.707983 0.808327 0.84212 0.295762
+AATGGG 56.056428 0.990595 0.806926 0.277416
+AATGGT 56.68528 0.911602 0.904182 0.329052
+AATGTA 54.140017 0.720486 0.869569 0.310339
+AATGTC 53.295469 0.644081 0.961903 0.361059
+AATGTG 54.071172 0.662386 0.821105 0.28476
+AATGTT 54.398202 0.658547 0.964151 0.362325
+AATTAA 50.211685 0.907044 1.068972 0.42299
+AATTAC 49.464254 0.635073 0.962484 0.361386
+AATTAG 49.925709 0.83194 1.059617 0.41745
+AATTAT 49.867961 0.670005 0.919366 0.337375
+AATTCA 45.003992 0.750414 1.349778 0.60017
+AATTCC 44.110664 0.791522 1.228854 0.521352
+AATTCG 44.928048 0.799018 1.316554 0.578148
+AATTCT 44.77291 0.729116 1.171454 0.485254
+AATTGA 49.408393 0.838829 0.970827 0.366094
+AATTGC 48.740241 0.562983 0.838562 0.293889
+AATTGG 48.861256 0.692658 0.876008 0.313792
+AATTGT 48.947538 0.596198 0.833176 0.291062
+AATTTA 45.741246 0.708729 0.959452 0.359679
+AATTTC 44.35878 0.679256 1.038497 0.405031
+AATTTG 45.43577 0.650735 0.883753 0.317963
+AATTTT 45.175313 0.627321 0.819858 0.284112
+ACAAAA 65.606452 0.783475 0.876984 0.314317
+ACAAAC 62.265061 0.818981 1.051345 0.412571
+ACAAAG 64.863367 0.786013 0.856113 0.303164
+ACAAAT 64.448505 0.704043 1.001719 0.383707
+ACAACA 59.008674 0.826378 1.00707 0.386786
+ACAACC 57.485648 0.749089 0.947323 0.352881
+ACAACG 58.657791 0.797737 0.996599 0.380769
+ACAACT 58.724058 0.62973 0.913371 0.334081
+ACAAGA 67.210177 0.880201 0.920287 0.337882
+ACAAGC 65.324007 1.084779 1.11663 0.45159
+ACAAGG 66.325505 0.803668 0.901546 0.327614
+ACAAGT 66.657647 0.89094 1.09781 0.440221
+ACAATA 63.338332 0.841587 0.997597 0.381341
+ACAATC 62.243211 1.026261 1.154568 0.474799
+ACAATG 63.107059 0.805526 1.105246 0.444702
+ACAATT 63.605363 0.929917 1.314468 0.576774
+ACACAA 67.463781 1.198492 0.905663 0.329861
+ACACAC 66.49662 0.858309 0.81671 0.282476
+ACACAG 66.914503 1.183968 0.871167 0.311195
+ACACAT 67.557315 1.127597 0.966499 0.363649
+ACACCA 63.426217 1.179853 0.78787 0.267647
+ACACCC 62.244811 0.975799 0.723583 0.235566
+ACACCG 62.871053 1.032874 0.782672 0.265003
+ACACCT 63.26159 1.125343 0.80927 0.278625
+ACACGA 66.950069 1.299564 0.882741 0.317417
+ACACGC 66.130348 0.811013 0.851978 0.30097
+ACACGG 66.281663 1.097627 0.885162 0.318724
+ACACGT 66.523593 0.975117 1.008973 0.387883
+ACACTA 64.914811 0.784326 0.799863 0.273782
+ACACTC 63.962724 1.086185 0.856868 0.303565
+ACACTG 64.391774 0.762076 0.874327 0.31289
+ACACTT 64.712213 0.766521 1.156445 0.475958
+ACAGAA 65.923203 0.973038 0.933084 0.344954
+ACAGAC 62.878625 0.974511 0.958643 0.359225
+ACAGAG 65.118118 0.956724 1.016503 0.392232
+ACAGAT 64.922551 1.019372 1.033241 0.40196
+ACAGCA 60.085565 1.308691 1.301088 0.56799
+ACAGCC 58.621476 1.036647 1.141125 0.466531
+ACAGCG 59.795248 1.159682 1.21325 0.511454
+ACAGCT 60.138824 1.161567 1.211505 0.51035
+ACAGGA 65.730283 0.876086 0.918636 0.336973
+ACAGGC 63.980905 1.085956 1.093996 0.437929
+ACAGGG 65.409831 0.998795 0.892225 0.322547
+ACAGGT 65.434593 0.758241 0.995343 0.380049
+ACAGTA 62.616618 1.277446 1.201116 0.5038
+ACAGTC 60.918426 1.95622 1.505881 0.70724
+ACAGTG 62.472848 1.630107 1.241485 0.529411
+ACAGTT 62.507396 1.597809 1.439845 0.661233
+ACATAA 60.551223 0.91438 0.909903 0.33218
+ACATAC 58.825754 1.115697 0.935884 0.346508
+ACATAG 60.270333 1.032241 0.94731 0.352873
+ACATAT 59.757903 0.844206 0.89472 0.3239
+ACATCA 55.015611 1.113242 1.349024 0.599667
+ACATCC 53.66801 1.050685 1.270343 0.547977
+ACATCG 54.864355 1.183313 1.296942 0.565277
+ACATCT 54.63819 1.079802 1.217966 0.514438
+ACATGA 59.044261 1.386217 1.103264 0.443506
+ACATGC 56.558727 1.511847 1.365615 0.610763
+ACATGG 58.179038 1.329903 1.031509 0.40095
+ACATGT 57.717339 1.272101 1.133359 0.461777
+ACATTA 54.464746 1.606896 1.445829 0.665359
+ACATTC 52.258722 2.086085 1.787394 0.914558
+ACATTG 54.198362 1.674571 1.378374 0.619343
+ACATTT 53.762605 2.146933 1.48552 0.692945
+ACCAAA 68.108064 0.755575 0.986797 0.375165
+ACCAAC 65.283145 1.111551 1.103908 0.443895
+ACCAAG 67.623424 0.753266 0.958335 0.359051
+ACCAAT 67.408392 0.814456 1.151294 0.472781
+ACCACA 64.236096 0.748058 0.864998 0.307895
+ACCACC 62.858879 0.721336 0.832106 0.290501
+ACCACG 63.882615 0.727826 0.841728 0.295555
+ACCACT 64.353079 0.816275 0.890889 0.321822
+ACCAGA 70.702533 0.844104 1.031948 0.401206
+ACCAGC 69.204618 0.783808 1.075343 0.426777
+ACCAGG 69.95608 0.769631 0.947258 0.352844
+ACCAGT 70.286044 0.937859 1.305156 0.570656
+ACCATA 68.144959 0.725782 1.032676 0.40163
+ACCATC 67.174008 0.891372 1.1584 0.477165
+ACCATG 67.905199 0.769017 1.224363 0.518497
+ACCATT 68.336037 0.877142 1.406726 0.63855
+ACCCAA 69.462241 1.134018 1.017615 0.392876
+ACCCAC 68.177624 0.932331 0.8604 0.305444
+ACCCAG 68.956074 1.314051 0.983964 0.373551
+ACCCAT 69.330666 1.103912 1.008357 0.387527
+ACCCCA 65.961506 0.949446 0.759829 0.253486
+ACCCCC 65.147457 0.715298 0.650925 0.200991
+ACCCCG 65.743373 0.935895 0.743071 0.245147
+ACCCCT 65.797313 0.923816 0.796724 0.272171
+ACCCGA 69.518902 1.33453 0.990131 0.377068
+ACCCGC 68.500284 1.063854 0.924582 0.340251
+ACCCGG 68.674553 1.299205 1.014891 0.3913
+ACCCGT 68.997523 1.119298 1.145668 0.46932
+ACCCTA 67.446292 0.978558 0.884753 0.318503
+ACCCTC 66.572719 0.835701 0.906049 0.330072
+ACCCTG 66.976459 0.967342 1.000791 0.383174
+ACCCTT 67.07432 1.050318 1.254018 0.537448
+ACCGAA 69.973547 0.924865 0.853731 0.3019
+ACCGAC 67.890542 0.74501 0.926422 0.341267
+ACCGAG 69.6135 0.848265 0.903886 0.328891
+ACCGAT 69.476098 0.790669 0.958947 0.359396
+ACCGCA 64.782556 0.674335 0.846489 0.298066
+ACCGCC 63.741309 0.649567 0.751492 0.249326
+ACCGCG 64.721496 0.717023 0.843995 0.29675
+ACCGCT 64.986111 0.702334 0.859605 0.30502
+ACCGGA 68.9602 0.948774 0.995149 0.379938
+ACCGGC 67.663019 0.875622 1.144434 0.468561
+ACCGGG 68.632491 0.872009 1.057968 0.416476
+ACCGGT 68.805265 0.897614 1.299144 0.566717
+ACCGTA 65.836862 1.290336 1.258672 0.540442
+ACCGTC 63.789747 1.983554 1.537854 0.729883
+ACCGTG 65.661677 1.325543 1.307572 0.572241
+ACCGTT 65.644281 1.573725 1.534682 0.727626
+ACCTAA 63.564051 0.828535 0.745658 0.246428
+ACCTAC 61.807419 0.858713 0.710419 0.229167
+ACCTAG 64.534011 1.215628 0.932965 0.344888
+ACCTAT 62.888046 0.775519 0.755239 0.251193
+ACCTCA 58.896552 0.827285 0.925853 0.340952
+ACCTCC 57.779144 0.710242 0.862915 0.306784
+ACCTCG 58.696168 0.808237 0.908205 0.331251
+ACCTCT 58.44452 0.688015 0.817671 0.282975
+ACCTGA 61.191848 1.125194 0.956204 0.357855
+ACCTGC 58.497596 1.544306 1.243878 0.530943
+ACCTGG 60.73214 1.026371 0.830304 0.289558
+ACCTGT 59.965875 1.167836 0.98723 0.375412
+ACCTTA 57.171331 1.411088 1.200645 0.503504
+ACCTTC 54.568093 2.033897 1.499509 0.702756
+ACCTTG 57.27555 1.310803 1.02431 0.39676
+ACCTTT 56.13918 1.634176 1.2704 0.548014
+ACGAAA 73.936588 1.355146 1.310905 0.574431
+ACGAAC 71.148221 0.920909 1.35965 0.606766
+ACGAAG 73.47093 1.344977 1.261924 0.542538
+ACGAAT 73.405449 1.264018 1.538853 0.730595
+ACGACA 63.830229 0.831983 0.779195 0.263239
+ACGACC 62.654378 0.776732 0.9377 0.347517
+ACGACG 63.629205 0.901818 0.801157 0.274446
+ACGACT 64.02519 0.746957 0.90059 0.327093
+ACGAGA 73.104869 1.338888 1.369699 0.613505
+ACGAGC 70.850475 0.971743 1.276785 0.55215
+ACGAGG 72.361426 1.260379 1.253507 0.537119
+ACGAGT 72.722142 1.159671 1.571261 0.753795
+ACGATA 67.783644 1.248516 1.191957 0.498048
+ACGATC 66.676985 1.634245 1.342176 0.595107
+ACGATG 67.509216 1.260668 1.26462 0.544278
+ACGATT 68.690303 1.405339 1.497151 0.701099
+ACGCAA 72.45157 1.567351 1.346816 0.598195
+ACGCAC 71.145142 1.475091 1.289839 0.56064
+ACGCAG 71.945989 1.51782 1.251137 0.535596
+ACGCAT 72.019723 1.576076 1.400872 0.634568
+ACGCCA 67.032087 1.189262 0.809893 0.278947
+ACGCCC 66.150133 0.888641 0.792716 0.27012
+ACGCCG 66.698928 1.138662 0.801363 0.274552
+ACGCCT 66.973026 0.947139 0.868641 0.309843
+ACGCGA 72.269658 1.613807 1.238213 0.527319
+ACGCGC 70.66166 1.493856 1.240916 0.529047
+ACGCGG 71.207307 1.330552 1.25355 0.537147
+ACGCGT 70.850102 1.569251 1.533796 0.726996
+ACGCTA 69.19215 1.318875 1.141316 0.466648
+ACGCTC 68.308779 1.070911 1.200164 0.503201
+ACGCTG 68.599046 1.240364 1.250487 0.535179
+ACGCTT 69.123043 1.323703 1.519086 0.716562
+ACGGAA 64.146329 1.142425 1.109752 0.447424
+ACGGAC 60.15718 0.931573 1.132434 0.461211
+ACGGAG 63.16318 1.195943 1.105019 0.444565
+ACGGAT 62.984309 1.003399 1.208633 0.508537
+ACGGCA 56.788146 1.193185 1.521966 0.718601
+ACGGCC 55.587302 1.307035 1.507403 0.708312
+ACGGCG 56.504304 1.27084 1.515893 0.714305
+ACGGCT 57.114102 1.232629 1.427244 0.652571
+ACGGGA 61.923509 1.295227 1.204187 0.505733
+ACGGGC 58.59088 1.506228 1.383787 0.622995
+ACGGGG 61.039774 1.202884 1.174737 0.487294
+ACGGGT 61.510669 1.199497 1.255639 0.53849
+ACGGTA 58.636067 1.660518 1.496357 0.700541
+ACGGTC 56.48405 2.197355 1.735855 0.875288
+ACGGTG 58.65652 1.757458 1.377641 0.618849
+ACGGTT 58.818427 1.993324 1.618009 0.787684
+ACGTAA 50.020123 1.843566 1.88204 0.988152
+ACGTAC 48.342373 1.45093 1.775787 0.905663
+ACGTAG 49.345516 1.62393 1.722868 0.865483
+ACGTAT 49.165437 1.478965 1.659533 0.8182
+ACGTCA 43.167994 1.733056 2.08281 1.150417
+ACGTCC 41.996145 1.616319 2.085708 1.152819
+ACGTCG 42.885762 1.605345 2.157591 1.212926
+ACGTCT 42.846016 1.515392 1.993206 1.076983
+ACGTGA 48.489479 1.324343 1.697677 0.84657
+ACGTGC 46.731119 1.138279 1.620745 0.789683
+ACGTGG 47.437521 1.298168 1.66275 0.820581
+ACGTGT 47.414055 1.133201 1.587811 0.765735
+ACGTTA 43.831882 1.174202 1.754329 0.889298
+ACGTTC 42.43328 1.426652 1.826976 0.945104
+ACGTTG 43.629417 1.20358 1.659327 0.818048
+ACGTTT 43.480145 1.554656 1.711731 0.857105
+ACTAAA 67.243618 1.034284 0.907185 0.330693
+ACTAAC 65.329906 0.761639 0.861385 0.305968
+ACTAAG 67.281333 1.134151 0.887066 0.319753
+ACTAAT 67.069481 0.938154 0.989981 0.376982
+ACTACA 61.743286 0.86444 0.705827 0.226949
+ACTACC 60.896268 0.780366 0.643228 0.197437
+ACTACG 61.476608 0.80905 0.657068 0.203843
+ACTACT 61.889255 0.795396 0.693278 0.220923
+ACTAGA 67.73695 1.134009 1.030283 0.400235
+ACTAGC 65.823726 1.088549 0.981334 0.372054
+ACTAGG 67.43758 0.860034 0.961334 0.360738
+ACTAGT 67.002585 1.139282 1.015405 0.391597
+ACTATA 63.631321 0.751244 0.806557 0.277225
+ACTATC 62.820602 0.665385 0.90638 0.330253
+ACTATG 63.460502 0.758832 0.880427 0.31617
+ACTATT 63.875762 0.827542 1.185647 0.494098
+ACTCAA 64.293486 1.622985 0.928689 0.34252
+ACTCAC 63.806934 1.343212 0.874772 0.313129
+ACTCAG 63.744311 1.64567 0.980232 0.371428
+ACTCAT 64.150417 1.556864 1.01868 0.393493
+ACTCCA 60.187496 1.143524 0.872468 0.311893
+ACTCCC 59.287809 1.043081 0.827547 0.288118
+ACTCCG 59.920794 1.110813 0.864305 0.307526
+ACTCCT 60.139683 1.092695 0.886211 0.319291
+ACTCGA 63.947888 1.573265 0.95452 0.35691
+ACTCGC 63.363301 1.560459 0.886137 0.319251
+ACTCGG 63.219149 1.667137 1.029053 0.399519
+ACTCGT 63.528839 1.462258 1.108734 0.446808
+ACTCTA 61.891632 1.085063 0.808457 0.278206
+ACTCTC 60.743667 1.00241 0.857294 0.303791
+ACTCTG 61.335351 1.043489 0.868073 0.309539
+ACTCTT 61.272216 1.085589 1.08997 0.435515
+ACTGAA 56.623132 1.05777 1.006055 0.386201
+ACTGAC 53.641391 0.87075 1.060562 0.418008
+ACTGAG 55.923489 0.995724 1.067086 0.421871
+ACTGAT 55.401804 0.86598 1.023763 0.396442
+ACTGCA 50.848097 0.922979 1.474768 0.685435
+ACTGCC 49.656056 1.005011 1.365891 0.610948
+ACTGCG 50.618369 0.896229 1.428034 0.653113
+ACTGCT 50.799876 0.93688 1.303883 0.569821
+ACTGGA 57.031425 0.979974 0.894831 0.32396
+ACTGGC 56.04872 0.627241 0.870225 0.310691
+ACTGGG 56.59485 0.792692 0.772955 0.260083
+ACTGGT 57.109019 0.772266 0.796766 0.272193
+ACTGTA 54.350075 0.735743 0.932805 0.3448
+ACTGTC 53.138226 0.878892 1.149368 0.471595
+ACTGTG 54.128386 0.665944 0.86198 0.306286
+ACTGTT 54.559083 0.658562 1.055113 0.414791
+ACTTAA 50.657351 0.979631 1.128717 0.458942
+ACTTAC 49.672176 0.815467 1.038347 0.404943
+ACTTAG 50.292078 0.921836 1.079702 0.429375
+ACTTAT 50.327659 0.816638 0.986421 0.374951
+ACTTCA 44.676821 0.965842 1.511357 0.711101
+ACTTCC 43.844937 1.139356 1.557962 0.744245
+ACTTCG 44.525677 0.94507 1.503863 0.705819
+ACTTCT 44.359891 0.900328 1.299453 0.56692
+ACTTGA 49.581795 0.881086 0.98216 0.372524
+ACTTGC 48.687937 0.553282 0.933639 0.345262
+ACTTGG 49.156662 0.860384 1.005122 0.385664
+ACTTGT 49.160719 0.746624 0.907357 0.330787
+ACTTTA 45.359161 0.780213 1.055205 0.414845
+ACTTTC 43.72847 0.647491 1.073266 0.425541
+ACTTTG 45.058789 0.72096 0.9957 0.380254
+ACTTTT 44.728287 0.638283 0.91918 0.337273
+AGAAAA 68.720407 1.307125 1.092392 0.436967
+AGAAAC 66.800354 1.646547 1.416778 0.645407
+AGAAAG 68.213245 1.269725 1.095986 0.439125
+AGAAAT 68.407221 1.406045 1.38803 0.625862
+AGAACA 60.604689 1.68652 1.240686 0.5289
+AGAACC 59.644607 1.635763 1.381371 0.621364
+AGAACG 60.317296 1.661435 1.243339 0.530597
+AGAACT 61.056975 1.600415 1.254231 0.537585
+AGAAGA 69.400519 1.429582 1.150731 0.472434
+AGAAGC 68.985404 1.871938 1.36602 0.611035
+AGAAGG 68.763604 1.543218 1.161587 0.479135
+AGAAGT 69.307689 1.709286 1.45031 0.668455
+AGAATA 65.173283 1.882857 1.395342 0.630815
+AGAATC 64.451365 1.898628 1.44564 0.665228
+AGAATG 64.788548 1.896319 1.397529 0.632298
+AGAATT 66.1659 1.908749 1.640054 0.803837
+AGACAA 63.222336 0.757302 0.752 0.249579
+AGACAC 63.220328 0.690036 0.771776 0.259488
+AGACAG 62.929991 0.835895 0.784177 0.265767
+AGACAT 63.49722 0.790903 0.792439 0.269979
+AGACCA 58.401912 0.777327 0.849247 0.299524
+AGACCC 57.604812 0.708156 0.834477 0.291744
+AGACCG 58.086911 0.725399 0.824138 0.286339
+AGACCT 58.254511 0.70049 0.785005 0.266188
+AGACGA 62.977552 0.93171 0.780844 0.264075
+AGACGC 62.426925 0.66633 0.774686 0.260957
+AGACGG 62.080596 0.796885 0.767597 0.257384
+AGACGT 62.612711 0.696801 0.882251 0.317153
+AGACTA 60.681597 0.676815 0.748039 0.247609
+AGACTC 60.034597 0.770044 0.861653 0.306111
+AGACTG 60.186037 0.677997 0.772891 0.260051
+AGACTT 60.659876 0.865896 1.07376 0.425835
+AGAGAA 67.676095 1.410872 1.193718 0.499153
+AGAGAC 66.171919 1.356678 1.243392 0.530631
+AGAGAG 67.125194 1.52344 1.267706 0.546271
+AGAGAT 67.36854 1.332752 1.192788 0.498569
+AGAGCA 61.099029 1.457481 1.419605 0.647339
+AGAGCC 59.884314 1.25237 1.277411 0.552556
+AGAGCG 60.857659 1.436863 1.431996 0.655833
+AGAGCT 61.327601 1.33739 1.358121 0.605743
+AGAGGA 66.505207 1.188696 1.106825 0.445655
+AGAGGC 65.829004 1.391308 1.277836 0.552832
+AGAGGG 66.397932 1.263076 1.082946 0.431311
+AGAGGT 67.080449 1.072496 1.187302 0.495134
+AGAGTA 64.058711 1.648176 1.381698 0.621585
+AGAGTC 63.116681 1.670403 1.544952 0.734942
+AGAGTG 63.785944 1.40219 1.371774 0.6149
+AGAGTT 64.442312 1.576586 1.551241 0.739434
+AGATAA 57.45954 1.206071 1.188169 0.495676
+AGATAC 56.001848 0.993219 1.147772 0.470613
+AGATAG 56.900303 1.231223 1.194342 0.499544
+AGATAT 56.98889 1.110835 1.188887 0.496125
+AGATCA 51.634388 1.288019 1.551823 0.739851
+AGATCC 50.306655 1.249521 1.504372 0.706177
+AGATCG 51.253543 1.297732 1.563488 0.748208
+AGATCT 51.478705 1.249718 1.519762 0.717041
+AGATGA 56.373789 1.320068 1.220242 0.515881
+AGATGC 55.162816 1.465097 1.524634 0.720492
+AGATGG 55.506172 1.292049 1.162625 0.479778
+AGATGT 55.881532 1.345339 1.34551 0.597325
+AGATTA 52.368957 1.538932 1.651134 0.811996
+AGATTC 50.510515 1.697213 1.973213 1.060819
+AGATTG 51.799781 1.501751 1.630954 0.797155
+AGATTT 52.001173 1.726165 1.839736 0.955023
+AGCAAA 68.045176 1.159894 1.069979 0.423588
+AGCAAC 65.922826 1.532768 1.239588 0.528198
+AGCAAG 67.676282 1.154238 1.03605 0.4036
+AGCAAT 67.55715 1.298114 1.216476 0.513495
+AGCACA 63.815815 1.163229 1.029995 0.400068
+AGCACC 62.845748 1.401471 1.041234 0.406634
+AGCACG 63.398943 1.086984 1.020223 0.394388
+AGCACT 64.096535 1.373787 1.083492 0.431637
+AGCAGA 69.806756 0.977529 1.034948 0.402957
+AGCAGC 68.978538 1.5834 1.189269 0.496365
+AGCAGG 69.106113 0.998267 1.011963 0.389608
+AGCAGT 69.756446 1.179048 1.34684 0.598211
+AGCATA 67.037232 1.421295 1.109627 0.447349
+AGCATC 66.601324 1.444713 1.278568 0.553307
+AGCATG 66.874504 1.486204 1.26258 0.542962
+AGCATT 67.515339 1.38658 1.618515 0.788054
+AGCCAA 66.488008 0.8225 0.789365 0.268409
+AGCCAC 65.902224 0.599087 0.752016 0.249587
+AGCCAG 66.009222 0.746155 0.781853 0.264587
+AGCCAT 66.476101 0.841392 0.846012 0.297814
+AGCCCA 63.312155 0.692306 0.7626 0.254874
+AGCCCC 62.727334 0.821757 0.737942 0.242613
+AGCCCG 63.06774 0.721535 0.783536 0.265442
+AGCCCT 63.288705 0.808541 0.776092 0.261668
+AGCCGA 66.265624 0.840395 0.724799 0.23616
+AGCCGC 65.991954 0.680718 0.745165 0.246183
+AGCCGG 65.502518 0.742365 0.784629 0.265997
+AGCCGT 66.144442 0.74601 0.999118 0.382213
+AGCCTA 64.848526 0.667847 0.769613 0.258398
+AGCCTC 64.274953 0.814434 0.855232 0.302696
+AGCCTG 64.372727 0.658853 0.868019 0.30951
+AGCCTT 64.755357 0.772363 1.114508 0.450304
+AGCGAA 69.100667 0.96097 0.957372 0.35851
+AGCGAC 67.745264 1.237196 1.029808 0.399959
+AGCGAG 68.738261 1.155899 1.004218 0.385143
+AGCGAT 69.201737 1.093323 1.092994 0.437328
+AGCGCA 64.052042 1.055016 1.086522 0.43345
+AGCGCC 63.078592 1.035599 1.00759 0.387085
+AGCGCG 63.874959 1.118075 1.083843 0.431848
+AGCGCT 64.201478 0.997595 1.0151 0.391421
+AGCGGA 67.558144 0.970196 1.026095 0.397797
+AGCGGC 66.874562 1.505322 1.303815 0.569776
+AGCGGG 67.346102 1.025979 1.104733 0.444393
+AGCGGT 67.745187 1.115625 1.361688 0.608131
+AGCGTA 64.644304 1.458393 1.311896 0.575082
+AGCGTC 63.586495 1.99992 1.602894 0.776672
+AGCGTG 64.515296 1.385528 1.397332 0.632165
+AGCGTT 64.790772 1.686121 1.570128 0.752979
+AGCTAA 61.955841 1.155499 0.962443 0.361362
+AGCTAC 60.489633 1.078039 0.893583 0.323283
+AGCTAG 62.021136 1.102285 0.89603 0.324612
+AGCTAT 61.442856 1.05829 0.911441 0.333022
+AGCTCA 57.179585 1.333109 1.197054 0.501246
+AGCTCC 55.817694 1.200983 1.165513 0.481567
+AGCTCG 56.924506 1.405204 1.15854 0.477251
+AGCTCT 56.787389 1.310602 1.11729 0.451991
+AGCTGA 60.222748 1.43702 1.090863 0.43605
+AGCTGC 58.176415 1.719034 1.345135 0.597076
+AGCTGG 59.708357 1.349364 0.992923 0.378664
+AGCTGT 59.16067 1.496641 1.149361 0.471591
+AGCTTA 56.243202 1.860955 1.375326 0.61729
+AGCTTC 54.429863 2.197355 1.670497 0.826322
+AGCTTG 56.204553 2.197355 1.270164 0.547861
+AGCTTT 55.66674 2.135947 1.432107 0.65591
+AGGAAA 81.322429 2.123275 2.03773 1.11327
+AGGAAC 79.095876 1.63253 2.013967 1.093853
+AGGAAG 80.8257 1.983286 1.996775 1.079877
+AGGAAT 81.249316 2.044766 2.227029 1.271949
+AGGACA 69.154085 1.072301 1.249228 0.534372
+AGGACC 67.218132 1.937241 1.304906 0.570492
+AGGACG 68.548757 1.176539 1.257045 0.539395
+AGGACT 69.539846 1.246616 1.398056 0.632656
+AGGAGA 79.95249 2.159051 1.929118 1.02546
+AGGAGC 78.536141 1.570365 1.908669 1.009199
+AGGAGG 79.381275 1.960323 1.905538 1.006716
+AGGAGT 79.828339 1.907838 2.192993 1.242901
+AGGATA 74.633585 1.29201 1.680587 0.83382
+AGGATC 73.977238 1.33836 1.914147 1.013546
+AGGATG 74.277979 1.22142 1.792882 0.918773
+AGGATT 76.021468 1.396798 1.997921 1.080807
+AGGCAA 75.328794 1.776738 1.721744 0.864637
+AGGCAC 74.520012 1.821104 1.645757 0.808033
+AGGCAG 74.844158 1.756675 1.632166 0.798045
+AGGCAT 75.17407 1.843132 1.740726 0.878974
+AGGCCA 69.124217 1.087489 1.088434 0.434594
+AGGCCC 67.979908 1.166498 1.109685 0.447384
+AGGCCG 68.701175 1.176718 1.062864 0.41937
+AGGCCT 68.523714 1.362989 1.220447 0.516011
+AGGCGA 75.034539 1.81927 1.666773 0.82356
+AGGCGC 74.036757 1.820373 1.671835 0.827315
+AGGCGG 73.999378 1.72826 1.619236 0.788581
+AGGCGT 73.705909 1.874066 1.871774 0.980079
+AGGCTA 71.677544 1.690059 1.52079 0.717769
+AGGCTC 71.478473 1.681206 1.638077 0.802384
+AGGCTG 71.308874 1.605306 1.618905 0.788338
+AGGCTT 71.984412 1.897865 2.005336 1.08683
+AGGGAA 72.877602 1.693773 1.48124 0.689952
+AGGGAC 69.876634 1.042663 1.33584 0.590898
+AGGGAG 72.123924 1.643588 1.531505 0.725368
+AGGGAT 72.192314 1.840954 1.414716 0.643998
+AGGGCA 63.955051 1.557946 1.231615 0.52311
+AGGGCC 62.492708 1.225101 1.151426 0.472863
+AGGGCG 63.598901 1.382521 1.233603 0.524377
+AGGGCT 64.672123 1.455698 1.29141 0.561665
+AGGGGA 71.811228 1.526604 1.391227 0.628026
+AGGGGC 69.260005 1.272565 1.3857 0.624288
+AGGGGG 71.453874 1.301223 1.315241 0.577283
+AGGGGT 71.275711 1.399267 1.415388 0.644457
+AGGGTA 69.337279 1.232214 1.486158 0.693391
+AGGGTC 68.32249 1.289545 1.627811 0.794853
+AGGGTG 69.128027 1.183684 1.548981 0.737819
+AGGGTT 70.062044 1.337825 1.795626 0.920883
+AGGTAA 58.268223 1.295188 1.222573 0.51736
+AGGTAC 56.737492 0.949491 1.165759 0.481719
+AGGTAG 57.852837 1.360152 1.217931 0.514416
+AGGTAT 57.750292 0.986504 1.226875 0.520093
+AGGTCA 50.492599 1.234785 1.587197 0.765291
+AGGTCC 49.277129 1.062216 1.556203 0.742985
+AGGTCG 50.367254 1.223139 1.54453 0.734641
+AGGTCT 50.085441 0.986687 1.505532 0.706994
+AGGTGA 57.457496 1.289604 1.247053 0.532976
+AGGTGC 56.10234 1.148124 1.439403 0.660928
+AGGTGG 56.324832 1.302655 1.162842 0.479912
+AGGTGT 56.257144 1.0482 1.258956 0.540625
+AGGTTA 51.984564 1.167353 1.493374 0.698447
+AGGTTC 50.192212 1.394576 1.738063 0.876958
+AGGTTG 51.51478 1.150227 1.463032 0.677269
+AGGTTT 51.756932 1.32965 1.665686 0.822755
+AGTAAA 62.846001 1.501125 1.186711 0.494764
+AGTAAC 62.217223 0.795222 1.005364 0.385803
+AGTAAG 62.81306 1.263243 1.161924 0.479344
+AGTAAT 63.48356 1.291326 1.179558 0.490298
+AGTACA 57.735286 1.005641 1.040171 0.406011
+AGTACC 57.111735 0.918885 0.933275 0.34506
+AGTACG 57.544424 1.045737 1.006336 0.386363
+AGTACT 57.809808 0.96334 0.957009 0.358307
+AGTAGA 62.408967 1.370986 1.193264 0.498868
+AGTAGC 62.527562 0.906532 1.132016 0.460956
+AGTAGG 62.436416 1.282581 1.070661 0.423993
+AGTAGT 63.021003 1.488707 1.196144 0.500675
+AGTATA 60.164515 0.859774 0.968472 0.364764
+AGTATC 59.350699 1.143435 1.119012 0.453036
+AGTATG 59.890744 0.909377 1.05248 0.413239
+AGTATT 60.130729 1.176832 1.254789 0.537944
+AGTCAA 57.450554 2.154386 1.322203 0.581872
+AGTCAC 57.549592 1.738184 1.262931 0.543188
+AGTCAG 57.141061 1.997482 1.421446 0.648599
+AGTCAT 57.766257 1.760062 1.321765 0.581583
+AGTCCA 53.995684 1.450145 1.323666 0.582839
+AGTCCC 53.251179 1.463448 1.19905 0.502501
+AGTCCG 53.494498 1.418807 1.321369 0.581322
+AGTCCT 53.416264 1.859415 1.266685 0.545612
+AGTCGA 56.904026 2.109758 1.441639 0.662469
+AGTCGC 57.016875 2.185603 1.318483 0.579419
+AGTCGG 56.519293 1.699059 1.364912 0.610292
+AGTCGT 56.815053 1.928378 1.470509 0.682468
+AGTCTA 55.584754 1.228114 1.129841 0.459628
+AGTCTC 54.764407 1.656199 1.10822 0.446498
+AGTCTG 54.872383 1.580982 1.222575 0.517361
+AGTCTT 55.783552 1.313683 1.196558 0.500935
+AGTGAA 55.770359 1.219004 1.22155 0.516711
+AGTGAC 53.993913 0.739499 0.929968 0.343228
+AGTGAG 55.212295 1.140926 1.175799 0.487956
+AGTGAT 55.198606 0.925979 1.057005 0.415907
+AGTGCA 50.658745 0.85482 1.409298 0.640302
+AGTGCC 49.831694 0.791883 1.243846 0.530922
+AGTGCG 50.540607 0.832404 1.333457 0.589317
+AGTGCT 50.755989 0.714343 1.140691 0.466265
+AGTGGA 55.801384 1.30384 1.205415 0.506507
+AGTGGC 55.428581 0.829659 0.945993 0.352138
+AGTGGG 55.528324 0.996175 0.977742 0.370013
+AGTGGT 56.156658 0.957867 1.020297 0.394431
+AGTGTA 53.843943 0.778757 0.92458 0.340249
+AGTGTC 53.042271 0.892221 1.041755 0.406938
+AGTGTG 53.768906 0.742444 0.856218 0.303219
+AGTGTT 54.030374 0.835166 1.028581 0.399244
+AGTTAA 49.987092 0.96357 1.152949 0.473801
+AGTTAC 49.210759 0.675858 1.0029 0.384385
+AGTTAG 49.64312 0.931902 1.205946 0.506842
+AGTTAT 49.67167 0.755594 0.983746 0.373427
+AGTTCA 44.663951 0.790743 1.348753 0.599486
+AGTTCC 43.763128 0.723322 1.218278 0.514636
+AGTTCG 44.445025 0.769166 1.320763 0.580922
+AGTTCT 44.380305 0.695919 1.174609 0.487215
+AGTTGA 49.2522 0.898257 1.019282 0.393842
+AGTTGC 48.551873 0.670836 0.941954 0.349885
+AGTTGG 48.572968 0.80925 1.002056 0.3839
+AGTTGT 48.503893 0.757611 0.948753 0.35368
+AGTTTA 45.449278 0.756131 0.940268 0.348946
+AGTTTC 44.25391 0.658224 1.021414 0.395079
+AGTTTG 45.103284 0.670228 0.860288 0.305384
+AGTTTT 45.050482 0.659268 0.827884 0.288293
+ATAAAA 66.078339 0.681397 0.804632 0.276234
+ATAAAC 63.439627 0.769896 0.945962 0.352121
+ATAAAG 65.385437 0.72793 0.79876 0.273215
+ATAAAT 65.257211 0.709929 0.904969 0.329481
+ATAACA 59.288143 0.738302 0.767308 0.257238
+ATAACC 58.146847 0.832035 0.827219 0.287946
+ATAACG 58.984224 0.722857 0.768087 0.25763
+ATAACT 59.2961 0.776172 0.756221 0.251683
+ATAAGA 67.305681 0.823798 0.878756 0.31527
+ATAAGC 66.022762 0.762541 0.980866 0.371788
+ATAAGG 66.566328 0.703414 0.81842 0.283364
+ATAAGT 66.890752 0.860829 1.11159 0.448536
+ATAATA 63.876298 0.821883 0.938313 0.347858
+ATAATC 63.07417 0.974004 1.05973 0.417516
+ATAATG 63.625408 0.80073 1.016367 0.392154
+ATAATT 64.284439 0.831509 1.227952 0.520778
+ATACAA 65.881039 1.134443 0.967375 0.364144
+ATACAC 65.497264 0.823033 0.827843 0.288272
+ATACAG 65.384911 1.170664 0.98441 0.373805
+ATACAT 65.700819 1.151011 1.022607 0.395771
+ATACCA 61.658497 0.693112 0.744526 0.245867
+ATACCC 60.807026 0.609721 0.659509 0.20498
+ATACCG 61.369633 0.713981 0.743823 0.245519
+ATACCT 61.45507 0.636146 0.690209 0.219458
+ATACGA 65.605768 1.208066 0.916381 0.335734
+ATACGC 65.031748 0.821548 0.823348 0.285928
+ATACGG 64.681036 1.062633 0.917666 0.33644
+ATACGT 65.075812 0.982658 0.969322 0.365244
+ATACTA 63.517336 0.723616 0.724451 0.23599
+ATACTC 62.828735 0.770287 0.835744 0.292409
+ATACTG 63.065953 0.712945 0.83955 0.294409
+ATACTT 63.416232 0.87501 1.089461 0.435209
+ATAGAA 65.526031 0.94851 0.955773 0.357613
+ATAGAC 63.53794 1.021862 0.863876 0.307297
+ATAGAG 64.92011 0.860315 0.928584 0.342462
+ATAGAT 64.837519 0.741496 0.949631 0.354171
+ATAGCA 59.603228 0.744846 1.053623 0.413912
+ATAGCC 58.53311 0.763497 0.93669 0.346956
+ATAGCG 59.4864 0.854866 1.03534 0.403186
+ATAGCT 59.769199 0.730356 0.939943 0.348765
+ATAGGA 65.222966 0.920297 0.842532 0.295978
+ATAGGC 64.036251 0.764675 0.973575 0.36765
+ATAGGG 64.720092 0.817904 0.79746 0.272549
+ATAGGT 65.092991 0.743804 0.913854 0.334346
+ATAGTA 62.823756 0.864302 0.923878 0.339862
+ATAGTC 61.700399 1.110136 1.14696 0.470114
+ATAGTG 62.602718 0.899888 1.0266 0.398091
+ATAGTT 63.031826 0.979735 1.188091 0.495627
+ATATAA 59.260043 0.847143 0.761619 0.254383
+ATATAC 57.750279 0.672006 0.712838 0.230339
+ATATAG 59.019426 0.842612 0.78404 0.265698
+ATATAT 58.798143 0.716583 0.747588 0.247385
+ATATCA 53.804813 1.011142 1.007412 0.386982
+ATATCC 52.48097 0.813262 0.980888 0.371801
+ATATCG 53.614747 0.986988 1.007573 0.387075
+ATATCT 53.393127 0.819889 0.902733 0.328261
+ATATGA 58.24831 0.934469 0.854148 0.302121
+ATATGC 56.366068 1.115639 1.045626 0.409209
+ATATGG 57.465279 1.093723 0.785089 0.266231
+ATATGT 57.074969 0.971665 0.862903 0.306778
+ATATTA 54.05826 1.155487 1.034478 0.402682
+ATATTC 52.275296 1.345807 1.215797 0.513065
+ATATTG 53.740466 1.214784 0.976007 0.369028
+ATATTT 53.599752 1.284188 1.095973 0.439117
+ATCAAA 66.228255 0.719307 0.91352 0.334162
+ATCAAC 64.000594 0.75266 1.045045 0.408868
+ATCAAG 65.741189 0.676662 0.929352 0.342887
+ATCAAT 65.687537 0.708433 0.970959 0.36617
+ATCACA 62.61013 0.601565 0.844458 0.296994
+ATCACC 61.559492 0.66346 0.825858 0.287236
+ATCACG 62.353021 0.62462 0.82544 0.287018
+ATCACT 62.570967 0.703599 0.856742 0.303498
+ATCAGA 68.28498 0.963739 1.095167 0.438633
+ATCAGC 67.000503 1.054339 1.156336 0.47589
+ATCAGG 67.712895 0.868756 1.00578 0.386043
+ATCAGT 68.120504 0.960037 1.175649 0.487862
+ATCATA 65.955601 0.883399 0.963537 0.361979
+ATCATC 65.316305 0.812241 1.186205 0.494447
+ATCATG 65.800483 0.808468 1.097613 0.440103
+ATCATT 66.221441 0.962451 1.359451 0.606633
+ATCCAA 65.741134 1.673968 1.243833 0.530913
+ATCCAC 65.248608 1.014348 1.048847 0.411101
+ATCCAG 65.480316 1.475209 1.233614 0.524384
+ATCCAT 65.591633 1.466511 1.175059 0.487495
+ATCCCA 62.486551 1.276326 1.009249 0.388041
+ATCCCC 61.819171 1.076651 0.886911 0.319669
+ATCCCG 62.197777 1.215418 1.013719 0.390622
+ATCCCT 62.547907 1.146401 0.994157 0.37937
+ATCCGA 65.800101 1.727506 1.200252 0.503257
+ATCCGC 65.413934 1.246413 1.089748 0.435381
+ATCCGG 65.187317 1.450518 1.242303 0.529934
+ATCCGT 65.540109 1.646865 1.293902 0.563291
+ATCCTA 64.392096 0.89778 0.916864 0.335999
+ATCCTC 63.408548 1.04351 1.00458 0.385352
+ATCCTG 63.836282 1.020984 1.092676 0.437137
+ATCCTT 63.733714 1.276768 1.292508 0.562381
+ATCGAA 67.116519 1.095062 1.019311 0.393859
+ATCGAC 65.681051 0.679255 0.828207 0.288462
+ATCGAG 66.760378 1.102805 1.020812 0.394729
+ATCGAT 67.009373 1.002644 1.058564 0.416827
+ATCGCA 62.721378 0.742234 0.915205 0.335087
+ATCGCC 61.853714 0.642095 0.772998 0.260105
+ATCGCG 62.499918 0.716157 0.89854 0.325977
+ATCGCT 62.882539 0.699777 0.872149 0.311722
+ATCGGA 66.307333 0.970635 1.047782 0.410475
+ATCGGC 65.231268 1.017184 1.22675 0.520014
+ATCGGG 66.12402 0.938012 1.0047 0.385421
+ATCGGT 66.183099 1.083515 1.242593 0.53012
+ATCGTA 64.175594 0.887292 1.107896 0.446302
+ATCGTC 62.931252 0.967628 1.312471 0.57546
+ATCGTG 63.906172 0.88729 1.221493 0.516675
+ATCGTT 64.139528 0.969084 1.420297 0.647812
+ATCTAA 61.17534 0.764615 0.716718 0.232222
+ATCTAC 59.975972 0.519242 0.669352 0.209586
+ATCTAG 60.804926 0.707063 0.773301 0.260258
+ATCTAT 60.678853 0.619854 0.735864 0.241589
+ATCTCA 56.817206 0.675733 0.852925 0.301472
+ATCTCC 55.912147 0.691377 0.785679 0.266531
+ATCTCG 56.647161 0.675838 0.822803 0.285644
+ATCTCT 56.494668 0.649777 0.756527 0.251836
+ATCTGA 59.479028 0.750474 0.83984 0.294561
+ATCTGC 57.656221 0.95784 1.049076 0.411236
+ATCTGG 58.959136 0.693847 0.765778 0.256469
+ATCTGT 58.560771 0.758843 0.882054 0.317047
+ATCTTA 55.772518 1.093386 0.952915 0.35601
+ATCTTC 54.102187 1.211779 1.098523 0.440651
+ATCTTG 55.773398 0.924082 0.883362 0.317752
+ATCTTT 55.372377 1.042869 1.006937 0.386709
+ATGAAA 73.752807 1.977455 1.994708 1.078201
+ATGAAC 70.964993 1.788846 1.79048 0.916927
+ATGAAG 73.545103 1.847166 1.975418 1.062599
+ATGAAT 73.373742 2.035487 2.034181 1.110363
+ATGACA 62.684597 1.506732 1.005482 0.385871
+ATGACC 61.775891 1.047136 1.04492 0.408795
+ATGACG 62.496181 1.332284 1.006856 0.386662
+ATGACT 63.281949 1.103088 1.103504 0.443651
+ATGAGA 72.502059 1.860618 1.933401 1.028877
+ATGAGC 69.797762 1.988846 1.773386 0.903827
+ATGAGG 71.63414 2.034583 1.910538 1.010681
+ATGAGT 71.848155 1.911894 2.071165 1.140782
+ATGATA 66.802964 1.778739 1.593469 0.769832
+ATGATC 66.419624 1.705742 1.709095 0.855125
+ATGATG 66.640812 1.800378 1.66932 0.825449
+ATGATT 68.1121 1.736828 1.959914 1.050113
+ATGCAA 71.23099 2.050704 1.997199 1.080221
+ATGCAC 69.88098 1.974574 1.885366 0.990773
+ATGCAG 70.257474 2.197355 1.896571 0.999619
+ATGCAT 70.875757 2.127442 1.930055 1.026208
+ATGCCA 64.516002 2.197355 1.465448 0.678948
+ATGCCC 63.914672 2.13965 1.349162 0.599759
+ATGCCG 63.828607 2.169758 1.440813 0.6619
+ATGCCT 64.646551 2.185089 1.404542 0.637063
+ATGCGA 70.540857 2.197355 1.852784 0.965201
+ATGCGC 69.278619 1.943735 1.813475 0.934648
+ATGCGG 69.284572 2.197355 1.875636 0.983113
+ATGCGT 69.663788 1.879423 2.024493 1.102441
+ATGCTA 67.864089 1.58092 1.709532 0.855454
+ATGCTC 66.618802 2.041228 1.818341 0.938412
+ATGCTG 66.916591 1.852487 1.779297 0.90835
+ATGCTT 67.245543 1.997595 2.018989 1.097947
+ATGGAA 65.363281 1.641034 1.374174 0.616514
+ATGGAC 62.327077 0.977122 0.976134 0.369101
+ATGGAG 64.627007 1.62814 1.343292 0.595849
+ATGGAT 64.599641 1.352359 1.323999 0.583059
+ATGGCA 57.859712 0.940959 1.211523 0.510362
+ATGGCC 56.711347 0.782461 0.980041 0.371319
+ATGGCG 57.492296 0.928073 1.18134 0.491409
+ATGGCT 58.108179 0.884016 1.0648 0.420516
+ATGGGA 63.855941 1.27747 1.212213 0.510798
+ATGGGC 61.268372 0.866726 1.081899 0.430686
+ATGGGG 63.000927 1.247795 1.10396 0.443926
+ATGGGT 63.456314 0.972392 1.146832 0.470035
+ATGGTA 61.538361 0.994913 1.22673 0.520001
+ATGGTC 60.127506 0.963629 1.347095 0.598381
+ATGGTG 61.228768 0.956466 1.173102 0.486277
+ATGGTT 61.911191 1.035269 1.421626 0.648722
+ATGTAA 51.683617 0.958703 1.05239 0.413186
+ATGTAC 50.470091 0.737935 1.099722 0.441372
+ATGTAG 51.450662 0.992836 1.149389 0.471608
+ATGTAT 51.252307 0.686059 0.991553 0.377881
+ATGTCA 45.12197 1.150499 1.494758 0.699418
+ATGTCC 43.767075 1.100381 1.394946 0.630546
+ATGTCG 44.911241 1.324725 1.499402 0.70268
+ATGTCT 44.670885 1.070344 1.388119 0.625923
+ATGTGA 50.753373 0.894577 0.963369 0.361884
+ATGTGC 49.168458 0.784743 1.150358 0.472204
+ATGTGG 49.808944 0.934403 1.032861 0.401739
+ATGTGT 49.831865 0.656775 0.951046 0.354963
+ATGTTA 46.032267 0.734316 1.029588 0.399831
+ATGTTC 44.715253 0.834773 1.296805 0.565188
+ATGTTG 45.693678 0.740519 1.017663 0.392904
+ATGTTT 45.79673 0.823927 1.108048 0.446394
+ATTAAA 63.307021 1.868132 1.400531 0.634336
+ATTAAC 62.490475 1.022279 1.243746 0.530858
+ATTAAG 63.265238 1.60352 1.490559 0.696473
+ATTAAT 63.721622 1.751902 1.400325 0.634196
+ATTACA 58.384049 1.328519 1.123152 0.455552
+ATTACC 57.824919 1.239835 0.997786 0.381449
+ATTACG 58.322774 1.271082 1.126883 0.457824
+ATTACT 58.607363 1.255491 1.138948 0.465196
+ATTAGA 63.345036 1.879177 1.363854 0.609583
+ATTAGC 62.953496 1.180916 1.384886 0.623737
+ATTAGG 63.336126 1.955515 1.464067 0.677988
+ATTAGT 63.786004 1.723554 1.518836 0.716386
+ATTATA 60.846819 0.969033 1.199345 0.502686
+ATTATC 59.95937 1.25272 1.220909 0.516304
+ATTATG 60.730096 1.071036 1.224542 0.51861
+ATTATT 60.794115 1.285719 1.435608 0.658316
+ATTCAA 59.063526 2.197355 1.434543 0.657584
+ATTCAC 58.656954 2.147268 1.273303 0.549893
+ATTCAG 58.588423 2.197355 1.473243 0.684372
+ATTCAT 59.253059 2.186887 1.475426 0.685893
+ATTCCA 55.31032 1.926124 1.38234 0.622018
+ATTCCC 54.606882 2.097922 1.313034 0.575831
+ATTCCG 55.011436 1.873693 1.31284 0.575703
+ATTCCT 55.253253 2.080809 1.344102 0.596388
+ATTCGA 58.686193 2.156013 1.374824 0.616952
+ATTCGC 58.74004 1.875128 1.389406 0.626793
+ATTCGG 58.601718 2.197355 1.39739 0.632204
+ATTCGT 58.7773 2.103723 1.66207 0.820077
+ATTCTA 56.843189 2.028284 1.303947 0.569863
+ATTCTC 56.787657 1.707842 1.235487 0.525579
+ATTCTG 56.350336 1.959968 1.283327 0.556399
+ATTCTT 57.255497 1.612517 1.330717 0.587502
+ATTGAA 55.641169 1.417729 1.242598 0.530123
+ATTGAC 53.432058 0.853265 0.840041 0.294667
+ATTGAG 54.975101 1.404612 1.170691 0.484779
+ATTGAT 54.677892 1.122409 1.027872 0.398831
+ATTGCA 50.512559 0.947322 1.436113 0.658663
+ATTGCC 49.630386 0.780039 1.106391 0.445393
+ATTGCG 50.406742 0.904021 1.274047 0.550375
+ATTGCT 50.482747 0.854439 1.081534 0.430468
+ATTGGA 55.702193 1.552679 1.194158 0.499429
+ATTGGC 54.956652 1.16089 0.958267 0.359013
+ATTGGG 55.307821 1.272449 1.021152 0.394927
+ATTGGT 55.961144 1.298443 1.085706 0.432961
+ATTGTA 53.840865 0.909773 0.897018 0.325149
+ATTGTC 52.832073 0.841325 0.950178 0.354477
+ATTGTG 53.572438 0.868688 0.869588 0.310349
+ATTGTT 53.767345 1.055209 1.067485 0.422108
+ATTTAA 49.863024 1.168924 1.062767 0.419312
+ATTTAC 49.071869 0.73848 0.916023 0.335537
+ATTTAG 49.49785 1.080864 1.076897 0.427703
+ATTTAT 49.413332 0.883542 0.919913 0.337676
+ATTTCA 44.621366 0.774008 1.270431 0.548034
+ATTTCC 43.544746 0.589306 1.04012 0.405981
+ATTTCG 44.452087 0.789483 1.258514 0.54034
+ATTTCT 44.187642 0.666672 1.038491 0.405028
+ATTTGA 48.981882 0.996989 0.939479 0.348507
+ATTTGC 48.298286 0.661722 0.843887 0.296693
+ATTTGG 48.447052 0.918675 0.929159 0.34278
+ATTTGT 48.519908 0.730215 0.755765 0.251455
+ATTTTA 45.37608 0.774038 0.780492 0.263896
+ATTTTC 44.066821 0.578971 0.838729 0.293977
+ATTTTG 45.038771 0.625523 0.721848 0.23472
+ATTTTT 44.764886 0.523609 0.666724 0.208353
+CAAAAA 64.450563 0.813603 0.815089 0.281636
+CAAAAC 62.030469 0.676604 0.887102 0.319772
+CAAAAG 64.088987 0.754982 0.850461 0.300166
+CAAAAT 64.163033 0.716408 0.873801 0.312608
+CAAACA 56.832478 0.97778 1.056844 0.415812
+CAAACC 55.593251 0.947248 0.933692 0.345292
+CAAACG 56.642276 0.963396 1.037025 0.40417
+CAAACT 56.769787 0.774885 0.890395 0.321555
+CAAAGA 65.044847 1.029146 0.864321 0.307534
+CAAAGC 63.716926 0.835835 0.978191 0.370268
+CAAAGG 64.496233 0.897993 0.854831 0.302483
+CAAAGT 64.869324 0.706575 1.016291 0.39211
+CAAATA 60.566645 0.925293 0.972693 0.367151
+CAAATC 59.518677 1.151075 1.083347 0.431551
+CAAATG 60.380368 0.933428 0.983357 0.373205
+CAAATT 61.021235 0.967854 1.095199 0.438652
+CAACAA 62.945002 1.509234 0.942976 0.350455
+CAACAC 61.909912 1.542228 0.873606 0.312503
+CAACAG 62.742571 1.438986 0.99328 0.378868
+CAACAT 63.113905 1.448068 1.00994 0.38844
+CAACCA 58.481314 1.021123 0.938717 0.348083
+CAACCC 57.575535 1.118813 0.897401 0.325357
+CAACCG 58.212788 1.027723 0.939738 0.348651
+CAACCT 58.317817 1.019019 0.832379 0.290645
+CAACGA 62.6343 1.485366 0.969849 0.365542
+CAACGC 61.522604 1.313783 0.862975 0.306816
+CAACGG 61.941236 1.297719 0.992606 0.378483
+CAACGT 61.906641 1.391919 1.019456 0.393943
+CAACTA 60.176438 1.223747 0.782261 0.264794
+CAACTC 59.570194 0.90288 0.844354 0.296939
+CAACTG 60.108524 0.796768 0.768606 0.257891
+CAACTT 60.164821 0.880489 0.988415 0.376088
+CAAGAA 64.221825 0.874811 0.86989 0.310511
+CAAGAC 61.92665 0.777439 0.859981 0.305221
+CAAGAG 63.651354 0.931577 0.923666 0.339745
+CAAGAT 63.97881 0.794651 1.005053 0.385624
+CAAGCA 58.01132 1.130794 1.263937 0.543837
+CAAGCC 56.98532 1.048012 1.206779 0.507367
+CAAGCG 57.825476 1.025241 1.178366 0.489555
+CAAGCT 58.159012 0.966026 1.108305 0.44655
+CAAGGA 63.309066 0.820063 0.911602 0.333111
+CAAGGC 62.036319 0.719072 0.953975 0.356604
+CAAGGG 62.85478 0.800425 0.831278 0.290068
+CAAGGT 63.455322 0.747388 0.861589 0.306077
+CAAGTA 59.839229 1.173757 1.112362 0.449003
+CAAGTC 57.959332 1.434694 1.310608 0.574235
+CAAGTG 59.732572 1.153199 1.05291 0.413493
+CAAGTT 59.702166 1.307012 1.221493 0.516675
+CAATAA 55.61732 1.262393 1.172411 0.485848
+CAATAC 54.230941 1.092282 1.158197 0.47704
+CAATAG 55.441988 1.311675 1.181495 0.491506
+CAATAT 55.181143 1.147755 1.127994 0.458502
+CAATCA 50.083316 1.571006 1.592716 0.769286
+CAATCC 48.990566 1.405252 1.492054 0.697522
+CAATCG 49.993784 1.579524 1.517278 0.715284
+CAATCT 49.800642 1.421357 1.448811 0.667419
+CAATGA 53.94869 1.184808 1.078567 0.428698
+CAATGC 52.483856 1.417114 1.327613 0.585448
+CAATGG 53.335269 1.144529 1.119568 0.453374
+CAATGT 52.934048 1.027976 1.072295 0.424964
+CAATTA 49.739271 1.531416 1.400297 0.634178
+CAATTC 48.055931 1.754649 1.706617 0.853266
+CAATTG 49.560926 1.708723 1.294323 0.563566
+CAATTT 49.050894 1.577583 1.544416 0.73456
+CACAAA 67.830876 0.692364 0.962076 0.361156
+CACAAC 65.10333 1.005885 1.082758 0.431199
+CACAAG 67.333977 0.778693 0.965637 0.363163
+CACAAT 67.308661 0.825785 1.078257 0.428513
+CACACA 63.725745 0.739736 0.880484 0.316201
+CACACC 62.513305 0.704161 0.829654 0.289218
+CACACG 63.44112 0.689371 0.839836 0.294559
+CACACT 63.710525 0.735997 0.85488 0.302509
+CACAGA 69.964454 0.849205 0.934739 0.345873
+CACAGC 68.480466 0.72079 1.0558 0.415196
+CACAGG 69.37364 0.74409 0.90706 0.330624
+CACAGT 69.63652 0.889511 1.254832 0.537971
+CACATA 67.316486 0.648334 0.948244 0.353395
+CACATC 66.185217 0.980918 1.088788 0.434806
+CACATG 66.926423 0.697427 1.133078 0.461605
+CACATT 67.422332 0.865601 1.300365 0.567517
+CACCAA 68.332885 1.289713 0.978396 0.370384
+CACCAC 67.006511 1.061849 0.822347 0.285406
+CACCAG 67.706088 1.502107 0.984755 0.374001
+CACCAT 68.111629 1.453449 1.032821 0.401715
+CACCCA 64.394599 1.206248 0.773226 0.26022
+CACCCC 63.512249 1.228682 0.70148 0.224856
+CACCCG 64.156071 1.201081 0.792624 0.270073
+CACCCT 64.200147 1.208534 0.796265 0.271936
+CACCGA 67.877552 1.633705 0.941981 0.3499
+CACCGC 67.060639 1.123151 0.858296 0.304324
+CACCGG 67.361055 1.419937 0.960471 0.360252
+CACCGT 67.710144 1.309683 1.12854 0.458835
+CACCTA 66.035979 1.051458 0.785341 0.26636
+CACCTC 64.802853 0.999272 0.82841 0.288568
+CACCTG 65.333916 0.996345 0.92881 0.342587
+CACCTT 65.460431 1.072366 1.207334 0.507717
+CACGAA 69.0586 1.015589 0.88503 0.318653
+CACGAC 67.192365 0.66397 0.856991 0.30363
+CACGAG 68.686671 0.902304 0.92902 0.342703
+CACGAT 68.965333 0.919511 1.047608 0.410373
+CACGCA 63.650993 0.72463 0.872978 0.312166
+CACGCC 62.73691 0.658961 0.771624 0.259411
+CACGCG 63.555864 0.730585 0.867796 0.309391
+CACGCT 63.970039 0.749136 0.869674 0.310395
+CACGGA 67.77556 0.874286 0.884634 0.318439
+CACGGC 66.242712 0.838726 1.089774 0.435397
+CACGGG 67.461357 0.859471 0.957622 0.358651
+CACGGT 67.663894 0.858796 1.162871 0.47993
+CACGTA 64.053698 1.143601 1.1847 0.493507
+CACGTC 61.503265 1.921773 1.536766 0.729108
+CACGTG 63.538685 1.318195 1.133066 0.461598
+CACGTT 63.567891 1.488641 1.437026 0.659292
+CACTAA 61.501033 0.790755 0.742012 0.244623
+CACTAC 59.826244 0.673874 0.741661 0.24445
+CACTAG 61.287274 0.895266 0.727024 0.237249
+CACTAT 60.893671 0.589806 0.777959 0.262613
+CACTCA 56.675406 0.99274 1.124988 0.45667
+CACTCC 55.547598 0.956663 1.098571 0.440679
+CACTCG 56.539529 1.042576 1.117086 0.451867
+CACTCT 56.260552 0.982754 1.036442 0.403829
+CACTGA 58.89251 1.099616 0.977591 0.369928
+CACTGC 56.42889 1.514144 1.24692 0.532891
+CACTGG 58.510968 1.052149 0.858322 0.304338
+CACTGT 57.788171 1.083975 0.996737 0.380848
+CACTTA 54.814708 1.486713 1.252558 0.53651
+CACTTC 52.351681 1.956986 1.585777 0.764264
+CACTTG 54.547665 1.449535 1.179366 0.490178
+CACTTT 53.708743 1.681488 1.372822 0.615605
+CAGAAA 73.404551 1.406387 1.394742 0.630408
+CAGAAC 70.792033 1.063081 1.363087 0.609068
+CAGAAG 73.126021 1.359543 1.336589 0.591395
+CAGAAT 73.231543 1.488628 1.616643 0.786686
+CAGACA 61.801959 0.881263 0.926776 0.341463
+CAGACC 60.513307 0.791084 0.963322 0.361858
+CAGACG 61.394879 0.858027 0.890264 0.321484
+CAGACT 62.076686 0.840306 1.014788 0.39124
+CAGAGA 72.29743 1.439578 1.386299 0.624692
+CAGAGC 69.82286 1.106032 1.340687 0.594117
+CAGAGG 71.370234 1.471527 1.348198 0.599117
+CAGAGT 71.816021 1.36583 1.478904 0.68832
+CAGATA 65.888698 1.057352 1.365448 0.610651
+CAGATC 64.635093 1.504461 1.397222 0.63209
+CAGATG 65.683464 1.079512 1.351863 0.601561
+CAGATT 66.736873 1.148912 1.619031 0.78843
+CAGCAA 70.378233 1.733821 1.321356 0.581313
+CAGCAC 68.921049 1.598972 1.296642 0.565081
+CAGCAG 69.354758 2.099107 1.264849 0.544426
+CAGCAT 70.288084 1.625416 1.354708 0.603461
+CAGCCA 63.943681 1.324922 1.00999 0.388469
+CAGCCC 62.967813 1.21177 0.918627 0.336968
+CAGCCG 63.682371 1.297349 1.003537 0.384752
+CAGCCT 63.25396 1.605492 1.067029 0.421837
+CAGCGA 69.573263 2.197355 1.251036 0.535532
+CAGCGC 68.323039 1.619765 1.266474 0.545475
+CAGCGG 68.622142 1.871491 1.271708 0.54886
+CAGCGT 68.743294 1.641931 1.378776 0.619614
+CAGCTA 66.784822 1.413755 1.247759 0.533429
+CAGCTC 65.788798 1.290002 1.2446 0.531405
+CAGCTG 65.937671 1.464836 1.318262 0.579273
+CAGCTT 66.278107 1.682513 1.497622 0.70143
+CAGGAA 67.64051 1.516861 1.251519 0.535842
+CAGGAC 63.968099 0.889657 1.002064 0.383905
+CAGGAG 66.664027 1.592108 1.23644 0.526187
+CAGGAT 67.002014 1.41462 1.291345 0.561622
+CAGGCA 59.277191 1.079919 1.246946 0.532908
+CAGGCC 57.995722 0.928655 1.188545 0.495911
+CAGGCG 58.94312 1.02154 1.249526 0.534562
+CAGGCT 59.671376 1.105556 1.199893 0.503031
+CAGGGA 65.285657 1.260693 1.074925 0.426529
+CAGGGC 62.884035 0.960997 1.105578 0.444903
+CAGGGG 64.663519 1.236218 1.02507 0.397202
+CAGGGT 65.503982 1.063842 1.183278 0.492618
+CAGGTA 62.173067 0.993499 1.118959 0.453004
+CAGGTC 60.283854 1.240106 1.379386 0.620025
+CAGGTG 62.039052 0.978702 1.143634 0.468071
+CAGGTT 62.217351 1.082319 1.300326 0.567491
+CAGTAA 51.302458 1.559373 1.470231 0.682275
+CAGTAC 50.006113 1.427371 1.470867 0.682717
+CAGTAG 50.879662 1.588445 1.513989 0.712959
+CAGTAT 50.769277 1.374029 1.40142 0.634941
+CAGTCA 44.79707 1.790349 1.883912 0.989627
+CAGTCC 43.747224 1.617009 1.7737 0.904068
+CAGTCG 44.598272 1.668474 1.837349 0.953165
+CAGTCT 44.601652 1.701192 1.728687 0.869872
+CAGTGA 50.039283 1.34202 1.433322 0.656744
+CAGTGC 48.561956 1.173589 1.357253 0.605162
+CAGTGG 49.48884 1.454739 1.439467 0.660972
+CAGTGT 49.400563 1.240847 1.371471 0.614696
+CAGTTA 45.369638 1.187927 1.478467 0.688016
+CAGTTC 43.926972 1.425687 1.511711 0.71135
+CAGTTG 45.086172 1.232668 1.401649 0.635097
+CAGTTT 44.901423 1.421655 1.377374 0.618669
+CATAAA 64.721282 1.175701 0.859635 0.305036
+CATAAC 62.958402 0.749639 0.811438 0.279746
+CATAAG 64.713992 1.129413 0.90162 0.327655
+CATAAT 65.022324 0.935271 0.932455 0.344606
+CATACA 59.267942 0.971976 0.821985 0.285218
+CATACC 58.492252 0.773114 0.785306 0.266342
+CATACG 59.162048 0.8568 0.81964 0.283998
+CATACT 59.480836 0.857235 0.793739 0.270643
+CATAGA 64.860406 1.339292 0.935087 0.346066
+CATAGC 63.534752 0.861175 0.93254 0.344653
+CATAGG 64.566189 1.060826 0.907286 0.330748
+CATAGT 65.03007 0.88322 0.95826 0.359009
+CATATA 61.343614 0.752479 0.784439 0.265901
+CATATC 60.436035 0.607414 0.897266 0.325284
+CATATG 61.118361 0.766587 0.849938 0.299889
+CATATT 61.424693 0.792078 1.067564 0.422155
+CATCAA 61.477308 1.905921 1.162472 0.479683
+CATCAC 60.400684 2.197355 1.021269 0.394994
+CATCAG 61.454314 2.113551 1.234371 0.524867
+CATCAT 61.615468 1.928125 1.236557 0.526262
+CATCCA 57.547599 1.520326 1.076894 0.427701
+CATCCC 56.778031 1.359073 0.99106 0.377599
+CATCCG 57.494354 1.513059 1.118087 0.452475
+CATCCT 57.372042 1.504824 1.079386 0.429186
+CATCGA 61.397442 1.89633 1.257205 0.539498
+CATCGC 59.923844 1.84798 1.064948 0.420604
+CATCGG 60.563033 1.820219 1.183559 0.492794
+CATCGT 60.73882 1.84965 1.275906 0.55158
+CATCTA 58.772859 1.25976 0.926091 0.341084
+CATCTC 58.075181 1.046526 0.857196 0.303739
+CATCTG 58.168354 1.613425 0.984526 0.37387
+CATCTT 58.708363 1.165338 1.075849 0.427079
+CATGAA 56.95985 1.353008 1.114057 0.45003
+CATGAC 54.269854 0.750244 0.997819 0.381468
+CATGAG 56.191438 1.068398 1.067783 0.422284
+CATGAT 56.042167 1.108154 1.121184 0.454356
+CATGCA 50.919856 1.01853 1.418352 0.646483
+CATGCC 49.80438 0.889037 1.244283 0.531202
+CATGCG 50.703742 0.916552 1.363864 0.609589
+CATGCT 50.996715 0.928759 1.259513 0.540984
+CATGGA 56.861103 1.258889 1.049454 0.411458
+CATGGC 55.881011 0.742944 0.851769 0.300859
+CATGGG 56.43277 1.074827 0.934235 0.345593
+CATGGT 57.054435 1.079401 1.002037 0.383889
+CATGTA 53.849777 0.748808 0.962338 0.361303
+CATGTC 52.519041 0.761322 1.07688 0.427693
+CATGTG 53.729505 0.751568 0.87041 0.31079
+CATGTT 53.992829 0.69895 0.996909 0.380946
+CATTAA 49.983546 0.951877 1.16038 0.478389
+CATTAC 48.910962 0.675255 0.999272 0.382302
+CATTAG 49.662364 0.913486 1.143058 0.467717
+CATTAT 49.504347 0.72093 1.013314 0.390388
+CATTCA 44.219965 0.914782 1.490216 0.696233
+CATTCC 43.230421 0.806831 1.404673 0.637153
+CATTCG 44.236761 0.885009 1.531892 0.725643
+CATTCT 43.948509 0.909204 1.299123 0.566703
+CATTGA 48.973269 0.910962 1.094059 0.437967
+CATTGC 47.923704 0.605046 0.90858 0.331455
+CATTGG 48.468999 0.85891 1.059028 0.417102
+CATTGT 48.434092 0.683319 0.956031 0.357758
+CATTTA 44.668622 0.825007 1.102334 0.442946
+CATTTC 43.13872 0.70485 1.040117 0.40598
+CATTTG 44.442284 0.783615 1.044886 0.408775
+CATTTT 44.012451 0.721729 0.928944 0.342661
+CCAAAA 65.183049 0.860844 0.899593 0.32655
+CCAAAC 61.677731 0.75628 1.070493 0.423893
+CCAAAG 64.499603 0.855558 0.911788 0.333213
+CCAAAT 64.029161 0.701625 1.034609 0.402759
+CCAACA 58.46339 0.814032 1.083795 0.431818
+CCAACC 57.03957 0.722367 1.013044 0.390232
+CCAACG 58.154527 0.79067 1.040103 0.405971
+CCAACT 58.234219 0.705496 0.969277 0.365218
+CCAAGA 65.980342 1.539023 0.967785 0.364375
+CCAAGC 64.645289 0.763449 1.087585 0.434085
+CCAAGG 66.025819 0.823935 0.936072 0.346613
+CCAAGT 66.374329 0.973419 1.229742 0.521917
+CCAATA 62.308826 0.876154 1.052294 0.413129
+CCAATC 60.938983 1.227266 1.239196 0.527947
+CCAATG 62.129008 0.963085 1.082584 0.431095
+CCAATT 62.569248 0.930022 1.239671 0.528251
+CCACAA 68.147542 1.402922 0.962381 0.361327
+CCACAC 66.843727 1.110758 0.878114 0.314925
+CCACAG 67.487808 1.478896 0.997668 0.381382
+CCACAT 68.131461 1.349492 1.014987 0.391355
+CCACCA 63.553716 1.185022 0.842774 0.296106
+CCACCC 62.365266 1.324102 0.784972 0.266172
+CCACCG 63.180718 1.371778 0.862743 0.306692
+CCACCT 63.440746 1.303018 0.833873 0.291427
+CCACGA 67.619638 1.569311 0.921413 0.338503
+CCACGC 66.337677 1.105307 0.918102 0.33668
+CCACGG 66.64039 1.462074 0.937698 0.347516
+CCACGT 67.037138 1.152718 1.06759 0.42217
+CCACTA 64.973662 1.072669 0.851793 0.300872
+CCACTC 63.928274 0.814569 0.900666 0.327135
+CCACTG 64.459749 1.028363 0.953656 0.356425
+CCACTT 64.779847 0.921676 1.168425 0.483372
+CCAGAA 65.651652 1.070001 1.022712 0.395832
+CCAGAC 62.165976 1.104293 1.081739 0.430591
+CCAGAG 64.64052 1.093197 1.047899 0.410544
+CCAGAT 64.37353 1.016287 1.110817 0.448068
+CCAGCA 59.52398 1.212444 1.313351 0.576039
+CCAGCC 58.025096 1.057201 1.244916 0.531607
+CCAGCG 59.352556 1.196352 1.30112 0.568011
+CCAGCT 59.631532 1.093369 1.216984 0.513817
+CCAGGA 65.104436 0.883576 0.96966 0.365435
+CCAGGC 62.82023 1.324067 1.160194 0.478274
+CCAGGG 64.664187 0.962074 0.941614 0.349695
+CCAGGT 64.794301 0.861562 1.015343 0.391561
+CCAGTA 60.977978 1.833881 1.419883 0.647529
+CCAGTC 58.831886 2.197355 1.727841 0.869233
+CCAGTG 61.070679 1.847667 1.368082 0.612419
+CCAGTT 60.791532 2.157124 1.619475 0.788755
+CCATAA 59.815805 1.057575 1.038251 0.404888
+CCATAC 57.773495 0.996921 1.034378 0.402624
+CCATAG 59.647003 1.161757 1.097932 0.440295
+CCATAT 59.018771 0.912485 1.047456 0.410284
+CCATCA 54.325181 1.422268 1.477089 0.687054
+CCATCC 53.058309 1.30066 1.449148 0.667651
+CCATCG 54.21671 1.367291 1.400008 0.633981
+CCATCT 53.951791 1.261181 1.365192 0.61048
+CCATGA 57.762018 1.644366 1.231443 0.523
+CCATGC 55.544698 2.002936 1.512014 0.711565
+CCATGG 57.281757 1.771637 1.134882 0.462708
+CCATGT 56.31142 1.557493 1.268637 0.546873
+CCATTA 53.190038 2.012171 1.678639 0.83237
+CCATTC 50.491014 2.197355 2.058599 1.130416
+CCATTG 52.973773 2.083978 1.629056 0.795764
+CCATTT 51.895991 2.197355 1.776448 0.90617
+CCCAAA 67.895992 0.953845 1.025446 0.39742
+CCCAAC 64.797338 1.169177 1.144108 0.468362
+CCCAAG 67.508188 0.723893 1.035457 0.403254
+CCCAAT 67.284922 0.91417 1.21603 0.513212
+CCCACA 64.20982 0.728051 0.965528 0.363101
+CCCACC 62.919667 0.884501 0.913641 0.334229
+CCCACG 63.941886 0.710242 0.922469 0.339085
+CCCACT 64.192062 0.721435 0.938451 0.347935
+CCCAGA 70.88645 0.741676 1.007873 0.387248
+CCCAGC 68.982395 1.001076 1.085508 0.432843
+CCCAGG 70.203009 0.711658 1.0106 0.388821
+CCCAGT 70.485844 0.798656 1.352106 0.601723
+CCCATA 67.973811 0.858467 1.044538 0.408571
+CCCATC 66.514568 1.106037 1.189213 0.496329
+CCCATG 67.61122 0.888726 1.197108 0.501281
+CCCATT 67.939646 1.071751 1.422273 0.649165
+CCCCAA 70.479837 1.130413 0.917548 0.336375
+CCCCAC 68.93034 1.015894 0.827063 0.287865
+CCCCAG 70.455092 1.354684 0.935643 0.346375
+CCCCAT 70.543226 1.013867 0.977565 0.369913
+CCCCCA 67.156965 1.0679 0.758826 0.252985
+CCCCCC 65.796612 0.976375 0.684301 0.216646
+CCCCCG 66.871886 0.99991 0.691371 0.220013
+CCCCCT 67.026781 0.950265 0.766897 0.257031
+CCCCGA 70.838864 1.403373 0.893878 0.323443
+CCCCGC 69.268421 1.156882 0.8574 0.303848
+CCCCGG 70.048109 1.280761 0.938147 0.347766
+CCCCGT 70.130609 1.164912 1.101553 0.442475
+CCCCTA 68.424688 0.868656 0.841843 0.295615
+CCCCTC 67.167238 0.769099 0.896143 0.324673
+CCCCTG 67.82796 0.908394 1.030024 0.400085
+CCCCTT 67.821602 0.943551 1.331154 0.587791
+CCCGAA 70.530595 0.939325 0.899331 0.326408
+CCCGAC 67.776371 0.96144 0.995432 0.3801
+CCCGAG 70.215345 0.849723 0.936541 0.346873
+CCCGAT 69.861121 0.791188 0.996595 0.380767
+CCCGCA 65.034685 0.795226 0.909427 0.331919
+CCCGCC 63.742256 0.671215 0.811519 0.279788
+CCCGCG 64.926676 0.773893 0.910222 0.332355
+CCCGCT 65.10732 0.719129 0.879904 0.315888
+CCCGGA 69.22645 0.869207 0.985691 0.374534
+CCCGGC 67.222666 1.370725 1.28844 0.559728
+CCCGGG 68.804458 0.844446 1.012716 0.390043
+CCCGGT 69.006461 0.832269 1.331151 0.587789
+CCCGTA 64.242804 2.197355 1.539769 0.731247
+CCCGTC 61.301604 2.197355 1.990503 1.074793
+CCCGTG 64.084834 2.012974 1.611066 0.78262
+CCCGTT 63.518597 2.197355 1.905395 1.006603
+CCCTAA 63.762066 0.78886 0.737331 0.242311
+CCCTAC 61.683505 0.695563 0.780722 0.264013
+CCCTAG 63.199716 0.883732 0.804747 0.276293
+CCCTAT 62.875991 0.712222 0.832154 0.290527
+CCCTCA 58.945419 0.94541 1.023756 0.396438
+CCCTCC 57.694674 0.870059 1.073423 0.425634
+CCCTCG 58.828946 0.932645 1.053454 0.413813
+CCCTCT 58.619303 0.919018 0.993156 0.378797
+CCCTGA 60.289949 1.360263 1.118444 0.452691
+CCCTGC 57.772268 2.055734 1.514143 0.713068
+CCCTGG 60.165808 1.420969 0.97889 0.370665
+CCCTGT 59.240086 1.473661 1.18719 0.495064
+CCCTTA 55.917218 2.041227 1.510121 0.710229
+CCCTTC 53.468363 2.197355 1.786372 0.913774
+CCCTTG 56.402928 1.807523 1.329363 0.586605
+CCCTTT 54.697868 2.029487 1.53185 0.725613
+CCGAAA 72.760149 1.18258 1.202685 0.504787
+CCGAAC 69.580723 1.062379 1.158706 0.477354
+CCGAAG 72.309803 1.173531 1.196123 0.500662
+CCGAAT 72.432097 1.068217 1.416901 0.645491
+CCGACA 62.365739 0.826914 0.898806 0.326122
+CCGACC 61.051818 0.896507 1.003638 0.38481
+CCGACG 62.176282 0.87783 0.905888 0.329983
+CCGACT 62.649493 0.775524 0.952217 0.355618
+CCGAGA 72.080214 1.20131 1.250943 0.535472
+CCGAGC 68.665237 1.425264 1.244294 0.531209
+CCGAGG 71.140975 1.239618 1.195502 0.500272
+CCGAGT 71.22013 0.909555 1.417311 0.645771
+CCGATA 65.260976 1.394673 1.190382 0.497062
+CCGATC 63.668269 1.857487 1.515785 0.714229
+CCGATG 65.12683 1.479068 1.272337 0.549267
+CCGATT 65.57521 1.696009 1.543011 0.733558
+CCGCAA 72.006588 1.606916 1.279854 0.554142
+CCGCAC 70.550551 1.422057 1.109106 0.447034
+CCGCAG 71.73009 1.588789 1.172091 0.485649
+CCGCAT 71.859115 1.658614 1.351782 0.601507
+CCGCCA 66.18496 1.34556 0.792976 0.270253
+CCGCCC 65.484302 1.099304 0.784799 0.266084
+CCGCCG 66.056963 1.279436 0.789377 0.268416
+CCGCCT 66.518635 1.114074 0.857547 0.303926
+CCGCGA 71.944161 1.668927 1.169241 0.483879
+CCGCGC 69.854419 1.480974 1.11443 0.450256
+CCGCGG 70.984934 1.383549 1.212747 0.511136
+CCGCGT 70.429174 1.586326 1.482379 0.690748
+CCGCTA 68.540717 1.173096 1.071469 0.424473
+CCGCTC 67.325598 0.973617 1.096624 0.439509
+CCGCTG 67.967044 1.125368 1.146654 0.469926
+CCGCTT 68.308627 1.155783 1.41318 0.64295
+CCGGAA 62.784648 1.367618 1.31233 0.575367
+CCGGAC 58.369026 1.144688 1.33495 0.590308
+CCGGAG 61.791459 1.337896 1.33873 0.592816
+CCGGAT 61.561983 1.16266 1.379805 0.620308
+CCGGCA 55.647022 1.412598 1.71191 0.857239
+CCGGCC 54.533254 1.598898 1.642899 0.805929
+CCGGCG 55.471657 1.509399 1.734772 0.874469
+CCGGCT 55.84695 1.384642 1.60315 0.776858
+CCGGGA 60.20791 1.527442 1.493042 0.698214
+CCGGGC 56.795903 2.197355 1.561534 0.746806
+CCGGGG 59.43865 1.718611 1.354483 0.60331
+CCGGGT 59.586596 1.535888 1.447736 0.666676
+CCGGTA 56.154511 2.197355 1.687806 0.839198
+CCGGTC 53.516894 2.197355 2.027518 1.104912
+CCGGTG 56.175745 2.096219 1.633169 0.79878
+CCGGTT 55.667873 2.197355 1.854022 0.966169
+CCGTAA 48.07341 2.132727 1.990097 1.074465
+CCGTAC 46.657136 1.709124 1.922636 1.020296
+CCGTAG 47.439719 2.053949 1.86001 0.970853
+CCGTAT 47.163312 1.597629 1.672041 0.827468
+CCGTCA 41.842216 2.197355 2.218684 1.264806
+CCGTCC 40.491236 1.81415 2.148163 1.204985
+CCGTCG 41.414913 1.945735 2.109174 1.172328
+CCGTCT 41.272245 1.807976 1.928831 1.025232
+CCGTGA 46.356936 1.682491 1.86745 0.976684
+CCGTGC 44.621306 1.370201 1.749257 0.885444
+CCGTGG 45.629056 1.768078 1.824027 0.942818
+CCGTGT 45.471556 1.465512 1.65008 0.811219
+CCGTTA 41.999517 1.518701 1.827264 0.945328
+CCGTTC 40.254173 1.262995 1.650887 0.811815
+CCGTTG 41.748076 1.433983 1.724483 0.8667
+CCGTTT 41.27423 1.442696 1.58844 0.76619
+CCTAAA 67.764211 0.977179 0.838933 0.294084
+CCTAAC 65.589107 0.692594 0.850888 0.300393
+CCTAAG 67.908601 1.006882 0.881602 0.316803
+CCTAAT 67.600757 0.907604 0.915102 0.335031
+CCTACA 62.225477 1.079508 0.73588 0.241597
+CCTACC 61.071781 0.879074 0.666515 0.208255
+CCTACG 61.853345 1.055615 0.71393 0.230868
+CCTACT 62.323959 1.148522 0.765151 0.256154
+CCTAGA 68.372641 0.843961 0.896164 0.324685
+CCTAGC 66.244113 1.163422 1.034435 0.402657
+CCTAGG 67.51285 0.534015 1.010025 0.388489
+CCTAGT 67.392195 0.887114 0.869079 0.310077
+CCTATA 63.900658 0.764163 0.847324 0.298507
+CCTATC 62.761078 0.704991 0.907596 0.330917
+CCTATG 63.779502 0.73871 0.926781 0.341465
+CCTATT 64.12642 0.76719 1.12731 0.458084
+CCTCAA 65.215877 2.017877 1.046725 0.409854
+CCTCAC 64.958051 1.54058 0.915493 0.335246
+CCTCAG 65.431219 1.8729 1.106648 0.445549
+CCTCAT 64.856238 2.197355 1.119134 0.45311
+CCTCCA 61.327038 1.435515 0.97004 0.365649
+CCTCCC 60.787041 1.259337 0.872405 0.311859
+CCTCCG 60.815361 1.446637 0.929822 0.343147
+CCTCCT 61.124348 1.528695 0.907601 0.33092
+CCTCGA 65.118499 2.179845 1.065085 0.420685
+CCTCGC 64.456522 1.54406 0.950903 0.354883
+CCTCGG 64.384219 1.71588 1.107219 0.445893
+CCTCGT 65.052903 1.6883 1.207233 0.507654
+CCTCTA 63.025873 1.162123 0.819224 0.283782
+CCTCTC 61.256909 1.045809 0.851075 0.300492
+CCTCTG 62.056512 1.210001 0.921373 0.338481
+CCTCTT 62.059716 1.274882 1.184221 0.493208
+CCTGAA 57.062811 1.247567 1.153143 0.473921
+CCTGAC 53.563501 0.928779 1.118124 0.452497
+CCTGAG 56.294331 1.14266 1.12169 0.454663
+CCTGAT 55.461847 1.202317 1.183426 0.492711
+CCTGCA 50.899031 1.131318 1.421612 0.648712
+CCTGCC 49.501318 1.044107 1.352135 0.601742
+CCTGCG 50.565667 1.127033 1.44768 0.666637
+CCTGCT 50.761516 1.122871 1.319838 0.580312
+CCTGGA 57.529315 1.100457 1.038169 0.404839
+CCTGGC 55.94036 0.729941 0.931232 0.343928
+CCTGGG 56.835113 1.017205 0.892986 0.322959
+CCTGGT 57.332452 0.971505 0.915764 0.335394
+CCTGTA 54.104335 0.74217 0.946816 0.352598
+CCTGTC 52.343136 1.072505 1.28365 0.556609
+CCTGTG 53.824919 0.699206 0.917417 0.336303
+CCTGTT 54.060793 0.721003 1.062105 0.418921
+CCTTAA 50.625532 1.081759 1.154983 0.475055
+CCTTAC 49.624178 0.87225 1.125008 0.456682
+CCTTAG 50.286797 0.948607 1.027591 0.398668
+CCTTAT 50.255243 0.812132 1.045356 0.409051
+CCTTCA 44.625766 1.071905 1.635704 0.800641
+CCTTCC 43.54748 1.123768 1.502711 0.705008
+CCTTCG 44.298156 1.029624 1.522958 0.719304
+CCTTCT 44.203391 0.959717 1.346519 0.597998
+CCTTGA 49.475902 0.939744 1.186741 0.494783
+CCTTGC 48.330425 0.673739 1.003698 0.384844
+CCTTGG 48.810639 0.816114 1.064606 0.420401
+CCTTGT 48.890705 0.809246 0.990397 0.37722
+CCTTTA 45.067284 0.853175 1.134872 0.462701
+CCTTTC 43.267356 0.66626 1.025178 0.397264
+CCTTTG 44.613616 0.713191 1.059794 0.417554
+CCTTTT 44.310888 0.710965 0.979566 0.371049
+CGAAAA 66.785757 1.136386 1.01616 0.392034
+CGAAAC 64.484293 1.425845 1.326883 0.584965
+CGAAAG 66.401239 1.115211 1.016138 0.392021
+CGAAAT 66.430239 1.247445 1.315226 0.577273
+CGAACA 58.291065 1.45916 1.317793 0.578964
+CGAACC 57.435976 1.653901 1.401162 0.634765
+CGAACG 58.160267 1.509836 1.31885 0.57966
+CGAACT 58.774735 1.663818 1.200049 0.503129
+CGAAGA 67.015487 1.184165 1.087443 0.434001
+CGAAGC 65.867162 1.63623 1.410461 0.641095
+CGAAGG 66.537521 1.215142 1.035354 0.403194
+CGAAGT 66.861215 1.255154 1.372544 0.615418
+CGAATA 61.94884 1.662696 1.424872 0.650945
+CGAATC 61.163728 2.197355 1.593514 0.769864
+CGAATG 61.776316 1.823215 1.392511 0.628896
+CGAATT 62.828232 2.006072 1.602663 0.776504
+CGACAA 64.187572 1.225574 0.791737 0.26962
+CGACAC 63.509458 0.82629 0.741413 0.244327
+CGACAG 63.929563 1.08303 0.821051 0.284732
+CGACAT 64.193269 1.160509 0.850288 0.300075
+CGACCA 58.994526 0.764134 0.881878 0.316952
+CGACCC 58.072538 0.764301 0.880769 0.316354
+CGACCG 58.720921 0.718981 0.889073 0.320839
+CGACCT 58.811483 0.753957 0.823785 0.286155
+CGACGA 63.613123 1.236537 0.815046 0.281614
+CGACGC 62.70073 0.930606 0.795932 0.271765
+CGACGG 62.863789 1.213289 0.820546 0.284469
