[Debian-med-packaging] Bug#1011968: spades: autopkgtest regression

Paul Gevers elbrus at debian.org
Sat May 28 06:27:31 BST 2022


Source: spades
Version: 3.15.4+dfsg-2
Severity: serious
User: debian-ci at lists.debian.org
Usertags: regression

Dear maintainer(s),

With a recent upload of spades the autopkgtest of spades fails in 
testing when that autopkgtest is run with the binary packages of spades 
from unstable. It passes when run with only packages from testing. In 
tabular form:

                        pass            fail
spades                 from testing    3.15.4+dfsg-2
all others             from testing    from testing

I copied some of the output at the bottom of this report.

Currently this regression is blocking the migration to testing [1]. Can 
you please investigate the situation and fix it?

More information about this bug and the reason for filing it can be found on
https://wiki.debian.org/ContinuousIntegration/RegressionEmailInformation

Paul

[1] https://qa.debian.org/excuses.php?package=spades

https://ci.debian.net/data/autopkgtest/testing/amd64/s/spades/22180185/log.gz



== Warning ==  No assembly mode was specified! If you intend to assemble 
high-coverage multi-cell/isolate data, use '--isolate' option.


Command line: /usr/libexec/spades/spades.py	--test	

System information:
   SPAdes version: 3.15.4
   Python version: 3.10.4
   OS: Linux-5.10.0-14-amd64-x86_64-with-glibc2.33

Output dir: /tmp/tmp.Kw3upbPyKH/spades_test
Mode: read error correction and assembling
Debug mode is turned OFF

Dataset parameters:
   Standard mode
   For multi-cell/isolate data we recommend to use '--isolate' option; 
for single-cell MDA data use '--sc'; for metagenomic data use '--meta'; 
for RNA-Seq use '--rna'.
   Reads:
     Library number: 1, library type: paired-end
       orientation: fr
       left reads: ['/usr/share/spades/test_dataset/ecoli_1K_1.fq.gz']
       right reads: ['/usr/share/spades/test_dataset/ecoli_1K_2.fq.gz']
       interlaced reads: not specified
       single reads: not specified
       merged reads: not specified
Read error correction parameters:
   Iterations: 1
   PHRED offset will be auto-detected
   Corrected reads will be compressed
Assembly parameters:
   k: automatic selection based on read length
   Repeat resolution is enabled
   Mismatch careful mode is turned OFF
   MismatchCorrector will be SKIPPED
   Coverage cutoff is turned OFF
Other parameters:
   Dir for temp files: /tmp/tmp.Kw3upbPyKH/spades_test/tmp
   Threads: 16
   Memory limit (in Gb): 250


======= SPAdes pipeline started. Log can be found here: 
/tmp/tmp.Kw3upbPyKH/spades_test/spades.log

/usr/share/spades/test_dataset/ecoli_1K_1.fq.gz: max reads length: 100
/usr/share/spades/test_dataset/ecoli_1K_2.fq.gz: max reads length: 100

Reads length: 100


===== Before start started.

===== Read error correction started.

===== Read error correction started.

== Running: /usr/libexec/spades/spades-hammer 
/tmp/tmp.Kw3upbPyKH/spades_test/corrected/configs/config.info

