[med-svn] [Git][med-team/constellations][upstream] New upstream version 0.1.12

Andreas Tille (@tille) gitlab at salsa.debian.org
Tue Aug 22 19:27:26 BST 2023



Andreas Tille pushed to branch upstream at Debian Med / constellations


Commits:
b5559d69 by Andreas Tille at 2023-08-22T16:38:15+02:00
New upstream version 0.1.12
- - - - -


23 changed files:

- constellations/__init__.py
- constellations/definitions/cA.23.1+E484K.json
- constellations/definitions/cAV1.json
- constellations/definitions/cAY.4.2.json
- constellations/definitions/cB.1.1.318.json
- constellations/definitions/cB.1.1.529.json
- constellations/definitions/cB.1.525.json
- constellations/definitions/cB.1.617.1.json
- constellations/definitions/cB.1.617.3.json
- constellations/definitions/cBA.1.json
- constellations/definitions/cBA.2.json
- constellations/definitions/cBA.4.json
- constellations/definitions/cBA.5.json
- constellations/definitions/cC.37.json
- constellations/definitions/cP.2.json
- constellations/definitions/cP.3.json
- + constellations/definitions/cXBB-parent1.json
- + constellations/definitions/cXBB-parent2.json
- + constellations/definitions/cXBB.1.16.json
- + constellations/definitions/cXBB.1.5.json
- + constellations/definitions/cXBB.1.json
- + constellations/definitions/cXBB.json
- constellations/definitions/cXE.json


Changes:

=====================================
constellations/__init__.py
=====================================
@@ -1,3 +1,3 @@
 _program = "constellations"
-__version__ = "v0.1.10"
+__version__ = "v0.1.12"
 


=====================================
constellations/definitions/cA.23.1+E484K.json
=====================================
@@ -9,14 +9,15 @@
         "Pango_lineages": [
             "A.23.1"
         ],
-	    "mrca_lineage": "A.23.1",
-        "PHE_label": "VUI-21FEB-01",
+        "mrca_lineage": "A.23.1",
+        "PHE_label": "V-21FEB-01",
         "representative_genome": ""
     },
     "tags": [
         "A.23.1",
         "VUI-21FEB-01",
-        "VUI202102/01"
+        "VUI202102/01",
+        "V-21FEB-01"
     ],
     "sites": [
         "nsp3:L741F",


=====================================
constellations/definitions/cAV1.json
=====================================
@@ -9,11 +9,12 @@
 			"AV.1"
 		],
 		"mrca_lineage": "AV.1",
-		"PHE_label": "VOC-20-DEC-01",
+		"PHE_label": "VOC-20DEC-01",
 		"representative_genome": ""
 	},
 	"tags": [
-		"AV.1"
+		"AV.1",
+		"VOC-20DEC-01"
 	],
 	"sites": [
 		"s:D80G",


=====================================
constellations/definitions/cAY.4.2.json
=====================================
@@ -6,16 +6,17 @@
     "type": "variant",
     "variant": {
 	"Pango_lineages": [
-	    "AY.4.2"
+        "AY.4.2"
 	],
 	"mrca_lineage": "AY.4.2",
         "lineage_name": "AY.4.2",
         "parent_lineage": "AY.4",
-	"PHE_label": "VUI-21OCT-01",
+	"PHE_label": "V-21OCT-01",
 	"representative_genome": ""
     },
     "tags": [
-	"AY.4.2"
+	"AY.4.2",
+    "V-21OCT-01"
     ],
     "sites": [
         "nuc:T17040C",


=====================================
constellations/definitions/cB.1.1.318.json
=====================================
@@ -9,14 +9,15 @@
 		"Pango_lineages": [
 			"B.1.1.318"        
 		],
-	    "mrca_lineage": "B.1.1.318",
-		"PHE_label": "VUI-21FEB-04",
+        "mrca_lineage": "B.1.1.318",
+		"PHE_label": "V-21FEB-04",
 		"representative_genome": ""
     },
 	"tags": [
 		"B.1.1.318",
 		"VUI-21FEB-04",
-		"VUI202102/04"
+		"VUI202102/04",
+        "V-21FEB-04"
 	],
     "sites": [
         "nuc:C3961T",


=====================================
constellations/definitions/cB.1.1.529.json
=====================================
@@ -28,7 +28,6 @@
         "spike:G339D",
         "spike:S373P",
         "spike:S375F",
-        "spike:K417N",
         "spike:N440K",
         "spike:S477N",
         "spike:T478K",
@@ -57,7 +56,7 @@
     "rules": {
       "default": {
         "min_alt": 22,
-        "max_ref": 2,
+        "max_ref": 3,
         "spike:D614G": "not ref"
       },
       "Probable": {