+CGACGT 62.844187 1.209354 0.906821 0.330494
+CGACTA 61.017002 0.739455 0.769822 0.258503
+CGACTC 60.153127 0.687082 0.9038 0.328843
+CGACTG 60.503027 0.680461 0.794983 0.27128
+CGACTT 60.82367 0.680138 1.066286 0.421397
+CGAGAA 65.56989 1.18605 1.10516 0.44465
+CGAGAC 62.845537 1.062075 1.152569 0.473567
+CGAGAG 64.955554 1.24685 1.186873 0.494866
+CGAGAT 64.998292 1.107145 1.20052 0.503425
+CGAGCA 58.703526 1.40088 1.485742 0.693099
+CGAGCC 57.820241 1.25853 1.421666 0.64875
+CGAGCG 58.514218 1.343182 1.403412 0.636295
+CGAGCT 58.86055 1.24583 1.394067 0.62995
+CGAGGA 64.388833 1.113184 1.128764 0.458971
+CGAGGC 63.383247 1.475903 1.248246 0.533742
+CGAGGG 63.695226 1.042565 1.075281 0.42674
+CGAGGT 64.415956 1.130051 1.206166 0.50698
+CGAGTA 60.550109 1.521335 1.474903 0.685529
+CGAGTC 58.782253 2.197355 1.753488 0.888658
+CGAGTG 60.349618 1.642257 1.435113 0.657975
+CGAGTT 60.332518 1.763641 1.656787 0.81617
+CGATAA 55.938921 1.340084 1.275256 0.551158
+CGATAC 54.420213 1.122178 1.265116 0.544598
+CGATAG 55.577576 1.357442 1.216396 0.513444
+CGATAT 55.372805 1.204476 1.220774 0.516218
+CGATCA 49.983626 1.544053 1.746417 0.883289
+CGATCC 48.847467 1.466975 1.661872 0.81993
+CGATCG 49.855345 1.577987 1.638169 0.802452
+CGATCT 49.660702 1.478869 1.548206 0.737265
+CGATGA 54.259077 1.274336 1.254174 0.537548
+CGATGC 52.919972 1.691083 1.590402 0.767611
+CGATGG 53.479339 1.241943 1.2709 0.548337
+CGATGT 53.185642 1.373173 1.270909 0.548343
+CGATTA 49.370845 1.554404 1.537711 0.729781
+CGATTC 47.949168 2.014423 1.958928 1.049321
+CGATTG 49.5117 1.856448 1.540704 0.731913
+CGATTT 49.021757 1.836404 1.79471 0.920178
+CGCAAA 67.23651 1.356302 1.151919 0.473166
+CGCAAC 64.552429 1.764847 1.376195 0.617875
+CGCAAG 66.852572 1.244712 1.076228 0.427304
+CGCAAT 66.431752 1.199098 1.37199 0.615045
+CGCACA 63.141882 1.044613 1.109286 0.447142
+CGCACC 62.125241 1.402329 1.117418 0.452068
+CGCACG 62.761808 1.055207 1.126054 0.45732
+CGCACT 63.124328 1.183239 1.058325 0.416686
+CGCAGA 69.077294 1.109552 1.094867 0.438453
+CGCAGC 67.759864 1.737329 1.338528 0.592682
+CGCAGG 68.470684 1.025989 1.061656 0.418655
+CGCAGT 68.817673 1.357617 1.476882 0.686909
+CGCATA 65.861764 1.379882 1.182461 0.492109
+CGCATC 64.93097 2.058185 1.443732 0.663912
+CGCATG 65.883258 1.409595 1.302036 0.568611
+CGCATT 65.994283 1.615142 1.603447 0.777074
+CGCCAA 67.588914 0.872759 0.82203 0.285241
+CGCCAC 66.592854 0.696154 0.761278 0.254212
+CGCCAG 67.251525 0.982431 0.831352 0.290107
+CGCCAT 67.766273 0.939424 0.895212 0.324167
+CGCCCA 64.198334 0.777469 0.774885 0.261058
+CGCCCC 63.322599 0.648284 0.72882 0.238128
+CGCCCG 63.927309 0.685955 0.751347 0.249254
+CGCCCT 64.03333 0.791078 0.777234 0.262246
+CGCCGA 67.625582 1.026746 0.768132 0.257653
+CGCCGC 66.697616 0.758492 0.771406 0.259302
+CGCCGG 66.821016 0.935363 0.850864 0.30038
+CGCCGT 67.09221 0.931776 1.006345 0.386368
+CGCCTA 65.450767 0.621503 0.755536 0.251341
+CGCCTC 64.346652 1.034802 0.945956 0.352117
+CGCCTG 65.063841 0.678169 0.921091 0.338325
+CGCCTT 65.156809 0.810628 1.264332 0.544092
+CGCGAA 68.988412 1.011839 1.002269 0.384023
+CGCGAC 66.882958 1.253823 1.116506 0.451515
+CGCGAG 68.59374 1.024082 1.065415 0.42088
+CGCGAT 68.637494 0.933625 1.148288 0.470931
+CGCGCA 63.654058 1.093582 1.142177 0.467176
+CGCGCC 62.481043 0.90254 0.988136 0.375929
+CGCGCG 63.342178 1.078129 1.088689 0.434747
+CGCGCT 63.744894 0.873291 1.090905 0.436075
+CGCGGA 67.138238 1.023865 1.068979 0.422994
+CGCGGC 65.361816 1.960207 1.542605 0.733268
+CGCGGG 66.768765 1.12299 1.144836 0.468809
+CGCGGT 66.953513 1.211948 1.505948 0.707287
+CGCGTA 61.776118 2.197355 1.793451 0.919211
+CGCGTC 60.115728 2.197355 2.148815 1.205533
+CGCGTG 61.736935 2.197355 1.826676 0.944872
+CGCGTT 61.206733 2.197355 2.090851 1.157085
+CGCTAA 61.199237 1.135034 1.019703 0.394086
+CGCTAC 59.548689 1.236437 1.055547 0.415047
+CGCTAG 60.890342 1.124068 1.024387 0.396804
+CGCTAT 60.489569 1.011634 1.035886 0.403505
+CGCTCA 56.273842 1.366016 1.392535 0.628912
+CGCTCC 55.178562 1.347956 1.335567 0.590717
+CGCTCG 56.110164 1.373647 1.331527 0.588038
+CGCTCT 55.825344 1.25009 1.220422 0.515995
+CGCTGA 58.455726 1.942462 1.273679 0.550137
+CGCTGC 56.579343 2.197355 1.642827 0.805876
+CGCTGG 57.882247 1.855063 1.173346 0.486429
+CGCTGT 57.368371 1.738146 1.336931 0.591622
+CGCTTA 54.517995 2.197355 1.625349 0.79305
+CGCTTC 51.908323 2.197355 2.033766 1.110023
+CGCTTG 54.323045 2.197355 1.560031 0.745728
+CGCTTT 53.035209 2.197355 1.852625 0.965077
+CGGAAA 75.705443 1.676123 1.770078 0.9013
+CGGAAC 72.462079 1.349774 1.678647 0.832377
+CGGAAG 75.260397 1.651853 1.724134 0.866437
+CGGAAT 75.325671 1.721678 2.004543 1.086185
+CGGACA 62.45184 1.008498 1.088648 0.434722
+CGGACC 61.412006 0.874745 1.155069 0.475108
+CGGACG 61.682262 1.585645 1.087316 0.433924
+CGGACT 63.14633 1.017447 1.246153 0.5324
+CGGAGA 74.037263 1.775489 1.771998 0.902767
+CGGAGC 71.5675 1.347882 1.644552 0.807146
+CGGAGG 73.048034 1.737954 1.730332 0.871114
+CGGAGT 73.596044 1.700847 2.023796 1.101871
+CGGATA 67.184762 1.28468 1.612176 0.783428
+CGGATC 66.19661 1.362176 1.841886 0.956697
+CGGATG 66.977681 1.359659 1.641205 0.804683
+CGGATT 68.314967 1.421411 1.901673 1.003655
+CGGCAA 72.071463 2.11237 1.751009 0.886774
+CGGCAC 70.896125 1.832246 1.633626 0.799115
+CGGCAG 71.24636 2.197355 1.639158 0.803178
+CGGCAT 71.847264 2.017698 1.783584 0.911635
+CGGCCA 64.451622 2.197355 1.356078 0.604376
+CGGCCC 64.151931 1.660685 1.194299 0.499517
+CGGCCG 64.484598 1.794323 1.211315 0.51023
+CGGCCT 64.709831 2.197355 1.237341 0.526763
+CGGCGA 71.725718 2.197355 1.632999 0.798655
+CGGCGC 70.06952 1.974851 1.574325 0.756001
+CGGCGG 70.54183 2.168886 1.678182 0.83203
+CGGCGT 70.255207 2.140593 1.822776 0.941847
+CGGCTA 68.172771 1.82596 1.510968 0.710826
+CGGCTC 67.152381 1.733103 1.578286 0.758856
+CGGCTG 67.533239 1.683186 1.589395 0.766882
+CGGCTT 68.044035 1.998077 1.898176 1.000888
+CGGGAA 66.612695 1.957933 1.566847 0.750621
+CGGGAC 62.870037 1.401643 1.289561 0.560459
+CGGGAG 65.264803 1.912729 1.537988 0.729979
+CGGGAT 65.66529 1.640448 1.64788 0.809597
+CGGGCA 56.920478 1.326645 1.502395 0.704785
+CGGGCC 55.741825 1.218338 1.406683 0.638521
+CGGGCG 56.881567 1.455185 1.497663 0.701458
+CGGGCT 57.658511 1.458294 1.471563 0.683202
+CGGGGA 64.603651 1.622039 1.43587 0.658496
+CGGGGC 61.805664 1.462703 1.318881 0.579681
+CGGGGG 63.710548 1.707724 1.406477 0.63838
+CGGGGT 64.202638 1.708492 1.598014 0.773128
+CGGGTA 60.96419 1.445135 1.447434 0.666467
+CGGGTC 59.185803 2.197355 1.619327 0.788647
+CGGGTG 61.019248 1.484814 1.410804 0.641329
+CGGGTT 61.58262 1.414232 1.657117 0.816414
+CGGTAA 51.128306 1.476948 1.420753 0.648125
+CGGTAC 50.131343 1.532735 1.454622 0.671438
+CGGTAG 50.677626 1.635643 1.492241 0.697653
+CGGTAT 50.851301 1.337214 1.362201 0.608475
+CGGTCA 44.137839 1.662288 1.82086 0.940363
+CGGTCC 43.354048 1.724871 1.908499 1.009064
+CGGTCG 44.183329 1.797862 1.808947 0.93115
+CGGTCT 43.933829 1.582146 1.634404 0.799686
+CGGTGA 50.243922 1.618172 1.499775 0.702943
+CGGTGC 49.108966 1.443834 1.347273 0.5985
+CGGTGG 49.407311 1.52707 1.453165 0.670429
+CGGTGT 49.484341 1.390336 1.338848 0.592895
+CGGTTA 45.041134 1.345568 1.476307 0.686508
+CGGTTC 43.697712 1.522909 1.486527 0.693649
+CGGTTG 44.76715 1.451006 1.412162 0.642255
+CGGTTT 44.615802 1.613077 1.382225 0.62194
+CGTAAA 61.894278 2.03192 1.635956 0.800826
+CGTAAC 60.578232 1.353311 1.277808 0.552814
+CGTAAG 61.994377 1.89308 1.604804 0.778061
+CGTAAT 62.115401 2.197355 1.485202 0.692722
+CGTACA 56.707365 1.952815 1.545819 0.735561
+CGTACC 55.690403 1.817298 1.338352 0.592565
+CGTACG 56.399839 2.06239 1.39047 0.627514
+CGTACT 56.85343 1.960023 1.476034 0.686318
+CGTAGA 61.813317 1.905744 1.761153 0.894491
+CGTAGC 60.774706 1.591932 1.388447 0.626145
+CGTAGG 60.586692 2.197355 1.562863 0.74776
+CGTAGT 61.691615 2.197355 1.607653 0.780134
+CGTATA 58.518017 1.793641 1.340785 0.594182
+CGTATC 57.552783 1.290261 1.34434 0.596546
+CGTATG 58.513108 1.478223 1.394127 0.629991
+CGTATT 58.73128 1.436789 1.542493 0.733188
+CGTCAA 56.953929 2.197355 1.876013 0.983409
+CGTCAC 55.752616 2.197355 1.789924 0.9165
+CGTCAG 56.49809 2.197355 2.012899 1.092983
+CGTCAT 57.336915 2.197355 1.962034 1.051818
+CGTCCA 52.858681 2.197355 1.830116 0.947542
+CGTCCC 51.625635 2.197355 1.656958 0.816296
+CGTCCG 52.456081 2.197355 1.871755 0.980063
+CGTCCT 52.453412 2.197355 1.843103 0.957646
+CGTCGA 56.849775 2.197355 2.030541 1.107384
+CGTCGC 55.213346 2.197355 1.816668 0.937117
+CGTCGG 55.62097 2.197355 1.893761 0.997398
+CGTCGT 55.655863 2.197355 2.070657 1.140363
+CGTCTA 54.198019 2.197355 1.654566 0.814529
+CGTCTC 53.293447 2.197355 1.515784 0.714227
+CGTCTG 52.604612 2.197355 1.537824 0.729862
+CGTCTT 54.147014 2.197355 1.572192 0.754465
+CGTGAA 54.995372 2.056195 1.719258 0.862764
+CGTGAC 52.306832 1.353499 1.186545 0.49466
+CGTGAG 53.833453 1.741608 1.544848 0.734868
+CGTGAT 54.048545 1.793256 1.490163 0.696196
+CGTGCA 49.188254 1.739787 1.678663 0.832388
+CGTGCC 47.967045 1.581867 1.424633 0.650781
+CGTGCG 49.079024 1.520439 1.61491 0.785422
+CGTGCT 49.295714 1.819629 1.463539 0.677621
+CGTGGA 54.838166 1.934383 1.683074 0.835671
+CGTGGC 53.485278 1.459948 1.268801 0.546979
+CGTGGG 54.320231 1.732698 1.440543 0.661713
+CGTGGT 55.075493 1.810444 1.455239 0.671865
+CGTGTA 51.822199 1.141281 1.165782 0.481733
+CGTGTC 50.177397 0.852259 1.16814 0.483196
+CGTGTG 51.578676 1.160558 1.094994 0.438529
+CGTGTT 51.579023 1.116504 1.185448 0.493974
+CGTTAA 48.419073 1.46594 1.370559 0.614083
+CGTTAC 47.310886 1.102671 1.247685 0.533381
+CGTTAG 47.939227 1.334042 1.297249 0.565478
+CGTTAT 48.016 1.200247 1.227805 0.520685
+CGTTCA 42.801289 1.066185 1.5391 0.730771
+CGTTCC 41.783156 0.884701 1.406309 0.638266
+CGTTCG 42.502644 1.031017 1.445948 0.665441
+CGTTCT 42.422853 0.938693 1.301046 0.567962
+CGTTGA 47.305013 1.302643 1.310014 0.573845
+CGTTGC 46.319564 0.822816 1.059404 0.417323
+CGTTGG 46.64177 1.103017 1.185612 0.494077
+CGTTGT 46.66804 1.061861 1.067481 0.422106
+CGTTTA 43.340296 0.892224 1.18895 0.496165
+CGTTTC 41.890878 0.645387 0.988177 0.375952
+CGTTTG 42.933143 0.770281 1.035808 0.403459
+CGTTTT 42.692106 0.639839 0.932544 0.344655
+CTAAAA 66.434835 0.788174 0.830028 0.289414
+CTAAAC 63.673819 0.750877 1.019901 0.394201
+CTAAAG 65.873146 0.829917 0.854822 0.302478
+CTAAAT 65.70251 0.753414 0.954845 0.357092
+CTAACA 59.099843 0.841099 0.871338 0.311287
+CTAACC 58.028046 0.91682 0.91473 0.334827
+CTAACG 58.886617 0.764592 0.89588 0.32453
+CTAACT 59.218958 0.704233 0.860633 0.305568
+CTAAGA 67.910685 0.903975 0.915212 0.335091
+CTAAGC 66.304191 0.925205 1.098685 0.440748
+CTAAGG 66.758712 1.013847 0.89537 0.324253
+CTAAGT 67.476626 1.022507 1.059328 0.417279
+CTAATA 63.423031 0.916867 0.980514 0.371588
+CTAATC 62.456962 1.159607 1.135703 0.46321
+CTAATG 63.216533 0.941505 1.037667 0.404546
+CTAATT 63.744559 0.95312 1.327155 0.585144
+CTACAA 67.484234 1.253208 0.874439 0.31295
+CTACAC 66.487479 1.006015 0.804865 0.276354
+CTACAG 67.042324 1.132712 0.869049 0.310061
+CTACAT 67.469856 1.253581 0.942028 0.349926
+CTACCA 62.571435 0.862023 0.731112 0.239253
+CTACCC 61.692488 0.846247 0.693161 0.220868
+CTACCG 62.283562 0.804111 0.726743 0.237111
+CTACCT 62.451698 0.868051 0.669384 0.209601
+CTACGA 67.153773 1.349955 0.869373 0.310234
+CTACGC 65.994993 0.991785 0.858747 0.304564
+CTACGG 66.276114 1.111913 0.864069 0.3074
+CTACGT 66.506698 1.001946 0.917913 0.336576
+CTACTA 64.5314 0.838929 0.790863 0.269174
+CTACTC 63.823089 0.729961 0.85151 0.300722
+CTACTG 64.042902 0.901413 0.862283 0.306447
+CTACTT 64.327173 0.859016 1.129882 0.459653
+CTAGAA 65.98137 0.666979 0.90387 0.328882
+CTAGAC 62.978137 1.698584 0.888062 0.320291
+CTAGAG 65.202761 0.987505 0.870547 0.310863
+CTAGAT 65.513332 0.793952 0.999191 0.382255
+CTAGCA 59.826087 0.771262 1.072283 0.424957
+CTAGCC 58.747262 0.903216 1.05957 0.417422
+CTAGCG 59.785087 0.951995 1.159591 0.477901
+CTAGCT 60.461316 1.035129 1.20002 0.50311
+CTAGGA 66.176467 1.447136 0.910573 0.332547
+CTAGGC 64.033445 0.796157 0.891104 0.321939
+CTAGGG 64.800024 0.906726 0.905154 0.329582
+CTAGGT 66.257025 0.820803 1.036717 0.40399
+CTAGTA 62.517815 1.007207 1.067744 0.422261
+CTAGTC 60.141754 1.481059 1.147855 0.470665
+CTAGTG 62.109576 1.193 1.037994 0.404737
+CTAGTT 62.47989 1.138128 1.275637 0.551406
+CTATAA 59.358844 0.949733 0.866145 0.308508
+CTATAC 57.536073 0.686053 0.811523 0.27979
+CTATAG 59.058497 0.960637 0.870678 0.310933
+CTATAT 58.564361 0.708075 0.856952 0.30361
+CTATCA 53.507198 1.162543 1.294557 0.563719
+CTATCC 52.084822 0.999753 1.229856 0.52199
+CTATCG 53.391168 1.197142 1.250208 0.535
+CTATCT 52.882399 1.050457 1.111285 0.448352
+CTATGA 57.725281 1.080899 0.91589 0.335464
+CTATGC 55.534167 1.371637 1.249257 0.53439
+CTATGG 57.048809 1.226694 0.856786 0.303521
+CTATGT 56.432063 1.058432 0.997126 0.381071
+CTATTA 53.133549 1.226541 1.319112 0.579833
+CTATTC 51.092246 1.73295 1.55138 0.739533
+CTATTG 52.891976 1.396245 1.236308 0.526103
+CTATTT 52.564578 1.566764 1.325458 0.584023
+CTCAAA 66.796834 0.679826 0.986251 0.374854
+CTCAAC 64.345415 0.911977 1.099475 0.441223
+CTCAAG 66.36484 0.664587 0.971173 0.36629
+CTCAAT 66.27078 0.728522 1.102853 0.443258
+CTCACA 63.118349 0.701678 0.889249 0.320934
+CTCACC 61.88672 0.872368 0.851673 0.300808
+CTCACG 62.776676 0.687118 0.864796 0.307788
+CTCACT 63.225152 0.819249 0.860816 0.305665
+CTCAGA 69.127471 0.944383 1.005574 0.385924
+CTCAGC 67.824144 0.804927 1.087647 0.434123
+CTCAGG 68.579822 0.786506 0.924613 0.340268
+CTCAGT 68.851371 1.009718 1.312901 0.575743
+CTCATA 66.692487 0.740376 0.986647 0.37508
+CTCATC 65.815669 0.791734 1.181828 0.491713
+CTCATG 66.41691 0.739276 1.155476 0.475359
+CTCATT 66.912255 0.798817 1.422058 0.649018
+CTCCAA 68.03639 1.229465 0.985972 0.374695
+CTCCAC 66.334977 1.123029 0.898629 0.326025
+CTCCAG 67.049525 1.580011 1.081766 0.430606
+CTCCAT 67.446969 1.579336 1.1069 0.445701
+CTCCCA 64.090322 1.143303 0.847267 0.298477
+CTCCCC 62.993913 1.056878 0.760108 0.253626
+CTCCCG 63.703155 1.147125 0.840552 0.294936
+CTCCCT 63.903908 1.133605 0.813593 0.280861
+CTCCGA 67.33576 1.770332 1.055543 0.415044
+CTCCGC 66.63131 1.08466 0.97256 0.367075
+CTCCGG 66.667534 1.585009 1.093877 0.437858
+CTCCGT 67.554952 1.365388 1.113333 0.449592
+CTCCTA 65.621377 1.129069 0.866146 0.308509
+CTCCTC 64.561334 1.082645 0.930383 0.343457
+CTCCTG 65.064489 1.059242 0.985841 0.37462
+CTCCTT 65.170235 1.149961 1.21938 0.515335
+CTCGAA 68.448888 1.034812 0.90224 0.327992
+CTCGAC 66.429534 0.683309 0.904827 0.329404
+CTCGAG 68.103118 0.963626 0.931773 0.344227
+CTCGAT 68.187065 0.875222 1.023334 0.396193
+CTCGCA 63.356341 0.76407 0.902296 0.328023
+CTCGCC 62.46244 0.699918 0.787491 0.267454
+CTCGCG 63.298861 0.775606 0.898838 0.326139
+CTCGCT 63.621037 0.757308 0.907144 0.33067
+CTCGGA 67.433535 1.068871 0.968835 0.364969
+CTCGGC 66.1541 0.84994 1.112582 0.449137
+CTCGGG 66.938982 0.976854 0.947142 0.35278
+CTCGGT 67.25653 0.918314 1.183106 0.492511
+CTCGTA 64.579719 1.058742 1.169881 0.484276
+CTCGTC 62.167164 1.627021 1.486666 0.693746
+CTCGTG 64.310095 0.913893 1.203815 0.505499
+CTCGTT 64.31542 1.190542 1.398335 0.632845
+CTCTAA 62.022666 0.681499 0.719736 0.23369
+CTCTAC 60.215088 0.745194 0.722438 0.235008
+CTCTAG 61.448708 0.760714 0.771501 0.259349
+CTCTAT 61.273313 0.615325 0.730483 0.238944
+CTCTCA 57.231603 0.822602 0.91812 0.33669
+CTCTCC 56.147902 0.791694 0.835202 0.292124
+CTCTCG 57.134251 0.7935 0.930661 0.343612
+CTCTCT 56.700583 0.720936 0.80718 0.277547
+CTCTGA 59.61634 0.947419 0.921375 0.338482
+CTCTGC 57.230515 1.387654 1.163976 0.480615
+CTCTGG 59.177441 1.006265 0.824458 0.286506
+CTCTGT 58.569413 0.973521 0.910547 0.332533
+CTCTTA 55.621702 1.231165 1.087183 0.433845
+CTCTTC 53.548869 1.709293 1.371798 0.614916
+CTCTTG 55.482903 1.276173 0.972152 0.366844
+CTCTTT 54.876511 1.420255 1.115988 0.451201
+CTGAAA 73.348289 2.037435 1.896817 0.999813
+CTGAAC 69.922462 2.093771 1.805452 0.928452
+CTGAAG 73.096822 2.03825 1.865821 0.975407
+CTGAAT 72.742039 2.197355 2.026295 1.103912
+CTGACA 60.93065 1.661367 1.148637 0.471146
+CTGACC 60.463736 1.204326 1.03824 0.404881
+CTGACG 60.437857 1.700675 1.07545 0.426841
+CTGACT 62.100423 1.425292 1.108365 0.446586
+CTGAGA 72.025028 2.151748 1.883253 0.989108
+CTGAGC 68.538467 2.10804 1.719428 0.862892
+CTGAGG 71.204223 1.877614 1.770739 0.901805
+CTGAGT 71.115497 2.197355 2.055087 1.127524
+CTGATA 65.036461 2.051534 1.549219 0.737989
+CTGATC 64.54965 1.607549 1.517918 0.715736
+CTGATG 65.17461 1.856493 1.532278 0.725917
+CTGATT 66.403954 1.908259 1.824945 0.943529
+CTGCAA 71.056854 2.197355 2.036359 1.112147
+CTGCAC 69.684234 2.197355 1.966067 1.055063
+CTGCAG 70.085276 2.197355 1.972443 1.060199
+CTGCAT 70.960757 2.197355 2.084419 1.15175
+CTGCCA 63.279441 2.197355 1.563714 0.74837
+CTGCCC 62.794185 2.197355 1.386498 0.624826
+CTGCCG 62.697735 2.197355 1.511807 0.711419
+CTGCCT 63.565635 2.197355 1.511994 0.71155
+CTGCGA 70.343845 2.197355 1.966137 1.055119
+CTGCGC 68.252081 2.197355 1.879421 0.98609
+CTGCGG 68.533302 2.197355 1.939276 1.03357
+CTGCGT 69.46736 2.197355 2.062942 1.133995
+CTGCTA 67.18279 2.197355 1.679631 0.833108
+CTGCTC 65.640004 2.197355 1.789242 0.915976
+CTGCTG 66.283268 2.197355 1.810237 0.932146
+CTGCTT 66.284119 2.197355 2.073892 1.143035
+CTGGAA 64.892573 1.833917 1.386824 0.625047
+CTGGAC 61.50036 1.113164 0.98341 0.373235
+CTGGAG 64.422164 1.658288 1.363438 0.609303
+CTGGAT 64.12304 1.565592 1.369415 0.613315
+CTGGCA 57.186592 1.123949 1.141198 0.466576
+CTGGCC 55.708084 1.066671 0.941844 0.349824
+CTGGCG 56.72002 1.066909 1.120348 0.453848
+CTGGCT 57.512121 1.152476 1.079472 0.429238
+CTGGGA 63.22229 1.425619 1.240652 0.528878
+CTGGGC 60.064058 1.029146 1.188426 0.495837
+CTGGGG 62.403294 1.279782 1.117551 0.452149
+CTGGGT 62.736234 1.263693 1.158192 0.477036
+CTGGTA 60.27314 1.051177 1.153262 0.473994
+CTGGTC 58.616994 0.971212 1.269631 0.547516
+CTGGTG 60.00028 1.008192 1.169148 0.483821
+CTGGTT 60.45984 1.088116 1.369333 0.613259
+CTGTAA 50.793213 1.036148 1.133433 0.461822
+CTGTAC 49.307364 0.900252 1.170948 0.484939
+CTGTAG 50.271238 1.041362 1.212794 0.511165
+CTGTAT 50.090915 0.739237 1.06098 0.418255
+CTGTCA 44.056424 1.317611 1.610938 0.782526
+CTGTCC 42.956016 1.35461 1.501355 0.704054
+CTGTCG 43.762938 1.257768 1.555764 0.742671
+CTGTCT 43.693656 1.19142 1.454458 0.671324
+CTGTGA 49.521552 0.973202 1.142311 0.467258
+CTGTGC 47.885363 0.839525 1.095293 0.438709
+CTGTGG 48.784032 1.083215 1.160276 0.478324
+CTGTGT 48.537042 0.798673 1.03705 0.404185
+CTGTTA 44.884308 0.899978 1.184458 0.493356
+CTGTTC 43.616561 1.179039 1.338129 0.592417
+CTGTTG 44.622738 0.870306 1.123955 0.456041
+CTGTTT 44.523462 1.078651 1.123765 0.455926
+CTTAAA 63.884639 2.197355 1.393345 0.629461
+CTTAAC 62.869069 1.324908 1.193739 0.499165
+CTTAAG 63.842467 2.154651 1.427665 0.65286
+CTTAAT 64.326162 1.956728 1.468263 0.680905
+CTTACA 59.064894 1.660073 1.169422 0.483991
+CTTACC 58.122786 1.695256 1.035456 0.403253
+CTTACG 58.63558 1.705382 1.216599 0.513573
+CTTACT 58.998474 1.903067 1.19964 0.502872
+CTTAGA 64.154933 2.197355 1.455303 0.671909
+CTTAGC 63.240665 1.622468 1.402015 0.635345
+CTTAGG 64.174843 2.197355 1.427164 0.652516
+CTTAGT 64.729087 2.197355 1.511867 0.711461
+CTTATA 61.365647 1.308393 1.148326 0.470954
+CTTATC 60.037713 1.591825 1.230783 0.52258
+CTTATG 61.143638 1.32174 1.215887 0.513122
+CTTATT 60.995591 1.61117 1.415189 0.644321
+CTTCAA 60.394617 2.197355 1.631842 0.797807
+CTTCAC 59.204186 2.197355 1.491233 0.696946
+CTTCAG 59.62662 2.197355 1.765467 0.89778
+CTTCAT 60.361561 2.197355 1.740634 0.878904
+CTTCCA 55.956467 2.197355 1.580378 0.760365
+CTTCCC 55.113583 2.197355 1.514222 0.713124
+CTTCCG 55.473956 2.197355 1.560742 0.746238
+CTTCCT 55.697541 2.197355 1.537223 0.729434
+CTTCGA 59.952179 2.197355 1.802704 0.926333
+CTTCGC 58.347916 2.197355 1.559115 0.745072
+CTTCGG 58.811752 2.197355 1.729645 0.870595
+CTTCGT 59.139405 2.197355 1.801255 0.925217
+CTTCTA 56.752272 2.197355 1.487521 0.694345
+CTTCTC 56.886921 2.197355 1.291739 0.561879
+CTTCTG 56.842931 2.197355 1.516052 0.714417
+CTTCTT 57.954067 2.197355 1.493736 0.698701
+CTTGAA 56.118609 1.932211 1.293286 0.562889
+CTTGAC 53.464937 1.19603 0.92276 0.339245
+CTTGAG 55.474952 1.71078 1.300168 0.567387
+CTTGAT 55.145676 1.628979 1.185767 0.494174
+CTTGCA 50.747702 1.10537 1.409762 0.640619
+CTTGCC 49.705386 1.111109 1.100482 0.44183
+CTTGCG 50.539268 1.189639 1.311921 0.575098
+CTTGCT 50.682847 1.176912 1.124456 0.456346
+CTTGGA 56.40389 2.197355 1.185828 0.494212
+CTTGGC 54.93445 1.503087 1.000964 0.383273
+CTTGGG 55.234877 2.09432 1.176574 0.488438
+CTTGGT 56.336358 1.681155 1.100822 0.442035
+CTTGTA 53.697334 1.11643 0.938753 0.348103
+CTTGTC 52.589533 0.895792 0.994685 0.379672
+CTTGTG 53.531002 1.072117 0.974222 0.368017
+CTTGTT 53.689154 1.280262 1.11219 0.4489
+CTTTAA 50.15076 1.397864 1.137445 0.464276
+CTTTAC 49.132554 1.029233 0.98563 0.374499
+CTTTAG 49.825219 1.273975 1.163138 0.480095
+CTTTAT 49.68103 1.20569 1.010835 0.388956
+CTTTCA 44.70838 0.93313 1.307485 0.572184
+CTTTCC 43.50896 0.806163 1.062556 0.419188
+CTTTCG 44.492755 0.899478 1.265476 0.544831
+CTTTCT 44.331385 0.885554 1.045773 0.409295
+CTTTGA 49.129531 1.155672 1.008108 0.387383
+CTTTGC 48.050738 0.749197 0.807636 0.277782
+CTTTGG 48.555151 1.044244 0.944699 0.351415
+CTTTGT 48.438394 0.928288 0.855829 0.303013
+CTTTTA 45.252293 0.787101 0.866698 0.308804
+CTTTTC 43.978545 0.621749 0.904373 0.329156
+CTTTTG 44.900299 0.727204 0.761661 0.254403
+CTTTTT 44.658692 0.526084 0.725946 0.236721
+GAAAAA 64.509406 0.841539 0.837289 0.29322
+GAAAAC 62.57011 0.963549 1.081465 0.430427
+GAAAAG 64.045597 0.767942 0.87084 0.31102
+GAAAAT 64.208454 0.745794 0.947779 0.353135
+GAAACA 57.304019 1.143114 1.265662 0.544951
+GAAACC 56.411264 1.421468 1.270631 0.548163
+GAAACG 57.228948 1.137675 1.224695 0.518708
+GAAACT 57.299952 0.987529 1.089823 0.435426
+GAAAGA 64.929508 0.901018 0.876435 0.314022
+GAAAGC 63.832359 0.915507 1.092104 0.436794
+GAAAGG 64.404097 0.822354 0.85007 0.29996
+GAAAGT 64.669833 0.783609 0.991961 0.378114
+GAAATA 61.170108 1.14893 1.165586 0.481612
+GAAATC 60.642227 1.457306 1.317165 0.57855
+GAAATG 60.998835 1.205346 1.193489 0.499009
+GAAATT 61.767226 1.204978 1.347022 0.598332
+GAACAA 60.289071 1.361731 1.007889 0.387258
+GAACAC 59.942104 1.157771 0.904219 0.329072
+GAACAG 59.730254 1.380152 1.040716 0.40633
+GAACAT 60.39992 1.337651 1.029616 0.399847
+GAACCA 56.064972 0.93443 1.084024 0.431955
+GAACCC 55.38746 0.903434 1.06656 0.421559
+GAACCG 55.757828 0.931194 1.105495 0.444852
+GAACCT 55.863789 0.936754 0.946515 0.352429
+GAACGA 59.723572 1.441308 1.058677 0.416894
+GAACGC 59.506163 1.101674 0.974647 0.368258
+GAACGG 58.941934 1.337164 1.026756 0.398182
+GAACGT 59.456331 1.208366 1.084993 0.432535
+GAACTA 58.073691 0.847514 0.830485 0.289653
+GAACTC 57.652615 0.74441 0.870523 0.31085
+GAACTG 57.569559 0.973523 0.883382 0.317763
+GAACTT 58.080985 0.783923 0.969184 0.365166
+GAAGAA 63.733056 0.97463 1.055821 0.415208
+GAAGAC 62.12168 0.8303 0.998677 0.381961
+GAAGAG 63.192196 0.994844 1.104196 0.444069
+GAAGAT 63.712665 0.911998 1.129723 0.459556
+GAAGCA 58.4224 1.425075 1.528346 0.723125
+GAAGCC 57.523439 1.271892 1.384426 0.623427
+GAAGCG 58.151916 1.426033 1.4888 0.69524
+GAAGCT 58.63007 1.334575 1.413904 0.643443
+GAAGGA 62.822637 0.948244 1.079614 0.429322
+GAAGGC 62.081815 0.856096 1.073829 0.425876
+GAAGGG 62.388793 0.933141 0.966208 0.363485
+GAAGGT 63.079441 0.772447 0.971114 0.366257
+GAAGTA 60.296699 1.168263 1.321077 0.581129
+GAAGTC 59.238582 1.441058 1.5231 0.719405
+GAAGTG 60.129846 1.26639 1.26533 0.544736
+GAAGTT 60.594213 1.296439 1.392851 0.629126
+GAATAA 55.469748 1.241382 1.304458 0.570198
+GAATAC 54.280544 1.089829 1.280867 0.554801
+GAATAG 55.222597 1.33668 1.37086 0.614285
+GAATAT 55.125702 1.197268 1.300755 0.567772
+GAATCA 50.507834 1.576413 1.705591 0.852498
+GAATCC 49.406539 1.266718 1.620855 0.789763
+GAATCG 50.311115 1.484308 1.662576 0.820451
+GAATCT 49.967487 1.418164 1.475809 0.686161
+GAATGA 54.08728 1.095001 1.212709 0.511111
+GAATGC 53.09124 1.293792 1.533179 0.726557
+GAATGG 53.491136 1.068063 1.221927 0.51695
+GAATGT 53.385562 0.989445 1.259512 0.540984
+GAATTA 50.617248 1.48295 1.581618 0.76126
+GAATTC 49.281125 1.734115 1.871382 0.979771
+GAATTG 50.50284 1.563465 1.581809 0.761398
+GAATTT 50.124305 1.638638 1.711696 0.857078
+GACAAA 66.070326 0.701129 0.831722 0.2903
+GACAAC 64.266168 0.647245 0.864399 0.307576
+GACAAG 65.769497 0.737085 0.816341 0.282285
+GACAAT 65.930186 0.612197 0.851892 0.300924
+GACACA 62.530847 0.619018 0.759487 0.253315
+GACACC 61.547603 0.573461 0.740203 0.243729
+GACACG 62.224983 0.553053 0.759728 0.253436
+GACACT 62.68014 0.828093 0.777227 0.262242
+GACAGA 67.44092 0.885788 0.900778 0.327196
+GACAGC 66.46175 0.808683 0.910911 0.332732
+GACAGG 67.081043 0.799521 0.841221 0.295288
+GACAGT 67.526974 0.943088 1.052696 0.413366
+GACATA 65.40531 0.662017 0.813392 0.280757
+GACATC 64.864175 0.667628 0.933143 0.344987
+GACATG 65.265167 0.690699 0.930228 0.343372
+GACATT 65.709699 0.717296 1.179708 0.490391
+GACCAA 63.935495 1.664127 0.943227 0.350594
+GACCAC 63.030189 1.835807 0.829309 0.289038
+GACCAG 63.675963 1.965968 1.043782 0.408127
+GACCAT 64.0826 1.665688 1.061374 0.418489
+GACCCA 60.973036 1.439681 0.89812 0.325748
+GACCCC 60.018698 1.268798 0.857753 0.304035
+GACCCG 60.373327 1.417967 0.900273 0.32692
+GACCCT 60.579033 1.387054 0.947767 0.353129
+GACCGA 63.521661 1.776073 0.968767 0.36493
+GACCGC 62.74353 1.668309 0.834692 0.291857
+GACCGG 63.133987 1.725856 1.03937 0.405542
+GACCGT 63.30499 1.72535 1.189576 0.496557
+GACCTA 62.261738 2.007846 0.85688 0.303571
+GACCTC 61.621499 1.062563 0.816139 0.28218
+GACCTG 61.97457 1.315876 0.864263 0.307503
+GACCTT 61.969761 1.17454 0.997138 0.381078
+GACGAA 66.285374 1.253006 0.94866 0.353628
+GACGAC 65.254868 0.643892 0.716448 0.232091
+GACGAG 66.220192 1.218876 0.970299 0.365796
+GACGAT 66.240604 1.160106 0.992892 0.378646
+GACGCA 61.629051 0.872296 0.871793 0.311531
+GACGCC 61.038004 0.664802 0.714425 0.231108
+GACGCG 61.512334 0.81737 0.833636 0.291303
+GACGCT 61.874969 1.019291 0.870659 0.310923
+GACGGA 64.863485 1.096112 0.90004 0.326793
+GACGGC 64.034495 0.797319 0.954499 0.356898
+GACGGG 64.872165 0.914699 0.874072 0.312753
+GACGGT 65.090339 0.936019 1.027164 0.39842
+GACGTA 62.241862 0.939041 0.995441 0.380105
+GACGTC 60.798084 1.261626 1.212643 0.51107
+GACGTG 62.151596 0.890076 0.966441 0.363617
+GACGTT 62.407056 1.015846 1.093408 0.437577
+GACTAA 59.775858 0.65738 0.716433 0.232083
+GACTAC 58.795143 0.537827 0.685616 0.217271
+GACTAG 59.550053 0.627566 0.715669 0.231712
+GACTAT 59.498058 0.556044 0.721408 0.234505
+GACTCA 55.742174 0.837937 1.049742 0.411628
+GACTCC 54.926567 0.961057 0.984979 0.374129
+GACTCG 55.681056 0.833792 1.011172 0.389151
+GACTCT 55.498624 0.836887 0.924862 0.340405
+GACTGA 57.971135 0.783365 0.773839 0.260529
+GACTGC 56.176316 1.044286 1.060518 0.417982
+GACTGG 57.487976 0.756049 0.717092 0.232403
+GACTGT 57.231619 0.770165 0.811451 0.279753
+GACTTA 54.643942 1.171043 1.056092 0.415368
+GACTTC 52.767997 1.703962 1.30924 0.573337
+GACTTG 54.408854 1.318668 1.027493 0.398611
+GACTTT 54.039449 1.437882 1.086241 0.433281
+GAGAAA 74.604624 1.565082 1.417677 0.646021
+GAGAAC 72.939415 1.136134 1.447387 0.666434
+GAGAAG 74.429512 1.517864 1.347048 0.59835
+GAGAAT 74.732854 1.582844 1.66534 0.822498
+GAGACA 64.157776 1.338308 1.015142 0.391445
+GAGACC 63.284449 1.123268 1.097727 0.440172
+GAGACG 63.83298 1.022836 1.021515 0.395137
+GAGACT 64.430079 1.097057 1.109652 0.447364
+GAGAGA 73.610332 1.546469 1.43692 0.659219
+GAGAGC 72.099682 1.150202 1.34684 0.598211
+GAGAGG 72.645258 1.464612 1.379437 0.62006
+GAGAGT 73.366021 1.46699 1.673462 0.828522
+GAGATA 68.343758 1.155452 1.29948 0.566938
+GAGATC 68.073947 1.272823 1.462263 0.676736
+GAGATG 68.27545 1.143872 1.374418 0.616679
+GAGATT 69.572732 1.168519 1.626213 0.793683
+GAGCAA 69.978748 1.633797 1.293098 0.562766
+GAGCAC 69.011836 1.42762 1.295434 0.564292
+GAGCAG 68.938385 1.907268 1.265428 0.5448
+GAGCAT 70.002788 1.585653 1.332697 0.588814
+GAGCCA 63.881354 1.217757 1.009888 0.38841
+GAGCCC 62.539995 1.647905 1.019076 0.393723
+GAGCCG 63.645304 1.171588 0.983158 0.373092
+GAGCCT 63.393704 1.209834 1.027692 0.398726
+GAGCGA 68.991215 2.11368 1.255851 0.538627
+GAGCGC 68.336505 1.577416 1.264241 0.544033
+GAGCGG 67.986237 1.783851 1.265958 0.545142
+GAGCGT 68.514652 1.374315 1.386063 0.624533
+GAGCTA 66.636287 1.277774 1.221879 0.51692
+GAGCTC 66.020254 1.33943 1.20346 0.505275
+GAGCTG 65.864133 1.273153 1.273386 0.549947
+GAGCTT 66.522009 1.483279 1.489458 0.695701
+GAGGAA 69.533866 1.505605 1.31401 0.576473
+GAGGAC 67.374119 1.1927 1.085392 0.432773
+GAGGAG 68.814453 1.522745 1.24613 0.532385
+GAGGAT 69.171591 1.301385 1.335553 0.590707
+GAGGCA 62.039957 0.987789 1.240272 0.528635
+GAGGCC 61.142801 1.074078 1.162325 0.479592
+GAGGCG 61.763772 1.051443 1.183343 0.492659
+GAGGCT 62.534697 1.006509 1.192503 0.49839
+GAGGGA 67.427651 1.252121 1.140209 0.465969
+GAGGGC 65.531628 1.017209 1.114178 0.450104
+GAGGGG 66.559198 1.398819 1.146812 0.470023
+GAGGGT 67.24008 1.091994 1.202523 0.504685
+GAGGTA 65.156552 1.182717 1.193131 0.498785
+GAGGTC 63.950787 1.419084 1.36527 0.610532
+GAGGTG 64.893832 1.139354 1.223961 0.518241
+GAGGTT 65.68032 1.189573 1.415557 0.644572
+GAGTAA 55.146777 1.55901 1.415048 0.644225
+GAGTAC 53.670562 1.238846 1.390725 0.627686
+GAGTAG 54.764896 1.668098 1.487007 0.693985
+GAGTAT 54.558003 1.460499 1.350603 0.60072
+GAGTCA 48.40983 1.639043 1.782147 0.910533
+GAGTCC 47.024347 1.523799 1.657517 0.81671
+GAGTCG 48.229059 1.72598 1.873428 0.981378
+GAGTCT 48.073501 1.402245 1.613494 0.784389
+GAGTGA 53.865026 1.602137 1.310722 0.57431
+GAGTGC 52.761128 1.413975 1.555479 0.742467
+GAGTGG 52.989511 1.556328 1.320708 0.580886
+GAGTGT 52.910493 1.397382 1.298717 0.566438
+GAGTTA 49.138925 1.70434 1.504586 0.706328
+GAGTTC 47.840442 1.617558 1.780095 0.908961
+GAGTTG 48.801464 1.669404 1.462284 0.67675
+GAGTTT 48.733519 1.539721 1.672715 0.827968
+GATAAA 62.575143 1.34119 0.976512 0.369315
+GATAAC 61.675983 0.809422 0.835546 0.292305
+GATAAG 62.347884 1.372549 1.076569 0.427507
+GATAAT 62.743079 1.452289 1.058769 0.416948
+GATACA 57.867272 0.953488 0.935612 0.346357
+GATACC 57.353805 0.914044 0.858597 0.304484
+GATACG 57.854185 1.099956 0.927626 0.341932
+GATACT 58.12672 0.971382 0.905959 0.330023
+GATAGA 62.460983 1.346966 1.091284 0.436302
+GATAGC 61.983795 0.919331 0.977459 0.369852
+GATAGG 62.12574 1.253085 0.963749 0.362098
+GATAGT 63.066527 1.233886 1.134166 0.46227
+GATATA 60.03285 0.835656 0.850385 0.300126
+GATATC 59.237913 0.851586 0.935108 0.346077
+GATATG 59.874134 0.839087 0.888126 0.320326
+GATATT 60.042772 0.977359 1.06628 0.421393
+GATCAA 58.38193 1.905653 1.228019 0.520821
+GATCAC 57.814906 1.676325 1.084103 0.432003
+GATCAG 57.994175 2.115195 1.324162 0.583166
+GATCAT 58.461402 1.995494 1.358302 0.605864
+GATCCA 54.675462 1.788324 1.242696 0.530186
+GATCCC 53.900757 1.524791 1.117615 0.452188
+GATCCG 54.396875 1.640682 1.234642 0.52504
+GATCCT 54.340077 1.637344 1.095319 0.438724
+GATCGA 57.718771 1.964684 1.304888 0.57048
+GATCGC 57.654487 1.724287 1.172265 0.485757
+GATCGG 57.258909 1.863493 1.259347 0.540877
+GATCGT 57.758649 1.750789 1.352406 0.601923
+GATCTA 55.814352 1.4806 1.029622 0.39985
+GATCTC 55.458217 1.530476 1.007354 0.386949
+GATCTG 55.695236 1.459982 1.063709 0.41987
+GATCTT 56.29512 1.269174 1.094188 0.438045
+GATGAA 56.412287 1.251607 1.168048 0.483139
+GATGAC 54.454419 0.717707 0.879105 0.315458
+GATGAG 55.701437 1.130661 1.1278 0.458383
+GATGAT 55.841729 1.043442 1.100999 0.442141
+GATGCA 51.093336 0.838197 1.354397 0.603253
+GATGCC 50.399324 0.813803 1.201237 0.503876
+GATGCG 50.998227 0.947394 1.330977 0.587674
+GATGCT 51.19778 0.802989 1.184251 0.493226
+GATGGA 56.075922 1.265004 1.109119 0.447041
+GATGGC 55.635869 0.887479 0.90571 0.329886
+GATGGG 55.720538 1.131757 0.922783 0.339258
+GATGGT 56.572412 1.069111 1.0362 0.403688
+GATGTA 53.813713 0.770171 0.911256 0.332921
+GATGTC 52.886247 0.655912 0.999697 0.382546
+GATGTG 53.689437 0.725831 0.903911 0.328904
+GATGTT 53.969476 0.759226 1.033511 0.402118
+GATTAA 49.858189 0.922617 1.112481 0.449076
+GATTAC 49.215364 0.64397 1.009536 0.388207
+GATTAG 49.674785 0.835014 1.108403 0.446609
+GATTAT 49.686708 0.693702 0.984453 0.373829
+GATTCA 44.844543 0.840817 1.441977 0.662702
+GATTCC 44.033535 0.840638 1.317184 0.578563
+GATTCG 44.90312 0.818569 1.482635 0.690927
+GATTCT 44.546654 0.753367 1.223851 0.518172
+GATTGA 49.006152 0.813431 1.070357 0.423812
+GATTGC 48.377291 0.575906 0.845554 0.297572
+GATTGG 48.606025 0.688704 0.963933 0.362202
+GATTGT 48.657563 0.631426 0.88878 0.32068
+GATTTA 45.49487 0.795381 1.006991 0.38674
+GATTTC 44.141425 0.81669 1.071629 0.424568
+GATTTG 45.240644 0.740938 0.938366 0.347888
+GATTTT 44.996374 0.71567 0.932061 0.344387
+GCAAAA 65.064198 0.7919 0.952004 0.3555
+GCAAAC 61.66708 0.846809 1.143663 0.468088
+GCAAAG 64.468621 0.899117 0.95352 0.356349
+GCAAAT 63.971392 0.743252 1.082108 0.430811
+GCAACA 58.583269 0.827913 1.147902 0.470693
+GCAACC 57.226447 0.789666 1.098519 0.440648
+GCAACG 58.287256 0.807285 1.137243 0.464152
+GCAACT 58.435203 0.746438 1.060966 0.418247
+GCAAGA 66.3253 0.844402 0.983148 0.373086
+GCAAGC 64.357374 0.85814 1.174895 0.487393
+GCAAGG 65.62933 0.788902 0.96164 0.360911
+GCAAGT 65.770857 0.893847 1.176585 0.488445
+GCAATA 62.043154 1.041505 1.157772 0.476777
+GCAATC 60.777148 1.434798 1.395157 0.630689
+GCAATG 61.879642 0.990413 1.170632 0.484743
+GCAATT 62.194897 1.074134 1.345224 0.597135
+GCACAA 67.188729 1.780942 1.094336 0.438134
+GCACAC 66.309838 1.210755 0.989707 0.376826
+GCACAG 66.809593 1.616442 1.144455 0.468574
+GCACAT 66.982603 1.702331 1.149228 0.471509
+GCACCA 62.507742 1.239436 0.966577 0.363693
+GCACCC 61.480396 1.055737 0.910329 0.332413
+GCACCG 62.093065 1.195572 0.969019 0.365073
+GCACCT 62.12349 1.20331 0.946219 0.352264
+GCACGA 66.544011 1.742696 1.018157 0.39319
+GCACGC 65.624041 1.164408 0.989578 0.376752
+GCACGG 65.808418 1.510664 1.069791 0.423476
+GCACGT 66.551584 1.360831 1.200122 0.503175
+GCACTA 64.232328 0.98966 0.927906 0.342087
+GCACTC 62.843695 1.005429 0.997552 0.381315
+GCACTG 63.428702 1.053187 0.991944 0.378104
+GCACTT 63.752003 0.990292 1.230597 0.522462
+GCAGAA 65.313999 1.001467 1.002724 0.384284
+GCAGAC 62.236729 1.213265 1.081421 0.4304
+GCAGAG 64.621045 1.064626 1.068689 0.422822
+GCAGAT 64.421349 0.950945 1.193649 0.499109
+GCAGCA 59.691094 1.227246 1.363226 0.609161
+GCAGCC 58.317072 1.057704 1.315694 0.577581
+GCAGCG 59.417012 1.115327 1.313652 0.576237
+GCAGCT 59.839831 1.062855 1.321852 0.581641
+GCAGGA 64.678816 0.86967 1.003649 0.384816
+GCAGGC 62.565729 1.2791 1.200662 0.503515
+GCAGGG 64.323363 0.94395 0.969167 0.365156
+GCAGGT 64.470354 0.842669 1.063564 0.419784
+GCAGTA 60.139918 1.985644 1.588192 0.766011
+GCAGTC 57.893464 2.197355 1.984926 1.070279
+GCAGTG 60.326843 1.860364 1.469638 0.681861
+GCAGTT 59.959304 2.197355 1.669947 0.825913
+GCATAA 59.600148 1.024807 1.057121 0.415976
+GCATAC 57.782903 1.069076 1.084354 0.432153
+GCATAG 59.369239 1.079214 1.10262 0.443118
+GCATAT 58.974199 0.940916 1.106701 0.445581
+GCATCA 54.250701 1.48488 1.525064 0.720797
+GCATCC 52.93421 1.389607 1.480631 0.689527
+GCATCG 54.163273 1.392165 1.44876 0.667383
+GCATCT 53.874239 1.255618 1.332511 0.588691
+GCATGA 57.512403 1.582317 1.300434 0.567562
+GCATGC 54.821099 1.87555 1.613816 0.784624
+GCATGG 56.73612 1.53094 1.221466 0.516658
+GCATGT 56.390405 1.698618 1.32357 0.582775
+GCATTA 52.729266 2.13163 1.722032 0.864854
+GCATTC 50.03967 2.197355 2.173317 1.226211
+GCATTG 52.740301 2.167978 1.724946 0.86705
+GCATTT 51.589305 2.197355 1.817753 0.937957
+GCCAAA 67.192064 0.81497 0.91901 0.337179
+GCCAAC 64.258291 1.027476 1.028844 0.399397
+GCCAAG 66.936629 0.743475 0.926194 0.341141
+GCCAAT 66.687185 0.809505 1.064645 0.420424
+GCCACA 63.760155 0.658957 0.856062 0.303137
+GCCACC 62.462766 0.725286 0.863028 0.306844
+GCCACG 63.465532 0.666533 0.848128 0.298932
+GCCACT 63.723562 0.65683 0.86934 0.310217
+GCCAGA 69.706868 0.825839 0.932167 0.344446
+GCCAGC 67.923316 0.781783 0.980318 0.371476
+GCCAGG 69.22873 0.769659 0.905966 0.330026
+GCCAGT 69.358132 0.899318 1.31711 0.578514
+GCCATA 67.048109 0.744577 0.899763 0.326643
+GCCATC 65.576356 1.166078 1.07669 0.42758
+GCCATG 66.82588 0.797849 1.036403 0.403807
+GCCATT 67.053812 0.929798 1.246361 0.532533
+GCCCAA 69.24028 1.289518 1.032711 0.401651
+GCCCAC 67.62503 1.136659 0.862124 0.306362
+GCCCAG 68.65907 1.715602 1.077737 0.428203
+GCCCAT 69.339134 1.451154 1.08644 0.4334
+GCCCCA 66.09899 1.299838 0.86449 0.307624
+GCCCCC 64.879526 1.19329 0.742648 0.244937
+GCCCCG 65.726769 1.338253 0.86831 0.309666
+GCCCCT 65.671816 1.308984 0.883172 0.31765
+GCCCGA 68.959666 1.937157 1.000089 0.382771
+GCCCGC 67.650104 1.250401 0.897635 0.325485
+GCCCGG 68.161215 1.794372 1.030534 0.400381
+GCCCGT 68.50705 1.508686 1.305699 0.571012
+GCCCTA 67.069739 1.129617 0.868583 0.309812
+GCCCTC 65.492639 0.87446 0.868129 0.309569
+GCCCTG 66.23203 1.136039 1.003663 0.384825
+GCCCTT 66.287385 1.051839 1.254949 0.538047
+GCCGAA 69.446723 1.149183 0.89498 0.324041
+GCCGAC 67.040046 0.701111 0.818797 0.28356
+GCCGAG 69.112424 1.092966 0.964224 0.362366
+GCCGAT 68.95851 0.94261 0.955975 0.357726
+GCCGCA 64.354448 0.874434 0.86153 0.306046
+GCCGCC 63.204917 0.708103 0.755558 0.251352
+GCCGCG 64.2128 0.82179 0.850663 0.300274
+GCCGCT 64.428174 0.892484 0.837358 0.293256
+GCCGGA 67.775876 0.886379 0.911074 0.332822
+GCCGGC 65.69164 1.429952 1.220626 0.516125
+GCCGGG 67.62448 0.869186 0.958579 0.359188
+GCCGGT 67.713834 0.783931 1.258499 0.540331
+GCCGTA 62.543038 2.197355 1.594539 0.770607
+GCCGTC 60.307449 2.197355 2.037106 1.112759
+GCCGTG 62.498505 2.197355 1.556976 0.743538
+GCCGTT 61.687799 2.197355 1.903729 1.005283
+GCCTAA 63.135229 0.735365 0.726947 0.237211
+GCCTAC 61.212159 0.829128 0.743243 0.245232
+GCCTAG 62.710728 0.959593 0.740226 0.24374
+GCCTAT 62.313195 0.650061 0.778917 0.263098
+GCCTCA 58.523554 0.871425 0.999942 0.382686
+GCCTCC 57.396064 0.81639 0.955247 0.357317
+GCCTCG 58.379078 0.828005 0.974858 0.368377
+GCCTCT 58.150915 0.752106 0.920964 0.338255
+GCCTGA 59.842033 1.448891 1.032161 0.40133
+GCCTGC 57.193747 2.115692 1.363314 0.60922
+GCCTGG 59.536089 1.275403 0.909762 0.332102
+GCCTGT 58.560625 1.453125 1.098843 0.440843
+GCCTTA 55.405281 1.887927 1.388811 0.626391
+GCCTTC 52.707426 2.197355 1.833778 0.950387
+GCCTTG 55.624218 2.039986 1.280631 0.554647
+GCCTTT 54.12504 2.197355 1.543762 0.734093
+GCGAAA 72.59127 1.199994 1.230547 0.52243
+GCGAAC 69.663152 1.0741 1.183116 0.492517
+GCGAAG 72.185878 1.192645 1.226986 0.520164
+GCGAAT 72.251474 1.101757 1.487639 0.694427
+GCGACA 62.693467 0.907668 0.966347 0.363564
+GCGACC 61.446972 0.967442 1.129973 0.459709
+GCGACG 62.530085 0.930771 0.983856 0.373489
+GCGACT 62.867372 0.787063 1.024878 0.39709
+GCGAGA 71.41188 1.407779 1.267797 0.54633
+GCGAGC 68.587546 1.475502 1.303178 0.569359
+GCGAGG 70.716866 1.288289 1.156076 0.47573
+GCGAGT 70.832641 1.139634 1.494902 0.699519
+GCGATA 64.96482 1.587787 1.336228 0.591155
+GCGATC 63.480511 2.197355 1.612927 0.783976
+GCGATG 65.04813 1.588232 1.386281 0.62468
+GCGATT 65.201978 1.847731 1.647767 0.809514
+GCGCAA 71.343958 1.646299 1.31736 0.578678
+GCGCAC 69.931657 1.473008 1.181575 0.491556
+GCGCAG 71.069111 1.722329 1.236985 0.526535
+GCGCAT 71.279447 1.68514 1.397214 0.632084
+GCGCCA 65.775352 1.476221 0.910488 0.3325
+GCGCCC 65.018272 1.273156 0.882932 0.31752
+GCGCCG 65.521842 1.389233 0.881891 0.316959
+GCGCCT 65.921754 1.305635 0.938019 0.347695
+GCGCGA 71.278333 1.714402 1.236575 0.526273
+GCGCGC 69.396535 1.484181 1.180806 0.491076
+GCGCGG 70.278557 1.500554 1.283617 0.556588
+GCGCGT 69.694752 1.618724 1.605982 0.778918
+GCGCTA 67.780451 1.439948 1.160874 0.478694
+GCGCTC 66.564766 1.100079 1.221549 0.51671
+GCGCTG 67.176436 1.215746 1.196115 0.500657
+GCGCTT 67.599743 1.21648 1.431118 0.65523
+GCGGAA 63.259506 1.311398 1.265697 0.544973
+GCGGAC 59.058068 1.398785 1.339377 0.593246
+GCGGAG 62.296772 1.475693 1.29733 0.565531
+GCGGAT 62.153803 1.254062 1.369636 0.613463
+GCGGCA 56.534472 1.336045 1.627129 0.794353
+GCGGCC 55.207699 1.322156 1.566108 0.75009
+GCGGCG 56.351907 1.430086 1.633428 0.79897
+GCGGCT 56.95022 1.314481 1.524098 0.720112
+GCGGGA 60.128137 1.631113 1.558887 0.744908
+GCGGGC 56.851602 2.197355 1.705865 0.852703
+GCGGGG 59.120052 1.751403 1.460243 0.675333
+GCGGGT 59.327029 1.769632 1.488472 0.695011
+GCGGTA 56.127369 2.197355 1.848847 0.962127
+GCGGTC 53.643582 2.197355 2.291216 1.327332
+GCGGTG 56.010463 2.197355 1.8201 0.939774
+GCGGTT 55.372976 2.197355 2.011589 1.091917
+GCGTAA 48.328272 1.91345 1.792431 0.918426
+GCGTAC 47.418948 1.89925 1.836308 0.952355
+GCGTAG 48.434712 2.078703 1.9978 1.080709
+GCGTAT 48.196197 1.829796 1.765738 0.897987
+GCGTCA 42.763043 2.197355 2.218076 1.264286
+GCGTCC 41.53408 1.999255 2.095482 1.160932
+GCGTCG 42.48731 2.197355 2.14052 1.198559
+GCGTCT 42.607108 2.077921 1.985943 1.071102
+GCGTGA 46.882461 1.854977 1.929837 1.026034
+GCGTGC 45.536795 1.812953 1.808337 0.930678
+GCGTGG 46.259195 1.945179 1.862469 0.972779
+GCGTGT 46.012087 1.60352 1.682033 0.834896
+GCGTTA 42.632546 1.645473 1.901868 1.003809
+GCGTTC 41.310079 2.038976 1.827658 0.945634
+GCGTTG 42.664789 1.863508 1.847505 0.961079
+GCGTTT 42.248542 2.021016 1.741808 0.879794
+GCTAAA 67.200879 1.09085 0.9789 0.37067
+GCTAAC 64.801246 0.877749 0.929471 0.342953
+GCTAAG 67.269576 1.331461 1.029619 0.399849
+GCTAAT 67.154416 1.054767 1.098719 0.440768
+GCTACA 61.922404 1.059135 0.946436 0.352385
+GCTACC 60.496542 1.18111 0.827795 0.288247
+GCTACG 61.364457 1.21441 0.888814 0.320699
+GCTACT 61.82503 1.445892 0.899393 0.326441
+GCTAGA 67.18835 1.015355 1.016058 0.391975
+GCTAGC 65.316402 1.068273 0.990401 0.377222
+GCTAGG 67.108871 1.267792 1.023753 0.396436
+GCTAGT 67.075573 1.135178 1.256581 0.539096
+GCTATA 63.387775 0.85891 0.909971 0.332217
+GCTATC 62.042779 0.774805 0.952637 0.355854
+GCTATG 63.094646 0.874808 0.985168 0.374237
+GCTATT 63.413726 0.903151 1.187858 0.495482
+GCTCAA 64.185934 2.197355 1.270482 0.548066
+GCTCAC 63.451207 2.172146 1.070925 0.42415
+GCTCAG 64.085587 2.197355 1.338701 0.592797
+GCTCAT 63.882471 2.197355 1.345189 0.597112
+GCTCCA 60.482746 1.753903 1.215083 0.512613
+GCTCCC 59.56981 1.584285 1.076982 0.427753
+GCTCCG 59.981458 1.732765 1.189663 0.496611
+GCTCCT 60.135827 2.022036 1.171712 0.485413
+GCTCGA 64.105132 2.138005 1.357102 0.605061
+GCTCGC 62.65111 2.197355 1.070583 0.423947
+GCTCGG 63.173479 2.197355 1.297001 0.565316
+GCTCGT 63.588411 2.158142 1.381218 0.621261
+GCTCTA 61.859577 1.484638 1.028617 0.399265
+GCTCTC 60.531942 1.230361 1.022591 0.395761
+GCTCTG 61.178551 1.346106 1.103108 0.443412
+GCTCTT 61.099272 1.313913 1.250554 0.535223
+GCTGAA 57.353969 1.372291 1.22924 0.521598
+GCTGAC 53.93959 0.91671 1.087229 0.433872
+GCTGAG 56.411114 1.181162 1.186794 0.494816
+GCTGAT 56.028307 1.256841 1.212501 0.51098
+GCTGCA 51.422798 1.217899 1.52227 0.718816
+GCTGCC 49.994806 1.128742 1.401556 0.635033
+GCTGCG 50.964248 1.094548 1.515081 0.71373
+GCTGCT 51.251194 1.228513 1.367148 0.611792
+GCTGGA 57.380044 1.225594 1.125548 0.457011
+GCTGGC 56.021846 0.830015 0.929637 0.343045
+GCTGGG 56.841786 1.066192 0.990454 0.377253
+GCTGGT 57.302202 1.078995 1.012998 0.390205
+GCTGTA 54.063646 0.748478 1.002317 0.38405
+GCTGTC 52.20032 1.150582 1.273792 0.55021
+GCTGTG 53.866692 0.741262 0.996418 0.380665
+GCTGTT 53.981895 0.816982 1.089919 0.435484
+GCTTAA 51.042351 1.047873 1.196437 0.500859
+GCTTAC 49.962532 0.835469 1.163297 0.480194
+GCTTAG 50.76205 0.959835 1.183583 0.492809
+GCTTAT 50.674449 0.913336 1.106134 0.445238
+GCTTCA 45.03165 0.96783 1.501706 0.704301
+GCTTCC 43.95677 0.965523 1.441986 0.662708
+GCTTCG 44.725904 0.936813 1.509678 0.709916
+GCTTCT 44.698703 0.964137 1.349017 0.599662
+GCTTGA 49.840426 0.956084 1.192202 0.498202
+GCTTGC 48.60352 0.624264 1.002196 0.383981
+GCTTGG 49.300297 0.993356 1.191566 0.497804
+GCTTGT 49.244551 0.702306 0.965196 0.362914
+GCTTTA 45.463358 0.825965 1.207988 0.50813
+GCTTTC 43.621409 0.71487 1.09223 0.43687
+GCTTTG 45.035998 0.744323 1.075912 0.427116
+GCTTTT 44.710964 0.716769 1.030665 0.400458
+GGAAAA 69.43869 1.788268 1.385348 0.624049
+GGAAAC 67.918179 2.197355 1.73128 0.87183
+GGAAAG 68.885876 1.676045 1.338895 0.592926
+GGAAAT 69.116334 1.953567 1.71063 0.856278
+GGAACA 61.141214 2.148405 1.52349 0.719681
+GGAACC 60.441257 2.122447 1.766036 0.898214
+GGAACG 61.275127 2.197355 1.544059 0.734305
+GGAACT 61.820045 2.197355 1.592248 0.768948
+GGAAGA 69.720831 1.743087 1.432375 0.656093
+GGAAGC 69.447392 2.197355 1.727097 0.868672
+GGAAGG 69.252649 1.887756 1.362026 0.608357
+GGAAGT 69.818554 2.048024 1.67094 0.82665
+GGAATA 65.161702 2.197355 1.657378 0.816607
+GGAATC 65.192305 2.197355 1.934006 1.02936
+GGAATG 65.40915 2.197355 1.75666 0.891071
+GGAATT 66.440978 2.197355 1.889034 0.993666
+GGACAA 63.644123 0.931444 0.805994 0.276935
+GGACAC 63.658758 0.691239 0.88946 0.321048
+GGACAG 63.414234 0.882212 0.85237 0.301178
+GGACAT 63.906025 0.762799 0.881362 0.316674
+GGACCA 58.862777 0.775296 0.991915 0.378088
+GGACCC 57.710882 0.71739 0.911268 0.332927
+GGACCG 58.550466 0.8123 0.989884 0.376927
+GGACCT 58.667759 0.811322 0.960382 0.360202
+GGACGA 63.187663 0.890076 0.882221 0.317137
+GGACGC 62.820066 0.771916 0.915219 0.335095
+GGACGG 62.402404 0.791124 0.875382 0.313456
+GGACGT 62.744852 0.720771 0.949007 0.353822
+GGACTA 61.054351 0.7648 0.899497 0.326498
+GGACTC 60.362894 0.883866 1.038701 0.40515
+GGACTG 60.545887 0.855438 0.957908 0.358811
+GGACTT 60.965695 1.011415 1.19936 0.502695
+GGAGAA 68.239744 1.701686 1.436693 0.659063
+GGAGAC 66.979931 1.952576 1.615646 0.785959
+GGAGAG 67.626415 1.856794 1.440013 0.661349
+GGAGAT 68.153403 2.158699 1.438559 0.660347
+GGAGCA 61.610303 1.809965 1.653668 0.813866
+GGAGCC 60.553147 1.645591 1.510967 0.710826
+GGAGCG 61.476589 1.784958 1.635481 0.800477
+GGAGCT 61.695095 1.591557 1.523289 0.719539
+GGAGGA 66.500878 1.588012 1.244492 0.531336
+GGAGGC 66.314556 2.091844 1.693752 0.843636
+GGAGGG 66.239636 1.957096 1.317899 0.579033
+GGAGGT 67.628455 1.704671 1.479174 0.688509
+GGAGTA 63.923421 2.173141 1.668677 0.824972
+GGAGTC 63.200396 2.197355 1.901445 1.003475
+GGAGTG 63.751816 2.178005 1.672082 0.827498
+GGAGTT 64.133838 2.197355 1.891933 0.995954
+GGATAA 57.508645 1.429772 1.360443 0.607297
+GGATAC 56.228837 1.450168 1.399635 0.633728
+GGATAG 57.494036 1.535293 1.389941 0.627155
+GGATAT 57.020516 1.362046 1.400535 0.634339
+GGATCA 51.866213 1.554777 1.858855 0.969949
+GGATCC 50.959867 1.520878 1.885164 0.990614
+GGATCG 51.642711 1.644798 1.812151 0.933625
+GGATCT 51.282572 1.589516 1.705021 0.85207
+GGATGA 56.486256 1.76974 1.483784 0.69173
+GGATGC 55.442874 2.086415 1.807131 0.929747
+GGATGG 55.483595 1.681108 1.364372 0.60993
+GGATGT 55.618424 1.726996 1.559785 0.745552
+GGATTA 52.349087 1.854969 1.996949 1.080018
+GGATTC 50.397538 2.197355 2.300734 1.335612
+GGATTG 51.977177 2.120394 1.910105 1.010338
+GGATTT 51.907348 2.197355 2.14684 1.203871
+GGCAAA 68.671592 1.654243 1.274726 0.550815
+GGCAAC 66.618778 2.197355 1.513845 0.712858
+GGCAAG 68.523302 1.614831 1.302605 0.568984
+GGCAAT 68.047177 1.79401 1.512087 0.711616
+GGCACA 64.357371 1.55763 1.253781 0.537296
+GGCACC 63.826132 2.010226 1.25466 0.537861
+GGCACG 64.108041 1.557366 1.222827 0.517521
+GGCACT 64.918811 1.791864 1.253263 0.536963
+GGCAGA 70.134871 1.332214 1.189198 0.49632
+GGCAGC 69.344424 2.120803 1.40984 0.640672
+GGCAGG 69.599518 1.368978 1.140654 0.466242
+GGCAGT 69.943156 1.630661 1.668146 0.824578
+GGCATA 67.654718 1.885547 1.323879 0.58298
+GGCATC 66.98228 2.197355 1.535347 0.728099
+GGCATG 67.164755 1.935392 1.451447 0.669241
+GGCATT 67.838141 1.879286 1.719526 0.862966
+GGCCAA 67.167395 0.858423 0.938173 0.34778
+GGCCAC 66.272517 0.723228 0.87777 0.31474
+GGCCAG 66.66809 0.828679 0.914393 0.334641
+GGCCAT 67.367042 1.010212 0.995979 0.380413
+GGCCCA 63.847463 0.872075 0.898325 0.32586
+GGCCCC 63.016699 0.862541 0.857463 0.303881
+GGCCCG 63.474424 0.861902 0.898581 0.325999
+GGCCCT 63.628415 0.828015 0.821167 0.284792
+GGCCGA 67.03094 0.850793 0.855133 0.302643
+GGCCGC 66.42844 0.900302 0.888375 0.320461
+GGCCGG 66.178866 0.777938 0.876915 0.31428
+GGCCGT 66.722918 0.720426 0.975132 0.368532
+GGCCTA 65.153966 0.772982 0.871537 0.311394
+GGCCTC 64.389542 1.043822 1.002257 0.384016
+GGCCTG 64.700808 0.839723 0.985153 0.374228
+GGCCTT 64.92848 0.983669 1.29934 0.566846
+GGCGAA 69.800536 1.215152 1.123443 0.45573
+GGCGAC 68.821927 1.814759 1.2519 0.536087
+GGCGAG 69.629914 1.441276 1.161588 0.479136
+GGCGAT 69.922678 1.233997 1.300769 0.567781
+GGCGCA 64.960584 1.356748 1.250239 0.53502
+GGCGCC 64.265572 1.534258 1.09819 0.44045
+GGCGCG 64.686407 1.321833 1.246257 0.532466
+GGCGCT 64.984422 1.219605 1.174559 0.487184
+GGCGGA 68.023216 1.301811 1.207191 0.507627
+GGCGGC 67.333768 2.197355 1.584016 0.762992
+GGCGGG 67.73464 1.377997 1.318395 0.57936
+GGCGGT 68.148348 1.506947 1.693517 0.843461
+GGCGTA 64.596526 2.197355 1.710696 0.856327
+GGCGTC 63.653917 2.197355 1.99981 1.08234
+GGCGTG 64.396418 2.197355 1.795037 0.92043
+GGCGTT 64.650994 2.197355 2.035852 1.111731
+GGCTAA 62.287272 1.250808 1.125243 0.456826
+GGCTAC 61.258808 1.755567 1.167008 0.482494
+GGCTAG 62.411531 1.346343 1.066454 0.421496
+GGCTAT 61.963889 1.623363 1.149188 0.471485
+GGCTCA 57.775794 1.611226 1.450638 0.668681
+GGCTCC 56.877385 1.72844 1.413795 0.643369
+GGCTCG 57.668624 1.614232 1.444131 0.664187
+GGCTCT 57.486523 1.566023 1.322743 0.582229
+GGCTGA 60.600865 1.913617 1.447521 0.666527
+GGCTGC 58.88394 2.197355 1.680667 0.833879
+GGCTGG 60.356464 2.021499 1.334922 0.590289
+GGCTGT 59.652672 2.197355 1.489973 0.696063
+GGCTTA 56.420163 2.197355 1.664756 0.822065
+GGCTTC 54.559968 2.197355 2.06689 1.137252
+GGCTTG 57.053489 2.197355 1.605501 0.778568
+GGCTTT 55.584693 2.197355 1.861999 0.972411
+GGGAAA 79.714908 1.763576 1.832435 0.949344
+GGGAAC 77.526683 1.553023 1.907209 1.008041
+GGGAAG 79.187088 1.7504 1.814212 0.935218
+GGGAAT 79.749907 1.671691 2.126557 1.186851
+GGGACA 67.113668 1.556204 1.259907 0.541238
+GGGACC 66.746985 1.587281 1.367241 0.611855
+GGGACG 67.331422 1.453117 1.310247 0.573998
+GGGACT 67.614103 1.530727 1.48702 0.693994
+GGGAGA 78.14777 1.865369 1.781597 0.910112
+GGGAGC 76.797701 1.557763 1.749855 0.885898
+GGGAGG 77.169708 1.987616 1.779132 0.908224
+GGGAGT 78.422253 1.581746 2.010945 1.091393
+GGGATA 72.571185 1.689372 1.732809 0.872985
+GGGATC 71.941913 2.024785 2.02038 1.099082
+GGGATG 72.256737 1.627585 1.798399 0.923017
+GGGATT 73.783212 1.751142 2.053992 1.126623
+GGGCAA 74.186388 1.649132 1.693699 0.843597
+GGGCAC 73.239056 1.684494 1.663212 0.820922
+GGGCAG 73.616919 1.570759 1.571066 0.753654
+GGGCAT 74.160203 1.599733 1.695304 0.844797
+GGGCCA 67.993372 1.441251 1.093244 0.437478
+GGGCCC 66.698531 1.170315 1.150215 0.472116
+GGGCCG 67.875573 1.132005 1.055764 0.415175
+GGGCCT 68.105624 0.970747 1.140696 0.466268
+GGGCGA 74.00845 1.557652 1.564469 0.748912
+GGGCGC 72.757165 1.69827 1.578785 0.759215
+GGGCGG 72.697393 1.42801 1.589322 0.766829
+GGGCGT 72.792718 1.70096 1.801093 0.925092
+GGGCTA 70.940145 1.457027 1.482862 0.691085
+GGGCTC 70.446064 1.404283 1.50549 0.706964
+GGGCTG 70.239902 1.439445 1.571665 0.754085
+GGGCTT 71.024914 1.794689 1.905812 1.006933
+GGGGAA 72.156649 1.798096 1.522831 0.719214
+GGGGAC 69.668197 1.44793 1.437827 0.659843
+GGGGAG 71.44606 1.939047 1.566905 0.750662
+GGGGAT 71.204811 1.462117 1.641139 0.804635
+GGGGCA 63.279191 1.458264 1.384038 0.623164
+GGGGCC 62.532833 1.391686 1.390908 0.62781
+GGGGCG 63.326085 1.562702 1.382533 0.622148
+GGGGCT 63.979009 1.383481 1.388106 0.625914
+GGGGGA 69.753566 1.542456 1.374969 0.61705
+GGGGGC 68.493406 1.725746 1.511433 0.711155
+GGGGGG 69.221143 1.92478 1.37221 0.615193
+GGGGGT 69.834887 1.610146 1.51216 0.711668
+GGGGTA 67.25503 1.985488 1.615449 0.785815
+GGGGTC 66.83296 2.096281 1.771852 0.902655
+GGGGTG 67.010905 1.905452 1.613958 0.784727
+GGGGTT 67.866406 2.197355 1.848118 0.961557
+GGGTAA 56.682129 2.020638 1.515017 0.713686
+GGGTAC 55.25132 1.962596 1.507291 0.708233
+GGGTAG 56.426994 2.047617 1.500164 0.703216
+GGGTAT 56.370707 1.85318 1.482528 0.690852
+GGGTCA 49.300695 2.197355 1.90883 1.009326
+GGGTCC 47.790788 2.197355 1.797894 0.922628
+GGGTCG 49.486539 2.197355 1.893929 0.99753
+GGGTCT 49.246413 2.039178 1.843515 0.957967
+GGGTGA 55.83273 2.197355 1.504526 0.706285
+GGGTGC 55.310051 2.0179 1.64613 0.808308
+GGGTGG 54.722871 2.197355 1.4641 0.678011
+GGGTGT 55.828968 2.197355 1.480611 0.689512
+GGGTTA 50.474214 2.197355 1.736835 0.876029
+GGGTTC 49.10123 2.197355 2.060387 1.131889
+GGGTTG 51.020891 2.197355 1.765165 0.89755
+GGGTTT 50.690403 2.197355 1.940386 1.034458
+GGTAAA 62.969162 1.399513 1.144532 0.468622
+GGTAAC 62.113668 0.887708 0.954925 0.357137
+GGTAAG 62.832471 1.503227 1.177549 0.489046
+GGTAAT 63.652446 1.142275 1.15185 0.473123
+GGTACA 57.96713 1.039668 1.027698 0.39873
+GGTACC 57.265978 0.868078 0.920896 0.338218
+GGTACG 57.768196 1.141177 1.028399 0.399138
+GGTACT 58.073834 1.071457 1.018089 0.393151
+GGTAGA 62.74591 1.29062 1.213328 0.511503
+GGTAGC 62.440031 0.887878 1.055814 0.415204
+GGTAGG 62.465063 1.428411 1.128395 0.458746
+GGTAGT 63.670795 0.933213 1.194255 0.499489
+GGTATA 60.067934 0.88954 0.948817 0.353716
+GGTATC 59.290067 1.006768 1.041934 0.407044
+GGTATG 59.833596 0.882802 0.980391 0.371518
+GGTATT 60.043116 1.071549 1.228775 0.521302
+GGTCAA 57.758269 2.134474 1.442425 0.66301
+GGTCAC 57.083712 2.124615 1.303954 0.569868
+GGTCAG 57.007672 2.197355 1.460355 0.675411
+GGTCAT 57.779414 2.197355 1.48472 0.692385
+GGTCCA 53.893992 1.765289 1.424356 0.650591
+GGTCCC 53.373265 1.266445 1.328383 0.585957
+GGTCCG 53.579888 1.775881 1.32075 0.580914
+GGTCCT 53.471443 1.738524 1.273628 0.550104
+GGTCGA 57.188204 2.12187 1.419503 0.647269
+GGTCGC 56.56115 1.929956 1.278974 0.553571
+GGTCGG 56.089204 2.062355 1.413503 0.64317
+GGTCGT 56.607851 2.133635 1.484094 0.691947
+GGTCTA 55.832548 1.379786 1.209883 0.509326
+GGTCTC 54.222093 1.936329 1.065543 0.420956
+GGTCTG 54.234108 1.747274 1.146774 0.469999
+GGTCTT 55.461406 1.452299 1.185074 0.493741
+GGTGAA 56.37384 1.225113 1.215322 0.512764
+GGTGAC 54.661093 0.943722 0.952339 0.355687
+GGTGAG 56.008441 1.163268 1.19416 0.49943
+GGTGAT 55.955208 1.061257 1.175731 0.487913
+GGTGCA 51.335724 0.975387 1.419465 0.647243
+GGTGCC 50.615512 0.966927 1.216303 0.513385
+GGTGCG 51.182231 0.985748 1.316198 0.577913
+GGTGCT 51.450925 0.97416 1.183203 0.492572
+GGTGGA 56.082625 1.185986 1.146903 0.470079
+GGTGGC 55.66743 0.861943 0.948346 0.353452
+GGTGGG 55.705841 1.064647 1.018361 0.393308
+GGTGGT 56.54783 0.980791 1.055128 0.4148
+GGTGTA 53.686621 0.836925 0.958891 0.359364
+GGTGTC 53.002553 1.049016 1.084576 0.432285
+GGTGTG 53.634942 0.868001 0.949525 0.354112
+GGTGTT 54.01039 0.934898 1.070568 0.423938
+GGTTAA 49.891716 1.033693 1.17619 0.488199
+GGTTAC 49.201262 0.832013 1.058603 0.41685
+GGTTAG 49.589647 1.144407 1.249203 0.534355
+GGTTAT 49.513194 0.785717 1.047766 0.410466
+GGTTCA 44.722589 1.005816 1.435249 0.658069
+GGTTCC 43.714051 0.94509 1.312276 0.575332
+GGTTCG 44.546992 1.001018 1.413908 0.643446
+GGTTCT 44.402939 0.939628 1.214751 0.512403
+GGTTGA 48.906268 1.053516 1.143324 0.46788
+GGTTGC 48.299948 0.843693 0.932117 0.344418
+GGTTGG 48.408667 0.963576 1.053478 0.413827
+GGTTGT 48.563929 0.894764 0.925522 0.340769
+GGTTTA 45.33607 0.949604 1.04768 0.410415
+GGTTTC 44.176657 1.042447 1.030878 0.400582
+GGTTTG 44.982798 0.871731 0.938464 0.347942
+GGTTTT 45.083795 1.1338 0.960814 0.360445
+GTAAAA 65.772399 0.713541 0.872876 0.312111
+GTAAAC 63.179588 0.91135 1.0475 0.41031
+GTAAAG 65.154192 0.714688 0.870624 0.310904
+GTAAAT 64.992019 0.717395 1.008841 0.387806
+GTAACA 58.899677 0.794487 0.8501 0.299975
+GTAACC 57.956139 0.941229 0.885118 0.3187
+GTAACG 58.650178 0.840254 0.86641 0.30865
+GTAACT 59.205799 1.075487 0.851957 0.300959
+GTAAGA 66.844835 0.868936 0.921798 0.338715
+GTAAGC 65.446984 0.827407 1.048593 0.410952
+GTAAGG 66.159553 0.712328 0.853339 0.301692
+GTAAGT 66.415487 0.828746 1.13987 0.465762
+GTAATA 62.981377 0.879077 1.053052 0.413576
+GTAATC 62.274199 0.988499 1.120342 0.453844
+GTAATG 62.82353 0.886111 1.112692 0.449203
+GTAATT 63.557224 0.932671 1.263134 0.543319
+GTACAA 65.507537 1.39427 1.066905 0.421764
+GTACAC 64.98715 1.117519 0.958312 0.359039
+GTACAG 65.1265 1.368488 1.139577 0.465582
+GTACAT 65.446639 1.363329 1.151316 0.472795
+GTACCA 61.172028 0.982442 0.914581 0.334745
+GTACCC 60.362891 0.751499 0.802993 0.27539
+GTACCG 60.831086 0.926695 0.905987 0.330038
+GTACCT 60.955274 0.878251 0.804369 0.276098
+GTACGA 64.87223 1.327561 1.181419 0.491458
+GTACGC 64.440055 1.086315 0.940949 0.349325
+GTACGG 64.195093 1.126991 1.053902 0.414077
+GTACGT 64.484179 1.501138 1.055549 0.415048
+GTACTA 63.252093 0.778277 0.781278 0.264295
+GTACTC 62.266753 1.029574 0.944727 0.351431
+GTACTG 62.578134 0.890539 0.925898 0.340977
+GTACTT 62.861141 1.088063 1.209149 0.508862
+GTAGAA 65.201314 0.908163 0.986393 0.374935
+GTAGAC 63.134062 0.902591 1.045907 0.409374
+GTAGAG 64.633603 0.867768 0.996368 0.380636
+GTAGAT 64.552551 0.753557 1.114912 0.450549
+GTAGCA 59.436589 0.729992 1.023233 0.396134
+GTAGCC 58.376627 0.8026 0.952581 0.355822
+GTAGCG 59.365769 0.824987 1.037581 0.404496
+GTAGCT 59.675367 0.676586 0.938746 0.348099
+GTAGGA 64.804093 0.847918 0.959445 0.359675
+GTAGGC 63.401194 0.702401 1.025227 0.397293
+GTAGGG 64.408526 0.829241 0.92635 0.341227
+GTAGGT 64.723708 0.872322 1.089425 0.435188
+GTAGTA 62.158003 0.88185 1.066497 0.421522
+GTAGTC 60.680055 1.123225 1.188187 0.495687
+GTAGTG 62.132765 0.873286 1.128063 0.458544
+GTAGTT 62.313362 1.077143 1.246895 0.532875
+GTATAA 58.961416 0.864389 0.87107 0.311143
+GTATAC 57.530057 0.800483 0.816678 0.28246
+GTATAG 58.507464 0.966701 0.929336 0.342878
+GTATAT 58.326671 0.729701 0.83136 0.290111
+GTATCA 53.412322 1.099901 1.121549 0.454578
+GTATCC 52.035879 0.989004 1.054081 0.414182
+GTATCG 53.210606 1.062061 1.084115 0.43201
+GTATCT 52.983162 0.966365 0.993397 0.378935
+GTATGA 57.865216 1.088587 0.986936 0.375244
+GTATGC 55.671323 1.266705 1.180007 0.490577
+GTATGG 57.038307 1.192283 0.870561 0.310871
+GTATGT 56.478647 1.013254 0.888499 0.320528
+GTATTA 53.269063 1.246675 1.152697 0.473645
+GTATTC 51.35719 1.582435 1.351536 0.601343
+GTATTG 53.00045 1.363465 1.06156 0.418598
+GTATTT 52.711353 1.416438 1.167378 0.482723
+GTCAAA 65.126498 0.837847 1.025942 0.397708
+GTCAAC 62.824814 0.899493 1.118131 0.452501
+GTCAAG 64.833083 0.756083 1.272881 0.54962
+GTCAAT 64.826054 0.77814 1.047586 0.41036
+GTCACA 61.676838 0.716143 0.987795 0.375734
+GTCACC 60.69077 0.791421 0.952864 0.355981
+GTCACG 61.378677 0.73505 0.97076 0.366057
+GTCACT 61.655701 0.695955 0.937358 0.347327
+GTCAGA 67.079563 1.126566 1.247476 0.533247
+GTCAGC 65.515418 1.222841 1.270985 0.548392
+GTCAGG 66.651702 0.967606 1.10959 0.447326
+GTCAGT 66.811983 1.150262 1.340901 0.594259
+GTCATA 64.753961 0.974528 1.110079 0.447622