   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  :  75)   Starting BayesHammer, built from N/A, git 
revision N/A
   0:00:00.034     1M / 16M   INFO    General                 (main.cpp 
                  :  76)   Loading config from 
/tmp/tmp.Kw3upbPyKH/spades_test/corrected/configs/config.info
   0:00:00.066     1M / 16M   INFO    General                 (main.cpp 
                  :  78)   Maximum # of threads to use (adjusted due to 
OMP capabilities): 16
   0:00:00.082     1M / 16M   INFO    General 
(memory_limit.cpp          :  54)   Memory limit set to 250 Gb
   0:00:00.082     1M / 16M   INFO    General                 (main.cpp 
                  :  86)   Trying to determine PHRED offset
   0:00:00.083     1M / 16M   INFO    General                 (main.cpp 
                  :  92)   Determined value is 33
   0:00:00.083     1M / 16M   INFO    General 
(hammer_tools.cpp          :  38)   Hamming graph threshold tau=1, k=21, 
subkmer positions = [ 0 10 ]
   0:00:00.083     1M / 16M   INFO    General                 (main.cpp 
                  : 113)   Size of aux. kmer data 24 bytes
      === ITERATION 0 begins ===
   0:00:00.083     1M / 16M   INFO    General 
(kmer_index_builder.hpp    : 243)   Splitting kmer instances into 16 
files using 16 threads. This might take a while.
   0:00:00.083     1M / 16M   INFO    General 
(file_limit.hpp            :  42)   Open file limit set to 1024
   0:00:00.083     1M / 16M   INFO    General 
(kmer_splitter.hpp         :  93)   Memory available for splitting 
buffers: 5.20833 Gb
   0:00:00.083     1M / 16M   INFO    General 
(kmer_splitter.hpp         : 101)   Using cell size of 4194304
   0:00:00.222  9217M / 9217M INFO   K-mer Splitting 
(kmer_data.cpp             :  97)   Processing 
/usr/share/spades/test_dataset/ecoli_1K_1.fq.gz
   0:00:00.238  9217M / 9217M INFO   K-mer Splitting 
(kmer_data.cpp             :  97)   Processing 
/usr/share/spades/test_dataset/ecoli_1K_2.fq.gz
   0:00:00.250  9217M / 9217M INFO   K-mer Splitting 
(kmer_data.cpp             : 112)   Total 4108 reads processed
   0:00:00.250     1M / 568M  INFO    General 
(kmer_index_builder.hpp    : 249)   Starting k-mer counting.
   0:00:00.257     1M / 568M  INFO    General 
(kmer_index_builder.hpp    : 260)   K-mer counting done. There are 1974 
kmers in total.
   0:00:00.257     1M / 568M  INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:00.259     1M / 568M  INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 1974 kmers, 13944 
bytes occupied (56.5106 bits per kmer).
   0:00:00.259     1M / 568M  INFO   K-mer Counting 
(kmer_data.cpp             : 354)   Arranging kmers in hash map order
   0:00:00.260     1M / 568M  INFO    General                 (main.cpp 
                  : 148)   Clustering Hamming graph.
   0:00:00.262     1M / 568M  INFO    General                 (main.cpp 
                  : 155)   Extracting clusters:
   0:00:00.262     1M / 568M  INFO    General 
(concurrent_dsu.cpp        :  18)   Connecting to root
   0:00:00.262     1M / 568M  INFO    General 
(concurrent_dsu.cpp        :  34)   Calculating counts
   0:00:00.262     1M / 568M  INFO    General 
(concurrent_dsu.cpp        :  63)   Writing down entries
   0:00:00.263     1M / 568M  INFO    General                 (main.cpp 
                  : 167)   Clustering done. Total clusters: 1960
   0:00:00.263     1M / 568M  INFO   K-mer Counting 
(kmer_data.cpp             : 371)   Collecting K-mer information, this 
takes a while.
   0:00:00.263     1M / 568M  INFO   K-mer Counting 
(kmer_data.cpp             : 377)   Processing 
/usr/share/spades/test_dataset/ecoli_1K_1.fq.gz
   0:00:00.273     1M / 568M  INFO   K-mer Counting 