=====================================
constellations/definitions/cB.1.525.json
=====================================
@@ -9,8 +9,8 @@
         "Pango_lineages": [
             "B.1.525"
         ],
-	    "mrca_lineage": "B.1.525",
-        "PHE_label": "VUI-21FEB-03",
+        "mrca_lineage": "B.1.525",
+        "PHE_label": "V-21FEB-03",
         "WHO_label": "Eta",
         "representative_genome": ""
     },
@@ -20,7 +20,8 @@
         "VUI202102/03",
         "Eta",
         "G/484K.V3",
-        "20A"
+        "20A",
+        "V-21FEB-03"
     ],
     "sites": [
         "nuc:C1498T",


=====================================
constellations/definitions/cB.1.617.1.json
=====================================
@@ -10,13 +10,14 @@
         "Pango_lineages": [
             "B.1.617.1"
         ],
-	    "mrca_lineage": "B.1.617.1",
-        "PHE_label": "VUI-21APR-01",
+        "mrca_lineage": "B.1.617.1",
+        "PHE_label": "V-21APR-01",
         "representative_genome": ""
     },
     "tags": [
         "B.1.617.1",
-        "VUI-21APR-01"
+        "VUI-21APR-01",
+        "V-21APR-01"
     ],
     "sites": [
         "nuc:C3457T",


=====================================
constellations/definitions/cB.1.617.3.json
=====================================
@@ -10,12 +10,13 @@
             "B.1.617.3"
         ],
 	    "mrca_lineage": "B.1.617.3",
-        "PHE_label": "VUI-21APR-03",
+        "PHE_label": "V-21APR-03",
         "representative_genome": ""
     },
     "tags": [
         "B.1.617.3",
-        "VUI-21APR-03"
+        "VUI-21APR-03",
+        "V-21APR-03"
     ],
     "sites": [
         "nuc:C835T",


=====================================
constellations/definitions/cBA.1.json
=====================================
@@ -9,13 +9,15 @@
             "BA.1"
         ],
         "WHO_label": "Omicron",
-	"mrca_lineage": "BA.1",
+        "mrca_lineage": "BA.1",
         "lineage_name": "BA.1",
         "parent_lineage": "B.1.1.529",
+        "PHE_label": "VOC-21NOV-01",
         "representative_genome": ""
     },
     "tags": [
-        "BA.1"
+        "BA.1",
+        "VOC-21NOV-01"
     ],
     "sites": [
         "orf1ab:K856R",


=====================================
constellations/definitions/cBA.2.json
=====================================
@@ -9,17 +9,19 @@
             "BA.2"
         ],
         "WHO_label": "Omicron",
-	"mrca_lineage": "BA.2",
+        "mrca_lineage": "BA.2",
         "lineage_name": "BA.2",
         "parent_lineage": "B.1.1.529",
+        "PHE_label": "VOC-22JAN-01",
         "representative_genome": ""
     },
     "tags": [
-        "BA.2"
+        "BA.2",
+        "VOC-22JAN-01"
     ],
     "sites": [
         "orf1ab:S135R",
-	"orf1ab:T842I",
+	    "orf1ab:T842I",
         "orf1ab:G1307S",
         "nuc:C4321T",
         "orf1ab:L3027F",
@@ -36,15 +38,14 @@
         "nuc:A20055G",
         "spike:T19I",
         "del:21633:9",
-        "nuc:T22200G",
+        "spike:V213G",
         "spike:S371F",
         "spike:T376A",
         "spike:D405N",
-        "spike:R408S",
         "spike:Q493R",
+        "orf3a:T223I",
         "nuc:C25000T",
         "nuc:C25584T",
-        "nuc:C26060T",
         "nuc:C26858T",
         "orf6:D61L",
         "n:RG203KR",
@@ -53,11 +54,8 @@
     "note": "Unique mutations for sublineage",
     "rules": {
       "default": {
-        "min_alt": 27,
-        "max_ref": 3,
-        "spike:Q493":"alt",
-        "n:P151":"ref",
-        "nuc:G27788":"ref"
+        "min_alt": 23,
+        "max_ref": 4
       }
     }
 }


=====================================
constellations/definitions/cBA.4.json
=====================================
@@ -12,10 +12,12 @@
 	      "mrca_lineage": "BA.4",
         "lineage_name": "BA.4",
         "parent_lineage": "B.1.1.529",
+        "PHE_label": "V-22APR-03",
         "representative_genome": ""
     },
     "tags": [
-        "BA.4"
+        "BA.4",
+        "V-22APR-03"
     ],
     "sites": [
       "orf1ab:S135R",