+GTCATC 63.946555 0.992463 1.268246 0.546621
+GTCATG 64.545425 1.039957 1.191763 0.497927
+GTCATT 64.883649 1.152312 1.546869 0.73631
+GTCCAA 64.717071 2.135278 1.426217 0.651867
+GTCCAC 64.039297 1.642274 1.21426 0.512092
+GTCCAG 64.085762 2.030315 1.553285 0.740896
+GTCCAT 64.179646 1.914847 1.464274 0.678132
+GTCCCA 61.395759 1.739067 1.231864 0.523269
+GTCCCC 60.444058 1.599842 1.092304 0.436914
+GTCCCG 60.584757 1.818986 1.250604 0.535255
+GTCCCT 61.144582 1.684042 1.236654 0.526324
+GTCCGA 63.785374 2.197355 1.459696 0.674954
+GTCCGC 63.250118 2.171316 1.249657 0.534647
+GTCCGG 63.841345 1.94363 1.521477 0.718255
+GTCCGT 63.457038 2.163973 1.648509 0.810061
+GTCCTA 62.078768 2.164358 1.17604 0.488106
+GTCCTC 61.880524 1.350138 1.173457 0.486498
+GTCCTG 62.483191 1.510341 1.26016 0.541401
+GTCCTT 62.311937 1.494179 1.46469 0.678421
+GTCGAA 65.900002 1.490602 1.297245 0.565475
+GTCGAC 64.604895 0.809686 0.945172 0.351679
+GTCGAG 65.637039 1.285576 1.293086 0.562758
+GTCGAT 65.49722 1.422253 1.337366 0.591911
+GTCGCA 61.471524 1.009411 1.038697 0.405148
+GTCGCC 60.621336 0.851199 0.93551 0.346301
+GTCGCG 61.275381 0.982806 1.042765 0.407531
+GTCGCT 61.609518 1.037576 1.021082 0.394886
+GTCGGA 64.632744 1.478045 1.16563 0.481639
+GTCGGC 63.536271 1.333447 1.337273 0.591848
+GTCGGG 64.665082 1.129824 1.199043 0.502496
+GTCGGT 64.73436 1.286064 1.367063 0.611735
+GTCGTA 62.400727 1.026863 1.297649 0.56574
+GTCGTC 61.000067 1.078963 1.413133 0.642918
+GTCGTG 62.222559 1.106864 1.304939 0.570513
+GTCGTT 62.335382 1.061865 1.491398 0.697061
+GTCTAA 60.157905 0.855761 0.906877 0.330524
+GTCTAC 58.989675 0.688929 0.814857 0.281516
+GTCTAG 60.37786 1.067965 1.109811 0.44746
+GTCTAT 59.660531 0.768018 0.833614 0.291292
+GTCTCA 55.930144 0.709307 1.0215 0.395128
+GTCTCC 55.043182 0.729504 0.900006 0.326775
+GTCTCG 55.729755 0.664415 1.016516 0.39224
+GTCTCT 55.661927 0.607256 0.914877 0.334908
+GTCTGA 58.24048 0.800228 0.954744 0.357035
+GTCTGC 56.585259 0.945121 1.132094 0.461004
+GTCTGG 57.731098 0.729397 0.851802 0.300877
+GTCTGT 57.397429 0.783255 0.961782 0.360991
+GTCTTA 54.888089 0.965893 1.007795 0.387203
+GTCTTC 53.110734 1.610595 1.273638 0.55011
+GTCTTG 54.682068 0.961431 0.966208 0.363485
+GTCTTT 54.373709 1.208769 1.128086 0.458558
+GTGAAA 73.164906 1.915263 1.927607 1.024256
+GTGAAC 69.988645 2.075133 1.848448 0.961815
+GTGAAG 72.783067 1.975722 1.934328 1.029618
+GTGAAT 72.462724 2.197355 2.101983 1.166338
+GTGACA 61.732498 1.44956 1.067091 0.421874
+GTGACC 61.226449 0.987235 1.044439 0.408512
+GTGACG 61.540333 1.471571 1.021099 0.394896
+GTGACT 62.646885 1.136496 1.103657 0.443743
+GTGAGA 71.782656 2.152364 2.000043 1.082529
+GTGAGC 68.807506 2.095606 1.747805 0.884342
+GTGAGG 70.951066 1.883563 1.901241 1.003313
+GTGAGT 71.116433 2.069339 2.071851 1.141349
+GTGATA 65.715065 1.796991 1.586027 0.764445
+GTGATC 65.152282 1.491398 1.610586 0.78227
+GTGATG 65.441649 1.847932 1.617614 0.787395
+GTGATT 66.519479 2.112574 1.919511 1.017809
+GTGCAA 70.449082 2.197355 2.108053 1.171394
+GTGCAC 69.236994 2.197355 2.00855 1.089443
+GTGCAG 69.193085 2.197355 1.99626 1.07946
+GTGCAT 69.864689 2.197355 2.130902 1.19049
+GTGCCA 63.224019 2.197355 1.583151 0.762367
+GTGCCC 62.830255 2.197355 1.463678 0.677718
+GTGCCG 62.714806 2.197355 1.606557 0.779336
+GTGCCT 63.627312 2.197355 1.537964 0.729962
+GTGCGA 69.712817 2.197355 1.991675 1.075743
+GTGCGC 68.481373 2.197355 1.957341 1.048046
+GTGCGG 68.678463 2.197355 1.985656 1.07087
+GTGCGT 68.938719 2.197355 2.110304 1.17327
+GTGCTA 66.687249 2.197355 1.625775 0.793362
+GTGCTC 65.884197 2.197355 1.821517 0.940872
+GTGCTG 65.886655 2.197355 1.826356 0.944623
+GTGCTT 66.295674 2.197355 2.11387 1.176246
+GTGGAA 65.368124 1.761638 1.568573 0.751862
+GTGGAC 62.334425 0.93548 1.075746 0.427017
+GTGGAG 64.615604 1.689742 1.490809 0.696648
+GTGGAT 64.608738 1.352327 1.495891 0.700214
+GTGGCA 57.742566 0.981539 1.207267 0.507675
+GTGGCC 56.630407 0.781727 1.024786 0.397037
+GTGGCG 57.516352 0.978686 1.184406 0.493324
+GTGGCT 58.139567 1.00553 1.130566 0.46007
+GTGGGA 63.449514 1.388925 1.361498 0.608004
+GTGGGC 60.895349 0.802264 1.169627 0.484119
+GTGGGG 62.500925 1.219667 1.161172 0.478879
+GTGGGT 63.11119 1.090221 1.260566 0.541663
+GTGGTA 60.906759 0.983302 1.23114 0.522807
+GTGGTC 59.252208 1.04758 1.439503 0.660997
+GTGGTG 60.573201 1.004073 1.227656 0.52059
+GTGGTT 61.20588 1.003051 1.43395 0.657176
+GTGTAA 51.707683 0.977906 1.081322 0.430342
+GTGTAC 50.310592 0.794917 1.095169 0.438634
+GTGTAG 51.284038 1.141781 1.161684 0.479196
+GTGTAT 51.27203 0.773605 0.990462 0.377257
+GTGTCA 45.195438 1.221458 1.496556 0.70068
+GTGTCC 44.196445 1.272195 1.478135 0.687783
+GTGTCG 44.941914 1.289982 1.448971 0.667529
+GTGTCT 44.740315 1.052215 1.340192 0.593788
+GTGTGA 50.546954 1.026677 1.020909 0.394785
+GTGTGC 49.245584 0.950435 1.101383 0.442372
+GTGTGG 49.708577 1.012266 1.037952 0.404712
+GTGTGT 49.741061 0.851403 0.954437 0.356863
+GTGTTA 45.927977 0.919011 1.087687 0.434147
+GTGTTC 44.721694 1.138612 1.284315 0.557042
+GTGTTG 45.637917 1.003435 0.998493 0.381855
+GTGTTT 45.853933 1.101182 1.075191 0.426687
+GTTAAA 62.754998 2.076978 1.538475 0.730325
+GTTAAC 61.924132 1.24423 1.287579 0.559167
+GTTAAG 62.909953 1.976416 1.566292 0.750222
+GTTAAT 63.174493 2.088837 1.519264 0.716689
+GTTACA 57.975876 1.618134 1.325616 0.584127
+GTTACC 57.269229 1.526887 1.164843 0.481151
+GTTACG 57.95114 1.582923 1.255565 0.538443
+GTTACT 58.126192 1.696744 1.237447 0.52683
+GTTAGA 62.794052 2.197355 1.738686 0.87743
+GTTAGC 62.421161 1.277531 1.43352 0.65688
+GTTAGG 62.316754 2.020528 1.550767 0.739095
+GTTAGT 63.272447 2.001797 1.644535 0.807134
+GTTATA 60.575948 1.164978 1.261505 0.542268
+GTTATC 59.435711 1.451528 1.279998 0.554236
+GTTATG 60.337882 1.283603 1.330574 0.587407
+GTTATT 60.330758 1.45104 1.482524 0.690849
+GTTCAA 58.674508 2.197355 1.714674 0.859317
+GTTCAC 57.758212 2.197355 1.593029 0.769514
+GTTCAG 58.232367 2.197355 1.708596 0.854751
+GTTCAT 58.703865 2.197355 1.792198 0.918247
+GTTCCA 54.820798 2.197355 1.537854 0.729883
+GTTCCC 53.881197 2.197355 1.496458 0.700611
+GTTCCG 54.430912 2.197355 1.557042 0.743586
+GTTCCT 54.085282 2.197355 1.551003 0.739264
+GTTCGA 58.424806 2.197355 1.744935 0.882165
+GTTCGC 57.417814 2.197355 1.600611 0.775013
+GTTCGG 57.44627 2.197355 1.713874 0.858715
+GTTCGT 57.72062 2.197355 1.789285 0.91601
+GTTCTA 56.44146 2.197355 1.490732 0.696594
+GTTCTC 55.7683 2.197355 1.363844 0.609576
+GTTCTG 55.73632 2.197355 1.474035 0.684924
+GTTCTT 56.227562 2.197355 1.479794 0.688942
+GTTGAA 55.575172 1.601508 1.44493 0.664739
+GTTGAC 53.535791 1.055567 0.929707 0.343083
+GTTGAG 54.953113 1.434676 1.294307 0.563555
+GTTGAT 54.723693 1.427752 1.22681 0.520052
+GTTGCA 50.511577 1.063566 1.397278 0.632128
+GTTGCC 49.532221 0.983486 1.12424 0.456215
+GTTGCG 50.369242 1.074258 1.370935 0.614336
+GTTGCT 50.398921 1.104657 1.138989 0.465222
+GTTGGA 55.497893 1.787004 1.358415 0.60594
+GTTGGC 54.667421 1.303254 1.045506 0.409138
+GTTGGG 55.254929 1.616782 1.157747 0.476762
+GTTGGT 55.673669 1.669142 1.279621 0.553991
+GTTGTA 53.346632 1.039422 0.971744 0.366614
+GTTGTC 52.211025 1.085566 1.053684 0.413949
+GTTGTG 53.184534 1.07282 0.963651 0.362043
+GTTGTT 53.204028 1.258837 1.092214 0.43686
+GTTTAA 49.936578 1.277659 1.1378 0.464493
+GTTTAC 49.056408 0.949806 0.965083 0.362851
+GTTTAG 49.623114 1.274182 1.155449 0.475343
+GTTTAT 49.481146 1.046227 0.938124 0.347753
+GTTTCA 44.615977 0.868094 1.277557 0.552651
+GTTTCC 43.661803 0.709301 1.081123 0.430222
+GTTTCG 44.453459 0.864217 1.275387 0.551243
+GTTTCT 44.224669 0.763619 1.021113 0.394904
+GTTTGA 48.951416 1.096608 1.010028 0.388491
+GTTTGC 48.081661 0.777518 0.786477 0.266937
+GTTTGG 48.465553 0.998125 0.918518 0.336908
+GTTTGT 48.526155 0.810874 0.815785 0.281997
+GTTTTA 45.272386 0.715761 0.766788 0.256977
+GTTTTC 43.946987 0.700461 0.85994 0.305199
+GTTTTG 44.926281 0.604332 0.672954 0.21128
+GTTTTT 44.730809 0.51969 0.642184 0.196956
+TAAAAA 64.789632 0.807058 0.748936 0.248055
+TAAAAC 62.856991 0.706378 0.892675 0.32279
+TAAAAG 64.313384 0.752675 0.779795 0.263543
+TAAAAT 64.575536 0.708232 0.813079 0.280595
+TAAACA 57.761653 0.795167 0.887779 0.320138
+TAAACC 56.79841 1.04254 0.911614 0.333117
+TAAACG 57.574572 0.784849 0.903901 0.328898
+TAAACT 57.742571 0.636849 0.800813 0.274269
+TAAAGA 65.055024 1.2349 0.818563 0.283438
+TAAAGC 64.421265 1.010003 0.950869 0.354864
+TAAAGG 64.557135 0.929567 0.786505 0.266952
+TAAAGT 65.360275 0.747018 0.943695 0.350855
+TAAATA 61.889874 0.726897 0.861408 0.305981
+TAAATC 61.43866 0.862017 1.003878 0.384948
+TAAATG 61.711868 0.697967 0.892937 0.322933
+TAAATT 62.493927 0.732484 1.142181 0.467179
+TAACAA 61.505061 1.183824 0.770391 0.25879
+TAACAC 60.960332 1.017361 0.702104 0.225155
+TAACAG 60.888035 1.150477 0.788653 0.268046
+TAACAT 61.552144 1.043759 0.824708 0.286636
+TAACCA 57.185703 0.842614 0.854173 0.302134
+TAACCC 56.481741 0.698018 0.789671 0.268566
+TAACCG 56.930268 0.820033 0.843062 0.296258
+TAACCT 56.957163 0.807547 0.771453 0.259325
+TAACGA 60.972163 1.142544 0.804281 0.276053
+TAACGC 60.766984 0.934324 0.732568 0.239968
+TAACGG 60.364964 1.260929 0.808698 0.27833
+TAACGT 60.729198 1.049483 0.866293 0.308587
+TAACTA 59.161237 0.815573 0.688785 0.218779
+TAACTC 58.760304 0.768409 0.766071 0.256616
+TAACTG 58.946363 0.791825 0.733033 0.240196
+TAACTT 59.182488 0.722901 0.830861 0.28985
+TAAGAA 64.419455 0.854599 0.902493 0.32813
+TAAGAC 62.86567 0.726391 0.866362 0.308624
+TAAGAG 63.963359 0.87507 0.936731 0.346979
+TAAGAT 64.376578 0.816599 0.953298 0.356224
+TAAGCA 58.817338 1.204188 1.310137 0.573926
+TAAGCC 57.915378 1.159931 1.217393 0.514075
+TAAGCG 58.675056 1.201607 1.310297 0.574031
+TAAGCT 58.899028 1.128834 1.116949 0.451784
+TAAGGA 63.509494 0.760237 0.847379 0.298536
+TAAGGC 62.869043 0.700161 0.877807 0.31476
+TAAGGG 63.235808 0.749792 0.779213 0.263248
+TAAGGT 63.838726 0.648802 0.866381 0.308634
+TAAGTA 61.130755 0.866211 0.959079 0.359469
+TAAGTC 60.112477 1.045954 1.154561 0.474795
+TAAGTG 60.997543 0.878786 1.014364 0.390995
+TAAGTT 61.483758 0.955471 1.116646 0.4516
+TAATAA 56.69825 1.158654 1.097129 0.439812
+TAATAC 55.283036 0.809044 1.009664 0.388281
+TAATAG 56.548294 1.183858 1.16714 0.482576
+TAATAT 56.207946 0.927142 1.051285 0.412536
+TAATCA 51.423155 1.234002 1.449748 0.668066
+TAATCC 50.386156 1.04866 1.384716 0.623622
+TAATCG 51.342743 1.157561 1.396614 0.631677
+TAATCT 51.141164 1.082235 1.335929 0.590957
+TAATGA 55.55803 1.185856 1.020305 0.394435
+TAATGC 54.068509 1.043255 1.224039 0.518291
+TAATGG 54.628065 0.85473 0.960362 0.360191
+TAATGT 54.745201 1.209897 1.038245 0.404884
+TAATTA 51.886474 1.107207 1.353061 0.602361
+TAATTC 50.280633 1.335238 1.70091 0.84899
+TAATTG 51.661859 1.190849 1.321599 0.581474
+TAATTT 51.398153 1.294172 1.434644 0.657653
+TACAAA 67.546771 0.665874 0.858528 0.304447
+TACAAC 65.473142 1.029678 0.982101 0.37249
+TACAAG 66.917668 0.796234 0.844702 0.297123
+TACAAT 67.185574 0.737679 1.008949 0.387868
+TACACA 63.581926 0.674804 0.771882 0.259542
+TACACC 62.403051 0.671732 0.800569 0.274144
+TACACG 63.397581 0.714263 0.77283 0.26002
+TACACT 63.667514 0.606285 0.859594 0.305015
+TACAGA 69.154515 0.7881 0.888273 0.320406
+TACAGC 68.24899 0.7199 0.983375 0.373215
+TACAGG 68.594327 0.684939 0.795863 0.27173
+TACAGT 69.096609 0.706464 1.104675 0.444357
+TACATA 67.118017 0.649614 0.901032 0.327334
+TACATC 66.530198 0.729746 1.078906 0.4289
+TACATG 66.785456 0.727617 0.987705 0.375683
+TACATT 67.363598 0.769936 1.303896 0.569829
+TACCAA 65.917484 1.202416 0.849654 0.299739
+TACCAC 65.465139 0.881818 0.771287 0.259241
+TACCAG 65.514135 1.182806 0.833336 0.291146
+TACCAT 65.798038 1.207488 0.863947 0.307335
+TACCCA 62.6174 0.855303 0.677022 0.213199
+TACCCC 62.092931 0.79728 0.661285 0.205809
+TACCCG 62.463845 0.849172 0.696079 0.222264
+TACCCT 62.641349 0.860937 0.710733 0.229319
+TACCGA 65.803799 1.270037 0.798143 0.272899
+TACCGC 65.525646 1.017144 0.775314 0.261275
+TACCGG 65.117036 1.18618 0.850783 0.300337
+TACCGT 65.564818 1.233975 0.986937 0.375245
+TACCTA 64.396127 0.83353 0.709538 0.228741
+TACCTC 63.760771 0.82145 0.75643 0.251787
+TACCTG 63.9525 0.858687 0.788299 0.267866
+TACCTT 64.110471 0.908067 1.009031 0.387916
+TACGAA 67.929058 0.86971 0.828851 0.288799
+TACGAC 66.818666 0.586422 0.830083 0.289443
+TACGAG 67.733368 0.989221 0.801997 0.274878
+TACGAT 67.938914 0.976165 0.945335 0.35177
+TACGCA 63.128716 0.678629 0.877011 0.314332
+TACGCC 62.505354 0.677092 0.777606 0.262434
+TACGCG 63.130114 0.731324 0.86758 0.309275
+TACGCT 63.456796 0.752828 0.837658 0.293414
+TACGGA 66.760823 0.82885 0.813122 0.280617
+TACGGC 66.105427 0.727403 1.013303 0.390382
+TACGGG 66.574502 0.786837 0.774767 0.260998
+TACGGT 66.943878 0.798828 1.024083 0.396628
+TACGTA 64.483343 0.706138 1.012955 0.390181
+TACGTC 63.209625 1.049135 1.251491 0.535824
+TACGTG 64.404574 0.767097 1.045892 0.409365
+TACGTT 64.728258 0.84317 1.124542 0.456398
+TACTAA 61.46526 0.7284 0.728078 0.237765
+TACTAC 60.184341 0.559943 0.70034 0.224308
+TACTAG 61.103064 0.519703 0.729308 0.238368
+TACTAT 61.00706 0.548706 0.710423 0.229169
+TACTCA 57.034847 0.936083 1.009411 0.388135
+TACTCC 55.926853 0.731212 0.928026 0.342153
+TACTCG 56.917037 0.983091 1.020425 0.394505
+TACTCT 56.702146 0.943393 0.910872 0.33271
+TACTGA 59.658623 0.828994 0.857755 0.304037
+TACTGC 57.850368 1.151285 1.106145 0.445245
+TACTGG 59.182863 0.832486 0.783546 0.265447
+TACTGT 58.823785 0.86102 0.932365 0.344556
+TACTTA 56.323901 1.186205 1.087351 0.433945
+TACTTC 54.398446 1.43939 1.321449 0.581375
+TACTTG 55.919323 1.16794 1.015655 0.391742
+TACTTT 55.714504 1.193389 1.13988 0.465768
+TAGAAA 74.637763 1.540482 1.492121 0.697569
+TAGAAC 72.125003 1.374349 1.520558 0.717605
+TAGAAG 74.27171 1.501089 1.460235 0.675328
+TAGAAT 74.237141 1.644068 1.57465 0.756235
+TAGACA 63.46283 1.176367 0.816326 0.282278
+TAGACC 62.559481 1.020708 0.959683 0.359809
+TAGACG 63.374115 1.230988 0.844424 0.296976
+TAGACT 64.143968 1.140596 0.985421 0.374381
+TAGAGA 73.369211 1.62677 1.44722 0.666319
+TAGAGC 71.659362 1.377993 1.418749 0.646754
+TAGAGG 72.651325 1.581901 1.31139 0.574749
+TAGAGT 72.947608 1.601641 1.557474 0.743896
+TAGATA 68.383088 1.153685 1.230441 0.522362
+TAGATC 67.882891 1.042478 1.315725 0.577601
+TAGATG 68.28504 1.072299 1.303607 0.56964
+TAGATT 69.574549 1.169949 1.516585 0.714794
+TAGCAA 69.987371 1.642168 1.273504 0.550023
+TAGCAC 69.100497 1.378817 1.179006 0.489953
+TAGCAG 68.636341 2.067199 1.130903 0.460276
+TAGCAT 69.255386 1.933449 1.28765 0.559213
+TAGCCA 63.917083 1.236011 0.852108 0.301039
+TAGCCC 63.331466 1.184363 0.831755 0.290318
+TAGCCG 63.743398 1.245928 0.840051 0.294672
+TAGCCT 63.767173 1.33792 0.913213 0.333994
+TAGCGA 69.218591 1.897598 1.142495 0.467371
+TAGCGC 68.677208 1.490211 1.159252 0.477691
+TAGCGG 68.197297 1.90409 1.166251 0.482024
+TAGCGT 68.635948 1.524605 1.310392 0.574093
+TAGCTA 66.835779 1.324853 1.062812 0.419339
+TAGCTC 66.023433 1.3446 1.260242 0.541454
+TAGCTG 66.07326 1.433523 1.143741 0.468136
+TAGCTT 66.747407 1.512165 1.509183 0.709567
+TAGGAA 68.483963 1.405238 1.181899 0.491758
+TAGGAC 66.033699 0.884778 0.939977 0.348784
+TAGGAG 67.662702 1.476665 1.152062 0.473254
+TAGGAT 67.952522 1.326429 1.20934 0.508983
+TAGGCA 60.844507 0.948457 1.152806 0.473713
+TAGGCC 59.758925 0.857619 1.080497 0.429849
+TAGGCG 60.453379 0.928516 1.139132 0.465309
+TAGGCT 61.087419 0.974906 1.025034 0.397181
+TAGGGA 67.217357 1.186031 1.018956 0.393653
+TAGGGC 64.539331 1.024127 0.949705 0.354212
+TAGGGG 66.234134 1.165556 0.883473 0.317812
+TAGGGT 67.122424 0.932052 1.141248 0.466607
+TAGGTA 64.758683 1.132873 1.031496 0.400942
+TAGGTC 63.391529 0.916855 1.163357 0.480231
+TAGGTG 64.32523 0.949978 1.066927 0.421777
+TAGGTT 65.272194 1.064763 1.257997 0.540008
+TAGTAA 54.675 1.300369 1.344103 0.596389
+TAGTAC 53.258886 0.957446 1.268787 0.54697
+TAGTAG 54.266182 1.199347 1.315676 0.577569
+TAGTAT 54.142461 0.99409 1.239473 0.528124
+TAGTCA 47.898363 1.266901 1.733377 0.873414
+TAGTCC 46.689114 1.164941 1.634213 0.799546
+TAGTCG 47.438575 1.267295 1.616939 0.786903
+TAGTCT 47.489511 1.321724 1.545974 0.735672
+TAGTGA 53.383411 0.990104 1.139633 0.465616
+TAGTGC 52.176591 0.879187 1.42539 0.6513
+TAGTGG 52.633859 0.998759 1.209372 0.509003
+TAGTGT 52.52048 0.742615 1.173808 0.486717
+TAGTTA 48.706548 0.808833 1.371816 0.614928
+TAGTTC 47.342757 1.013326 1.711258 0.85675
+TAGTTG 48.256639 0.983495 1.29707 0.565361
+TAGTTT 48.492066 0.996012 1.553405 0.740982
+TATAAA 63.485263 1.081031 0.715363 0.231564
+TATAAC 62.560561 0.728883 0.705261 0.226676
+TATAAG 63.319961 1.069218 0.738715 0.242994
+TATAAT 63.659325 0.955476 0.876883 0.314263
+TATACA 58.42858 0.928294 0.758481 0.252812
+TATACC 58.122594 1.019213 0.697184 0.222793
+TATACG 58.336575 0.914586 0.734126 0.240734
+TATACT 58.872079 1.188532 0.731334 0.239361
+TATAGA 63.421319 1.195353 0.781043 0.264176
+TATAGC 62.957114 0.828555 0.830885 0.289863
+TATAGG 62.946473 1.100142 0.788167 0.267798
+TATAGT 64.045576 0.86338 0.912459 0.333581
+TATATA 60.651182 0.84095 0.688198 0.2185
+TATATC 60.242392 0.702003 0.824499 0.286527
+TATATG 60.62027 0.690823 0.746181 0.246687
+TATATT 60.906493 0.799125 0.951085 0.354985
+TATCAA 59.260414 1.512748 0.899182 0.326326
+TATCAC 58.87101 1.356796 0.805081 0.276465
+TATCAG 58.43621 1.547201 0.991524 0.377864
+TATCAT 59.065411 1.586492 1.042584 0.407425
+TATCCA 55.557784 1.281087 0.991429 0.37781
+TATCCC 55.033651 1.150179 0.865307 0.308061
+TATCCG 55.341794 1.153353 0.92445 0.340178
+TATCCT 55.357449 1.140918 0.848136 0.298937
+TATCGA 58.741581 1.609596 0.948501 0.353539
+TATCGC 58.752997 1.381855 0.857745 0.304031
+TATCGG 58.340551 1.401771 0.942179 0.35001
+TATCGT 58.691848 1.416071 1.094465 0.438211
+TATCTA 57.12181 1.060567 0.763699 0.255425
+TATCTC 56.780921 1.105235 0.765264 0.256211
+TATCTG 56.588239 1.170504 0.814334 0.281245
+TATCTT 57.118093 1.02145 0.913703 0.334263
+TATGAA 56.317081 0.953346 1.069184 0.423116
+TATGAC 54.28857 0.665737 0.901576 0.32763
+TATGAG 55.80212 0.93885 1.030577 0.400406
+TATGAT 55.560096 0.762085 0.939726 0.348644
+TATGCA 50.87025 0.922948 1.413839 0.643399
+TATGCC 50.034882 0.851992 1.307343 0.572091
+TATGCG 50.836056 0.911517 1.439393 0.660922
+TATGCT 50.855911 0.753155 1.178615 0.489709
+TATGGA 56.045935 0.953056 0.883574 0.317867
+TATGGC 55.661564 0.648539 0.794598 0.271083
+TATGGG 55.634166 0.853668 0.765259 0.256209
+TATGGT 56.443586 0.806307 0.819748 0.284054
+TATGTA 53.892838 0.711949 0.794001 0.270777
+TATGTC 53.13186 0.625448 0.981188 0.371971
+TATGTG 53.687677 0.666522 0.762604 0.254876
+TATGTT 54.135974 0.670251 0.939692 0.348625
+TATTAA 49.995436 0.873814 1.091238 0.436275
+TATTAC 49.324485 0.712735 1.004713 0.385428
+TATTAG 49.768715 0.793276 1.075539 0.426894
+TATTAT 49.653925 0.643797 0.926382 0.341245
+TATTCA 44.911804 1.025275 1.506095 0.70739
+TATTCC 44.028244 1.060621 1.447035 0.666192
+TATTCG 44.813625 0.994562 1.516439 0.714691
+TATTCT 44.63908 1.075318 1.380007 0.620444
+TATTGA 49.26705 0.875182 0.966974 0.363918
+TATTGC 48.478779 0.590489 0.8798 0.315832
+TATTGG 48.749648 0.792883 0.930877 0.343731
+TATTGT 48.776962 0.744166 0.900954 0.327291
+TATTTA 45.48694 0.77931 0.998451 0.381831
+TATTTC 44.061962 0.669129 1.096772 0.439598
+TATTTG 45.238345 0.804175 0.978463 0.370422
+TATTTT 44.891007 0.720121 0.898176 0.325779
+TCAAAA 64.699 0.84935 0.89458 0.323825
+TCAAAC 61.609805 0.700972 1.001438 0.383545
+TCAAAG 63.760389 0.764546 0.91003 0.33225
+TCAAAT 63.586052 0.705431 0.983014 0.37301
+TCAACA 58.260018 0.782589 1.002525 0.38417
+TCAACC 56.790657 0.663808 0.928712 0.342533
+TCAACG 57.945818 0.804388 0.987957 0.375827
+TCAACT 58.03409 0.650883 0.908248 0.331274
+TCAAGA 66.035579 0.913271 0.901165 0.327407
+TCAAGC 64.398232 0.819813 1.128489 0.458803
+TCAAGG 64.960084 1.010819 0.907284 0.330747
+TCAAGT 65.562228 0.859398 1.051811 0.412845
+TCAATA 62.53944 0.704849 1.016133 0.392018
+TCAATC 61.655859 0.833157 1.127235 0.458039
+TCAATG 62.199039 0.81898 1.108149 0.446455
+TCAATT 62.806785 0.758516 1.309027 0.573197
+TCACAA 65.946232 1.299937 0.919419 0.337404
+TCACAC 65.412104 0.934589 0.860304 0.305393
+TCACAG 65.688937 1.256294 0.901424 0.327548
+TCACAT 65.674025 1.305169 0.956935 0.358265
+TCACCA 62.979371 1.743643 0.835318 0.292185
+TCACCC 61.425078 1.109538 0.785277 0.266327
+TCACCG 62.840984 1.816106 0.835129 0.292086
+TCACCT 62.35194 1.36956 0.850251 0.300055
+TCACGA 65.700745 1.237828 0.873915 0.312669
+TCACGC 64.978313 0.955888 0.866931 0.308928
+TCACGG 64.892918 1.079934 0.89497 0.324036
+TCACGT 65.33529 1.041521 1.03422 0.402531
+TCACTA 63.748017 0.771609 0.791089 0.269289
+TCACTC 62.771995 1.119582 0.910916 0.332735
+TCACTG 63.282329 0.86745 0.88616 0.319263
+TCACTT 63.590228 0.880077 1.14228 0.467239
+TCAGAA 65.250475 1.044311 1.004452 0.385278
+TCAGAC 62.439264 1.049763 0.943872 0.350954
+TCAGAG 64.566709 0.962277 1.008911 0.387846
+TCAGAT 64.3576 0.81691 1.010415 0.388714
+TCAGCA 59.616579 1.2701 1.267733 0.546289
+TCAGCC 58.203091 0.98847 1.12387 0.455989
+TCAGCG 59.368968 1.180676 1.242307 0.529937
+TCAGCT 59.683795 1.152493 1.197536 0.501549
+TCAGGA 65.038945 0.799682 0.909052 0.331714
+TCAGGC 63.516392 0.912736 1.041845 0.406992
+TCAGGG 64.584603 0.798801 0.911688 0.333158
+TCAGGT 64.773676 0.735507 0.952563 0.355812
+TCAGTA 62.439372 1.138411 1.160042 0.47818
+TCAGTC 61.18587 1.492704 1.425091 0.651095
+TCAGTG 62.251539 1.061531 1.218906 0.515034
+TCAGTT 62.55763 1.18675 1.405614 0.637793
+TCATAA 60.213126 0.944598 0.906751 0.330456
+TCATAC 58.414414 1.052966 0.885131 0.318707
+TCATAG 59.842417 1.042821 0.918601 0.336954
+TCATAT 59.464546 0.84944 0.877899 0.314809
+TCATCA 54.91656 1.149367 1.24962 0.534623
+TCATCC 53.557988 1.05723 1.193921 0.49928
+TCATCG 54.745721 1.134985 1.228964 0.521422
+TCATCT 54.468919 1.02245 1.114503 0.450301
+TCATGA 58.956122 1.236673 1.077793 0.428236
+TCATGC 56.703578 1.352285 1.248138 0.533672
+TCATGG 57.981137 1.412566 1.018222 0.393228
+TCATGT 57.696161 1.26304 1.096252 0.439285
+TCATTA 54.608309 1.489997 1.374697 0.616866
+TCATTC 52.722994 2.007971 1.610898 0.782497
+TCATTG 54.504446 1.593827 1.271696 0.548852
+TCATTT 54.327457 1.688288 1.416198 0.64501
+TCCAAA 67.572149 0.674786 0.972422 0.366997
+TCCAAC 65.026022 0.911135 1.103962 0.443927
+TCCAAG 66.967933 0.632762 0.990688 0.377386
+TCCAAT 66.800829 0.88146 1.156074 0.475729
+TCCACA 63.647194 0.678067 0.874069 0.312751
+TCCACC 62.249463 0.762355 0.868954 0.31001
+TCCACG 63.392701 0.731699 0.870253 0.310705
+TCCACT 63.622614 0.905971 0.907174 0.330686
+TCCAGA 69.842219 0.847623 0.996655 0.380801
+TCCAGC 68.597819 0.751991 1.069972 0.423583
+TCCAGG 69.177064 0.76678 0.954418 0.356852
+TCCAGT 69.499644 0.883182 1.274426 0.550621
+TCCATA 67.496077 0.706499 1.027272 0.398482
+TCCATC 66.659724 0.830072 1.158565 0.477267
+TCCATG 67.288688 0.68258 1.120798 0.454121
+TCCATT 67.743437 0.863493 1.442316 0.662935
+TCCCAA 68.503878 1.09953 0.997474 0.38127
+TCCCAC 67.409309 0.85642 0.843915 0.296707
+TCCCAG 67.996359 1.320276 1.062061 0.418894
+TCCCAT 68.5889 1.183987 1.035767 0.403435
+TCCCCA 65.295736 0.968059 0.799882 0.273791
+TCCCCC 64.502147 0.871833 0.711499 0.22969
+TCCCCG 64.886878 0.945441 0.748022 0.247601
+TCCCCT 65.117775 0.806398 0.755318 0.251232
+TCCCGA 68.276291 1.397812 1.015428 0.391611
+TCCCGC 67.802962 0.910975 0.900555 0.327074
+TCCCGG 67.725415 1.265679 1.024257 0.396729
+TCCCGT 68.134756 1.040178 1.15291 0.473777
+TCCCTA 66.863077 0.827904 0.865419 0.30812
+TCCCTC 66.066308 0.82914 0.893787 0.323394
+TCCCTG 66.116812 0.954679 1.006697 0.386571
+TCCCTT 66.495232 1.029602 1.226314 0.519736
+TCCGAA 69.187257 0.874815 0.916322 0.335701
+TCCGAC 67.314318 0.787301 0.96996 0.365604
+TCCGAG 68.726331 0.903099 0.906431 0.33028
+TCCGAT 68.875178 0.782304 0.942193 0.350018
+TCCGCA 64.182063 0.753246 0.922196 0.338934
+TCCGCC 63.162491 0.666949 0.789818 0.26864
+TCCGCG 64.120549 0.828275 0.893148 0.323047
+TCCGCT 64.334209 0.738647 0.873619 0.31251
+TCCGGA 68.35718 0.89484 0.927932 0.342101
+TCCGGC 67.264789 0.854943 1.179901 0.490511
+TCCGGG 67.953883 0.848757 1.023385 0.396223
+TCCGGT 68.127265 0.873891 1.319226 0.579909
+TCCGTA 65.616045 0.987281 1.25164 0.53592
+TCCGTC 63.771614 1.716686 1.523007 0.719339
+TCCGTG 65.314198 1.096149 1.246838 0.532838
+TCCGTT 65.451875 1.334088 1.449991 0.668234
+TCCTAA 63.210299 0.711769 0.78225 0.264788
+TCCTAC 61.485171 0.757144 0.837576 0.293371
+TCCTAG 62.970333 0.548214 0.783824 0.265588
+TCCTAT 62.690244 0.811696 0.830297 0.289555
+TCCTCA 58.697726 0.864771 0.950596 0.354711
+TCCTCC 57.537363 0.699263 0.861672 0.306121
+TCCTCG 58.52755 0.853405 0.962928 0.361636
+TCCTCT 58.294992 0.702466 0.887619 0.320052
+TCCTGA 61.145707 1.023267 1.014595 0.391129
+TCCTGC 58.836322 1.387037 1.221374 0.516599
+TCCTGG 60.722267 0.921752 0.876189 0.31389
+TCCTGT 60.106042 1.053632 1.03389 0.402339
+TCCTTA 57.253474 1.305925 1.28951 0.560425
+TCCTTC 55.177758 1.767051 1.39076 0.62771
+TCCTTG 57.264759 1.312957 1.099532 0.441258
+TCCTTT 56.650529 1.619943 1.274145 0.550439
+TCGAAA 72.554588 1.279694 1.267452 0.546107
+TCGAAC 69.951146 0.928947 1.250995 0.535505
+TCGAAG 72.012294 1.24442 1.210183 0.509515
+TCGAAT 72.229137 1.32846 1.400648 0.634416
+TCGACA 62.938155 0.708152 0.815732 0.281969
+TCGACC 61.822699 0.665379 0.886301 0.319339
+TCGACG 62.664964 0.763298 0.814538 0.28135
+TCGACT 63.228797 0.683775 0.869747 0.310434
+TCGAGA 71.869527 1.354404 1.299065 0.566666
+TCGAGC 69.714763 0.909649 1.215427 0.51283
+TCGAGG 70.888128 1.281531 1.226766 0.520024
+TCGAGT 71.181885 1.177018 1.534836 0.727736
+TCGATA 66.875396 0.897023 1.086409 0.433382
+TCGATC 65.757315 1.263353 1.275167 0.551101
+TCGATG 66.543911 0.980356 1.159003 0.477537
+TCGATT 67.724874 1.081187 1.359603 0.606734
+TCGCAA 71.052961 1.524275 1.264874 0.544442
+TCGCAC 69.766479 1.420464 1.197442 0.50149
+TCGCAG 70.582098 1.695605 1.162854 0.47992
+TCGCAT 70.990126 1.54165 1.347682 0.598772
+TCGCCA 65.452046 1.388108 0.800408 0.274061
+TCGCCC 64.989225 0.958786 0.783238 0.26529
+TCGCCG 65.310568 1.185551 0.793635 0.27059
+TCGCCT 65.717967 1.18217 0.869085 0.31008
+TCGCGA 70.831054 1.719523 1.196243 0.500737
+TCGCGC 69.344267 1.488346 1.206831 0.5074
+TCGCGG 69.808311 1.507417 1.170965 0.484949
+TCGCGT 69.618323 1.681156 1.440227 0.661496
+TCGCTA 67.990221 1.310929 1.078318 0.428549
+TCGCTC 67.153769 1.24347 1.126692 0.457708
+TCGCTG 67.317906 1.336283 1.19749 0.50152
+TCGCTT 67.668483 1.433911 1.499386 0.702669
+TCGGAA 63.728809 1.092024 1.136003 0.463394
+TCGGAC 59.894703 0.912972 1.137549 0.46434
+TCGGAG 62.687681 1.192335 1.209278 0.508944
+TCGGAT 62.50107 0.992113 1.207383 0.507748
+TCGGCA 56.435067 1.397817 1.582868 0.762163
+TCGGCC 55.057947 1.218209 1.470638 0.682557
+TCGGCG 56.049764 1.29807 1.474139 0.684997
+TCGGCT 56.561702 1.164803 1.407335 0.638965
+TCGGGA 61.732543 1.163011 1.164678 0.481049
+TCGGGC 58.893368 1.509116 1.325441 0.584011
+TCGGGG 60.984367 1.181401 1.208428 0.508407
+TCGGGT 61.230584 1.023025 1.285478 0.557799
+TCGGTA 58.45044 1.59112 1.439198 0.660787
+TCGGTC 56.634138 2.102477 1.638785 0.802904
+TCGGTG 58.538828 1.538647 1.322879 0.582319
+TCGGTT 58.627094 1.810236 1.584681 0.763472
+TCGTAA 49.803875 1.724393 1.79979 0.924088
+TCGTAC 48.186274 1.255777 1.714897 0.859484
+TCGTAG 49.444084 1.730073 1.933226 1.028738
+TCGTAT 49.234657 1.492895 1.784844 0.912601
+TCGTCA 43.3253 1.758413 2.248874 1.290709
+TCGTCC 41.885628 1.509994 2.059466 1.13113
+TCGTCG 43.067141 1.74503 2.115497 1.177604
+TCGTCT 42.760095 1.561231 1.998624 1.081377
+TCGTGA 48.248381 1.290863 1.67362 0.82864
+TCGTGC 46.627256 1.101159 1.620818 0.789736
+TCGTGG 47.447458 1.397409 1.699285 0.847774
+TCGTGT 47.363295 1.277308 1.644891 0.807396
+TCGTTA 43.996567 1.154691 1.760787 0.894213
+TCGTTC 42.653625 1.560754 1.842728 0.957354
+TCGTTG 43.578067 1.124522 1.66982 0.82582
+TCGTTT 43.733425 1.561348 1.684203 0.836512
+TCTAAA 66.0262 1.030878 0.870106 0.310627
+TCTAAC 64.464371 0.772966 0.804608 0.276222
+TCTAAG 66.125714 1.16917 0.904148 0.329033
+TCTAAT 66.183837 0.900604 0.906714 0.330435
+TCTACA 60.931585 0.940347 0.70752 0.227766
+TCTACC 60.196973 0.923683 0.651918 0.201451
+TCTACG 61.491038 1.711607 0.71663 0.232179
+TCTACT 61.237454 1.15463 0.767572 0.257371
+TCTAGA 66.696431 0.882436 0.912813 0.333775
+TCTAGC 65.393925 0.826909 0.926395 0.341252
+TCTAGG 66.362495 1.151813 0.801703 0.274727
+TCTAGT 65.802997 1.186198 1.027066 0.398362
+TCTATA 62.810709 0.802767 0.755447 0.251297
+TCTATC 62.08362 0.700761 0.852704 0.301355
+TCTATG 62.453479 0.832822 0.804262 0.276043
+TCTATT 63.035049 0.885772 1.096626 0.439509
+TCTCAA 62.934744 1.657204 0.879221 0.315521
+TCTCAC 62.501081 1.51547 0.800154 0.273931
+TCTCAG 62.58331 1.474739 0.938883 0.348175
+TCTCAT 63.007784 1.525895 0.956238 0.357874
+TCTCCA 59.283272 1.22958 0.822129 0.285293
+TCTCCC 58.691652 1.17668 0.74182 0.244528
+TCTCCG 59.131615 1.277385 0.818917 0.283623
+TCTCCT 59.273585 1.190881 0.805016 0.276431
+TCTCGA 62.821461 1.594138 0.894858 0.323975
+TCTCGC 62.220929 1.419021 0.810916 0.279476
+TCTCGG 62.305758 1.439721 0.956625 0.358091
+TCTCGT 62.543297 1.545022 1.055854 0.415228
+TCTCTA 60.769619 1.213945 0.738361 0.24282
+TCTCTC 59.949451 0.904368 0.779137 0.26321
+TCTCTG 60.533362 1.068831 0.799337 0.273512
+TCTCTT 60.519821 1.070699 0.942322 0.35009
+TCTGAA 56.112264 1.059831 1.082563 0.431082
+TCTGAC 53.111401 0.925784 1.094839 0.438436
+TCTGAG 55.376262 0.937639 1.128809 0.458998
+TCTGAT 54.742344 0.892614 1.064888 0.420568
+TCTGCA 50.285095 1.010298 1.571068 0.753656
+TCTGCC 49.120393 1.03091 1.43141 0.655431
+TCTGCG 50.169464 1.040612 1.541605 0.732555
+TCTGCT 50.15757 0.99685 1.304035 0.569921
+TCTGGA 56.298204 0.904147 0.92312 0.339444
+TCTGGC 55.443522 0.617104 0.876598 0.314109
+TCTGGG 55.855654 0.812731 0.810914 0.279475
+TCTGGT 56.405218 0.75008 0.811097 0.27957
+TCTGTA 53.689475 0.654576 0.839777 0.294528
+TCTGTC 52.640303 0.714016 1.057393 0.416136
+TCTGTG 53.442804 0.611758 0.844052 0.29678
+TCTGTT 53.917196 0.677377 1.029193 0.3996
+TCTTAA 50.103801 0.997514 1.166494 0.482175
+TCTTAC 49.235372 0.832431 1.070121 0.423672
+TCTTAG 49.913696 0.858188 1.224484 0.518574
+TCTTAT 49.643067 0.710604 0.965606 0.363146
+TCTTCA 44.41873 1.198833 1.60307 0.7768
+TCTTCC 43.318284 1.191765 1.480629 0.689525
+TCTTCG 44.122155 1.102902 1.560814 0.74629
+TCTTCT 44.088444 1.173556 1.467866 0.680629
+TCTTGA 49.200365 0.947411 1.002627 0.384229
+TCTTGC 48.297043 0.643191 0.990617 0.377346
+TCTTGG 48.602508 0.81153 1.044871 0.408766
+TCTTGT 48.615093 0.681951 0.953671 0.356434
+TCTTTA 45.029693 0.836419 1.108294 0.446543
+TCTTTC 43.432605 0.64462 1.093171 0.437434
+TCTTTG 44.615745 0.789232 1.034625 0.402768
+TCTTTT 44.369918 0.656897 0.938727 0.348088
+TGAAAA 68.43878 1.105593 1.213902 0.511866
+TGAAAC 66.680683 1.419235 1.449752 0.668069
+TGAAAG 67.893814 1.137254 1.182943 0.49241
+TGAAAT 68.24316 1.275854 1.412964 0.642802
+TGAACA 60.368789 1.622306 1.276249 0.551803
+TGAACC 59.723543 1.621237 1.448172 0.666977
+TGAACG 60.007574 1.571411 1.233518 0.524323
+TGAACT 60.842912 1.494402 1.326858 0.584948
+TGAAGA 69.068739 1.244974 1.31191 0.575091
+TGAAGC 68.522877 1.56191 1.444041 0.664125
+TGAAGG 68.515008 1.182 1.234633 0.525034
+TGAAGT 69.078439 1.552071 1.566392 0.750294
+TGAATA 64.996448 1.510601 1.420364 0.647858
+TGAATC 64.578088 1.637092 1.57195 0.754291
+TGAATG 64.795205 1.559827 1.459627 0.674906
+TGAATT 65.966575 1.467664 1.639982 0.803784
+TGACAA 63.11782 0.819985 0.852189 0.301082
+TGACAC 63.047428 0.816264 0.813817 0.280977
+TGACAG 62.756765 0.842079 0.883658 0.317912
+TGACAT 63.375098 0.751787 0.893838 0.323421
+TGACCA 58.678539 0.682353 0.86227 0.30644
+TGACCC 57.854487 0.671971 0.833916 0.29145
+TGACCG 58.373559 0.690281 0.856389 0.30331
+TGACCT 58.563511 0.659283 0.811529 0.279793
+TGACGA 62.883886 0.962432 0.813287 0.280702
+TGACGC 62.27972 0.795483 0.8597 0.305071
+TGACGG 62.029336 0.81015 0.845781 0.297692
+TGACGT 62.259098 0.801564 0.92861 0.342476
+TGACTA 60.869098 0.595911 0.771632 0.259416
+TGACTC 60.231193 0.657163 0.914453 0.334675
+TGACTG 60.322085 0.663405 0.834418 0.291713
+TGACTT 60.790192 0.812804 1.09058 0.43588
+TGAGAA 67.018635 1.290116 1.233974 0.524614
+TGAGAC 65.307677 1.107266 1.209273 0.508941
+TGAGAG 66.684559 1.268904 1.244053 0.531055
+TGAGAT 66.924326 1.020201 1.250088 0.534924
+TGAGCA 60.454697 1.332447 1.477908 0.687625
+TGAGCC 59.433221 1.064702 1.293476 0.563013
+TGAGCG 60.340645 1.323912 1.446583 0.66588
+TGAGCT 60.476595 1.116223 1.331462 0.587995
+TGAGGA 66.001658 0.998735 1.153807 0.47433
+TGAGGC 65.407938 1.171052 1.335564 0.590715
+TGAGGG 65.28123 1.126465 1.101494 0.44244
+TGAGGT 66.448743 0.909603 1.275672 0.551429
+TGAGTA 63.223432 1.369194 1.308443 0.572813
+TGAGTC 62.228177 1.465053 1.574101 0.755839
+TGAGTG 63.123322 1.403051 1.454713 0.671501
+TGAGTT 63.653432 1.317598 1.619164 0.788528
+TGATAA 57.386428 1.112703 1.199324 0.502673
+TGATAC 55.885123 0.91611 1.127771 0.458366
+TGATAG 56.906032 1.115232 1.199646 0.502875
+TGATAT 56.834591 0.93063 1.1586 0.477288
+TGATCA 51.709037 1.285855 1.498274 0.701888
+TGATCC 50.223075 1.088126 1.444224 0.664251
+TGATCG 51.416409 1.226094 1.467938 0.680679
+TGATCT 51.16998 1.08632 1.388322 0.62606
+TGATGA 56.230392 1.332556 1.21729 0.51401
+TGATGC 54.877855 1.25508 1.460171 0.675283
+TGATGG 55.194439 1.197579 1.126754 0.457746
+TGATGT 55.426886 1.22197 1.268113 0.546535
+TGATTA 52.104028 1.398593 1.538606 0.730418
+TGATTC 50.414506 1.679611 1.794115 0.919721
+TGATTG 51.618228 1.352178 1.528441 0.723192
+TGATTT 51.877656 1.52438 1.611985 0.78329
+TGCAAA 68.39272 1.212349 1.335281 0.590527
+TGCAAC 66.187328 1.736192 1.468841 0.681307
+TGCAAG 67.984272 1.22536 1.32652 0.584724
+TGCAAT 67.989758 1.435171 1.506178 0.707449
+TGCACA 63.970609 1.097696 1.172051 0.485624
+TGCACC 63.244869 1.544799 1.255331 0.538292
+TGCACG 63.661915 1.057582 1.146374 0.469754
+TGCACT 64.371555 1.294152 1.197437 0.501487
+TGCAGA 70.600212 0.982768 1.278345 0.553163
+TGCAGC 69.927677 1.474455 1.477018 0.687004
+TGCAGG 69.842832 1.09374 1.287984 0.559431
+TGCAGT 70.345591 1.348587 1.719079 0.86263
+TGCATA 67.704469 1.242144 1.354655 0.603426
+TGCATC 67.004486 1.58353 1.477884 0.687609
+TGCATG 67.248879 1.483831 1.459673 0.674938
+TGCATT 67.969341 1.492353 1.793417 0.919184
+TGCCAA 67.130648 0.828137 0.975114 0.368522
+TGCCAC 66.478731 0.751157 1.009796 0.388357
+TGCCAG 66.640063 0.776696 0.9704 0.365853
+TGCCAT 67.188526 0.892649 1.0574 0.41614
+TGCCCA 64.115899 0.784944 0.972079 0.366803
+TGCCCC 63.236685 0.778893 0.936831 0.347034
+TGCCCG 63.761416 0.753385 0.961425 0.360789
+TGCCCT 63.914467 0.786552 0.949068 0.353856
+TGCCGA 66.939891 0.866737 0.927968 0.342121
+TGCCGC 66.546777 0.748506 0.973589 0.367658
+TGCCGG 66.196964 0.781229 0.979902 0.37124
+TGCCGT 66.635853 0.840751 1.113345 0.449599
+TGCCTA 65.508165 0.70388 1.018453 0.393362
+TGCCTC 64.957255 0.94166 1.095317 0.438723
+TGCCTG 65.050533 0.758919 1.119855 0.453548
+TGCCTT 65.404473 0.900944 1.368089 0.612424
+TGCGAA 69.627726 0.979579 1.173917 0.486785
+TGCGAC 68.312567 1.292168 1.291679 0.56184
+TGCGAG 69.112949 1.136074 1.230714 0.522536
+TGCGAT 69.65673 0.990493 1.346148 0.59775
+TGCGCA 64.301461 1.121758 1.191699 0.497887
+TGCGCC 63.263895 0.986756 1.049029 0.411209
+TGCGCG 63.997905 1.024878 1.18884 0.496096
+TGCGCT 64.340143 0.960354 1.124867 0.456596
+TGCGGA 68.144163 1.0783 1.242127 0.529822
+TGCGGC 67.569465 1.643348 1.54803 0.737139
+TGCGGG 67.762121 1.09073 1.382374 0.622041
+TGCGGT 68.283132 1.110707 1.645518 0.807857
+TGCGTA 64.914724 1.506546 1.625205 0.792944
+TGCGTC 63.591492 2.197355 1.829857 0.947341
+TGCGTG 64.565996 1.608854 1.659653 0.818288
+TGCGTT 65.084043 1.862101 1.865075 0.974822
+TGCTAA 62.312005 1.100639 1.089194 0.435049
+TGCTAC 60.787972 1.113581 1.080513 0.429859
+TGCTAG 62.100288 1.117837 1.144752 0.468757
+TGCTAT 61.741386 1.045244 1.039485 0.405609
+TGCTCA 57.529074 1.172703 1.295144 0.564102
+TGCTCC 56.292104 1.144281 1.266996 0.545812
+TGCTCG 57.413352 1.27945 1.326844 0.584939
+TGCTCT 57.140104 1.128804 1.289534 0.560441
+TGCTGA 60.437541 1.433983 1.265273 0.5447
+TGCTGC 58.605969 1.856397 1.558371 0.744538
+TGCTGG 59.88338 1.484704 1.158037 0.47694
+TGCTGT 59.36539 1.585742 1.339168 0.593107
+TGCTTA 56.861152 1.829384 1.55717 0.743677
+TGCTTC 54.928229 2.197355 1.80601 0.928883
+TGCTTG 56.93058 1.943334 1.481346 0.690026
+TGCTTT 56.355511 2.13211 1.589184 0.766729
+TGGAAA 77.918694 1.961384 1.870515 0.97909
+TGGAAC 75.211727 1.964522 1.974703 1.062021
+TGGAAG 77.615119 1.856658 1.851633 0.964302
+TGGAAT 77.685706 1.978822 2.11037 1.173325
+TGGACA 65.695636 1.215812 1.095883 0.439063
+TGGACC 64.664001 1.1123 1.213617 0.511686
+TGGACG 65.491383 1.136695 1.101189 0.442255
+TGGACT 66.194356 1.195993 1.298134 0.566057
+TGGAGA 76.653158 2.062349 1.880315 0.986794
+TGGAGC 74.592783 1.920434 1.840746 0.95581
+TGGAGG 75.675919 2.031955 1.763676 0.896414
+TGGAGT 76.181005 2.072248 2.119546 1.180986
+TGGATA 71.087752 1.401049 1.628936 0.795677
+TGGATC 70.690925 1.361418 1.776793 0.906433
+TGGATG 70.817618 1.507609 1.691736 0.842131
+TGGATT 72.372662 1.381336 1.954886 1.046075
+TGGCAA 72.662366 2.069449 1.771795 0.902611
+TGGCAC 71.769908 1.876271 1.711072 0.85661
+TGGCAG 72.057988 2.019887 1.663045 0.820798
+TGGCAT 72.350954 2.058671 1.800315 0.924492
+TGGCCA 66.212285 1.790883 1.144927 0.468865
+TGGCCC 65.58269 1.513414 1.16594 0.481831
+TGGCCG 65.778554 1.932422 1.128834 0.459014
+TGGCCT 66.255217 1.752357 1.201183 0.503842
+TGGCGA 72.012665 2.197355 1.647261 0.809141
+TGGCGC 70.83731 2.069275 1.678941 0.832595
+TGGCGG 70.94223 2.150682 1.65911 0.817887
+TGGCGT 70.989699 2.000942 1.842144 0.956899
+TGGCTA 69.309663 1.805824 1.507137 0.708125
+TGGCTC 68.363435 2.045835 1.604445 0.7778
+TGGCTG 68.555792 1.878237 1.634875 0.800032
+TGGCTT 68.896413 2.188723 1.919026 1.017424
+TGGGAA 69.209448 1.916728 1.519807 0.717073
+TGGGAC 65.905194 1.17146 1.223894 0.518199
+TGGGAG 68.164382 1.983224 1.481031 0.689806
+TGGGAT 68.010961 1.511601 1.449037 0.667575
+TGGGCA 59.51255 1.239335 1.261416 0.542211
+TGGGCC 58.685423 1.199864 1.181423 0.491461
+TGGGCG 59.39259 1.303888 1.249557 0.534583
+TGGGCT 60.242914 1.572463 1.253929 0.53739
+TGGGGA 67.497502 1.517187 1.329914 0.58697
+TGGGGC 65.653774 1.194798 1.288085 0.559496
+TGGGGG 66.757277 1.648451 1.302661 0.56902
+TGGGGT 67.280753 1.667052 1.390022 0.62721
+TGGGTA 65.400514 1.247675 1.348808 0.599523
+TGGGTC 64.426805 1.130357 1.468712 0.681217
+TGGGTG 65.062548 1.486904 1.40599 0.638049
+TGGGTT 65.905097 1.2808 1.652493 0.812999
+TGGTAA 55.22551 1.361744 1.239035 0.527844
+TGGTAC 53.857138 0.923707 1.182599 0.492195
+TGGTAG 54.828639 1.342921 1.22943 0.521719
+TGGTAT 54.745564 1.043082 1.231961 0.523331
+TGGTCA 47.881538 1.287613 1.660278 0.818751
+TGGTCC 46.796428 1.193298 1.599628 0.7743
+TGGTCG 47.64064 1.320451 1.60357 0.777164
+TGGTCT 47.43868 1.159193 1.484559 0.692272
+TGGTGA 54.013915 1.141028 1.149042 0.471394
+TGGTGC 53.211502 1.087186 1.283721 0.556655
+TGGTGG 53.162306 1.069066 1.160378 0.478387
+TGGTGT 53.243163 1.017729 1.100514 0.441849
+TGGTTA 49.056147 1.018873 1.297919 0.565916
+TGGTTC 47.775709 1.126238 1.602216 0.776179
+TGGTTG 48.613232 1.067451 1.272971 0.549678
+TGGTTT 48.866014 1.03628 1.497015 0.701003
+TGTAAA 61.006748 1.71487 1.159701 0.477969
+TGTAAC 60.734733 1.00109 1.022846 0.39591
+TGTAAG 60.696343 1.799689 1.23881 0.527701
+TGTAAT 61.36192 1.823927 1.201889 0.504287
+TGTACA 56.042567 1.401721 1.016332 0.392134
+TGTACC 55.604905 1.215345 0.875327 0.313427
+TGTACG 55.764382 1.463353 1.024371 0.396795
+TGTACT 56.326448 1.320604 0.946394 0.352362
+TGTAGA 60.78523 1.906608 1.246927 0.532896
+TGTAGC 60.75609 1.305203 1.129536 0.459442
+TGTAGG 60.231478 1.52568 1.129884 0.459654
+TGTAGT 60.866386 1.911415 1.234464 0.524926
+TGTATA 58.248849 1.556977 0.96112 0.360618
+TGTATC 57.988555 1.057111 1.018833 0.393582
+TGTATG 58.291306 1.318207 1.021094 0.394893
+TGTATT 58.661246 1.133533 1.149428 0.471632
+TGTCAA 55.752446 2.197355 1.361542 0.608033
+TGTCAC 55.200383 2.197355 1.204125 0.505694
+TGTCAG 54.884523 2.197355 1.344331 0.59654
+TGTCAT 55.71319 2.197355 1.397769 0.632461
+TGTCCA 52.000446 1.986582 1.302924 0.569193
+TGTCCC 51.224005 2.024314 1.296163 0.564768
+TGTCCG 51.480178 1.917984 1.321715 0.58155
+TGTCCT 51.449643 1.85434 1.196197 0.500709
+TGTCGA 54.502776 2.197355 1.454435 0.671308
+TGTCGC 55.082553 2.197355 1.273451 0.549989
+TGTCGG 53.963387 2.197355 1.364374 0.609931
+TGTCGT 54.793604 2.197355 1.530626 0.724744
+TGTCTA 53.844258 1.914028 1.184817 0.49358
+TGTCTC 52.968429 1.916688 1.13611 0.463459
+TGTCTG 52.642208 1.907388 1.138423 0.464875
+TGTCTT 53.054849 2.162844 1.203805 0.505492
+TGTGAA 53.991816 1.271259 1.188745 0.496037
+TGTGAC 52.319728 0.741643 0.880956 0.316455
+TGTGAG 53.561649 1.137969 1.07461 0.426341
+TGTGAT 53.563028 1.187864 1.057859 0.416411
+TGTGCA 48.766986 0.95854 1.406484 0.638385
+TGTGCC 47.984582 0.877496 1.194706 0.499773
+TGTGCG 48.62328 0.928299 1.312674 0.575594
+TGTGCT 48.787049 0.873447 1.119619 0.453405
+TGTGGA 54.002654 1.556383 1.15779 0.476788
+TGTGGC 53.685922 1.01143 0.850267 0.300064
+TGTGGG 53.610431 1.221426 0.986126 0.374782
+TGTGGT 54.363591 1.334936 1.011258 0.389201
+TGTGTA 52.186476 0.898185 0.90607 0.330083
+TGTGTC 51.134382 0.785041 0.910048 0.332259
+TGTGTG 51.828775 0.885753 0.839184 0.294216
+TGTGTT 52.033629 0.848791 0.924525 0.340219
+TGTTAA 48.202337 1.096795 1.10178 0.442612
+TGTTAC 47.537496 0.823122 1.030837 0.400558
+TGTTAG 47.846899 1.012272 1.12 0.453636
+TGTTAT 47.829592 0.895086 0.979277 0.370885
+TGTTCA 42.975028 0.727118 1.320351 0.580651
+TGTTCC 42.152353 0.710581 1.158285 0.477094
+TGTTCG 42.80823 0.719273 1.292913 0.562645
+TGTTCT 42.654961 0.656016 1.110996 0.448177
+TGTTGA 47.442388 1.177383 1.062049 0.418888
+TGTTGC 47.002491 0.849317 0.881869 0.316947
+TGTTGG 46.930574 1.250747 0.924201 0.34004
+TGTTGT 46.942434 0.8633 0.853647 0.301855
+TGTTTA 43.878044 0.73323 0.899211 0.326342
+TGTTTC 42.752796 0.571979 0.813493 0.280809
+TGTTTG 43.553019 0.65818 0.822585 0.28553
+TGTTTT 43.5335 0.559163 0.712725 0.230284
+TTAAAA 65.846913 0.753511 0.883639 0.317902
+TTAAAC 63.433841 0.804468 1.080977 0.430136
+TTAAAG 65.070634 0.853426 0.918312 0.336795
+TTAAAT 65.161294 0.719955 1.045124 0.408915
+TTAACA 59.333339 0.719622 0.840584 0.294952
+TTAACC 58.266991 0.864113 0.919787 0.337607
+TTAACG 58.983026 0.744256 0.839975 0.294632
+TTAACT 59.433245 1.308022 0.848313 0.29903
+TTAAGA 67.122161 0.843706 0.935688 0.3464
+TTAAGC 66.018228 0.798254 1.119481 0.453321
+TTAAGG 66.506716 0.710374 0.839902 0.294594
+TTAAGT 66.753794 0.905211 1.140738 0.466294
+TTAATA 63.819828 0.743822 1.103415 0.443597
+TTAATC 63.150419 0.892031 1.212023 0.510678
+TTAATG 63.621826 0.82171 1.185952 0.49429
+TTAATT 64.285082 0.846734 1.34982 0.600198
+TTACAA 65.46174 1.296755 1.044127 0.40833
+TTACAC 65.130337 0.94717 0.888321 0.320432
+TTACAG 65.018973 1.167293 1.03951 0.405624
+TTACAT 65.203937 1.198036 1.088248 0.434483
+TTACCA 61.458686 0.827279 0.811108 0.279575
+TTACCC 60.543519 0.738688 0.739633 0.243447
+TTACCG 61.181041 0.815409 0.790639 0.269059
+TTACCT 61.242453 0.79606 0.735824 0.241569
+TTACGA 65.085369 1.199075 1.003245 0.384584
+TTACGC 64.635893 0.934211 0.916011 0.33553
+TTACGG 64.326001 1.000719 0.970849 0.366107
+TTACGT 64.616639 1.143077 1.015937 0.391905
+TTACTA 63.266745 0.911959 0.827178 0.287925
+TTACTC 62.604602 0.937916 0.952472 0.355762
+TTACTG 62.797901 0.836127 0.89539 0.324264
+TTACTT 63.094468 1.013469 1.153735 0.474285
+TTAGAA 65.503824 0.956029 1.071249 0.424342
+TTAGAC 63.58052 1.11131 1.155969 0.475664
+TTAGAG 64.824432 0.920276 1.12312 0.455533
+TTAGAT 64.810881 0.855454 1.111674 0.448587
+TTAGCA 59.641736 0.729073 1.1093 0.447151
+TTAGCC 58.687394 0.793568 0.997702 0.381401
+TTAGCG 59.657817 0.887674 1.106853 0.445672
+TTAGCT 59.88938 0.855973 1.032361 0.401447
+TTAGGA 65.171484 0.749854 0.934045 0.345488
+TTAGGC 64.036594 0.848167 1.160503 0.478465
+TTAGGG 64.753149 0.717833 0.972543 0.367065
+TTAGGT 64.988101 0.779471 1.067338 0.42202
+TTAGTA 62.887163 0.755067 1.091994 0.436728
+TTAGTC 61.927919 0.96165 1.238744 0.527658
+TTAGTG 62.716395 0.788996 1.141075 0.4665
+TTAGTT 63.249727 0.979727 1.350659 0.600758
+TTATAA 59.49619 0.840342 0.872132 0.311712
+TTATAC 57.880717 0.683025 0.806386 0.277138
+TTATAG 59.122291 0.840099 0.863818 0.307266
+TTATAT 58.927544 0.675828 0.813125 0.280618
+TTATCA 53.936307 0.845532 1.024711 0.396993
+TTATCC 52.709666 0.847113 1.004508 0.385311
+TTATCG 53.893241 0.882025 1.033303 0.401996
+TTATCT 53.641608 0.804406 0.944118 0.351091
+TTATGA 58.440753 0.967793 0.951581 0.355263
+TTATGC 56.591905 1.024132 1.169302 0.483917
+TTATGG 57.849873 0.879004 0.885843 0.319092
+TTATGT 57.550091 0.80747 0.895926 0.324555
+TTATTA 54.608304 1.097261 1.120098 0.453696
+TTATTC 52.991999 1.431462 1.325157 0.583824
+TTATTG 54.224847 1.076599 1.052119 0.413026
+TTATTT 54.257213 1.192594 1.174267 0.487002
+TTCAAA 65.998935 0.770753 1.007563 0.38707
+TTCAAC 63.832242 0.868148 1.205597 0.506622
+TTCAAG 65.389676 0.783497 1.007929 0.387281
+TTCAAT 65.442645 0.787941 1.121373 0.454471
+TTCACA 62.439012 0.665437 0.976735 0.369442
+TTCACC 61.252264 0.725251 0.971551 0.366504
+TTCACG 62.147486 0.676426 0.987195 0.375392
+TTCACT 62.369294 0.690562 0.989743 0.376847
+TTCAGA 67.862068 0.950695 1.16407 0.480672
+TTCAGC 66.703702 1.118274 1.233164 0.524097
+TTCAGG 67.335248 0.862185 1.033738 0.40225
+TTCAGT 67.717296 1.015567 1.222612 0.517385
+TTCATA 65.716541 0.907655 1.105983 0.445147
+TTCATC 65.169013 0.901852 1.272349 0.549275
+TTCATG 65.46131 0.942636 1.174961 0.487434
+TTCATT 65.953033 0.963628 1.478981 0.688374
+TTCCAA 65.585855 1.318195 1.308277 0.572704
+TTCCAC 64.937298 1.079403 1.06799 0.422407
+TTCCAG 65.029437 1.492596 1.326798 0.584909
+TTCCAT 65.200283 1.326149 1.357508 0.605333
+TTCCCA 62.370579 1.139353 1.072229 0.424925
+TTCCCC 61.580662 0.982294 0.978417 0.370396
+TTCCCG 62.070648 1.164678 1.062215 0.418986
+TTCCCT 62.069336 1.165568 1.037212 0.40428
+TTCCGA 65.296258 1.573978 1.305958 0.571182
+TTCCGC 64.976789 1.340913 1.184772 0.493552
+TTCCGG 64.670092 1.431416 1.369031 0.613057
+TTCCGT 65.030975 1.596377 1.382376 0.622043
+TTCCTA 64.186508 1.126125 1.053382 0.413771
+TTCCTC 63.240509 1.173898 1.077961 0.428336
+TTCCTG 63.580318 1.091177 1.151725 0.473047
+TTCCTT 63.536907 1.259003 1.331172 0.587803
+TTCGAA 66.980563 1.064765 1.069874 0.423526
+TTCGAC 65.557026 0.721312 0.957192 0.358409
+TTCGAG 66.507578 0.971349 1.036378 0.403792
+TTCGAT 66.734345 1.02134 1.107314 0.44595
+TTCGCA 62.470388 0.776968 1.068304 0.422594
+TTCGCC 61.709204 0.69651 0.951475 0.355203
+TTCGCG 62.361165 0.7604 1.025382 0.397383
+TTCGCT 62.588348 0.757103 1.03507 0.403028
+TTCGGA 66.075274 0.971915 1.091343 0.436337
+TTCGGC 65.046878 1.198726 1.329326 0.586581
+TTCGGG 65.72806 0.980918 1.080261 0.429708
+TTCGGT 65.942678 1.110655 1.366515 0.611368
+TTCGTA 63.895042 0.875188 1.314353 0.576698
+TTCGTC 62.886577 0.951003 1.447536 0.666537
+TTCGTG 63.790504 0.92421 1.326376 0.584629
+TTCGTT 64.076193 1.009153 1.498559 0.702087
+TTCTAA 61.06799 0.825503 0.864882 0.307833
+TTCTAC 59.862608 0.66433 0.872722 0.312029
+TTCTAG 60.719993 0.804899 0.958608 0.359205
+TTCTAT 60.648455 0.712225 0.88229 0.317174
+TTCTCA 56.868881 0.655067 0.958303 0.359033
+TTCTCC 55.942524 0.652299 0.863546 0.307121
+TTCTCG 56.765913 0.753782 0.938744 0.348098
+TTCTCT 56.562544 0.679525 0.887229 0.319841
+TTCTGA 59.565888 0.833882 1.012226 0.38976
+TTCTGC 57.963316 0.929913 1.182514 0.492142
+TTCTGG 59.082857 0.787042 0.923484 0.339645
+TTCTGT 58.654343 0.890205 1.077794 0.428237
+TTCTTA 56.383088 0.970735 1.095748 0.438982
+TTCTTC 54.554777 1.224447 1.232552 0.523707
+TTCTTG 56.255758 0.938819 1.052238 0.413097
+TTCTTT 55.868365 1.035722 1.160208 0.478283
+TTGAAA 72.013102 1.921232 1.886963 0.992032
+TTGAAC 69.152094 1.793083 1.70405 0.851342
+TTGAAG 71.514437 2.052941 1.818848 0.938805
+TTGAAT 71.376713 1.938979 1.955149 1.046286
+TTGACA 60.886097 1.345461 1.010872 0.388978
+TTGACC 60.647293 1.154111 1.003233 0.384577
+TTGACG 60.706426 1.415543 1.000319 0.382903
+TTGACT 61.620942 1.484129 1.06866 0.422805
+TTGAGA 70.660866 1.931812 1.879126 0.985859
+TTGAGC 68.146556 1.993298 1.709569 0.855481
+TTGAGG 69.837851 1.92059 1.791308 0.917563
+TTGAGT 70.121008 2.1249 1.957919 1.048511
+TTGATA 65.177331 1.853877 1.560781 0.746266
+TTGATC 64.91079 1.762935 1.621455 0.790202
+TTGATG 64.969542 1.869443 1.626891 0.794179
+TTGATT 65.978102 2.197355 1.949818 1.04201
+TTGCAA 69.214073 2.197355 1.930097 1.026241
+TTGCAC 68.332943 1.993757 1.8471 0.960763
+TTGCAG 67.353989 2.197355 1.867192 0.976482
+TTGCAT 68.63123 2.197355 1.883099 0.988987
+TTGCCA 62.704492 2.197355 1.497043 0.701023
+TTGCCC 61.808211 2.197355 1.323574 0.582778
+TTGCCG 62.391915 2.197355 1.459292 0.674674
+TTGCCT 62.156544 2.197355 1.471595 0.683224
+TTGCGA 68.107389 2.197355 1.781191 0.909801
+TTGCGC 67.346157 2.197355 1.740169 0.878553
+TTGCGG 66.798933 2.197355 1.751525 0.887167
+TTGCGT 67.710234 2.197355 1.942598 1.036227
+TTGCTA 65.973978 1.880437 1.670732 0.826496
+TTGCTC 64.844148 2.197355 1.756984 0.891317
+TTGCTG 65.314494 2.080265 1.753638 0.888772
+TTGCTT 65.33987 2.197355 1.9686 1.057102
+TTGGAA 64.324372 1.784747 1.393721 0.629716
+TTGGAC 61.63306 1.047032 1.093341 0.437537
+TTGGAG 63.356945 1.331056 1.407756 0.639251
+TTGGAT 63.589971 1.336846 1.364172 0.609796
+TTGGCA 57.040093 0.925656 1.281489 0.555205
+TTGGCC 55.863294 0.744744 1.038574 0.405076
+TTGGCG 56.663558 0.877822 1.228467 0.521106
+TTGGCT 57.214172 0.963457 1.069924 0.423555
+TTGGGA 63.124296 1.385432 1.266766 0.545664
+TTGGGC 60.504821 1.057248 1.103074 0.443392
+TTGGGG 62.089323 1.241422 1.120478 0.453926
+TTGGGT 62.605928 1.234948 1.184591 0.493439
+TTGGTA 60.755446 1.03465 1.114123 0.45007
+TTGGTC 59.443247 0.955626 1.251114 0.535582
+TTGGTG 60.278516 1.064857 1.147447 0.470413
+TTGGTT 61.035347 1.115904 1.37237 0.615301
+TTGTAA 51.545279 0.974291 1.124318 0.456262
+TTGTAC 50.41116 0.769124 1.065844 0.421135
+TTGTAG 51.121753 1.031984 1.134287 0.462344
+TTGTAT 51.055814 0.665537 1.015878 0.391871
+TTGTCA 45.069525 1.168207 1.409624 0.640524
+TTGTCC 43.740182 1.04582 1.313451 0.576104
+TTGTCG 44.667465 1.148875 1.357793 0.605524
+TTGTCT 44.771967 1.166076 1.312604 0.575548
+TTGTGA 50.532067 0.922169 0.964617 0.362588
+TTGTGC 49.146867 0.766127 1.080655 0.429944
+TTGTGG 49.763966 0.915334 1.018645 0.393473
+TTGTGT 49.682343 0.70551 0.881466 0.31673
+TTGTTA 46.033689 0.731892 0.999306 0.382321
+TTGTTC 44.725032 0.836703 1.165054 0.481282
+TTGTTG 45.632519 0.73549 0.928552 0.342444
+TTGTTT 45.864301 0.847077 1.023276 0.396159
+TTTAAA 61.788453 2.029034 1.444772 0.664629
+TTTAAC 61.682492 1.151334 1.193981 0.499317
+TTTAAG 62.021814 1.988521 1.456115 0.672472
+TTTAAT 62.431805 1.776971 1.417294 0.645759
+TTTACA 57.474123 1.435591 1.180012 0.49058
+TTTACC 56.966879 1.355079 1.022971 0.395982
+TTTACG 57.37315 1.526943 1.135202 0.462903
+TTTACT 57.450457 1.508194 1.1155 0.450905
+TTTAGA 62.053095 2.005903 1.490447 0.696395
+TTTAGC 62.282389 1.220413 1.366862 0.6116
+TTTAGG 61.702354 1.71736 1.520106 0.717284
+TTTAGT 62.510832 2.154497 1.489514 0.695741
+TTTATA 59.551363 1.57631 1.118548 0.452754
+TTTATC 59.196719 1.253373 1.200591 0.50347
+TTTATG 59.860586 1.174663 1.219788 0.515594
+TTTATT 59.906022 1.390532 1.340173 0.593775
+TTTCAA 57.853794 2.197355 1.450088 0.668301
+TTTCAC 57.477715 2.15146 1.354199 0.603121
+TTTCAG 57.348714 2.197355 1.522447 0.718942
+TTTCAT 57.946746 2.197355 1.530289 0.724504
+TTTCCA 54.272234 2.18391 1.347862 0.598892
+TTTCCC 53.645209 2.005936 1.246999 0.532942
+TTTCCG 53.955171 2.196383 1.342416 0.595266
+TTTCCT 53.840779 2.197355 1.291007 0.561402
+TTTCGA 57.444452 2.197355 1.449679 0.668018
+TTTCGC 57.532435 2.197355 1.421786 0.648831
+TTTCGG 57.067147 2.197355 1.480522 0.68945
+TTTCGT 57.356398 2.197355 1.644597 0.807179
+TTTCTA 55.840889 2.02498 1.31605 0.577816
+TTTCTC 55.403707 2.1455 1.163745 0.480471
+TTTCTG 54.974804 2.187428 1.256082 0.538775
+TTTCTT 55.610472 2.197355 1.319118 0.579837
+TTTGAA 54.931345 1.435285 1.302952 0.569211
+TTTGAC 52.704697 0.821749 0.865736 0.30829
+TTTGAG 54.257885 1.165413 1.292299 0.562245
+TTTGAT 54.00036 1.131408 1.083396 0.43158
+TTTGCA 49.74045 0.864899 1.439238 0.660815
+TTTGCC 48.837777 0.710503 1.096196 0.439251
+TTTGCG 49.693596 0.83457 1.361406 0.607942
+TTTGCT 49.694634 0.806542 1.107478 0.44605
+TTTGGA 54.92902 1.359106 1.187646 0.495349
+TTTGGC 54.35795 1.025911 0.923924 0.339887
+TTTGGG 54.336591 1.254179 0.971479 0.366463
+TTTGGT 55.217854 1.226108 1.112563 0.449125
+TTTGTA 52.984563 0.877875 0.857739 0.304028
+TTTGTC 52.071705 0.866979 0.951898 0.35544
+TTTGTG 52.799814 0.841957 0.805343 0.2766
+TTTGTT 52.930004 1.04374 1.014281 0.390947
+TTTTAA 49.398873 1.061065 1.023039 0.396022
+TTTTAC 48.636771 0.751509 0.880728 0.316332
+TTTTAG 48.957138 0.952179 1.08753 0.434053
+TTTTAT 48.952378 0.820669 0.849165 0.299481
+TTTTCA 43.986539 0.633818 1.109826 0.447469
+TTTTCC 43.090089 0.606613 0.988212 0.375972
+TTTTCG 43.807129 0.616788 1.044928 0.408799
+TTTTCT 43.65927 0.562496 0.904613 0.329287
+TTTTGA 48.647402 1.036147 0.864714 0.307744
+TTTTGC 47.99026 0.613566 0.819302 0.283823
+TTTTGG 48.135761 0.916502 0.806712 0.277305
+TTTTGT 48.062561 0.739762 0.711499 0.22969
+TTTTTA 46.922068 1.507824 0.825201 0.286893
+TTTTTC 43.649719 0.581956 0.760674 0.253909
+TTTTTG 46.371438 1.40407 0.692663 0.22063
+TTTTTT 44.418696 0.617514 0.622786 0.1881
diff --git a/src/builtin_models/r73.t.006.ont.model b/src/builtin_models/r73.t.006.ont.model
new file mode 100644
index 0000000..ae7c576
--- /dev/null
+++ b/src/builtin_models/r73.t.006.ont.model
@@ -0,0 +1,4096 @@
+AAAAAA 62.784241 0.841324 0.664989 0.206892
+AAAAAC 58.017544 0.664955 0.70427 0.225492
+AAAAAG 62.984396 0.796764 0.689218 0.218302
+AAAAAT 61.414159 0.813223 0.827014 0.286941
+AAAACA 56.506612 0.697534 0.713271 0.229829
+AAAACC 54.061509 0.739083 0.863163 0.305958
+AAAACG 56.188559 0.709643 0.704141 0.22543
+AAAACT 55.683943 0.650893 0.658659 0.203945
+AAAAGA 62.865976 0.929638 0.717759 0.232002
+AAAAGC 58.477597 0.670697 0.789817 0.267801
+AAAAGG 61.923811 0.757937 0.699195 0.223059
+AAAAGT 60.811465 0.825215 0.971694 0.365441
+AAAATA 56.306283 0.654193 0.714383 0.230367
+AAAATC 52.627998 0.844501 0.894963 0.323021
+AAAATG 55.654064 0.771559 0.785479 0.265598
+AAAATT 53.913967 0.95383 0.937723 0.346445
+AAACAA 63.422226 1.135149 0.88164 0.315834
+AAACAC 60.668299 0.76554 0.685284 0.216435
+AAACAG 63.565959 1.515607 0.942509 0.349101
+AAACAT 63.197471 1.111051 0.919619 0.336461
+AAACCA 59.071459 1.314261 0.83544 0.291337
+AAACCC 56.951027 0.970066 0.756431 0.251002
+AAACCG 58.842517 1.228132 0.811708 0.279011
+AAACCT 58.20064 1.084118 0.767309 0.256435
+AAACGA 62.435156 1.265622 0.873574 0.31151
+AAACGC 59.748539 0.853789 0.77309 0.259339
+AAACGG 61.490944 1.276305 0.919693 0.336501
+AAACGT 60.744115 1.007931 1.047506 0.409032
+AAACTA 58.293278 0.79015 0.658813 0.204017
+AAACTC 55.671458 0.546149 0.633932 0.192569
+AAACTG 57.34504 0.680055 0.672798 0.210547
+AAACTT 55.90898 0.627683 0.812055 0.279191
+AAAGAA 67.659057 1.372131 0.974545 0.36705
+AAAGAC 60.944993 0.742285 0.681641 0.214712
+AAAGAG 66.909955 1.589687 0.986571 0.373865
+AAAGAT 64.847203 1.016182 0.904117 0.327989
+AAAGCA 61.890245 1.420362 0.863678 0.306232
+AAAGCC 58.224525 1.034601 0.751422 0.248513
+AAAGCG 61.335831 1.266508 0.848065 0.297966
+AAAGCT 60.992219 1.374263 0.86741 0.308219
+AAAGGA 63.288027 1.012301 0.83107 0.289054
+AAAGGC 58.520307 0.717313 0.903737 0.327783
+AAAGGG 62.394431 0.896685 0.718107 0.23217
+AAAGGT 61.943467 0.82477 0.851918 0.299998
+AAAGTA 54.393707 0.905274 0.903068 0.327419
+AAAGTC 48.623653 0.875229 1.103561 0.4423
+AAAGTG 53.678084 1.140211 0.907728 0.329956
+AAAGTT 50.531213 1.017397 1.0537 0.412665
+AAATAA 58.616654 1.002354 0.715753 0.231029
+AAATAC 54.760694 0.596102 0.672466 0.210391
+AAATAG 58.316964 0.963072 0.75254 0.249067
+AAATAT 57.280882 1.061829 0.739829 0.242784
+AAATCA 52.916185 1.109276 0.840536 0.294007
+AAATCC 50.488839 0.718756 0.850642 0.299325
+AAATCG 52.791064 1.101452 0.846597 0.297192
+AAATCT 51.857367 0.71101 0.764885 0.255221
+AAATGA 53.466971 0.745535 0.914685 0.333757
+AAATGC 49.732924 0.878593 1.114338 0.448795
+AAATGG 53.495672 0.64861 0.693799 0.220482
+AAATGT 52.368578 0.583674 0.748446 0.247038
+AAATTA 48.986728 0.795485 1.022526 0.394488
+AAATTC 44.806577 0.913397 1.187996 0.494021
+AAATTG 48.316073 0.689136 0.867132 0.308071
+AAATTT 45.629387 0.677375 1.003985 0.383807
+AACAAA 64.426022 0.904895 0.839858 0.293651
+AACAAC 59.851502 0.762508 0.803356 0.274717
+AACAAG 65.342015 0.709916 0.836838 0.292068
+AACAAT 63.838488 0.777662 0.992079 0.377001
+AACACA 62.992226 0.686212 0.708427 0.227492
+AACACC 60.487463 0.628258 0.64547 0.19785
+AACACG 62.598564 0.763976 0.720639 0.233399
+AACACT 62.195556 0.652057 0.729 0.237473
+AACAGA 65.699457 0.912753 0.816471 0.281471
+AACAGC 62.065673 1.316239 0.811281 0.278791
+AACAGG 65.586032 0.727664 0.858356 0.303406
+AACAGT 64.716207 0.808093 1.282947 0.554416
+AACATA 61.916372 0.887527 0.736233 0.241016
+AACATC 58.230419 0.985388 0.883505 0.316837
+AACATG 61.289946 1.041119 0.883952 0.317078
+AACATT 59.623391 1.187249 1.119656 0.452011
+AACCAA 66.334482 0.974103 0.911136 0.331816
+AACCAC 63.670096 0.637538 0.673002 0.210643
+AACCAG 67.422378 0.967102 1.034039 0.40117
+AACCAT 66.43649 0.980337 1.005509 0.384681
+AACCCA 63.843258 1.217847 0.9589 0.358247
+AACCCC 61.829552 0.83389 0.79022 0.268006
+AACCCG 63.655121 1.231476 0.941881 0.348752
+AACCCT 63.408978 1.030398 0.915638 0.334278
+AACCGA 66.460534 1.105348 0.954593 0.355836
+AACCGC 63.530452 0.658885 0.676134 0.212115
+AACCGG 65.858927 1.006494 1.016725 0.391136
+AACCGT 64.674799 1.084162 1.338156 0.590586
+AACCTA 62.299878 0.629492 0.670779 0.2096
+AACCTC 59.460364 0.7598 0.683597 0.215637
+AACCTG 61.313204 0.757845 0.870743 0.309997
+AACCTT 59.754862 0.86217 1.08427 0.430753
+AACGAA 69.075847 1.366569 1.075664 0.425635
+AACGAC 63.194137 0.700558 0.736106 0.240954
+AACGAG 68.560095 1.106009 1.036918 0.402846
+AACGAT 66.378545 1.036409 1.070791 0.422746
+AACGCA 65.49891 1.36092 0.891319 0.32105
+AACGCC 62.407942 0.886891 0.676746 0.212403
+AACGCG 64.97333 1.477736 0.883339 0.316748
+AACGCT 64.560014 1.182928 0.925959 0.339946
+AACGGA 63.657209 0.981464 0.803188 0.27463
+AACGGC 58.183941 0.879614 0.916114 0.334539
+AACGGG 62.971604 0.813757 0.892606 0.321746
+AACGGT 62.079324 0.923443 1.154445 0.473241
+AACGTA 53.302196 1.193642 1.031701 0.39981
+AACGTC 47.148536 1.517953 1.284159 0.555201
+AACGTG 52.305214 1.321028 1.082214 0.429529
+AACGTT 49.436379 1.52312 1.244957 0.529973
+AACTAA 62.750012 0.864833 0.765101 0.255329
+AACTAC 58.859351 0.572898 0.590022 0.172912
+AACTAG 62.642001 0.803297 0.797156 0.271543
+AACTAT 61.025568 0.695277 0.718361 0.232293
+AACTCA 58.514452 0.92 0.669999 0.209235
+AACTCC 56.012814 0.771689 0.649 0.199475
+AACTCG 58.472214 0.942653 0.661275 0.205161
+AACTCT 57.31516 0.774143 0.643561 0.196973
+AACTGA 55.338103 1.140479 0.763805 0.254681