(kmer_data.cpp             : 377)   Processing 
/usr/share/spades/test_dataset/ecoli_1K_2.fq.gz
   0:00:00.281     1M / 568M  INFO   K-mer Counting 
(kmer_data.cpp             : 384)   Collection done, postprocessing.
   0:00:00.282     1M / 568M  INFO   K-mer Counting 
(kmer_data.cpp             : 397)   There are 1974 kmers in total. Among 
them 0 (0%) are singletons.
   0:00:00.282     1M / 568M  INFO    General                 (main.cpp 
                  : 173)   Subclustering Hamming graph
   0:00:00.283     1M / 568M  INFO   Hamming Subclustering 
(kmer_cluster.cpp          : 650)   Subclustering done. Total 0 non-read 
kmers were generated.
   0:00:00.283     1M / 568M  INFO   Hamming Subclustering 
(kmer_cluster.cpp          : 651)   Subclustering statistics:
   0:00:00.283     1M / 568M  INFO   Hamming Subclustering 
(kmer_cluster.cpp          : 652)     Total singleton hamming clusters: 
1946. Among them 1946 (100%) are good
   0:00:00.283     1M / 568M  INFO   Hamming Subclustering 
(kmer_cluster.cpp          : 653)     Total singleton subclusters: 8. 
Among them 8 (100%) are good
   0:00:00.283     1M / 568M  INFO   Hamming Subclustering 
(kmer_cluster.cpp          : 654)     Total non-singleton subcluster 
centers: 10. Among them 10 (100%) are good
   0:00:00.283     1M / 568M  INFO   Hamming Subclustering 
(kmer_cluster.cpp          : 655)     Average size of non-trivial 
subcluster: 2.8 kmers
   0:00:00.283     1M / 568M  INFO   Hamming Subclustering 
(kmer_cluster.cpp          : 656)     Average number of sub-clusters per 
non-singleton cluster: 1.28571
   0:00:00.283     1M / 568M  INFO   Hamming Subclustering 
(kmer_cluster.cpp          : 657)     Total solid k-mers: 1964
   0:00:00.283     1M / 568M  INFO   Hamming Subclustering 
(kmer_cluster.cpp          : 658)     Substitution probabilities: 
[4,4]((0.875,0.125,0,0),(0,1,0,0),(0,0,1,0),(0,0,0.125,0.875))
   0:00:00.283     1M / 568M  INFO    General                 (main.cpp 
                  : 178)   Finished clustering.
   0:00:00.283     1M / 568M  INFO    General                 (main.cpp 
                  : 197)   Starting solid k-mers expansion in 16 threads.
   0:00:00.300     1M / 568M  INFO    General                 (main.cpp 
                  : 218)   Solid k-mers iteration 0 produced 0 new k-mers.
   0:00:00.300     1M / 568M  INFO    General                 (main.cpp 
                  : 222)   Solid k-mers finalized
   0:00:00.300     1M / 568M  INFO    General 
(hammer_tools.cpp          : 222)   Starting read correction in 16 threads.
   0:00:00.300     1M / 568M  INFO    General 
(hammer_tools.cpp          : 235)   Correcting pair of reads: 
/usr/share/spades/test_dataset/ecoli_1K_1.fq.gz and 
/usr/share/spades/test_dataset/ecoli_1K_2.fq.gz
   0:00:00.435   347M / 568M  INFO    General 
(hammer_tools.cpp          : 170)   Prepared batch 0 of 2054 reads.
   0:00:00.438   347M / 568M  INFO    General 
(hammer_tools.cpp          : 177)   Processed batch 0
   0:00:00.442   347M / 568M  INFO    General 
(hammer_tools.cpp          : 187)   Written batch 0
   0:00:00.477     1M / 568M  INFO    General 
(hammer_tools.cpp          : 276)   Correction done. Changed 4 bases in 
4 reads.
   0:00:00.477     1M / 568M  INFO    General 
(hammer_tools.cpp          : 277)   Failed to correct 0 bases out of 353915.
   0:00:00.477     1M / 568M  INFO    General                 (main.cpp 
                  : 255)   Saving corrected dataset description to 
/tmp/tmp.Kw3upbPyKH/spades_test/corrected/corrected.yaml
   0:00:00.477     1M / 568M  INFO    General                 (main.cpp 
                  : 262)   All done. Exiting.