=====================================
constellations/definitions/cBA.5.json
=====================================
@@ -9,13 +9,15 @@
             "BA.5"
         ],
         "WHO_label": "Omicron",
-	      "mrca_lineage": "BA.5",
+        "mrca_lineage": "BA.5",
         "lineage_name": "BA.5",
         "parent_lineage": "B.1.1.529",
+        "PHE_label": "V-22APR-04",
         "representative_genome": ""
     },
     "tags": [
-        "BA.5"
+        "BA.5",
+        "V-22APR-04"
     ],
     "sites": [
       "orf1ab:S135R",
@@ -50,8 +52,8 @@
     "note": "Unique mutations for sublineage",
     "rules": {
       "default": {
-        "min_alt": 27,
-        "max_ref": 5,
+        "min_alt": 25,
+        "max_ref": 4,
         "s:Q493":"ref",
         "nuc:C26858":"ref",
         "nuc:G27788":"ref",


=====================================
constellations/definitions/cC.37.json
=====================================
@@ -10,11 +10,13 @@
         ],
 	    "mrca_lineage": "C.37",
 	    "WHO_label": "Lambda",
+		"PHE_label": "V-21JUN-01",
         "representative_genome": ""
     },
     "tags": [
         "Lambda",
-        "C.37"
+        "C.37",
+		"V-21JUN-01"
     ],
     "sites": [
 		"ORF1a:T1246I",


=====================================
constellations/definitions/cP.2.json
=====================================
@@ -10,14 +10,15 @@
             "P.2"
         ],
 	    "mrca_lineage": "P.2",
-        "PHE_label": "VUI-21JAN-01",
+        "PHE_label": "V-21JAN-01",
         "WHO_label": "Zeta",
         "representative_genome": ""
     },
     "tags": [
         "P.2",
         "VUI-21JAN-01",
-        "VUI202101/01"
+        "VUI202101/01",
+        "V-21JAN-01"
     ],
     "sites": [
         "ORF1ab:L205V",


=====================================
constellations/definitions/cP.3.json
=====================================
@@ -10,15 +10,16 @@
         "Pango_lineages": [
             "P.3"
         ],
-	    "mrca_lineage": "P.3",
-        "PHE_label": "VUI-21MAR-02",
+        "mrca_lineage": "P.3",
+        "PHE_label": "V-21MAR-02",
         "WHO_label": "Theta",
         "representative_genome": ""
     },
     "tags": [
         "P.3",
         "VUI-21MAR-02",
-        "VUI202103/02"
+        "VUI202103/02",
+        "V-21MAR-02"
     ],
     "sites": [
         "nsp3:D736G",


=====================================
constellations/definitions/cXBB-parent1.json
=====================================
@@ -0,0 +1,31 @@
+{
+    "label": "XBB-parent1",
+    "description": "Majority parent of XBB recombinant lineage",
+    "sources": [
+    ],
+    "type": "variant",
+    "variant": {
+	"mrca_lineage": "",
+        "lineage_name": "XBB-parent1",
+	    "parent_lineage": "BA.2",
+        "representative_genome": ""
+    },
+    "tags": [
+        "XBB"
+    ],
+    "note": "Shared mutations with BA.2.75 parent",
+    "note": "Likely breakpoint: ~ S:446",
+    "sites": [
+        "spike:G339H",
+        "spike:G446S",
+        "spike:N460K",
+        "e:T11A",
+        "nuc:C25416T"
+    ],
+    "rules": {
+      "default": {
+        "min_alt": 2,
+        "max_ref": 2
+      }
+    }
+}


=====================================
constellations/definitions/cXBB-parent2.json
=====================================
@@ -0,0 +1,27 @@
+{
+    "label": "XBB-parent2",
+    "description": "Minority parent of XBB recombinant lineage",
+    "sources": [
+    ],
+    "type": "variant",
+    "variant": {
+	"mrca_lineage": "",
+        "lineage_name": "XBB-parent2",
+	    "parent_lineage": "XBB-parent1",
+        "representative_genome": ""
+    },
+    "tags": [
+        "XBB"
+    ],
+    "note": "Shared mutations with BA.2.10.1 parent",
+    "note": "Likely breakpoint: ~ S:446",
+    "sites": [
+        "orf1b:S959P"
+    ],
+    "rules": {
+      "default": {
+        "min_alt": 0,
+        "max_ref": 1
+      }
+    }
+}