+AACTGC 50.525479 0.812492 0.940734 0.348115
+AACTGG 55.795777 0.633561 0.666632 0.207659
+AACTGT 54.090945 0.696286 0.776107 0.260859
+AACTTA 50.482873 0.787434 0.838811 0.293102
+AACTTC 45.199573 0.840618 1.039091 0.404113
+AACTTG 49.737077 0.654659 0.753482 0.249535
+AACTTT 46.466996 0.868944 0.91803 0.335589
+AAGAAA 70.365122 1.091708 1.17504 0.485961
+AAGAAC 64.978639 1.102884 1.01607 0.390758
+AAGAAG 70.829315 1.072892 1.18506 0.492191
+AAGAAT 69.064328 1.024982 1.410571 0.639168
+AAGACA 61.508755 1.414082 0.678446 0.213204
+AAGACC 57.894553 1.268191 0.710663 0.228569
+AAGACG 60.241136 0.900009 0.679198 0.213558
+AAGACT 59.422014 0.762357 0.712454 0.229434
+AAGAGA 69.109227 1.050808 1.043869 0.406904
+AAGAGC 63.016916 1.245769 0.916856 0.334946
+AAGAGG 68.070751 1.008806 1.095307 0.437347
+AAGAGT 66.529383 1.091958 1.404479 0.635032
+AAGATA 59.437843 0.847723 0.856771 0.302566
+AAGATC 54.974748 1.114417 1.088694 0.433393
+AAGATG 58.803283 0.964314 0.965193 0.361779
+AAGATT 56.903216 1.160763 1.148823 0.469788
+AAGCAA 68.32369 0.924932 0.936334 0.345676
+AAGCAC 65.463948 0.786119 0.847928 0.297894
+AAGCAG 68.680597 0.952949 0.969721 0.364328
+AAGCAT 67.789493 0.944333 1.025453 0.396183
+AAGCCA 63.141317 0.904848 0.755507 0.250542
+AAGCCC 61.002835 0.726585 0.662994 0.205962
+AAGCCG 62.76813 0.945122 0.751385 0.248494
+AAGCCT 62.489657 0.755088 0.74641 0.24603
+AAGCGA 67.852526 1.039098 0.856903 0.302636
+AAGCGC 64.20442 0.768408 0.795931 0.270917
+AAGCGG 66.536799 0.923593 0.932707 0.343669
+AAGCGT 65.144882 0.873829 1.260856 0.540158
+AAGCTA 62.41532 0.689683 0.736473 0.241134
+AAGCTC 59.331353 0.812282 0.791423 0.268618
+AAGCTG 61.507658 0.821548 0.968801 0.36381
+AAGCTT 60.294043 0.949788 1.147311 0.468861
+AAGGAA 72.311896 1.835467 1.343446 0.594091
+AAGGAC 64.429418 0.871845 0.851306 0.299675
+AAGGAG 71.322523 1.777551 1.286361 0.55663
+AAGGAT 68.897363 1.275874 1.262325 0.541102
+AAGGCA 65.34884 1.560531 1.026348 0.396702
+AAGGCC 61.652799 1.04704 0.799081 0.272526
+AAGGCG 64.831311 1.542931 1.001067 0.382136
+AAGGCT 64.47702 1.628069 1.034457 0.401413
+AAGGGA 66.143924 1.15301 1.015832 0.390621
+AAGGGC 59.435878 0.750996 0.996377 0.379453
+AAGGGG 64.971963 0.906592 0.918714 0.335964
+AAGGGT 64.481649 0.870855 1.025773 0.396369
+AAGGTA 57.012275 0.796808 0.914566 0.333692
+AAGGTC 50.907256 0.978218 1.091803 0.43525
+AAGGTG 56.426214 0.83201 0.963827 0.361012
+AAGGTT 53.136574 1.092376 1.155472 0.473873
+AAGTAA 57.953203 0.991451 0.816195 0.281328
+AAGTAC 53.613814 0.622358 0.811053 0.278674
+AAGTAG 57.256059 1.067769 0.842401 0.294986
+AAGTAT 56.213455 1.193969 0.797344 0.271638
+AAGTCA 50.819557 0.97755 0.980942 0.37067
+AAGTCC 48.276643 0.792077 0.946625 0.35139
+AAGTCG 50.477086 1.088407 0.933462 0.344087
+AAGTCT 49.735043 0.907135 0.881037 0.315511
+AAGTGA 53.306592 0.678263 0.886526 0.318463
+AAGTGC 49.433957 0.6755 1.024387 0.395565
+AAGTGG 52.828973 0.749851 0.810914 0.278602
+AAGTGT 52.038183 0.674416 0.780243 0.262946
+AAGTTA 48.007408 0.630943 0.912782 0.332716
+AAGTTC 44.290059 0.77594 1.008773 0.386556
+AAGTTG 47.333725 0.602457 0.800542 0.273274
+AAGTTT 45.285089 0.73679 0.890921 0.320835
+AATAAA 63.636505 0.840322 0.748502 0.247065
+AATAAC 59.685905 0.656607 0.690755 0.219032
+AATAAG 64.52021 0.857184 0.825134 0.285963
+AATAAT 62.983344 0.793739 0.870756 0.310004
+AATACA 60.36729 1.073242 0.82824 0.287579
+AATACC 57.890403 0.746418 0.674456 0.211326
+AATACG 59.937428 1.060824 0.799302 0.272639
+AATACT 59.655148 0.998827 0.751309 0.248456
+AATAGA 63.383558 0.826356 0.76673 0.256145
+AATAGC 59.837091 0.699229 0.751366 0.248485
+AATAGG 63.055476 0.781815 0.758275 0.25192
+AATAGT 62.125679 0.867478 1.004546 0.384129
+AATATA 58.75 0.600987 0.626693 0.18928
+AATATC 55.176978 0.884412 0.703778 0.225256
+AATATG 58.212445 0.611393 0.739852 0.242795
+AATATT 56.614556 0.900506 0.923716 0.338712
+AATCAA 62.513532 1.130908 1.015373 0.390356
+AATCAC 60.180654 0.832095 0.781393 0.263528
+AATCAG 63.060073 1.359994 1.152035 0.47176
+AATCAT 62.720318 1.060339 1.081037 0.428828
+AATCCA 58.91555 1.462466 1.0317 0.399809
+AATCCC 57.082136 1.14308 0.930557 0.342481
+AATCCG 58.73842 1.389806 1.017538 0.391606
+AATCCT 58.121756 1.437644 0.962775 0.360421
+AATCGA 62.207657 1.291043 1.088029 0.432995
+AATCGC 59.64124 0.853618 0.830008 0.2885
+AATCGG 61.512618 1.291374 1.108108 0.445037
+AATCGT 60.615294 1.258057 1.243952 0.529332
+AATCTA 57.825829 1.058197 0.803909 0.275
+AATCTC 55.570502 0.579973 0.612186 0.182746
+AATCTG 57.10375 0.841707 0.821697 0.284178
+AATCTT 55.653043 0.732857 0.937546 0.346347
+AATGAA 62.657844 1.754217 1.113846 0.448498
+AATGAC 56.290951 1.224941 0.773038 0.259313
+AATGAG 61.30409 1.620618 1.071159 0.422964
+AATGAT 60.169442 1.556487 1.122861 0.453954
+AATGCA 58.312428 2.16247 1.100384 0.440391
+AATGCC 55.194328 1.455733 0.986596 0.37388
+AATGCG 57.775052 1.605663 1.092967 0.435947
+AATGCT 57.085014 1.657865 1.087291 0.432555
+AATGGA 59.241272 1.193379 0.986878 0.37404
+AATGGC 55.038431 0.669624 0.865201 0.307042
+AATGGG 58.284183 0.987147 0.848551 0.298222
+AATGGT 57.819859 0.930288 0.957724 0.357588
+AATGTA 51.773317 0.903194 0.769385 0.257477
+AATGTC 46.061904 0.826792 0.884792 0.31753
+AATGTG 50.629512 0.715955 0.755346 0.250462
+AATGTT 48.011975 0.901186 0.848175 0.298024
+AATTAA 56.494059 1.503767 0.926972 0.340504
+AATTAC 52.968069 0.954051 0.793436 0.269644
+AATTAG 56.037995 1.441737 0.895941 0.32355
+AATTAT 55.006142 1.440715 0.848883 0.298397
+AATTCA 50.495043 1.444907 1.049297 0.410082
+AATTCC 48.176769 1.003051 0.960068 0.358902
+AATTCG 50.336401 1.418523 1.023845 0.395252
+AATTCT 49.538934 1.098315 0.879712 0.314799
+AATTGA 51.500569 0.825394 0.925987 0.339962
+AATTGC 48.167534 0.630581 0.929165 0.341713
+AATTGG 51.555015 0.783402 0.760232 0.252896
+AATTGT 50.787518 0.691199 0.733219 0.239537
+AATTTA 46.909867 0.67134 0.898253 0.324803
+AATTTC 43.191635 0.603322 0.841879 0.294711
+AATTTG 46.317867 0.629152 0.743678 0.244681
+AATTTT 44.071847 0.494687 0.608003 0.180876
+ACAAAA 63.213519 0.856033 0.756132 0.250853
+ACAAAC 58.209383 0.776196 0.844021 0.295837
+ACAAAG 63.191651 0.651001 0.770709 0.258142
+ACAAAT 61.530767 0.756481 0.971616 0.365396
+ACAACA 57.712419 0.630341 0.761559 0.253558
+ACAACC 55.253461 0.652913 0.830217 0.288609
+ACAACG 57.375401 0.596014 0.762077 0.253817
+ACAACT 56.874131 0.559289 0.72883 0.23739
+ACAAGA 63.914543 0.795807 0.748034 0.246834
+ACAAGC 59.402144 0.766629 0.840101 0.293778
+ACAAGG 63.151595 0.676794 0.770482 0.258028
+ACAAGT 61.913259 0.901995 1.165274 0.479915
+ACAATA 57.683371 0.765887 0.79285 0.269345
+ACAATC 54.14879 1.056896 1.020429 0.393275
+ACAATG 57.095468 0.930785 0.881977 0.316015
+ACAATT 55.700504 1.204962 1.059247 0.415928
+ACACAA 66.34182 0.705312 0.769239 0.257404
+ACACAC 63.627229 0.661386 0.698237 0.222601
+ACACAG 66.84982 0.789512 0.81315 0.279755
+ACACAT 66.015805 0.71429 0.838092 0.292725
+ACACCA 62.556668 0.757708 0.668902 0.208721
+ACACCC 60.518615 0.742386 0.655263 0.20237
+ACACCG 62.219454 0.740727 0.662824 0.205883
+ACACCT 62.013617 0.744156 0.707445 0.227019
+ACACGA 65.848535 0.758609 0.720437 0.233301
+ACACGC 62.982986 0.950451 0.699734 0.223317
+ACACGG 65.002352 0.776348 0.812171 0.27925
+ACACGT 63.899865 0.685329 1.163315 0.478706
+ACACTA 61.445713 0.760152 0.616091 0.184497
+ACACTC 58.127614 0.690858 0.679903 0.213891
+ACACTG 60.362125 0.716741 0.80401 0.275052
+ACACTT 58.793964 0.808199 1.016361 0.390926
+ACAGAA 66.830939 1.264349 0.809969 0.278116
+ACAGAC 59.875278 0.673715 0.770103 0.257837
+ACAGAG 65.59372 1.122215 0.828963 0.287956
+ACAGAT 63.51297 0.812664 0.87671 0.313189
+ACAGCA 61.072149 0.938724 0.797867 0.271906
+ACAGCC 58.178718 0.637828 0.734674 0.240251
+ACAGCG 60.650006 0.866822 0.778572 0.262102
+ACAGCT 60.482285 0.919852 0.780726 0.26319
+ACAGGA 63.370229 0.806303 0.855856 0.302081
+ACAGGC 57.762847 0.819086 0.990429 0.376061
+ACAGGG 62.390623 0.685598 0.746687 0.246167
+ACAGGT 61.361663 0.755364 0.946016 0.351051
+ACAGTA 54.158254 1.002772 1.034571 0.401479
+ACAGTC 48.663033 1.215951 1.277217 0.550706
+ACAGTG 53.461774 1.110986 1.098564 0.4393
+ACAGTT 50.437446 1.472518 1.342768 0.593641
+ACATAA 60.5032 0.65021 0.625266 0.188634
+ACATAC 56.615817 0.677411 0.734003 0.239921
+ACATAG 60.382369 0.757532 0.64898 0.199466
+ACATAT 58.747895 0.530596 0.699093 0.22301
+ACATCA 55.105341 0.656993 0.787553 0.26665
+ACATCC 52.920649 0.75807 0.886313 0.318349
+ACATCG 54.979597 0.650453 0.744435 0.245055
+ACATCT 54.071767 0.543093 0.704322 0.225517
+ACATGA 55.037583 0.902097 0.962456 0.360241
+ACATGC 50.129484 0.836005 1.231682 0.521519
+ACATGG 54.934854 0.709945 0.851467 0.29976
+ACATGT 53.112837 0.68073 1.040525 0.40495
+ACATTA 49.78652 0.814628 1.133914 0.460673
+ACATTC 45.198768 0.863893 1.375896 0.615745
+ACATTG 49.13493 0.755356 1.097253 0.438513
+ACATTT 46.366751 1.005483 1.349396 0.598042
+ACCAAA 64.313062 1.048469 0.846351 0.297063
+ACCAAC 59.670252 0.883186 0.911974 0.332274
+ACCAAG 65.265747 0.76156 0.84742 0.297626
+ACCAAT 63.615297 0.882491 1.07074 0.422716
+ACCACA 63.379085 0.661618 0.687036 0.217266
+ACCACC 60.79615 0.534178 0.684018 0.215836
+ACCACG 63.006763 0.692378 0.699676 0.223289
+ACCACT 62.523134 0.539626 0.736304 0.241051
+ACCAGA 66.368734 1.197772 0.847217 0.297519
+ACCAGC 62.078191 0.956546 0.862555 0.305635
+ACCAGG 66.115057 0.909843 0.916374 0.334682
+ACCAGT 65.21807 0.959562 1.344549 0.594823
+ACCATA 62.529918 0.897333 0.777586 0.261604
+ACCATC 58.863034 1.044369 0.939046 0.347178
+ACCATG 61.971745 0.963527 0.97267 0.365991
+ACCATT 60.271288 1.2167 1.140035 0.464408
+ACCCAA 67.653859 0.801154 0.86418 0.306499
+ACCCAC 64.941617 0.700307 0.752641 0.249118
+ACCCAG 68.784059 0.771385 0.843102 0.295354
+ACCCAT 67.816736 0.748602 0.894881 0.322976
+ACCCCA 65.898966 0.783292 0.717518 0.231885
+ACCCCC 63.781435 0.595663 0.606443 0.18018
+ACCCCG 65.769422 0.873202 0.740749 0.243237
+ACCCCT 65.280979 0.721341 0.708793 0.227668
+ACCCGA 68.347383 0.75395 0.798547 0.272254
+ACCCGC 64.864317 0.811887 0.728935 0.237441
+ACCCGG 67.613875 0.723945 0.83323 0.290182
+ACCCGT 66.269129 0.8451 1.350364 0.598686
+ACCCTA 64.077458 0.894032 0.699058 0.222993
+ACCCTC 60.747118 0.78436 0.689732 0.218546
+ACCCTG 63.132441 0.86275 0.896549 0.32388
+ACCCTT 61.450547 1.496644 1.08211 0.429467
+ACCGAA 69.202749 0.903299 0.826858 0.286859
+ACCGAC 63.209999 0.732644 0.729163 0.237552
+ACCGAG 68.625124 0.865576 0.80996 0.278111
+ACCGAT 66.735958 0.878417 1.01293 0.388948
+ACCGCA 65.549269 0.955645 0.708726 0.227636
+ACCGCC 62.675717 0.620625 0.589125 0.172518
+ACCGCG 65.344954 0.951242 0.731085 0.238492
+ACCGCT 64.728657 0.763704 0.740355 0.243043
+ACCGGA 64.238102 1.238674 0.844192 0.295927
+ACCGGC 58.077807 1.113045 1.031233 0.399538
+ACCGGG 63.347786 1.012476 0.892928 0.321919
+ACCGGT 62.149593 1.04198 1.145098 0.467505
+ACCGTA 53.36576 1.478415 1.203469 0.503704
+ACCGTC 47.315141 1.597733 1.4642 0.675964
+ACCGTG 52.310549 1.467415 1.255846 0.536942
+ACCGTT 49.47108 1.696569 1.41529 0.642378
+ACCTAA 63.776655 0.703814 0.61634 0.184609
+ACCTAC 59.578746 0.523272 0.599181 0.176954
+ACCTAG 63.725531 0.626292 0.664023 0.206441
+ACCTAT 61.742409 0.60162 0.65958 0.204373
+ACCTCA 59.414651 0.669841 0.630453 0.190986
+ACCTCC 57.031333 0.52731 0.636075 0.193546
+ACCTCG 59.316305 0.708902 0.620333 0.186406
+ACCTCT 58.395676 0.56722 0.662944 0.205939
+ACCTGA 55.635113 1.053768 0.863254 0.306006
+ACCTGC 50.575882 0.882512 1.131147 0.458988
+ACCTGG 56.104725 0.649298 0.756013 0.250793
+ACCTGT 54.288413 0.86683 0.979928 0.370096
+ACCTTA 50.748659 0.869426 1.045624 0.40793
+ACCTTC 45.270501 0.943442 1.270523 0.546382
+ACCTTG 49.838155 0.739536 0.941853 0.348736
+ACCTTT 46.687408 1.009307 1.171231 0.4836
+ACGAAA 69.38356 1.024933 1.079895 0.428149
+ACGAAC 63.363213 1.04743 1.007002 0.385539
+ACGAAG 69.593364 0.873299 1.100542 0.440487
+ACGAAT 67.63756 1.221551 1.290652 0.559418
+ACGACA 60.880981 0.628378 0.649974 0.199925
+ACGACC 57.613962 0.507011 0.698384 0.222671
+ACGACG 60.497573 0.640778 0.665339 0.207056
+ACGACT 59.686449 0.58315 0.752355 0.248976
+ACGAGA 67.544836 1.552371 0.950451 0.353523
+ACGAGC 61.406936 1.001468 0.967433 0.36304
+ACGAGG 66.50632 1.123903 0.992728 0.37737
+ACGAGT 64.699725 1.240371 1.244541 0.529708
+ACGATA 58.743435 0.909434 0.887833 0.319168
+ACGATC 54.316208 1.295662 1.196031 0.499041
+ACGATG 58.105787 1.069042 1.019497 0.392737
+ACGATT 56.133699 1.270279 1.197687 0.500078
+ACGCAA 69.384827 0.897775 0.975043 0.367331
+ACGCAC 66.238269 0.89984 0.949153 0.352799
+ACGCAG 69.856249 0.852985 0.9401 0.347763
+ACGCAT 68.821719 0.907627 1.131077 0.458945
+ACGCCA 65.191663 0.714387 0.642935 0.196686
+ACGCCC 63.004228 0.7275 0.637587 0.194237
+ACGCCG 65.093186 0.659394 0.663743 0.206311
+ACGCCT 64.519864 0.652862 0.765771 0.255665
+ACGCGA 69.18165 0.823655 0.856496 0.30242
+ACGCGC 65.015205 0.868438 0.887816 0.319159
+ACGCGG 67.878524 0.790111 0.987433 0.374355
+ACGCGT 66.341962 0.787266 1.400307 0.632204
+ACGCTA 63.561877 1.0381 0.817013 0.281752
+ACGCTC 59.886374 0.990012 0.84885 0.29838
+ACGCTG 62.465061 1.103401 0.951699 0.354219
+ACGCTT 60.900813 1.347003 1.188887 0.494577
+ACGGAA 66.930829 1.411617 0.998948 0.380923
+ACGGAC 58.92143 0.660985 0.812959 0.279657
+ACGGAG 65.651621 1.285173 0.988091 0.37473
+ACGGAT 63.835424 1.077035 0.954977 0.356051
+ACGGCA 61.270282 1.504483 0.984795 0.372856
+ACGGCC 57.278948 0.900709 0.888879 0.319733
+ACGGCG 60.651922 1.316467 0.969481 0.364193
+ACGGCT 60.511152 1.608393 0.938776 0.347029
+ACGGGA 60.530116 0.996556 1.039803 0.404529
+ACGGGC 53.857487 0.971397 1.33014 0.585287
+ACGGGG 59.789646 0.869764 0.934567 0.344698
+ACGGGT 59.148434 0.800586 0.965317 0.361849
+ACGGTA 52.117505 0.894221 1.143356 0.466439
+ACGGTC 46.271083 0.916105 1.442023 0.660664
+ACGGTG 51.42829 0.758003 1.154199 0.47309
+ACGGTT 48.16533 1.068373 1.377015 0.616496
+ACGTAA 54.181497 1.116475 0.926884 0.340456
+ACGTAC 50.065169 0.636158 0.920834 0.337128
+ACGTAG 53.774427 1.237667 1.002729 0.383087
+ACGTAT 52.259051 0.802179 0.881456 0.315736
+ACGTCA 46.835313 1.002158 1.127081 0.456515
+ACGTCC 44.571596 0.798384 1.075352 0.42545
+ACGTCG 46.606441 1.040734 1.112732 0.447825
+ACGTCT 45.857131 0.864331 0.976351 0.368071
+ACGTGA 49.54229 0.719965 1.086138 0.431867
+ACGTGC 45.735122 0.793244 1.157199 0.474935
+ACGTGG 49.084554 0.75188 0.936948 0.346016
+ACGTGT 48.054687 0.599172 0.82344 0.285083
+ACGTTA 44.680621 0.729459 1.097451 0.438632
+ACGTTC 41.164438 0.795584 1.150313 0.470703
+ACGTTG 44.064942 0.676603 0.934784 0.344818
+ACGTTT 42.114503 0.64617 0.947756 0.35202
+ACTAAA 65.28789 0.73913 0.712169 0.229296
+ACTAAC 60.807661 0.794909 0.7141 0.230229
+ACTAAG 66.063383 0.663576 0.752278 0.248937
+ACTAAT 64.490836 0.719893 0.930026 0.342189
+ACTACA 61.945128 0.756335 0.64047 0.195556
+ACTACC 59.467917 0.641323 0.594296 0.174794
+ACTACG 61.706847 0.792534 0.648753 0.199362
+ACTACT 61.175247 0.671606 0.629427 0.19052
+ACTAGA 65.049676 0.640388 0.713038 0.229716
+ACTAGC 60.923862 1.104768 0.764669 0.255113
+ACTAGG 64.956238 0.649887 0.799795 0.272892
+ACTAGT 63.804585 0.621582 1.159129 0.476124
+ACTATA 59.987302 0.869469 0.669012 0.208772
+ACTATC 56.258522 0.866986 0.774999 0.2603
+ACTATG 59.352951 0.800545 0.755685 0.25063
+ACTATT 57.658411 0.891986 0.955076 0.356106
+ACTCAA 64.758562 0.78653 0.841767 0.294653
+ACTCAC 62.241123 0.585312 0.637505 0.194199
+ACTCAG 65.618193 0.918053 0.951711 0.354226
+ACTCAT 64.688692 0.892808 0.911859 0.332211
+ACTCCA 61.72702 1.079236 0.821128 0.283883
+ACTCCC 59.616908 0.693799 0.700877 0.223864
+ACTCCG 61.429014 0.990932 0.856854 0.30261
+ACTCCT 61.028097 1.03676 0.818876 0.282715
+ACTCGA 64.790634 0.944302 0.803085 0.274578
+ACTCGC 61.802921 0.623996 0.635915 0.193473
+ACTCGG 64.118038 0.995327 0.901943 0.326807
+ACTCGT 62.853222 0.831524 1.095473 0.437446
+ACTCTA 60.260232 0.607242 0.601855 0.17814
+ACTCTC 57.563477 0.953235 0.629839 0.190707
+ACTCTG 59.426331 0.600221 0.779984 0.262816
+ACTCTT 58.013823 0.678149 1.021984 0.394175
+ACTGAA 61.447293 1.462496 0.947009 0.351604
+ACTGAC 54.463868 0.871943 0.755909 0.250742
+ACTGAG 59.222783 1.291859 0.847618 0.29773
+ACTGAT 58.734732 1.404165 0.963577 0.360871
+ACTGCA 56.305732 1.646081 1.100664 0.44056
+ACTGCC 53.399609 1.222433 0.94146 0.348518
+ACTGCG 55.766436 1.550779 1.082998 0.429995
+ACTGCT 55.521581 1.393382 0.993163 0.377618
+ACTGGA 58.884358 0.992349 0.869813 0.309501
+ACTGGC 54.356329 0.591018 0.806277 0.276216
+ACTGGG 57.876222 0.734623 0.726302 0.236156
+ACTGGT 57.395238 0.717059 0.807575 0.276883
+ACTGTA 51.019427 0.691179 0.795967 0.270935
+ACTGTC 45.955606 0.888113 1.012191 0.388522
+ACTGTG 50.15253 0.707293 0.817663 0.282088
+ACTGTT 47.639581 1.006849 0.910469 0.331452
+ACTTAA 55.80541 1.076019 0.851871 0.299974
+ACTTAC 52.364088 0.835585 0.751086 0.248346
+ACTTAG 55.739518 1.113365 0.794369 0.27012
+ACTTAT 54.325739 0.972171 0.779645 0.262644
+ACTTCA 49.348051 1.179136 1.02942 0.398485
+ACTTCC 47.141804 0.99705 0.981791 0.371151
+ACTTCG 49.188173 1.141995 1.002303 0.382844
+ACTTCT 48.449673 1.144907 0.921316 0.337392
+ACTTGA 51.271256 0.853139 0.93936 0.347353
+ACTTGC 47.601486 0.560085 0.856986 0.30268
+ACTTGG 51.19913 0.846508 0.730205 0.238062
+ACTTGT 50.251081 0.846354 0.744772 0.245221
+ACTTTA 46.085306 0.567223 0.832727 0.289919
+ACTTTC 42.707016 0.689019 0.881679 0.315855
+ACTTTG 45.568917 0.553403 0.703075 0.224919
+ACTTTT 43.649144 0.508674 0.656642 0.203009
+AGAAAA 64.498969 0.825046 0.827513 0.2872
+AGAAAC 60.230773 1.145967 1.026229 0.396633
+AGAAAG 64.468008 0.796966 0.839475 0.29345
+AGAAAT 63.270593 1.085246 1.137832 0.463063
+AGAACA 56.742545 0.867385 0.955006 0.356067
+AGAACC 54.085828 0.766921 1.031865 0.399905
+AGAACG 56.298816 0.859496 0.912157 0.332374
+AGAACT 55.819415 0.674029 0.907123 0.329626
+AGAAGA 64.197131 0.967221 0.859666 0.304101
+AGAAGC 60.401251 1.147071 1.053802 0.412726
+AGAAGG 63.333793 0.986078 0.910559 0.331501
+AGAAGT 62.274656 1.027094 1.315363 0.57556
+AGAATA 57.239885 0.934662 1.011537 0.388146
+AGAATC 53.967976 1.150044 1.325903 0.582492
+AGAATG 56.668889 1.108383 1.129767 0.458148
+AGAATT 55.67769 1.12299 1.235856 0.524173
+AGACAA 62.949256 0.878808 0.673923 0.211076
+AGACAC 60.665505 0.691304 0.617795 0.185263
+AGACAG 62.711202 1.013952 0.69807 0.222521
+AGACAT 62.604056 0.770839 0.692145 0.219694
+AGACCA 57.536546 0.853125 0.705434 0.226051
+AGACCC 55.62241 0.641836 0.75837 0.251967
+AGACCG 57.208761 0.871418 0.697301 0.222153
+AGACCT 57.104485 0.855965 0.704439 0.225573
+AGACGA 61.649285 0.866041 0.700612 0.223737
+AGACGC 60.051155 1.574633 0.689987 0.218667
+AGACGG 60.548917 1.026584 0.687678 0.217571
+AGACGT 59.888991 0.768385 0.815372 0.280903
+AGACTA 57.910166 0.634134 0.624521 0.188297
+AGACTC 55.469462 0.517802 0.620055 0.186281
+AGACTG 56.978084 0.546645 0.658217 0.20374
+AGACTT 56.01164 0.699557 0.912969 0.332818
+AGAGAA 68.197113 1.573 0.907686 0.329933
+AGAGAC 61.831905 0.718468 0.848248 0.298062
+AGAGAG 67.033447 1.429233 0.917927 0.335532
+AGAGAT 65.377009 0.864289 0.936065 0.345526
+AGAGCA 60.876461 1.000166 0.8335 0.290323
+AGAGCC 58.022439 0.729959 0.796494 0.271204
+AGAGCG 60.382114 0.912976 0.802022 0.274032
+AGAGCT 60.273639 1.028561 0.773804 0.259698
+AGAGGA 64.492242 0.81314 0.857171 0.302777
+AGAGGC 59.982095 0.718475 0.979098 0.369626
+AGAGGG 63.320829 0.816088 0.783611 0.264651
+AGAGGT 62.868736 0.716778 0.951012 0.353836
+AGAGTA 56.214154 0.719149 0.935458 0.345191
+AGAGTC 51.767758 0.989337 1.314863 0.575232
+AGAGTG 55.786594 0.918418 1.088643 0.433362
+AGAGTT 53.429801 1.15988 1.306415 0.569697
+AGATAA 57.596089 0.809415 0.695609 0.221345
+AGATAC 54.40916 0.698148 0.803192 0.274633
+AGATAG 57.204199 0.747829 0.711423 0.228936
+AGATAT 56.237818 0.701149 0.752236 0.248916
+AGATCA 51.520731 0.775896 0.919835 0.336579
+AGATCC 49.59893 0.863401 1.02926 0.398392
+AGATCG 51.347797 0.80439 0.892727 0.321811
+AGATCT 50.817271 0.729604 0.866134 0.307539
+AGATGA 53.978782 0.799087 0.930425 0.342409
+AGATGC 50.190884 0.828237 1.13471 0.461158
+AGATGG 53.531253 0.780324 0.802676 0.274368
+AGATGT 52.341666 0.671981 0.898985 0.325201
+AGATTA 49.038159 0.782695 1.050609 0.410851
+AGATTC 45.274562 0.754337 1.20546 0.504954
+AGATTG 48.371857 0.660969 0.981499 0.370986
+AGATTT 46.369006 0.901419 1.174787 0.485804
+AGCAAA 64.467173 0.893653 0.824219 0.285487
+AGCAAC 60.390266 1.001809 0.927445 0.340765
+AGCAAG 64.96913 0.651112 0.803442 0.274761
+AGCAAT 63.868911 0.857168 1.050335 0.41069
+AGCACA 62.235087 0.629051 0.688598 0.218007
+AGCACC 59.980118 0.644745 0.710345 0.228416
+AGCACG 61.880354 0.639231 0.694135 0.220642
+AGCACT 61.610056 0.570496 0.763201 0.254379
+AGCAGA 65.816229 0.898344 0.791989 0.268907
+AGCAGC 62.183544 0.970964 0.889387 0.320007
+AGCAGG 65.423897 0.727042 0.804853 0.275485
+AGCAGT 64.746808 0.959871 1.272408 0.547598
+AGCATA 62.073975 0.772669 0.766671 0.256115
+AGCATC 58.757974 1.142835 0.965567 0.36199
+AGCATG 61.363983 0.946605 0.927533 0.340814
+AGCATT 59.989827 1.305221 1.219133 0.513569
+AGCCAA 65.698828 0.721493 0.747257 0.246449
+AGCCAC 63.353709 0.667207 0.641556 0.196053
+AGCCAG 66.386504 0.826202 0.788342 0.267051
+AGCCAT 65.750988 0.690506 0.774643 0.260121
+AGCCCA 62.954316 0.870428 0.655724 0.202584
+AGCCCC 61.230156 0.67238 0.614438 0.183755
+AGCCCG 62.656733 0.793676 0.639985 0.195334
+AGCCCT 62.543378 0.756236 0.696613 0.221825
+AGCCGA 65.598608 0.826865 0.735055 0.240438
+AGCCGC 63.244355 0.742977 0.658098 0.203685
+AGCCGG 64.979926 0.786448 0.761086 0.253322
+AGCCGT 64.217836 0.725142 1.060457 0.416641
+AGCCTA 62.083852 0.591919 0.603421 0.178835
+AGCCTC 59.297961 0.591904 0.636509 0.193745
+AGCCTG 61.179608 0.706261 0.806344 0.276251
+AGCCTT 59.905622 0.753793 1.117715 0.450837
+AGCGAA 68.286478 0.985667 0.795493 0.270693
+AGCGAC 63.120435 0.67668 0.799076 0.272524
+AGCGAG 67.784538 0.927299 0.826067 0.286448
+AGCGAT 66.222813 0.887835 0.978787 0.369449
+AGCGCA 64.17693 1.215042 0.766782 0.256171
+AGCGCC 61.308067 0.624194 0.632789 0.192049
+AGCGCG 63.931155 1.428653 0.78998 0.267884
+AGCGCT 63.458069 0.947391 0.774589 0.260094
+AGCGGA 63.853032 0.883079 0.779913 0.26278
+AGCGGC 58.837411 0.937612 0.999855 0.381442
+AGCGGG 63.022543 0.859013 0.833531 0.290339
+AGCGGT 62.081147 0.874283 1.194921 0.498346
+AGCGTA 54.595721 1.256707 1.077128 0.426504
+AGCGTC 48.962212 1.523703 1.378959 0.617802
+AGCGTG 53.582623 1.438539 1.193851 0.497677
+AGCGTT 50.966372 1.687712 1.395177 0.628733
+AGCTAA 62.029781 0.960955 0.647148 0.198622
+AGCTAC 58.403458 0.608084 0.674 0.211112
+AGCTAG 61.642885 0.713505 0.659903 0.204523
+AGCTAT 60.412712 0.621112 0.668684 0.208619
+AGCTCA 57.149124 0.694946 0.649952 0.199915
+AGCTCC 55.013417 0.61013 0.728845 0.237397
+AGCTCG 57.026902 0.63146 0.660329 0.204721
+AGCTCT 56.243195 0.649748 0.651225 0.200502
+AGCTGA 55.541694 0.949807 0.844938 0.29632
+AGCTGC 50.730766 0.835388 1.07569 0.425651
+AGCTGG 55.694942 0.703641 0.764622 0.255089
+AGCTGT 54.121182 0.752657 0.969459 0.36418
+AGCTTA 50.834724 0.817621 1.015271 0.390297
+AGCTTC 45.824604 0.936337 1.26973 0.545871
+AGCTTG 50.0876 0.758779 0.947693 0.351985
+AGCTTT 47.283343 1.05831 1.20896 0.507155
+AGGAAA 74.254272 1.217809 1.398274 0.630828
+AGGAAC 68.457401 1.240179 1.244317 0.529565
+AGGAAG 74.26124 1.116423 1.41708 0.643597
+AGGAAT 72.793933 1.211217 1.625094 0.790388
+AGGACA 62.60366 0.764334 0.75542 0.250499
+AGGACC 58.959975 0.693881 0.860041 0.304299
+AGGACG 61.449612 0.882305 0.766286 0.255923
+AGGACT 61.066246 0.797109 0.918407 0.335796
+AGGAGA 72.336683 1.275479 1.307718 0.57055
+AGGAGC 66.47677 1.205866 1.127962 0.457051
+AGGAGG 71.207049 1.285073 1.333625 0.587589
+AGGAGT 69.722682 1.293476 1.667874 0.821802
+AGGATA 62.327038 1.093378 1.048229 0.409456
+AGGATC 58.305098 1.314979 1.240345 0.527031
+AGGATG 61.616727 1.176536 1.151469 0.471412
+AGGATT 60.331584 1.432043 1.369559 0.611496
+AGGCAA 70.993549 0.89826 1.101848 0.441271
+AGGCAC 68.350313 0.895625 1.052358 0.411877
+AGGCAG 71.142939 0.954197 1.032238 0.400122
+AGGCAT 70.394421 0.93563 1.26272 0.541356
+AGGCCA 65.114294 0.757238 0.717736 0.23199
+AGGCCC 62.994454 0.61281 0.719259 0.232729
+AGGCCG 64.726218 0.703516 0.739261 0.242504
+AGGCCT 64.273734 0.639226 0.808097 0.277152
+AGGCGA 70.42721 0.929298 0.995176 0.378767
+AGGCGC 66.929834 0.807599 1.007524 0.385838
+AGGCGG 68.926368 0.951814 1.0861 0.431844
+AGGCGT 67.661317 0.898664 1.462988 0.675124
+AGGCTA 65.257636 0.919191 0.974394 0.366965
+AGGCTC 62.256335 1.392031 0.979862 0.370058
+AGGCTG 64.372774 0.889619 1.150002 0.470512
+AGGCTT 63.659257 1.073941 1.387832 0.623775
+AGGGAA 73.474294 1.650206 1.318834 0.57784
+AGGGAC 65.669035 0.800253 0.982299 0.371439
+AGGGAG 72.224713 1.601201 1.304025 0.568135
+AGGGAT 70.101814 1.247513 1.274615 0.549024
+AGGGCA 64.967912 1.425378 1.032271 0.400141
+AGGGCC 61.483757 0.754984 0.873726 0.311591
+AGGGCG 64.378648 1.429958 1.009084 0.386735
+AGGGCT 64.621848 1.473549 1.052493 0.411957
+AGGGGA 68.314855 1.062802 1.019789 0.392905
+AGGGGC 62.018826 0.834672 0.936224 0.345615
+AGGGGG 67.302407 0.983912 1.033517 0.400866
+AGGGGT 66.649066 0.867878 1.116276 0.449966
+AGGGTA 60.173932 0.86139 0.951377 0.354039
+AGGGTC 54.706379 1.201169 1.250389 0.533446
+AGGGTG 59.39714 0.991409 1.045147 0.407651
+AGGGTT 56.811396 1.21402 1.258206 0.538456
+AGGTAA 59.379495 1.006972 0.821121 0.283879
+AGGTAC 55.287515 0.590951 0.835916 0.291586
+AGGTAG 59.064656 1.198906 0.830625 0.288822
+AGGTAT 57.51335 0.892748 0.825326 0.286062
+AGGTCA 51.330697 0.923825 0.945355 0.350683
+AGGTCC 49.063351 0.665348 0.993969 0.378078
+AGGTCG 50.808675 0.831097 0.933239 0.343963
+AGGTCT 50.143531 0.689119 0.852409 0.300258
+AGGTGA 55.280153 0.858096 0.883161 0.316652
+AGGTGC 51.416014 0.72725 0.961556 0.359736
+AGGTGG 54.763141 0.828884 0.82102 0.283827
+AGGTGT 53.46973 0.614215 0.854575 0.301403
+AGGTTA 49.3736 0.654856 0.896781 0.324005
+AGGTTC 45.647034 0.761442 1.012425 0.388657
+AGGTTG 48.705511 0.648176 0.860509 0.304548
+AGGTTT 46.850044 0.907742 1.025241 0.39606
+AGTAAA 63.225932 0.809774 0.773652 0.259622
+AGTAAC 59.68682 0.622024 0.693271 0.22023
+AGTAAG 63.701934 0.861099 0.857578 0.302993
+AGTAAT 62.47141 0.791549 0.861983 0.305331
+AGTACA 58.753149 0.992785 0.890512 0.320614
+AGTACC 56.676988 0.808572 0.700704 0.223782
+AGTACG 58.501247 0.952037 0.816267 0.281366
+AGTACT 58.317795 1.041788 0.794108 0.269987
+AGTAGA 62.85675 0.838826 0.848445 0.298166
+AGTAGC 59.615625 0.636264 0.736707 0.241249
+AGTAGG 62.472601 0.804034 0.779861 0.262754
+AGTAGT 61.730049 0.747771 0.943768 0.3498
+AGTATA 58.316382 0.629395 0.630121 0.190835
+AGTATC 55.535557 0.775173 0.766195 0.255877
+AGTATG 57.83928 0.702701 0.763812 0.254684
+AGTATT 56.655348 0.702233 0.994132 0.378171
+AGTCAA 60.455514 1.286819 1.112821 0.447879
+AGTCAC 58.646367 0.998135 0.889027 0.319812
+AGTCAG 60.644186 1.492516 1.238368 0.525772
+AGTCAT 60.661908 1.249739 1.117924 0.450963
+AGTCCA 56.290273 1.408451 1.068597 0.421448
+AGTCCC 54.881395 1.142804 0.967739 0.363212
+AGTCCG 56.254066 1.337417 1.041076 0.405272
+AGTCCT 55.680614 1.216091 0.99578 0.379112
+AGTCGA 59.895356 1.299122 1.11647 0.450083
+AGTCGC 57.797545 0.828017 0.935217 0.345057
+AGTCGG 59.108302 1.413988 1.15066 0.470916
+AGTCGT 58.569611 1.123383 1.160823 0.477168
+AGTCTA 56.18721 0.912021 0.890446 0.320578
+AGTCTC 54.451319 0.584716 0.659487 0.20433
+AGTCTG 55.62404 0.915803 0.851596 0.299828
+AGTCTT 54.619359 0.769052 0.908652 0.33046
+AGTGAA 60.662032 1.768204 1.064476 0.419012
+AGTGAC 55.196278 0.93245 0.731747 0.238816
+AGTGAG 59.34952 1.57323 1.014458 0.389829
+AGTGAT 58.606878 1.601043 1.01372 0.389403
+AGTGCA 55.633496 1.634087 1.093305 0.436149
+AGTGCC 53.045717 1.284142 0.960155 0.358951
+AGTGCG 55.063637 1.810337 1.122212 0.45356
+AGTGCT 54.97557 1.349446 0.991466 0.376651
+AGTGGA 58.392657 1.123772 1.023133 0.39484
+AGTGGC 54.827028 0.642501 0.791349 0.268581
+AGTGGG 57.359062 0.980305 0.880666 0.315311
+AGTGGT 57.309687 0.871279 0.906948 0.329531
+AGTGTA 52.00245 0.706442 0.756574 0.251073
+AGTGTC 47.632956 0.856184 0.815106 0.280766
+AGTGTG 51.302357 0.760398 0.74572 0.245689
+AGTGTT 49.08467 0.971159 0.806821 0.276496
+AGTTAA 54.634038 1.328162 0.90374 0.327784
+AGTTAC 51.595119 0.853952 0.787212 0.266477
+AGTTAG 54.407463 1.117104 0.907907 0.330054
+AGTTAT 53.187372 1.152192 0.786762 0.266249
+AGTTCA 48.44234 1.173426 0.992411 0.37719
+AGTTCC 46.475353 1.03639 0.922917 0.338272
+AGTTCG 48.319915 1.257893 0.967822 0.363259
+AGTTCT 47.658301 1.004797 0.849505 0.298725
+AGTTGA 50.818349 0.789434 0.912627 0.332631
+AGTTGC 47.693302 0.594717 0.883874 0.317036
+AGTTGG 50.392272 0.882061 0.780126 0.262887
+AGTTGT 49.753938 0.899046 0.71608 0.231188
+AGTTTA 46.157104 0.68747 0.864083 0.306447
+AGTTTC 42.959916 0.555815 0.740291 0.243011
+AGTTTG 45.680998 0.591913 0.686598 0.217058
+AGTTTT 43.948235 0.472023 0.627611 0.189696
+ATAAAA 63.386105 0.835165 0.700684 0.223772
+ATAAAC 58.63932 0.744152 0.738875 0.242314
+ATAAAG 63.362413 0.703088 0.701063 0.223954
+ATAAAT 61.916029 0.707864 0.904754 0.328336
+ATAACA 57.433544 0.614642 0.673559 0.210905
+ATAACC 54.992526 0.609028 0.719804 0.232993
+ATAACG 57.077599 0.59695 0.648812 0.199389
+ATAACT 56.642084 0.530377 0.642178 0.196339
+ATAAGA 63.954869 0.934095 0.727182 0.236585
+ATAAGC 59.561156 0.780202 0.803261 0.274668
+ATAAGG 62.890434 0.695671 0.77581 0.260709
+ATAAGT 61.939179 0.980304 1.12911 0.457748
+ATAATA 57.543176 0.752572 0.745147 0.245406
+ATAATC 54.2643 1.046514 0.93973 0.347558
+ATAATG 56.944047 0.832408 0.83323 0.290182
+ATAATT 55.763992 1.086015 0.991943 0.376923
+ATACAA 65.251499 0.908598 0.773144 0.259366
+ATACAC 62.650852 0.650557 0.639376 0.195055
+ATACAG 65.527158 1.072015 0.856852 0.302608
+ATACAT 64.815368 0.777656 0.803151 0.274611
+ATACCA 60.906452 0.895684 0.704341 0.225526
+ATACCC 59.022918 0.672366 0.652265 0.200983
+ATACCG 60.691559 0.875389 0.697051 0.222034
+ATACCT 60.279457 0.754697 0.713685 0.230029
+ATACGA 64.47568 0.842382 0.749825 0.247721
+ATACGC 61.554714 0.655442 0.677143 0.21259
+ATACGG 63.684352 0.869954 0.795437 0.270664
+ATACGT 62.5143 0.844337 1.006442 0.385217
+ATACTA 60.273857 0.745572 0.603773 0.178992
+ATACTC 57.848818 1.082781 0.645576 0.197899
+ATACTG 59.513627 0.644538 0.743112 0.244402
+ATACTT 58.258762 0.859236 1.011609 0.388187
+ATAGAA 66.424465 1.164007 0.869208 0.309178
+ATAGAC 60.237573 0.668895 0.694735 0.220928
+ATAGAG 65.538321 1.131764 0.855783 0.302043
+ATAGAT 63.891398 0.903624 0.82389 0.285316
+ATAGCA 61.176553 1.199011 0.762267 0.253912
+ATAGCC 57.9508 0.605501 0.658585 0.203911
+ATAGCG 60.780909 1.04833 0.749754 0.247685
+ATAGCT 60.56045 1.358709 0.800074 0.273035
+ATAGGA 63.315048 0.809899 0.833827 0.290494
+ATAGGC 58.25913 0.695478 0.860519 0.304553
+ATAGGG 62.555445 0.962271 0.702904 0.224836
+ATAGGT 61.621855 0.796766 0.845072 0.29639
+ATAGTA 55.012823 0.799164 0.854201 0.301205
+ATAGTC 50.030712 1.10647 1.103924 0.442518
+ATAGTG 54.450766 0.975158 0.891619 0.321212
+ATAGTT 51.671285 1.097291 1.065075 0.419366
+ATATAA 59.559274 0.794005 0.61427 0.18368
+ATATAC 55.826644 0.604531 0.647615 0.198837
+ATATAG 59.305038 0.782843 0.628218 0.189972
+ATATAT 57.832529 0.775779 0.64217 0.196335
+ATATCA 53.698373 0.632009 0.693676 0.220423
+ATATCC 51.69701 0.620892 0.807314 0.276749
+ATATCG 53.605403 0.642948 0.665599 0.207177
+ATATCT 52.855761 0.499266 0.600677 0.177617
+ATATGA 54.730834 0.760296 0.7909 0.268352
+ATATGC 50.348172 0.788075 1.038141 0.403559
+ATATGG 54.478428 0.678716 0.706148 0.226395
+ATATGT 52.876754 0.6248 0.785177 0.265444
+ATATTA 49.644292 0.709849 0.9293 0.341788
+ATATTC 45.354867 0.826538 1.110415 0.446427
+ATATTG 48.977367 0.602054 0.860919 0.304766
+ATATTT 46.529059 0.870984 0.98549 0.373251
+ATCAAA 63.27801 0.928402 0.828614 0.287774
+ATCAAC 58.876326 0.743568 0.815066 0.280745
+ATCAAG 63.845619 0.690607 0.811211 0.278755
+ATCAAT 62.585281 0.722975 0.949958 0.353248
+ATCACA 61.76725 0.685843 0.720096 0.233135
+ATCACC 59.581612 0.600616 0.660602 0.204848
+ATCACG 61.354614 0.662814 0.687766 0.217612
+ATCACT 61.16054 0.639362 0.716677 0.231477
+ATCAGA 65.076023 0.827719 0.859703 0.30412
+ATCAGC 61.352892 1.1224 0.847265 0.297544
+ATCAGG 64.771235 0.702218 0.862051 0.305367
+ATCAGT 64.102488 0.79479 1.213877 0.510252
+ATCATA 61.514659 0.783772 0.780345 0.262998
+ATCATC 58.237591 0.990356 0.868927 0.309028
+ATCATG 60.775153 1.028514 0.912515 0.33257
+ATCATT 59.441265 1.097454 1.068111 0.42116
+ATCCAA 65.526968 0.908917 0.920363 0.336869
+ATCCAC 63.108606 0.712132 0.725376 0.235704
+ATCCAG 66.682836 0.956614 0.977135 0.368514
+ATCCAT 65.679975 0.858696 0.959484 0.358575
+ATCCCA 63.3981 1.164807 0.904713 0.328314
+ATCCCC 61.518579 0.762968 0.772481 0.259033
+ATCCCG 63.068103 1.150484 0.912895 0.332778
+ATCCCT 62.803678 1.08681 0.89468 0.322867
+ATCCGA 66.043262 1.000988 0.914899 0.333874
+ATCCGC 63.072992 0.600391 0.703726 0.225231
+ATCCGG 65.450411 0.944223 0.958004 0.357745
+ATCCGT 64.241115 0.916102 1.241842 0.527986
+ATCCTA 62.116536 0.714806 0.665619 0.207187
+ATCCTC 59.427581 0.902502 0.753985 0.249785
+ATCCTG 61.125688 0.766068 0.911814 0.332186
+ATCCTT 59.971901 0.820936 1.155793 0.47407
+ATCGAA 67.345716 1.142049 0.992196 0.377067
+ATCGAC 62.183363 0.663764 0.742367 0.244034
+ATCGAG 67.006285 1.084526 0.951596 0.354162
+ATCGAT 65.188044 0.816857 0.969218 0.364045
+ATCGCA 63.769461 1.210298 0.828217 0.287567
+ATCGCC 61.19839 0.740036 0.624877 0.188458
+ATCGCG 63.46967 1.145823 0.818669 0.282608
+ATCGCT 63.212697 1.07301 0.854956 0.301605
+ATCGGA 63.214577 0.928294 0.841277 0.294396
+ATCGGC 57.885524 0.935889 0.926817 0.340419
+ATCGGG 62.554579 0.836982 0.903775 0.327803
+ATCGGT 61.515292 0.950158 1.110967 0.44676
+ATCGTA 53.582794 1.449594 1.058825 0.41568
+ATCGTC 47.835643 1.506213 1.229654 0.520232
+ATCGTG 52.813544 1.344966 1.113535 0.44831
+ATCGTT 49.820518 1.618248 1.261631 0.540656
+ATCTAA 61.940132 0.777223 0.763171 0.254364
+ATCTAC 58.24155 0.569638 0.616708 0.184774
+ATCTAG 62.115584 0.747804 0.765989 0.255774
+ATCTAT 60.253401 0.592777 0.729828 0.237878
+ATCTCA 57.708605 0.834443 0.670602 0.209517
+ATCTCC 55.657292 0.972067 0.637459 0.194179
+ATCTCG 57.677867 0.884958 0.658635 0.203934
+ATCTCT 56.654525 0.696017 0.604452 0.179294
+ATCTGA 55.172128 1.091255 0.766607 0.256084
+ATCTGC 50.10542 0.826061 0.883708 0.316946
+ATCTGG 55.445601 0.644513 0.673704 0.210973
+ATCTGT 53.743262 0.650911 0.80475 0.275432
+ATCTTA 50.287658 0.762906 0.792137 0.268982
+ATCTTC 45.038129 0.791495 0.963521 0.36084
+ATCTTG 49.568057 0.726774 0.745635 0.245647
+ATCTTT 46.467942 0.958662 0.912976 0.332822
+ATGAAA 69.238096 1.108916 1.218111 0.512924
+ATGAAC 64.006301 0.95796 1.113678 0.448396
+ATGAAG 69.329991 1.221078 1.261962 0.540869
+ATGAAT 67.681571 1.158423 1.410167 0.638893
+ATGACA 60.032615 0.791316 0.733652 0.239749
+ATGACC 57.171149 0.639438 0.72884 0.237395
+ATGACG 59.582833 0.736831 0.72076 0.233458
+ATGACT 59.197824 0.644235 0.77503 0.260315
+ATGAGA 67.547194 1.018045 1.06402 0.418742
+ATGAGC 62.209965 0.976273 1.087034 0.432401
+ATGAGG 66.436731 1.062162 1.088762 0.433433
+ATGAGT 65.002321 0.989224 1.408464 0.637736
+ATGATA 59.317945 0.890209 1.016831 0.391197
+ATGATC 54.984423 1.055501 1.041432 0.40548
+ATGATG 58.562561 1.019335 1.035573 0.402063
+ATGATT 56.784133 1.33391 1.120818 0.452715
+ATGCAA 68.782903 1.026093 1.168664 0.482011
+ATGCAC 65.766213 0.873541 0.963719 0.360951
+ATGCAG 69.125857 1.12089 1.241653 0.527865
+ATGCAT 68.024762 1.123306 1.296745 0.563384
+ATGCCA 63.96986 1.023014 0.957538 0.357484
+ATGCCC 61.816124 0.758583 0.790521 0.268159
+ATGCCG 63.611197 1.077961 0.957561 0.357497
+ATGCCT 63.262742 0.891559 0.918209 0.335687
+ATGCGA 68.257834 1.115057 1.113549 0.448319
+ATGCGC 64.563552 0.762839 0.878013 0.313887
+ATGCGG 66.845455 1.073795 1.149275 0.470066
+ATGCGT 65.323784 1.151257 1.408988 0.638093
+ATGCTA 63.117535 0.714706 0.853671 0.300925
+ATGCTC 60.179343 0.836023 1.017949 0.391842
+ATGCTG 62.026863 0.919611 1.104887 0.443097
+ATGCTT 61.032077 0.998497 1.369619 0.611536
+ATGGAA 67.674336 1.739149 1.345601 0.595521
+ATGGAC 60.047948 1.057724 0.833539 0.290343
+ATGGAG 66.510205 1.700937 1.290505 0.559322
+ATGGAT 64.535342 1.230543 1.190106 0.495337
+ATGGCA 61.354563 1.464871 0.997575 0.380138
+ATGGCC 58.290098 1.052074 0.841461 0.294492
+ATGGCG 60.833456 1.449351 0.992688 0.377348
+ATGGCT 60.505789 1.326038 0.977609 0.368783
+ATGGGA 61.744068 1.122788 1.072079 0.423509
+ATGGGC 55.324746 0.776907 1.027253 0.397227
+ATGGGG 60.899205 0.956752 0.933624 0.344176
+ATGGGT 60.343199 0.862844 0.980288 0.3703
+ATGGTA 53.669737 0.754724 0.906081 0.329059
+ATGGTC 48.106635 0.879067 1.053741 0.41269
+ATGGTG 53.088375 0.761945 0.906101 0.32907
+ATGGTT 50.154233 0.93309 1.05426 0.412995
+ATGTAA 55.31356 1.059916 0.816151 0.281306
+ATGTAC 51.16351 0.607944 0.784024 0.26486
+ATGTAG 54.711466 1.106584 0.817889 0.282205
+ATGTAT 53.314382 0.858521 0.731518 0.238704
+ATGTCA 47.837758 1.022102 0.968168 0.363454
+ATGTCC 45.432956 0.749493 0.91605 0.334504
+ATGTCG 47.566888 0.98897 0.924072 0.338908
+ATGTCT 46.796345 0.817119 0.854124 0.301165
+ATGTGA 50.928727 0.751884 0.880469 0.315205
+ATGTGC 46.910791 0.658888 0.917039 0.335046
+ATGTGG 50.143428 0.933028 0.804009 0.275051
+ATGTGT 49.155491 0.655957 0.71547 0.230892
+ATGTTA 45.539339 0.636818 0.911272 0.33189
+ATGTTC 42.138196 0.695839 0.916691 0.334855
+ATGTTG 45.012697 0.56504 0.755111 0.250345
+ATGTTT 43.140937 0.678479 0.796974 0.271449
+ATTAAA 63.424911 0.887786 0.836478 0.29188
+ATTAAC 59.623794 0.68113 0.749245 0.247433
+ATTAAG 64.229886 0.94513 0.933767 0.344255
+ATTAAT 62.722277 0.899002 0.948453 0.352408
+ATTACA 59.873607 1.169141 1.001928 0.382629
+ATTACC 57.670343 0.793893 0.750428 0.24802
+ATTACG 59.58598 1.091223 0.964792 0.361554
+ATTACT 59.382115 1.074527 0.847388 0.297609
+ATTAGA 63.299754 0.824466 0.866841 0.307916
+ATTAGC 59.7845 0.669332 0.75295 0.249271
+ATTAGG 63.061528 0.904243 0.936102 0.345547
+ATTAGT 62.158365 0.855361 1.050031 0.410512
+ATTATA 58.750516 0.636462 0.694578 0.220853
+ATTATC 55.769107 0.777246 0.834349 0.290766
+ATTATG 58.202992 0.663238 0.828481 0.287704
+ATTATT 56.897853 0.819163 1.025339 0.396117
+ATTCAA 62.371857 1.087501 1.165873 0.480286
+ATTCAC 59.948322 1.026539 0.883335 0.316746
+ATTCAG 62.794904 1.567049 1.339057 0.591182
+ATTCAT 62.345333 1.132054 1.214866 0.510876
+ATTCCA 58.648208 1.514848 1.260502 0.539931
+ATTCCC 56.811588 1.195014 1.174276 0.485487
+ATTCCG 58.369545 1.354287 1.298886 0.56478
+ATTCCT 57.907477 1.438037 1.149288 0.470073
+ATTCGA 61.776023 1.257635 1.270857 0.546597
+ATTCGC 59.532069 0.878533 0.968169 0.363454
+ATTCGG 61.287059 1.460821 1.257483 0.537992
+ATTCGT 60.260217 1.237438 1.313008 0.574016
+ATTCTA 57.687988 0.956328 0.960853 0.359342
+ATTCTC 55.528709 0.6084 0.721128 0.233637
+ATTCTG 57.065261 0.863007 0.973772 0.366613
+ATTCTT 55.640491 0.991735 1.039667 0.404449
+ATTGAA 60.796471 1.776918 1.211837 0.508966
+ATTGAC 54.962096 0.969588 0.776472 0.261043
+ATTGAG 59.26305 1.916833 1.116908 0.450349
+ATTGAT 58.37353 1.640008 1.074475 0.42493
+ATTGCA 56.382925 1.75134 1.123234 0.45418
+ATTGCC 53.697271 1.334828 0.952423 0.354623
+ATTGCG 55.738297 1.735313 1.112488 0.447678
+ATTGCT 55.479389 1.44049 1.010493 0.387545
+ATTGGA 58.115863 1.131105 1.143443 0.466492
+ATTGGC 54.417449 0.657942 0.846826 0.297313
+ATTGGG 57.382873 1.033017 0.944307 0.3501
+ATTGGT 56.903046 0.943692 0.952497 0.354665
+ATTGTA 51.550547 0.829552 0.764737 0.255147
+ATTGTC 46.264302 0.828375 0.843173 0.295391
+ATTGTG 50.468391 0.880678 0.752035 0.248817
+ATTGTT 48.124873 0.875848 0.813347 0.279857
+ATTTAA 55.385817 1.426527 1.051174 0.411183
+ATTTAC 52.074581 0.944737 0.871866 0.310597
+ATTTAG 55.15034 1.374077 1.055348 0.413634
+ATTTAT 53.746074 1.238182 0.933259 0.343974
+ATTTCA 49.294386 1.305996 0.970564 0.364803
+ATTTCC 47.248511 1.097188 0.953903 0.35545
+ATTTCG 49.120382 1.323968 0.965097 0.361725
+ATTTCT 48.427276 1.07115 0.799675 0.27283
+ATTTGA 50.859568 0.877719 0.944109 0.34999
+ATTTGC 47.591699 0.611295 0.865125 0.307002
+ATTTGG 50.795148 0.837986 0.812219 0.279275
+ATTTGT 49.810672 0.743054 0.716269 0.231279
+ATTTTA 46.199925 0.682992 0.840885 0.29419
+ATTTTC 42.731564 0.542663 0.712111 0.229268
+ATTTTG 45.689727 0.588265 0.61122 0.182313
+ATTTTT 43.684395 0.545238 0.588033 0.172038
+CAAAAA 62.2091 0.699513 0.698845 0.222892
+CAAAAC 57.638362 0.722039 0.741645 0.243678
+CAAAAG 62.366344 0.655445 0.724395 0.235226
+CAAAAT 60.929376 0.682558 0.861676 0.305168
+CAAACA 55.756408 0.709302 0.793144 0.269495
+CAAACC 53.537051 0.74306 0.912525 0.332575
+CAAACG 55.494111 0.686135 0.73881 0.242282
+CAAACT 54.998423 0.598127 0.683717 0.215693
+CAAAGA 62.242782 0.870792 0.742275 0.243989
+CAAAGC 58.055832 0.663908 0.794051 0.269957
+CAAAGG 61.425921 0.678429 0.724198 0.23513
+CAAAGT 60.347068 0.731174 0.979857 0.370055
+CAAATA 55.740476 0.624326 0.757118 0.251344
+CAAATC 52.226886 0.938243 0.917806 0.335466
+CAAATG 55.165815 0.716451 0.821921 0.284294
+CAAATT 53.568405 1.11819 0.973787 0.366622
+CAACAA 63.068877 0.987752 0.797549 0.271743
+CAACAC 60.753256 0.63115 0.654579 0.202053
+CAACAG 63.319181 1.186429 0.877613 0.313673
+CAACAT 62.994837 0.921069 0.883777 0.316984
+CAACCA 58.724674 1.014838 0.813016 0.279686
+CAACCC 56.951768 0.899098 0.779035 0.262336
+CAACCG 58.563478 1.06996 0.806451 0.276306
+CAACCT 57.97811 0.776247 0.719556 0.232873
+CAACGA 62.283864 1.078261 0.857559 0.302983
+CAACGC 59.614352 0.680989 0.744838 0.245254
+CAACGG 61.338879 1.041148 0.830669 0.288845
+CAACGT 60.571094 0.836785 0.948165 0.352248
+CAACTA 58.16877 0.603489 0.632625 0.191974
+CAACTC 55.686783 0.591471 0.617707 0.185224
+CAACTG 57.384551 0.575622 0.661783 0.205398
+CAACTT 55.795206 0.946451 0.883383 0.316771
+CAAGAA 66.613682 1.12998 0.888093 0.319308
+CAAGAC 59.940965 0.624964 0.702008 0.224407
+CAAGAG 65.719282 1.402624 0.891391 0.321088
+CAAGAT 63.961961 0.994997 0.890648 0.320687
+CAAGCA 60.68362 1.277318 0.885082 0.317686
+CAAGCC 57.192408 0.734688 0.762132 0.253845
+CAAGCG 60.207699 1.456416 0.893785 0.322383
+CAAGCT 59.834886 1.539314 0.839162 0.293286
+CAAGGA 62.94637 0.98638 0.836344 0.29181
+CAAGGC 58.188 0.87741 0.925045 0.339443
+CAAGGG 61.715144 0.677813 0.734862 0.240343
+CAAGGT 61.225814 0.696499 0.855888 0.302098
+CAAGTA 54.221035 0.765203 0.946039 0.351064
+CAAGTC 48.751129 1.095527 1.174053 0.485349
+CAAGTG 53.407779 0.994344 1.003904 0.383761
+CAAGTT 50.552418 1.043829 1.094942 0.437129
+CAATAA 57.81306 1.03547 0.725535 0.235782
+CAATAC 54.176865 0.642781 0.767628 0.256595
+CAATAG 57.437105 0.895123 0.734108 0.239973
+CAATAT 56.088118 0.681359 0.71956 0.232875
+CAATCA 51.972762 0.747713 0.864273 0.306548
+CAATCC 49.960867 0.744067 0.953156 0.355033
+CAATCG 51.873712 0.745209 0.855783 0.302043
+CAATCT 51.091925 0.620588 0.738362 0.242062
+CAATGA 53.047597 0.782151 0.995575 0.378995
+CAATGC 49.183231 0.980471 1.206932 0.505879
+CAATGG 52.980378 0.653922 0.802386 0.274219
+CAATGT 51.707245 0.590328 0.808979 0.277606
+CAATTA 48.706121 0.965898 1.121082 0.452875
+CAATTC 44.600986 0.860983 1.286271 0.556572
+CAATTG 47.922251 0.667973 0.923085 0.338365
+CAATTT 45.385917 0.690673 1.088699 0.433396
+CACAAA 64.187489 1.035385 0.812517 0.279429
+CACAAC 59.854248 0.892764 0.854141 0.301173
+CACAAG 65.018693 0.635073 0.767969 0.256766
+CACAAT 63.560404 0.768233 0.97924 0.369706
+CACACA 62.674815 0.673598 0.674088 0.211153
+CACACC 60.287782 0.513814 0.678757 0.213351
+CACACG 62.418348 0.661636 0.662108 0.205549
+CACACT 61.993985 0.556212 0.684684 0.216151
+CACAGA 65.963702 0.981639 0.797048 0.271487
+CACAGC 61.796529 0.960838 0.820058 0.283328
+CACAGG 65.654337 0.735039 0.833787 0.290473
+CACAGT 64.699753 1.129878 1.296758 0.563392
+CACATA 62.048827 0.845088 0.71798 0.232108
+CACATC 58.516532 1.095681 0.890674 0.320701
+CACATG 61.379647 0.899802 0.892471 0.321672
+CACATT 59.783408 1.128591 1.106663 0.444166
+CACCAA 66.558438 0.774329 0.794002 0.269932
+CACCAC 63.939545 0.62897 0.655143 0.202314
+CACCAG 67.455356 0.814642 0.858788 0.303635
+CACCAT 66.591442 0.734788 0.846724 0.297259
+CACCCA 64.229571 0.854606 0.729701 0.237815
+CACCCC 62.288117 0.618138 0.608007 0.180878
+CACCCG 64.196548 0.864247 0.718865 0.232538
+CACCCT 63.713862 0.762762 0.735558 0.240684
+CACCGA 66.801943 0.815448 0.756968 0.251269
+CACCGC 63.874429 0.608181 0.636154 0.193582
+CACCGG 66.186656 0.747899 0.829638 0.288307
+CACCGT 65.147264 0.801073 1.206319 0.505494
+CACCTA 62.91979 0.595243 0.618252 0.185469
+CACCTC 59.908286 0.706491 0.640572 0.195602
+CACCTG 61.920821 0.683169 0.840978 0.294239
+CACCTT 60.216951 1.015498 1.052266 0.411823
+CACGAA 68.607135 0.959425 0.875567 0.312577
+CACGAC 62.951234 0.652169 0.704218 0.225467
+CACGAG 68.183529 0.938381 0.905639 0.328818
+CACGAT 66.329212 0.76536 0.959612 0.358646
+CACGCA 64.560457 1.093183 0.76686 0.25621
+CACGCC 61.865198 0.639975 0.638068 0.194457
+CACGCG 64.494411 1.253334 0.774655 0.260127
+CACGCT 63.940764 1.048507 0.830876 0.288953
+CACGGA 63.771858 1.116704 0.770545 0.258059
+CACGGC 58.429943 0.90948 0.964364 0.361313
+CACGGG 62.944873 0.930361 0.821623 0.284139
+CACGGT 62.089731 0.898632 1.124802 0.455132
+CACGTA 53.768187 1.263189 1.099081 0.43961
+CACGTC 47.67125 1.580318 1.342887 0.59372
+CACGTG 52.910421 1.305669 1.195322 0.498597
+CACGTT 49.906814 1.582466 1.310889 0.572627
+CACTAA 62.521572 0.740079 0.643006 0.196718
+CACTAC 58.507607 0.559343 0.614681 0.183864
+CACTAG 62.618379 0.882257 0.747594 0.246616
+CACTAT 60.793414 0.661685 0.672836 0.210565
+CACTCA 57.782345 0.820664 0.697157 0.222085
+CACTCC 55.500575 0.553402 0.689438 0.218407
+CACTCG 57.720505 0.772288 0.679488 0.213695
+CACTCT 56.683291 0.539823 0.63552 0.193293
+CACTGA 55.229652 1.102943 0.840414 0.293943
+CACTGC 50.398817 0.829971 1.115719 0.44963
+CACTGG 55.592047 0.636927 0.74362 0.244652
+CACTGT 54.037122 0.681384 0.934756 0.344802
+CACTTA 50.538231 0.846994 1.011401 0.388068
+CACTTC 45.344682 0.924766 1.279813 0.552386
+CACTTG 49.755536 0.681782 0.952366 0.354591
+CACTTT 46.637737 0.935384 1.149648 0.470295
+CAGAAA 68.623639 0.824757 1.004153 0.383904
+CAGAAC 63.01717 1.033783 0.915374 0.334134
+CAGAAG 68.848883 0.843398 1.03364 0.400937
+CAGAAT 67.145386 0.895103 1.29217 0.560405
+CAGACA 59.941408 1.25805 0.709393 0.227957
+CAGACC 56.167444 0.570271 0.70107 0.223957
+CAGACG 58.851832 0.688886 0.695764 0.221419
+CAGACT 58.188075 0.627067 0.684644 0.216132
+CAGAGA 66.949261 0.945413 0.905048 0.328496
+CAGAGC 61.425012 0.90275 0.875789 0.312696
+CAGAGG 66.145393 0.811492 0.927729 0.340921
+CAGAGT 64.316262 1.665245 1.115398 0.449436
+CAGATA 57.989003 0.809389 0.804778 0.275446
+CAGATC 53.906555 1.006858 1.044252 0.407128
+CAGATG 57.461243 0.856276 0.891081 0.320921
+CAGATT 55.499601 1.137223 1.099646 0.439949
+CAGCAA 67.460867 0.722843 0.869697 0.309438
+CAGCAC 64.636964 0.628118 0.797852 0.271898
+CAGCAG 67.825836 0.82885 0.887934 0.319223
+CAGCAT 66.796587 0.848777 0.978231 0.369135
+CAGCCA 62.361998 0.799214 0.726413 0.23621
+CAGCCC 60.34696 0.552321 0.661222 0.205137
+CAGCCG 62.064436 0.786631 0.728291 0.237127
+CAGCCT 61.787819 0.717455 0.71647 0.231377
+CAGCGA 66.831416 0.838248 0.803808 0.274948
+CAGCGC 63.28578 0.607839 0.765443 0.2555
+CAGCGG 65.723884 0.758166 0.849189 0.298558
+CAGCGT 64.325754 0.780242 1.197054 0.499681
+CAGCTA 61.893814 0.595543 0.741381 0.243548
+CAGCTC 58.671273 1.028594 0.746019 0.245837
+CAGCTG 60.98366 0.671331 0.916819 0.334925
+CAGCTT 59.522785 1.949212 1.058252 0.415342
+CAGGAA 70.776431 1.678645 1.215988 0.511584
+CAGGAC 62.888849 1.278881 0.821432 0.28404
+CAGGAG 69.680559 1.74469 1.195873 0.498942
+CAGGAT 67.553968 1.185669 1.152502 0.472047
+CAGGCA 63.853248 1.799111 1.127167 0.456568
+CAGGCC 60.178945 1.133169 0.876312 0.312976
+CAGGCG 63.176351 1.376222 1.0959 0.437702
+CAGGCT 62.743227 1.72051 1.070174 0.422381
+CAGGGA 65.086731 1.237536 0.982591 0.371605
+CAGGGC 59.137246 0.772215 0.988226 0.374807
+CAGGGG 64.426498 0.901434 0.882787 0.316451
+CAGGGT 63.83487 0.968935 0.950551 0.353578
+CAGGTA 56.875994 0.781154 0.895205 0.323151
+CAGGTC 51.089488 0.879053 1.076862 0.426346
+CAGGTG 56.223211 0.821938 0.930018 0.342184
+CAGGTT 52.962204 0.953878 1.09307 0.436008
+CAGTAA 56.244837 1.141962 0.888012 0.319265
+CAGTAC 51.893797 0.613787 0.834784 0.290994
+CAGTAG 55.726703 1.140984 0.874637 0.312079
+CAGTAT 54.067239 0.933594 0.84865 0.298274
+CAGTCA 48.917892 1.072836 1.060738 0.416807
+CAGTCC 46.656699 0.748263 1.026152 0.396588
+CAGTCG 48.536087 0.986368 1.007994 0.386108
+CAGTCT 47.813282 0.898039 0.951915 0.354339
+CAGTGA 51.558028 0.694541 0.950984 0.35382
+CAGTGC 48.003488 0.769048 1.108696 0.445391
+CAGTGG 51.179614 0.774769 0.861632 0.305144
+CAGTGT 50.27605 0.608411 0.770128 0.25785
+CAGTTA 46.647529 0.683805 0.995578 0.378997
+CAGTTC 43.145185 0.758642 1.074736 0.425085
+CAGTTG 46.053058 0.597935 0.838384 0.292878
+CAGTTT 44.017733 0.601792 0.880204 0.315063
+CATAAA 63.197152 0.67435 0.66857 0.208566
+CATAAC 59.090548 0.791153 0.64173 0.196133
+CATAAG 63.910421 0.733757 0.696654 0.221845
+CATAAT 62.593703 0.646416 0.806658 0.276412
+CATACA 59.680683 0.931308 0.696137 0.221597
+CATACC 57.398289 0.672587 0.610595 0.182034
+CATACG 59.388955 0.832967 0.693748 0.220458
+CATACT 58.97643 0.687249 0.680358 0.214106
+CATAGA 62.966669 0.643163 0.709082 0.227807
+CATAGC 59.512908 0.748876 0.676011 0.212057
+CATAGG 62.619233 0.579519 0.70825 0.227406
+CATAGT 61.923056 0.638173 0.943895 0.349871
+CATATA 58.315048 0.773637 0.630674 0.191087
+CATATC 54.883602 0.671027 0.685934 0.216744
+CATATG 57.614712 0.726989 0.740635 0.24318
+CATATT 56.090222 0.779484 0.889554 0.320097
+CATCAA 62.222265 0.911088 0.857162 0.302773
+CATCAC 60.119864 0.689643 0.6757 0.211911
+CATCAG 62.90487 1.297102 0.978383 0.369221
+CATCAT 62.440918 0.93273 0.954402 0.355729
+CATCCA 58.785725 1.20454 0.87474 0.312134
+CATCCC 56.994868 0.915593 0.81288 0.279616
+CATCCG 58.905422 1.368664 0.893281 0.32211
+CATCCT 58.098212 1.048493 0.831571 0.289316
+CATCGA 61.928976 1.083411 0.897758 0.324535
+CATCGC 59.57803 0.69122 0.719534 0.232863
+CATCGG 61.251197 1.153258 0.919173 0.336216
+CATCGT 60.530749 1.029545 1.034463 0.401416
+CATCTA 57.832443 0.691289 0.66968 0.209086
+CATCTC 55.538908 0.473483 0.599966 0.177302
+CATCTG 57.126496 0.651995 0.727432 0.236707
+CATCTT 55.773557 0.5817 0.897585 0.324441
+CATGAA 61.304298 1.614102 1.062295 0.417725
+CATGAC 55.110101 1.012384 0.786605 0.266169
+CATGAG 59.791672 1.647151 0.994219 0.378221
+CATGAT 58.865216 1.446544 1.048541 0.409638
+CATGCA 56.185958 1.768822 1.240648 0.527225
+CATGCC 53.487186 1.387029 1.054165 0.412938
+CATGCG 55.701253 1.644514 1.149171 0.470002
+CATGCT 55.329544 1.40899 1.054091 0.412895
+CATGGA 58.489941 1.086649 0.941651 0.348624
+CATGGC 54.483498 0.669422 0.8716 0.310455
+CATGGG 57.400038 0.812366 0.764389 0.254973
+CATGGT 57.228437 0.787393 0.833387 0.290264
+CATGTA 50.981042 0.647231 0.775334 0.260469
+CATGTC 45.966739 0.851227 0.913862 0.333306
+CATGTG 50.165998 0.661773 0.788871 0.26732
+CATGTT 47.747708 0.971861 0.909419 0.330879
+CATTAA 54.999325 1.221188 0.910089 0.331244
+CATTAC 51.727594 0.876753 0.810777 0.278532
+CATTAG 54.912668 1.163179 0.917831 0.33548
+CATTAT 53.586729 0.917062 0.819384 0.282979
+CATTCA 48.873733 1.226458 1.070539 0.422597
+CATTCC 46.82461 1.053049 1.002543 0.382981
+CATTCG 48.881911 1.253102 1.017895 0.391811
+CATTCT 48.07643 1.035572 0.908606 0.330435
+CATTGA 50.705435 0.889849 0.998678 0.380768
+CATTGC 47.30803 0.64213 0.928705 0.34146
+CATTGG 50.621186 0.78897 0.768789 0.257178
+CATTGT 49.849468 0.837434 0.790035 0.267912
+CATTTA 45.86609 0.684416 0.923548 0.33862
+CATTTC 42.565845 0.706184 0.944232 0.350059
+CATTTG 45.36329 0.67213 0.745873 0.245765
+CATTTT 43.44808 0.525662 0.720172 0.233172
+CCAAAA 62.703394 0.878307 0.767371 0.256466
+CCAAAC 57.815156 0.696566 0.879327 0.314592
+CCAAAG 62.635436 0.659733 0.764487 0.255022
+CCAAAT 61.07231 0.722809 0.986637 0.373903
+CCAACA 57.279499 0.622798 0.819357 0.282965
+CCAACC 54.8489 0.680752 0.844845 0.29627
+CCAACG 56.940689 0.628101 0.794377 0.270124
+CCAACT 56.420212 0.581132 0.751485 0.248544
+CCAAGA 63.617795 0.626609 0.758814 0.252188
+CCAAGC 59.010286 0.733251 0.868795 0.308957
+CCAAGG 62.611729 0.688689 0.779067 0.262352
+CCAAGT 61.584779 0.704187 1.148334 0.469489
+CCAATA 57.432669 0.831078 0.811664 0.278989
+CCAATC 54.170099 1.002292 1.015173 0.390241
+CCAATG 56.829761 0.871765 0.91148 0.332004
+CCAATT 55.466044 1.178523 1.083936 0.430554
+CCACAA 66.220223 0.627805 0.749585 0.247602
+CCACAC 63.348801 0.741509 0.690795 0.219052
+CCACAG 66.67056 0.760344 0.795279 0.270584
+CCACAT 65.801215 0.6434 0.809839 0.278049
+CCACCA 62.317052 0.726591 0.671246 0.209819
+CCACCC 60.344468 0.935904 0.700027 0.223458
+CCACCG 62.095738 0.742471 0.682064 0.214912
+CCACCT 61.807362 0.74538 0.691517 0.219395
+CCACGA 65.66454 0.726848 0.719736 0.23296
+CCACGC 62.739122 0.982824 0.682315 0.21503
+CCACGG 64.78197 0.68501 0.755089 0.250334
+CCACGT 63.614283 0.653473 1.114492 0.448888
+CCACTA 61.092768 0.696738 0.633576 0.192407
+CCACTC 58.089871 0.706961 0.706616 0.22662
+CCACTG 60.254632 0.771744 0.819677 0.283131
+CCACTT 58.736202 0.878998 1.081896 0.42934
+CCAGAA 66.047214 0.946491 0.825852 0.286336
+CCAGAC 59.317561 0.670355 0.835464 0.29135
+CCAGAG 64.858659 0.899154 0.80183 0.273934
+CCAGAT 63.009147 0.708558 0.90239 0.32705
+CCAGCA 60.438385 0.887336 0.829461 0.288215
+CCAGCC 57.678816 0.713564 0.806002 0.276075
+CCAGCG 60.137961 0.796393 0.806722 0.276445
+CCAGCT 59.786038 0.756997 0.829657 0.288317
+CCAGGA 62.963713 0.835243 0.884827 0.317549
+CCAGGC 57.528382 0.860979 1.068481 0.421379
+CCAGGG 62.004425 0.726597 0.792186 0.269007
+CCAGGT 61.015594 0.767596 1.003059 0.383276
+CCAGTA 53.988011 0.995478 1.074017 0.424658
+CCAGTC 48.733731 1.319873 1.292804 0.560818
+CCAGTG 53.426753 1.055162 1.11562 0.44957
+CCAGTT 50.476572 1.409319 1.33601 0.589165
+CCATAA 60.162105 0.600145 0.63895 0.19486
+CCATAC 56.253175 0.654897 0.767683 0.256623
+CCATAG 59.969267 0.715146 0.69483 0.220974
+CCATAT 58.372754 0.549651 0.735949 0.240876
+CCATCA 54.757083 0.708381 0.831513 0.289285
+CCATCC 52.635017 0.814112 0.951342 0.35402
+CCATCG 54.66821 0.698057 0.802995 0.274531
+CCATCT 53.75703 0.566195 0.765501 0.25553
+CCATGA 54.846909 1.035629 1.029903 0.398765
+CCATGC 49.898873 0.828763 1.266189 0.543588
+CCATGG 54.68034 0.770744 0.911032 0.331759
+CCATGT 52.871065 0.683173 1.080071 0.428254
+CCATTA 49.798618 0.905519 1.207024 0.505937
+CCATTC 45.184748 0.913054 1.399493 0.631653
+CCATTG 49.035779 0.730546 1.134383 0.460959
+CCATTT 46.370186 1.042534 1.392485 0.626915
+CCCAAA 64.179687 0.977484 0.868189 0.308634
+CCCAAC 59.623465 0.915822 0.944323 0.350109
+CCCAAG 65.046699 0.724971 0.909704 0.331034
+CCCAAT 63.478508 0.752901 1.10078 0.440629
+CCCACA 63.057679 0.605471 0.709079 0.227805
+CCCACC 60.65558 0.588338 0.743946 0.244813
+CCCACG 62.683278 0.552437 0.697326 0.222166
+CCCACT 62.309632 0.542046 0.751157 0.248381
+CCCAGA 66.171361 1.074691 0.837311 0.292316
+CCCAGC 62.111451 0.993609 0.881703 0.315868
+CCCAGG 66.013134 0.786965 0.862424 0.305565
+CCCAGT 65.164559 0.969534 1.405215 0.635531
+CCCATA 62.689316 0.915447 0.76444 0.254998
+CCCATC 59.094029 1.166553 0.967357 0.362997
+CCCATG 61.98114 1.054947 0.978798 0.369456
+CCCATT 60.362037 1.306379 1.204659 0.504451
+CCCCAA 67.894503 0.722607 0.816009 0.281232
+CCCCAC 65.034974 0.844664 0.701034 0.22394
+CCCCAG 69.080025 0.672796 0.77975 0.262697
+CCCCAT 68.021789 0.623981 0.891427 0.321108
+CCCCCA 66.113096 0.631412 0.635523 0.193294
+CCCCCC 64.223388 0.601048 0.560711 0.160188
+CCCCCG 66.040932 0.6861 0.669932 0.209203
+CCCCCT 65.545835 0.564036 0.670887 0.209651
+CCCCGA 68.560741 0.682044 0.735317 0.240566
+CCCCGC 65.367916 0.961858 0.681416 0.214606
+CCCCGG 67.904075 0.631146 0.796564 0.27124
+CCCCGT 66.881899 0.705499 1.28966 0.558773
+CCCCTA 64.404594 0.936685 0.644827 0.197555
+CCCCTC 61.08819 0.818286 0.718023 0.23213
+CCCCTG 63.365338 0.862188 0.878349 0.314068
+CCCCTT 61.569558 1.19253 1.218975 0.51347
+CCCGAA 69.15998 0.895495 0.773875 0.259734
+CCCGAC 63.144139 0.776707 0.77669 0.261152
+CCCGAG 68.48496 0.887859 0.796156 0.271032
+CCCGAT 66.596532 0.786271 1.024723 0.39576
+CCCGCA 65.163542 0.879529 0.709831 0.228168
+CCCGCC 62.44694 0.552346 0.594177 0.174742
+CCCGCG 65.035786 1.074854 0.734815 0.24032
+CCCGCT 64.439476 0.6577 0.72021 0.233191
+CCCGGA 64.077374 1.045982 0.836199 0.291734
+CCCGGC 58.270139 1.095604 1.073832 0.424548
+CCCGGG 63.193216 1.070662 0.873193 0.311306
+CCCGGT 62.114366 1.066108 1.195444 0.498673
+CCCGTA 53.71824 1.396347 1.222248 0.515539
+CCCGTC 47.565328 1.554379 1.460298 0.673263
+CCCGTG 52.488291 1.504456 1.378645 0.617591
+CCCGTT 49.658856 1.682053 1.481325 0.687857
+CCCTAA 63.788809 0.584761 0.647237 0.198664
+CCCTAC 59.629308 0.571808 0.634232 0.192706
+CCCTAG 63.522991 0.578284 0.662556 0.205758
+CCCTAT 61.610333 0.538205 0.655533 0.202495
+CCCTCA 59.221881 0.52159 0.623474 0.187824
+CCCTCC 57.010807 0.554838 0.687152 0.217321
+CCCTCG 59.235313 0.605437 0.631291 0.191367
+CCCTCT 58.247512 0.496046 0.671317 0.209852
+CCCTGA 55.813407 1.187969 0.926804 0.340411
+CCCTGC 50.573254 0.888557 1.200813 0.502037
+CCCTGG 56.107644 0.682108 0.829185 0.288071
+CCCTGT 54.320498 0.796793 1.109458 0.44585
+CCCTTA 50.773007 0.822007 1.143049 0.466251
+CCCTTC 45.290736 1.005635 1.348517 0.597458
+CCCTTG 49.955304 0.937655 1.129446 0.457953
+CCCTTT 46.824389 1.004989 1.330979 0.58584
+CCGAAA 68.105307 1.044995 0.927782 0.34095
+CCGAAC 62.293938 1.049662 0.951818 0.354285
+CCGAAG 68.417663 0.867678 0.946959 0.351576
+CCGAAT 66.437678 1.099071 1.213612 0.510085
+CCGACA 60.295991 0.625109 0.673559 0.210905
+CCGACC 57.087372 0.523347 0.759047 0.252305
+CCGACG 59.869276 0.636775 0.693617 0.220395
+CCGACT 59.074295 0.591177 0.771914 0.258747
+CCGAGA 66.274993 1.133971 0.842726 0.295156
+CCGAGC 60.682317 0.935732 0.988857 0.375166
+CCGAGG 65.472195 0.961606 0.853916 0.301055
+CCGAGT 63.845688 0.971518 1.192457 0.496806
+CCGATA 58.153532 0.878691 0.894834 0.32295
+CCGATC 53.922857 1.055932 1.14017 0.46449
+CCGATG 57.450954 0.96285 0.987194 0.374219
+CCGATT 55.371939 1.380408 1.199371 0.501133
+CCGCAA 68.790724 0.772984 0.932366 0.34348
+CCGCAC 65.602559 0.833707 0.849659 0.298806
+CCGCAG 69.358266 0.702524 0.874084 0.311783
+CCGCAT 68.226185 0.780718 1.07952 0.427926
+CCGCCA 64.722602 0.595687 0.605318 0.179679
+CCGCCC 62.431692 0.788657 0.596781 0.175892
+CCGCCG 64.608108 0.574152 0.632259 0.191807
+CCGCCT 63.932203 0.54601 0.685574 0.216573
+CCGCGA 68.595993 0.709496 0.831589 0.289325
+CCGCGC 64.357361 1.020404 0.764758 0.255158
+CCGCGG 67.313177 0.629762 0.913506 0.333112
+CCGCGT 65.780261 0.751795 1.3292 0.584667
+CCGCTA 62.882644 0.961755 0.712276 0.229348
+CCGCTC 59.528533 0.858847 0.833455 0.290299
+CCGCTG 61.860395 1.023542 0.883676 0.316929
+CCGCTT 60.326729 1.105007 1.154629 0.473354
+CCGGAA 66.324023 1.446314 0.991227 0.376515
+CCGGAC 57.964166 0.740881 0.86326 0.306009
+CCGGAG 64.487809 1.700544 0.963177 0.360646
+CCGGAT 62.578565 0.967875 0.966069 0.362272
+CCGGCA 60.14895 1.750522 1.083573 0.430338
+CCGGCC 56.266276 0.959351 0.959471 0.358567
+CCGGCG 59.531998 1.485289 1.042459 0.406079
+CCGGCT 59.1433 1.461272 1.001367 0.382307
+CCGGGA 59.847177 1.061319 1.079337 0.427817