===== Read error correction finished.

===== corrected reads compression started.

== Running: /usr/bin/python3 
/usr/share/spades/spades_pipeline/scripts/compress_all.py --input_file 
/tmp/tmp.Kw3upbPyKH/spades_test/corrected/corrected.yaml 
--ext_python_modules_home /usr/share/spades --max_threads 16 
--output_dir /tmp/tmp.Kw3upbPyKH/spades_test/corrected --gzip_output

== Compressing corrected reads (with gzip)
== Files to compress: 
['/tmp/tmp.Kw3upbPyKH/spades_test/corrected/ecoli_1K_1.fq.00.0_0.cor.fastq', 
'/tmp/tmp.Kw3upbPyKH/spades_test/corrected/ecoli_1K_2.fq.00.0_0.cor.fastq', 
'/tmp/tmp.Kw3upbPyKH/spades_test/corrected/ecoli_1K__unpaired.00.0_0.cor.fastq']
== Files compression is finished
== Dataset yaml file is updated

===== corrected reads compression finished.

===== Read error correction finished.

===== Assembling started.

===== K21 started.

== Running: /usr/libexec/spades/spades-core 
/tmp/tmp.Kw3upbPyKH/spades_test/K21/configs/config.info

   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  :  99)   Loaded config from 
/tmp/tmp.Kw3upbPyKH/spades_test/K21/configs/config.info
   0:00:00.000     1M / 16M   INFO    General 
(memory_limit.cpp          :  54)   Memory limit set to 250 Gb
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 107)   Starting SPAdes, built from N/A, git revision N/A
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 108)   Maximum k-mer length: 128
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 109)   Assembling dataset 
(/tmp/tmp.Kw3upbPyKH/spades_test/dataset.info) with K=21
   0:00:00.001     1M / 16M   INFO    General                 (main.cpp 
                  : 110)   Maximum # of threads to use (adjusted due to 
OMP capabilities): 16
   0:00:00.001     1M / 16M   INFO    General 
(pipeline.cpp              : 212)   SPAdes started
   0:00:00.001     1M / 16M   INFO    General 
(pipeline.cpp              : 225)   Starting from stage: read_conversion
   0:00:00.001     1M / 16M   INFO    General 
(pipeline.cpp              : 231)   Two-step repeat resolution disabled
   0:00:00.001     1M / 16M   INFO   GraphCore 
(graph_core.hpp            : 672)   Graph created, vertex min_id: 3, 
edge min_id: 3
   0:00:00.001     1M / 16M   INFO   GraphCore 
(graph_core.hpp            : 673)   Vertex size: 48, edge size: 40
   0:00:00.001     1M / 16M   INFO    General 
(edge_index.hpp            : 113)   Size of edge index entries: 12/8
   0:00:00.001     1M / 16M   INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Binary Read Conversion (id: 
read_conversion)
   0:00:00.002     1M / 16M   INFO    General 
(read_converter.cpp        :  72)   Converting reads to binary format 
for library #0 (takes a while)
   0:00:00.002     1M / 16M   INFO    General 
(read_converter.cpp        :  73)   Converting paired reads
   0:00:00.025    63M / 63M   INFO    General 
(binary_converter.cpp      : 111)   2054 reads written
   0:00:00.025    41M / 41M   INFO    General 
(read_converter.cpp        :  86)   Converting single reads
   0:00:00.027    71M / 71M   INFO    General 
(binary_converter.cpp      : 111)   0 reads written
   0:00:00.027    61M / 61M   INFO    General 
(read_converter.cpp        :  92)   Converting merged reads
   0:00:00.027    71M / 71M   INFO    General 
(binary_converter.cpp      : 111)   0 reads written
   0:00:00.028     1M / 27M   INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == de Bruijn graph construction (id: 
construction)
   0:00:00.028     1M / 27M   INFO    General 
(construction.cpp          : 153)   Max read length 100
   0:00:00.029     1M / 27M   INFO    General 
(construction.cpp          : 159)   Average read length 86.1526
   0:00:00.029     1M / 27M   INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == k+1-mer counting (id: 
construction:kpomer_counting)
   0:00:00.029     1M / 27M   INFO    General 
(kmer_index_builder.hpp    : 243)   Splitting kmer instances into 160 
files using 16 threads. This might take a while.
   0:00:00.029     1M / 27M   INFO    General 
(file_limit.hpp            :  42)   Open file limit set to 1024
   0:00:00.029     1M / 27M   INFO    General 
(kmer_splitter.hpp         :  93)   Memory available for splitting 
buffers: 5.20832 Gb
   0:00:00.029     1M / 27M   INFO    General 
(kmer_splitter.hpp         : 101)   Using cell size of 419430
   0:00:01.488     1M / 5187M INFO    General 
(kmer_splitters.hpp        : 131)   Used 8216 reads
   0:00:01.503     1M / 5187M INFO    General 
(kmer_index_builder.hpp    : 249)   Starting k-mer counting.
   0:00:01.553     1M / 5187M INFO    General 
(kmer_index_builder.hpp    : 260)   K-mer counting done. There are 984 
kmers in total.
   0:00:01.553     1M / 5187M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Extension index construction (id: 
construction:extension_index_construction)
   0:00:01.555     1M / 5187M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 438)   Building kmer index
   0:00:01.555     1M / 5187M INFO    General 
(kmer_index_builder.hpp    : 243)   Splitting kmer instances into 160 
files using 16 threads. This might take a while.
   0:00:01.555     1M / 5187M INFO    General 
(file_limit.hpp            :  42)   Open file limit set to 1024
   0:00:01.555     1M / 5187M INFO    General 
(kmer_splitter.hpp         :  93)   Memory available for splitting 
buffers: 5.20832 Gb
   0:00:01.555     1M / 5187M INFO    General 