=====================================
constellations/definitions/cXBB.1.16.json
=====================================
@@ -0,0 +1,32 @@
+{
+    "label": "Omicron (XBB.1.16-like)",
+    "description": "XBB.1.16 lineage defining mutations",
+    "sources": [
+    ],
+    "type": "variant",
+    "variant": {
+        "Pango_lineages": [
+            "XBB.1.16"
+        ],
+        "WHO_label": "Omicron",
+        "parent_lineage": "XBB.1",
+        "mrca_lineage": "XBB.1.16",
+        "lineage_name": "XBB.1.16",
+        "representative_genome": ""
+    },
+    "tags": [
+        "XBB.1.16"
+    ],
+    "note": "Unique mutations for XBB.1.16 sublineage",
+    "sites": [
+        "orf1b:D1746Y",
+        "spike:E180V",
+        "nuc:T28297C",
+        "nuc:A28447G",
+        "nuc:C29386T"
+    ],
+    "rules": {
+        "min_alt": 3,
+        "max_ref": 1
+    }
+}


=====================================
constellations/definitions/cXBB.1.5.json
=====================================
@@ -0,0 +1,31 @@
+{
+    "label": "Omicron (XBB.1.5-like)",
+    "description": "XBB.1.5 lineage defining mutations",
+    "sources": [
+    ],
+    "type": "variant",
+    "variant": {
+        "Pango_lineages": [
+            "XBB.1.5"
+        ],
+        "WHO_label": "Omicron",
+        "parent_lineage": "XBB.1",
+        "mrca_lineage": "XBB.1.5",
+        "lineage_name": "XBB.1.5",
+        "representative_genome": ""
+    },
+    "tags": [
+        "XBB.1.5"
+    ],
+    "note": "Unique mutations for XBB.1.5 sublineage",
+    "sites": [
+        "nuc:T17124C",
+        "spike:G252V",
+        "spike:F486P"
+    ],
+    "rules": {
+        "min_alt": 2,
+        "max_ref": 0,
+        "spike:F486":"alt"
+    }
+}


=====================================
constellations/definitions/cXBB.1.json
=====================================
@@ -0,0 +1,30 @@
+{
+    "label": "Omicron (XBB.1-like)",
+    "description": "XBB.1 lineage defining mutations",
+    "sources": [
+    ],
+    "type": "variant",
+    "variant": {
+        "Pango_lineages": [
+            "XBB.1"
+        ],
+        "WHO_label": "Omicron",
+        "parent_lineage": "XBB",
+        "mrca_lineage": "XBB.1",
+        "lineage_name": "XBB.1",
+        "representative_genome": ""
+    },
+    "tags": [
+        "XBB.1"
+    ],
+    "note": "Unique mutations for XBB.1 sublineage",
+    "sites": [
+        "spike:R408S",
+        "spike:K417N",
+        "orf8:G8*"
+    ],
+    "rules": {
+        "min_alt": 2,
+        "max_ref": 0
+    }
+}


=====================================
constellations/definitions/cXBB.json
=====================================
@@ -0,0 +1,41 @@
+{
+    "label": "Omicron (XBB-like)",
+    "description": "XBB recombinant lineage defining mutations",
+    "sources": [
+    ],
+    "type": "variant",
+    "variant": {
+        "Pango_lineages": [
+            "XBB"
+        ],
+        "WHO_label": "Omicron",
+        "parent_lineage": "XBB-parent2",
+        "mrca_lineage": "XBB",
+        "lineage_name": "XBB",
+        "representative_genome": ""
+    },
+    "tags": [
+        "XBB"
+    ],
+    "note": "Unique mutations for XBB sublineage",
+    "sites": [
+        "spike:V83A",
+        "spike:Y144-",
+        "spike:H146Q",
+        "spike:Q183E",
+        "spike:V213E",
+        "spike:R346T",
+        "spike:L368I",
+        "spike:V445P",
+        "spike:F486S",
+        "spike:F490S",
+
+        "nuc:C15738T",
+        "nuc:T15939C",
+        "nuc:T17859C"
+    ],
+    "rules": {
+        "min_alt": 5,
+        "max_ref": 3
+    }
+}


=====================================
constellations/definitions/cXE.json
=====================================
@@ -9,14 +9,16 @@
             "XE"
         ],
         "WHO_label": "Omicron",
-	"parent_lineage": "XE-parent2",
-	"mrca_lineage": "XE",
+        "parent_lineage": "XE-parent2",
+        "mrca_lineage": "XE",
+        "PHE_label": "V-22APR-02",
         "lineage_name": "XE",
         "representative_genome": ""
     },
     "tags": [
         "XE",
-        "GL2"
+        "GL2",
+        "V-22APR-02"
     ],
     "note": "Unique mutations for XE sublineage",
     "sites": [
@@ -28,7 +30,7 @@
     "nuc:C14599T"
     ],
     "rules": {
-        "min_alt": 2,
+        "min_alt": 3,
         "max_ref": 0
     }
 }



View it on GitLab: https://salsa.debian.org/med-team/constellations/-/commit/b5559d69cd86694b163e85a088cf54fb0ffa7e5c

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