+CCGGGC 53.179568 1.029193 1.387336 0.62344
+CCGGGG 59.099543 0.894236 0.969767 0.364354
+CCGGGT 58.397279 0.8068 0.985683 0.37336
+CCGGTA 51.595408 0.869327 1.234504 0.523313
+CCGGTC 45.875306 0.893833 1.469825 0.679862
+CCGGTG 50.878062 0.803892 1.218984 0.513476
+CCGGTT 47.777124 1.0512 1.489755 0.693737
+CCGTAA 52.900064 1.161699 1.020235 0.393163
+CCGTAC 49.009244 0.684716 0.976397 0.368097
+CCGTAG 52.389094 1.14099 1.028708 0.398071
+CCGTAT 51.122562 0.8019 0.953166 0.355038
+CCGTCA 45.678124 0.967164 1.211424 0.508706
+CCGTCC 43.600661 0.766075 1.222087 0.515437
+CCGTCG 45.394611 1.042512 1.150495 0.470815
+CCGTCT 44.881186 0.893395 1.091241 0.434914
+CCGTGA 48.466058 0.773893 1.12652 0.456175
+CCGTGC 44.833569 0.848232 1.262633 0.5413
+CCGTGG 48.065513 0.883614 1.025638 0.396291
+CCGTGT 47.058783 0.688566 0.877376 0.313546
+CCGTTA 43.794875 0.725635 1.141163 0.465097
+CCGTTC 40.512417 0.824071 1.153681 0.472772
+CCGTTG 43.270515 0.692587 0.978001 0.369004
+CCGTTT 41.458344 0.646849 0.962869 0.360473
+CCTAAA 65.129487 0.661318 0.673426 0.210842
+CCTAAC 60.757584 0.805872 0.692643 0.219931
+CCTAAG 65.887184 0.572043 0.67718 0.212608
+CCTAAT 64.50466 0.569791 0.877776 0.313761
+CCTACA 61.556228 0.732786 0.662275 0.205627
+CCTACC 59.384074 0.725154 0.570982 0.16461
+CCTACG 61.329886 0.742989 0.664608 0.206714
+CCTACT 61.077109 0.641145 0.620643 0.186546
+CCTAGA 65.279581 1.344778 0.770658 0.258116
+CCTAGC 60.70862 0.922903 0.7479 0.246768
+CCTAGG 64.463928 0.635993 0.823475 0.285101
+CCTAGT 63.889894 0.659908 1.057628 0.414975
+CCTATA 59.885707 0.658793 0.634501 0.192829
+CCTATC 56.167026 0.831712 0.812331 0.279333
+CCTATG 59.319619 0.742765 0.783597 0.264644
+CCTATT 57.575873 0.821398 0.927601 0.340851
+CCTCAA 64.596971 0.74498 0.763362 0.254459
+CCTCAC 62.199345 0.506202 0.595159 0.175175
+CCTCAG 65.579306 0.75947 0.888317 0.319429
+CCTCAT 64.722989 0.800496 0.841128 0.294317
+CCTCCA 61.615873 0.900406 0.737966 0.241867
+CCTCCC 59.541982 0.65627 0.618247 0.185467
+CCTCCG 61.370198 1.022827 0.727025 0.236508
+CCTCCT 60.84028 0.959522 0.72643 0.236218
+CCTCGA 64.577098 0.842019 0.752776 0.249185
+CCTCGC 61.821412 0.553195 0.618469 0.185567
+CCTCGG 64.09607 0.817658 0.813746 0.280063
+CCTCGT 62.937168 0.800503 1.013367 0.3892
+CCTCTA 60.214311 0.52386 0.58927 0.172582
+CCTCTC 57.337718 0.890004 0.615728 0.184334
+CCTCTG 59.517964 0.515788 0.724368 0.235213
+CCTCTT 58.029888 0.943034 0.97263 0.365969
+CCTGAA 60.51531 1.450803 0.993492 0.377806
+CCTGAC 53.748729 0.729829 0.792607 0.269221
+CCTGAG 59.031835 1.349493 0.916723 0.334873
+CCTGAT 57.746434 1.453315 0.959792 0.358747
+CCTGCA 55.330786 1.56621 1.139775 0.464249
+CCTGCC 52.530507 1.205346 0.979471 0.369836
+CCTGCG 54.800703 1.436621 1.077746 0.426871
+CCTGCT 54.421595 1.290838 1.040004 0.404646
+CCTGGA 58.384013 0.899322 0.858632 0.303552
+CCTGGC 54.021624 0.599724 0.84179 0.294665
+CCTGGG 57.446997 0.834275 0.752207 0.248902
+CCTGGT 57.013013 0.709367 0.812745 0.279547
+CCTGTA 50.835798 0.75894 0.822796 0.284748
+CCTGTC 45.761617 0.934907 1.030279 0.398983
+CCTGTG 49.899125 0.725832 0.850637 0.299322
+CCTGTT 47.574597 0.926656 0.970865 0.364973
+CCTTAA 55.137482 1.179581 0.87595 0.312782
+CCTTAC 51.769444 0.834286 0.81019 0.278229
+CCTTAG 54.766311 1.087606 0.890112 0.320398
+CCTTAT 53.667156 0.994878 0.820207 0.283405
+CCTTCA 48.553244 1.144308 1.093989 0.436558
+CCTTCC 46.294358 1.051171 1.053732 0.412684
+CCTTCG 48.310259 1.18161 1.013073 0.38903
+CCTTCT 47.623819 1.228698 0.960942 0.359392
+CCTTGA 50.746142 0.906514 0.951798 0.354274
+CCTTGC 47.24583 0.609714 0.935556 0.345245
+CCTTGG 50.68826 1.174166 0.804115 0.275106
+CCTTGT 49.469542 0.757782 0.739052 0.242401
+CCTTTA 45.580536 0.563362 0.87691 0.313296
+CCTTTC 42.370864 0.67702 0.939043 0.347177
+CCTTTG 45.101229 0.599337 0.725825 0.235923
+CCTTTT 43.337685 0.528775 0.732501 0.239186
+CGAAAA 63.638224 0.719342 0.803408 0.274743
+CGAAAC 59.31773 0.985863 1.045432 0.407818
+CGAAAG 63.587377 0.741016 0.815225 0.280827
+CGAAAT 62.439715 0.920244 1.110163 0.446275
+CGAACA 55.952728 0.837316 0.962108 0.360046
+CGAACC 53.349573 0.681666 1.017065 0.391332
+CGAACG 55.636671 0.819042 0.919959 0.336647
+CGAACT 54.972276 0.59933 0.876421 0.313034
+CGAAGA 63.085824 0.822908 0.826794 0.286826
+CGAAGC 59.105791 1.00383 1.042633 0.406181
+CGAAGG 62.443312 0.857306 0.875137 0.312347
+CGAAGT 61.321136 0.931352 1.213418 0.509962
+CGAATA 56.288997 0.889851 1.040374 0.404862
+CGAATC 53.232396 1.107735 1.275107 0.549341
+CGAATG 55.747401 0.932062 1.223382 0.516256
+CGAATT 54.781182 1.319586 1.293321 0.561154
+CGACAA 62.777576 0.649425 0.657467 0.203392
+CGACAC 60.631636 0.787479 0.628644 0.190165
+CGACAG 62.794154 0.768379 0.661549 0.205289
+CGACAT 62.531823 0.620523 0.665749 0.207247
+CGACCA 58.12451 1.263075 0.731976 0.238929
+CGACCC 55.856481 0.579794 0.732505 0.239188
+CGACCG 57.520385 0.846543 0.706873 0.226743
+CGACCT 57.61982 1.25446 0.666178 0.207447
+CGACGA 61.702567 0.785568 0.68004 0.213956
+CGACGC 58.992189 0.550692 0.652521 0.201101
+CGACGG 60.643012 0.870327 0.681628 0.214706
+CGACGT 59.815255 0.588301 0.808163 0.277186
+CGACTA 57.709335 0.506145 0.606308 0.18012
+CGACTC 55.432297 0.618052 0.715308 0.230814
+CGACTG 56.944952 0.526188 0.664612 0.206717
+CGACTT 55.96607 0.676337 0.972142 0.365694
+CGAGAA 66.526883 1.018821 0.865149 0.307014
+CGAGAC 60.691376 0.778665 0.859146 0.303825
+CGAGAG 65.799478 1.486503 0.870067 0.309636
+CGAGAT 63.943728 0.810131 0.86879 0.308955
+CGAGCA 59.69233 1.046254 0.867314 0.308168
+CGAGCC 56.995195 0.687088 0.841912 0.294729
+CGAGCG 59.120116 0.846298 0.831505 0.289281
+CGAGCT 58.700602 0.704037 0.780326 0.262989
+CGAGGA 63.565576 0.903433 0.845986 0.296871
+CGAGGC 59.022145 0.712458 1.014532 0.389872
+CGAGGG 62.391483 0.70045 0.76037 0.252965
+CGAGGT 61.880445 0.750778 0.94091 0.348213
+CGAGTA 55.765428 0.751409 1.011946 0.388382
+CGAGTC 51.078724 1.013058 1.227771 0.519038
+CGAGTG 55.185175 1.071922 1.067504 0.420801
+CGAGTT 52.58582 1.16754 1.290903 0.559581
+CGATAA 56.830492 0.708775 0.698024 0.222499
+CGATAC 53.604965 0.680235 0.816836 0.28166
+CGATAG 56.655684 0.736135 0.705101 0.225891
+CGATAT 55.39178 0.622296 0.729765 0.237847
+CGATCA 50.709142 0.665445 0.90868 0.330475
+CGATCC 48.864464 0.775113 1.014202 0.389681
+CGATCG 50.61864 0.657573 0.885899 0.318126
+CGATCT 49.992573 0.659294 0.822673 0.284685
+CGATGA 53.233169 0.763336 0.964977 0.361658
+CGATGC 49.377901 0.798869 1.181119 0.489737
+CGATGG 52.852796 0.731572 0.857632 0.303022
+CGATGT 51.597117 0.685852 0.905907 0.328964
+CGATTA 48.416499 0.787464 1.085099 0.431248
+CGATTC 44.734479 0.844693 1.231805 0.521597
+CGATTG 47.772435 0.699335 0.96232 0.360165
+CGATTT 45.712197 0.780923 1.16687 0.480901
+CGCAAA 63.919941 0.961781 0.85486 0.301554
+CGCAAC 59.761721 0.960916 1.014593 0.389906
+CGCAAG 64.45672 0.648113 0.848392 0.298138
+CGCAAT 63.248265 0.954635 1.090856 0.434684
+CGCACA 61.597892 0.62334 0.733849 0.239846
+CGCACC 59.381305 0.625626 0.782934 0.264308
+CGCACG 61.304891 0.578172 0.734512 0.240171
+CGCACT 60.969984 0.619137 0.782621 0.26415
+CGCAGA 65.408593 0.817343 0.779522 0.262582
+CGCAGC 61.664138 0.995649 0.918597 0.3359
+CGCAGG 64.995347 0.759953 0.851644 0.299854
+CGCAGT 64.253139 0.945882 1.341118 0.592548
+CGCATA 61.589152 0.855742 0.823105 0.284909
+CGCATC 58.122219 1.235565 1.053826 0.41274
+CGCATG 60.86497 0.88906 0.925393 0.339635
+CGCATT 59.55913 1.296453 1.232133 0.521806
+CGCCAA 65.927305 0.590471 0.689024 0.21821
+CGCCAC 63.332157 0.6732 0.620491 0.186477
+CGCCAG 66.603597 0.608067 0.679277 0.213596
+CGCCAT 65.915781 0.553869 0.717788 0.232016
+CGCCCA 63.184539 0.681717 0.621923 0.187123
+CGCCCC 61.401565 0.530851 0.590095 0.172944
+CGCCCG 63.02608 0.669636 0.602774 0.178548
+CGCCCT 62.687333 0.665196 0.673656 0.21095
+CGCCGA 65.97376 0.606958 0.631193 0.191322
+CGCCGC 63.116785 0.6299 0.62873 0.190204
+CGCCGG 65.254997 0.66632 0.683762 0.215715
+CGCCGT 64.397532 0.688446 1.024668 0.395729
+CGCCTA 62.171034 0.591156 0.596716 0.175863
+CGCCTC 59.364981 0.646659 0.68112 0.214466
+CGCCTG 61.34324 0.726383 0.843784 0.295712
+CGCCTT 59.940667 0.87039 1.12704 0.456491
+CGCGAA 67.588763 0.799851 0.777802 0.261714
+CGCGAC 62.352383 0.668493 0.807816 0.277007
+CGCGAG 67.108123 0.741386 0.757494 0.251531
+CGCGAT 65.397571 0.720154 1.026298 0.396673
+CGCGCA 62.877002 0.741024 0.707232 0.226916
+CGCGCC 60.615448 0.618163 0.667611 0.208117
+CGCGCG 62.635612 0.793347 0.688003 0.217725
+CGCGCT 62.547103 0.817557 0.74502 0.245343
+CGCGGA 63.443006 0.813276 0.806262 0.276208
+CGCGGC 58.323227 0.982047 1.029266 0.398395
+CGCGGG 62.562099 0.786021 0.852858 0.300495
+CGCGGT 61.609028 1.015861 1.174992 0.485931
+CGCGTA 54.218902 1.426277 1.165017 0.479756
+CGCGTC 48.813662 1.448459 1.445731 0.663214
+CGCGTG 53.288127 1.269639 1.220233 0.514265
+CGCGTT 50.698577 1.655327 1.415847 0.642757
+CGCTAA 61.336013 0.665569 0.639547 0.195133
+CGCTAC 57.734592 0.583877 0.714624 0.230483
+CGCTAG 61.363361 0.772424 0.662974 0.205952
+CGCTAT 59.770974 0.520931 0.692937 0.220071
+CGCTCA 56.471532 0.639334 0.733645 0.239746
+CGCTCC 54.505598 0.767496 0.881194 0.315595
+CGCTCG 56.426101 0.662197 0.716444 0.231364
+CGCTCT 55.553422 0.587461 0.694696 0.22091
+CGCTGA 55.05524 1.052635 0.967687 0.363183
+CGCTGC 50.293495 0.87811 1.251229 0.533983
+CGCTGG 55.186745 0.676793 0.877982 0.313871
+CGCTGT 53.515184 0.715679 1.090165 0.434271
+CGCTTA 50.441802 0.860615 1.144632 0.46722
+CGCTTC 45.504588 0.972508 1.368514 0.610797
+CGCTTG 49.742036 0.732047 1.152499 0.472045
+CGCTTT 46.953891 1.098751 1.362068 0.606486
+CGGAAA 71.070973 1.01937 1.253884 0.535684
+CGGAAC 65.396217 0.97739 1.130544 0.458621
+CGGAAG 70.97876 0.999432 1.251855 0.534384
+CGGAAT 69.302175 1.027071 1.462432 0.674739
+CGGACA 59.895882 0.792703 0.740952 0.243337
+CGGACC 56.644886 0.639899 0.756625 0.251098
+CGGACG 59.33028 0.823758 0.76352 0.254538
+CGGACT 59.019121 0.734445 0.868213 0.308647
+CGGAGA 69.073939 0.993412 1.082603 0.42976
+CGGAGC 63.570324 0.970019 1.007594 0.385879
+CGGAGG 68.075606 1.026127 1.165414 0.480002
+CGGAGT 66.668678 0.988923 1.43736 0.657462
+CGGATA 59.802316 0.845425 0.91925 0.336258
+CGGATC 56.000293 1.098581 1.097595 0.438718
+CGGATG 59.249417 1.043766 1.001811 0.382562
+CGGATT 57.587548 1.152756 1.227756 0.519028
+CGGCAA 69.09412 0.920355 1.045203 0.407684
+CGGCAC 66.414806 0.743162 0.962787 0.360427
+CGGCAG 69.331582 0.924221 1.019386 0.392673
+CGGCAT 68.375707 0.951729 1.168588 0.481964
+CGGCCA 63.38483 0.782422 0.763428 0.254492
+CGGCCC 61.438784 0.562737 0.668692 0.208623
+CGGCCG 63.100111 0.783011 0.76215 0.253853
+CGGCCT 62.804858 0.653888 0.76174 0.253649
+CGGCGA 68.596572 0.891901 0.944351 0.350125
+CGGCGC 65.07994 0.68325 0.875105 0.31233
+CGGCGG 67.161392 0.895146 1.033432 0.400817
+CGGCGT 65.662784 0.867077 1.301388 0.566412
+CGGCTA 63.632977 0.608809 0.860098 0.30433
+CGGCTC 60.92913 0.84651 1.021067 0.393644
+CGGCTG 62.675511 0.687765 1.072283 0.42363
+CGGCTT 61.838923 0.875618 1.344062 0.594499
+CGGGAA 70.041321 1.872499 1.38473 0.621685
+CGGGAC 62.102796 1.349214 0.976838 0.368346
+CGGGAG 68.311641 1.835055 1.328558 0.584243
+CGGGAT 66.567938 1.395683 1.274743 0.549106
+CGGGCA 61.55607 1.764352 1.27334 0.5482
+CGGGCC 58.15889 1.17964 1.070744 0.422718
+CGGGCG 60.898588 1.656314 1.278699 0.551665
+CGGGCT 60.268627 1.353033 1.166633 0.480755
+CGGGGA 65.399218 1.281181 1.119066 0.451654
+CGGGGC 60.685405 1.660082 0.952184 0.35449
+CGGGGG 64.34891 1.13461 1.047407 0.408974
+CGGGGT 63.852797 1.139677 1.082672 0.429801
+CGGGTA 57.805422 0.847344 0.901075 0.326335
+CGGGTC 52.893436 0.853722 1.030179 0.398926
+CGGGTG 57.289487 0.801375 0.95015 0.353355
+CGGGTT 54.679104 0.951637 1.095961 0.437739
+CGGTAA 55.806149 1.134498 0.976753 0.368298
+CGGTAC 52.060952 1.027352 0.960935 0.359388
+CGGTAG 55.244773 1.195112 0.951084 0.353876
+CGGTAT 53.897628 0.89671 0.890552 0.320636
+CGGTCA 47.967886 1.109584 1.162838 0.478411
+CGGTCC 45.50668 0.915834 1.138548 0.4635
+CGGTCG 47.612709 1.192048 1.101885 0.441293
+CGGTCT 46.872227 1.003118 1.015412 0.390379
+CGGTGA 52.279791 0.916348 1.017611 0.391648
+CGGTGC 48.507687 0.567449 0.91927 0.33627
+CGGTGG 51.682996 1.129707 0.940598 0.34804
+CGGTGT 50.450655 0.653589 0.891647 0.321227
+CGGTTA 46.234743 0.662075 0.97959 0.369904
+CGGTTC 42.936971 0.642835 0.938984 0.347144
+CGGTTG 45.561479 0.615586 0.839321 0.293369
+CGGTTT 43.964781 0.604191 0.840259 0.293861
+CGTAAA 61.518534 0.814167 0.852495 0.300304
+CGTAAC 58.149167 0.544812 0.663149 0.206034
+CGTAAG 62.091381 0.8719 0.955655 0.35643
+CGTAAT 61.021441 0.774113 0.864469 0.306652
+CGTACA 57.398343 1.257559 1.031026 0.399418
+CGTACC 55.327752 0.821273 0.8262 0.286517
+CGTACG 57.138011 1.115898 0.954511 0.35579
+CGTACT 56.77843 0.905119 0.851076 0.299554
+CGTAGA 61.109544 0.798734 0.934038 0.344405
+CGTAGC 58.212197 0.520101 0.697403 0.222202
+CGTAGG 60.75629 0.901869 0.909442 0.330891
+CGTAGT 60.136983 0.868064 0.97429 0.366906
+CGTATA 56.903214 0.607238 0.669445 0.208975
+CGTATC 54.267176 0.604135 0.760345 0.252952
+CGTATG 56.369297 0.678144 0.755845 0.25071
+CGTATT 55.17124 0.694775 0.937552 0.34635
+CGTCAA 59.432132 1.061488 1.251287 0.53402
+CGTCAC 57.527079 0.943826 1.027648 0.397456
+CGTCAG 59.489123 1.317998 1.363422 0.607391
+CGTCAT 59.446015 1.358431 1.272135 0.547422
+CGTCCA 55.396289 1.478417 1.277843 0.551111
+CGTCCC 53.672351 1.290811 1.197494 0.499957
+CGTCCG 55.176004 1.337206 1.304373 0.568363
+CGTCCT 54.579464 1.192271 1.202893 0.503342
+CGTCGA 58.609439 1.28673 1.337827 0.590368
+CGTCGC 56.812783 0.956116 1.099334 0.439761
+CGTCGG 57.844158 1.338567 1.303799 0.567987
+CGTCGT 57.445969 1.125847 1.312468 0.573661
+CGTCTA 54.993873 0.886535 1.007992 0.386108
+CGTCTC 53.198657 0.696183 0.842583 0.295081
+CGTCTG 54.399935 0.902367 0.98274 0.371689
+CGTCTT 53.422566 0.857004 0.961336 0.359613
+CGTGAA 58.447715 1.771766 1.184253 0.491688
+CGTGAC 53.120951 0.930994 0.828207 0.287562
+CGTGAG 57.159387 1.453013 1.080845 0.428714
+CGTGAT 56.080573 1.687867 1.029811 0.398712
+CGTGCA 53.14017 1.69606 1.233469 0.522655
+CGTGCC 50.952868 1.335296 1.059733 0.416215
+CGTGCG 52.924993 1.716666 1.161567 0.477627
+CGTGCT 52.604633 1.46035 1.05427 0.413
+CGTGGA 56.426264 1.348993 1.16225 0.478049
+CGTGGC 53.143985 0.788994 0.953861 0.355427
+CGTGGG 55.578027 1.108897 1.031155 0.399493
+CGTGGT 55.403004 1.048204 0.969045 0.363947
+CGTGTA 50.381622 0.642419 0.798229 0.272091
+CGTGTC 46.343816 0.824511 0.778349 0.26199
+CGTGTG 49.799481 0.528634 0.765963 0.255761
+CGTGTT 48.083917 0.839174 0.817933 0.282228
+CGTTAA 52.782293 1.427535 1.050437 0.41075
+CGTTAC 49.661096 1.05181 0.90395 0.327898
+CGTTAG 52.419589 1.558658 1.086333 0.431984
+CGTTAT 51.325444 1.2112 0.903887 0.327864
+CGTTCA 46.482886 1.291127 1.122486 0.453727
+CGTTCC 44.582535 0.945033 1.05583 0.413917
+CGTTCG 46.268954 1.294439 1.062323 0.417742
+CGTTCT 45.667028 1.133323 0.943977 0.349917
+CGTTGA 49.004076 1.085391 1.045117 0.407633
+CGTTGC 46.162468 0.636123 0.969426 0.364162
+CGTTGG 48.740836 0.999523 0.908769 0.330524
+CGTTGT 47.966114 0.906618 0.819378 0.282975
+CGTTTA 44.594629 0.740949 0.943801 0.349819
+CGTTTC 41.618174 0.654987 0.877273 0.313491
+CGTTTG 44.104964 0.701981 0.724988 0.235515
+CGTTTT 42.513546 0.618369 0.7149 0.230616
+CTAAAA 63.34159 0.818708 0.69213 0.219687
+CTAAAC 58.645732 0.747412 0.779871 0.262759
+CTAAAG 63.319885 0.586242 0.666364 0.207534
+CTAAAT 61.86899 0.67552 0.914247 0.333517
+CTAACA 57.464087 0.643506 0.75534 0.250459
+CTAACC 54.995842 0.659732 0.795317 0.270603
+CTAACG 57.083183 0.632382 0.71862 0.232419
+CTAACT 56.604757 0.536945 0.684882 0.216245
+CTAAGA 63.830535 0.614569 0.69838 0.222669
+CTAAGC 59.735073 0.921258 0.84127 0.294392
+CTAAGG 63.062218 0.695966 0.724619 0.235335
+CTAAGT 61.956777 0.806855 1.0687 0.421508
+CTAATA 57.561975 0.710652 0.781476 0.26357
+CTAATC 54.424701 0.975206 1.009857 0.38718
+CTAATG 57.03633 0.876815 0.885127 0.31771
+CTAATT 55.626761 1.308076 1.029106 0.398302
+CTACAA 65.530865 0.720835 0.745355 0.245509
+CTACAC 62.892747 0.541985 0.643325 0.196865
+CTACAG 65.844571 0.788739 0.764603 0.25508
+CTACAT 65.18518 0.750644 0.789871 0.267829
+CTACCA 61.190161 0.773879 0.634048 0.192622
+CTACCC 59.430333 0.70909 0.672191 0.210262
+CTACCG 60.951724 0.662994 0.611009 0.182219
+CTACCT 60.581001 0.647104 0.622263 0.187276
+CTACGA 64.830016 0.740282 0.680556 0.214199
+CTACGC 61.832657 0.698218 0.643902 0.19713
+CTACGG 64.026505 0.686579 0.715145 0.230735
+CTACGT 62.774892 0.797704 1.002711 0.383077
+CTACTA 60.507598 1.043505 0.619404 0.185987
+CTACTC 57.706654 0.638856 0.670075 0.209271
+CTACTG 59.719699 0.676094 0.744541 0.245107
+CTACTT 58.442786 0.937395 1.006018 0.384974
+CTAGAA 66.22841 0.718341 0.793754 0.269806
+CTAGAC 60.809756 1.116906 0.813453 0.279912
+CTAGAG 65.306918 1.064834 0.770336 0.257954
+CTAGAT 63.653852 1.256743 0.96865 0.363725
+CTAGCA 60.440368 0.832088 0.736643 0.241217
+CTAGCC 57.981991 0.597911 0.747736 0.246686
+CTAGCG 60.201739 0.977969 0.766765 0.256163
+CTAGCT 60.246412 1.104872 0.903021 0.327393
+CTAGGA 63.625042 0.818035 0.689945 0.218647
+CTAGGC 58.341543 0.71859 0.999351 0.381154
+CTAGGG 62.455305 0.770587 0.780837 0.263247
+CTAGGT 61.946269 0.629045 0.900992 0.32629
+CTAGTA 55.111961 0.861418 0.919523 0.336408
+CTAGTC 50.199049 1.01991 1.082232 0.429539
+CTAGTG 54.611271 0.902327 1.001214 0.38222
+CTAGTT 52.100995 1.250322 1.125956 0.455832
+CTATAA 59.280062 0.842232 0.617496 0.185129
+CTATAC 55.658746 0.593201 0.698206 0.222586
+CTATAG 59.659538 1.324049 0.663979 0.206421
+CTATAT 57.671845 0.600846 0.622371 0.187326
+CTATCA 53.628901 0.560669 0.766136 0.255847
+CTATCC 51.593433 0.64065 0.862035 0.305358
+CTATCG 53.589581 0.624057 0.711214 0.228835
+CTATCT 52.75013 0.531884 0.660306 0.204711
+CTATGA 54.660112 0.819423 0.887815 0.319158
+CTATGC 50.132015 0.790756 1.075804 0.425718
+CTATGG 54.53757 0.761613 0.761638 0.253598
+CTATGT 52.792019 0.5562 0.891893 0.32136
+CTATTA 49.706436 0.719614 1.016786 0.391171
+CTATTC 45.392462 0.865401 1.177364 0.487404
+CTATTG 48.985573 0.648389 0.927409 0.340745
+CTATTT 46.626438 0.921573 1.143579 0.466576
+CTCAAA 63.327705 1.005951 0.792999 0.269421
+CTCAAC 58.953455 0.812098 0.83814 0.29275
+CTCAAG 63.615609 0.936118 0.823685 0.28521
+CTCAAT 62.583831 0.718292 0.940748 0.348123
+CTCACA 61.835136 0.653853 0.640517 0.195577
+CTCACC 59.491431 0.51767 0.655226 0.202353
+CTCACG 61.620379 0.617379 0.655512 0.202485
+CTCACT 61.161645 0.528027 0.665657 0.207204
+CTCAGA 65.330086 0.974233 0.813285 0.279825
+CTCAGC 61.354305 0.934579 0.84139 0.294455
+CTCAGG 64.908343 0.764316 0.827178 0.287026
+CTCAGT 64.218636 0.928043 1.200415 0.501787
+CTCATA 61.55139 0.751184 0.701111 0.223977
+CTCATC 58.527491 1.052416 0.868758 0.308937
+CTCATG 60.990706 1.034167 0.882165 0.316117
+CTCATT 59.745549 1.187821 1.095789 0.437636
+CTCCAA 66.113169 0.749535 0.826624 0.286738
+CTCCAC 63.515974 0.629883 0.70585 0.226251
+CTCCAG 67.045565 0.776867 0.849234 0.298582
+CTCCAT 66.110282 0.691328 0.828396 0.28766
+CTCCCA 63.718104 1.040951 0.74083 0.243277
+CTCCCC 62.013797 0.589925 0.625439 0.188712
+CTCCCG 63.617089 0.925139 0.719854 0.233018
+CTCCCT 63.334566 0.804263 0.742565 0.244132
+CTCCGA 66.555366 0.749623 0.803552 0.274817
+CTCCGC 63.46307 0.680264 0.687533 0.217502
+CTCCGG 65.852103 0.718085 0.801782 0.273909
+CTCCGT 64.821884 0.86999 1.173788 0.485185
+CTCCTA 62.73408 0.544144 0.64655 0.198347
+CTCCTC 60.02733 0.973023 0.676384 0.212233
+CTCCTG 61.809014 0.785469 0.867275 0.308147
+CTCCTT 60.701616 0.892923 1.024699 0.395747
+CTCGAA 67.4688 0.929552 0.833852 0.290507
+CTCGAC 62.25667 0.633025 0.687338 0.217409
+CTCGAG 67.140034 0.757031 0.753479 0.249534
+CTCGAT 65.395233 0.733558 0.898128 0.324736
+CTCGCA 63.644742 0.893516 0.697885 0.222432
+CTCGCC 61.191254 0.683063 0.591319 0.173483
+CTCGCG 63.399159 0.873501 0.691215 0.219251
+CTCGCT 63.239711 0.824001 0.764678 0.255118
+CTCGGA 63.558915 0.849969 0.800587 0.273297
+CTCGGC 58.088002 0.939508 0.961848 0.3599
+CTCGGG 62.589246 0.925515 0.836693 0.291992
+CTCGGT 61.546748 0.848024 1.111075 0.446825
+CTCGTA 54.108248 1.315795 1.003843 0.383726
+CTCGTC 48.286935 1.566553 1.343266 0.593972
+CTCGTG 53.169025 1.477713 1.110938 0.446742
+CTCGTT 50.349982 1.556318 1.31052 0.572385
+CTCTAA 62.008826 0.648396 0.633983 0.192592
+CTCTAC 58.306378 0.550742 0.580063 0.168553
+CTCTAG 62.189803 0.718591 0.65311 0.201373
+CTCTAT 60.433171 0.558561 0.628556 0.190124
+CTCTCA 57.720975 0.635178 0.614795 0.183915
+CTCTCC 55.532254 0.499658 0.6438 0.197083
+CTCTCG 57.711727 0.700128 0.637498 0.194196
+CTCTCT 56.829843 0.651235 0.618725 0.185682
+CTCTGA 55.360285 0.951289 0.795924 0.270913
+CTCTGC 50.243836 0.789513 0.969428 0.364163
+CTCTGG 55.477289 0.582624 0.685251 0.21642
+CTCTGT 53.701129 0.656743 0.892131 0.321489
+CTCTTA 50.444566 0.693471 0.850093 0.299035
+CTCTTC 45.221922 0.87661 1.110089 0.44623
+CTCTTG 49.681209 0.706517 0.807669 0.276932
+CTCTTT 46.677155 1.046156 1.03412 0.401217
+CTGAAA 68.092063 0.940167 1.071661 0.423262
+CTGAAC 62.874777 0.831572 1.067342 0.420706
+CTGAAG 68.158158 1.014338 1.095659 0.437558
+CTGAAT 66.578052 0.908505 1.329338 0.584757
+CTGACA 58.983781 0.862405 0.789507 0.267643
+CTGACC 56.375466 0.550747 0.672848 0.210571
+CTGACG 58.531692 0.798447 0.729992 0.237958
+CTGACT 58.209069 0.63762 0.724302 0.235181
+CTGAGA 66.243726 0.98777 0.967052 0.362825
+CTGAGC 61.158018 0.842178 1.004116 0.383882
+CTGAGG 65.438411 0.893429 0.99645 0.379495
+CTGAGT 63.859962 0.982434 1.300648 0.565929
+CTGATA 58.347156 0.822716 0.933381 0.344042
+CTGATC 54.24977 1.002869 0.929045 0.341647
+CTGATG 57.679547 0.904822 1.001846 0.382581
+CTGATT 56.065685 1.233623 1.061554 0.417288
+CTGCAA 67.829707 0.910654 1.141462 0.46528
+CTGCAC 64.873407 0.749519 0.927982 0.341061
+CTGCAG 68.12089 0.990258 1.246053 0.530673
+CTGCAT 67.030784 1.081648 1.236625 0.524662
+CTGCCA 62.970403 1.07056 1.036439 0.402567
+CTGCCC 60.926933 0.812051 0.824419 0.285591
+CTGCCG 62.645715 1.12887 1.037809 0.403366
+CTGCCT 62.345855 0.853149 0.926929 0.340481
+CTGCGA 67.351463 1.062891 1.130556 0.458628
+CTGCGC 63.623085 0.699272 0.840464 0.293969
+CTGCGG 66.026501 0.997066 1.150158 0.470608
+CTGCGT 64.425576 1.062103 1.381412 0.619452
+CTGCTA 62.251406 0.783257 0.864886 0.306874
+CTGCTC 59.526904 0.715704 0.924659 0.339231
+CTGCTG 61.249138 0.879209 1.065199 0.419439
+CTGCTT 60.182544 0.899416 1.29012 0.559072
+CTGGAA 66.878417 1.859341 1.263397 0.541791
+CTGGAC 59.339204 1.036574 0.793445 0.269649
+CTGGAG 65.920243 1.754518 1.251702 0.534286
+CTGGAT 63.915661 1.187758 1.151952 0.471709
+CTGGCA 60.554585 1.637285 1.05518 0.413535
+CTGGCC 57.403836 1.075257 0.837144 0.292229
+CTGGCG 60.074928 1.448325 1.012766 0.388854
+CTGGCT 59.581564 1.228302 0.962245 0.360123
+CTGGGA 61.387261 1.07162 1.056489 0.414305
+CTGGGC 55.092751 0.727634 1.005116 0.384456
+CTGGGG 60.61338 1.009964 0.939045 0.347178
+CTGGGT 60.003918 0.863887 0.961259 0.35957
+CTGGTA 53.642223 0.758147 0.855839 0.302072
+CTGGTC 48.182244 0.805194 1.006059 0.384997
+CTGGTG 52.95025 0.668213 0.865475 0.307188
+CTGGTT 50.126883 0.898016 1.008127 0.386185
+CTGTAA 54.46912 1.078808 0.831152 0.289097
+CTGTAC 50.34575 0.624308 0.813596 0.279986
+CTGTAG 53.918188 1.103207 0.822681 0.284688
+CTGTAT 52.588178 0.914511 0.783068 0.264376
+CTGTCA 47.015515 1.039504 1.027343 0.397279
+CTGTCC 44.674805 0.803315 0.945368 0.35069
+CTGTCG 46.736597 1.031907 0.984075 0.372447
+CTGTCT 45.94648 0.869486 0.914034 0.3334
+CTGTGA 50.22573 0.944675 0.934034 0.344403
+CTGTGC 46.320665 0.670533 0.961856 0.359905
+CTGTGG 49.345361 0.84668 0.809926 0.278093
+CTGTGT 48.428187 0.586532 0.724088 0.235077
+CTGTTA 44.988767 0.649066 0.936082 0.345536
+CTGTTC 41.655397 0.707374 0.963738 0.360962
+CTGTTG 44.401127 0.587312 0.77079 0.258182
+CTGTTT 42.632756 0.600028 0.798706 0.272335
+CTTAAA 62.9979 0.78792 0.803313 0.274694
+CTTAAC 59.343231 0.595556 0.719567 0.232879
+CTTAAG 63.7522 0.928779 0.875372 0.312472
+CTTAAT 62.269775 0.856903 0.933374 0.344038
+CTTACA 59.421014 1.165602 0.966875 0.362725
+CTTACC 57.389854 0.708311 0.759831 0.252696
+CTTACG 59.202704 1.017228 0.936653 0.345852
+CTTACT 58.844891 0.986126 0.866221 0.307585
+CTTAGA 62.946658 0.902072 0.899602 0.325535
+CTTAGC 59.501028 0.619067 0.789285 0.26753
+CTTAGG 62.606007 0.850473 0.859956 0.304255
+CTTAGT 61.670134 0.926856 0.994893 0.378605
+CTTATA 58.430976 0.531677 0.667958 0.208279
+CTTATC 55.607401 0.810005 0.846026 0.296892
+CTTATG 57.928818 0.625062 0.783347 0.264517
+CTTATT 56.686305 0.681236 1.007503 0.385826
+CTTCAA 61.908309 1.124992 1.182378 0.49052
+CTTCAC 59.589846 0.872527 0.93772 0.346443
+CTTCAG 62.255635 1.472262 1.397152 0.630069
+CTTCAT 61.875968 1.085742 1.227321 0.518752
+CTTCCA 58.137629 1.464638 1.305645 0.569194
+CTTCCC 56.500265 1.195234 1.162323 0.478093
+CTTCCG 58.061466 1.439758 1.294511 0.561928
+CTTCCT 57.409664 1.230202 1.221232 0.514896
+CTTCGA 61.429841 1.388982 1.360817 0.605651
+CTTCGC 59.037869 0.87641 0.995668 0.379048
+CTTCGG 60.807764 1.297986 1.313166 0.574119
+CTTCGT 59.861558 1.149371 1.322117 0.579999
+CTTCTA 57.290344 0.970262 0.948812 0.352608
+CTTCTC 55.329182 0.564175 0.718475 0.232349
+CTTCTG 56.612534 0.967896 1.021254 0.393752
+CTTCTT 55.33191 0.907338 1.070741 0.422717
+CTTGAA 59.793638 1.584776 1.159445 0.476319
+CTTGAC 54.292188 0.786385 0.73912 0.242435
+CTTGAG 58.577542 1.520721 1.051619 0.411444
+CTTGAT 57.55494 1.409255 1.023731 0.395186
+CTTGCA 55.288379 1.666305 1.096038 0.437785
+CTTGCC 52.735163 1.267582 0.934903 0.344884
+CTTGCG 54.694519 1.614887 1.069526 0.421997
+CTTGCT 54.367761 1.502292 0.999825 0.381425
+CTTGGA 57.746717 1.155789 1.143089 0.466275
+CTTGGC 54.079399 0.677095 0.904516 0.328206
+CTTGGG 56.848181 0.971721 1.005693 0.384787
+CTTGGT 56.545797 0.911541 0.944965 0.350466
+CTTGTA 51.097181 0.726246 0.716415 0.23135
+CTTGTC 46.366869 0.750932 0.828583 0.287758
+CTTGTG 50.181125 0.931263 0.740384 0.243057
+CTTGTT 47.93052 1.018523 0.786289 0.266009
+CTTTAA 54.608962 1.370343 1.011457 0.3881
+CTTTAC 51.411102 1.033629 0.848638 0.298268
+CTTTAG 54.357687 1.384301 1.052983 0.412245
+CTTTAT 53.042407 1.150489 0.906053 0.329043
+CTTTCA 48.372367 1.336806 1.023533 0.395071
+CTTTCC 46.529618 1.033604 0.958551 0.358051
+CTTTCG 48.241427 1.246491 0.936254 0.345631
+CTTTCT 47.687739 1.14363 0.817864 0.282192
+CTTTGA 50.357963 0.850075 0.965615 0.362017
+CTTTGC 47.130921 0.612614 0.873661 0.311557
+CTTTGG 50.1998 0.857104 0.820954 0.283792
+CTTTGT 49.309878 0.701809 0.720809 0.233482
+CTTTTA 45.727788 0.734175 0.843439 0.295531
+CTTTTC 42.442049 0.536947 0.703515 0.225129
+CTTTTG 45.293228 0.646472 0.637488 0.194192
+CTTTTT 43.418827 0.585069 0.613361 0.183272
+GAAAAA 61.926668 0.709783 0.67477 0.211473
+GAAAAC 57.956196 0.864888 0.863411 0.30609
+GAAAAG 62.131112 0.678053 0.68702 0.217258
+GAAAAT 60.947104 0.714099 0.89161 0.321207
+GAAACA 55.648906 0.937995 0.961605 0.359764
+GAAACC 53.376259 0.933358 1.051326 0.411271
+GAAACG 55.309941 0.870738 0.900195 0.325858
+GAAACT 54.737357 0.752576 0.809427 0.277836
+GAAAGA 61.748273 0.741809 0.744886 0.245278
+GAAAGC 58.2202 0.752319 0.873091 0.311252
+GAAAGG 61.055189 0.70235 0.711514 0.22898
+GAAAGT 60.194203 0.776506 1.010361 0.38747
+GAAATA 55.96719 0.740315 0.857994 0.303214
+GAAATC 52.782834 0.966858 1.035085 0.401778
+GAAATG 55.364458 0.854698 0.978923 0.369526
+GAAATT 54.037952 1.199677 1.117425 0.450661
+GAACAA 61.169628 1.008168 0.79281 0.269325
+GAACAC 59.114688 0.778598 0.676236 0.212163
+GAACAG 61.165943 1.224361 0.867276 0.308148
+GAACAT 61.079402 1.095765 0.840359 0.293914
+GAACCA 56.524133 1.106399 0.884462 0.317352
+GAACCC 55.230939 1.390859 0.837381 0.292353
+GAACCG 56.420525 1.250857 0.870558 0.309898
+GAACCT 55.909341 0.9655 0.791363 0.268588
+GAACGA 60.347192 1.286158 0.875211 0.312386
+GAACGC 58.035808 0.892081 0.809492 0.27787
+GAACGG 59.241542 1.10358 0.839566 0.293498
+GAACGT 58.837599 0.936379 0.877105 0.313401
+GAACTA 56.595299 0.779486 0.682399 0.21507
+GAACTC 54.43123 0.579205 0.65582 0.202628
+GAACTG 55.860189 0.854639 0.719087 0.232646
+GAACTT 54.602598 0.68328 0.84815 0.29801
+GAAGAA 65.834854 1.481356 0.931073 0.342766
+GAAGAC 60.174039 0.701949 0.762437 0.253997
+GAAGAG 64.998296 1.572406 0.917181 0.335124
+GAAGAT 63.424257 0.9765 0.892871 0.321889
+GAAGCA 59.743986 1.407424 0.964248 0.361248
+GAAGCC 56.913091 0.812117 0.83464 0.290918
+GAAGCG 59.26761 1.232547 0.936553 0.345797
+GAAGCT 58.726503 0.981762 0.871186 0.310234
+GAAGGA 62.080829 0.897877 0.89009 0.320386
+GAAGGC 58.227856 0.890073 1.057278 0.414769
+GAAGGG 61.220168 0.824723 0.805413 0.275772
+GAAGGT 60.831361 0.717598 0.869567 0.309369
+GAAGTA 54.395948 0.893583 1.028012 0.397668
+GAAGTC 49.364325 0.95239 1.200878 0.502078
+GAAGTG 53.722407 1.00007 1.028778 0.398112
+GAAGTT 51.06053 1.12136 1.208794 0.50705
+GAATAA 57.079242 1.186795 0.802653 0.274356
+GAATAC 53.746039 0.678075 0.803557 0.27482
+GAATAG 56.383707 0.917275 0.799779 0.272884
+GAATAT 55.504816 0.776977 0.744675 0.245173
+GAATCA 51.300686 0.792975 0.953432 0.355187
+GAATCC 49.417812 0.770656 0.966176 0.362332
+GAATCG 51.194183 0.768585 0.878529 0.314164
+GAATCT 50.452827 0.740316 0.779653 0.262649
+GAATGA 52.841268 0.79295 0.988238 0.374813
+GAATGC 49.409621 1.005206 1.285173 0.555859
+GAATGG 52.575605 0.74593 0.844444 0.296059
+GAATGT 51.616305 0.618044 0.85441 0.301316
+GAATTA 48.592996 0.896235 1.181721 0.490112
+GAATTC 44.810394 0.881876 1.32156 0.579633
+GAATTG 47.897949 0.715077 0.970008 0.36449
+GAATTT 45.662482 0.740878 1.193338 0.497357
+GACAAA 63.328384 0.921799 0.71353 0.229954
+GACAAC 59.395562 0.707067 0.736942 0.241364
+GACAAG 63.954572 0.701744 0.71659 0.231435
+GACAAT 62.975724 0.733432 0.816629 0.281553
+GACACA 61.618848 0.747567 0.662587 0.205772
+GACACC 59.412416 0.602636 0.617415 0.185092
+GACACG 61.830389 1.061083 0.668855 0.208699
+GACACT 60.826535 0.810551 0.661644 0.205333
+GACAGA 64.610513 0.690418 0.698157 0.222563
+GACAGC 61.412694 1.158415 0.719429 0.232812
+GACAGG 64.291839 0.638204 0.709533 0.228025
+GACAGT 63.829147 0.642205 1.093503 0.436267
+GACATA 61.285997 0.765662 0.627551 0.189669
+GACATC 58.056966 0.863918 0.781089 0.263374
+GACATG 60.561968 0.805741 0.78272 0.264199
+GACATT 59.282063 1.045283 0.994789 0.378547
+GACCAA 64.355823 1.035426 0.867524 0.30828
+GACCAC 62.001822 0.61996 0.645345 0.197793
+GACCAG 64.751795 1.18136 0.945875 0.350973
+GACCAT 64.341629 0.974671 0.948591 0.352485
+GACCCA 61.657793 1.439826 0.853712 0.300947
+GACCCC 59.76744 1.008854 0.745957 0.245806
+GACCCG 61.22768 1.285684 0.801928 0.273984
+GACCCT 60.679188 1.127524 0.787092 0.266416
+GACCGA 64.024479 1.141215 0.907442 0.3298
+GACCGC 61.829581 0.75255 0.688103 0.217772
+GACCGG 63.350996 1.177988 0.955362 0.356266
+GACCGT 62.669552 1.015563 1.110511 0.446485
+GACCTA 60.792585 0.596867 0.647123 0.198611
+GACCTC 58.224973 0.700153 0.590004 0.172904
+GACCTG 59.825912 0.65574 0.74614 0.245897
+GACCTT 58.59922 0.691607 1.014613 0.389918
+GACGAA 66.480585 1.097034 0.908126 0.330173
+GACGAC 62.074019 0.658083 0.647451 0.198762
+GACGAG 66.052048 1.092086 0.898055 0.324696
+GACGAT 64.682803 0.888799 0.874982 0.312263
+GACGCA 62.866106 1.347815 0.815791 0.28112
+GACGCC 60.540324 0.908973 0.64504 0.197652
+GACGCG 62.701099 1.276483 0.80897 0.277601
+GACGCT 62.533222 1.266532 0.870664 0.309955
+GACGGA 62.487112 0.784802 0.772782 0.259184
+GACGGC 57.929412 0.686542 0.821367 0.284007
+GACGGG 61.702856 0.786236 0.772317 0.25895
+GACGGT 61.116752 0.683414 1.044789 0.407442
+GACGTA 53.602307 1.209143 0.960341 0.359055
+GACGTC 48.16711 1.43725 1.228694 0.519623
+GACGTG 52.748623 1.308651 1.021733 0.39403
+GACGTT 50.222336 1.461572 1.160921 0.477229
+GACTAA 61.294483 0.935881 0.702885 0.224827
+GACTAC 57.974365 0.865378 0.594076 0.174697
+GACTAG 61.707208 1.272318 0.786524 0.266128
+GACTAT 59.817621 0.757452 0.684873 0.216241
+GACTCA 56.949743 1.014608 0.683237 0.215466
+GACTCC 54.643335 0.622005 0.669967 0.20922
+GACTCG 56.767649 0.791641 0.660225 0.204673
+GACTCT 56.111825 0.82975 0.655563 0.202509
+GACTGA 54.826466 0.886165 0.748954 0.247289
+GACTGC 50.500204 0.810356 0.961736 0.359838
+GACTGG 55.102855 0.594231 0.650681 0.200251
+GACTGT 53.674333 0.604144 0.761175 0.253367
+GACTTA 50.518704 0.789289 0.830949 0.288991
+GACTTC 45.553992 0.865934 1.058177 0.415298
+GACTTG 49.751049 0.63566 0.823211 0.284963
+GACTTT 46.811101 0.929934 0.95278 0.354823
+GAGAAA 69.749285 0.945043 1.067798 0.420975
+GAGAAC 64.689678 1.066016 0.943448 0.349623
+GAGAAG 70.052426 0.958025 1.078656 0.427412
+GAGAAT 68.626612 0.878487 1.353126 0.600524
+GAGACA 59.902823 0.8503 0.712356 0.229387
+GAGACC 57.184961 0.70676 0.781223 0.263442
+GAGACG 59.414183 0.693237 0.709639 0.228075
+GAGACT 58.856587 0.695754 0.753763 0.249675
+GAGAGA 68.031333 1.285429 0.908701 0.330487
+GAGAGC 63.080912 0.936239 0.919056 0.336152
+GAGAGG 67.015851 1.285826 0.974023 0.366755
+GAGAGT 65.993991 1.001078 1.238585 0.52591
+GAGATA 59.534989 0.87613 0.856091 0.302205
+GAGATC 55.64573 1.094238 1.089221 0.433707
+GAGATG 58.980035 0.999624 0.965244 0.361808
+GAGATT 57.302894 1.225262 1.155717 0.474024
+GAGCAA 67.191408 0.930988 0.907723 0.329953
+GAGCAC 64.65291 0.762734 0.754395 0.249989
+GAGCAG 67.402621 1.027319 0.918298 0.335736
+GAGCAT 66.61009 0.985313 0.959318 0.358481
+GAGCCA 61.640167 0.910028 0.770289 0.257931
+GAGCCC 59.776854 0.595618 0.680306 0.214082
+GAGCCG 61.244898 0.923069 0.734953 0.240388
+GAGCCT 61.188254 0.8766 0.789064 0.267418
+GAGCGA 66.402619 1.079551 0.861546 0.305099
+GAGCGC 63.225596 0.676838 0.72611 0.236062
+GAGCGG 65.192891 0.930693 0.87151 0.310407
+GAGCGT 63.955297 0.924216 1.163727 0.47896
+GAGCTA 61.716354 0.696174 0.713103 0.229748
+GAGCTC 59.009913 1.187875 0.781169 0.263415
+GAGCTG 60.822739 0.69884 0.877625 0.313679
+GAGCTT 60.084058 0.82585 1.093865 0.436484
+GAGGAA 71.355409 1.609041 1.225455 0.517569
+GAGGAC 64.572065 1.072531 0.863924 0.306363
+GAGGAG 70.214242 1.628149 1.171399 0.483704
+GAGGAT 68.442396 1.310539 1.152597 0.472106
+GAGGCA 64.200442 1.489985 1.057674 0.415002
+GAGGCC 60.843295 0.935475 0.809322 0.277782
+GAGGCG 63.709174 1.428922 1.024674 0.395732
+GAGGCT 63.353959 1.425972 1.017365 0.391506
+GAGGGA 65.937046 1.185803 0.971654 0.365418
+GAGGGC 60.146991 0.719005 0.960198 0.358975
+GAGGGG 64.857568 1.012469 0.858594 0.303532
+GAGGGT 64.615402 0.95442 0.974826 0.367209
+GAGGTA 58.0464 0.776274 0.911593 0.332066
+GAGGTC 52.736267 0.960005 1.110029 0.446195
+GAGGTG 57.433643 0.82772 1.014424 0.389809
+GAGGTT 54.508539 1.156844 1.161133 0.477359
+GAGTAA 57.907065 0.998668 0.821722 0.284191
+GAGTAC 53.959732 0.592 0.819292 0.282931
+GAGTAG 57.463778 0.968882 0.838085 0.292721
+GAGTAT 56.287454 1.600436 0.823928 0.285336
+GAGTCA 50.504714 0.782915 0.959854 0.358782
+GAGTCC 48.560716 0.704267 0.9731 0.366234
+GAGTCG 50.123871 0.909698 0.989963 0.375795
+GAGTCT 49.649604 0.679658 0.866901 0.307948
+GAGTGA 53.711009 0.720317 0.898651 0.325019
+GAGTGC 50.023409 0.742518 1.017137 0.391374
+GAGTGG 53.212716 0.743167 0.797384 0.271659
+GAGTGT 52.267528 0.583943 0.791947 0.268885
+GAGTTA 48.589894 0.738958 1.025008 0.395925
+GAGTTC 44.851608 0.727182 1.070798 0.42275
+GAGTTG 47.854795 0.664304 0.86223 0.305462
+GAGTTT 45.927284 0.775439 1.028602 0.39801
+GATAAA 62.180809 0.919741 0.739246 0.242497
+GATAAC 58.796815 0.567737 0.627897 0.189826
+GATAAG 62.661877 1.014851 0.814223 0.280309
+GATAAT 61.668981 0.804909 0.777888 0.261757
+GATACA 58.559162 1.070263 0.745389 0.245526
+GATACC 56.461384 0.795585 0.680234 0.214048
+GATACG 58.432015 1.088585 0.735143 0.240481
+GATACT 57.70642 0.986461 0.74469 0.245181
+GATAGA 61.957142 0.902157 0.816389 0.281429
+GATAGC 58.933175 0.532773 0.670712 0.209569
+GATAGG 61.581863 0.744757 0.763399 0.254478
+GATAGT 60.887429 0.835537 0.87817 0.313972
+GATATA 57.744023 0.578185 0.612351 0.18282
+GATATC 54.726599 0.797343 0.659021 0.204113
+GATATG 57.219208 0.599701 0.70605 0.226347
+GATATT 55.836242 1.119645 0.865889 0.307408
+GATCAA 60.366633 1.205782 1.013332 0.38918
+GATCAC 58.291134 1.044899 0.838878 0.293137
+GATCAG 60.547689 1.586737 1.022946 0.394731
+GATCAT 60.392286 1.40488 1.017104 0.391355
+GATCCA 56.751277 1.535011 0.971566 0.365369
+GATCCC 54.988345 1.289945 0.911975 0.332274
+GATCCG 56.487102 1.519357 0.961133 0.359499
+GATCCT 55.968315 1.199769 0.878729 0.314272
+GATCGA 59.633205 1.447928 1.018783 0.392324
+GATCGC 57.882122 1.055353 0.908132 0.330176
+GATCGG 58.934583 1.481061 1.024134 0.395419
+GATCGT 58.526627 1.251639 1.096366 0.437982
+GATCTA 56.128859 0.912015 0.790048 0.267919
+GATCTC 54.204071 0.710734 0.708859 0.2277
+GATCTG 55.425115 1.031469 0.795067 0.270476
+GATCTT 54.282232 0.77315 0.843078 0.295341
+GATGAA 60.737473 1.665953 1.067549 0.420827
+GATGAC 55.393743 0.915191 0.760652 0.253105
+GATGAG 59.34451 1.473245 0.99735 0.380009
+GATGAT 58.735535 1.485722 1.034891 0.401666
+GATGCA 55.831152 1.824828 1.220029 0.514136
+GATGCC 53.590785 1.338518 0.960133 0.358938
+GATGCG 55.594033 1.747686 1.110706 0.446602
+GATGCT 55.29499 1.503953 1.100891 0.440696
+GATGGA 57.915486 1.228168 0.939472 0.347415
+GATGGC 54.533412 0.717917 0.888441 0.319496
+GATGGG 57.097456 1.01748 0.840101 0.293778
+GATGGT 56.828029 0.841317 0.857872 0.303149
+GATGTA 51.268837 0.707125 0.763144 0.254351
+GATGTC 46.512786 0.805391 0.880679 0.315318
+GATGTG 50.467616 0.630974 0.762419 0.253988
+GATGTT 48.24786 0.818088 0.834917 0.291063
+GATTAA 55.029803 1.369583 0.921903 0.337715
+GATTAC 51.852221 0.919513 0.776956 0.261287
+GATTAG 54.542957 1.372539 0.933421 0.344064
+GATTAT 53.54338 1.080937 0.805609 0.275873
+GATTCA 49.057572 1.326914 1.033564 0.400893
+GATTCC 47.055026 1.101265 0.977463 0.3687
+GATTCG 48.928477 1.310334 1.011463 0.388103
+GATTCT 48.244402 1.152615 0.894057 0.32253
+GATTGA 50.747317 0.835897 0.963144 0.360628
+GATTGC 47.661733 0.655794 0.920868 0.337147
+GATTGG 50.724928 0.831036 0.755946 0.25076
+GATTGT 49.999901 0.74613 0.73046 0.238186
+GATTTA 46.381473 0.780925 0.9134 0.333054
+GATTTC 42.99926 0.6095 0.82843 0.287678
+GATTTG 45.834919 0.618328 0.740446 0.243088
+GATTTT 43.867113 0.470619 0.638892 0.194833
+GCAAAA 62.55216 0.827775 0.774336 0.259966
+GCAAAC 57.964823 0.800515 0.890325 0.320513
+GCAAAG 62.480094 0.65057 0.793625 0.26974
+GCAAAT 61.057664 0.690082 0.978669 0.369382
+GCAACA 57.260575 0.72589 0.855791 0.302047
+GCAACC 54.948705 0.732528 0.936923 0.346002
+GCAACG 56.904116 0.697115 0.866994 0.307997
+GCAACT 56.348003 0.596438 0.79612 0.271013
+GCAAGA 63.209908 0.65005 0.751557 0.248579
+GCAAGC 59.084909 0.759806 0.868537 0.30882
+GCAAGG 62.405742 0.677391 0.784813 0.26526
+GCAAGT 61.435744 0.718184 1.093022 0.435979
+GCAATA 57.533922 0.892337 0.848341 0.298111
+GCAATC 54.382277 1.104615 1.055815 0.413908
+GCAATG 56.925274 0.972746 0.934674 0.344757
+GCAATT 55.712506 1.34702 1.098612 0.439328
+GCACAA 65.225285 0.800815 0.750852 0.24823
+GCACAC 62.558129 0.776809 0.65741 0.203365
+GCACAG 65.640028 0.918827 0.790761 0.268281
+GCACAT 64.867177 0.768988 0.824184 0.285469
+GCACCA 61.370352 0.881679 0.713103 0.229747
+GCACCC 59.540764 0.812425 0.718044 0.23214
+GCACCG 61.199096 0.881591 0.735071 0.240445
+GCACCT 60.763305 0.923945 0.73639 0.241093
+GCACGA 64.561764 0.859468 0.736863 0.241325
+GCACGC 62.358658 1.287349 0.702166 0.224482
+GCACGG 63.771672 0.782961 0.7817 0.263684
+GCACGT 62.687486 0.789703 1.057158 0.414699
+GCACTA 60.437478 0.574343 0.64459 0.197446
+GCACTC 57.627667 0.660829 0.717146 0.231704
+GCACTG 59.626073 0.687714 0.766175 0.255867
+GCACTT 58.333859 0.792591 1.092562 0.435704
+GCAGAA 65.722134 1.245045 0.819388 0.282981
+GCAGAC 59.579962 0.808212 0.828803 0.287872
+GCAGAG 64.491205 0.882445 0.805326 0.275727
+GCAGAT 62.934772 0.738876 0.905492 0.328738
+GCAGCA 60.243063 0.891031 0.853332 0.300746
+GCAGCC 57.607008 0.726097 0.826302 0.28657
+GCAGCG 59.951302 0.841683 0.836531 0.291908
+GCAGCT 59.593135 0.749248 0.84383 0.295736
+GCAGGA 62.72715 0.766807 0.869256 0.309203
+GCAGGC 57.608487 0.821059 1.029357 0.398448
+GCAGGG 61.791458 0.712884 0.786914 0.266326
+GCAGGT 60.896722 0.787657 0.996092 0.379291
+GCAGTA 54.111834 1.055562 1.055162 0.413524
+GCAGTC 49.084973 1.490452 1.361222 0.605921
+GCAGTG 53.609683 1.098068 1.129421 0.457938
+GCAGTT 50.91419 1.4646 1.327462 0.58352
+GCATAA 59.842697 0.622988 0.673699 0.21097
+GCATAC 56.227779 0.646654 0.796012 0.270958
+GCATAG 59.735438 0.728641 0.699734 0.223317
+GCATAT 58.296758 0.621313 0.743741 0.244712
+GCATCA 54.562782 0.736659 0.85865 0.303561
+GCATCC 52.519483 0.796121 0.977038 0.368459
+GCATCG 54.550604 0.789169 0.874724 0.312126
+GCATCT 53.70312 0.626941 0.805518 0.275826
+GCATGA 54.948133 1.015988 0.991625 0.376742
+GCATGC 50.253925 0.831317 1.241447 0.527734
+GCATGG 54.744723 0.73273 0.913857 0.333304
+GCATGT 53.021136 0.735863 1.060763 0.416822
+GCATTA 49.851328 0.868003 1.157186 0.474927
+GCATTC 45.419946 1.017189 1.389698 0.625034
+GCATTG 49.201235 0.766017 1.136461 0.462226
+GCATTT 46.741821 1.109899 1.401217 0.632821
+GCCAAA 63.781085 0.985318 0.802244 0.274146
+GCCAAC 59.374228 0.844606 0.865643 0.307277
+GCCAAG 64.484288 0.672558 0.783259 0.264473
+GCCAAT 63.056555 0.782315 0.985628 0.37333
+GCCACA 62.543099 0.671756 0.679869 0.213875
+GCCACC 60.239209 0.551814 0.69174 0.219501
+GCCACG 62.250165 0.635509 0.680646 0.214242
+GCCACT 61.844788 0.591204 0.719988 0.233083
+GCCAGA 65.779461 1.129187 0.767209 0.256385
+GCCAGC 61.738417 0.888084 0.817344 0.281923
+GCCAGG 65.412188 0.82928 0.805383 0.275757
+GCCAGT 64.631829 0.90549 1.26394 0.542141
+GCCATA 62.132645 0.797724 0.720816 0.233485
+GCCATC 58.793251 1.035083 0.893733 0.322355
+GCCATG 61.560894 0.906297 0.905598 0.328795
+GCCATT 60.11048 1.12307 1.140426 0.464647
+GCCCAA 66.804333 0.72028 0.800107 0.273052
+GCCCAC 64.289536 0.596612 0.66315 0.206035
+GCCCAG 67.846797 0.788819 0.805312 0.27572
+GCCCAT 66.871141 0.723465 0.838707 0.293048
+GCCCCA 64.919615 0.831373 0.701384 0.224108
+GCCCCC 62.957011 0.635629 0.580369 0.168686
+GCCCCG 64.581161 0.821226 0.674326 0.211265
+GCCCCT 64.35502 0.741984 0.725501 0.235765
+GCCCGA 67.191799 0.7363 0.724349 0.235204
+GCCCGC 64.13352 0.674103 0.641252 0.195914
+GCCCGG 66.584084 0.750278 0.82471 0.285742
+GCCCGT 65.524373 0.723836 1.205924 0.505245
+GCCCTA 63.358112 0.694244 0.625298 0.188648
+GCCCTC 60.34523 0.715679 0.626716 0.18929
+GCCCTG 62.395096 0.890168 0.832337 0.289716
+GCCCTT 60.791248 0.926165 1.084722 0.431023
+GCCGAA 68.092469 0.926152 0.794666 0.270271
+GCCGAC 62.645912 0.619791 0.682259 0.215004
+GCCGAG 67.634533 0.769157 0.751231 0.248418
+GCCGAT 65.9436 0.812286 0.913672 0.333202
+GCCGCA 64.671636 1.035615 0.734972 0.240397
+GCCGCC 61.78184 0.585132 0.596475 0.175756
+GCCGCG 64.408469 1.162086 0.734996 0.240409
+GCCGCT 63.768724 0.896321 0.750617 0.248113
+GCCGGA 63.516498 1.102671 0.764011 0.254784
+GCCGGC 58.110841 1.03418 0.972823 0.366078
+GCCGGG 62.751751 0.93948 0.82293 0.284817
+GCCGGT 61.695092 0.897631 1.111288 0.446953
+GCCGTA 53.45466 1.495605 1.191315 0.496092
+GCCGTC 47.638454 1.716008 1.439182 0.658713
+GCCGTG 52.669485 1.422904 1.263471 0.54184
+GCCGTT 49.863187 1.799554 1.418703 0.644703
+GCCTAA 63.102541 0.826017 0.606292 0.180113
+GCCTAC 59.101059 0.563507 0.648248 0.199129
+GCCTAG 63.203109 1.35781 0.671392 0.209888
+GCCTAT 61.1819 0.531612 0.649965 0.199921
+GCCTCA 58.63756 0.742959 0.616924 0.184871
+GCCTCC 56.450007 0.559812 0.665304 0.207039
+GCCTCG 58.563182 0.642278 0.628178 0.189953
+GCCTCT 57.690561 0.608523 0.657173 0.203255
+GCCTGA 55.515453 1.085427 0.857725 0.303071
+GCCTGC 50.545382 0.855042 1.113643 0.448375
+GCCTGG 55.906178 0.656673 0.759864 0.252713
+GCCTGT 54.189355 0.817318 0.978382 0.36922
+GCCTTA 50.628857 0.788066 0.992107 0.377016
+GCCTTC 45.401473 0.942337 1.307668 0.570517
+GCCTTG 50.001576 0.799494 0.999319 0.381135
+GCCTTT 46.804649 1.062317 1.167417 0.48124
+GCGAAA 68.317098 0.970695 0.946909 0.351548
+GCGAAC 62.703291 0.974897 0.941408 0.348489
+GCGAAG 68.444629 0.987869 0.973241 0.366314
+GCGAAT 66.372624 1.425857 1.21445 0.510613
+GCGACA 60.27882 0.676788 0.724233 0.235147
+GCGACC 57.233718 0.64258 0.800144 0.27307
+GCGACG 59.768038 0.670534 0.721104 0.233625
+GCGACT 59.133343 0.60421 0.765716 0.255637
+GCGAGA 66.530006 1.121367 0.849259 0.298595
+GCGAGC 61.041226 0.905777 0.945332 0.35067
+GCGAGG 65.577664 0.947623 0.857108 0.302744
+GCGAGT 64.054228 0.991468 1.193595 0.497517
+GCGATA 58.509902 0.883714 0.874855 0.312195
+GCGATC 54.329985 1.212835 1.152884 0.472282
+GCGATG 57.900585 1.047115 0.979802 0.370024
+GCGATT 56.074308 1.316871 1.210577 0.508173
+GCGCAA 68.153244 0.83961 0.888193 0.319362
+GCGCAC 65.296528 0.741542 0.837263 0.292291
+GCGCAG 68.684935 0.846159 0.884052 0.317132
+GCGCAT 67.647064 0.852347 1.029943 0.398788
+GCGCCA 64.11643 0.720287 0.647208 0.19865
+GCGCCC 61.9562 0.738376 0.616124 0.184512
+GCGCCG 63.882923 0.7798 0.67436 0.211281
+GCGCCT 63.474093 0.656646 0.709919 0.228211
+GCGCGA 67.857873 0.85309 0.799023 0.272497
+GCGCGC 64.124634 0.824301 0.79672 0.27132
+GCGCGG 66.606415 0.817148 0.861821 0.305245
+GCGCGT 65.179273 0.799831 1.283289 0.554637
+GCGCTA 62.7234 0.806077 0.721597 0.233865
+GCGCTC 59.396528 0.863014 0.802038 0.274041
+GCGCTG 61.712528 0.810654 0.85914 0.303821
+GCGCTT 60.308256 1.004303 1.141956 0.465583
+GCGGAA 66.359373 1.341954 0.988973 0.375231
+GCGGAC 58.686747 0.784777 0.867939 0.308501
+GCGGAG 65.20416 1.835274 1.050211 0.410618
+GCGGAT 63.018145 1.009056 0.9588 0.358191
+GCGGCA 60.406634 1.748532 1.076037 0.425856
+GCGGCC 56.727038 0.905339 0.929974 0.34216
+GCGGCG 59.723809 1.535523 1.083656 0.430388
+GCGGCT 59.608258 1.693008 1.015939 0.390683
+GCGGGA 60.295958 0.950062 1.06058 0.416714
+GCGGGC 53.829495 1.043057 1.328516 0.584215
+GCGGGG 59.477632 0.862421 0.965565 0.361989
+GCGGGT 58.829768 0.814457 0.986341 0.373735
+GCGGTA 52.195313 0.847387 1.16961 0.482596
+GCGGTC 46.457359 0.924668 1.400689 0.632463
+GCGGTG 51.444799 0.789927 1.139108 0.463842
+GCGGTT 48.478745 1.112314 1.407684 0.637206
+GCGTAA 53.702309 0.992765 0.974976 0.367294
+GCGTAC 49.975895 0.690905 1.001714 0.382506
+GCGTAG 53.125527 1.087233 1.031851 0.399897
+GCGTAT 51.929034 0.727182 0.904579 0.328241
+GCGTCA 46.485436 0.932095 1.169853 0.482747
+GCGTCC 44.468617 0.776656 1.139444 0.464047
+GCGTCG 46.267611 0.862662 1.13963 0.464161
+GCGTCT 45.704668 0.761279 1.025913 0.39645
+GCGTGA 49.41412 0.804014 1.157378 0.475046
+GCGTGC 45.705414 0.85018 1.248723 0.53238
+GCGTGG 48.977944 0.812028 0.996281 0.379398
+GCGTGT 47.911174 0.672906 0.907484 0.329823
+GCGTTA 44.713535 0.844829 1.161986 0.477886
+GCGTTC 41.241025 0.837539 1.192025 0.496536
+GCGTTG 44.057997 0.702361 0.997923 0.380337
+GCGTTT 42.169548 0.647297 1.017239 0.391432
+GCTAAA 64.352837 0.733699 0.689954 0.218652
+GCTAAC 60.092185 0.713003 0.677296 0.212662
+GCTAAG 65.036293 0.696018 0.715526 0.23092
+GCTAAT 63.616489 0.669788 0.906945 0.329529
+GCTACA 60.879944 0.812944 0.732964 0.239412
+GCTACC 58.617679 0.671659 0.618863 0.185744
+GCTACG 60.688755 0.799168 0.666894 0.207782
+GCTACT 60.295836 0.817237 0.676093 0.212096
+GCTAGA 64.088245 0.827789 0.69381 0.220487
+GCTAGC 60.181772 0.648192 0.756756 0.251163
+GCTAGG 63.938488 0.67929 0.735361 0.240588
+GCTAGT 63.0082 0.587441 0.983262 0.371986
+GCTATA 59.43859 0.674455 0.642069 0.196288
+GCTATC 55.923367 0.832476 0.769441 0.257505
+GCTATG 58.880635 0.694838 0.7725 0.259042
+GCTATT 57.216661 0.827792 0.950046 0.353296
+GCTCAA 63.587356 0.945485 0.828831 0.287887
+GCTCAC 61.2472 0.613841 0.634046 0.192621
+GCTCAG 64.298317 1.205116 0.921856 0.337689
+GCTCAT 63.672886 0.873061 0.891393 0.32109
+GCTCCA 60.440203 1.121317 0.800399 0.273201
+GCTCCC 58.550658 0.846999 0.763917 0.254737
+GCTCCG 60.343 1.240368 0.83696 0.292132
+GCTCCT 59.661103 0.963023 0.792442 0.269138
+GCTCGA 63.548471 0.93292 0.854295 0.301255
+GCTCGC 60.944349 0.63175 0.65704 0.203194
+GCTCGG 62.884091 0.983531 0.917362 0.335223
+GCTCGT 61.786848 0.992978 1.033565 0.400894
+GCTCTA 59.29128 0.660384 0.641724 0.196131
+GCTCTC 56.695881 0.671391 0.626407 0.189151
+GCTCTG 58.508205 0.61054 0.732087 0.238983
+GCTCTT 57.244604 0.661584 0.949766 0.353141
+GCTGAA 60.233883 1.49423 1.002826 0.383143
+GCTGAC 53.938218 0.758344 0.800308 0.273155
+GCTGAG 58.80315 1.30303 0.96214 0.360064
+GCTGAT 57.895879 1.484923 0.997179 0.379911
+GCTGCA 55.332722 1.598262 1.134276 0.460894
+GCTGCC 52.648346 1.420152 1.005584 0.384725
+GCTGCG 54.793361 1.545716 1.100493 0.440457
+GCTGCT 54.454372 1.324761 0.996336 0.37943
+GCTGGA 58.087819 0.970602 0.918309 0.335742
+GCTGGC 53.964718 0.607014 0.846647 0.297219
+GCTGGG 57.11549 0.854998 0.768042 0.256803
+GCTGGT 56.779588 0.708221 0.807997 0.2771
+GCTGTA 50.787728 0.713589 0.811152 0.278725
+GCTGTC 45.824456 0.93737 1.014804 0.390028
+GCTGTG 49.864288 0.711922 0.838693 0.29304
+GCTGTT 47.665215 1.01663 0.960766 0.359293
+GCTTAA 55.236485 1.130525 0.891509 0.321152
+GCTTAC 51.763668 0.850092 0.801244 0.273634
+GCTTAG 54.878621 1.249502 0.944628 0.350279
+GCTTAT 53.769187 1.04185 0.80378 0.274934
+GCTTCA 48.794052 1.271433 1.119532 0.451937
+GCTTCC 46.583131 1.27076 1.089333 0.433774
+GCTTCG 48.455267 1.16825 1.030916 0.399353
+GCTTCT 47.963563 1.145216 0.942989 0.349368
+GCTTGA 50.796522 0.873467 0.945146 0.350567
+GCTTGC 47.417061 0.612056 0.95062 0.353617
+GCTTGG 50.707488 0.982729 0.825883 0.286352
+GCTTGT 49.662742 0.728428 0.763482 0.254519
+GCTTTA 45.879562 0.607852 0.933481 0.344097
+GCTTTC 42.578405 0.665488 0.949534 0.353011
+GCTTTG 45.315214 0.558653 0.721804 0.233965
+GCTTTT 43.543354 0.539194 0.717488 0.23187
+GGAAAA 64.940481 1.03602 0.976944 0.368406
+GGAAAC 61.461303 1.401613 1.208693 0.506987
+GGAAAG 64.982588 1.035188 0.997876 0.38031
+GGAAAT 64.014901 1.29268 1.293744 0.561429
+GGAACA 56.837418 1.056583 1.111119 0.446852
+GGAACC 54.262561 0.880018 1.209906 0.50775
+GGAACG 56.297284 0.927813 1.052618 0.41203
+GGAACT 56.004503 0.992609 1.1088 0.445454
+GGAAGA 64.50633 1.055641 0.950681 0.353651
+GGAAGC 61.284181 1.35072 1.215284 0.511139
+GGAAGG 63.878453 1.078971 1.038491 0.403763
+GGAAGT 63.066607 1.244096 1.487004 0.691816
+GGAATA 57.99028 1.287134 1.198784 0.500765
+GGAATC 55.157677 1.400061 1.467931 0.678549
+GGAATG 57.490851 1.263702 1.318151 0.577391
+GGAATT 56.971803 1.511779 1.538547 0.728096
+GGACAA 61.842916 0.8281 0.660081 0.204606
+GGACAC 60.309663 0.705801 0.654909 0.202206
+GGACAG 61.803107 0.984772 0.700868 0.22386
+GGACAT 61.684303 0.842225 0.722332 0.234222
+GGACCA 56.673642 0.831098 0.75445 0.250016
+GGACCC 54.938931 0.673888 0.810812 0.27855
+GGACCG 56.619436 1.112688 0.745777 0.245717
+GGACCT 56.08104 0.66334 0.684836 0.216223
+GGACGA 60.816397 0.82628 0.729285 0.237612
+GGACGC 58.387813 0.655782 0.702286 0.22454
+GGACGG 59.668089 1.002661 0.767742 0.256652
+GGACGT 59.06826 0.653862 0.820102 0.283351
+GGACTA 57.236361 0.660435 0.675917 0.212013
+GGACTC 55.158346 0.543067 0.699127 0.223027
+GGACTG 56.525293 0.618326 0.711344 0.228898
+GGACTT 55.799217 0.739926 0.992622 0.37731
+GGAGAA 67.016153 0.918241 0.86692 0.307958
+GGAGAC 62.086936 0.996677 1.007856 0.386029
+GGAGAG 66.444194 1.031343 0.876237 0.312936
+GGAGAT 65.01816 0.961104 1.066132 0.41999
+GGAGCA 60.031209 0.944904 0.88713 0.318789
+GGAGCC 57.733398 0.885042 0.931667 0.343095
+GGAGCG 59.609855 0.966354 0.859766 0.304154
+GGAGCT 59.323842 0.81941 0.849004 0.29846
+GGAGGA 64.274771 1.030505 0.913591 0.333158
+GGAGGC 60.180077 0.835834 1.038674 0.40387
+GGAGGG 63.136539 0.799397 0.872339 0.31085
+GGAGGT 62.693341 0.76254 1.085518 0.431497
+GGAGTA 56.880992 0.776548 1.053432 0.412508
+GGAGTC 52.870414 1.234762 1.453791 0.668768
+GGAGTG 56.335417 1.032094 1.158004 0.475431
+GGAGTT 54.447577 1.414765 1.392092 0.626649
+GGATAA 57.229657 0.831832 0.755913 0.250744
+GGATAC 54.242749 0.732485 0.86531 0.3071
+GGATAG 57.04426 0.884081 0.754415 0.249999
+GGATAT 55.919952 0.747854 0.806523 0.276343
+GGATCA 51.480366 1.055718 1.08751 0.432686
+GGATCC 49.517323 0.914092 1.070281 0.422444
+GGATCG 51.239974 0.989782 1.037867 0.403399
+GGATCT 50.547143 0.8381 0.955783 0.356502
+GGATGA 54.011587 0.875143 0.984139 0.372484
+GGATGC 50.260403 0.768546 1.30197 0.566793
+GGATGG 53.457564 0.873827 0.907831 0.330012
+GGATGT 52.149738 0.661955 1.007337 0.385731
+GGATTA 49.202345 0.83372 1.138853 0.463686
+GGATTC 45.686987 0.854028 1.334455 0.588137
+GGATTG 48.622494 0.806133 1.083902 0.430534
+GGATTT 46.947015 0.986867 1.321489 0.579586
+GGCAAA 64.615678 0.96487 0.881794 0.315917
+GGCAAC 60.956185 1.21912 1.027292 0.397249
+GGCAAG 64.938697 0.800219 0.865742 0.30733
+GGCAAT 64.038611 1.029843 1.165509 0.480061
+GGCACA 62.0795 0.804695 0.791023 0.268415
+GGCACC 59.868975 0.610898 0.796099 0.271002
+GGCACG 61.609601 0.642334 0.762252 0.253904
+GGCACT 61.47085 0.809525 0.832323 0.289708
+GGCAGA 65.973547 0.834663 0.810282 0.278277
+GGCAGC 62.795825 1.048075 0.958642 0.358102
+GGCAGG 65.417351 0.82604 0.883894 0.317046
+GGCAGT 64.906421 1.0646 1.388234 0.624046
+GGCATA 62.333691 0.913892 0.858362 0.303409
+GGCATC 59.396574 1.254848 1.048062 0.409358
+GGCATG 61.573261 1.170022 1.042001 0.405812
+GGCATT 60.812598 1.490444 1.310943 0.572662
+GGCCAA 65.085422 0.691583 0.678662 0.213306
+GGCCAC 63.088213 0.731921 0.641343 0.195956
+GGCCAG 65.380665 0.79574 0.700496 0.223682
+GGCCAT 65.012456 0.667624 0.725548 0.235788
+GGCCCA 63.13411 1.617232 0.73421 0.240023
+GGCCCC 60.397959 0.567792 0.626353 0.189126
+GGCCCG 62.73733 1.389503 0.695854 0.221462
+GGCCCT 61.648126 0.744284 0.693858 0.22051
+GGCCGA 64.930465 0.697958 0.659192 0.204193
+GGCCGC 62.757074 0.656823 0.644274 0.197301
+GGCCGG 64.022811 0.850451 0.696169 0.221613
+GGCCGT 63.636188 0.764322 0.987984 0.374669
+GGCCTA 61.648683 0.59918 0.642723 0.196588
+GGCCTC 59.279691 0.632162 0.702653 0.224716
+GGCCTG 60.811028 0.708331 0.814545 0.280476
+GGCCTT 59.883069 0.854423 1.239665 0.526598
+GGCGAA 67.49194 0.809346 0.810363 0.278318
+GGCGAC 63.144473 0.837407 0.88227 0.316173
+GGCGAG 67.121336 0.737126 0.791931 0.268877
+GGCGAT 65.757079 0.868145 1.085749 0.431635
+GGCGCA 62.8125 0.803919 0.748174 0.246903
+GGCGCC 60.844205 0.688487 0.727171 0.236579
+GGCGCG 62.524906 0.791802 0.738644 0.242201
+GGCGCT 62.581844 0.815033 0.793785 0.269822
+GGCGGA 63.743371 0.800664 0.823201 0.284959
+GGCGGC 59.405716 1.13402 1.058858 0.415699
+GGCGGG 62.905846 0.843853 0.882589 0.316344
+GGCGGT 62.158094 1.002786 1.233801 0.522866
+GGCGTA 55.419873 1.379085 1.110157 0.446272
+GGCGTC 50.29595 1.64534 1.488951 0.693176
+GGCGTG 54.403404 1.46917 1.22171 0.515199
+GGCGTT 52.372206 1.90233 1.441561 0.660347
+GGCTAA 61.486721 0.652166 0.678678 0.213313
+GGCTAC 58.342692 0.860497 0.767859 0.256711
+GGCTAG 61.458141 0.663392 0.719534 0.232863
+GGCTAT 60.138197 0.71789 0.765197 0.255377
+GGCTCA 56.838391 0.735642 0.814069 0.28023
+GGCTCC 55.030252 0.939626 0.893489 0.322223
+GGCTCG 56.759746 0.771619 0.800735 0.273373
+GGCTCT 55.938428 0.617937 0.749225 0.247424
+GGCTGA 55.720876 0.966389 0.909956 0.331172
+GGCTGC 51.161591 0.928959 1.172339 0.484287
+GGCTGG 55.763704 0.712376 0.860674 0.304636
+GGCTGT 54.273366 0.882773 1.093379 0.436193
+GGCTTA 51.308724 0.926802 1.08437 0.430813
+GGCTTC 46.564532 1.112271 1.340501 0.592138
+GGCTTG 50.761915 0.942962 1.07703 0.426446
+GGCTTT 48.126601 1.310105 1.286312 0.556598
+GGGAAA 73.598685 1.269422 1.410298 0.638982
+GGGAAC 68.654336 1.175 1.299927 0.565459
+GGGAAG 73.457782 1.138877 1.347113 0.596525
+GGGAAT 72.332492 1.182437 1.633249 0.796345
+GGGACA 61.846854 0.830701 0.794456 0.270164
+GGGACC 58.642148 0.870101 0.932651 0.343638
+GGGACG 61.247505 0.791203 0.832152 0.289618
+GGGACT 60.651511 0.935745 0.945357 0.350684
+GGGAGA 71.56218 1.285365 1.24277 0.528577
+GGGAGC 66.549304 1.154383 1.115262 0.449353
+GGGAGG 70.431896 1.42141 1.309936 0.572002
+GGGAGT 69.389243 1.272442 1.581114 0.75852
+GGGATA 62.419592 1.095364 1.07738 0.426654
+GGGATC 58.942198 1.347294 1.241475 0.527752
+GGGATG 61.738695 1.120778 1.138602 0.463533
+GGGATT 60.55199 1.711915 1.367636 0.610208
+GGGCAA 70.041549 0.994773 1.062823 0.418036
+GGGCAC 67.352855 0.990097 1.056873 0.414531
+GGGCAG 69.913275 1.040955 1.046695 0.408557
+GGGCAT 69.296119 1.02751 1.183319 0.491106
+GGGCCA 63.912008 0.790169 0.754828 0.250204
+GGGCCC 62.041437 0.56748 0.726808 0.236402
+GGGCCG 63.634035 0.796195 0.773986 0.25979
+GGGCCT 63.349142 0.73518 0.85944 0.30398
+GGGCGA 69.248704 0.945344 0.973578 0.366504
+GGGCGC 65.925221 0.783962 0.958354 0.357941
+GGGCGG 67.73595 0.995788 1.076203 0.425955
+GGGCGT 66.528951 0.982266 1.397765 0.630483
+GGGCTA 64.58173 0.717955 0.922959 0.338295
+GGGCTC 62.099611 1.392192 1.00205 0.382699
+GGGCTG 63.665815 0.757493 1.113201 0.448108
+GGGCTT 63.276604 1.042953 1.43972 0.659083
+GGGGAA 72.48197 1.604083 1.234555 0.523345
+GGGGAC 65.632835 0.868983 1.000487 0.381803
+GGGGAG 71.54498 1.296093 1.212382 0.509309
+GGGGAT 69.621174 1.170049 1.238412 0.525799
+GGGGCA 64.124111 1.269714 0.987665 0.374487
+GGGGCC 60.82268 0.810846 0.890886 0.320816
+GGGGCG 64.042483 1.712295 0.99597 0.379221
+GGGGCT 63.52842 1.577645 0.993354 0.377728
+GGGGGA 68.028656 1.049631 1.009358 0.386893
+GGGGGC 62.180964 0.714851 0.989789 0.375696
+GGGGGG 67.056205 1.25921 1.04822 0.40945
+GGGGGT 66.263962 0.925943 1.10355 0.442294
+GGGGTA 60.681155 0.940761 0.997475 0.38008
+GGGGTC 55.689155 1.095493 1.207022 0.505936
+GGGGTG 59.788141 0.885629 1.030307 0.399
+GGGGTT 57.582712 1.328991 1.309731 0.571868
+GGGTAA 59.03674 1.110699 0.836315 0.291795
+GGGTAC 55.371221 0.561269 0.803829 0.274959
+GGGTAG 58.541704 1.332589 0.841956 0.294752
+GGGTAT 57.301066 0.794048 0.840167 0.293813
+GGGTCA 51.118771 0.723927 0.928436 0.341311
+GGGTCC 49.212115 0.662978 0.965978 0.362221
+GGGTCG 50.869956 0.679928 0.913852 0.333301
+GGGTCT 50.368906 0.626978 0.897212 0.324239
+GGGTGA 55.413543 0.762268 0.876954 0.31332
+GGGTGC 51.546002 0.61528 1.003069 0.383282
+GGGTGG 54.703202 0.811024 0.869825 0.309507
+GGGTGT 53.595964 0.670868 0.910604 0.331526
+GGGTTA 49.591671 0.673545 0.968626 0.363711
+GGGTTC 46.113207 0.73453 1.098956 0.439535
+GGGTTG 49.027078 0.756836 0.940517 0.347995
+GGGTTT 47.406334 1.016595 1.097642 0.438747
+GGTAAA 62.326018 0.837773 0.762761 0.254159
+GGTAAC 59.192596 0.707617 0.734594 0.240211
+GGTAAG 62.664688 0.929355 0.810432 0.278354
+GGTAAT 61.723078 0.802161 0.81033 0.278302
+GGTACA 57.81169 1.092532 0.779029 0.262333
+GGTACC 55.94355 0.726131 0.681671 0.214726
+GGTACG 57.482735 0.919784 0.767224 0.256393
+GGTACT 57.152929 0.922103 0.738015 0.241891
+GGTAGA 61.865646 0.841189 0.823744 0.28524
+GGTAGC 59.13963 0.615847 0.750611 0.24811
+GGTAGG 61.586376 0.790598 0.78029 0.26297
+GGTAGT 60.968868 0.822126 0.926064 0.340004
+GGTATA 57.511214 0.727176 0.65687 0.203115
+GGTATC 55.30558 0.671105 0.763469 0.254513
+GGTATG 57.168919 0.677835 0.764162 0.254859
+GGTATT 56.241342 0.743361 0.974933 0.367269
+GGTCAA 59.007492 1.305208 1.052078 0.411713
+GGTCAC 57.296604 0.976891 0.894649 0.32285
+GGTCAG 58.771704 1.387455 1.152633 0.472127
+GGTCAT 58.762416 1.451589 1.043954 0.406953
+GGTCCA 54.858624 1.504198 1.091121 0.434843
+GGTCCC 53.375507 1.363424 1.038789 0.403937
+GGTCCG 54.429412 1.501637 1.076046 0.425862
+GGTCCT 53.823739 1.51441 0.890998 0.320877
+GGTCGA 58.064927 1.369463 1.122483 0.453724
+GGTCGC 56.595732 0.990704 0.915511 0.334209
+GGTCGG 57.354659 1.299496 1.088445 0.433244