(kmer_splitter.hpp         : 101)   Using cell size of 419430
   0:00:02.928  9601M / 9601M INFO    General 
(kmer_splitters.hpp        : 199)   Used 984 kmers.
   0:00:02.929     1M / 5187M INFO    General 
(kmer_index_builder.hpp    : 249)   Starting k-mer counting.
   0:00:02.951     1M / 5187M INFO    General 
(kmer_index_builder.hpp    : 260)   K-mer counting done. There are 985 
kmers in total.
   0:00:02.951     1M / 5187M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:02.963     2M / 5187M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 985 kmers, 127200 
bytes occupied (1033.1 bits per kmer).
   0:00:02.963     2M / 5187M INFO    General 
(kmer_index_builder.hpp    : 169)   Merging final buckets.
   0:00:02.969     2M / 5187M INFO   DeBruijnExtensionIndexBu 
(kmer_extension_index_build: 100)   Building k-mer extensions from k+1-mers
   0:00:02.971     2M / 5187M INFO   DeBruijnExtensionIndexBu 
(kmer_extension_index_build: 105)   Building k-mer extensions from 
k+1-mers finished.
   0:00:02.973     1M / 5187M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Early tip clipping (id: 
construction:early_tip_clipper)
   0:00:02.973     1M / 5187M INFO    General 
(construction.cpp          : 301)   Early tip clipper length bound set 
as (RL - K)
   0:00:02.973     1M / 5187M INFO   Early tip clipping 
(early_simplification.hpp  :  47)   Early tip clipping
   0:00:02.974     1M / 5187M INFO   Early tip clipping 
(early_simplification.hpp  :  82)   #tipped junctions: 2
   0:00:02.974     1M / 5187M INFO   Early tip clipping 
(early_simplification.hpp  :  93)   Clipped tips: 2
   0:00:02.974     1M / 5187M INFO   Early tip clipping 
(early_simplification.hpp  :  49)   5 22-mers were removed by early tip 
clipper
   0:00:02.974     1M / 5187M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Condensing graph (id: 
construction:graph_condensing)
   0:00:02.974     1M / 5187M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 354)   Extracting unbranching paths
   0:00:02.974     1M / 5187M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 373)   Extracting unbranching paths 
finished. 1 sequences extracted
   0:00:02.974     1M / 5187M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 309)   Collecting perfect loops
   0:00:02.974     1M / 5187M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 342)   Collecting perfect loops finished. 0 
loops collected
   0:00:02.974     1M / 5187M INFO    General 
(debruijn_graph_constructor: 487)   Total 2 edges to create
   0:00:02.974     1M / 5187M INFO    General 
(debruijn_graph_constructor: 489)   Collecting link records
   0:00:02.975     1M / 5187M INFO    General 
(debruijn_graph_constructor: 491)   Ordering link records
   0:00:02.975     1M / 5187M INFO    General 
(debruijn_graph_constructor: 493)   Sorting done
   0:00:02.975     1M / 5187M INFO    General 
(debruijn_graph_constructor: 503)   Total 2 vertices to create
   0:00:02.975     1M / 5187M INFO    General 
(debruijn_graph_constructor: 506)   Connecting the graph
   0:00:02.975     1M / 5187M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Filling coverage indices (PHM) 
(id: construction:coverage_filling_phm)
   0:00:02.975     2M / 5187M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:02.987     2M / 5187M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 984 kmers, 128008 
bytes occupied (1040.72 bits per kmer).
   0:00:02.987     2M / 5187M INFO    General 
(coverage_hash_map_builder.:  47)   Collecting k-mer coverage 
information from reads, this takes a while.
   0:00:02.994     2M / 5187M INFO    General 
(construction.cpp          : 430)   Filling coverage and flanking 
coverage from PHM
   0:00:02.998     1M / 5187M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == EC Threshold Finding (id: 
ec_threshold_finder)
   0:00:02.999     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 181)   Kmer coverage valley at: 0
   0:00:02.999     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 201)   K-mer histogram maximum: 348
   0:00:02.999     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 237)   Estimated median coverage: 348. 
Coverage mad: 62.2692
   0:00:02.999     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 259)   Fitting coverage model
   0:00:03.048     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 2
   0:00:03.147     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 4
   0:00:03.346     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 8
   0:00:03.639     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 16
   0:00:04.157     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 32
   0:00:05.406     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 309)   Fitted mean coverage: 342.845. 
Fitted coverage std. dev: 68.3997
   0:00:05.407     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 334)   Probability of erroneous kmer at 
valley: 0.999994
   0:00:05.407     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 358)   Preliminary threshold calculated as: 355
   0:00:05.407     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 362)   Threshold adjusted to: 171
   0:00:05.407     1M / 5187M INFO    General 
(kmer_coverage_model.cpp   : 375)   Estimated genome size (ignoring 
repeats): 749
   0:00:05.407     1M / 5187M INFO    General 
(genomic_info_filler.cpp   :  55)   Mean coverage was calculated as 342.845