+GGTCGT 57.093276 1.122717 1.064586 0.419077
+GGTCTA 54.880224 1.033485 0.863735 0.306262
+GGTCTC 53.320164 0.813814 0.713899 0.230133
+GGTCTG 54.262633 0.924225 0.822982 0.284845
+GGTCTT 53.617563 0.8266 0.833142 0.290136
+GGTGAA 59.213673 1.405317 0.998281 0.380541
+GGTGAC 54.568158 0.910535 0.752457 0.249026
+GGTGAG 58.07355 1.296662 0.939167 0.347246
+GGTGAT 57.315681 1.352808 0.931826 0.343182
+GGTGCA 54.025919 1.521012 1.06456 0.419061
+GGTGCC 52.029143 1.187509 0.902376 0.327042
+GGTGCG 53.726855 1.405246 0.993868 0.378021
+GGTGCT 53.44474 1.284745 0.901404 0.326514
+GGTGGA 57.27458 1.126294 1.005722 0.384804
+GGTGGC 54.385594 0.65345 0.840643 0.294063
+GGTGGG 56.565596 1.001651 0.829464 0.288216
+GGTGGT 56.38526 0.840528 0.820278 0.283442
+GGTGTA 51.833417 0.678262 0.738771 0.242263
+GGTGTC 47.950634 0.752566 0.805201 0.275663
+GGTGTG 51.087486 0.742214 0.764188 0.254873
+GGTGTT 49.472478 0.923349 0.822968 0.284837
+GGTTAA 53.273507 1.252996 0.871612 0.310461
+GGTTAC 50.559544 0.912039 0.796447 0.27118
+GGTTAG 52.866757 1.294277 0.900122 0.325817
+GGTTAT 51.913145 0.977529 0.77852 0.262076
+GGTTCA 47.24104 1.166567 1.02957 0.398572
+GGTTCC 45.59052 1.277484 1.048971 0.40989
+GGTTCG 47.052536 1.162012 0.99036 0.376021
+GGTTCT 46.552214 1.116407 0.828772 0.287856
+GGTTGA 50.030833 0.953113 0.936119 0.345556
+GGTTGC 47.164935 0.646308 0.853109 0.300628
+GGTTGG 49.550503 0.937542 0.762772 0.254165
+GGTTGT 48.868195 0.812068 0.69062 0.218968
+GGTTTA 45.737245 0.896357 0.897776 0.324545
+GGTTTC 42.639743 0.628669 0.770916 0.258246
+GGTTTG 45.104439 0.714133 0.680382 0.214117
+GGTTTT 43.647465 0.585411 0.648805 0.199386
+GTAAAA 62.737785 0.790556 0.705974 0.226311
+GTAAAC 58.529499 0.71591 0.741995 0.243851
+GTAAAG 62.5732 0.748984 0.712634 0.229521
+GTAAAT 61.42722 0.778945 0.851322 0.299684
+GTAACA 56.917576 0.701225 0.708982 0.227759
+GTAACC 54.676675 0.650833 0.715199 0.230761
+GTAACG 56.59177 0.678555 0.67711 0.212575
+GTAACT 56.175931 0.647872 0.638881 0.194829
+GTAAGA 63.355073 0.808532 0.756333 0.250953
+GTAAGC 59.537571 0.706183 0.81232 0.279327
+GTAAGG 62.22128 0.809936 0.760793 0.253176
+GTAAGT 61.623071 0.714268 1.02481 0.395811
+GTAATA 57.536293 0.748284 0.735696 0.240752
+GTAATC 54.709578 1.012571 0.931248 0.342863
+GTAATG 57.136585 0.81567 0.817504 0.282006
+GTAATT 56.062457 1.196025 1.054316 0.413028
+GTACAA 63.79599 0.969838 0.862959 0.305849
+GTACAC 61.517889 0.623082 0.657231 0.203282
+GTACAG 63.822023 1.037355 0.912677 0.332658
+GTACAT 63.407646 0.864801 0.820784 0.283704
+GTACCA 59.251057 0.951582 0.766976 0.256269
+GTACCC 57.793406 0.792378 0.737872 0.241821
+GTACCG 59.166875 0.908298 0.721457 0.233796
+GTACCT 58.790048 0.741126 0.681482 0.214637
+GTACGA 62.956131 0.958609 0.789643 0.267713
+GTACGC 60.2979 0.697972 0.689103 0.218247
+GTACGG 61.865531 0.985889 0.770581 0.258078
+GTACGT 61.091719 0.827153 0.904885 0.328407
+GTACTA 59.278892 0.662174 0.638564 0.194684
+GTACTC 57.214094 0.983951 0.678965 0.213449
+GTACTG 58.583502 0.591522 0.716383 0.231334
+GTACTT 57.601424 1.00359 0.977333 0.368626
+GTAGAA 64.904147 1.123802 0.868077 0.308574
+GTAGAC 59.576308 0.724405 0.684322 0.21598
+GTAGAG 63.897543 1.131565 0.807186 0.276683
+GTAGAT 62.75816 0.841628 0.799022 0.272497
+GTAGCA 59.694112 1.127232 0.742084 0.243894
+GTAGCC 57.042734 0.659197 0.668719 0.208636
+GTAGCG 59.701468 1.452549 0.779546 0.262594
+GTAGCT 59.395758 1.394968 0.796851 0.271387
+GTAGGA 62.508232 0.91526 0.881662 0.315846
+GTAGGC 57.92362 0.590954 0.79851 0.272235
+GTAGGG 61.870686 0.959272 0.734226 0.240031
+GTAGGT 60.923731 0.690276 0.837063 0.292186
+GTAGTA 55.194325 0.746071 0.829936 0.288463
+GTAGTC 50.819303 1.275784 1.090432 0.434431
+GTAGTG 54.712162 0.841071 0.85123 0.299635
+GTAGTT 52.479364 1.224906 1.045322 0.407754
+GTATAA 58.524922 0.830161 0.607521 0.180661
+GTATAC 55.302143 0.502808 0.630238 0.190888
+GTATAG 58.337845 0.747547 0.636998 0.193968
+GTATAT 57.20612 0.841434 0.640787 0.195701
+GTATCA 53.043533 0.618084 0.752251 0.248924
+GTATCC 51.289471 0.754133 0.845105 0.296407
+GTATCG 52.963012 0.618952 0.721834 0.23398
+GTATCT 52.296686 0.602659 0.657895 0.203591
+GTATGA 54.472337 0.717506 0.803079 0.274575
+GTATGC 50.308073 0.762179 0.950896 0.353771
+GTATGG 54.220061 0.673141 0.720931 0.233541
+GTATGT 52.654098 0.643678 0.766471 0.256015
+GTATTA 49.743429 0.760185 0.865571 0.307239
+GTATTC 45.661797 0.835346 0.990234 0.375949
+GTATTG 49.058831 0.65448 0.792712 0.269275
+GTATTT 46.913427 0.957363 0.904417 0.328153
+GTCAAA 62.196611 0.824252 0.789704 0.267744
+GTCAAC 58.412838 0.657157 0.790657 0.268229
+GTCAAG 62.342501 0.715933 0.83821 0.292787
+GTCAAT 61.532618 0.6652 0.913736 0.333237
+GTCACA 60.262921 0.727058 0.729956 0.23794
+GTCACC 58.405868 0.63784 0.705062 0.225872
+GTCACG 60.002063 0.681606 0.698023 0.222499
+GTCACT 59.726307 0.757616 0.7132 0.229794
+GTCAGA 63.76576 0.752547 0.804046 0.27507
+GTCAGC 60.768248 1.022046 0.908517 0.330386
+GTCAGG 63.331188 0.691235 0.777744 0.261684
+GTCAGT 62.816944 0.78071 1.113432 0.448248
+GTCATA 60.781936 0.751295 0.767897 0.25673
+GTCATC 57.985689 0.916822 0.862642 0.305681
+GTCATG 60.21958 0.729996 0.891147 0.320957
+GTCATT 59.173072 1.08845 1.144768 0.467303
+GTCCAA 63.998126 0.993556 0.952257 0.354531
+GTCCAC 61.50216 0.802748 0.797369 0.271651
+GTCCAG 64.44717 1.209747 1.130833 0.458797
+GTCCAT 63.854008 0.979999 1.032183 0.40009
+GTCCCA 61.28013 1.392944 1.041836 0.405716
+GTCCCC 59.637104 1.052131 0.88271 0.316409
+GTCCCG 61.117273 1.26396 0.974867 0.367232
+GTCCCT 60.68822 1.121274 0.971879 0.365545
+GTCCGA 63.747299 1.180084 1.043103 0.406456
+GTCCGC 61.582692 0.734148 0.776299 0.260956
+GTCCGG 63.356387 1.25391 1.063708 0.418559
+GTCCGT 62.339069 1.183575 1.171903 0.484016
+GTCCTA 60.581509 0.799587 0.720306 0.233237
+GTCCTC 58.437881 0.701599 0.676683 0.212373
+GTCCTG 59.69943 0.838584 0.86453 0.306685
+GTCCTT 58.546052 1.016346 1.110141 0.446262
+GTCGAA 65.122676 1.207941 0.992611 0.377304
+GTCGAC 61.012685 0.681461 0.734348 0.240091
+GTCGAG 64.746206 1.084918 0.957457 0.357438
+GTCGAT 63.375265 0.886388 0.942157 0.348905
+GTCGCA 61.571065 1.368467 0.877323 0.313517
+GTCGCC 59.391345 0.813721 0.701846 0.224329
+GTCGCG 61.17222 1.103927 0.836596 0.291942
+GTCGCT 60.85272 1.130419 0.839938 0.293693
+GTCGGA 61.750266 0.785548 0.871134 0.310206
+GTCGGC 57.714431 0.975711 0.933834 0.344292
+GTCGGG 61.250259 0.674511 0.835458 0.291346
+GTCGGT 60.440192 0.776868 1.111427 0.447038
+GTCGTA 53.991249 1.452411 0.939139 0.34723
+GTCGTC 48.897859 1.501596 1.237913 0.525482
+GTCGTG 53.088453 1.301919 1.043559 0.406722
+GTCGTT 50.744876 1.546482 1.205868 0.505211
+GTCTAA 60.479046 1.158101 0.800695 0.273352
+GTCTAC 57.197705 0.568504 0.641865 0.196195
+GTCTAG 59.913606 1.352669 0.946152 0.351127
+GTCTAT 58.945078 0.822409 0.776067 0.260838
+GTCTCA 56.374275 0.996218 0.743911 0.244796
+GTCTCC 54.417073 0.809551 0.664041 0.20645
+GTCTCG 56.212804 0.798569 0.632957 0.192125
+GTCTCT 55.330412 0.731754 0.621739 0.18704
+GTCTGA 54.930665 0.962327 0.805459 0.275796
+GTCTGC 50.118524 0.767071 0.86899 0.309061
+GTCTGG 54.949547 0.695805 0.718725 0.23247
+GTCTGT 53.295021 0.619401 0.790248 0.26802
+GTCTTA 50.160397 0.650738 0.784648 0.265176
+GTCTTC 45.282336 0.884417 0.889467 0.32005
+GTCTTG 49.538954 0.70976 0.734865 0.240344
+GTCTTT 46.722329 1.035656 0.849478 0.298711
+GTGAAA 67.692039 1.12039 1.114876 0.44912
+GTGAAC 62.932734 0.859406 1.071234 0.423009
+GTGAAG 67.602062 1.170502 1.174993 0.485932
+GTGAAT 66.040045 1.313205 1.358309 0.603977
+GTGACA 58.857845 0.856212 0.784479 0.265091
+GTGACC 56.408423 0.578852 0.697296 0.222151
+GTGACG 58.326513 0.854836 0.776634 0.261124
+GTGACT 58.251059 0.771523 0.746058 0.245856
+GTGAGA 65.946611 1.076022 1.026759 0.39694
+GTGAGC 61.326326 0.803358 0.985595 0.37331
+GTGAGG 65.164669 1.103597 1.027048 0.397108
+GTGAGT 63.839498 1.064971 1.28725 0.557207
+GTGATA 58.718127 0.866863 0.896909 0.324075
+GTGATC 55.096087 1.080113 0.972029 0.36563
+GTGATG 58.151218 0.795379 0.992787 0.377404
+GTGATT 56.871256 1.514579 1.112361 0.447601
+GTGCAA 67.142433 1.070556 1.202835 0.503306
+GTGCAC 64.29556 0.914684 1.021798 0.394067
+GTGCAG 67.189935 1.229702 1.31129 0.572889
+GTGCAT 66.210103 1.232879 1.330406 0.585462
+GTGCCA 61.900927 1.330924 1.103336 0.442165
+GTGCCC 59.946988 0.962073 0.929722 0.342021
+GTGCCG 61.53503 1.254141 1.095658 0.437558
+GTGCCT 61.313345 1.301509 1.015591 0.390482
+GTGCGA 66.278194 1.423116 1.189324 0.494849
+GTGCGC 62.952797 1.024493 0.873794 0.311628
+GTGCGG 65.141647 1.188894 1.198206 0.500403
+GTGCGT 63.636092 1.28938 1.425295 0.649202
+GTGCTA 61.659054 0.882728 0.845569 0.296651
+GTGCTC 59.232872 0.802966 0.884585 0.317418
+GTGCTG 60.622073 0.995957 1.038937 0.404023
+GTGCTT 59.80118 1.068704 1.306733 0.569905
+GTGGAA 65.952614 1.77126 1.333485 0.587496
+GTGGAC 59.174781 1.059244 0.841259 0.294386
+GTGGAG 64.742437 1.736251 1.231526 0.52142
+GTGGAT 63.47556 1.26933 1.217932 0.512811
+GTGGCA 59.828984 1.96876 1.031663 0.399787
+GTGGCC 56.859242 1.160231 0.854754 0.301498
+GTGGCG 59.296465 1.52869 1.034645 0.401522
+GTGGCT 58.780713 1.282116 0.957476 0.357449
+GTGGGA 61.073584 1.157544 1.09697 0.438344
+GTGGGC 55.205783 0.712148 1.030132 0.398898
+GTGGGG 60.043939 0.9905 0.961062 0.35946
+GTGGGT 59.556595 0.858083 0.940742 0.34812
+GTGGTA 53.835454 0.821367 0.855815 0.302059
+GTGGTC 48.612468 0.95939 1.012957 0.388964
+GTGGTG 53.14799 0.752327 0.88686 0.318643
+GTGGTT 50.6252 0.931264 1.032558 0.400308
+GTGTAA 54.755506 1.061039 0.824627 0.285699
+GTGTAC 51.089726 0.885631 0.780672 0.263164
+GTGTAG 54.152201 1.108112 0.820102 0.283351
+GTGTAT 52.943688 0.884207 0.74229 0.243996
+GTGTCA 47.296988 0.887159 0.903217 0.3275
+GTGTCC 45.217405 0.637621 0.894903 0.322988
+GTGTCG 46.866926 0.815257 0.927294 0.340682
+GTGTCT 46.458161 0.628107 0.788519 0.267141
+GTGTGA 50.700171 0.735696 0.849187 0.298557
+GTGTGC 46.982121 0.669773 0.940783 0.348142
+GTGTGG 50.047436 0.85419 0.762852 0.254205
+GTGTGT 48.938085 0.633435 0.718609 0.232413
+GTGTTA 45.670627 0.676339 0.930944 0.342695
+GTGTTC 42.286324 0.664029 0.932554 0.343585
+GTGTTG 45.048399 0.615044 0.768715 0.257141
+GTGTTT 43.293391 0.55339 0.78968 0.267732
+GTTAAA 61.731414 1.04503 0.928228 0.341197
+GTTAAC 58.513419 0.669195 0.721743 0.233936
+GTTAAG 62.407875 1.241874 1.028854 0.398156
+GTTAAT 61.259357 0.926804 0.969221 0.364046
+GTTACA 58.161005 1.265295 1.007464 0.385804
+GTTACC 56.325478 0.984648 0.844254 0.29596
+GTTACG 57.926833 1.203375 0.970343 0.364679
+GTTACT 57.439502 1.045497 0.919869 0.336598
+GTTAGA 61.541853 0.897098 1.043301 0.406572
+GTTAGC 58.831398 0.621527 0.803529 0.274805
+GTTAGG 61.320313 1.162997 0.994697 0.378494
+GTTAGT 60.684231 0.960286 1.089178 0.433681
+GTTATA 57.53006 0.676264 0.723322 0.234704
+GTTATC 55.096705 0.637533 0.764888 0.255223
+GTTATG 57.028615 0.742958 0.818292 0.282413
+GTTATT 55.991185 0.794652 0.982714 0.371675
+GTTCAA 60.182631 1.491241 1.330388 0.58545
+GTTCAC 58.290296 1.176959 1.085159 0.431283
+GTTCAG 60.293095 1.761741 1.410096 0.638845
+GTTCAT 60.147585 1.566201 1.288797 0.558212
+GTTCCA 56.435543 1.86564 1.35556 0.602144
+GTTCCC 55.008057 1.446211 1.182608 0.490664
+GTTCCG 56.322982 1.767571 1.329958 0.585167
+GTTCCT 55.723209 1.494186 1.260822 0.540136
+GTTCGA 59.58533 1.605845 1.371491 0.61279
+GTTCGC 57.803215 1.086011 1.116795 0.45028
+GTTCGG 58.982513 1.678442 1.316089 0.576037
+GTTCGT 58.52463 1.356602 1.353246 0.600603
+GTTCTA 56.124609 1.14183 1.090082 0.434222
+GTTCTC 54.063181 0.939445 0.886437 0.318416
+GTTCTG 55.383279 1.201007 1.043144 0.40648
+GTTCTT 54.30076 1.033125 1.042885 0.406328
+GTTGAA 58.540106 1.974852 1.161545 0.477614
+GTTGAC 53.708677 0.998897 0.792614 0.269225
+GTTGAG 57.416761 1.566653 1.105503 0.443468
+GTTGAT 56.476142 1.605847 1.046252 0.408298
+GTTGCA 53.874374 1.777551 1.132117 0.459578
+GTTGCC 51.729435 1.314083 0.951408 0.354057
+GTTGCG 53.642599 1.681074 1.07631 0.426019
+GTTGCT 53.340342 1.525658 1.015461 0.390407
+GTTGGA 56.784618 1.377495 1.153294 0.472534
+GTTGGC 53.467241 0.726549 0.916651 0.334833
+GTTGGG 55.989318 1.156514 0.996276 0.379396
+GTTGGT 55.733372 0.920066 0.950502 0.353551
+GTTGTA 50.685972 0.622461 0.734692 0.24026
+GTTGTC 46.702766 1.107515 0.793039 0.269442
+GTTGTG 50.012651 0.591364 0.733619 0.239733
+GTTGTT 48.257478 1.003977 0.8071 0.276639
+GTTTAA 53.686554 1.445418 1.029748 0.398675
+GTTTAC 50.869179 1.130338 0.8809 0.315437
+GTTTAG 53.543962 1.564576 1.055439 0.413688
+GTTTAT 52.336351 1.234963 0.898192 0.324771
+GTTTCA 47.836518 1.384418 1.013285 0.389153
+GTTTCC 45.978989 1.029889 0.941725 0.348666
+GTTTCG 47.698045 1.274858 0.941005 0.348266
+GTTTCT 47.017247 1.176431 0.839192 0.293301
+GTTTGA 50.003572 0.914014 0.983646 0.372204
+GTTTGC 47.023199 0.653192 0.875838 0.312722
+GTTTGG 49.816219 0.999944 0.837471 0.2924
+GTTTGT 48.996825 0.883385 0.742796 0.244246
+GTTTTA 45.57489 0.650736 0.852726 0.300426
+GTTTTC 42.42926 0.558402 0.715535 0.230924
+GTTTTG 45.080878 0.676814 0.627846 0.189803
+GTTTTT 43.34116 0.609377 0.58728 0.171708
+TAAAAA 62.256183 0.731501 0.663069 0.205997
+TAAAAC 57.981935 0.69146 0.72531 0.235672
+TAAAAG 62.380574 0.679251 0.666939 0.207803
+TAAAAT 61.149962 0.701392 0.864197 0.306508
+TAAACA 55.881263 0.666108 0.780065 0.262856
+TAAACC 53.671717 0.792826 0.903236 0.32751
+TAAACG 55.675092 0.687847 0.757567 0.251567
+TAAACT 55.111527 0.632819 0.69227 0.219754
+TAAAGA 62.267394 0.780359 0.704471 0.225589
+TAAAGC 58.323117 0.624088 0.791983 0.268903
+TAAAGG 61.402194 0.635524 0.705152 0.225916
+TAAAGT 60.522508 0.716161 0.984026 0.37242
+TAAATA 56.005795 0.635033 0.750191 0.247902
+TAAATC 52.702822 0.933702 0.93059 0.3425
+TAAATG 55.446877 0.693125 0.803078 0.274574
+TAAATT 54.136582 1.02721 0.984423 0.372645
+TAACAA 62.545991 0.973774 0.756306 0.250939
+TAACAC 60.359225 0.696054 0.620781 0.186608
+TAACAG 62.794309 1.192347 0.798193 0.272073
+TAACAT 62.487525 1.029712 0.848593 0.298244
+TAACCA 58.229436 1.059147 0.778772 0.262203
+TAACCC 56.452601 0.873907 0.736689 0.24124
+TAACCG 58.054201 1.077971 0.77945 0.262546
+TAACCT 57.568411 0.840781 0.694892 0.221003
+TAACGA 61.712302 1.022503 0.810907 0.278599
+TAACGC 59.207579 0.699946 0.727142 0.236565
+TAACGG 60.830922 1.007172 0.787736 0.266743
+TAACGT 60.136449 0.863838 0.901821 0.326741
+TAACTA 57.758501 0.606758 0.60727 0.180549
+TAACTC 55.369219 0.549084 0.604206 0.179184
+TAACTG 57.035284 0.678925 0.643656 0.197017
+TAACTT 55.678179 0.71737 0.843224 0.295418
+TAAGAA 66.33113 1.310587 0.866903 0.307949
+TAAGAC 60.328852 0.657267 0.701295 0.224065
+TAAGAG 65.494576 1.273717 0.86318 0.305967
+TAAGAT 63.920274 0.850643 0.823446 0.285085
+TAAGCA 60.649684 1.60385 0.887763 0.319131
+TAAGCC 57.20046 0.682409 0.884986 0.317634
+TAAGCG 59.881165 1.244491 0.829998 0.288495
+TAAGCT 59.784054 1.645939 0.798344 0.27215
+TAAGGA 62.689423 1.000077 0.852647 0.300384
+TAAGGC 58.332822 0.769929 0.931899 0.343223
+TAAGGG 61.695096 0.704717 0.756247 0.25091
+TAAGGT 61.288195 0.74642 0.86314 0.305946
+TAAGTA 54.471856 0.799432 0.922177 0.337866
+TAAGTC 49.173648 0.937257 1.109466 0.445855
+TAAGTG 53.814277 0.782082 0.959888 0.358801
+TAAGTT 51.111646 1.069685 1.09894 0.439525
+TAATAA 57.760468 0.892978 0.714199 0.230277
+TAATAC 54.368459 0.613184 0.738804 0.24228
+TAATAG 57.569412 1.027694 0.705692 0.226175
+TAATAT 56.217631 0.730754 0.692399 0.219815
+TAATCA 52.06946 0.699976 0.844181 0.295921
+TAATCC 50.055464 0.677112 0.917788 0.335457
+TAATCG 51.967731 0.734591 0.805244 0.275686
+TAATCT 51.262184 0.592355 0.718336 0.232281
+TAATGA 53.304409 0.82901 0.96133 0.359609
+TAATGC 49.534962 0.973496 1.170967 0.483437
+TAATGG 53.157621 0.664317 0.754033 0.249809
+TAATGT 51.941523 0.596326 0.806091 0.276121
+TAATTA 48.899413 0.854696 1.066424 0.420163
+TAATTC 44.877633 0.812662 1.225646 0.51769
+TAATTG 48.174187 0.673315 0.929708 0.342013
+TAATTT 45.774628 0.70731 1.097117 0.438432
+TACAAA 63.97412 1.02727 0.790974 0.26839
+TACAAC 59.842811 0.814978 0.827587 0.287239
+TACAAG 64.685117 0.739068 0.786554 0.266143
+TACAAT 63.547979 0.768876 1.021397 0.393835
+TACACA 62.502608 0.713681 0.63917 0.194961
+TACACC 60.104978 0.538703 0.653749 0.201669
+TACACG 62.141323 0.710834 0.688896 0.218149
+TACACT 61.775975 0.572317 0.675429 0.211784
+TACAGA 65.603251 0.957228 0.758045 0.251806
+TACAGC 61.663876 0.917242 0.809561 0.277905
+TACAGG 65.405371 0.675526 0.794186 0.270026
+TACAGT 64.733026 0.820207 1.184209 0.49166
+TACATA 62.097174 0.760507 0.682789 0.215255
+TACATC 58.585415 0.955161 0.858446 0.303453
+TACATG 61.261623 0.945977 0.858967 0.30373
+TACATT 59.672019 1.231175 1.074652 0.425035
+TACCAA 65.905547 0.892584 0.79108 0.268444
+TACCAC 63.329234 0.639497 0.642721 0.196588
+TACCAG 66.599035 1.013052 0.882453 0.316272
+TACCAT 65.915173 0.832481 0.860449 0.304516
+TACCCA 63.312091 0.994733 0.738634 0.242196
+TACCCC 61.510486 0.716279 0.626743 0.189303
+TACCCG 63.158706 0.952295 0.726424 0.236215
+TACCCT 62.764164 0.889156 0.775096 0.260349
+TACCGA 65.941884 0.925901 0.785916 0.26582
+TACCGC 63.270832 0.593712 0.61935 0.185963
+TACCGG 65.339477 0.859669 0.868601 0.308854
+TACCGT 64.433379 0.901939 1.168179 0.481711
+TACCTA 62.218185 0.613561 0.61038 0.181938
+TACCTC 59.725355 1.065396 0.627524 0.189657
+TACCTG 61.371282 0.645932 0.79136 0.268586
+TACCTT 60.089807 0.918656 0.998173 0.380479
+TACGAA 67.955826 0.989619 0.899046 0.325234
+TACGAC 62.816519 0.703161 0.691877 0.219566
+TACGAG 67.61148 0.984748 0.867827 0.308441
+TACGAT 65.869917 0.778577 0.956721 0.357026
+TACGCA 64.039943 1.132837 0.794253 0.27006
+TACGCC 61.546059 0.734146 0.62579 0.188871
+TACGCG 63.686477 1.178568 0.746235 0.245944
+TACGCT 63.503442 1.095701 0.81131 0.278806
+TACGGA 63.520262 0.950312 0.757803 0.251685
+TACGGC 58.462108 0.868331 0.900278 0.325902
+TACGGG 62.800004 0.856794 0.814661 0.280536
+TACGGT 61.975052 0.863993 1.119978 0.452207
+TACGTA 54.118191 1.109125 1.050829 0.41098
+TACGTC 48.430686 1.468822 1.302768 0.567314
+TACGTG 53.216631 1.233919 1.106698 0.444187
+TACGTT 50.415672 1.683555 1.275431 0.549551
+TACTAA 62.08461 1.013577 0.654426 0.201982
+TACTAC 58.467814 0.540581 0.600467 0.177524
+TACTAG 61.87914 1.327961 0.693407 0.220295
+TACTAT 60.259181 0.869551 0.654826 0.202167
+TACTCA 57.547517 0.666293 0.657504 0.203409
+TACTCC 55.41203 0.599218 0.660777 0.20493
+TACTCG 57.46304 0.708632 0.670826 0.209622
+TACTCT 56.621194 0.585089 0.620669 0.186557
+TACTGA 55.203163 1.023127 0.797242 0.271586
+TACTGC 50.609162 0.843107 1.038865 0.403982
+TACTGG 55.636011 0.616073 0.703563 0.225153
+TACTGT 53.945481 0.77317 0.847355 0.297592
+TACTTA 50.688471 0.761081 0.947326 0.351781
+TACTTC 45.605834 0.849873 1.196361 0.499248
+TACTTG 49.810405 0.673172 0.910701 0.331579
+TACTTT 46.931669 1.010961 1.060831 0.416862
+TAGAAA 69.091568 0.962207 1.067641 0.420882
+TAGAAC 63.780441 1.305202 0.941541 0.348563
+TAGAAG 69.379913 0.963197 1.070872 0.422794
+TAGAAT 67.878181 0.90276 1.236901 0.524838
+TAGACA 60.021226 1.098199 0.679532 0.213716
+TAGACC 56.630768 0.596082 0.677091 0.212566
+TAGACG 59.145602 0.657492 0.675407 0.211773
+TAGACT 58.643401 0.588342 0.699172 0.223048
+TAGAGA 67.72114 0.967324 0.971156 0.365137
+TAGAGC 62.496217 1.149517 0.885843 0.318096
+TAGAGG 66.94642 0.891532 0.971186 0.365154
+TAGAGT 65.487298 0.831475 1.219292 0.51367
+TAGATA 58.841649 0.782559 0.803162 0.274617
+TAGATC 54.756573 0.995899 1.0289 0.398183
+TAGATG 58.19343 0.758714 0.957399 0.357406
+TAGATT 56.685558 1.052232 1.093673 0.436369
+TAGCAA 67.534136 0.840394 0.863611 0.306196
+TAGCAC 64.751887 0.668037 0.779625 0.262634
+TAGCAG 67.811247 0.893932 0.923322 0.338495
+TAGCAT 66.858791 0.881152 1.017821 0.391768
+TAGCCA 62.427687 0.85593 0.717084 0.231674
+TAGCCC 60.449837 0.61758 0.632958 0.192126
+TAGCCG 62.006025 0.813877 0.728963 0.237455
+TAGCCT 61.749406 0.739134 0.717622 0.231935
+TAGCGA 66.922518 0.913419 0.832835 0.289975
+TAGCGC 63.480918 0.609479 0.749183 0.247403
+TAGCGG 65.716921 0.828699 0.850251 0.299118
+TAGCGT 64.444818 0.84686 1.207407 0.506178
+TAGCTA 62.019478 0.582612 0.705551 0.226108
+TAGCTC 59.052721 0.896455 0.755481 0.250529
+TAGCTG 61.110403 0.654961 0.889609 0.320127
+TAGCTT 59.916675 0.903762 1.117596 0.450765
+TAGGAA 70.855381 1.825527 1.17862 0.488184
+TAGGAC 62.865116 1.620666 0.822223 0.284451
+TAGGAG 69.429665 1.814537 1.172777 0.484558
+TAGGAT 67.969224 1.363777 1.285576 0.556121
+TAGGCA 64.082248 1.746249 1.080251 0.428361
+TAGGCC 60.262793 0.989206 0.824507 0.285637
+TAGGCG 63.468796 1.292969 0.98864 0.375042
+TAGGCT 63.061228 1.604923 1.012334 0.388605
+TAGGGA 65.753438 1.053787 1.001617 0.38245
+TAGGGC 59.596414 0.71014 0.95064 0.353628
+TAGGGG 64.698771 0.943126 0.873977 0.311726
+TAGGGT 64.264808 0.967376 0.964378 0.361321
+TAGGTA 57.404433 0.773676 0.868472 0.308785
+TAGGTC 51.826561 0.839633 1.048032 0.40934
+TAGGTG 56.675055 0.803189 0.934148 0.344466
+TAGGTT 53.774782 1.009029 1.100107 0.440225
+TAGTAA 57.048706 0.965774 0.80292 0.274493
+TAGTAC 52.862831 0.571753 0.770658 0.258116
+TAGTAG 56.422017 1.072716 0.865652 0.307282
+TAGTAT 55.432552 1.30608 0.814687 0.280549
+TAGTCA 49.551461 0.969881 0.959001 0.358303
+TAGTCC 47.341845 0.655624 0.942078 0.348861
+TAGTCG 49.146593 0.772406 0.963387 0.360764
+TAGTCT 48.801876 0.78032 0.894112 0.32256
+TAGTGA 52.576635 0.698318 0.904502 0.328199
+TAGTGC 49.021533 0.806667 1.094891 0.437098
+TAGTGG 52.204851 0.750548 0.819726 0.283156
+TAGTGT 51.305095 0.5543 0.773496 0.259543
+TAGTTA 47.464364 0.640772 0.945789 0.350925
+TAGTTC 43.900424 0.7296 1.045053 0.407596
+TAGTTG 46.898493 0.630764 0.837811 0.292578
+TAGTTT 44.960281 0.745692 0.94477 0.350358
+TATAAA 62.982433 0.736026 0.690964 0.219132
+TATAAC 59.25729 0.602957 0.642322 0.196404
+TATAAG 63.589887 0.758231 0.719607 0.232898
+TATAAT 62.489318 0.720103 0.791704 0.268762
+TATACA 59.376327 0.914838 0.669026 0.208779
+TATACC 57.177435 0.644088 0.621525 0.186944
+TATACG 59.101477 1.038163 0.678197 0.213087
+TATACT 58.666022 0.745186 0.655317 0.202395
+TATAGA 62.79333 0.685843 0.702809 0.224791
+TATAGC 59.573065 0.654615 0.687023 0.21726
+TATAGG 62.428957 0.702925 0.726115 0.236064
+TATAGT 61.617704 0.691835 0.973315 0.366355
+TATATA 58.072757 0.728961 0.590958 0.173324
+TATATC 54.972094 0.666522 0.670809 0.209614
+TATATG 57.682816 0.563731 0.704448 0.225578
+TATATT 55.873111 1.221446 0.887193 0.318823
+TATCAA 61.663541 1.100293 0.903648 0.327734
+TATCAC 59.600935 0.776367 0.720715 0.233436
+TATCAG 61.976076 1.504875 1.007546 0.385851
+TATCAT 61.896273 1.063225 0.948194 0.352264
+TATCCA 58.195107 1.337426 0.892857 0.321881
+TATCCC 56.545483 1.139602 0.82463 0.2857
+TATCCG 58.169989 1.332497 0.879125 0.314484
+TATCCT 57.434264 1.19956 0.803221 0.274647
+TATCGA 61.294577 1.217575 0.945543 0.350788
+TATCGC 59.097633 0.762846 0.755103 0.250341
+TATCGG 60.670969 1.178406 0.974904 0.367253
+TATCGT 59.927585 1.07502 1.05991 0.416319
+TATCTA 57.390301 0.913095 0.685054 0.216327
+TATCTC 55.224528 0.502082 0.575819 0.166706
+TATCTG 56.694346 0.778675 0.742654 0.244176
+TATCTT 55.436823 0.651078 0.884658 0.317457
+TATGAA 61.223328 1.485137 1.028427 0.397908
+TATGAC 55.56019 1.046731 0.729551 0.237742
+TATGAG 60.109931 1.464425 0.955898 0.356566
+TATGAT 58.964415 1.35138 1.028289 0.397828
+TATGCA 56.208408 1.823511 1.139175 0.463883
+TATGCC 53.59341 1.266118 0.948996 0.352711
+TATGCG 55.941359 1.801178 1.098498 0.43926
+TATGCT 55.35985 1.267808 1.005442 0.384644
+TATGGA 58.36704 1.115109 0.920434 0.336908
+TATGGC 54.599826 0.695134 0.82443 0.285597
+TATGGG 57.503692 0.845719 0.753115 0.249353
+TATGGT 57.243759 0.817597 0.828906 0.287926
+TATGTA 51.110467 0.659213 0.733959 0.2399
+TATGTC 46.101392 0.87211 0.87562 0.312605
+TATGTG 50.300323 0.729843 0.749501 0.24756
+TATGTT 48.020497 0.818807 0.848104 0.297986
+TATTAA 55.031417 1.251381 0.868419 0.308757
+TATTAC 51.860946 0.903845 0.77697 0.261294
+TATTAG 54.625186 1.113887 0.886339 0.318363
+TATTAT 53.591607 0.908911 0.802757 0.274409
+TATTCA 48.952772 1.244021 1.000773 0.381967
+TATTCC 46.957685 0.984597 0.991131 0.37646
+TATTCG 48.957897 1.21748 0.972406 0.365843
+TATTCT 48.152567 1.01595 0.832366 0.28973
+TATTGA 50.771708 0.837537 0.931875 0.343209
+TATTGC 47.473566 0.603964 0.891761 0.321289
+TATTGG 50.650584 0.768883 0.725751 0.235887
+TATTGT 50.002 0.778579 0.691074 0.219184
+TATTTA 46.012925 0.592599 0.859894 0.304222
+TATTTC 42.771467 0.694942 0.889395 0.320011
+TATTTG 45.55758 0.592285 0.6909 0.219101
+TATTTT 43.66539 0.511451 0.666009 0.207368
+TCAAAA 62.306925 0.837886 0.754482 0.250032
+TCAAAC 57.670424 0.714553 0.79237 0.2691
+TCAAAG 62.227318 0.656433 0.791633 0.268725
+TCAAAT 60.82764 0.668851 0.956822 0.357083
+TCAACA 56.880418 0.616461 0.784903 0.265306
+TCAACC 54.70512 0.661253 0.853442 0.300804
+TCAACG 56.572859 0.620247 0.768182 0.256873
+TCAACT 56.088059 0.534173 0.749431 0.247525
+TCAAGA 63.553089 0.975162 0.764915 0.255236
+TCAAGC 58.919751 0.762725 0.82269 0.284693
+TCAAGG 62.279117 0.679897 0.773861 0.259727
+TCAAGT 61.30991 0.73754 1.06392 0.418684
+TCAATA 57.232315 0.722688 0.75963 0.252596
+TCAATC 54.080904 0.958276 0.959994 0.35886
+TCAATG 56.759674 0.817771 0.850848 0.299434
+TCAATT 55.522369 1.173652 1.033193 0.400677
+TCACAA 65.516214 0.749081 0.774893 0.260246
+TCACAC 62.783361 0.608609 0.651418 0.200591
+TCACAG 65.81564 1.067487 0.846851 0.297326
+TCACAT 65.07606 0.719517 0.805411 0.275771
+TCACCA 61.680341 0.852754 0.693676 0.220423
+TCACCC 59.858946 0.825481 0.673556 0.210903
+TCACCG 61.40736 0.756635 0.684717 0.216167
+TCACCT 61.014973 0.84956 0.72499 0.235516
+TCACGA 64.884389 0.817376 0.742123 0.243914
+TCACGC 61.887711 0.753457 0.684307 0.215973
+TCACGG 63.992987 0.793674 0.785748 0.265734
+TCACGT 62.909898 0.69216 1.037716 0.403311
+TCACTA 60.676869 0.692595 0.64548 0.197855
+TCACTC 57.777076 0.634342 0.664681 0.206749
+TCACTG 59.836918 0.690868 0.770643 0.258109
+TCACTT 58.416635 0.840764 1.01006 0.387296
+TCAGAA 65.594305 1.004118 0.817853 0.282186
+TCAGAC 59.215312 0.672003 0.747183 0.246413
+TCAGAG 64.508898 1.022325 0.815691 0.281068
+TCAGAT 62.750066 0.742893 0.864185 0.306502
+TCAGCA 60.041912 0.915817 0.795538 0.270716
+TCAGCC 57.328015 0.637872 0.729064 0.237504
+TCAGCG 59.765273 0.824284 0.792567 0.269201
+TCAGCT 59.495991 0.809969 0.78973 0.267757
+TCAGGA 62.698407 0.805818 0.858954 0.303723
+TCAGGC 57.473365 0.843016 0.970582 0.364813
+TCAGGG 61.663765 0.65668 0.761203 0.25338
+TCAGGT 60.819863 0.725893 0.922772 0.338193
+TCAGTA 54.100467 0.944253 0.970401 0.364712
+TCAGTC 49.191649 1.36229 1.245417 0.530267
+TCAGTG 53.599816 1.07385 1.03748 0.403174
+TCAGTT 50.90565 1.432273 1.213861 0.510242
+TCATAA 59.819306 0.65865 0.644573 0.197438
+TCATAC 56.112891 0.648639 0.727841 0.236907
+TCATAG 59.515188 0.728386 0.66009 0.20461
+TCATAT 58.160855 0.582463 0.68156 0.214674
+TCATCA 54.422756 0.618348 0.776987 0.261302
+TCATCC 52.437759 0.784494 0.899059 0.325241
+TCATCG 54.358241 0.6656 0.76436 0.254959
+TCATCT 53.562167 0.558356 0.692045 0.219646
+TCATGA 54.693626 0.900914 0.903574 0.327694
+TCATGC 50.040218 0.875917 1.193594 0.497516
+TCATGG 54.563963 0.667647 0.846522 0.297153
+TCATGT 52.857178 0.659144 0.97917 0.369666
+TCATTA 49.758803 0.799668 1.096716 0.438191
+TCATTC 45.373716 0.910872 1.346262 0.59596
+TCATTG 49.088839 0.684674 1.041573 0.405562
+TCATTT 46.565762 0.990471 1.219133 0.51357
+TCCAAA 63.974265 1.110224 0.822736 0.284717
+TCCAAC 59.363202 0.800261 0.872553 0.310964
+TCCAAG 64.402121 0.749037 0.849381 0.29866
+TCCAAT 63.233847 0.679832 0.972761 0.366043
+TCCACA 62.553534 0.679359 0.704628 0.225664
+TCCACC 60.239892 0.606904 0.71335 0.229867
+TCCACG 62.151748 0.623518 0.695357 0.221225
+TCCACT 61.821311 0.587748 0.737407 0.241593
+TCCAGA 65.85497 1.21575 0.858293 0.303372
+TCCAGC 61.877771 0.890002 0.839905 0.293676
+TCCAGG 65.668656 0.783836 0.878156 0.313964
+TCCAGT 64.895128 0.989756 1.332302 0.586714
+TCCATA 62.298001 0.842598 0.791466 0.26864
+TCCATC 58.892376 1.035445 0.908264 0.330248
+TCCATG 61.676832 0.956642 0.968831 0.363827
+TCCATT 60.306049 1.29812 1.178458 0.488083
+TCCCAA 67.168111 0.754033 0.855506 0.301896
+TCCCAC 64.498506 0.701779 0.729267 0.237603
+TCCCAG 68.18959 0.797085 0.811055 0.278675
+TCCCAT 67.166148 0.805942 0.875826 0.312716
+TCCCCA 65.200519 0.819535 0.727768 0.236871
+TCCCCC 63.245774 0.628102 0.587526 0.171816
+TCCCCG 65.079074 0.849902 0.734585 0.240207
+TCCCCT 64.596175 0.701124 0.735677 0.240743
+TCCCGA 67.750394 0.786229 0.775996 0.260802
+TCCCGC 64.503928 0.76592 0.734407 0.24012
+TCCCGG 66.948649 0.746092 0.856145 0.302234
+TCCCGT 65.867332 0.703438 1.267053 0.544145
+TCCCTA 63.606934 0.694765 0.689741 0.218551
+TCCCTC 60.777117 0.864798 0.699495 0.223203
+TCCCTG 62.77821 0.806433 0.895606 0.323369
+TCCCTT 61.178431 1.061396 1.170329 0.483042
+TCCGAA 68.273235 0.937272 0.811822 0.27907
+TCCGAC 62.711531 0.680543 0.745684 0.245672
+TCCGAG 67.706178 0.791072 0.817722 0.282118
+TCCGAT 66.066802 0.88687 1.022715 0.394598
+TCCGCA 64.548567 0.954627 0.688204 0.21782
+TCCGCC 61.835431 0.578494 0.608924 0.181287
+TCCGCG 64.366798 0.958587 0.711559 0.229002
+TCCGCT 63.831553 0.842277 0.742882 0.244288
+TCCGGA 63.876843 1.067487 0.857811 0.303117
+TCCGGC 58.197708 1.134315 1.045453 0.40783
+TCCGGG 63.14935 1.010147 0.872059 0.3107
+TCCGGT 61.879496 0.972873 1.142134 0.465692
+TCCGTA 53.724253 1.470497 1.149772 0.47037
+TCCGTC 48.199996 1.581974 1.390997 0.62591
+TCCGTG 52.756269 1.491687 1.239421 0.526443
+TCCGTT 50.159845 1.727223 1.376896 0.616416
+TCCTAA 63.165627 0.648011 0.621397 0.186886
+TCCTAC 59.129147 0.52901 0.623701 0.187926
+TCCTAG 62.886663 0.885841 0.650552 0.200192
+TCCTAT 61.167211 0.562926 0.667835 0.208222
+TCCTCA 58.770534 0.667042 0.636106 0.193561
+TCCTCC 56.46966 0.536881 0.650074 0.199971
+TCCTCG 58.7069 0.688564 0.628582 0.190137
+TCCTCT 57.688233 0.525193 0.649829 0.199858
+TCCTGA 55.5361 1.066238 0.843784 0.295712
+TCCTGC 50.525115 0.853662 1.058439 0.415452
+TCCTGG 55.930299 0.640892 0.749545 0.247582
+TCCTGT 54.074726 0.743581 0.94968 0.353093
+TCCTTA 50.671233 0.769862 0.940514 0.347993
+TCCTTC 45.431712 0.926215 1.267705 0.544565
+TCCTTG 50.022631 0.769993 0.91195 0.332261
+TCCTTT 47.095081 1.034906 1.121564 0.453168
+TCGAAA 68.329861 0.970983 1.001877 0.382599
+TCGAAC 62.572829 0.936073 0.947657 0.351965
+TCGAAG 68.369912 0.954799 1.003425 0.383486
+TCGAAT 66.80535 1.000098 1.203851 0.503943
+TCGACA 60.2179 0.598054 0.65566 0.202554
+TCGACC 57.151854 0.526254 0.709377 0.227949
+TCGACG 59.757685 0.598018 0.642913 0.196676
+TCGACT 59.112856 0.541469 0.72668 0.23634
+TCGAGA 66.764501 1.170102 0.904276 0.328076
+TCGAGC 60.999589 0.850839 0.910391 0.331409
+TCGAGG 65.647528 1.125348 0.898087 0.324714
+TCGAGT 64.157854 0.938956 1.177417 0.487437
+TCGATA 58.453737 0.832482 0.837682 0.29251
+TCGATC 54.262158 1.202664 1.098203 0.439083
+TCGATG 57.784121 0.932577 0.923704 0.338705
+TCGATT 56.009111 1.139066 1.122051 0.453462
+TCGCAA 68.49607 0.800963 0.928426 0.341305
+TCGCAC 65.527278 0.850554 0.861529 0.30509
+TCGCAG 68.970246 0.869408 0.903793 0.327813
+TCGCAT 67.91644 0.911661 1.078267 0.427181
+TCGCCA 64.365878 0.721999 0.651746 0.200743
+TCGCCC 62.166546 0.681932 0.601428 0.17795
+TCGCCG 64.154548 0.743846 0.669355 0.208933
+TCGCCT 63.661629 0.638086 0.69894 0.222937
+TCGCGA 68.217185 0.823331 0.835439 0.291336
+TCGCGC 64.424065 0.897005 0.837604 0.29247
+TCGCGG 66.913002 0.775745 0.89418 0.322597
+TCGCGT 65.460218 0.857778 1.293095 0.561007
+TCGCTA 63.07479 0.795476 0.803706 0.274896
+TCGCTC 59.640288 0.976453 0.822646 0.28467
+TCGCTG 62.161878 0.916211 0.924327 0.339048
+TCGCTT 60.637953 1.396595 1.118879 0.451541
+TCGGAA 66.175485 1.367437 0.998332 0.380571
+TCGGAC 58.278287 0.722531 0.837153 0.292233
+TCGGAG 65.072965 1.479363 0.960948 0.359395
+TCGGAT 62.974042 1.291671 0.971843 0.365525
+TCGGCA 60.21635 1.474105 0.998427 0.380625
+TCGGCC 56.419606 0.980174 0.872106 0.310725
+TCGGCG 59.660979 1.460945 0.981947 0.37124
+TCGGCT 59.2766 1.459828 0.977033 0.368457
+TCGGGA 60.081982 0.930333 1.001831 0.382573
+TCGGGC 53.871251 1.027892 1.315647 0.575747
+TCGGGG 59.253089 0.847453 0.943133 0.349447
+TCGGGT 58.834927 0.771667 0.946614 0.351384
+TCGGTA 52.153016 0.799208 1.109959 0.446152
+TCGGTC 46.420921 0.867253 1.322749 0.580415
+TCGGTG 51.442936 0.740758 1.064524 0.41904
+TCGGTT 48.447355 1.040105 1.311896 0.573287
+TCGTAA 53.302592 1.03383 0.947992 0.352151
+TCGTAC 49.40455 0.667656 0.917358 0.335221
+TCGTAG 52.717147 0.97681 0.998944 0.38092
+TCGTAT 51.467232 0.707733 0.827558 0.287223
+TCGTCA 45.992122 0.936981 1.101231 0.4409
+TCGTCC 44.067787 0.75559 1.147215 0.468802
+TCGTCG 45.740258 0.894282 1.079627 0.42799
+TCGTCT 45.135006 0.719944 0.970434 0.36473
+TCGTGA 48.978964 0.730325 1.046434 0.408404
+TCGTGC 45.350466 0.844061 1.182645 0.490687
+TCGTGG 48.565875 0.786505 0.930867 0.342653
+TCGTGT 47.561263 0.678653 0.830475 0.288744
+TCGTTA 44.229399 0.773554 1.101983 0.441352
+TCGTTC 40.885159 0.770648 1.112773 0.44785
+TCGTTG 43.675379 0.685143 0.934272 0.344535
+TCGTTT 41.861313 0.607251 0.926908 0.340469
+TCTAAA 64.571939 0.671426 0.682168 0.214961
+TCTAAC 60.382177 0.831662 0.686242 0.21689
+TCTAAG 65.21956 0.730194 0.786632 0.266183
+TCTAAT 63.776729 0.729803 0.893833 0.322409
+TCTACA 60.947436 0.908798 0.636935 0.193939
+TCTACC 58.787286 0.65795 0.592703 0.174092
+TCTACG 60.836527 0.792744 0.631576 0.191497
+TCTACT 60.338803 0.648512 0.664178 0.206514
+TCTAGA 64.342866 0.735402 0.705252 0.225964
+TCTAGC 61.162287 1.223693 0.78743 0.266588
+TCTAGG 64.003091 0.859273 0.830856 0.288942
+TCTAGT 63.167994 0.846027 1.111787 0.447255
+TCTATA 59.449616 0.840586 0.651338 0.200554
+TCTATC 56.069113 0.743989 0.750117 0.247865
+TCTATG 58.79662 0.797228 0.74428 0.244978
+TCTATT 57.334639 0.944362 0.990643 0.376182
+TCTCAA 64.068844 0.846331 0.789231 0.267503
+TCTCAC 61.66139 0.5978 0.625093 0.188556
+TCTCAG 64.871156 1.052717 0.965858 0.362153
+TCTCAT 63.982571 0.84889 0.896381 0.323788
+TCTCCA 60.980574 1.06011 0.816749 0.281615
+TCTCCC 59.080226 0.801023 0.68769 0.217576
+TCTCCG 60.732085 0.973679 0.797403 0.271668
+TCTCCT 60.257183 1.043563 0.786107 0.265916
+TCTCGA 63.932844 0.929712 0.83223 0.289659
+TCTCGC 61.237534 0.597121 0.619655 0.1861
+TCTCGG 63.375673 0.852336 0.859186 0.303846
+TCTCGT 62.238835 0.85188 1.057344 0.414808
+TCTCTA 59.695584 0.584381 0.60375 0.178981
+TCTCTC 57.013324 0.686432 0.620612 0.186532
+TCTCTG 58.957932 0.607269 0.727613 0.236796
+TCTCTT 57.600989 0.651554 0.987015 0.374118
+TCTGAA 59.943602 1.30697 0.919024 0.336134
+TCTGAC 53.493378 0.648523 0.760297 0.252928
+TCTGAG 58.508538 1.19348 0.907482 0.329822
+TCTGAT 57.495778 1.430568 0.93487 0.344866
+TCTGCA 55.001945 1.450739 1.078246 0.427169
+TCTGCC 52.169676 1.214033 0.934374 0.344591
+TCTGCG 54.40325 1.452346 1.037159 0.402987
+TCTGCT 54.077898 1.312525 0.9794 0.369796
+TCTGGA 58.029226 0.960493 0.851322 0.299684
+TCTGGC 53.814172 0.594903 0.821917 0.284292
+TCTGGG 56.998932 0.77319 0.747231 0.246437
+TCTGGT 56.620206 0.679875 0.757307 0.251438
+TCTGTA 50.685067 0.677263 0.774342 0.259969
+TCTGTC 45.792118 0.818437 0.914481 0.333645
+TCTGTG 49.86018 0.730636 0.776843 0.261229
+TCTGTT 47.620231 0.945521 0.874693 0.312109
+TCTTAA 54.764569 1.270565 0.868991 0.309062
+TCTTAC 51.461631 0.77566 0.715958 0.231129
+TCTTAG 54.331825 1.348798 0.864536 0.306688
+TCTTAT 53.372141 0.938201 0.774684 0.260141
+TCTTCA 48.276332 1.174284 1.001303 0.382271
+TCTTCC 46.097656 1.325667 0.983971 0.372388
+TCTTCG 47.989205 1.110418 0.969737 0.364337
+TCTTCT 47.371396 1.034328 0.851067 0.299549
+TCTTGA 50.59568 0.861289 0.902459 0.327087
+TCTTGC 47.166278 0.639668 0.919329 0.336302
+TCTTGG 50.292559 1.047877 0.717273 0.231766
+TCTTGT 49.339489 0.815921 0.673503 0.210878
+TCTTTA 45.492662 0.634858 0.865624 0.307267
+TCTTTC 42.366793 0.674291 0.925489 0.339687
+TCTTTG 44.953833 0.559033 0.671908 0.21013
+TCTTTT 43.238982 0.478911 0.683794 0.21573
+TGAAAA 63.918275 0.749496 0.842121 0.294839
+TGAAAC 59.862056 0.990966 1.003009 0.383248
+TGAAAG 63.891379 0.758045 0.848155 0.298013
+TGAAAT 62.802867 0.936092 1.171103 0.483521
+TGAACA 56.177085 0.861572 0.971592 0.365383
+TGAACC 53.575969 0.647207 0.965133 0.361746
+TGAACG 55.81292 0.753942 0.914263 0.333526
+TGAACT 55.228325 0.65971 0.869389 0.309274
+TGAAGA 63.491707 0.84504 0.880097 0.315006
+TGAAGC 59.839065 1.045096 1.047356 0.408944
+TGAAGG 62.756281 0.832516 0.9176 0.335353
+TGAAGT 61.814117 0.98156 1.269404 0.54566
+TGAATA 56.761728 0.894825 0.976252 0.368015
+TGAATC 53.852567 1.214435 1.252049 0.534509
+TGAATG 56.337339 1.00225 1.085 0.431188
+TGAATT 55.498255 1.238131 1.2596 0.539351
+TGACAA 62.272607 0.707482 0.682272 0.21501
+TGACAC 60.332089 0.620198 0.638379 0.194599
+TGACAG 62.263803 0.827301 0.728518 0.237237
+TGACAT 62.125733 0.6895 0.699218 0.22307
+TGACCA 57.456635 0.82473 0.700612 0.223737
+TGACCC 55.532424 0.543266 0.721775 0.233951
+TGACCG 57.315365 1.036464 0.72567 0.235847
+TGACCT 57.3149 1.082924 0.729864 0.237895
+TGACGA 61.192352 0.802395 0.717087 0.231676
+TGACGC 58.915846 0.678858 0.699102 0.223015
+TGACGG 60.132486 0.776106 0.676862 0.212458
+TGACGT 59.51915 0.668788 0.811754 0.279035
+TGACTA 57.667398 0.550465 0.649541 0.199725
+TGACTC 55.272611 0.45722 0.636508 0.193744
+TGACTG 56.858847 0.533179 0.672844 0.210569
+TGACTT 55.915787 0.675541 0.964616 0.361455
+TGAGAA 66.766943 1.179708 0.889865 0.320264
+TGAGAC 60.984626 0.775046 0.873703 0.311579
+TGAGAG 65.82825 1.096744 0.825637 0.286224
+TGAGAT 64.152495 0.790886 0.929203 0.341734
+TGAGCA 59.588764 0.890071 0.815558 0.280999
+TGAGCC 57.04323 0.748817 0.757493 0.251531
+TGAGCG 59.1563 0.796113 0.785395 0.265555
+TGAGCT 58.799227 0.67781 0.742292 0.243997
+TGAGGA 63.558796 0.813107 0.876565 0.313111
+TGAGGC 59.203331 0.64278 0.950902 0.353774
+TGAGGG 62.407147 0.742665 0.761006 0.253282
+TGAGGT 61.99782 0.791332 0.98117 0.3708
+TGAGTA 55.913724 0.712996 0.88755 0.319015
+TGAGTC 51.452848 1.07845 1.160022 0.476675
+TGAGTG 55.423328 0.79857 0.95779 0.357625
+TGAGTT 53.096086 1.159428 1.19213 0.496601
+TGATAA 56.85482 0.692018 0.673627 0.210937
+TGATAC 53.786289 0.642712 0.779805 0.262725
+TGATAG 56.582685 0.706179 0.685137 0.216366
+TGATAT 55.575649 0.630901 0.696205 0.22163
+TGATCA 51.008391 0.726058 0.866692 0.307836
+TGATCC 49.156301 0.869401 0.960942 0.359392
+TGATCG 50.775144 0.650249 0.841209 0.29436
+TGATCT 50.177213 0.625374 0.752536 0.249065
+TGATGA 53.461184 0.739372 0.900433 0.325986
+TGATGC 49.596077 0.76813 1.09119 0.434884
+TGATGG 52.996896 0.728984 0.790529 0.268163
+TGATGT 51.690223 0.57761 0.839113 0.293261
+TGATTA 48.74075 0.803555 1.064572 0.419069
+TGATTC 45.019479 0.783622 1.142478 0.465902
+TGATTG 48.025758 0.662288 0.937192 0.346151
+TGATTT 46.063465 0.775841 1.112442 0.44765
+TGCAAA 64.143521 0.92553 0.90578 0.328895
+TGCAAC 60.226972 0.996925 1.007948 0.386082
+TGCAAG 64.626228 0.655346 0.852779 0.300454
+TGCAAT 63.528431 0.874605 1.112956 0.44796
+TGCACA 61.739474 0.63144 0.74758 0.246609
+TGCACC 59.594262 0.726141 0.793612 0.269733
+TGCACG 61.378613 0.588797 0.73567 0.240739
+TGCACT 61.079201 0.625302 0.815665 0.281054
+TGCAGA 65.635493 0.893012 0.886611 0.318509
+TGCAGC 62.147838 0.970501 0.935047 0.344963
+TGCAGG 65.188629 0.706237 0.877527 0.313627
+TGCAGT 64.561932 0.866908 1.274481 0.548937
+TGCATA 61.80021 0.748836 0.807406 0.276796
+TGCATC 58.832403 1.154577 1.064471 0.419009
+TGCATG 61.26943 1.032828 0.96952 0.364215
+TGCATT 60.150516 1.26664 1.245225 0.530145
+TGCCAA 65.487146 0.694188 0.739698 0.242719
+TGCCAC 63.204083 0.74399 0.703631 0.225185
+TGCCAG 66.043613 0.729124 0.740504 0.243116
+TGCCAT 65.491517 0.608348 0.77353 0.25956
+TGCCCA 62.697273 0.760351 0.645163 0.197709
+TGCCCC 61.162034 0.768045 0.668496 0.208531
+TGCCCG 62.490006 0.671373 0.653746 0.201667
+TGCCCT 62.193674 0.68706 0.683424 0.215555
+TGCCGA 65.432932 0.69291 0.720618 0.233389
+TGCCGC 63.099359 0.780155 0.724322 0.235191
+TGCCGG 64.742914 0.667661 0.732673 0.23927
+TGCCGT 63.98379 0.645092 1.092162 0.435465
+TGCCTA 62.025509 0.727772 0.685543 0.216558
+TGCCTC 59.346894 0.693855 0.693198 0.220196
+TGCCTG 61.194328 0.717606 0.877653 0.313694
+TGCCTT 60.004937 0.878758 1.146973 0.468654
+TGCGAA 67.560268 0.855237 0.879337 0.314598
+TGCGAC 62.649046 0.687216 0.825913 0.286368
+TGCGAG 66.985127 0.741783 0.864484 0.306661
+TGCGAT 65.509654 0.788152 1.066817 0.420395
+TGCGCA 62.847947 0.782716 0.717831 0.232036
+TGCGCC 60.663909 0.638896 0.688686 0.218049
+TGCGCG 62.571444 0.72318 0.702337 0.224564
+TGCGCT 62.617759 0.856716 0.762078 0.253817
+TGCGGA 63.576109 0.87343 0.846995 0.297402
+TGCGGC 58.765808 0.972663 1.035156 0.40182
+TGCGGG 62.734984 0.792382 0.886221 0.318299
+TGCGGT 61.876892 0.949526 1.244784 0.529863
+TGCGTA 54.941362 1.248453 1.108629 0.44535
+TGCGTC 49.485388 1.506098 1.425875 0.649598
+TGCGTG 53.957692 1.457785 1.207085 0.505975
+TGCGTT 51.489052 1.688805 1.337427 0.590103
+TGCTAA 61.353294 0.613184 0.669407 0.208958
+TGCTAC 57.9628 0.696025 0.716655 0.231467
+TGCTAG 61.393037 0.733599 0.657168 0.203253
+TGCTAT 59.82014 0.588582 0.719742 0.232963
+TGCTCA 56.549287 0.610949 0.766015 0.255787
+TGCTCC 54.692552 0.753031 0.8437 0.295668
+TGCTCG 56.496051 0.632181 0.720142 0.233158
+TGCTCT 55.697177 0.540119 0.691814 0.219537
+TGCTGA 55.222228 0.962679 0.895031 0.323057
+TGCTGC 50.645765 0.827358 1.112089 0.447437
+TGCTGG 55.370092 0.65223 0.818124 0.282326
+TGCTGT 53.770894 0.758897 0.9986 0.380724
+TGCTTA 50.748864 0.832395 1.008779 0.38656
+TGCTTC 45.891107 0.965223 1.235306 0.523823
+TGCTTG 50.002648 0.810664 0.99964 0.381319
+TGCTTT 47.433649 1.100879 1.195927 0.498976
+TGGAAA 71.668834 1.150733 1.329309 0.584738
+TGGAAC 66.398539 1.081324 1.241984 0.528076
+TGGAAG 71.584925 1.164722 1.321456 0.579564
+TGGAAT 70.189024 1.21463 1.550612 0.736677
+TGGACA 60.618095 0.814378 0.750595 0.248103
+TGGACC 57.167025 0.667097 0.771995 0.258788
+TGGACG 59.966295 0.927301 0.802659 0.274359
+TGGACT 59.464424 0.756309 0.855812 0.302058
+TGGAGA 69.995795 1.116094 1.191129 0.495976
+TGGAGC 64.565556 0.967555 1.132785 0.459985
+TGGAGG 68.690766 1.049649 1.213011 0.509706
+TGGAGT 67.480688 1.145645 1.519538 0.714644
+TGGATA 60.684171 0.899612 0.977963 0.368983
+TGGATC 57.011292 1.137979 1.132625 0.459888
+TGGATG 60.071575 0.954709 1.043055 0.406428
+TGGATT 58.6591 1.151914 1.253402 0.535375
+TGGCAA 69.321346 0.953768 1.052351 0.411873
+TGGCAC 66.6461 0.831222 0.998324 0.380566
+TGGCAG 69.368873 0.95026 1.063268 0.418299
+TGGCAT 68.569043 0.975046 1.158302 0.475615
+TGGCCA 63.614197 0.740443 0.75402 0.249802
+TGGCCC 61.639332 0.542854 0.678827 0.213384
+TGGCCG 63.259708 0.768666 0.782925 0.264303
+TGGCCT 62.950365 0.681936 0.792194 0.269011
+TGGCGA 68.723589 0.938457 0.974861 0.367229
+TGGCGC 65.26971 0.713649 0.942716 0.349216
+TGGCGG 67.209589 0.938196 1.04424 0.407121
+TGGCGT 65.814181 0.965741 1.377117 0.616565
+TGGCTA 63.82702 0.689364 0.889716 0.320184
+TGGCTC 61.514607 1.007687 1.018791 0.392329
+TGGCTG 62.923177 0.765428 1.083626 0.43037
+TGGCTT 62.315337 0.985815 1.373108 0.613875
+TGGGAA 70.091433 1.870493 1.344091 0.594519
+TGGGAC 62.98686 1.095606 0.959983 0.358854
+TGGGAG 69.009059 1.684552 1.314375 0.574912
+TGGGAT 66.987241 1.288302 1.24304 0.52875
+TGGGCA 62.038212 1.543981 1.108575 0.445318
+TGGGCC 58.699618 1.076558 0.961451 0.359678
+TGGGCG 61.380528 1.450519 1.084983 0.431178
+TGGGCT 60.978882 1.373654 1.096702 0.438183
+TGGGGA 66.156272 1.337226 1.10903 0.445592
+TGGGGC 61.071192 1.355901 0.94484 0.350397
+TGGGGG 64.907948 1.123264 1.029928 0.398779
+TGGGGT 64.350481 1.057787 1.083839 0.430497
+TGGGTA 58.566697 0.92394 0.880757 0.31536
+TGGGTC 53.688559 0.860214 1.040781 0.405099
+TGGGTG 58.023058 0.811466 0.952122 0.354455
+TGGGTT 55.649367 1.033213 1.117803 0.45089
+TGGTAA 56.671507 1.059593 0.846719 0.297257
+TGGTAC 52.891366 0.694624 0.827718 0.287307
+TGGTAG 56.197549 1.19504 0.869556 0.309363
+TGGTAT 55.029663 1.094477 0.810451 0.278364
+TGGTCA 48.70574 0.952394 1.017026 0.39131
+TGGTCC 46.631578 0.72881 0.976205 0.367989
+TGGTCG 48.370612 1.065534 0.981153 0.37079
+TGGTCT 47.493448 0.672125 0.888797 0.319688
+TGGTGA 53.460141 1.240639 0.889411 0.320019
+TGGTGC 49.48081 0.624229 0.924642 0.339221
+TGGTGG 52.230407 0.924913 0.860845 0.304726
+TGGTGT 51.391991 0.6088 0.792483 0.269158
+TGGTTA 47.255993 0.629981 0.934378 0.344593
+TGGTTC 43.959265 0.656935 0.974059 0.366776
+TGGTTG 46.563825 0.614615 0.818585 0.282565
+TGGTTT 45.016841 0.69917 0.903888 0.327865
+TGTAAA 61.655961 0.890862 0.838397 0.292885
+TGTAAC 58.425721 0.518029 0.692527 0.219876
+TGTAAG 61.956819 0.943268 0.878128 0.313949
+TGTAAT 61.065803 0.734575 0.844248 0.295956
+TGTACA 57.334356 1.129319 0.904144 0.328004
+TGTACC 55.398913 0.855939 0.760567 0.253063
+TGTACG 57.196891 1.098656 0.89657 0.323891
+TGTACT 56.747049 0.958053 0.832761 0.289937
+TGTAGA 61.274076 0.799731 0.903857 0.327848
+TGTAGC 58.50045 0.502521 0.717721 0.231983
+TGTAGG 60.865879 0.817034 0.880814 0.315391
+TGTAGT 60.254661 0.798715 0.926746 0.340379
+TGTATA 57.007697 0.547495 0.653272 0.201449
+TGTATC 54.620714 0.561418 0.743832 0.244757
+TGTATG 56.544919 0.62316 0.753135 0.249363
+TGTATT 55.554004 0.601882 0.909643 0.331001
+TGTCAA 58.965635 1.230868 1.184285 0.491708
+TGTCAC 57.296661 0.982464 1.028695 0.398064
+TGTCAG 59.160144 1.475485 1.27981 0.552384
+TGTCAT 58.942074 1.557888 1.167675 0.4814
+TGTCCA 55.129305 1.309747 1.186044 0.492804
+TGTCCC 53.678581 1.32154 1.08487 0.431111
+TGTCCG 54.690801 1.258713 1.194471 0.498065
+TGTCCT 54.224615 1.368877 1.109586 0.445927
+TGTCGA 58.436836 1.416844 1.284405 0.555361
+TGTCGC 56.597308 0.911619 1.039866 0.404565
+TGTCGG 57.484295 1.395817 1.230387 0.520697
+TGTCGT 57.315126 1.088492 1.167074 0.481028
+TGTCTA 54.87611 0.927806 0.980763 0.370568
+TGTCTC 53.244324 0.705627 0.790621 0.26821
+TGTCTG 54.224325 1.039409 0.91934 0.336307
+TGTCTT 53.27321 0.788295 0.939899 0.347651
+TGTGAA 58.469682 1.447045 1.094831 0.437062
+TGTGAC 53.400377 0.836024 0.72493 0.235487
+TGTGAG 57.208697 1.331106 1.012109 0.388475
+TGTGAT 56.241929 1.407398 0.997862 0.380302
+TGTGCA 53.649137 1.840928 1.152928 0.472309
+TGTGCC 51.024721 1.227046 0.963643 0.360908
+TGTGCG 52.886002 1.540356 1.136258 0.462102
+TGTGCT 52.794048 1.35469 0.939031 0.34717
+TGTGGA 56.515887 1.232043 1.092695 0.435784
+TGTGGC 53.432039 0.685815 0.880176 0.315048
+TGTGGG 55.69799 1.091406 0.970254 0.364629
+TGTGGT 55.585635 0.892353 0.91072 0.331589
+TGTGTA 50.772695 0.559161 0.713135 0.229763
+TGTGTC 46.642415 0.725987 0.768388 0.256977
+TGTGTG 50.058024 0.529652 0.729532 0.237733
+TGTGTT 47.891218 1.311856 0.785836 0.265779
+TGTTAA 52.673732 1.492835 0.953018 0.354956
+TGTTAC 49.893519 0.983404 0.828714 0.287825
+TGTTAG 52.324921 1.489146 0.960975 0.35941
+TGTTAT 51.379545 1.20991 0.840528 0.294002
+TGTTCA 46.533063 1.14965 1.00122 0.382223
+TGTTCC 44.732622 0.948029 1.003214 0.383366
+TGTTCG 46.290913 1.019092 0.973011 0.366184
+TGTTCT 45.752581 0.967571 0.856547 0.302447
+TGTTGA 49.155914 0.886387 0.94852 0.352446
+TGTTGC 46.324459 0.612617 0.904989 0.328464
+TGTTGG 48.839667 0.913793 0.79289 0.269365
+TGTTGT 48.038919 0.764994 0.702201 0.224499
+TGTTTA 44.707861 0.729622 0.873194 0.311307
+TGTTTC 41.796246 0.525076 0.762717 0.254137
+TGTTTG 44.318467 0.724993 0.665296 0.207036
+TGTTTT 42.815838 0.494519 0.641465 0.196012
+TTAAAA 63.055644 0.79261 0.729404 0.23767
+TTAAAC 58.55684 0.665851 0.757501 0.251535
+TTAAAG 62.897605 0.716492 0.724108 0.235087
+TTAAAT 61.610559 0.855087 0.89934 0.325393
+TTAACA 57.145941 0.611401 0.699259 0.22309
+TTAACC 54.792921 0.649426 0.729916 0.237921
+TTAACG 56.828672 0.614009 0.669602 0.209049
+TTAACT 56.350758 0.561413 0.654634 0.202079
+TTAAGA 63.543769 0.676186 0.755404 0.250491
+TTAAGC 59.521957 0.753223 0.810618 0.27845
+TTAAGG 62.659548 0.690477 0.792314 0.269072
+TTAAGT 61.782185 0.841499 1.071004 0.422872
+TTAATA 57.436767 0.783122 0.750886 0.248247
+TTAATC 54.576038 1.114952 0.932891 0.343771
+TTAATG 57.071639 0.83852 0.839697 0.293566
+TTAATT 55.930426 1.065182 1.000155 0.381613
+TTACAA 64.574034 0.751187 0.844415 0.296044
+TTACAC 62.270108 0.676166 0.685182 0.216387
+TTACAG 64.954925 0.951475 0.86232 0.30551
+TTACAT 64.283749 0.840445 0.873301 0.311364
+TTACCA 60.416351 0.801974 0.703861 0.225296
+TTACCC 58.714959 0.659931 0.667089 0.207873
+TTACCG 60.247526 0.82209 0.695072 0.221089
+TTACCT 59.783989 0.757241 0.704754 0.225725
+TTACGA 63.972978 0.812454 0.787579 0.266664
+TTACGC 61.125167 0.647438 0.70497 0.225828
+TTACGG 63.029584 0.889535 0.811053 0.278674
+TTACGT 62.019905 0.760444 0.967807 0.36325
+TTACTA 60.070124 0.543169 0.653306 0.201464
+TTACTC 57.839484 1.035194 0.676134 0.212115
+TTACTG 59.316614 0.647602 0.755909 0.250742
+TTACTT 58.299389 0.906291 1.003248 0.383385
+TTAGAA 65.511271 1.003343 0.821614 0.284135
+TTAGAC 59.88724 0.590753 0.718023 0.232129
+TTAGAG 64.646336 1.016219 0.813039 0.279698
+TTAGAT 63.16258 0.771497 0.838624 0.293004
+TTAGCA 60.582364 1.203123 0.797935 0.271941
+TTAGCC 57.504898 0.597264 0.678639 0.213295
+TTAGCG 60.011882 1.004505 0.757267 0.251418
+TTAGCT 60.044416 1.421951 0.78603 0.265877
+TTAGGA 63.299151 0.949025 0.835561 0.2914
+TTAGGC 58.396784 0.715843 0.916501 0.334751
+TTAGGG 62.431351 1.030678 0.784794 0.265251
+TTAGGT 61.442099 0.662767 0.859739 0.304139
+TTAGTA 55.302941 0.793162 0.860798 0.304701
+TTAGTC 50.427965 1.101308 1.006109 0.385026
+TTAGTG 54.712992 1.009689 0.875092 0.312322
+TTAGTT 52.353315 1.254777 1.168163 0.481701
+TTATAA 58.955092 0.750274 0.636561 0.193768
+TTATAC 55.57541 0.546688 0.656476 0.202932
+TTATAG 58.757567 0.726641 0.645031 0.197648
+TTATAT 57.472171 0.649131 0.628373 0.190042
+TTATCA 53.462162 0.591837 0.731927 0.238904
+TTATCC 51.489229 0.657445 0.816641 0.281559
+TTATCG 53.337892 0.613136 0.708611 0.22758
+TTATCT 52.5968 0.519546 0.618498 0.18558
+TTATGA 54.601425 0.701814 0.802462 0.274258
+TTATGC 50.276105 0.760981 0.99201 0.376961
+TTATGG 54.355358 0.666922 0.73494 0.240381
+TTATGT 52.729686 0.636563 0.804072 0.275084
+TTATTA 49.647313 0.715501 0.896907 0.324074
+TTATTC 45.606738 0.780469 1.065189 0.419433
+TTATTG 49.041985 0.584556 0.80532 0.275725
+TTATTT 46.848401 0.912636 0.974352 0.366941
+TTCAAA 62.821816 0.959329 0.857068 0.302723
+TTCAAC 58.644979 0.753971 0.829793 0.288388
+TTCAAG 63.135077 0.65286 0.875967 0.312791
+TTCAAT 62.061642 0.724698 1.008463 0.386378
+TTCACA 61.039058 0.71508 0.729752 0.237841
+TTCACC 59.04913 0.582781 0.720665 0.233412
+TTCACG 60.792821 0.67267 0.725358 0.235696
+TTCACT 60.523306 0.609492 0.743482 0.244584
+TTCAGA 64.654427 0.816618 0.872736 0.311062
+TTCAGC 61.181129 1.054043 0.916602 0.334807
+TTCAGG 64.314851 0.635579 0.869334 0.309245
+TTCAGT 63.622861 0.837136 1.223977 0.516633
+TTCATA 61.244479 0.825704 0.851514 0.299785
+TTCATC 58.24826 1.004395 0.888526 0.319542
+TTCATG 60.655462 0.979288 0.963683 0.360931
+TTCATT 59.467552 1.125317 1.12908 0.45773
+TTCCAA 65.098402 0.935834 0.913677 0.333205
+TTCCAC 62.802765 0.676131 0.733061 0.23946
+TTCCAG 66.005955 0.951296 1.027337 0.397276
+TTCCAT 65.185261 0.85359 0.988114 0.374742
+TTCCCA 62.864381 1.020782 0.91996 0.336648
+TTCCCC 61.010547 0.760919 0.774224 0.25991
+TTCCCG 62.585616 1.034414 0.922195 0.337875
+TTCCCT 62.22545 1.030397 0.919079 0.336165
+TTCCGA 65.334771 0.989125 0.980515 0.370428
+TTCCGC 62.697381 0.629106 0.772319 0.258951
+TTCCGG 64.817002 0.931608 0.997224 0.379937
+TTCCGT 63.805291 0.950165 1.215216 0.511096
+TTCCTA 61.724017 0.582702 0.747984 0.246809
+TTCCTC 59.346561 0.735495 0.760886 0.253222
+TTCCTG 60.888432 0.793319 0.935223 0.345061
+TTCCTT 59.768476 0.857602 1.175409 0.48619
+TTCGAA 66.473348 0.942315 0.93982 0.347608
+TTCGAC 61.751292 0.661921 0.836158 0.291713
+TTCGAG 66.078314 1.036327 0.950963 0.353808
+TTCGAT 64.576533 0.825839 0.925951 0.339942
+TTCGCA 62.841736 1.016449 0.805506 0.27582
+TTCGCC 60.46236 0.686154 0.650008 0.19994
+TTCGCG 62.54889 1.087486 0.811318 0.27881
+TTCGCT 62.211204 1.105207 0.823145 0.284929
+TTCGGA 62.963944 0.743704 0.864737 0.306795
+TTCGGC 57.953998 0.94929 0.959031 0.35832
+TTCGGG 62.286212 0.746295 0.892982 0.321948
+TTCGGT 61.340806 0.879889 1.169456 0.482501
+TTCGTA 53.97812 1.267145 1.071528 0.423183
+TTCGTC 48.596471 1.394873 1.287062 0.557086
+TTCGTG 53.122729 1.322998 1.135872 0.461867
+TTCGTT 50.598527 1.663976 1.285145 0.555841
+TTCTAA 61.337059 0.760607 0.776061 0.260835
+TTCTAC 57.854154 0.540414 0.669916 0.209196
+TTCTAG 61.29006 0.731277 0.884334 0.317283
+TTCTAT 59.791336 0.63524 0.711828 0.229132
+TTCTCA 57.069919 0.752866 0.654245 0.201899
+TTCTCC 55.052202 0.586407 0.682489 0.215113
+TTCTCG 57.06944 0.765331 0.670023 0.209246
+TTCTCT 56.118699 0.603352 0.613419 0.183298
+TTCTGA 55.071085 1.062044 0.815633 0.281038
+TTCTGC 50.156808 0.822345 0.919333 0.336304
+TTCTGG 55.228229 0.644885 0.730541 0.238226
+TTCTGT 53.538491 0.622497 0.804238 0.275169
+TTCTTA 50.246745 0.742791 0.805328 0.275729
+TTCTTC 45.241369 0.877739 0.931781 0.343158
+TTCTTG 49.614817 0.819042 0.811454 0.278881
+TTCTTT 46.725009 0.95849 0.895779 0.323462
+TTGAAA 68.018218 1.061508 1.182617 0.490669
+TTGAAC 63.052821 0.943964 1.115198 0.449314
+TTGAAG 68.105002 1.130656 1.207732 0.506383
+TTGAAT 66.40198 1.088816 1.412425 0.640428
+TTGACA 59.109741 0.814696 0.762645 0.254101
+TTGACC 56.449791 0.567531 0.713387 0.229885
+TTGACG 58.621674 0.822346 0.752295 0.248946
+TTGACT 58.361086 0.6624 0.754686 0.250134
+TTGAGA 66.509823 1.011221 1.004115 0.383882
+TTGAGC 61.427204 0.868308 1.026788 0.396957
+TTGAGG 65.25151 1.015548 1.035708 0.402141
+TTGAGT 64.074171 0.982695 1.305935 0.569384
+TTGATA 58.762509 0.81418 0.955143 0.356143
+TTGATC 54.819258 1.019161 0.981833 0.371175
+TTGATG 58.088644 0.845524 1.018377 0.392089
+TTGATT 56.673796 1.673069 1.11345 0.448259
+TTGCAA 67.595901 1.10038 1.144103 0.466896
+TTGCAC 64.830071 0.868229 0.949733 0.353122
+TTGCAG 67.983749 1.133633 1.246819 0.531163
+TTGCAT 66.826337 1.148925 1.276864 0.550477
+TTGCCA 62.777338 1.165333 1.065667 0.419715
+TTGCCC 60.804637 0.870027 0.877503 0.313614
+TTGCCG 62.450714 1.142988 1.054493 0.413131
+TTGCCT 62.314979 0.983963 0.974269 0.366894
+TTGCGA 67.073348 1.157639 1.128983 0.457671
+TTGCGC 63.569141 0.829836 0.874663 0.312093
+TTGCGG 65.846081 1.062129 1.163512 0.478827
+TTGCGT 64.174331 1.228962 1.382594 0.620247
+TTGCTA 62.222679 0.797192 0.85643 0.302385
+TTGCTC 59.563374 0.804208 0.965433 0.361914
+TTGCTG 61.259255 0.946645 1.057503 0.414901
+TTGCTT 60.225757 0.978411 1.285723 0.556216
+TTGGAA 66.652655 1.713753 1.348435 0.597403
+TTGGAC 59.297537 1.271446 0.839475 0.29345
+TTGGAG 65.095699 1.56733 1.359906 0.605043
+TTGGAT 63.832559 1.262412 1.209304 0.507371
+TTGGCA 60.325308 1.605057 1.04555 0.407887
+TTGGCC 57.294439 1.064834 0.837154 0.292234
+TTGGCG 59.871191 1.603661 1.023231 0.394897
+TTGGCT 59.352296 1.350752 0.956968 0.357165
+TTGGGA 61.45547 1.092572 1.166772 0.480841
+TTGGGC 55.44852 0.769932 1.003417 0.383482
+TTGGGG 60.527435 0.9659 0.956657 0.356991
+TTGGGT 60.113364 0.901015 0.986915 0.374061
+TTGGTA 54.008775 0.7669 0.860026 0.304292
+TTGGTC 48.748983 0.903434 1.01529 0.390308
+TTGGTG 53.425595 0.720113 0.892225 0.321539
+TTGGTT 50.66957 0.883811 1.01344 0.389242
+TTGTAA 54.646561 1.114896 0.831308 0.289178
+TTGTAC 50.630589 0.581424 0.776279 0.260945
+TTGTAG 54.005354 1.079879 0.822798 0.284749
+TTGTAT 52.595253 0.803064 0.755142 0.250361
+TTGTCA 47.318332 0.975849 0.953767 0.355374
+TTGTCC 44.975128 0.67879 0.940228 0.347834
+TTGTCG 46.884673 1.044821 0.918703 0.335958
+TTGTCT 46.124093 0.736238 0.786653 0.266194
+TTGTGA 50.501879 0.715354 0.844049 0.295852
+TTGTGC 46.662237 0.640705 0.951915 0.35434
+TTGTGG 49.859591 0.98207 0.791694 0.268756
+TTGTGT 48.708932 0.581552 0.674908 0.211539
+TTGTTA 45.277965 0.604015 0.903767 0.327799
+TTGTTC 41.948935 0.681952 0.898406 0.324886
+TTGTTG 44.732926 0.565946 0.738324 0.242043
+TTGTTT 42.996588 0.598879 0.759443 0.252502
+TTTAAA 62.577602 0.863323 0.881954 0.316003
+TTTAAC 59.032611 0.648566 0.762494 0.254025
+TTTAAG 63.209956 0.929133 0.96257 0.360306
+TTTAAT 61.957126 0.847638 0.985642 0.373337
+TTTACA 58.916926 1.227403 0.940064 0.347743
+TTTACC 56.987618 0.819102 0.783139 0.264412
+TTTACG 58.863691 1.188154 0.914505 0.333658
+TTTACT 58.419254 1.018828 0.869325 0.30924
+TTTAGA 62.472308 0.906258 0.95677 0.357054
+TTTAGC 59.310853 0.596375 0.806539 0.276351
+TTTAGG 62.256943 0.779409 0.939922 0.347664
+TTTAGT 61.252849 0.93986 1.145649 0.467843
+TTTATA 58.123396 0.591389 0.717044 0.231655
+TTTATC 55.42543 0.732338 0.819122 0.282843
+TTTATG 57.636967 0.728912 0.850489 0.299244
+TTTATT 56.41231 0.794064 1.019459 0.392715
+TTTCAA 61.292198 1.262982 1.246491 0.530953
+TTTCAC 59.201187 1.022934 0.971445 0.3653
+TTTCAG 61.663634 1.556746 1.35958 0.604825
+TTTCAT 61.415756 1.172036 1.235951 0.524233
+TTTCCA 57.726196 1.511162 1.320156 0.578709
+TTTCCC 56.1285 1.240639 1.169892 0.482771
+TTTCCG 57.461672 1.555725 1.293051 0.560978
+TTTCCT 56.992436 1.365832 1.177568 0.48753
+TTTCGA 60.949681 1.34458 1.299007 0.564859
+TTTCGC 58.789229 0.903072 1.030497 0.39911
+TTTCGG 60.163272 1.339929 1.333596 0.587569
+TTTCGT 59.492611 1.217647 1.288866 0.558257
+TTTCTA 57.065872 0.932234 0.989799 0.375702
+TTTCTC 54.966214 0.754647 0.766186 0.255873
+TTTCTG 56.324057 1.027555 0.987388 0.37433
+TTTCTT 55.100082 0.935758 1.018029 0.391889
+TTTGAA 59.409726 2.16247 1.169055 0.482253
+TTTGAC 54.031473 0.914723 0.780846 0.263251
+TTTGAG 58.12005 1.587385 1.052187 0.411777
+TTTGAT 57.143926 1.658477 1.052818 0.412148
+TTTGCA 54.602114 1.759274 1.129299 0.457863
+TTTGCC 52.379622 1.33553 0.936867 0.345971
+TTTGCG 54.390037 1.762967 1.084514 0.430899
+TTTGCT 53.991543 1.472017 0.969566 0.364241
+TTTGGA 57.429463 1.319497 1.137605 0.462924
+TTTGGC 53.821759 0.646485 0.913693 0.333214
+TTTGGG 56.555537 1.049901 0.937769 0.346471
+TTTGGT 56.184853 0.926937 0.954 0.355505
+TTTGTA 50.944732 0.614476 0.731539 0.238715
+TTTGTC 46.357143 0.783452 0.821232 0.283936
+TTTGTG 50.19827 0.746855 0.742976 0.244335
+TTTGTT 48.157402 0.97543 0.786545 0.266139
+TTTTAA 54.426148 1.352145 1.03352 0.400868
+TTTTAC 51.215413 1.047345 0.853469 0.300818
+TTTTAG 54.093249 1.471634 1.047448 0.408998
+TTTTAT 52.771553 1.244983 0.896584 0.323899
+TTTTCA 48.311174 1.21806 0.981523 0.370999
+TTTTCC 46.315936 0.912541 0.912401 0.332507
+TTTTCG 48.197703 1.231961 0.938898 0.347097
+TTTTCT 47.453261 1.076056 0.805809 0.275976
+TTTTGA 50.194658 0.881493 0.975463 0.367569
+TTTTGC 47.12556 0.633507 0.880078 0.314996
+TTTTGG 50.096218 0.938579 0.821278 0.283961
+TTTTGT 49.214837 0.769967 0.714447 0.230397
+TTTTTA 45.877751 0.795009 0.856752 0.302556
+TTTTTC 42.378621 0.518937 0.700281 0.223579
+TTTTTG 45.36039 0.635336 0.590374 0.173067
+TTTTTT 43.744416 0.947752 0.599454 0.177074
diff --git a/src/cmake/FindHDF5.cmake b/src/cmake/FindHDF5.cmake
new file mode 100644
index 0000000..f41a32f
--- /dev/null
+++ b/src/cmake/FindHDF5.cmake
@@ -0,0 +1,52 @@
+# Find HDF5 (https://www.hdfgroup.org/)
+# Uses hint:
+# HDF5_ROOT
+# Sets:
+# HDF5_FOUND
+# HDF5_INCLUDE_DIRS
+# HDF5_LIBRARIES
+# Saves:
+# HDF5_ROOT
+# HDF5_INCLUDE_DIRS_CACHED
+# HDF5_LIBRARIES_CACHED
+
+if(NOT "${OLD_HDF5_ROOT}" OR NOT "${HDF5_ROOT}" STREQUAL "${OLD_HDF5_ROOT}")
+ message(STATUS "Detecting HDF5: redetecing with new HDF5_ROOT=${HDF5_ROOT} (OLD_HDF5_ROOT=${OLD_HDF5_ROOT}).")
+ unset(HDF5_INCLUDE_DIRS_CACHED CACHE)
+ unset(HDF5_LIBRARIES_CACHED CACHE)
+else()
+ message(STATUS "Detecting HDF5: HDF5_ROOT=${HDF5_ROOT} is not new; using cached paths.")
+ message(STATUS "HDF5_INCLUDE_DIRS_CACHED=${HDF5_INCLUDE_DIRS_CACHED}")
+ message(STATUS "HDF5_LIBRARIES_CACHED=${HDF5_LIBRARIES_CACHED}")
+endif()
+set(OLD_HDF5_ROOT ${HDF5_ROOT} CACHE INTERNAL "Last used value of HDF5_ROOT")
+
+# find headers
+find_path(HDF5_INCLUDE_DIRS_CACHED H5pubconf.h PATHS ${HDF5_ROOT}/include NO_DEFAULT_PATH)
+find_path(HDF5_INCLUDE_DIRS_CACHED H5pubconf.h PATH_SUFFIXES hdf5 hdf5/serial)
+if(HDF5_INCLUDE_DIRS_CACHED)
+ execute_process(
+ COMMAND grep H5_VERSION ${HDF5_INCLUDE_DIRS_CACHED}/H5pubconf.h
+ COMMAND awk "{print \$3}"
+ COMMAND tr -d "\"\n"
+ OUTPUT_VARIABLE HDF5_INCLUDE_DIRS_VERSION
+ )
+ message(STATUS "Found HDF5 headers version ${HDF5_INCLUDE_DIRS_VERSION} in: ${HDF5_INCLUDE_DIRS_CACHED}")
+endif()
+
+# find library
+find_library(HDF5_LIBRARIES_CACHED hdf5 PATHS ${HDF5_ROOT}/lib ${HDF5_ROOT}/lib64 NO_DEFAULT_PATH)
+find_library(HDF5_LIBRARIES_CACHED hdf5 PATH_SUFFIXES hdf5 hdf5/serial)
+
+include(FindPackageHandleStandardArgs)
+find_package_handle_standard_args(HDF5
+ REQUIRED_VARS HDF5_INCLUDE_DIRS_CACHED HDF5_LIBRARIES_CACHED
+ VERSION_VAR HDF5_INCLUDE_DIRS_VERSION
+ #"HDF5 library (https://www.hdfgroup.org/) not found. Specify location with -DHDF5_ROOT=<path>"
+ )
+mark_as_advanced(HDF5_INCLUDE_DIRS_CACHED HDF5_LIBRARIES_CACHED)
+
+if(HDF5_FOUND)
+ set(HDF5_INCLUDE_DIRS ${HDF5_INCLUDE_DIRS_CACHED})
+ set(HDF5_LIBRARIES ${HDF5_LIBRARIES_CACHED})
+endif()
diff --git a/src/get-dir-version b/src/get-dir-version
new file mode 100755
index 0000000..b11bc69
--- /dev/null
+++ b/src/get-dir-version
@@ -0,0 +1,112 @@
+#!/bin/bash
+trap 'echo "exit code $?: LINENO=$LINENO BASH_LINENO=\"${BASH_LINENO[@]}\" FUNCNAME=\"${FUNCNAME[@]}\"" >&2' ERR
+set -eEu -o pipefail
+prog_name=$(basename "$0")
+
+usage() {
+ cat <<EOF
+usage: $prog_name [-hv] [-d <dir>] [-c <ver_cmd>] [-f <ver_file>] [-r <proj_root>] [-o <out_file>] [-t <tag>]
+
+Determine source tree version using the first method that works:
+1. Change directory to <dir>, and run <ver_cmd> to describe its version.
+2. If <ver_file> exists, read version from that file.
+3. If the directory <proj_root> ends with "-[v]<num>.<num>[.<num>]", use the
+suffix as version.
+4. Failing all else, set version to "unknown".
+Write the version as a single CPP define rule, defining the symbol <tag>. Send
+the output to <out_file>. If <out_file> exists and already contains the correct
+definition, do not update it.
+
+The defaults are:
+<dir>: .
+<ver_cmd>: git describe --always --dirty --tags
+<ver_file>: VERSION
+<proj_root>: ..
+<out_file>: stdout
+<tag>: VERSION
+
+Other options:
+ -v : verbose messages
+ -h : this help
+EOF
+}
+
+log() {
+ ! [ $verbose ] || echo "$@" >&2
+}
+
+dir=
+version_command="git describe --always --dirty --tags"
+version_file="VERSION"
+project_root=..
+output_file=
+define_tag="VERSION"
+verbose=
+
+OPTIND=1
+while getopts "d:c:f:r:o:t:vh" OPT "$@"; do
+ case $OPT in
+ d)
+ dir=$OPTARG
+ ;;
+ c)
+ version_command=$OPTARG
+ ;;
+ f)
+ version_file=$OPTARG
+ ;;
+ r)
+ project_root=$OPTARG
+ ;;
+ o)
+ output_file=$OPTARG
+ ;;
+ t)
+ define_tag=$OPTARG
+ ;;
+ v)
+ verbose=1
+ ;;
+ h)
+ usage
+ exit 0
+ ;;
+ *)
+ usage >&2
+ exit 1
+ ;;
+ esac
+done
+shift $(($OPTIND - 1))
+
+! [ "$dir" ] || cd "$dir"
+version=$(
+ (eval "$version_command" 2>/dev/null && log "got version from: $version_command") ||
+ (cat "$version_file" 2>/dev/null && log "got version from file: $version_file") ||
+ ([ -d "$project_root" ] &&
+ name=$(basename "$(cd "$project_root"; pwd -P)") &&
+ [[ "$name" =~ -v?[0-9]+.[0-9]+(.[0-9]+)?$ ]] &&
+ echo "${name##*-}" &&
+ log "got version from project root folder") ||
+ (echo "unknown" && log "did not find version"))
+version=${version#v}
+log "found version=$version"
+
+if [ -r "$output_file" ]; then
+ existing_version=$(awk -v tag="$define_tag" '$1=="#define"&&$2==tag {print $3}' <"$output_file" |
+ sed 's/^"//;s/"$//')
+ if [ "$existing_version" ]; then
+ log "found existing_version=$existing_version"
+ if [ "$version" = "$existing_version" ]; then
+ log "version up to date"
+ exit 0
+ fi
+ fi
+fi
+
+echo "#define ${define_tag} \"$version\"" |
+if [ "$output_file" ]; then
+ cat >"$output_file"
+else
+ cat
+fi
diff --git a/src/nanocall/Builtin_Model.cpp b/src/nanocall/Builtin_Model.cpp
new file mode 100644
index 0000000..a41ac34
--- /dev/null
+++ b/src/nanocall/Builtin_Model.cpp
@@ -0,0 +1,17 @@
+#include "Builtin_Model.hpp"
+
+const unsigned Builtin_Model::num =
+#include "builtin_model_num.inl"
+ ;
+
+const unsigned Builtin_Model::strands[] =
+#include "builtin_model_strands.inl"
+ ;
+
+const std::string Builtin_Model::names[] =
+#include "builtin_model_names.inl"
+ ;
+
+const std::vector< float > Builtin_Model::init_lists[] =
+#include "builtin_model_init_lists.inl"
+ ;
diff --git a/src/nanocall/Builtin_Model.hpp b/src/nanocall/Builtin_Model.hpp
new file mode 100644
index 0000000..29ef1cf
--- /dev/null
+++ b/src/nanocall/Builtin_Model.hpp
@@ -0,0 +1,15 @@
+#ifndef __BUILTIN_MODEL_HPP
+#define __BUILTIN_MODEL_HPP
+
+#include <string>
+#include <vector>
+
+struct Builtin_Model
+{
+ static const unsigned num;
+ static const unsigned strands[];
+ static const std::string names[];
+ static const std::vector< float > init_lists[];
+}; // struct Builtin_Model
+
+#endif
diff --git a/src/nanocall/CMakeLists.txt b/src/nanocall/CMakeLists.txt
new file mode 100644
index 0000000..48b59a5
--- /dev/null
+++ b/src/nanocall/CMakeLists.txt
@@ -0,0 +1,28 @@
+message(STATUS "Processing: ${CMAKE_CURRENT_SOURCE_DIR}")
+
+add_executable(nanocall
+ nanocall.cpp
+ Builtin_Model.cpp
+ )
+target_link_libraries(nanocall
+ version
+ libhdf5
+ ${CMAKE_DL_LIBS}
+ ${ZLIB_LIBRARIES}
+ )
+install(TARGETS nanocall RUNTIME DESTINATION bin)
+
+if(NOT ${CMAKE_BUILD_TYPE} STREQUAL "Release")
+ add_executable(compute-state-transitions compute-state-transitions.cpp)
+
+ add_executable(compute-scaled-pore-model compute-scaled-pore-model.cpp)
+ target_link_libraries(compute-scaled-pore-model libhdf5 ${CMAKE_DL_LIBS} ${ZLIB_LIBRARIES})
+
+ add_executable(run-fwbw run-fwbw.cpp)
+ target_link_libraries(run-fwbw ${ZLIB_LIBRARIES})
+
+ add_executable(run-viterbi run-viterbi.cpp)
+ target_link_libraries(run-viterbi ${ZLIB_LIBRARIES})
+
+ add_executable(list-directory list-directory.cpp)
+endif()
diff --git a/src/nanocall/Event.hpp b/src/nanocall/Event.hpp
new file mode 100644
index 0000000..6f98ebf
--- /dev/null
+++ b/src/nanocall/Event.hpp
@@ -0,0 +1,96 @@
+#ifndef __EVENT_HPP
+#define __EVENT_HPP
+
+#include <algorithm>
+#include <cmath>
+#include <iostream>
+#include <vector>
+
+#include "fast5.hpp"
+#include "logger.hpp"
+#include "alg.hpp"
+
+template < typename Float_Type, unsigned Kmer_Size >
+class Event
+{
+public:
+ Float_Type mean;
+ Float_Type corrected_mean;
+ Float_Type stdv;
+ Float_Type start;
+ Float_Type length;
+ Float_Type log_mean;
+ Float_Type log_corrected_mean;
+ Float_Type log_stdv;
+ Float_Type log_start;
+ //
+ Float_Type orig_mean;
+ Float_Type p_model_state;
+ std::array< char, Kmer_Size > model_state;
+ unsigned model_state_idx;
+ int move;
+ //
+ void update_logs()
+ {
+ log_mean = std::log(mean);
+ log_corrected_mean = std::log(corrected_mean);
+ log_stdv = std::log(stdv);
+ log_start = std::log(start);
+ }
+ void set_model_state(const std::string& s)
+ {
+ assert(s.size() == Kmer_Size);
+ std::copy_n(s.begin(), Kmer_Size, model_state.begin());
+ }
+ friend std::ostream & operator << (std::ostream& os, const Event& ev)
+ {
+ os << ev.mean << '\t'
+ << ev.stdv << '\t'
+ << ev.start << '\t'
+ << ev.length;
+ return os;
+ }
+ friend std::istream & operator >> (std::istream& is, Event& ev)
+ {
+ is >> ev.mean
+ >> ev.stdv
+ >> ev.start
+ >> ev.length;
+ ev.corrected_mean = ev.mean;
+ ev.update_logs();
+ return is;
+ }
+}; // class Event
+
+template < typename Float_Type, unsigned Kmer_Size >
+struct Event_Sequence
+ : std::vector< Event< Float_Type, Kmer_Size > >
+{
+ typedef std::vector< Event< Float_Type, Kmer_Size > > Base;
+ using Base::Base;
+ void apply_drift_correction(Float_Type drift)
+ {
+ for (auto& e : *this)
+ {
+ e.corrected_mean -= drift * e.start;
+ e.log_corrected_mean = std::log(e.corrected_mean);
+ }
+ }
+ std::string get_base_seq() const
+ {
+ std::string res;
+ const Base& v = *this;
+ res.assign(v[0].model_state.begin(), v[0].model_state.end());
+ for (unsigned i = 1; i < v.size(); ++i)
+ {
+ unsigned a = std::min((unsigned)v[i].move, (unsigned)Kmer_Size);
+ unsigned b = Kmer_Size - a;
+ assert(std::string(v[i - 1].model_state.begin() + a, v[i - 1].model_state.end())
+ == std::string(v[i].model_state.begin(), v[i].model_state.begin() + b));
+ res += std::string(v[i].model_state.begin() + b, v[i].model_state.end());
+ }
+ return res;
+ }
+}; // struct Event_Sequence
+
+#endif
diff --git a/src/nanocall/Fast5_Summary.hpp b/src/nanocall/Fast5_Summary.hpp
new file mode 100644
index 0000000..1053cea
--- /dev/null
+++ b/src/nanocall/Fast5_Summary.hpp
@@ -0,0 +1,732 @@
+#ifndef __FAST5_SUMMARY_HPP
+#define __FAST5_SUMMARY_HPP
+
+#include <array>
+#include <string>
+#include <vector>
+#include <memory>
+
+#ifndef H5_HAVE_THREADSAFE
+#include <mutex>
+#endif
+
+#include "Pore_Model.hpp"
+#include "State_Transitions.hpp"
+#include "Event.hpp"
+#include "fast5.hpp"
+#include "alg.hpp"
+
+template < typename Float_Type, unsigned Kmer_Size >
+class Fast5_Summary
+{
+public:
+ typedef Pore_Model< Float_Type, Kmer_Size > Pore_Model_Type;
+ typedef Pore_Model_Dict< Float_Type, Kmer_Size > Pore_Model_Dict_Type;
+ typedef Pore_Model_Parameters< Float_Type > Pore_Model_Parameters_Type;
+ typedef Event< Float_Type, Kmer_Size > Event_Type;
+ typedef Event_Sequence< Float_Type, Kmer_Size > Event_Sequence_Type;
+ typedef State_Transition_Parameters< Float_Type > State_Transition_Parameters_Type;
+
+ std::string file_name;
+ std::string base_file_name;
+ std::string read_id;
+ std::string bc_grp;
+ std::array< std::array< std::string, 2 >, 3 > preferred_model;
+ std::map< std::array< std::string, 2 >, Pore_Model_Parameters_Type > pm_params_m;
+ std::map< std::array< std::string, 2 >, std::array< State_Transition_Parameters_Type, 2 > > st_params_m;
+ std::array< unsigned, 4 > strand_bounds;
+ std::array< Float_Type, 2 > time_length;
+ unsigned num_ed_events;
+ Float_Type sampling_rate;
+ Float_Type abasic_level;
+ bool valid;
+ bool scale_strands_together;
+
+ // from fast5 file
+ std::unique_ptr< std::vector< fast5::EventDetection_Event_Entry > > ed_events_ptr;
+ // filtered
+ std::array< std::unique_ptr< Event_Sequence_Type >, 2 > events_ptr;
+ //std::array< Event_Sequence_Type, 2 > events;
+
+ const std::vector< fast5::EventDetection_Event_Entry >& ed_events() const
+ {
+ assert(ed_events_ptr);
+ return *ed_events_ptr;
+ }
+ std::vector< fast5::EventDetection_Event_Entry >& ed_events()
+ {
+ assert(ed_events_ptr);
+ return *ed_events_ptr;
+ }
+ const Event_Sequence_Type& events(unsigned st) const
+ {
+ assert(st < 2);
+ assert(events_ptr[st]);
+ return *events_ptr[st];
+ }
+ Event_Sequence_Type& events(unsigned st)
+ {
+ assert(st < 2);
+ assert(events_ptr[st]);
+ return *events_ptr[st];
+ }
+
+ static unsigned& min_ed_events()
+ {
+ static unsigned _min_ed_events = 1000;
+ return _min_ed_events;
+ }
+
+ static unsigned& max_ed_events()
+ {
+ static unsigned _max_ed_events = 100000;
+ return _max_ed_events;
+ }
+
+ static std::string& eventdetection_group()
+ {
+ static std::string _eventdetection_group = "000";
+ return _eventdetection_group;
+ }
+
+ // percent of top events to ignore
+ static double& abasic_level_top_percent()
+ {
+ static double _abasic_level_top_percent = 1.0;
+ return _abasic_level_top_percent;
+ }
+
+ // what to add to top level
+ static double& abasic_level_top_offset()
+ {
+ static double _abasic_level_top_offset = 0.0;
+ return _abasic_level_top_offset;
+ }
+
+ // window size to consider for hairpin detection
+ static unsigned& hairpin_island_window_size()
+ {
+ static unsigned _hairpin_island_window_size = 10;
+ return _hairpin_island_window_size;
+ }
+
+ // window load to consider for hairpin detection
+ static unsigned& hairpin_island_window_load()
+ {
+ static unsigned _hairpin_island_window_load = 5;
+ return _hairpin_island_window_load;
+ }
+
+ Fast5_Summary() : valid(false) {}
+ Fast5_Summary(const std::string fn, const Pore_Model_Dict_Type& models, bool sst)
+ : valid(false) { summarize(fn, models, sst); }
+
+ void summarize(const std::string& fn, const Pore_Model_Dict_Type& models, bool sst)
+ {
+ valid = true;
+ // initialize fields
+ file_name = fn;
+ auto pos = file_name.find_last_of('/');
+ base_file_name = (pos != std::string::npos? file_name.substr(pos + 1) : file_name);
+ if (base_file_name.substr(base_file_name.size() - 6) == ".fast5")
+ {
+ base_file_name.resize(base_file_name.size() - 6);
+ }
+ read_id = base_file_name;
+ strand_bounds = {{ 0, 0, 0, 0 }};
+ time_length = {{ 0.0, 0.0 }};
+ num_ed_events = 0;
+ abasic_level = 0.0;
+ fast5::File f;
+ do
+ {
+ try
+ {
+ // open file
+ f.open(file_name); // can throw
+ // get sampling rate
+ if (not f.have_sampling_rate())
+ {
+ LOG("Fast5_Summary", info) << file_name << ": missing sampling rate" << std::endl;
+ break;
+ }
+ sampling_rate = f.get_sampling_rate(); // can throw
+ if (sampling_rate < 1000.0 or sampling_rate > 10000.0)
+ {
+ LOG("Fast5_Summary", warning) << file_name << ": unexpected sampling rate: " << sampling_rate << std::endl;
+ break;
+ }
+ // get ed event params and ed events
+ if (not f.have_eventdetection_events(eventdetection_group()))
+ {
+ LOG("Fast5_Summary", info) << file_name << ": missing eventdetection events" << std::endl;
+ break;
+ }
+ auto ed_params = f.get_eventdetection_event_params(eventdetection_group()); // can throw
+ if (not ed_params.read_id.empty())
+ {
+ read_id = ed_params.read_id;
+ }
+ load_ed_events(&f);
+ num_ed_events = ed_events().size();
+ if (num_ed_events < 100 + min_ed_events())
+ {
+ LOG("Fast5_Summary", info) << file_name << ": not enough eventdetection events: " << num_ed_events << std::endl;
+ num_ed_events = 0;
+ break;
+ }
+ if (num_ed_events > max_ed_events())
+ {
+ LOG("Fast5_Summary", info) << file_name << ": too many eventdetection events: " << num_ed_events << std::endl;
+ num_ed_events = 0;
+ break;
+ }
+ // get abasic level
+ abasic_level = detect_abasic_level();
+ if (abasic_level <= 1.0)
+ {
+ LOG("Fast5_Summary", info) << file_name << ": abasic level too low: " << abasic_level << std::endl;
+ num_ed_events = 0;
+ break;
+ }
+ // detect strands
+ detect_strands();
+ if (strand_bounds[1] <= strand_bounds[0])
+ {
+ LOG("Fast5_Summary", info) << file_name << ": no template strand detected" << std::endl;
+ num_ed_events = 0;
+ break;
+ }
+ scale_strands_together = (sst
+ and strand_bounds[1] - strand_bounds[0] >= min_ed_events()
+ and strand_bounds[3] - strand_bounds[2] >= min_ed_events());
+ // compute time lengths
+ load_events(&f);
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ if (events(st).size() < min_ed_events()) continue;
+ time_length[st] = events(st).rbegin()->start + events(st).rbegin()->length;
+ }
+ //
+ // compute initial model scalings
+ //
+ if (scale_strands_together)
+ {
+ auto r0 = alg::mean_stdv_of< Float_Type >(
+ events(0),
+ [] (const Event_Type& ev) { return ev.mean; });
+ auto r1 = alg::mean_stdv_of< Float_Type >(
+ events(1),
+ [] (const Event_Type& ev) { return ev.mean; });
+ for (const auto& p0 : models)
+ if (p0.second.strand() == 0 or p0.second.strand() == 2)
+ for (const auto& p1 : models)
+ if (p1.second.strand() == 1 or p1.second.strand() == 2)
+ {
+ std::array< std::string, 2 > m_name = {{ p0.first, p1.first }};
+ Pore_Model_Parameters_Type pm_params;
+ pm_params.scale = (r0.second / p0.second.stdv()
+ + r1.second / p1.second.stdv()) / 2;
+ pm_params.shift = (r0.first - pm_params.scale * p0.second.mean()
+ + r1.first - pm_params.scale * p1.second.mean()) / 2;
+ LOG("Fast5_Summary", debug)
+ << "initial_scaling read [" << read_id
+ << "] strand [2] model [" << m_name[0] << "+" << m_name[1]
+ << "] pm_params [" << pm_params << "]" << std::endl;
+ pm_params_m[m_name] = std::move(pm_params);
+ st_params_m[m_name][0] = State_Transition_Parameters_Type();
+ st_params_m[m_name][1] = State_Transition_Parameters_Type();
+ }
+ }
+ else // not scale_strands_together
+ {
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ if (events(st).size() < min_ed_events()) continue;
+ auto r = alg::mean_stdv_of< Float_Type >(
+ events(st),
+ [] (const Event_Type& ev) { return ev.mean; });
+ for (const auto& p : models)
+ {
+ if (p.second.strand() == st or p.second.strand() == 2)
+ {
+ std::array< std::string, 2 > m_name;
+ m_name[st] = p.first;
+ Pore_Model_Parameters_Type pm_params;
+ pm_params.scale = r.second / p.second.stdv();
+ pm_params.shift = r.first - pm_params.scale * p.second.mean();
+ LOG("Fast5_Summary", debug)
+ << "initial_scaling read [" << read_id
+ << "] strand [" << st
+ << "] model [" << m_name[st]
+ << "] pm_params [" << pm_params << "]" << std::endl;
+ pm_params_m[m_name] = std::move(pm_params);
+ st_params_m[m_name][st] = State_Transition_Parameters_Type();
+ }
+ }
+ }
+ }
+ // detect basecall group to write
+ auto bc_grp_l = f.get_basecall_group_list();
+ static const std::string bc_grp_prefix("Nanocall_");
+ std::set< std::string > used_tags;
+ for (const auto& bc_grp : bc_grp_l)
+ {
+ if (bc_grp.size() <= bc_grp_prefix.size()) continue;
+ auto p = std::mismatch(bc_grp_prefix.begin(),
+ bc_grp_prefix.end(),
+ bc_grp.begin());
+ if (p.first != bc_grp_prefix.end()) continue;
+ std::string tag(p.second, bc_grp.end());
+ std::clog << "found basecall group: " << tag << std::endl;
+ used_tags.emplace(std::move(tag));
+ }
+ for (unsigned i = 0; i < 1000; ++i)
+ {
+ std::ostringstream tmp;
+ tmp << std::setw(3) << std::setfill('0') << i;
+ if (not used_tags.count(tmp.str()))
+ {
+ bc_grp = bc_grp_prefix + tmp.str();
+ break;
+ }
+ }
+ if (bc_grp.empty())
+ {
+ LOG(error)
+ << "no available basecall tag" << std::endl;
+ std::exit(EXIT_FAILURE);
+ }
+ }
+ catch (hdf5_tools::Exception& e)
+ {
+ LOG(warning) << file_name << ": HDF5 error: " << e.what() << std::endl;
+ num_ed_events = 0;
+ }
+ } while (false);
+ drop_events();
+ ed_events_ptr.reset();
+ } // summarize
+
+ void load_events(fast5::File* f_p = nullptr)
+ {
+ assert(valid);
+ drop_events();
+ if (num_ed_events == 0)
+ {
+ return;
+ }
+ bool must_load_ed_events = not ed_events_ptr;
+ if (must_load_ed_events)
+ {
+#ifndef H5_HAVE_THREADSAFE
+ static std::mutex fast5_mutex;
+ std::lock_guard< std::mutex > fast5_lock(fast5_mutex);
+#endif
+ bool must_open_file = not f_p;
+ if (must_open_file)
+ {
+ f_p = new fast5::File(file_name);
+ }
+ assert(f_p->is_open());
+ load_ed_events(f_p);
+ if (must_open_file)
+ {
+ delete f_p;
+ }
+ }
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ events_ptr[st] = typename decltype(events_ptr)::value_type(new typename decltype(events_ptr)::value_type::element_type ());
+ for (unsigned j = strand_bounds[2 * st]; j < strand_bounds[2 * st + 1]; ++j)
+ {
+ if (filter_ed_event(ed_events()[j], abasic_level))
+ {
+ Event_Type e;
+ e.mean = ed_events()[j].mean;
+ e.corrected_mean = e.mean;
+ e.stdv = ed_events()[j].stdv;
+ e.start = (ed_events()[j].start - ed_events()[strand_bounds[scale_strands_together? 0 : 2 * st]].start) / sampling_rate;
+ e.length = ed_events()[j].length / sampling_rate;
+ e.update_logs();
+ events(st).emplace_back(std::move(e));
+ }
+ }
+ }
+ if (must_load_ed_events)
+ {
+ ed_events_ptr.reset();
+ }
+ }
+ void drop_events()
+ {
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ events_ptr[st].reset();
+ }
+ }
+
+ void add_basecall_seq(const std::string& name, unsigned st, const std::string& seq, int default_qual = 33) const
+ {
+ try
+ {
+ // open file
+ fast5::File f(file_name, true); // can throw
+ // write seq
+ f.add_basecall_seq(st, bc_grp, name, seq, default_qual);
+ }
+ catch (hdf5_tools::Exception& e)
+ {
+ LOG(warning) << file_name << ": HDF5 error: " << e.what() << std::endl;
+ }
+ }
+
+ void add_basecall_events(unsigned st, const Event_Sequence_Type& ev) const
+ {
+ try
+ {
+ // open file
+ fast5::File f(file_name, true); // can throw
+ // write seq
+ f.add_basecall_events(st, bc_grp, ev);
+ }
+ catch (hdf5_tools::Exception& e)
+ {
+ LOG(warning) << file_name << ": HDF5 error: " << e.what() << std::endl;
+ }
+ }
+
+ void add_basecall_model(unsigned st, const Pore_Model_Type& model) const
+ {
+ try
+ {
+ // open file
+ fast5::File f(file_name, true); // can throw
+ // write model params
+ f.add_basecall_model(st, bc_grp, model.get_state_vector());
+ }
+ catch (hdf5_tools::Exception& e)
+ {
+ LOG(warning) << file_name << ": HDF5 error: " << e.what() << std::endl;
+ }
+ }
+
+ void add_basecall_model_params(unsigned st, const Pore_Model_Parameters_Type& params) const
+ {
+ try
+ {
+ // open file
+ fast5::File f(file_name, true); // can throw
+ // write model params
+ f.add_basecall_model_params(st, bc_grp, params);
+ }
+ catch (hdf5_tools::Exception& e)
+ {
+ LOG(warning) << file_name << ": HDF5 error: " << e.what() << std::endl;
+ }
+ }
+
+ friend std::ostream& operator << (std::ostream& os, const Fast5_Summary& fs)
+ {
+ os << "[base_file_name=" << fs.base_file_name << " valid=" << fs.valid;
+ if (fs.valid)
+ {
+ os << " num_ed_events=" << fs.num_ed_events;
+ if (fs.num_ed_events > 0)
+ {
+ os << " read_id=" << fs.read_id
+ << " abasic_level=" << fs.abasic_level
+ << " strand_bounds=[" << fs.strand_bounds[0] << ","
+ << fs.strand_bounds[1] << ","
+ << fs.strand_bounds[2] << ","
+ << fs.strand_bounds[3]
+ << "] time_length=[" << fs.time_length[0] << "," << fs.time_length[1] << "]";
+ }
+ }
+ os << "]";
+ return os;
+ }
+
+ static void write_tsv_header(std::ostream& os)
+ {
+ os << "file_name" << "\tread_name" << "\tnum_ed_events" << "\tabasic_level"
+ << "\ttemplate_start_idx" << "\ttemplate_end_idx"
+ << "\tcomplement_start_idx" << "\tcomplement_end_idx";
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ os << "\tn" << st << "_model_name"
+ << "\tn" << st << "_scale"
+ << "\tn" << st << "_shift"
+ << "\tn" << st << "_drift"
+ << "\tn" << st << "_var"
+ << "\tn" << st << "_scale_sd"
+ << "\tn" << st << "_var_sd"
+ << "\tn" << st << "_p_stay"
+ << "\tn" << st << "_p_skip";
+ }
+ }
+
+ void write_tsv(std::ostream& os) const
+ {
+ os << base_file_name << '\t' << read_id << '\t' << num_ed_events << '\t' << abasic_level
+ << '\t' << strand_bounds[0] << '\t' << strand_bounds[1]
+ << '\t' << strand_bounds[2] << '\t' << strand_bounds[3];
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ os << '\t';
+ if (not preferred_model[st][st].empty())
+ {
+ os << preferred_model[st][st] << '\t';
+ pm_params_m.at(preferred_model[st]).write_tsv(os);
+ os << '\t';
+ st_params_m.at(preferred_model[st])[st].write_tsv(os);
+ }
+ else
+ {
+ os << ".\t";
+ Pore_Model_Parameters_Type().write_tsv(os);
+ os << '\t';
+ State_Transition_Parameters_Type().write_tsv(os);
+ }
+ }
+ }
+
+private:
+ void load_ed_events(fast5::File* f_p)
+ {
+ ed_events_ptr = decltype(ed_events_ptr)(
+ new typename decltype(ed_events_ptr)::element_type(
+ f_p->get_eventdetection_events(eventdetection_group())));
+ }
+
+ // crude detection of abasic level
+ Float_Type detect_abasic_level()
+ {
+ if (ed_events().size() < min_ed_events())
+ {
+ return 0.0;
+ }
+ //
+ // exclude top abasic_level_top_percent() levels
+ // add abasic_level_top_offset()
+ //
+ std::vector< Float_Type > s;
+ s.resize(ed_events().size());
+ unsigned i;
+ for (i = 0; i < ed_events().size(); ++i)
+ {
+ s[i] = ed_events()[i].mean;
+ }
+ std::sort(s.begin(), s.end());
+ return s[(double)s.size() * (1.0 - abasic_level_top_percent() / 100.0)] + abasic_level_top_offset();
+ } // detect_abasic_level()
+
+ std::vector< std::pair< unsigned, unsigned > > find_islands_5_consec() const
+ {
+ //
+ // find islands of >= 5 consecutive events at high level
+ //
+ std::vector< std::pair< unsigned, unsigned > > islands;
+ unsigned i = 0;
+ while (i < ed_events().size())
+ {
+ if (ed_events()[i].mean >= abasic_level)
+ {
+ unsigned j = i + 1;
+ while (j < ed_events().size() and ed_events()[j].mean >= abasic_level) ++j;
+ if (j - i >= 5)
+ {
+ islands.push_back(std::make_pair(i, j));
+ LOG("Fast5_Summary", debug) << "abasic_island [" << i << "," << j << "]" << std::endl;
+ }
+ i = j + 1;
+ }
+ else
+ {
+ ++i;
+ }
+ }
+ return islands;
+ }
+
+ std::vector< std::pair< unsigned, unsigned > > find_islands_5_of_10_consec() const
+ {
+ //
+ // find islands of >= 5/10 consecutive events at high level
+ //
+ std::vector< std::pair< unsigned, unsigned > > islands;
+ unsigned i = 0;
+ unsigned window_start = 0;
+ unsigned window_count = 0;
+ while (i < ed_events().size())
+ {
+ if (ed_events()[i].mean >= abasic_level)
+ {
+ while (window_start + 10 <= i)
+ {
+ if (ed_events()[window_start].mean >= abasic_level)
+ {
+ --window_count;
+ }
+ ++window_start;
+ }
+ while (window_start < i and ed_events()[window_start].mean < abasic_level)
+ {
+ ++window_start;
+ }
+ assert(i < window_start + 10);
+ ++window_count;
+ if (window_count >= 5)
+ {
+ islands.push_back(std::make_pair(window_start, i));
+ LOG("Fast5_Summary", debug) << "abasic_island [" << window_start << "," << i << "]" << std::endl;
+ window_start = i + 1;
+ window_count = 0;
+ }
+ }
+ ++i;
+ }
+ return islands;
+ }
+
+ // crude detection of hairpin islands
+ // look for >= hairping_window_load/hairpin_window_size consecutive events at high level
+ std::vector< std::pair< unsigned, unsigned > > find_hairpin_islands() const
+ {
+ std::vector< std::pair< unsigned, unsigned > > islands;
+ unsigned i = 0;
+ unsigned window_start = 0;
+ unsigned window_count = 0;
+ while (i < ed_events().size())
+ {
+ if (ed_events()[i].mean >= abasic_level)
+ {
+ while (window_start + hairpin_island_window_size() <= i)
+ {
+ if (ed_events()[window_start].mean >= abasic_level)
+ {
+ --window_count;
+ }
+ ++window_start;
+ }
+ while (window_start < i and ed_events()[window_start].mean < abasic_level)
+ {
+ ++window_start;
+ }
+ assert(i < window_start + hairpin_island_window_size());
+ ++window_count;
+ if (window_count >= hairpin_island_window_load())
+ {
+ islands.push_back(std::make_pair(window_start, i));
+ LOG("Fast5_Summary", debug) << "abasic_island [" << window_start << "," << i << "]" << std::endl;
+ window_start = i + 1;
+ window_count = 0;
+ }
+ }
+ ++i;
+ }
+ return islands;
+ } // find_hairpin_islands()
+
+ // crude detection of strands in event sequence
+ void detect_strands()
+ {
+ if (ed_events().size() < 100u)
+ {
+ return;
+ }
+ strand_bounds = { { 50, static_cast< unsigned >(ed_events().size() - 50), 0, 0 } };
+ LOG("Fast5_Summary", debug)
+ << "num_events=" << ed_events().size()
+ << " abasic_level=" << abasic_level << std::endl;
+ //
+ // find islands of consecutive events at high level
+ //
+ auto islands = find_islands_5_consec(); //find_hairpin_islands();
+ //
+ // merge islands within 50bp of each other
+ //
+ for (unsigned i = 1; i < islands.size(); ++i)
+ {
+ if (islands[i - 1].second + 50 >= islands[i].first)
+ {
+ LOG("Fast5_Summary", debug) << "merge_islands "
+ << "[" << islands[i - 1].first << "," << islands[i - 1].second << "] with "
+ << "[" << islands[i].first << "," << islands[i].second << "]" << std::endl;
+ islands[i - 1].second = islands[i].second;
+ islands.erase(islands.begin() + i);
+ i = 0;
+ }
+ }
+ LOG("Fast5_Summary", debug)
+ << "final_islands: " << alg::os_join(
+ islands, " ",
+ [] (const std::pair< unsigned, unsigned >& p) {
+ std::ostringstream tmp;
+ tmp << "[" << p.first << "," << p.second << "]";
+ return tmp.str();
+ }) << std::endl;
+ if (islands.empty())
+ {
+ LOG("Fast5_Summary", info)
+ << "template_only read_id=[" << read_id << "]" << std::endl;
+ return;
+ }
+ //
+ // pick island closest to the middle of the event sequence
+ //
+ auto dist_to_middle = [&] (const std::pair< unsigned, unsigned >& p) {
+ return std::min((unsigned)std::abs((long)p.first - (long)ed_events().size() / 2),
+ (unsigned)std::abs((long)p.second - (long)ed_events().size() / 2));
+ };
+ auto it = alg::min_of(islands, dist_to_middle);
+ // check island is in the middle third; if not, intepret it as template only
+ if (dist_to_middle(*it) > ed_events().size() / 6)
+ {
+ LOG("Fast5_Summary", info)
+ << "drop_read read_id=[" << read_id
+ << "] islands=[" << alg::os_join(
+ islands, " ",
+ [] (const std::pair< unsigned, unsigned >& p) {
+ std::ostringstream tmp;
+ tmp << "[" << p.first << "," << p.second << "]";
+ return tmp.str();
+ })
+ << "]" << std::endl;
+ return;
+ }
+ else
+ {
+ LOG("Fast5_Summary", debug)
+ << "hairpin_island [" << it->first << "," << it->second << "]" << std::endl;
+ strand_bounds[0] = 50;
+ if (islands[0].first < 100)
+ {
+ strand_bounds[0] = std::max(strand_bounds[0], islands[0].second);
+ }
+ strand_bounds[1] = it->first - 50;
+ strand_bounds[2] = it->first + 50;
+ strand_bounds[3] = ed_events().size() - 50;
+ if (islands[islands.size() - 1].second > ed_events().size() - 100)
+ {
+ strand_bounds[3] = std::min(strand_bounds[3], islands[islands.size() - 1].first);
+ }
+ }
+ } // detect_strands()
+
+ // crude filtering of eventdetection events
+ static bool filter_ed_event(const fast5::EventDetection_Event_Entry& e, Float_Type abasic_level)
+ {
+ if (e.mean >= abasic_level)
+ {
+ return false;
+ }
+ if (e.stdv > 4.0)
+ {
+ return false;
+ }
+ return true;
+ } // filter_ed_event()
+}; // struct Fast5_Summary
+
+#endif
diff --git a/src/nanocall/Forward_Backward.hpp b/src/nanocall/Forward_Backward.hpp
new file mode 100644
index 0000000..4cf7e89
--- /dev/null
+++ b/src/nanocall/Forward_Backward.hpp
@@ -0,0 +1,156 @@
+#ifndef __FORWARD_BACKWARD_HPP
+#define __FORWARD_BACKWARD_HPP
+
+#include <cmath>
+#include <iostream>
+#include <vector>
+#include <set>
+
+#include "Pore_Model.hpp"
+#include "State_Transitions.hpp"
+#include "logsumset.hpp"
+#include "logger.hpp"
+
+template < typename Float_Type, unsigned Kmer_Size = 6 >
+class Forward_Backward
+{
+public:
+ typedef Kmer< Kmer_Size > Kmer_Type;
+ typedef Pore_Model< Float_Type, Kmer_Size > Pore_Model_Type;
+ typedef State_Transitions< Float_Type, Kmer_Size > State_Transitions_Type;
+ typedef Event< Float_Type, Kmer_Size > Event_Type;
+ typedef Event_Sequence< Float_Type, Kmer_Size > Event_Sequence_Type;
+ typedef logsum::logsumset< Float_Type > LogSumSet_Type;
+
+ struct Matrix_Entry
+ {
+ Float_Type alpha; // := Pr[ E_1 ... E_i, S_i = j ]
+ Float_Type beta; // := Pr[ E_{i+1} ... E_n | S_i = j ]
+ }; // struct Matrix_Entry
+
+ static const unsigned n_states = Pore_Model_Type::n_states;
+
+ void clear() { _m.clear(); }
+ unsigned n_events() const { return _m.size() / n_states; }
+
+ // i: event index
+ // j: state/kmer index
+ const Matrix_Entry& cell(unsigned i, unsigned j) const { return _m[i * n_states + j]; }
+ Matrix_Entry& cell(unsigned i, unsigned j) { return _m[i * n_states + j]; }
+
+ Float_Type log_posterior(unsigned i, unsigned j) const { return cell(i, j).alpha + cell(i, j).beta - _log_pr_data; }
+ Float_Type log_pr_data() const { return _log_pr_data; }
+
+ static unsigned& n_threads() { static unsigned _n_threads = 1; return _n_threads; }
+
+ void fill(const Pore_Model_Type& pm,
+ const State_Transitions_Type& st,
+ const Event_Sequence_Type& ev)
+ {
+ clear();
+ unsigned n_events = ev.size();
+ _m.resize(n_states * n_events);
+ Float_Type log_n_states = std::log(static_cast< Float_Type >(n_states));
+ LogSumSet_Type s(false);
+ //
+ // forward: alpha, i == 0
+ //
+ {
+ unsigned i = 0;
+ LOG("Forward_Backward", debug1) << "forward: i=" << i << std::endl;
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ cell(i, j).alpha = pm.log_pr_corrected_emission(j, ev[0]) - log_n_states;
+ LOG("Forward_Backward", debug2)
+ << "i=" << i << " j=" << j << " kmer_j=" << Kmer_Type::to_string(j)
+ << " alpha=" << cell(i, j).alpha << std::endl;
+ }
+ }
+ //
+ // forward: alpha, i > 0
+ //
+ for (unsigned i = 1; i < ev.size(); ++i)
+ {
+ LOG("Forward_Backward", debug1) << "forward: i=" << i << std::endl;
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ s.clear();
+ for (const auto& p : st.neighbours(j).from_v)
+ {
+ const unsigned& j_prev = p.first;
+ const Float_Type& log_pr_transition = p.second;
+ s.add(log_pr_transition + cell(i - 1, j_prev).alpha);
+ }
+ cell(i, j).alpha = pm.log_pr_corrected_emission(j, ev[i]) + s.val();
+ LOG("Forward_Backward", debug2)
+ << "i=" << i << " j=" << j << " kmer_j=" << Kmer_Type::to_string(j)
+ << " alpha=" << cell(i, j).alpha << std::endl;
+ }
+ }
+ //
+ // backward: beta, i == n-1
+ //
+ {
+ unsigned i = ev.size() - 1;
+ LOG("Forward_Backward", debug1) << "backward: i=" << i << std::endl;
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ cell(i, j).beta = 0;
+ LOG("Forward_Backward", debug2)
+ << "i=" << i << " j=" << j << " kmer_j=" << Kmer_Type::to_string(j)
+ << " beta=" << cell(i, j).beta << std::endl;
+ }
+ }
+ //
+ // backward: beta, i < n-1
+ //
+ for (unsigned ip1 = ev.size() - 1; ip1 > 0; --ip1)
+ {
+ unsigned i = ip1 - 1;
+ LOG("Forward_Backward", debug1) << "backward: i=" << i << std::endl;
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ s.clear();
+ for (const auto& p : st.neighbours(j).to_v)
+ {
+ const unsigned& j_next = p.first;
+ const Float_Type& log_pr_transition = p.second;
+ s.add(log_pr_transition + pm.log_pr_corrected_emission(j_next, ev[ip1]) + cell(ip1, j_next).beta);
+ }
+ cell(i, j).beta += s.val();
+ LOG("Forward_Backward", debug2)
+ << "i=" << i << " j=" << j << " kmer_j=" << Kmer_Type::to_string(j)
+ << " beta=" << cell(i, j).beta << std::endl;
+ }
+ }
+ //
+ // pr_data
+ //
+ s.clear();
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ s.add(cell(ev.size() - 1, j).alpha);
+ }
+ _log_pr_data = s.val();
+ }
+
+ friend std::ostream& operator << (std::ostream& os, const Forward_Backward& fwbw)
+ {
+ for (unsigned i = 0; i < fwbw.n_events(); ++i)
+ {
+ for (unsigned j = 0; j < fwbw.n_states; ++j)
+ {
+ os << i << '\t' << j << '\t'
+ << fwbw.cell(i, j).alpha << '\t'
+ << fwbw.cell(i, j).beta << std::endl;
+ }
+ }
+ return os;
+ }
+
+private:
+ std::vector< Matrix_Entry > _m;
+ Float_Type _log_pr_data;
+}; // class Forward_Backward
+
+#endif
diff --git a/src/nanocall/Forward_Backward_Custom.hpp b/src/nanocall/Forward_Backward_Custom.hpp
new file mode 100644
index 0000000..3893f58
--- /dev/null
+++ b/src/nanocall/Forward_Backward_Custom.hpp
@@ -0,0 +1,163 @@
+#ifndef __FORWARD_BACKWARD_CUSTOM_HPP
+#define __FORWARD_BACKWARD_CUSTOM_HPP
+
+#include <cmath>
+#include <iostream>
+#include <vector>
+#include <set>
+
+#include "Pore_Model.hpp"
+#include "State_Transitions.hpp"
+#include "logsumset.hpp"
+#include "logger.hpp"
+
+template < typename Float_Type, unsigned Kmer_Size = 6 >
+class Forward_Backward_Custom
+{
+public:
+ typedef Kmer< Kmer_Size > Kmer_Type;
+ typedef Pore_Model< Float_Type, Kmer_Size > Pore_Model_Type;
+ typedef State_Transitions< Float_Type, Kmer_Size > State_Transitions_Type;
+ typedef Event< Float_Type, Kmer_Size > Event_Type;
+ typedef Event_Sequence< Float_Type, Kmer_Size > Event_Sequence_Type;
+ typedef logsum::logsumset< Float_Type > LogSumSet_Type;
+
+ struct Matrix_Entry
+ {
+ Float_Type alpha; // := Pr[ S_i = j | e_1 ... e_{i-1} ]
+ Float_Type beta; // := Pr[ S_i = j | e_1 ... e_i ]
+ Float_Type gamma; // := Pr[ S_i = j | e_1 ... e_n ]
+ }; // struct Matrix_Entry
+
+ static const unsigned n_states = Pore_Model_Type::n_states;
+
+ void clear() { _m.clear(); }
+ unsigned n_events() const { return _m.size() / n_states; }
+
+ // i: event index
+ // j: state/kmer index
+ const Matrix_Entry& cell(unsigned i, unsigned j) const { return _m[i * n_states + j]; }
+ Matrix_Entry& cell(unsigned i, unsigned j) { return _m[i * n_states + j]; }
+
+ Float_Type log_posterior(unsigned i, unsigned j) const { return cell(i, j).gamma; }
+
+ static unsigned& n_threads() { static unsigned _n_threads = 1; return _n_threads; }
+
+ void fill(const Pore_Model_Type& pm,
+ const State_Transitions_Type& st,
+ const Event_Sequence_Type& ev)
+ {
+ clear();
+ unsigned n_events = ev.size();
+ _m.resize(n_states * n_events);
+ Float_Type log_n_states = std::log(static_cast< Float_Type >(n_states));
+ LogSumSet_Type s1(false);
+ LogSumSet_Type s2(false);
+ //
+ // forward: alpha, beta; i == 0
+ //
+ {
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ // alpha
+ cell(0, j).alpha = - log_n_states;
+ // beta
+ cell(0, j).beta = pm.log_pr_emission(j, ev[0]) + cell(0, j).alpha;
+ s1.add(cell(0, j).beta);
+ }
+ Float_Type denom = s1.val();
+ LOG("Forward_Backward_Custom", debug1) << "i=0 beta_denom=" << denom << std::endl;
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ cell(0, j).beta -= denom;
+ LOG("Forward_Backward_Custom", debug2)
+ << "i=0 j=" << Kmer_Type::to_string(j)
+ << " alpha=" << cell(0, j).alpha
+ << " beta=" << cell(0, j).beta << std::endl;
+ }
+ }
+ //
+ // forward: alpha, beta; i > 0
+ //
+ for (unsigned i = 1; i < ev.size(); ++i)
+ {
+ LOG("Forward_Backward_Custom", debug1) << "forward: i=" << i << std::endl;
+ s1.clear();
+ for (unsigned j = 0; j < n_states; ++j) // TODO: parallelize
+ {
+ // alpha
+ s2.clear();
+ for (const auto& p : st.neighbours(j).from_v)
+ {
+ const unsigned& j_prev = p.first;
+ const Float_Type& log_pr_transition = p.second;
+ s2.add(log_pr_transition + cell(i - 1, j_prev).beta);
+ }
+ cell(i, j).alpha = s2.val();
+ // beta
+ cell(i, j).beta = pm.log_pr_emission(j, ev[i]) + cell(i, j).alpha;
+ s1.add(cell(i, j).beta);
+ }
+ Float_Type denom = s1.val();
+ LOG("Forward_Backward_Custom", debug1) << "i=" << i << " beta_denom=" << denom << std::endl;
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ cell(i, j).beta -= denom;
+ LOG("Forward_Backward_Custom", debug2)
+ << "i=" << i << " j=" << Kmer_Type::to_string(j)
+ << " alpha=" << cell(i, j).alpha
+ << " beta=" << cell(i, j).beta << std::endl;
+ }
+ }
+ //
+ // backward, gamma; i == n-1
+ //
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ cell(n_events - 1, j).gamma = cell(n_events - 1, j).beta;
+ }
+ //
+ // backward, gamma; i < n-1
+ //
+ for (unsigned ip1 = ev.size() - 1; ip1 > 0; --ip1)
+ {
+ unsigned i = ip1 - 1;
+ LOG("Forward_Backward_Custom", debug1) << "backward: i=" << i << std::endl;
+ for (unsigned j = 0; j < n_states; ++j) // TODO: parallelize
+ {
+ cell(i, j).gamma = cell(i, j).beta;
+ s2.clear();
+ for (const auto& p : st.neighbours(j).to_v)
+ {
+ const unsigned& j_next = p.first;
+ const Float_Type& log_pr_transition = p.second;
+ s2.add(log_pr_transition + cell(ip1, j_next).gamma - cell(ip1, j_next).alpha);
+ }
+ cell(i, j).gamma += s2.val();
+ LOG("Forward_Backward_Custom", debug2)
+ << "i=" << i << " j=" << Kmer_Type::to_string(j)
+ << " gamma=" << cell(i, j).gamma << std::endl;
+ }
+ }
+ }
+
+ friend std::ostream& operator << (std::ostream& os, const Forward_Backward_Custom& fwbw)
+ {
+ for (unsigned i = 0; i < fwbw.n_events(); ++i)
+ {
+ for (unsigned j = 0; j < fwbw.n_states; ++j)
+ {
+ os << i << '\t' << j << '\t'
+ << fwbw.cell(i, j).alpha << '\t'
+ << fwbw.cell(i, j).beta << '\t'
+ << fwbw.cell(i, j).gamma << std::endl;
+ }
+ }
+ return os;
+ }
+
+private:
+ std::vector< Matrix_Entry > _m;
+}; // class Forward_Backward_Custom
+
+#endif
diff --git a/src/nanocall/Kmer.hpp b/src/nanocall/Kmer.hpp
new file mode 100644
index 0000000..3d91d43
--- /dev/null
+++ b/src/nanocall/Kmer.hpp
@@ -0,0 +1,151 @@
+#ifndef __KMER_HPP
+#define __KMER_HPP
+
+#include <array>
+#include <string>
+#include <mutex>
+
+template < unsigned Kmer_Size >
+class Kmer
+{
+public:
+ static const unsigned n_states = (1u << (2 * Kmer_Size));
+ static size_t to_int(const std::string& s)
+ {
+ static std::array< int8_t, 256 > base_to_int;
+ static bool table_initialized = false;
+ if (not table_initialized)
+ {
+ for (unsigned i = 0; i < 256; ++i)
+ {
+ base_to_int[i] = -1;
+ }
+ base_to_int['A'] = 0;
+ base_to_int['C'] = 1;
+ base_to_int['G'] = 2;
+ base_to_int['T'] = 3;
+ table_initialized = true;
+ }
+ size_t res = 0;
+ for (size_t i = 0; i < s.size(); ++i)
+ {
+ res <<= 2;
+ res += base_to_int[static_cast< unsigned >(s[i])];
+ }
+ return res;
+ }
+ static size_t to_int(const std::array< char, Kmer_Size >& a)
+ {
+ return to_int(std::string(a.begin(), a.end()));
+ }
+ static std::string to_string(size_t k)
+ {
+ static const std::string int_to_base("ACGT");
+ std::string res;
+ for (size_t j = 0; j < Kmer_Size; ++j)
+ {
+ res += int_to_base[(k >> (2 * (Kmer_Size - j - 1))) & 0x3];
+ }
+ return res;
+ }
+ static unsigned min_skip(unsigned k1, unsigned k2)
+ {
+ if (k1 == k2)
+ {
+ return 0;
+ }
+ else
+ {
+ for (unsigned k = Kmer_Size - 1; k > 0; --k)
+ {
+ if ((k1 & ((1u << (2 * k)) - 1)) == (k2 >> (2 * (Kmer_Size - k))))
+ {
+ return Kmer_Size - k;
+ }
+ }
+ return Kmer_Size;
+ }
+ }
+ static unsigned prefix(unsigned i, unsigned k)
+ {
+ return i >> (2 * (Kmer_Size - k));
+ }
+ static unsigned suffix(unsigned i, unsigned k)
+ {
+ return i & ((1u << (2 * k)) - 1);
+ }
+
+ /*
+ * Precompute, for every kmer i, the maximum k such that suffix(i, k) == prefix(i, k)
+ */
+ static unsigned max_self_overlap(unsigned i)
+ {
+ assert(i < n_states);
+ std::array< unsigned, n_states > _max_self_overlap;
+ bool _inited = false;
+ if (not _inited)
+ {
+ static std::mutex _mutex;
+ {
+ std::lock_guard< std::mutex > _lock(_mutex);
+ if (not _inited) // recheck
+ {
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ _max_self_overlap[i] = 0;
+ for (unsigned k = Kmer_Size - 1; k >= 1; --k)
+ {
+ if (suffix(i, k) == prefix(i, k))
+ {
+ _max_self_overlap[i] = k;
+ break;
+ }
+ }
+ }
+ _inited = true;
+ }
+ }
+ }
+ return _max_self_overlap[i];
+ }
+
+ /*
+ * Precompute neighbours at distance 1 and 2.
+ */
+ static const std::vector< unsigned >& neighbour_list(unsigned i, unsigned d)
+ {
+ assert(i < n_states);
+ assert(d == 1 or d == 2);
+ static std::array< std::array< std::vector< unsigned >, 2 >, 4096 > _neighbour_list;
+ static bool _inited = false;
+ if (not _inited)
+ {
+ static std::mutex _mutex;
+ {
+ std::lock_guard< std::mutex > _lock(_mutex);
+ if (not _inited) // recheck
+ {
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ _neighbour_list[i][0].clear();
+ _neighbour_list[i][1].clear();
+ for (unsigned b1 = 0; b1 < 4; ++b1)
+ {
+ unsigned i1 = (suffix(i, Kmer_Size - 1) << 2) + b1;
+ _neighbour_list[i][0].push_back(i1);
+ for (unsigned b2 = 0; b2 < 4; ++b2)
+ {
+ unsigned i2 = (suffix(i1, Kmer_Size - 1) << 2) + b2;
+ _neighbour_list[i][1].push_back(i2);
+ }
+ }
+ }
+ _inited = true;
+ }
+ }
+ }
+ return _neighbour_list[i][d - 1];
+ }
+}; // class Kmer
+
+#endif
diff --git a/src/nanocall/Parameter_Trainer.hpp b/src/nanocall/Parameter_Trainer.hpp
new file mode 100644
index 0000000..8afde3f
--- /dev/null
+++ b/src/nanocall/Parameter_Trainer.hpp
@@ -0,0 +1,570 @@
+#ifndef __PARAMETER_TRAINER
+#define __PARAMETER_TRAINER
+
+#include <array>
+#include <vector>
+#include <map>
+
+#include "global_assert.hpp"
+#include "Pore_Model.hpp"
+#include "State_Transitions.hpp"
+#include "Forward_Backward.hpp"
+#include "logsumset.hpp"
+#include "logger.hpp"
+
+template < typename Float_Type, unsigned Kmer_Size = 6 >
+struct Parameter_Trainer
+{
+ typedef Kmer< Kmer_Size > Kmer_Type;
+ typedef Pore_Model< Float_Type, Kmer_Size > Pore_Model_Type;
+ typedef Pore_Model_Parameters< Float_Type > Pore_Model_Parameters_Type;
+ typedef State_Transitions< Float_Type, Kmer_Size > State_Transitions_Type;
+ typedef State_Transition_Parameters< Float_Type > State_Transition_Parameters_Type;
+ typedef Event< Float_Type, Kmer_Size > Event_Type;
+ typedef Event_Sequence< Float_Type, Kmer_Size > Event_Sequence_Type;
+ typedef Forward_Backward< Float_Type, Kmer_Size > Forward_Backward_Type;
+ typedef logsum::logsumset< Float_Type > LogSumSet_Type;
+
+ static const unsigned n_states = Pore_Model_Type::n_states;
+
+ static void init()
+ {
+ // pick states i s.t. i has self-overlap 0,
+ // and all its 1-step neighbours have self-overlap <=1
+ st_train_kmers().clear();
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ if (Kmer_Type::max_self_overlap(i) > 0)
+ {
+ continue;
+ }
+ bool all_good = true;
+ for (unsigned b1 = 0; b1 < 4; ++b1)
+ {
+ unsigned j = (Kmer_Type::suffix(i, Kmer_Size - 1) << 2) + b1;
+ if (Kmer_Type::max_self_overlap(j) > 1)
+ {
+ all_good = false;
+ break;
+ }
+ }
+ if (all_good)
+ {
+ st_train_kmers().push_back(i);
+ }
+ }
+ LOG(info) << "using [" << st_train_kmers().size() << "] states for state trainsition training" << std::endl;
+ }
+
+ static std::vector< unsigned >& st_train_kmers()
+ {
+ static std::vector< unsigned > _st_train_kmers;
+ return _st_train_kmers;
+ }
+
+ /**
+ * Struct used for training rounds.
+ * @event_seq_ptr_v Vector of pairs, first: an event sequence, second: strand from which it comes
+ * @model_ptr_v Pointers to unscaled pore models (per strand)
+ * @default_transitions_ptr Default state transitions
+ * @pm_params_ptr Pore model scaling parameters (common to both strands)
+ * @st_params_ptr_v State transition parameters (per strand)
+ */
+ struct Train_Data
+ {
+ // input
+ std::vector< std::pair< const Event_Sequence_Type*, unsigned > > event_seq_ptr_v;
+ std::array< const Pore_Model_Type*, 2 > model_ptr_v;
+ const State_Transitions_Type* default_transitions_ptr;
+ const Pore_Model_Parameters_Type* pm_params_ptr;
+ std::array< const State_Transition_Parameters_Type*, 2 > st_params_ptr_v;
+ // output
+ std::array< Pore_Model_Type, 2 > scaled_model_v;
+ std::array< State_Transitions_Type, 2 > custom_transitions_v;
+ std::array< const State_Transitions_Type*, 2 > transitions_ptr_v;
+ std::vector< Event_Sequence_Type > corrected_event_seq_v;
+ std::vector< Forward_Backward_Type > fwbw_v;
+ Float_Type fit;
+ };
+
+ /**
+ * Fill training data for one training round.
+ */
+ static void fill_train_data(Train_Data& data)
+ {
+ // compute scaled pore models
+ data.scaled_model_v[0].clear();
+ data.scaled_model_v[1].clear();
+ std::array< bool, 2 > init_scaled_models = {{ false, false }};
+ for (const auto& p : data.event_seq_ptr_v)
+ {
+ ASSERT(p.second < 2);
+ if (init_scaled_models[p.second]) continue;
+ ASSERT(data.model_ptr_v[p.second]);
+ ASSERT(data.pm_params_ptr);
+ data.scaled_model_v[p.second] = *data.model_ptr_v[p.second];
+ data.scaled_model_v[p.second].scale(*data.pm_params_ptr);
+ init_scaled_models[p.second] = true;
+ }
+ // compute custom state transitions
+ data.custom_transitions_v[0].clear();
+ data.custom_transitions_v[1].clear();
+ std::array< bool, 2 > init_transitions = {{ false, false }};
+ for (const auto& p : data.event_seq_ptr_v)
+ {
+ if (init_transitions[p.second]) continue;
+ ASSERT(data.st_params_ptr_v[p.second]);
+ if (not data.st_params_ptr_v[p.second]->is_default())
+ {
+ data.custom_transitions_v[p.second].compute_transitions_fast(*data.st_params_ptr_v[p.second]);
+ data.transitions_ptr_v[p.second] = &data.custom_transitions_v[p.second];
+ }
+ else
+ {
+ data.transitions_ptr_v[p.second] = data.default_transitions_ptr;
+ }
+ init_transitions[p.second] = true;
+ }
+ // compute drift-corrected event sequences
+ unsigned n_event_seqs = data.event_seq_ptr_v.size();
+ data.corrected_event_seq_v.clear();
+ data.corrected_event_seq_v.reserve(n_event_seqs);
+ data.fwbw_v.clear();
+ data.fwbw_v.reserve(n_event_seqs);
+ data.fit = 0.0;
+ for (unsigned k = 0; k < n_event_seqs; ++k)
+ {
+ unsigned st = data.event_seq_ptr_v[k].second;
+ ASSERT(init_scaled_models[st]);
+ ASSERT(init_transitions[st]);
+ // first, copy events
+ data.corrected_event_seq_v.emplace_back(*data.event_seq_ptr_v[k].first);
+ // then, apply drift correction
+ data.corrected_event_seq_v.back().apply_drift_correction(data.pm_params_ptr->drift);
+ // finally, run fwbw
+ data.fwbw_v.emplace_back();
+ data.fwbw_v.back().fill(
+ data.scaled_model_v[st], *data.transitions_ptr_v[st], data.corrected_event_seq_v.back());
+ data.fit += data.fwbw_v.back().log_pr_data();
+ }
+#ifdef DUMP_TRAINING_DATA
+ for (unsigned k = 0; k < n_event_seqs; ++k)
+ {
+ unsigned st = data.event_seq_ptr_v[k].second;
+ unsigned n_events = data.event_seq_ptr_v[k].first->size();
+ std::ostringstream k_sstr;
+ k_sstr << k;
+ std::ofstream ofs;
+ ofs.open(std::string("emissions.") + k_sstr.str() + ".tab");
+ for (unsigned i = 0; i < n_events; ++i)
+ {
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ if (j > 0) ofs << '\t';
+ ofs << data.scaled_model_v[st].log_pr_corrected_emission(j, data.corrected_event_seq_v[k][i]);
+ }
+ ofs << std::endl;
+ }
+ ofs.close();
+ ofs.open(std::string("transitions.") + k_sstr.str() + ".tab");
+ for (unsigned j1 = 0; j1 < n_states; ++j1)
+ {
+ std::map< unsigned, Float_Type > neighbour_m;
+ for (const auto& p : data.transitions_ptr_v[st]->neighbours(j1).to_v)
+ {
+ neighbour_m[p.first] = p.second;
+ }
+ for (unsigned j2 = 0; j2 < n_states; ++j2)
+ {
+ if (j2 > 0) ofs << '\t';
+ if (neighbour_m.count(j2))
+ {
+ ofs << neighbour_m.at(j2);
+ }
+ else
+ {
+ ofs << -1000.0;
+ }
+ }
+ ofs << std::endl;
+ }
+ ofs.close();
+ ofs.open(std::string("fw.") + k_sstr.str() + ".tab");
+ for (unsigned i = 0; i < n_events; ++i)
+ {
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ if (j > 0) ofs << '\t';
+ ofs << data.fwbw_v[k].cell(i, j).alpha;
+ }
+ ofs << std::endl;
+ }
+ ofs.close();
+ ofs.open(std::string("bw.") + k_sstr.str() + ".tab");
+ for (unsigned i = 0; i < n_events; ++i)
+ {
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ if (j > 0) ofs << '\t';
+ ofs << data.fwbw_v[k].cell(i, j).beta;
+ }
+ ofs << std::endl;
+ }
+ }
+ abort();
+#endif
+ }
+
+ /**
+ * Train pm_params on training data.
+ * @data Training data, as filled by fill_train_data.
+ * @new_pm_params Destination for new params.
+ * @done Bool; if true, training failed, and no rounds are possible because of a singularity.
+ */
+ static void train_pm_params(const Train_Data& data, Pore_Model_Parameters_Type& new_pm_params, bool& done)
+ {
+ done = false;
+ unsigned n_event_seqs = data.event_seq_ptr_v.size();
+ unsigned total_n_events = 0;
+ ASSERT(data.pm_params_ptr);
+ //
+ // compute the scaling matrices in normal space (not logspace!)
+ // against unscaled pm & uncorrected events
+ //
+ auto& a_hat = new_pm_params.shift;
+ auto& b_hat = new_pm_params.scale;
+ auto& c_hat = new_pm_params.drift;
+ auto& d_hat = new_pm_params.var;
+ auto& v_hat = new_pm_params.scale_sd;
+ auto& u_hat = new_pm_params.var_sd;
+ std::array< std::array< double, 3 >, 3 > A = {{ {{ 0.0, 0.0, 0.0 }},
+ {{ 0.0, 0.0, 0.0 }},
+ {{ 0.0, 0.0, 0.0 }} }};
+ std::array< double, 3 > B = {{ 0.0, 0.0, 0.0 }};
+ double D = 0.0; // = \sum_i x^2_i s_{i,0} (used for var)
+ double V_numer = 0.0; // = \sum_i y_i \sum_j p_{i,j} \lambda_j / \eta^2_j (for scale_sd)
+ double V_denom = 0.0; // = \sum_i \sum_j p_{i,j} \lambda_j / \eta_j (for scale_sd)
+ double U_pos = 0.0; // = \sum_i (1/y_i) \sum_j p_{i,j} \lambda_j (for var_sd)
+ for (unsigned k = 0; k < n_event_seqs; ++k)
+ {
+ unsigned st = data.event_seq_ptr_v.at(k).second;
+ ASSERT(st < 2);
+ const Event_Sequence_Type& events = *data.event_seq_ptr_v[k].first;
+ unsigned n_events = events.size();
+ total_n_events += n_events;
+ const Pore_Model_Type& pm = *data.model_ptr_v[st];
+ const Forward_Backward_Type& fwbw = data.fwbw_v.at(k);
+ for (unsigned i = 0; i < n_events; ++i)
+ {
+ Float_Type x_i = events[i].mean;
+ Float_Type y_i = events[i].stdv;
+ Float_Type t_i = events[i].start;
+ LOG(debug1)
+ << "outter_loop k=" << k << " i=" << i
+ << " x_i=" << x_i
+ << " t_i=" << t_i << std::endl;
+ // \sum_j p_{i,j} \mu^*_j / \simga^2_j
+ std::array< float, 3 > s = {{ 0.0, 0.0, 0.0 }};
+ // \sum_j p_{i,j} \lambda_j / \eta^*_j
+ std::array< float, 3 > l = {{ 0.0, 0.0, 0.0 }};
+ for (unsigned j = 0; j < Pore_Model_Type::n_states; ++j)
+ {
+ Float_Type p_ij = std::exp(fwbw.log_posterior(i, j));
+ Float_Type term_s0 = p_ij / (pm.state(j).level_stdv * pm.state(j).level_stdv);
+ Float_Type term_s1 = term_s0 * pm.state(j).level_mean;
+ Float_Type term_s2 = term_s1 * pm.state(j).level_mean;
+ Float_Type term_l0 = p_ij * pm.state(j).sd_lambda;
+ Float_Type term_l1 = term_l0 / pm.state(j).sd_mean;
+ Float_Type term_l2 = term_l1 / pm.state(j).sd_mean;
+ LOG(debug2)
+ << "inner_loop k=" << k << " i=" << i << " j=" << j << " p_ij=" << p_ij
+ << " term_s0=" << term_s0 << " term_s1=" << term_s1 << " term_s2=" << term_s2
+ << " term_l0=" << term_l0 << " term_l1=" << term_l1 << " term_l2=" << term_l2
+ << std::endl;
+ s[0] += term_s0;
+ s[1] += term_s1;
+ s[2] += term_s2;
+ l[0] += term_l0;
+ l[1] += term_l1;
+ l[2] += term_l2;
+ } // for j
+ A[0][0] += s[0];
+ A[0][1] += s[1];
+ A[0][2] += s[0] * t_i;
+ A[1][1] += s[2];
+ A[1][2] += s[1] * t_i;
+ A[2][2] += s[0] * t_i * t_i;
+ B[0] += s[0] * x_i;
+ B[1] += s[1] * x_i;
+ B[2] += s[0] * x_i * t_i;
+ D += s[0] * x_i * x_i;
+ V_numer += l[2] * y_i;
+ V_denom += l[1];
+ U_pos += l[0] / y_i;
+ } // for i
+ } // for k
+ A[1][0] = A[0][1];
+ A[2][0] = A[0][2];
+ A[2][1] = A[1][2];
+ auto A_copy = A;
+ auto B_copy = B;
+ // compute scaling vector used for scaled partial pivoting
+ std::array< double, 3 > C;
+ for (unsigned i = 0; i < 3; ++i)
+ {
+ C[i] = alg::max_value_of(A[i]); // no need for abs(), as A>0
+ }
+ LOG(debug1)
+ << "A={{" << A[0][0] << ", " << A[0][1] << ", " << A[0][2]
+ << "}, {" << A[1][0] << ", " << A[1][1] << ", " << A[1][2]
+ << "}, {" << A[2][0] << ", " << A[2][1] << ", " << A[2][2]
+ << "}} B={" << B[0] << ", " << B[1] << ", " << B[2]
+ << "} C={" << C[0] << ", " << C[1] << ", " << C[2] << "}" << std::endl;
+ //
+ // solve A * X = B using Gaussian elimination with partial pivoting
+ //
+ for (unsigned i = 0; i < 3; ++i)
+ {
+ unsigned p = i;
+ double p_val = std::abs(A[i][i]) / C[p];
+ for (unsigned i2 = i + 1; i2 < 3; ++i2)
+ {
+ double i2_val = std::abs(A[i2][i]) / C[i2];
+ if (i2_val > p_val)
+ {
+ p = i2;
+ p_val = i2_val;
+ }
+ }
+ LOG(debug1)
+ << "gaussian_elimination i=" << i << " p=" << p << " p_val=" << p_val << std::endl;
+ // if the pivot is too small, consider matrix singular, and give up
+ if (p_val < 1e-7)
+ {
+ done = true;
+ new_pm_params = *data.pm_params_ptr;
+ return;
+ }
+ // if necessary, interchange rows i & p
+ if (p > i)
+ {
+ std::swap(A[i], A[p]);
+ std::swap(B[i], B[p]);
+ std::swap(C[i], C[p]);
+ }
+ // eliminate variable i from the last i-1 equations
+ for (p = i + 1; p < 3; ++p)
+ {
+ double m = A[p][i] / A[i][i];
+ A[p][i] = 0;
+ for (unsigned j = i + 1; j < 3; ++j)
+ {
+ A[p][j] -= m * A[i][j];
+ }
+ B[p] -= m * B[i];
+ }
+ LOG(debug1)
+ << "gaussian_elimination i=" << i
+ << " A={{" << A[0][0] << ", " << A[0][1] << ", " << A[0][2]
+ << "}, {" << A[1][0] << ", " << A[1][1] << ", " << A[1][2]
+ << "}, {" << A[2][0] << ", " << A[2][1] << ", " << A[2][2]
+ << "}} B={" << B[0] << ", " << B[1] << ", " << B[2]
+ << "} C={" << C[0] << ", " << C[1] << ", " << C[2] << "}" << std::endl;
+ }
+ // solve the upper triangular system by hand, storing the solutions as the new parameters
+ c_hat = B[2] / A[2][2];
+ b_hat = (B[1] - A[1][2] * c_hat) / A[1][1];
+ a_hat = (B[0] - A[0][1] * b_hat - A[0][2] * c_hat) / A[0][0];
+ LOG(debug1)
+ << "update_step a=" << a_hat << " b=" << b_hat << " c=" << c_hat << std::endl;
+#ifndef NDEBUG
+ // sanity check
+ for (unsigned i = 0; i < 3; ++i)
+ {
+ double x = (A_copy[i][0] * a_hat
+ + A_copy[i][1] * b_hat
+ + A_copy[i][2] * c_hat);
+ ASSERT((x - B_copy[i])/std::max(x, B_copy[i]) < 1e-3);
+ }
+#endif
+ //
+ // update var
+ //
+ double d_numer = (D
+ + a_hat * a_hat * A_copy[0][0]
+ + b_hat * b_hat * A_copy[1][1]
+ + c_hat * c_hat * A_copy[2][2]
+ + 2.0 * a_hat * b_hat * A_copy[0][1]
+ + 2.0 * a_hat * c_hat * A_copy[0][2]
+ + 2.0 * b_hat * c_hat * A_copy[1][2]
+ - 2.0 * (a_hat * B_copy[0]
+ + b_hat * B_copy[1]
+ + c_hat * B_copy[2])
+ );
+ d_hat = std::sqrt(d_numer / (double)total_n_events);
+ LOG(debug1) << "update_step d=" << d_hat << std::endl;
+ //
+ // update scale_sd
+ //
+ v_hat = V_numer / V_denom;
+ //
+ // update var_sd
+ //
+ u_hat = (double)total_n_events / (U_pos - V_denom / v_hat);
+ }
+
+ /**
+ * Train st_params on training data.
+ * @data Training data, as filled by fill_train_data.
+ * @new_st_params Destination for new st params.
+ */
+ static void train_st_params(const Train_Data& data,
+ std::array< State_Transition_Parameters_Type, 2 >& new_st_params)
+ {
+ unsigned n_event_seqs = data.event_seq_ptr_v.size();
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ ASSERT(data.st_params_ptr_v[st]);
+ LogSumSet_Type s_p_stay_num(false);
+ LogSumSet_Type s_p_skip_num(false);
+ LogSumSet_Type s_denom(false);
+ Float_Type log_p_stay = std::log(data.st_params_ptr_v[st]->p_stay);
+ Float_Type log_p_step_4 = std::log(1.0 - data.st_params_ptr_v[st]->p_stay - data.st_params_ptr_v[st]->p_skip) - std::log(4.0);
+ for (unsigned k = 0; k < n_event_seqs; ++k)
+ {
+ if (data.event_seq_ptr_v[k].second != st) continue;
+ const Pore_Model_Type& scaled_pm = data.scaled_model_v[st];
+ const Event_Sequence_Type& corrected_events = data.corrected_event_seq_v.at(k);
+ unsigned n_events = corrected_events.size();
+ const Forward_Backward_Type& fwbw = data.fwbw_v.at(k);
+ //
+ // P[S_i = j1, S_{i+1} = j2]
+ //
+ auto log_joint_prob = [&] (unsigned i, unsigned j1, unsigned j2, Float_Type log_p_trans) {
+ Float_Type p = fwbw.cell(i, j1).alpha
+ + log_p_trans
+ + scaled_pm.log_pr_corrected_emission(j2, corrected_events[i + 1])
+ + fwbw.cell(i + 1, j2).beta
+ - fwbw.log_pr_data();
+ LOG(debug2) << "step_prob k=" << k
+ << " i=" << i
+ << " j1=" << Kmer_Type::to_string(j1)
+ << " j2=" << Kmer_Type::to_string(j2)
+ << " log_p_trans=" << log_p_trans
+ << " res=" << p << std::endl;
+ return p;
+ };
+
+ for (unsigned i = 0; i < n_events - 1; ++i)
+ {
+ for (auto j1 : st_train_kmers())
+ {
+ // Pr[ S_i = j1 ]
+ Float_Type log_p_j1 = fwbw.log_posterior(i, j1);
+ s_denom.add(log_p_j1);
+ // Pr[ S_i = j1, S_{i+1} = j1 ]
+ Float_Type log_p_j1_j1 = log_joint_prob(i, j1, j1, log_p_stay);
+ if (log_p_j1_j1 > log_p_j1)
+ {
+ if (log_p_j1_j1 > log_p_j1 + std::max(std::abs(log_p_j1), 1.0f) * 1.0e-3)
+ {
+ LOG(warning) << "numerical error log_p_j1 [" << log_p_j1
+ << "] log_p_j1_j1 [" << log_p_j1_j1 << "]" << std::endl;
+ }
+ log_p_j1_j1 = log_p_j1;
+ }
+ s_p_stay_num.add(log_p_j1_j1);
+ // Pr[ S_i = j1, dist(j1,S_{i+1}) > 1 ]
+ Float_Type log_p_j1_d01;
+ {
+ LogSumSet_Type s2(false);
+ s2.add(log_p_j1_j1);
+ for (auto j2 : Kmer_Type::neighbour_list(j1, 1))
+ {
+ // transition prob j1 to j2 is (p_step / 4)
+ s2.add(log_joint_prob(i, j1, j2, log_p_step_4));
+ }
+ log_p_j1_d01 = s2.val();
+ }
+ if (log_p_j1_d01 > log_p_j1)
+ {
+ if (log_p_j1_d01 > log_p_j1 + std::max(std::abs(log_p_j1), 1.0f) * 1.0e-3)
+ {
+ LOG(warning) << "numerical error log_p_j1 [" << log_p_j1
+ << "] log_p_j1_d01 [" << log_p_j1_d01 << "]" << std::endl;
+ }
+ log_p_j1_d01 = log_p_j1;
+ }
+ Float_Type p_j1_d2 = std::exp(log_p_j1) - std::exp(log_p_j1_d01);
+ s_p_skip_num.add(std::log(p_j1_d2));
+ } // for j1
+ } // for i
+ } // for k
+ new_st_params[st].p_stay = std::exp(s_p_stay_num.val() - s_denom.val());
+ new_st_params[st].p_skip = std::exp(s_p_skip_num.val() - s_denom.val());
+ if (new_st_params[st].p_stay < .05 or new_st_params[st].p_stay > .4
+ or new_st_params[st].p_skip < .05 or new_st_params[st].p_skip > .4)
+ {
+ State_Transition_Parameters_Type alt_st_params;
+ alt_st_params.p_stay = std::max(new_st_params[st].p_stay, .05f);
+ alt_st_params.p_stay = std::min(alt_st_params.p_stay, .4f);
+ alt_st_params.p_skip = std::max(new_st_params[st].p_skip, .05f);
+ alt_st_params.p_skip = std::min(alt_st_params.p_skip, .4f);
+ LOG(warning) << "unusual state transition parameters " << new_st_params[st]
+ << " for strand [" << st
+ << "] resetting them to " << alt_st_params << std::endl;
+ std::swap(alt_st_params, new_st_params[st]);
+ }
+ } // for st
+ } // train_st_params()
+
+ /**
+ * Perform one training round.