   0:00:05.407     1M / 5187M INFO    General 
(genomic_info_filler.cpp   :  70)   EC coverage threshold value was 
calculated as 171
   0:00:05.407     1M / 5187M INFO    General 
(genomic_info_filler.cpp   :  71)   Trusted kmer low bound: 0
   0:00:05.407     1M / 5187M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Raw Simplification (id: 
raw_simplification)
   0:00:05.407     1M / 5187M INFO    General 
(simplification.cpp        : 127)   PROCEDURE == Initial cleaning
   0:00:05.407     1M / 5187M INFO    General 
(graph_simplification.hpp  : 662)   Flanking coverage based 
disconnection disabled
   0:00:05.407     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Self conjugate edge remover
   0:00:05.407     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Self conjugate edge remover 
triggered 0 times
   0:00:05.407     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Initial tip clipper
   0:00:05.407     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Initial tip clipper triggered 0 times
   0:00:05.407     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Initial ec remover
   0:00:05.407     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Initial ec remover triggered 0 times
   0:00:05.407     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Initial isolated edge remover
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Initial isolated edge remover 
triggered 0 times
   0:00:05.408     1M / 5187M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Simplification (id: simplification)
   0:00:05.408     1M / 5187M INFO    General 
(simplification.cpp        : 368)   Graph simplification started
   0:00:05.408     1M / 5187M INFO    General 
(graph_simplification.hpp  : 634)   Creating parallel br instance
   0:00:05.408     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 1
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.408     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 2
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.408     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 3
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.408     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 4
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.408     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 5
   0:00:05.408     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.409     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 6
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.409     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 7
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.409     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 8
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.409     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 9
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.409     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 10
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.409     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.410     1M / 5187M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 11
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.410     1M / 5187M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Simplification Cleanup (id: 
simplification_cleanup)
   0:00:05.410     1M / 5187M INFO    General 
(simplification.cpp        : 176)   PROCEDURE == Post simplification
   0:00:05.410     1M / 5187M INFO    General 
(graph_simplification.hpp  : 448)   Disconnection of relatively low 
covered edges disabled
   0:00:05.410     1M / 5187M INFO    General 
(graph_simplification.hpp  : 485)   Complex tip clipping disabled
   0:00:05.410     1M / 5187M INFO    General 
(graph_simplification.hpp  : 634)   Creating parallel br instance
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.410     1M / 5187M INFO    General 
(simplification.cpp        : 327)   Disrupting self-conjugate edges
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Removing isolated edges
   0:00:05.410     1M / 5187M INFO   Simplification 
(parallel_processing.hpp   : 170)   Removing isolated edges triggered 0 
times
   0:00:05.410     1M / 5187M INFO    General 
(simplification.cpp        : 495)   After simplification:
   0:00:05.410     1M / 5187M INFO    General 
(simplification.cpp        : 496)     Average coverage = 273.35
   0:00:05.410     1M / 5187M INFO    General 
(simplification.cpp        : 497)     Total length = 979
   0:00:05.410     1M / 5187M INFO    General 
(simplification.cpp        : 498)     Median edge length: 979
   0:00:05.410     1M / 5187M INFO    General 
(simplification.cpp        : 499)     Edges: 2
   0:00:05.410     1M / 5187M INFO    General 
(simplification.cpp        : 500)     Vertices: 4
   0:00:05.410     1M / 5187M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Contig Output (id: contig_output)
   0:00:05.411     1M / 5187M INFO    General 
(read_converter.cpp        : 107)   Outputting contigs to 
/tmp/tmp.Kw3upbPyKH/spades_test/K21/simplified_contigs
   0:00:05.411     3M / 5187M INFO    General 
(binary_converter.cpp      : 111)   1 reads written
   0:00:05.413     1M / 5187M INFO    General 
(pipeline.cpp              : 287)   SPAdes finished
   0:00:05.413     1M / 5187M INFO    General                 (main.cpp 
                  : 136)   Assembling time: 0 hours 0 minutes 5 seconds