+ * @new_pm_params Destination for trained pm params (common to both strands)
+ * @new_st_params Destination for trained st params (per strand)
+ * @fit Destination for pr_data using crt params
+ * @done Bool; set to true if no more training rounds can be performed due to singularity.
+ */
+ static void train_one_round(
+ const std::vector< std::pair< const Event_Sequence_Type*, unsigned > >& event_seq_ptrs,
+ const std::array< const Pore_Model_Type*, 2 >& model_ptrs,
+ const State_Transitions_Type& default_transitions,
+ const Pore_Model_Parameters_Type& crt_pm_params,
+ const std::array< State_Transition_Parameters_Type, 2 >& crt_st_params,
+ Pore_Model_Parameters_Type& new_pm_params,
+ std::array< State_Transition_Parameters_Type, 2 >& new_st_params,
+ Float_Type& fit,
+ bool& done,
+ bool train_scaling,
+ bool train_transitions)
+ {
+ // initialize training data
+ Train_Data data;
+ data.event_seq_ptr_v = event_seq_ptrs;
+ data.model_ptr_v = model_ptrs;
+ data.default_transitions_ptr = &default_transitions;
+ data.pm_params_ptr = &crt_pm_params;
+ data.st_params_ptr_v = {{ &crt_st_params[0], &crt_st_params[1] }};
+ // fill the training data
+ fill_train_data(data);
+ fit = data.fit;
+ if (train_scaling)
+ {
+ // train pm params
+ train_pm_params(data, new_pm_params, done);
+ if (done)
+ {
+ new_st_params = crt_st_params;
+ return;
+ }
+ }
+ if (train_transitions)
+ {
+ // train st params
+ train_st_params(data, new_st_params);
+ }
+ } // train_one_round
+
+}; // class Parameter_Trainer
+
+#endif
diff --git a/src/nanocall/Pore_Model.hpp b/src/nanocall/Pore_Model.hpp
new file mode 100644
index 0000000..5f22d9f
--- /dev/null
+++ b/src/nanocall/Pore_Model.hpp
@@ -0,0 +1,319 @@
+//---------------------------------------------------------
+// Copyright 2015 Ontario Institute for Cancer Research
+// Written by Jared Simpson (jared.simpson at oicr.on.ca)
+//---------------------------------------------------------
+//
+// nanopolish_poremodel -- Representation of the Oxford
+// Nanopore sequencing model, as described in a FAST5 file
+//
+#ifndef __POREMODEL_HPP
+#define __POREMODEL_HPP
+
+#include <cassert>
+#include <cmath>
+#include <iomanip>
+#include <iostream>
+#include <map>
+#include <string>
+
+#include "Kmer.hpp"
+#include "Event.hpp"
+#include "fast5.hpp"
+#include "alg.hpp"
+
+template < typename Float_Type >
+inline Float_Type log_normal_pdf(Float_Type x, Float_Type mean, Float_Type stdv, Float_Type log_stdv)
+{
+ // From SO: http://stackoverflow.com/questions/10847007/using-the-gaussian-probability-density-function-in-c
+ static const Float_Type log_2pi = std::log(2.0 * M_PI);
+ Float_Type a = (x - mean) / stdv;
+ return - log_stdv - (log_2pi + a * a) / static_cast< Float_Type >(2.0);
+}
+
+template < typename Float_Type >
+inline Float_Type log_invgauss_pdf(Float_Type x, Float_Type log_x,
+ Float_Type mu, Float_Type lambda, Float_Type log_lambda)
+{
+ static const Float_Type log_2pi = std::log(2.0 * M_PI);
+ Float_Type a = (x - mu) / mu;
+ return (log_lambda - log_2pi - static_cast< Float_Type >(3.0) * log_x - lambda * a * a / x) / static_cast< Float_Type >(2.0);
+}
+
+template < typename Float_Type >
+struct Pore_Model_Parameters
+{
+ Pore_Model_Parameters() : scale(1.0), shift(0.0), drift(0.0), var(1.0), scale_sd(1.0), var_sd(1.0) {}
+
+ Float_Type scale;
+ Float_Type shift;
+ Float_Type drift;
+ Float_Type var;
+ Float_Type scale_sd;
+ Float_Type var_sd;
+
+ void load_from_fast5(const fast5::File& f, bool strand)
+ {
+ assert(f.have_basecall_model(strand));
+ auto m_p = f.get_basecall_model_params(strand);
+ scale = m_p.scale;
+ shift = m_p.shift;
+ drift = m_p.drift;
+ var = m_p.var;
+ scale_sd = m_p.scale_sd;
+ var_sd = m_p.var_sd;
+ }
+
+ friend std::ostream& operator << (std::ostream& os, const Pore_Model_Parameters& p)
+ {
+ os << "[scale=" << p.scale << " shift=" << p.shift << " drift=" << p.drift
+ << " var=" << p.var << " scale_sd=" << p.scale_sd << " var_sd=" << p.var_sd << "]";
+ return os;
+ }
+ void write_tsv(std::ostream& os) const
+ {
+ os << std::fixed << std::setprecision(5)
+ << scale << '\t' << shift << '\t' << drift << '\t' << var << '\t' << scale_sd << '\t' << var_sd;
+ }
+}; // struct Pore_Model_Parameters
+
+template < typename Float_Type, unsigned Kmer_Size >
+struct Pore_Model_State
+{
+ typedef Event< Float_Type, Kmer_Size > Event_Type;
+ typedef Pore_Model_Parameters< Float_Type > Pore_Model_Parameters_Type;
+
+ Float_Type level_mean;
+ Float_Type level_stdv;
+ Float_Type sd_mean;
+ Float_Type sd_stdv;
+ Float_Type sd_lambda;
+
+ Float_Type log_level_mean;
+ Float_Type log_level_stdv;
+ Float_Type log_sd_mean;
+ Float_Type log_sd_stdv;
+ Float_Type log_sd_lambda;
+
+ std::array< char, Kmer_Size > kmer;
+
+ Pore_Model_State& operator = (const fast5::Model_Entry& e)
+ {
+ level_mean = e.level_mean;
+ level_stdv = e.level_stdv;
+ sd_mean = e.sd_mean;
+ sd_stdv = e.sd_stdv;
+ std::copy_n(e.kmer.begin(), Kmer_Size, kmer.begin());
+ update_sd_lambda();
+ update_logs();
+ return *this;
+ }
+
+ // update sd_lambda based on sd_mean & sd_stdv
+ void update_sd_lambda() { sd_lambda = pow(sd_mean, 3.0) / pow(sd_stdv, 2.0); }
+
+ // update sd_stdv based on sd_mean & sd_lambda
+ void update_sd_stdv() { sd_stdv = pow(pow(sd_mean, 3.0) / sd_lambda, .5); }
+
+ // update logs
+ void update_logs()
+ {
+ log_level_mean = std::log(level_mean);
+ log_level_stdv = std::log(level_stdv);
+ log_sd_mean = std::log(sd_mean);
+ log_sd_lambda = std::log(sd_lambda);
+ }
+
+ void scale(const Pore_Model_Parameters_Type& params, const Pore_Model_Parameters_Type& log_params)
+ {
+ // these functions are provided by ONT
+ level_mean = level_mean * params.scale + params.shift;
+ level_stdv = level_stdv * params.var;
+ sd_mean = sd_mean * params.scale_sd;
+ sd_lambda = sd_lambda * params.var_sd;
+ update_sd_stdv();
+ log_level_mean = std::log(level_mean);
+ log_level_stdv += log_params.var;
+ log_sd_mean += log_params.scale_sd;
+ log_sd_lambda += log_params.var_sd;
+ }
+
+ Float_Type log_pr_emission(const Event_Type& e) const
+ {
+ return (log_normal_pdf< Float_Type >(e.mean, level_mean, level_stdv, log_level_stdv)
+ + log_invgauss_pdf< Float_Type >(e.stdv, e.log_stdv, sd_mean, sd_lambda, log_sd_lambda));
+ }
+ Float_Type log_pr_corrected_emission(const Event_Type& e) const
+ {
+ return (log_normal_pdf< Float_Type >(e.corrected_mean, level_mean, level_stdv, log_level_stdv)
+ + log_invgauss_pdf< Float_Type >(e.stdv, e.log_stdv, sd_mean, sd_lambda, log_sd_lambda));
+ }
+
+ friend std::ostream& operator << (std::ostream& os, const Pore_Model_State& state)
+ {
+ os << std::string(state.kmer.begin(), state.kmer.end()) << '\t'
+ << state.level_mean << '\t'
+ << state.level_stdv << '\t'
+ << state.sd_mean << '\t'
+ << state.sd_stdv;
+ return os;
+ }
+
+ friend bool operator < (const Pore_Model_State& lhs, const Pore_Model_State& rhs)
+ {
+ return lhs.kmer < rhs.kmer;
+ }
+}; // struct Pore_Model_State
+
+template < typename Float_Type, unsigned Kmer_Size = 6 >
+class Pore_Model
+{
+public:
+ typedef Kmer< Kmer_Size > Kmer_Type;
+ typedef Event< Float_Type, Kmer_Size > Event_Type;
+ typedef Pore_Model_State< Float_Type, Kmer_Size > Pore_Model_State_Type;
+ typedef Pore_Model_Parameters< Float_Type > Pore_Model_Parameters_Type;
+ static const unsigned n_states = 1u << (2 * Kmer_Size);
+
+ Pore_Model() : _strand(2) {}
+ void clear() { _state.clear(); }
+
+ const Pore_Model_State_Type& state(unsigned i) const { return _state.at(i); }
+ Pore_Model_State_Type& state(unsigned i) { return _state.at(i); }
+
+ const std::vector< Pore_Model_State_Type >& get_state_vector() const { return _state; }
+
+ const unsigned& strand() const { return _strand; }
+ unsigned& strand() { return _strand; }
+ Float_Type mean() const { return _mean; }
+ Float_Type stdv() const { return _stdv; }
+
+ void scale(const Pore_Model_Parameters_Type& params)
+ {
+ Pore_Model_Parameters_Type log_params;
+ log_params.var = std::log(params.var);
+ log_params.scale_sd = std::log(params.scale_sd);
+ log_params.var_sd = std::log(params.var_sd);
+ for(unsigned i = 0; i < n_states; ++i)
+ {
+ state(i).scale(params, log_params);
+ }
+ update_statistics();
+ }
+
+ // load model from fast5 file
+ void load_from_fast5(const fast5::File& f, bool strand)
+ {
+ assert(f.have_basecall_model(strand));
+ auto m = f.get_basecall_model(strand);
+ assert(m.size() == n_states);
+ _state.clear();
+ _state.reserve(n_states);
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ _state.emplace_back();
+ state(i) = m.at(i);
+ }
+ update_statistics();
+ }
+
+ // load from vector
+ template < typename V_Float_Type >
+ void load_from_vector(const std::vector< V_Float_Type >& v)
+ {
+ assert(v.size() == n_states * 4);
+ _state.clear();
+ _state.reserve(n_states);
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ _state.emplace_back();
+ state(i).level_mean = v[4 * i + 0];
+ state(i).level_stdv = v[4 * i + 1];
+ state(i).sd_mean = v[4 * i + 2];
+ state(i).sd_stdv = v[4 * i + 3];
+ auto s = Kmer_Type::to_string(i);
+ std::copy_n(s.begin(), Kmer_Size, state(i).kmer.begin());
+ state(i).update_sd_lambda();
+ state(i).update_logs();
+ }
+ update_statistics();
+ }
+
+ // write model to out stream
+ friend std::ostream& operator << (std::ostream& os, const Pore_Model& pm)
+ {
+ for (unsigned i = 0; i < pm.n_states; ++i)
+ {
+ os << pm.state(i) << std::endl;
+ }
+ return os;
+ }
+ // load model from input stream
+ friend std::istream& operator >> (std::istream& is, Pore_Model& pm)
+ {
+ pm._state.clear();
+ pm._state.reserve(n_states);
+ unsigned i = 0;
+ std::string line;
+ while (std::getline(is, line))
+ {
+ std::istringstream iss(line);
+ std::string s;
+ iss >> s;
+ if (s[0] == '#') continue;
+ if (line.find("kmer") != std::string::npos) continue;
+ pm._state.emplace_back();
+ iss >> pm.state(i).level_mean
+ >> pm.state(i).level_stdv
+ >> pm.state(i).sd_mean
+ >> pm.state(i).sd_stdv;
+ std::copy_n(s.begin(), Kmer_Size, pm.state(i).kmer.begin());
+ pm.state(i).update_sd_lambda();
+ pm.state(i).update_logs();
+ ++i;
+ }
+ if (i != pm.n_states)
+ {
+ LOG(error)
+ << "unexpected number of states" << std::endl;
+ std::exit(EXIT_FAILURE);
+ }
+ std::sort(pm._state.begin(), pm._state.end());
+ for (unsigned i = 0; i < pm.n_states; ++i)
+ {
+ assert(Kmer_Type::to_int(pm.state(i).kmer) == i);
+ }
+ pm.update_statistics();
+ return is;
+ }
+
+ // log of probability of an emission from a state
+ Float_Type log_pr_emission(unsigned i, const Event_Type& e) const
+ {
+ Float_Type res = state(i).log_pr_emission(e);
+ return res;
+ }
+ Float_Type log_pr_corrected_emission(unsigned i, const Event_Type& e) const
+ {
+ Float_Type res = state(i).log_pr_corrected_emission(e);
+ return res;
+ }
+
+private:
+ std::vector< Pore_Model_State_Type > _state;
+ Float_Type _mean;
+ Float_Type _stdv;
+ unsigned _strand;
+
+ void update_statistics()
+ {
+ assert(_state.size() == n_states);
+ std::tie(_mean, _stdv) = alg::mean_stdv_of< Float_Type >(
+ _state,
+ [] (const Pore_Model_State_Type& s) { return s.level_mean; });
+ }
+}; // class Pore_Model
+
+template < typename Float_Type, unsigned Kmer_Size >
+using Pore_Model_Dict = std::map< std::string, Pore_Model< Float_Type, Kmer_Size > >;
+
+#endif
diff --git a/src/nanocall/State_Transitions.hpp b/src/nanocall/State_Transitions.hpp
new file mode 100644
index 0000000..a161c84
--- /dev/null
+++ b/src/nanocall/State_Transitions.hpp
@@ -0,0 +1,258 @@
+#ifndef __STATE_TRANSITIONS_BASE_HPP
+#define __STATE_TRANSITIONS_BASE_HPP
+
+#include <cassert>
+#include <cmath>
+#include <iostream>
+#include <vector>
+#include <map>
+
+#include "Kmer.hpp"
+#include "logsumset.hpp"
+#include "logger.hpp"
+
+template < typename Float_Type >
+struct State_Transition_Parameters
+{
+ Float_Type p_stay;
+ Float_Type p_skip;
+
+ static Float_Type& default_p_stay()
+ {
+ static Float_Type _default_p_stay = .09;
+ return _default_p_stay;
+ }
+ static Float_Type& default_p_skip()
+ {
+ static Float_Type _default_p_skip = .28;
+ return _default_p_skip;
+ }
+
+ State_Transition_Parameters()
+ : p_stay(default_p_stay()), p_skip(default_p_skip()) {}
+
+ bool is_default() const
+ {
+ return p_stay == default_p_stay() and p_skip == default_p_skip();
+ }
+
+ friend std::ostream& operator << (std::ostream& os, const State_Transition_Parameters& stp)
+ {
+ os << "[p_stay=" << stp.p_stay
+ << " p_skip=" << stp.p_skip << "]";
+ return os;
+ }
+ void write_tsv(std::ostream& os) const
+ {
+ os << std::fixed << std::setprecision(5)
+ << p_stay << '\t'
+ << p_skip;
+ }
+}; // struct State_Transition_Parameters
+
+template < typename Float_Type >
+struct State_Neighbours
+{
+ State_Neighbours() : p_rest_from(-INFINITY), p_rest_to(-INFINITY) {}
+ std::vector< std::pair< unsigned, Float_Type > > from_v;
+ std::vector< std::pair< unsigned, Float_Type > > to_v;
+ Float_Type p_rest_from;
+ Float_Type p_rest_to;
+}; // struct State_Neighbours
+
+template < typename Float_Type, unsigned Kmer_Size = 6 >
+class State_Transitions
+{
+public:
+ typedef Kmer< Kmer_Size > Kmer_Type;
+ typedef State_Neighbours< Float_Type > State_Neighbours_Type;
+ typedef State_Transition_Parameters< Float_Type > State_Transition_Parameters_Type;
+ static const unsigned n_states = 1u << (2 * Kmer_Size);
+
+ State_Transitions() = default;
+ void clear() { _neighbours.clear(); }
+
+ const State_Neighbours_Type& neighbours(unsigned i) const { return _neighbours.at(i); }
+ State_Neighbours_Type& neighbours(unsigned i) { return _neighbours.at(i); }
+
+ // update fields from_v, p_rest_from, p_rest_to based on to_v
+ void update_fields()
+ {
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ neighbours(i).from_v.clear();
+ }
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ logsum::logsumset< Float_Type > s(false);
+ for (const auto& p : neighbours(i).to_v)
+ {
+ neighbours(p.first).from_v.push_back(std::make_pair(i, p.second));
+ s.add(p.second);
+ }
+ neighbours(i).p_rest_to = std::log(1 - std::exp(s.val()));
+ }
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ logsum::logsumset< Float_Type > s(false);
+ for (const auto& p : neighbours(i).from_v)
+ {
+ s.add(p.second);
+ }
+ neighbours(i).p_rest_from = std::log(1 - std::exp(s.val()));
+ }
+ }
+
+ // drop transitions with low probability
+ void drop_transitions(Float_Type p_cutoff)
+ {
+ Float_Type log_p_cutoff = std::log(p_cutoff);
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ decltype(neighbours(i).to_v) to_v;
+ for (const auto& p : neighbours(i).to_v)
+ {
+ if (p.second > log_p_cutoff)
+ {
+ to_v.push_back(p);
+ }
+ }
+ neighbours(i).to_v = std::move(to_v);
+ }
+ update_fields();
+ }
+
+ static Float_Type get_trans_prob(unsigned i, unsigned j,
+ Float_Type p_stay, Float_Type p_step, Float_Type p_skip_1)
+ {
+ Float_Type p = 0;
+ if (i == j)
+ {
+ p += p_stay;
+ }
+ if (Kmer_Type::suffix(i, Kmer_Size - 1) == Kmer_Type::prefix(j, Kmer_Size - 1))
+ {
+ p += p_step / 4;
+ }
+ for (unsigned l = 2; l < Kmer_Size; ++l)
+ if (Kmer_Type::suffix(i, Kmer_Size - l) == Kmer_Type::prefix(j, Kmer_Size - l))
+ {
+ p += pow(p_skip_1, l - 1) / (1u << (2 * l));
+ }
+ p += (pow(p_skip_1, 5) / (Float_Type(1.0) - p_skip_1)) / n_states;
+ return p;
+ }
+
+ // recompute transition table
+ void compute_transitions(Float_Type p_skip_default, Float_Type p_stay, Float_Type p_cutoff,
+ const std::map< unsigned, Float_Type >& p_skip_map = {})
+ {
+ _neighbours.clear();
+ _neighbours.reserve(n_states);
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ _neighbours.emplace_back();
+ Float_Type p_skip = p_skip_default;
+ if (p_skip_map.count(i))
+ {
+ p_skip = p_skip_map.at(i);
+ }
+ Float_Type p_step = 1.0 - p_stay - p_skip;
+ // p_skip = sum_{i>=1} p_skip_1^i
+ Float_Type p_skip_1 = p_skip / (p_skip + 1.0);
+ LOG(debug2) << "i=" << Kmer_Type::to_string(i)
+ << " p_stay=" << p_stay
+ << " p_skip=" << p_skip
+ << " p_step=" << p_step
+ << " p_skip_1=" << p_skip_1 << std::endl;
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ Float_Type p = get_trans_prob(i, j, p_stay, p_step, p_skip_1);
+ if (p > p_cutoff)
+ {
+ neighbours(i).to_v.push_back(std::make_pair(j, std::log(p)));
+ }
+ }
+ }
+ update_fields();
+ }
+
+ // compute transition table allowing a maximum of 1 skip
+ void compute_transitions_fast(Float_Type p_skip_default, Float_Type p_stay,
+ const std::map< unsigned, Float_Type >& p_skip_map = {})
+ {
+ struct Default_Float_Type
+ {
+ Default_Float_Type(Float_Type _val = 0.0) : val(_val) {}
+ Float_Type val;
+ }; // struct Default_Float
+
+ _neighbours.clear();
+ _neighbours.reserve(n_states);
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ _neighbours.emplace_back();
+ Float_Type p_skip = p_skip_default;
+ if (p_skip_map.count(i))
+ {
+ p_skip = p_skip_map.at(i);
+ }
+ Float_Type p_step = 1.0 - p_stay - p_skip;
+ // p_skip = sum_{i>=1} p_skip_1^i
+ Float_Type p_skip_1 = p_skip / (p_skip + 1.0);
+ LOG(debug2) << "i=" << Kmer_Type::to_string(i)
+ << " p_stay=" << p_stay
+ << " p_skip=" << p_skip
+ << " p_step=" << p_step
+ << " p_skip_1=" << p_skip_1 << std::endl;
+ std::set< unsigned > to_s{i};
+ const auto& nl1 = Kmer_Type::neighbour_list(i, 1);
+ to_s.insert(nl1.begin(), nl1.end());
+ const auto& nl2 = Kmer_Type::neighbour_list(i, 2);
+ to_s.insert(nl2.begin(), nl2.end());
+ for (const auto& j : to_s)
+ {
+ Float_Type p = get_trans_prob(i, j, p_stay, p_step, p_skip_1);
+ neighbours(i).to_v.push_back(std::make_pair(j, std::log(p)));
+ }
+ }
+ update_fields();
+ }
+ void compute_transitions_fast(const State_Transition_Parameters_Type& stp)
+ {
+ compute_transitions_fast(stp.p_skip, stp.p_stay);
+ }
+
+ friend std::ostream& operator << (std::ostream& os, const State_Transitions& st)
+ {
+ for (unsigned i = 0; i < n_states; ++i)
+ {
+ for (const auto& p : st.neighbours(i).to_v)
+ {
+ os << Kmer_Type::to_string(i) << '\t' << Kmer_Type::to_string(p.first) << '\t' << p.second << std::endl;
+ }
+ }
+ return os;
+ }
+ friend std::istream& operator >> (std::istream& is, State_Transitions& st)
+ {
+ st._neighbours.clear();
+ st._neighbours.resize(n_states);
+ std::string k_i;
+ std::string k_j;
+ Float_Type p;
+ while (is >> k_i >> k_j >> p)
+ {
+ unsigned i = Kmer_Type::to_int(k_i);
+ unsigned j = Kmer_Type::to_int(k_j);
+ st.neighbours(i).to_v.push_back(std::make_pair(j, p));
+ }
+ st.update_fields();
+ return is;
+ }
+
+private:
+ std::vector< State_Neighbours_Type > _neighbours;
+}; // class State_Transitions
+
+#endif
diff --git a/src/nanocall/Viterbi.hpp b/src/nanocall/Viterbi.hpp
new file mode 100644
index 0000000..223d0ba
--- /dev/null
+++ b/src/nanocall/Viterbi.hpp
@@ -0,0 +1,154 @@
+#ifndef __VITERBI_HPP
+#define __VITERBI_HPP
+
+#include <cmath>
+#include <iostream>
+#include <vector>
+#include <set>
+
+#include "Pore_Model.hpp"
+#include "State_Transitions.hpp"
+#include "logsumset.hpp"
+#include "logger.hpp"
+#include "fast5.hpp"
+
+template < typename Float_Type, unsigned Kmer_Size = 6 >
+class Viterbi
+{
+public:
+ typedef Kmer< Kmer_Size > Kmer_Type;
+ typedef Pore_Model< Float_Type, Kmer_Size > Pore_Model_Type;
+ typedef State_Transitions< Float_Type, Kmer_Size > State_Transitions_Type;
+ typedef Event< Float_Type, Kmer_Size > Event_Type;
+ typedef Event_Sequence< Float_Type, Kmer_Size > Event_Sequence_Type;
+ typedef logsum::logsumset< Float_Type > LogSumSet_Type;
+
+ struct Matrix_Entry
+ {
+ Float_Type alpha; // := Pr[ MLSS producing e_1 ... e_i, with S_i == j ]
+ unsigned beta; // := previous state in the MLSS
+ }; // struct Matrix_Entry
+
+ static const unsigned n_states = Pore_Model_Type::n_states;
+
+ unsigned n_events() const { return _n_events; }
+ Float_Type path_probability() const { return _path_probability; }
+
+ // i: event index
+ // j: state/kmer index
+ const Matrix_Entry& cell(unsigned i, unsigned j) const { return _m[i * n_states + j]; }
+ Matrix_Entry& cell(unsigned i, unsigned j) { return _m[i * n_states + j]; }
+
+ static unsigned& n_threads() { static unsigned _n_threads = 1; return _n_threads; }
+
+ void fill(const Pore_Model_Type& pm,
+ const State_Transitions_Type& st,
+ Event_Sequence_Type& ev)
+ {
+ _n_events = ev.size();
+ _m.clear();
+ _m.resize(n_states * n_events());
+ Float_Type log_n_states = std::log(static_cast< Float_Type >(n_states));
+ //
+ // alpha, beta; i == 0
+ //
+ {
+ LOG("Viterbi", debug1) << "forward: i=0" << std::endl;
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ // alpha
+ cell(0, j).alpha = pm.log_pr_corrected_emission(j, ev[0]) - log_n_states;
+ // beta
+ cell(0, j).beta = n_states;
+ LOG("Viterbi", debug2)
+ << "i=0 j=" << Kmer_Type::to_string(j)
+ << " alpha=" << cell(0, j).alpha
+ << " beta=" << cell(0, j).beta << std::endl;
+ }
+ }
+ //
+ // alpha, beta; i > 0
+ //
+ for (unsigned i = 1; i < n_events(); ++i)
+ {
+ LOG("Viterbi", debug1) << "forward: i=" << i << std::endl;
+ for (unsigned j = 0; j < n_states; ++j) // TODO: parallelize
+ {
+ cell(i, j).alpha = -INFINITY;
+ cell(i, j).beta = n_states;
+ for (const auto& p : st.neighbours(j).from_v)
+ {
+ const unsigned& j_prev = p.first;
+ const Float_Type& log_pr_transition = p.second;
+ Float_Type v = log_pr_transition + cell(i - 1, j_prev).alpha;
+ if (v > cell(i, j).alpha)
+ {
+ cell(i, j).alpha = v;
+ cell(i, j).beta = j_prev;
+ }
+ }
+ cell(i, j).alpha += pm.log_pr_corrected_emission(j, ev[i]);
+ LOG("Viterbi", debug2)
+ << "i=" << i << " j=" << Kmer_Type::to_string(j)
+ << " alpha=" << cell(i, j).alpha
+ << " beta=" << cell(i, j).beta << std::endl;
+ }
+ }
+ fill_state_seq(ev);
+ fill_move_seq(ev);
+ }
+
+ friend std::ostream& operator << (std::ostream& os, const Viterbi& vit)
+ {
+ for (unsigned i = 0; i < vit.n_events(); ++i)
+ {
+ for (unsigned j = 0; j < vit.n_states; ++j)
+ {
+ os << i << '\t' << j << '\t'
+ << vit.cell(i, j).alpha << '\t'
+ << vit.cell(i, j).beta << std::endl;
+ }
+ }
+ return os;
+ }
+
+private:
+ std::vector< Matrix_Entry > _m;
+ Float_Type _path_probability;
+ unsigned _n_events;
+
+ void fill_state_seq(Event_Sequence_Type& ev)
+ {
+ assert(Kmer_Size <= MAX_K_LEN);
+ Float_Type max_v = -INFINITY;
+ unsigned max_j = n_states;
+ for (unsigned j = 0; j < n_states; ++j)
+ {
+ if (cell(n_events() - 1, j).alpha > max_v)
+ {
+ max_j = j;
+ max_v = cell(n_events() - 1, j).alpha;
+ }
+ }
+ _path_probability = max_v;
+ for (unsigned i = n_events() - 1; i > 0; --i)
+ {
+ ev[i].model_state_idx = max_j;
+ ev[i].set_model_state(Kmer_Type::to_string(ev[i].model_state_idx));
+ max_j = cell(i, max_j).beta;
+ }
+ ev[0].model_state_idx = max_j;
+ ev[0].set_model_state(Kmer_Type::to_string(ev[0].model_state_idx));
+ }
+
+ void fill_move_seq(Event_Sequence_Type& ev)
+ {
+ for (unsigned i = 0; i < n_events(); ++i)
+ {
+ ev[i].move = i > 0? Kmer_Type::min_skip(ev[i - 1].model_state_idx, ev[i].model_state_idx) : 0u;
+ }
+ }
+
+}; // class Viterbi
+
+#endif
diff --git a/src/nanocall/compute-scaled-pore-model.cpp b/src/nanocall/compute-scaled-pore-model.cpp
new file mode 100644
index 0000000..38a54b5
--- /dev/null
+++ b/src/nanocall/compute-scaled-pore-model.cpp
@@ -0,0 +1,51 @@
+#include <iostream>
+#include <string>
+#include <tclap/CmdLine.h>
+
+#include "zstr.hpp"
+#include "Pore_Model.hpp"
+#include "logger.hpp"
+
+using namespace std;
+
+#ifndef FLOAT_TYPE
+#define FLOAT_TYPE float
+#endif
+typedef Pore_Model< FLOAT_TYPE > Pore_Model_Type;
+typedef Pore_Model_Type::Pore_Model_Parameters_Type Pore_Model_Parameters_Type;
+
+namespace opts
+{
+ using namespace TCLAP;
+ string description =
+ "Compute scaled pore model.";
+ CmdLine cmd_parser(description);
+ MultiArg< string > log_level("d", "log-level", "Log level.", false, "string", cmd_parser);
+ ValueArg< string > file_name("f", "file-name", "Fast5 file.", true, "", "file", cmd_parser);
+ ValueArg< unsigned > strand("s", "strand", "Strand.", false, 0, "file", cmd_parser);
+ ValueArg< string > output_file_name("o", "output", "Output file name.", false, "", "file", cmd_parser);
+} // namespace opts
+
+void real_main()
+{
+ Pore_Model_Type m;
+ Pore_Model_Parameters_Type m_params;
+ m.load_from_fast5(fast5::File(opts::file_name), opts::strand);
+ m_params.load_from_fast5(fast5::File(opts::file_name), opts::strand);
+ m.scale(m_params);
+ if (not opts::output_file_name.get().empty())
+ {
+ strict_fstream::ofstream(opts::output_file_name.get()) << m;
+ }
+ else
+ {
+ cout << m;
+ }
+}
+
+int main(int argc, char * argv[])
+{
+ opts::cmd_parser.parse(argc, argv);
+ logger::Logger::set_levels_from_options(opts::log_level);
+ real_main();
+}
diff --git a/src/nanocall/compute-state-transitions.cpp b/src/nanocall/compute-state-transitions.cpp
new file mode 100644
index 0000000..8de12dd
--- /dev/null
+++ b/src/nanocall/compute-state-transitions.cpp
@@ -0,0 +1,56 @@
+#include <iostream>
+#include <string>
+#include <tclap/CmdLine.h>
+
+#include "zstr.hpp"
+#include "State_Transitions.hpp"
+#include "logger.hpp"
+
+using namespace std;
+
+#ifndef FLOAT_TYPE
+#define FLOAT_TYPE float
+#endif
+typedef State_Transitions< FLOAT_TYPE > State_Transitions_Type;
+
+namespace opts
+{
+ using namespace TCLAP;
+ string description =
+ "Compute state transition probabilities based on the overlap model, for a given pr_skip and pr_stay.";
+ CmdLine cmd_parser(description);
+ MultiArg< string > log_level("d", "log-level", "Log level.", false, "string", cmd_parser);
+ ValueArg< string > output_file_name("o", "output", "Output file name.", false, "", "file", cmd_parser);
+ ValueArg< float > p_cutoff("p", "pr-cutoff", "Minimim prob to keep.", false, 0.001, "float", cmd_parser);
+ ValueArg< float > p_skip("k", "pr-skip", "Pr skip.", false, 0.28, "float", cmd_parser);
+ ValueArg< float > p_stay("t", "pr-stay", "Pr stay.", false, 0.09, "float", cmd_parser);
+ SwitchArg fast("", "fast", "Use fast computation.", cmd_parser);
+} // namespace opts
+
+void real_main()
+{
+ State_Transitions_Type st;
+ if (opts::fast)
+ {
+ st.compute_transitions_fast(opts::p_skip, opts::p_stay);
+ }
+ else
+ {
+ st.compute_transitions(opts::p_skip, opts::p_stay, opts::p_cutoff);
+ }
+ if (not opts::output_file_name.get().empty())
+ {
+ strict_fstream::ofstream(opts::output_file_name) << st;
+ }
+ else
+ {
+ cout << st;
+ }
+}
+
+int main(int argc, char * argv[])
+{
+ opts::cmd_parser.parse(argc, argv);
+ logger::Logger::set_levels_from_options(opts::log_level);
+ real_main();
+}
diff --git a/src/nanocall/fs_support.hpp b/src/nanocall/fs_support.hpp
new file mode 100644
index 0000000..a458ee8
--- /dev/null
+++ b/src/nanocall/fs_support.hpp
@@ -0,0 +1,38 @@
+#ifndef __FS_SUPPORT_HPP
+#define __FS_SUPPORT_HPP
+
+#include <string>
+#include <vector>
+
+#include <sys/types.h>
+#include <dirent.h>
+
+// This should work in windows.
+// Ref:
+// http://stackoverflow.com/a/612176/717706
+
+bool is_directory(const std::string& file_name)
+{
+ auto dir = opendir(file_name.c_str());
+ if (not dir) return false;
+ closedir(dir);
+ return true;
+}
+
+std::vector< std::string > list_directory(const std::string& file_name)
+{
+ std::vector< std::string > res;
+ DIR* dir;
+ struct dirent *ent;
+
+ dir = opendir(file_name.c_str());
+ if (not dir) return res;
+ while ((ent = readdir(dir)) != nullptr)
+ {
+ res.push_back(ent->d_name);
+ }
+ closedir(dir);
+ return res;
+}
+
+#endif
diff --git a/src/nanocall/global_assert.hpp b/src/nanocall/global_assert.hpp
new file mode 100644
index 0000000..d011694
--- /dev/null
+++ b/src/nanocall/global_assert.hpp
@@ -0,0 +1,61 @@
+//-----------------------------------------------
+// Copyright 2013 Ontario Institute for Cancer Research
+// Written by Matei David (mdavid at oicr.on.ca)
+// Released under the GPL license
+//-----------------------------------------------
+
+#ifndef __GLOBAL_ASSERT_HPP
+#define __GLOBAL_ASSERT_HPP
+
+#include <iostream>
+#include <string>
+
+struct global_assert
+{
+ static std::string& prog_name()
+ {
+ static std::string _prog_name;
+ return _prog_name;
+ }
+ static std::string& global_msg()
+ {
+ static thread_local std::string _global_msg;
+ return _global_msg;
+ }
+
+ static void assertion_failed(const std::string& expr, const std::string& msg,
+ const std::string& function, const std::string& file, long line)
+ {
+ std::cerr << prog_name() << ": "
+ << file << ":" << line << ": "
+ << function;
+ if (not global_msg().empty())
+ {
+ std::cerr << " [" << global_msg() << "]";
+ }
+ std::cerr << ": " << "Assertion '" << expr << "' failed";
+ if (not msg.empty())
+ {
+ std::cerr << ": " << msg;
+ }
+ std::cerr << std::endl;
+ abort();
+ }
+}; // struct global_assert
+
+#undef ASSERT
+#undef ASSERT_MSG
+
+#if defined(NDEBUG)
+
+#define ASSERT(expr) ((void)0)
+#define ASSERT_MSG(expr, msg) ((void)0)
+
+#else
+
+#define ASSERT_MSG(expr, msg) ((expr)? ((void)0): global_assert::assertion_failed(#expr, msg, __func__, __FILE__, __LINE__))
+#define ASSERT(expr) ASSERT_MSG(expr, "")
+
+#endif
+
+#endif
diff --git a/src/nanocall/list-directory.cpp b/src/nanocall/list-directory.cpp
new file mode 100644
index 0000000..b2ea7f8
--- /dev/null
+++ b/src/nanocall/list-directory.cpp
@@ -0,0 +1,27 @@
+#include <iostream>
+#include <string>
+
+#include "fs_support.hpp"
+
+using namespace std;
+
+int main(int argc, char* argv[])
+{
+ if (argc != 2)
+ {
+ cerr << "use: " << argv[0] << " <directory>" << endl;
+ return EXIT_FAILURE;
+ }
+ string file_name = argv[1];
+ auto is_dir = is_directory(file_name);
+ if (not is_dir)
+ {
+ cerr << "not a directory: " << file_name << endl;
+ return EXIT_FAILURE;
+ }
+ auto l = list_directory(file_name);
+ for (const auto& f : l)
+ {
+ cout << f << endl;
+ }
+}
diff --git a/src/nanocall/nanocall.cpp b/src/nanocall/nanocall.cpp
new file mode 100644
index 0000000..e17e475
--- /dev/null
+++ b/src/nanocall/nanocall.cpp
@@ -0,0 +1,1041 @@
+#include <deque>
+#include <iostream>
+#include <string>
+#include <tclap/CmdLine.h>
+
+#include <ctime>
+
+#include "global_assert.hpp"
+#include "version.hpp"
+#include "Pore_Model.hpp"
+#include "Builtin_Model.hpp"
+#include "State_Transitions.hpp"
+#include "Event.hpp"
+#include "Fast5_Summary.hpp"
+#include "Viterbi.hpp"
+#include "Forward_Backward.hpp"
+#include "Parameter_Trainer.hpp"
+#include "logger.hpp"
+#include "alg.hpp"
+#include "zstr.hpp"
+#include "fast5.hpp"
+#include "pfor.hpp"
+#include "fs_support.hpp"
+
+using namespace std;
+
+long get_cpu_time_ms()
+{
+ auto t = clock();
+ return (t * 1000) / CLOCKS_PER_SEC;
+}
+
+#ifndef FLOAT_TYPE
+#define FLOAT_TYPE float
+#endif
+#ifndef KMER_SIZE
+#define KMER_SIZE 6
+#endif
+typedef State_Transitions< FLOAT_TYPE, KMER_SIZE > State_Transitions_Type;
+typedef State_Transition_Parameters< FLOAT_TYPE > State_Transition_Parameters_Type;
+typedef Pore_Model< FLOAT_TYPE, KMER_SIZE > Pore_Model_Type;
+typedef Pore_Model_Dict< FLOAT_TYPE, KMER_SIZE > Pore_Model_Dict_Type;
+typedef Pore_Model_Parameters< FLOAT_TYPE > Pore_Model_Parameters_Type;
+typedef Event< FLOAT_TYPE, KMER_SIZE > Event_Type;
+typedef Event_Sequence< FLOAT_TYPE, KMER_SIZE > Event_Sequence_Type;
+typedef Fast5_Summary< FLOAT_TYPE, KMER_SIZE > Fast5_Summary_Type;
+typedef Parameter_Trainer< FLOAT_TYPE, KMER_SIZE > Parameter_Trainer_Type;
+typedef Viterbi< FLOAT_TYPE, KMER_SIZE > Viterbi_Type;
+
+namespace opts
+{
+ using namespace TCLAP;
+ string description = "Call bases in Oxford Nanopore reads.";
+ CmdLine cmd_parser(description, ' ', package_version);
+ //
+ ValueArg< string > ed_group("", "ed-group", "EventDetection group to use. (default: smallest available)", false, "", "000|001|...", cmd_parser);
+ ValueArg< unsigned > chunk_size("", "chunk-size", "Thread chunk size.", false, 1, "int", cmd_parser);
+ MultiArg< string > log_level("", "log", "Log level. (default: info)", false, "string", cmd_parser);
+ ValueArg< string > stats_fn("", "stats", "Stats.", false, "", "file", cmd_parser);
+ ValueArg< unsigned > max_ed_events("", "max-ed-events", "Maximum EventDetection events.", false, 100000, "int", cmd_parser);
+ ValueArg< unsigned > min_ed_events("", "min-ed-events", "Minimum EventDetection events.", false, 10, "int", cmd_parser);
+ ValueArg< unsigned > fasta_line_width("", "fasta-line-width", "Maximum fasta line width.", false, 80, "int", cmd_parser);
+ //
+ ValueArg< float > scaling_select_threshold("", "scaling-select-threshold", "Select best model per strand during scaling if log score better by threshold.", false, 20.0, "float", cmd_parser);
+ ValueArg< float > scaling_min_progress("", "scaling-min-progress", "Minimum scaling fit progress.", false, 1.0, "float", cmd_parser);
+ ValueArg< unsigned > scaling_max_rounds("", "scaling-max-rounds", "Maximum scaling rounds.", false, 10, "int", cmd_parser);
+ ValueArg< unsigned > scaling_num_events("", "scaling-num-events", "Number of events used for model scaling.", false, 200, "int", cmd_parser);
+ //
+ SwitchArg single_strand_scaling("", "single-strand-scaling", "Train scaling parameters per strand.", cmd_parser);
+ SwitchArg double_strand_scaling("", "double-strand-scaling", "Train scaling parameters per read. (default)", cmd_parser);
+ SwitchArg no_train_transitions("", "no-train-transitions", "Do not train state transitions.", cmd_parser);
+ SwitchArg no_train_scaling("", "no-train-scaling", "Do not train pore model scaling.", cmd_parser);
+ SwitchArg train("", "train", "Enable training. (default)", cmd_parser);
+ SwitchArg no_train("", "no-train", "Disable all training.", cmd_parser);
+ SwitchArg basecall("", "basecall", "Enable basecalling (default).", cmd_parser);
+ SwitchArg no_basecall("", "no-basecall", "Disable basecalling.", cmd_parser);
+ //
+ ValueArg< float > pr_skip("", "pr-skip", "Transition probability of skipping at least 1 state.", false, .3, "float", cmd_parser);
+ ValueArg< float > pr_stay("", "pr-stay", "Transition probability of staying in the same state.", false, .1, "float", cmd_parser);
+ ValueArg< string > trans_fn("s", "trans", "Custom initial state transitions.", false, "", "file", cmd_parser);
+ ValueArg< string > model_fofn("", "model-fofn", "File of pore models.", false, "", "file", cmd_parser);
+ MultiArg< string > model_fn("m", "model", "Custom pore model for strand (0=template, 1=complement, 2=both).", false, "strand:file", cmd_parser);
+ //
+ ValueArg< string > pore("", "pore", "Pore name, used to select builtin pore model.", false, "r9", "r73|r9", cmd_parser);
+ SwitchArg write_fast5("", "write-fast5", "Write basecalls to fast5 files.", cmd_parser);
+ ValueArg< string > output_fn("o", "output", "Output.", false, "", "file", cmd_parser);
+ ValueArg< unsigned > num_threads("t", "threads", "Number of parallel threads.", false, 1, "int", cmd_parser);
+ UnlabeledMultiArg< string > input_fn("inputs", "Inputs: directories, fast5 files, or files of fast5 file names (use \"-\" to read fofn from stdin).", true, "path", cmd_parser);
+} // namespace opts
+
+void init_models(Pore_Model_Dict_Type& models)
+{
+ auto parse_model_name = [] (const string& s) {
+ if (s.size() < 3
+ or (s[0] != '0' and s[0] != '1' and s[0] != '2')
+ or s[1] != ':')
+ {
+ LOG(error) << "could not parse model name: \"" << s << "\"; format should be \"[0|1|2]:<file>\"" << endl;
+ exit(EXIT_FAILURE);
+ }
+ unsigned st = s[0] - '0';
+ return make_pair(st, s.substr(2));
+ };
+
+ map< unsigned, list< string > > model_list;
+ if (not opts::model_fn.get().empty())
+ {
+ for (const auto& s : opts::model_fn.get())
+ {
+ auto p = parse_model_name(s);
+ model_list[p.first].push_back(p.second);
+ }
+ }
+ if (not opts::model_fofn.get().empty())
+ {
+ zstr::ifstream ifs(opts::model_fofn);
+ string s;
+ while (getline(ifs, s))
+ {
+ auto p = parse_model_name(s);
+ model_list[p.first].push_back(p.second);
+ }
+ }
+ if (model_list[2].empty() and (model_list[0].empty() != model_list[1].empty()))
+ {
+ LOG(error) << "models were specified only for strand " << (int)model_list[0].empty()
+ << "! give models for both strands, or for neither." << endl;
+ exit(EXIT_FAILURE);
+ }
+ if (not (model_list[0].empty() and model_list[1].empty() and model_list[2].empty()))
+ {
+ for (unsigned st = 0; st < 3; ++st)
+ {
+ for (const auto& e : model_list[st])
+ {
+ Pore_Model_Type pm;
+ string pm_name = e;
+ zstr::ifstream(e) >> pm;
+ pm.strand() = st;
+ models[pm_name] = move(pm);
+ LOG(info) << "loaded module [" << pm_name
+ << "] for strand [" << st
+ << "] statistics [mean=" << pm.mean()
+ << ", stdv=" << pm.stdv() << "]" << endl;
+ }
+ }
+ }
+ else
+ {
+ // use built-in models
+ for (unsigned i = 0; i < Builtin_Model::num; ++i)
+ {
+ Pore_Model_Type pm;
+ string pm_name = Builtin_Model::names[i];
+ if (pm_name.compare(0, opts::pore.get().size() + 1, opts::pore.get() + ".")) continue;
+ pm.load_from_vector(Builtin_Model::init_lists[i]);
+ pm.strand() = Builtin_Model::strands[i];
+ models[Builtin_Model::names[i]] = move(pm);
+ LOG(info)
+ << "loaded builtin module [" << Builtin_Model::names[i]
+ << "] for strand [" << Builtin_Model::strands[i]
+ << "] statistics [mean=" << pm.mean()
+ << ", stdv=" << pm.stdv() << "]" << endl;
+ }
+ if (models.empty())
+ {
+ LOG(error)
+ << "no builtin models found for pore [" << opts::pore.get() << "]" << endl;
+ exit(EXIT_FAILURE);
+ }
+ }
+} // init_models
+
+void init_transitions(State_Transitions_Type& transitions)
+{
+ if (not opts::trans_fn.get().empty())
+ {
+ zstr::ifstream(opts::trans_fn) >> transitions;
+ LOG(info) << "loaded state transitions from [" << opts::trans_fn.get() << "]" << endl;
+ }
+ else
+ {
+ transitions.compute_transitions_fast(opts::pr_skip, opts::pr_stay);
+ LOG(info) << "init_state_transitions pr_skip=[" << opts::pr_skip
+ << "], pr_stay=[" << opts::pr_stay << "]" << endl;
+ }
+} // init_transitions
+
+// Parse command line arguments. For each of them:
+// - if it is a directory, find all fast5 files in it, ignore non-fast5 files.
+// - if it is a file, check that it is indeed a fast5 file.
+void init_files(list< string >& files)
+{
+ for (const auto& f : opts::input_fn)
+ {
+ if (is_directory(f))
+ {
+ auto l = list_directory(f);
+ for (const auto& g : l)
+ {
+ string f2 = f + (f[f.size() - 1] != '/'? "/" : "") + g;
+ if (is_directory(f2))
+ {
+ LOG(info) << "ignoring subdirectory [" << f2 << "]" << endl;
+ }
+ else if (fast5::File::is_valid_file(f2))
+ {
+ files.push_back(f2);
+ LOG(info) << "adding input file [" << f2 << "]" << endl;
+ }
+ else
+ {
+ LOG(info) << "ignoring file [" << f2 << "]" << endl;
+ }
+ }
+ }
+ else // not a directory
+ {
+ if (f != "-" and fast5::File::is_valid_file(f))
+ {
+ files.push_back(f);
+ LOG(info) << "adding input file [" << f << "]" << endl;
+ }
+ else // not fast5, interpret as fofn
+ {
+ LOG(info) << "interpreting [" << f << "] as fofn" << endl;
+ istream* is_p = nullptr;
+ strict_fstream::ifstream ifs;
+ if (f == "-")
+ {
+ is_p = &cin;
+ }
+ else
+ {
+ ifs.open(f);
+ is_p = &ifs;
+ }
+ string g;
+ while (getline(*is_p, g))
+ {
+ if (fast5::File::is_valid_file(g))
+ {
+ files.push_back(g);
+ LOG(info) << "adding input file [" << g << "]" << endl;
+ }
+ }
+ }
+ }
+ }
+ if (files.empty())
+ {
+ LOG(error) << "no fast5 files to process" << endl;
+ exit(EXIT_FAILURE);
+ }
+} // init_files
+
+void init_reads(const Pore_Model_Dict_Type& models,
+ const list< string >& files,
+ deque< Fast5_Summary_Type >& reads)
+{
+ for (const auto& f : files)
+ {
+ Fast5_Summary_Type s(f, models, opts::double_strand_scaling);
+ LOG(info) << "summary: " << s << endl;
+ reads.emplace_back(move(s));
+ }
+} // init_reads
+
+void train_reads(const Pore_Model_Dict_Type& models,
+ const State_Transitions_Type& default_transitions,
+ deque< Fast5_Summary_Type >& reads)
+{
+ auto time_start_ms = get_cpu_time_ms();
+ Parameter_Trainer_Type::init();
+ unsigned crt_idx = 0;
+ pfor::pfor< unsigned >(
+ opts::num_threads,
+ opts::chunk_size,
+ // get_item
+ [&] (unsigned& i) {
+ if (crt_idx >= reads.size()) return false;
+ i = crt_idx++;
+ return true;
+ },
+ // process item
+ [&] (unsigned& i) {
+ Fast5_Summary_Type& read_summary = reads[i];
+ if (read_summary.num_ed_events == 0) return;
+ global_assert::global_msg() = read_summary.read_id;
+ read_summary.load_events();
+ //
+ // create per-strand list of models to try
+ //
+ array< list< string >, 2 > model_list;
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ // if not enough events, ignore strand
+ if (read_summary.events(st).size() < opts::min_ed_events) continue;
+ // create list of models to try
+ if (not read_summary.preferred_model[st][st].empty())
+ {
+ // if we have a preferred model, use that
+ model_list[st].push_back(read_summary.preferred_model[st][st]);
+ }
+ else
+ {
+ // no preferred model, try all that apply to this strand
+ for (const auto& p : models)
+ {
+ if (p.second.strand() == st or p.second.strand() == 2)
+ {
+ model_list[st].push_back(p.first);
+ }
+ }
+ }
+ ASSERT(not model_list.empty());
+ }
+ //
+ // create per-strand list of event sequences on which to train
+ //
+ array< vector< Event_Sequence_Type >, 2 > train_event_seqs;
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ // if not enough events, ignore strand
+ if (read_summary.events(st).size() < opts::min_ed_events) continue;
+ // create 2 event sequences on which to train
+ unsigned num_train_events = min((size_t)opts::scaling_num_events.get(), read_summary.events(st).size());
+ train_event_seqs[st].emplace_back(
+ read_summary.events(st).begin(), read_summary.events(st).begin() + num_train_events / 2);
+ train_event_seqs[st].emplace_back(
+ read_summary.events(st).end() - num_train_events / 2, read_summary.events(st).end());
+ }
+ //
+ // branch on whether pore models should be scaled together
+ //
+ if (read_summary.scale_strands_together)
+ {
+ // prepare vector of event sequences
+ vector< pair< const Event_Sequence_Type*, unsigned > > train_event_seq_ptrs;
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ for (const auto& events : train_event_seqs[st])
+ {
+ train_event_seq_ptrs.push_back(make_pair(&events, st));
+ }
+ }
+ // track model fit
+ // key = pore model name; value = fit
+ map< array< string, 2 >, FLOAT_TYPE > model_fit;
+ for (const auto& m_name_0 : model_list[0])
+ {
+ for (const auto& m_name_1 : model_list[1])
+ {
+ array< string, 2 > m_name_key = {{ m_name_0, m_name_1 }};
+ string m_name = m_name_0 + "+" + m_name_1;
+ unsigned round = 0;
+ auto& crt_pm_params = read_summary.pm_params_m.at(m_name_key);
+ auto& crt_st_params = read_summary.st_params_m.at(m_name_key);
+ auto& crt_fit = model_fit[m_name_key];
+ crt_fit = -INFINITY;
+ while (true)
+ {
+ Pore_Model_Parameters_Type old_pm_params(crt_pm_params);
+ std::array< State_Transition_Parameters_Type, 2 > old_st_params(crt_st_params);
+ auto old_fit = crt_fit;
+ bool done;
+
+ Parameter_Trainer_Type::train_one_round(
+ train_event_seq_ptrs,
+ {{ &models.at(m_name_0), &models.at(m_name_1) }},
+ default_transitions,
+ old_pm_params, old_st_params,
+ crt_pm_params, crt_st_params, crt_fit, done,
+ not opts::no_train_scaling, not opts::no_train_transitions);
+
+ LOG(debug)
+ << "scaling_round read [" << read_summary.read_id
+ << "] strand [" << 2
+ << "] model [" << m_name
+ << "] old_pm_params [" << old_pm_params
+ << "] old_st_params [" << old_st_params[0] << "," << old_st_params[1]
+ << "] old_fit [" << old_fit
+ << "] crt_pm_params [" << crt_pm_params
+ << "] crt_st_params [" << crt_st_params[0] << "," << crt_st_params[1]
+ << "] crt_fit [" << crt_fit
+ << "] round [" << round << "]" << endl;
+
+ if (done)
+ {
+ // singularity detected; stop
+ break;
+ }
+
+ if (crt_fit < old_fit)
+ {
+ LOG(info) << "scaling_regression read [" << read_summary.read_id
+ << "] strand [" << 2
+ << "] model [" << m_name
+ << "] old_params [" << old_pm_params
+ << "] old_st_params [" << old_st_params[0] << "," << old_st_params[1]
+ << "] old_fit [" << old_fit
+ << "] crt_pm_params [" << crt_pm_params
+ << "] crt_st_params [" << crt_st_params[0] << "," << crt_st_params[1]
+ << "] crt_fit [" << crt_fit
+ << "] round [" << round << "]" << endl;
+ crt_pm_params = old_pm_params;
+ crt_st_params = old_st_params;
+ crt_fit = old_fit;
+ break;
+ }
+
+ ++round;
+ // stop condition
+ if (round >= 2u * opts::scaling_max_rounds
+ or (round > 1 and crt_fit < old_fit + opts::scaling_min_progress))
+ {
+ break;
+ }
+
+ }; // while true
+ LOG(info)
+ << "scaling_result read [" << read_summary.read_id
+ << "] strand [" << 2
+ << "] model [" << m_name
+ << "] pm_params [" << crt_pm_params
+ << "] st_params [" << crt_st_params[0] << "," << crt_st_params[1]
+ << "] fit [" << crt_fit
+ << "] rounds [" << round << "]" << endl;
+ } // for m_name[1]
+ } // for m_name[0]
+ if (opts::scaling_select_threshold.get() < INFINITY)
+ {
+ auto it_max = alg::max_of(
+ model_fit,
+ [] (const decltype(model_fit)::value_type& p) { return p.second; });
+ // check maximum is unique
+ if (alg::all_of(
+ model_fit,
+ [&] (const decltype(model_fit)::value_type& p) {
+ return &p == &*it_max
+ or p.second + opts::scaling_select_threshold.get() < it_max->second;
+ }))
+ {
+ const auto& m_name_0 = it_max->first[0];
+ const auto& m_name_1 = it_max->first[1];
+ auto m_name = m_name_0 + '+' + m_name_1;
+ read_summary.preferred_model[2][0] = m_name_0;
+ read_summary.preferred_model[2][1] = m_name_1;
+ LOG(info)
+ << "selected_model read [" << read_summary.read_id
+ << "] strand [2] model [" << m_name << "]" << endl;
+ }
+ }
+ }
+ else // not scale_strands_together
+ {
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ // if not enough events, ignore strand
+ if (read_summary.events(st).size() < opts::min_ed_events) continue;
+ // prepare vector of event sequences
+ vector< pair< const Event_Sequence_Type*, unsigned > > train_event_seq_ptrs;
+ for (const auto& events : train_event_seqs[st])
+ {
+ train_event_seq_ptrs.push_back(make_pair(&events, st));
+ }
+ map< string, FLOAT_TYPE > model_fit;
+ for (const auto& m_name : model_list[st])
+ {
+ array< string, 2 > m_name_key;
+ m_name_key[st] = m_name;
+ unsigned round = 0;
+ auto& crt_pm_params = read_summary.pm_params_m.at(m_name_key);
+ auto& crt_st_params = read_summary.st_params_m.at(m_name_key);
+ auto& crt_fit = model_fit[m_name];
+ crt_fit = -INFINITY;
+ while (true)
+ {
+ Pore_Model_Parameters_Type old_pm_params(crt_pm_params);
+ array< State_Transition_Parameters_Type, 2 > old_st_params(crt_st_params);
+ auto old_fit = crt_fit;
+ bool done;
+
+ Parameter_Trainer_Type::train_one_round(
+ train_event_seq_ptrs,
+ {{ &models.at(m_name), &models.at(m_name) }},
+ default_transitions,
+ old_pm_params, old_st_params,
+ crt_pm_params, crt_st_params, crt_fit, done,
+ not opts::no_train_scaling, not opts::no_train_transitions);
+
+ LOG(debug)
+ << "scaling_round read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] model [" << m_name
+ << "] old_pm_params [" << old_pm_params
+ << "] old_st_params [" << old_st_params[st]
+ << "] old_fit [" << old_fit
+ << "] crt_pm_params [" << crt_pm_params
+ << "] crt_st_params [" << crt_st_params[st]
+ << "] crt_fit [" << crt_fit
+ << "] round [" << round << "]" << endl;
+
+ if (done)
+ {
+ // singularity detected; stop
+ break;
+ }
+
+ if (crt_fit < old_fit)
+ {
+ LOG(info) << "scaling_regression read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] model [" << m_name
+ << "] old_pm_params [" << old_pm_params
+ << "] old_st_params [" << old_st_params[st]
+ << "] old_fit [" << old_fit
+ << "] crt_pm_params [" << crt_pm_params
+ << "] crt_st_params [" << crt_st_params[st]
+ << "] crt_fit [" << crt_fit
+ << "] round [" << round << "]" << endl;
+ crt_pm_params = old_pm_params;
+ crt_st_params = old_st_params;
+ crt_fit = old_fit;
+ break;
+ }
+
+ ++round;
+ // stop condition
+ if (round >= opts::scaling_max_rounds
+ or (round > 1 and crt_fit < old_fit + opts::scaling_min_progress))
+ {
+ break;
+ }
+
+ }; // while true
+ LOG(info)
+ << "scaling_result read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] model [" << m_name
+ << "] pm_params [" << crt_pm_params
+ << "] st_params [" << crt_st_params[st]
+ << "] fit [" << crt_fit
+ << "] rounds [" << round << "]" << endl;
+ } // for m_name
+ if (opts::scaling_select_threshold.get() < INFINITY)
+ {
+ auto it_max = alg::max_of(
+ model_fit,
+ [] (const decltype(model_fit)::value_type& p) { return p.second; });
+ if (alg::all_of(
+ model_fit,
+ [&] (const decltype(model_fit)::value_type& p) {
+ return &p == &*it_max
+ or p.second + opts::scaling_select_threshold.get() < it_max->second;
+ }))
+ {
+ read_summary.preferred_model[st][st] = it_max->first;
+ LOG(info)
+ << "selected_model read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] model [" << it_max->first << "]" << endl;
+ }
+ }
+ } // for st
+ } // if not scale_strands_together
+ read_summary.drop_events();
+ }, // process_item
+ // progress_report
+ [&] (unsigned items, unsigned seconds) {
+ clog << "Processed " << setw(6) << right << items << " reads in "
+ << setw(6) << right << seconds << " seconds\r";
+ }); // pfor
+ auto time_end_ms = get_cpu_time_ms();
+ LOG(info) << "training user_cpu_secs=" << (time_end_ms - time_start_ms)/1000 << endl;
+} // train_reads
+
+void write_fasta(ostream& os, const string& name, const string& seq)
+{
+ os << ">" << name << endl;
+ for (unsigned pos = 0; pos < seq.size(); pos += opts::fasta_line_width)
+ {
+ os << seq.substr(pos, opts::fasta_line_width) << endl;
+ }
+} // write_fasta
+
+void basecall_reads(const Pore_Model_Dict_Type& models,
+ const State_Transitions_Type& default_transitions,
+ deque< Fast5_Summary_Type >& reads)
+{
+ auto time_start_ms = get_cpu_time_ms();
+ strict_fstream::ofstream ofs;
+ ostream* os_p = nullptr;
+ if (not opts::output_fn.get().empty())
+ {
+ ofs.open(opts::output_fn);
+ os_p = &ofs;
+ }
+ else
+ {
+ os_p = &cout;
+ }
+
+ unsigned crt_idx = 0;
+ pfor::pfor< unsigned, ostringstream >(
+ opts::num_threads,
+ opts::chunk_size,
+ // get_item
+ [&] (unsigned& i) {
+ if (crt_idx >= reads.size()) return false;
+ i = crt_idx++;
+ return true;
+ },
+ // process_item
+ [&] (unsigned& i, ostringstream& oss) {
+ Fast5_Summary_Type& read_summary = reads[i];
+ if (read_summary.num_ed_events == 0) return;
+ global_assert::global_msg() = read_summary.read_id;
+ read_summary.load_events();
+
+ // compute read statistics used to check scaling
+ array< pair< FLOAT_TYPE, FLOAT_TYPE >, 2 > r_stats;
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ // if not enough events, ignore strand
+ if (read_summary.events(st).size() < opts::min_ed_events) continue;
+ r_stats[st] = alg::mean_stdv_of< FLOAT_TYPE >(
+ read_summary.events(st),
+ [] (const Event_Type& ev) { return ev.mean; });
+ LOG(debug)
+ << "mean_stdv read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] ev_mean=[" << r_stats[st].first
+ << "] ev_stdv=[" << r_stats[st].second << "]" << endl;
+ }
+
+ // basecalling functor
+ // returns: (path_prob, base_seq)
+ auto basecall_strand = [&] (unsigned st, string m_name,
+ const Pore_Model_Parameters_Type& pm_params,
+ const State_Transition_Parameters_Type& st_params) {
+ // scale model
+ Pore_Model_Type pm(models.at(m_name));
+ pm.scale(pm_params);
+ State_Transitions_Type custom_transitions;
+ const State_Transitions_Type* transitions_ptr;
+ if (not st_params.is_default())
+ {
+ custom_transitions.compute_transitions_fast(st_params);
+ transitions_ptr = &custom_transitions;
+ }
+ else
+ {
+ transitions_ptr = &default_transitions;
+ }
+ LOG(info)
+ << "basecalling read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] model [" << m_name
+ << "] pm_params [" << pm_params
+ << "] st_params [" << st_params << "]" << endl;
+ LOG(debug)
+ << "mean_stdv read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] model_mean [" << pm.mean()
+ << "] model_stdv [" << pm.stdv() << "]" << endl;
+ if (abs(r_stats[st].first - pm.mean()) > 5.0)
+ {
+ LOG(warning)
+ << "means_apart read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] model [" << m_name
+ << "] parameters [" << pm_params
+ << "] model_mean=[" << pm.mean()
+ << "] events_mean=[" << r_stats[st].first
+ << "]" << endl;
+ }
+ // correct drift
+ Event_Sequence_Type corrected_events = read_summary.events(st);
+ corrected_events.apply_drift_correction(pm_params.drift);
+ Viterbi_Type vit;
+ vit.fill(pm, *transitions_ptr, corrected_events);
+ return std::make_tuple(vit.path_probability(), std::move(corrected_events));
+ };
+
+ if (read_summary.scale_strands_together)
+ {
+ // create list of models to try
+ list< array< string, 2 > > model_sublist;
+ if (not read_summary.preferred_model[2][0].empty())
+ {
+ // if we have a preferred model, use that
+ model_sublist.push_back(read_summary.preferred_model[2]);
+ }
+ else
+ {
+ // no preferred model, try all for which we have scaling parameters
+ for (const auto& p : read_summary.pm_params_m)
+ {
+ if (p.first[0].empty() or p.first[1].empty()) continue;
+ model_sublist.push_back(p.first);
+ }
+ }
+ // basecall using applicable models
+ deque< tuple< FLOAT_TYPE,
+ FLOAT_TYPE, FLOAT_TYPE,
+ string, string,
+ Event_Sequence_Type, Event_Sequence_Type > > results;
+ for (const auto& m_name : model_sublist)
+ {
+ array< tuple< FLOAT_TYPE, Event_Sequence_Type >, 2 > part_results;
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ part_results[st] = basecall_strand(
+ st, m_name[st],
+ read_summary.pm_params_m.at(m_name),
+ read_summary.st_params_m.at(m_name)[st]);
+ }
+ results.emplace_back(get<0>(part_results[0]) + get<0>(part_results[1]),
+ get<0>(part_results[0]),
+ get<0>(part_results[1]),
+ string(m_name[0]),
+ string(m_name[1]),
+ std::move(get<1>(part_results[0])),
+ std::move(get<1>(part_results[1])));
+ }
+ // sort results by first component (log path probability)
+ sort(results.begin(),
+ results.end(),
+ [] (const decltype(results)::value_type& lhs, const decltype(results)::value_type& rhs) {
+ return get<0>(lhs) < get<0>(rhs);
+ });
+ array< FLOAT_TYPE, 2 > best_log_path_prob{{ get<1>(results.back()), get<2>(results.back()) }};
+ array< string, 2 > best_m_name{{ get<3>(results.back()), get<4>(results.back()) }};
+ array< const Event_Sequence_Type*, 2 > event_seq_ptr = {
+ &get<5>(results.back()),
+ &get<6>(results.back())
+ };
+ array< string, 2 > base_seq = {
+ get<5>(results.back()).get_base_seq(),
+ get<6>(results.back()).get_base_seq()
+ };
+ string best_m_name_str = best_m_name[0] + '+' + best_m_name[1];
+ auto& best_pm_params = read_summary.pm_params_m.at(best_m_name);
+ auto& best_st_params = read_summary.st_params_m.at(best_m_name);
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ LOG(info)
+ << "best_model read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] model [" << best_m_name[st]
+ << "] pm_params [" << best_pm_params
+ << "] st_params [" << best_st_params[st]
+ << "] log_path_prob [" << best_log_path_prob[st] << "]" << endl;
+ read_summary.preferred_model[st][st] = best_m_name[st];
+ read_summary.pm_params_m[read_summary.preferred_model[st]] = best_pm_params;
+ read_summary.st_params_m[read_summary.preferred_model[st]][st] = best_st_params[st];
+ string seq_name;
+ {
+ ostringstream tmp;
+ tmp << read_summary.read_id << ":" << read_summary.base_file_name << ":" << st;
+ seq_name = tmp.str();
+ }
+ if (opts::write_fast5)
+ {
+ read_summary.add_basecall_seq(seq_name, st, base_seq[st]);
+ read_summary.add_basecall_events(st, *event_seq_ptr[st]);
+ read_summary.add_basecall_model(st, models.at(best_m_name[st]));
+ read_summary.add_basecall_model_params(st, best_pm_params);
+ }
+ else
+ {
+ write_fasta(oss, seq_name, base_seq[st]);
+ }
+ }
+ }
+ else // not scale_strands_together
+ {
+ for (unsigned st = 0; st < 2; ++st)
+ {
+ // if not enough events, ignore strand
+ if (read_summary.events(st).size() < opts::min_ed_events) continue;
+ // create list of models to try
+ list< array< string, 2 > > model_sublist;
+ if (not read_summary.preferred_model[st][st].empty())
+ {
+ // if we have a preferred model, use that
+ model_sublist.push_back(read_summary.preferred_model[st]);
+ }
+ else
+ {
+ // no preferred model, try all for which we have scaling
+ for (const auto& p : read_summary.pm_params_m)
+ {
+ if (not p.first[st].empty() and p.first[1 - st].empty())
+ {
+ model_sublist.push_back(p.first);
+ }
+ }
+ }
+ // deque of results
+ deque< tuple< FLOAT_TYPE, string, Event_Sequence_Type > > results;
+ for (const auto& m_name : model_sublist)
+ {
+ auto r = basecall_strand(
+ st, m_name[st],
+ read_summary.pm_params_m.at(m_name),
+ read_summary.st_params_m.at(m_name)[st]);
+ results.emplace_back(get<0>(r),
+ string(m_name[st]),
+ std::move(get<1>(r)));
+ }
+ sort(results.begin(),
+ results.end(),
+ [] (const decltype(results)::value_type& lhs, const decltype(results)::value_type& rhs) {
+ return get<0>(lhs) < get<0>(rhs);
+ });
+ const string& best_m_name = get<1>(results.back());
+ const Event_Sequence_Type& event_seq = get<2>(results.back());
+ string base_seq = event_seq.get_base_seq();
+ array< string, 2 > best_m_key;
+ best_m_key[st] = best_m_name;
+ LOG(info)
+ << "best_model read [" << read_summary.read_id
+ << "] strand [" << st
+ << "] model [" << best_m_name
+ << "] pm_params [" << read_summary.pm_params_m.at(best_m_key)
+ << "] st_params [" << read_summary.st_params_m.at(best_m_key)[st]
+ << "] log_path_prob [" << get<0>(results.back()) << "]" << endl;
+ read_summary.preferred_model[st][st] = best_m_name;
+ string seq_name;
+ {
+ ostringstream tmp;
+ tmp << read_summary.read_id << ":" << read_summary.base_file_name << ":" << st;
+ seq_name = tmp.str();
+ }
+ if (opts::write_fast5)
+ {
+ read_summary.add_basecall_seq(seq_name, st, base_seq);
+ read_summary.add_basecall_events(st, event_seq);
+ read_summary.add_basecall_model(st, models.at(best_m_name));
+ read_summary.add_basecall_model_params(st, read_summary.pm_params_m.at(best_m_key));
+ }
+ else
+ {
+ write_fasta(oss, seq_name, base_seq);
+ }
+ } // for st
+ }
+ read_summary.drop_events();
+ },
+ // output_chunk
+ [&] (ostringstream& oss) {
+ *os_p << oss.str();
+ },
+ // progress_report
+ [&] (unsigned items, unsigned seconds) {
+ clog << "Processed " << setw(6) << right << items << " reads in "
+ << setw(6) << right << seconds << " seconds\r";
+ }); // pfor
+ auto time_end_ms = get_cpu_time_ms();
+ LOG(info) << "basecalling user_cpu_secs=" << (time_end_ms - time_start_ms)/1000 << endl;
+} // basecall_reads
+
+int real_main()
+{
+ Pore_Model_Dict_Type models;
+ State_Transitions_Type default_transitions;
+ deque< Fast5_Summary_Type > reads;
+ list< string > files;
+ // initialize structs
+ init_models(models);
+ init_transitions(default_transitions);
+ init_files(files);
+ init_reads(models, files, reads);
+ if (opts::train)
+ {
+ // do some training
+ train_reads(models, default_transitions, reads);
+ }
+ if (opts::basecall)
+ {
+ // basecall reads
+ basecall_reads(models, default_transitions, reads);
+ }
+ // print stats
+ if (not opts::stats_fn.get().empty())
+ {
+ strict_fstream::ofstream ofs(opts::stats_fn);
+ Fast5_Summary_Type::write_tsv_header(ofs);
+ ofs << endl;
+ for (const auto& s : reads)
+ {
+ s.write_tsv(ofs);
+ ofs << endl;
+ }
+ }
+ assert(fast5::File::get_object_count() == 0);
+ return EXIT_SUCCESS;
+}
+
+int main(int argc, char * argv[])
+{
+ opts::cmd_parser.parse(argc, argv);
+ logger::Logger::set_default_level(logger::level::info);
+ logger::Logger::set_levels_from_options(opts::log_level);
+ LOG(info) << "program: " << opts::cmd_parser.getProgramName() << endl;
+ LOG(info) << "version: " << opts::cmd_parser.getVersion() << endl;
+ LOG(info) << "args: " << opts::cmd_parser.getOrigArgv() << endl;
+ LOG(info) << "num_threads=" << opts::num_threads.get() << endl;
+#ifndef H5_HAVE_THREADSAFE
+ if (opts::num_threads > 1)
+ {
+ LOG(warning) << "enabled multi-threading with non-threadsafe HDF5: using experimental locking" << endl;
+ }
+#endif
+ State_Transition_Parameters_Type::default_p_stay() = opts::pr_stay;
+ State_Transition_Parameters_Type::default_p_skip() = opts::pr_skip;
+ Fast5_Summary_Type::min_ed_events() = opts::min_ed_events;
+ Fast5_Summary_Type::max_ed_events() = opts::max_ed_events;
+ Fast5_Summary_Type::eventdetection_group() = opts::ed_group;
+ LOG (info) << "eventdetection_group=" << (Fast5_Summary_Type::eventdetection_group().empty()
+ ? string("smallest")
+ : Fast5_Summary_Type::eventdetection_group()) << endl;
+ //
+ // set pore-related options
+ //
+ if (opts::pore.get() == "r9")
+ {
+ Fast5_Summary_Type::abasic_level_top_percent() = 1.0;
+ Fast5_Summary_Type::abasic_level_top_offset() = 0.0;
+ Fast5_Summary_Type::hairpin_island_window_size() = 10;
+ Fast5_Summary_Type::hairpin_island_window_load() = 5;
+ }
+ else if (opts::pore.get() == "r73")
+ {
+ Fast5_Summary_Type::abasic_level_top_percent() = 1.0;
+ Fast5_Summary_Type::abasic_level_top_offset() = 5.0;
+ Fast5_Summary_Type::hairpin_island_window_size() = 5;
+ Fast5_Summary_Type::hairpin_island_window_load() = 5;
+ }
+ else
+ {
+ LOG(error) << "unknown pore type: " << opts::pore.get() << endl;
+ return EXIT_FAILURE;
+ }
+ LOG(info)
+ << "hairpin_detection:"
+ << " abasic_level_top_percent=" << Fast5_Summary_Type::abasic_level_top_percent()
+ << " abasic_level_top_offset=" << Fast5_Summary_Type::abasic_level_top_offset()
+ << " hairpin_island_window_size=" << Fast5_Summary_Type::hairpin_island_window_size()
+ << " hairpin_island_window_load=" << Fast5_Summary_Type::hairpin_island_window_load()
+ << endl;
+ //
+ // set training option
+ //
+ if (opts::train and opts::no_train)
+ {
+ LOG(error)
+ << "either --train or --no-train may be used, but not both" << endl;
+ return EXIT_FAILURE;
+ }
+ else if (not opts::train and not opts::no_train)
+ {
+ // by default, enable training
+ opts::train.set(true);
+ }
+ ASSERT(opts::train != opts::no_train);
+ //
+ // set basecalling option
+ //
+ if (opts::basecall and opts::no_basecall)
+ {
+ LOG(error)
+ << "either --basecall or --no-basecall may be used, but not both" << endl;
+ return EXIT_FAILURE;
+ }
+ else if (not opts::basecall and not opts::no_basecall)
+ {
+ // by default, enable basecalling
+ opts::basecall.set(true);
+ }
+ ASSERT(opts::basecall != opts::no_basecall);
+ //
+ // set single/double strand scaling option
+ //
+ if (opts::train and not opts::no_train_scaling)
+ {
+ if (opts::single_strand_scaling and opts::double_strand_scaling)
+ {
+ LOG(error)
+ << "either --single-strand-scaling or --double-strand-scaling may be used, but not both" << endl;
+ return EXIT_FAILURE;
+ }
+ else if (not opts::single_strand_scaling and not opts::double_strand_scaling)
+ {
+ // by default, do double strand scaling
+ opts::double_strand_scaling.set(true);
+ }
+ }
+ //
+ // check other options
+ //
+ if (opts::scaling_select_threshold.get() < 0.0)
+ {
+ LOG(error)
+ << "invalid scaling_select_threshold: " << opts::scaling_select_threshold.get() << endl;
+ return EXIT_FAILURE;
+ }
+ if (opts::scaling_min_progress < 0.0)
+ {
+ LOG(error)
+ << "invalid scaling_min_progress: " << opts::scaling_min_progress.get() << endl;
+ return EXIT_FAILURE;
+ }
+ if (not opts::output_fn.get().empty() and opts::write_fast5)
+ {
+ LOG(error)
+ << "output may be written to fast5 files or to a single output file, but not both" << endl;
+ return EXIT_FAILURE;
+ }
+ //
+ // print training options
+ //
+ LOG(info) << "train=" << opts::train.get() << endl;
+ if (opts::train)
+ {
+ LOG(info) << "train_scaling=" << not opts::no_train_scaling.get() << endl;
+ LOG(info) << "train_transitions=" << not opts::no_train_transitions.get() << endl;
+ if (not opts::no_train_scaling)
+ {
+ LOG(info) << "double_strands_scaling=" << opts::double_strand_scaling.get() << endl;
+ LOG(info) << "scaling_num_events=" << opts::scaling_num_events.get() << endl;
+ LOG(info) << "scaling_max_rounds=" << opts::scaling_max_rounds.get() << endl;
+ LOG(info) << "scaling_min_progress=" << opts::scaling_min_progress.get() << endl;
+ LOG(info) << "scaling_select_threshold=" << opts::scaling_select_threshold.get() << endl;
+ }
+ }
+ LOG(info) << "basecall=" << opts::basecall.get() << endl;
+ return real_main();
+}
diff --git a/src/nanocall/run-fwbw.cpp b/src/nanocall/run-fwbw.cpp
new file mode 100644
index 0000000..24268de
--- /dev/null
+++ b/src/nanocall/run-fwbw.cpp
@@ -0,0 +1,101 @@
+#include <iostream>
+#include <string>
+#include <tclap/CmdLine.h>
+
+#include "Pore_Model.hpp"
+#include "State_Transitions.hpp"
+#include "Event.hpp"
+#include "Forward_Backward.hpp"
+#include "Forward_Backward_Custom.hpp"
+#include "logger.hpp"
+#include "zstr.hpp"
+
+using namespace std;
+
+#ifndef FLOAT_TYPE
+#define FLOAT_TYPE float
+#endif
+#ifndef KMER_SIZE
+#define KMER_SIZE 6
+#endif
+typedef State_Transitions< FLOAT_TYPE, KMER_SIZE > State_Transitions_Type;
+typedef Pore_Model< FLOAT_TYPE, KMER_SIZE > Pore_Model_Type;
+typedef Event< FLOAT_TYPE, KMER_SIZE> Event_Type;
+typedef Event_Sequence< FLOAT_TYPE, KMER_SIZE > Event_Sequence_Type;
+typedef Forward_Backward< FLOAT_TYPE, KMER_SIZE > Forward_Backward_Type;
+typedef Forward_Backward_Custom< FLOAT_TYPE, KMER_SIZE > Forward_Backward_Custom_Type;
+
+namespace opts
+{
+ using namespace TCLAP;
+ string description =
+ "Given a scaled pore model, a state trasition table, and a sequence of events, "
+ "compute the state distribution conditioned on the prefix event sequence";
+ CmdLine cmd_parser(description);
+ MultiArg< string > log_level("d", "log-level", "Log level.", false, "string", cmd_parser);
+ ValueArg< string > pm_file_name("p", "pore-model", "Scaled pore model file name.", true, "", "file", cmd_parser);
+ ValueArg< string > st_file_name("s", "state-transitions", "State transitions file name.", true, "", "file", cmd_parser);
+ ValueArg< string > ev_file_name("e", "events", "Events file name.", true, "", "file", cmd_parser);
+ ValueArg< string > output_file_name("o", "output", "Output file name.", false, "", "file", cmd_parser);
+ SwitchArg custom_fwbw("", "custom-fwbw", "Use custom fwbw.", cmd_parser);
+} // namespace opts
+
+void real_main()
+{
+ Pore_Model_Type pm;
+ //Pore_Model_Parameters<> params;
+ State_Transitions_Type st;
+ Event_Sequence_Type ev;
+ zstr::ifstream(opts::pm_file_name) >> pm;
+ zstr::ifstream(opts::st_file_name) >> st;
+ {
+ zstr::ifstream ifs(opts::ev_file_name);
+ Event_Type e;
+ while (ifs >> e)
+ {
+ ev.push_back(e);
+ }
+ }
+
+ Forward_Backward_Type fwbw;
+ Forward_Backward_Custom_Type fwbw_custom;
+ if (not opts::custom_fwbw)
+ {
+ fwbw.fill(pm, st, ev);
+ }
+ else
+ {
+ fwbw_custom.fill(pm, st, ev);
+ }
+
+ // print all kmers with posterior >= .1 for the middle event
+ multiset< pair< FLOAT_TYPE, unsigned > > s;
+ for (unsigned j = 0; j < pm.n_states; ++j)
+ {
+ FLOAT_TYPE v = exp(not opts::custom_fwbw
+ ? fwbw.log_posterior(ev.size() / 2, j)
+ : fwbw_custom.log_posterior(ev.size() / 2, j));
+ if (v >= .1)
+ {
+ s.insert(make_pair(v, j));
+ }
+ }
+ while (not s.empty())
+ {
+ auto it = prev(s.end());
+ cout << Forward_Backward_Type::Kmer_Type::to_string(it->second) << '\t' << it->first << endl;
+ s.erase(it);
+ }
+
+ if (not opts::output_file_name.get().empty())
+ {
+ strict_fstream::ofstream(opts::output_file_name) << fwbw;
+ }
+}
+
+int main(int argc, char * argv[])
+{
+ opts::cmd_parser.parse(argc, argv);
+ logger::Logger::set_levels_from_options(opts::log_level);
+ real_main();
+}
diff --git a/src/nanocall/run-viterbi.cpp b/src/nanocall/run-viterbi.cpp
new file mode 100644
index 0000000..b6c9528
--- /dev/null
+++ b/src/nanocall/run-viterbi.cpp
@@ -0,0 +1,64 @@
+#include <iostream>
+#include <string>
+#include <tclap/CmdLine.h>
+
+#include "Pore_Model.hpp"
+#include "State_Transitions.hpp"
+#include "Event.hpp"
+#include "Viterbi.hpp"
+#include "logger.hpp"
+#include "zstr.hpp"
+
+using namespace std;
+
+#ifndef FLOAT_TYPE
+#define FLOAT_TYPE float
+#endif
+#ifndef KMER_SIZE
+#define KMER_SIZE 6
+#endif
+typedef State_Transitions< FLOAT_TYPE, KMER_SIZE > State_Transitions_Type;
+typedef Pore_Model< FLOAT_TYPE, KMER_SIZE > Pore_Model_Type;
+typedef Event< FLOAT_TYPE, KMER_SIZE > Event_Type;
+typedef Event_Sequence< FLOAT_TYPE, KMER_SIZE > Event_Sequence_Type;
+typedef Viterbi< FLOAT_TYPE, KMER_SIZE > Viterbi_Type;
+
+namespace opts
+{
+ using namespace TCLAP;
+ string description =
+ "Run Viterbi on given input";
+ CmdLine cmd_parser(description);
+ MultiArg< string > log_level("d", "log-level", "Log level.", false, "string", cmd_parser);
+ ValueArg< string > pm_file_name("p", "pore-model", "Scaled pore model file name.", true, "", "file", cmd_parser);
+ ValueArg< string > st_file_name("s", "state-transitions", "State transitions file name.", true, "", "file", cmd_parser);
+ ValueArg< string > ev_file_name("e", "events", "Events file name.", true, "", "file", cmd_parser);
+} // namespace opts
+
+void real_main()
+{
+ Pore_Model_Type pm;
+ State_Transitions_Type st;
+ Event_Sequence_Type ev;
+ zstr::ifstream(opts::pm_file_name) >> pm;
+ zstr::ifstream(opts::st_file_name) >> st;
+ {
+ zstr::ifstream ifs(opts::ev_file_name);
+ Event_Type e;
+ while (ifs >> e)
+ {
+ ev.push_back(e);
+ }
+ }
+
+ Viterbi_Type vit;
+ vit.fill(pm, st, ev);
+ cout << ev.get_base_seq() << std::endl;
+}
+
+int main(int argc, char * argv[])
+{
+ opts::cmd_parser.parse(argc, argv);
+ logger::Logger::set_levels_from_options(opts::log_level);
+ real_main();
+}
diff --git a/src/version/CMakeLists.txt b/src/version/CMakeLists.txt
new file mode 100644
index 0000000..96424ee
--- /dev/null
+++ b/src/version/CMakeLists.txt
@@ -0,0 +1,4 @@
+message(STATUS "Processing: ${CMAKE_CURRENT_SOURCE_DIR}")
+
+add_library(version STATIC version.cpp)
+add_dependencies(version package_version)
diff --git a/src/version/version.cpp b/src/version/version.cpp
new file mode 100644
index 0000000..57f3728
--- /dev/null
+++ b/src/version/version.cpp
@@ -0,0 +1,4 @@
+#include "version.hpp"
+#include "package_version.h"
+
+char const * const package_version = PACKAGE_VERSION;
diff --git a/src/version/version.hpp b/src/version/version.hpp
new file mode 100644
index 0000000..ae31f62
--- /dev/null
+++ b/src/version/version.hpp
@@ -0,0 +1,6 @@
+#ifndef __VERSION_HPP
+#define __VERSION_HPP
+
+extern char const * const package_version;
+
+#endif
--
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