===== K21 finished.

===== K33 started.

== Running: /usr/libexec/spades/spades-core 
/tmp/tmp.Kw3upbPyKH/spades_test/K33/configs/config.info

   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  :  99)   Loaded config from 
/tmp/tmp.Kw3upbPyKH/spades_test/K33/configs/config.info
   0:00:00.000     1M / 16M   INFO    General 
(memory_limit.cpp          :  54)   Memory limit set to 250 Gb
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 107)   Starting SPAdes, built from N/A, git revision N/A
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 108)   Maximum k-mer length: 128
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 109)   Assembling dataset 
(/tmp/tmp.Kw3upbPyKH/spades_test/dataset.info) with K=33
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 110)   Maximum # of threads to use (adjusted due to 
OMP capabilities): 16
   0:00:00.000     1M / 16M   INFO    General 
(pipeline.cpp              : 212)   SPAdes started
   0:00:00.000     1M / 16M   INFO    General 
(pipeline.cpp              : 225)   Starting from stage: read_conversion
   0:00:00.000     1M / 16M   INFO    General 
(pipeline.cpp              : 231)   Two-step repeat resolution disabled
   0:00:00.000     1M / 16M   INFO   GraphCore 
(graph_core.hpp            : 672)   Graph created, vertex min_id: 3, 
edge min_id: 3
   0:00:00.000     1M / 16M   INFO   GraphCore 
(graph_core.hpp            : 673)   Vertex size: 48, edge size: 40
   0:00:00.000     1M / 16M   INFO    General 
(edge_index.hpp            : 113)   Size of edge index entries: 12/8
   0:00:00.001     1M / 16M   INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Binary Read Conversion (id: 
read_conversion)
   0:00:00.001     1M / 16M   INFO    General 
(read_converter.cpp        :  53)   Binary reads detected
   0:00:00.002     1M / 16M   INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == de Bruijn graph construction (id: 
construction)
   0:00:00.002     1M / 16M   INFO    General 
(construction.cpp          : 118)   Contigs from previous K will be 
used: /tmp/tmp.Kw3upbPyKH/spades_test/K21/simplified_contigs
   0:00:00.046     1M / 16M   INFO    General 
(construction.cpp          : 153)   Max read length 100
   0:00:00.047     1M / 16M   INFO    General 
(construction.cpp          : 159)   Average read length 86.1526
   0:00:00.047     1M / 16M   INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == k+1-mer counting (id: 
construction:kpomer_counting)
   0:00:00.047     1M / 16M   INFO    General 
(kmer_index_builder.hpp    : 243)   Splitting kmer instances into 160 
files using 16 threads. This might take a while.
   0:00:00.047     1M / 16M   INFO    General 
(file_limit.hpp            :  42)   Open file limit set to 1024
   0:00:00.047     1M / 16M   INFO    General 
(kmer_splitter.hpp         :  93)   Memory available for splitting 
buffers: 5.20832 Gb
   0:00:00.047     1M / 16M   INFO    General 
(kmer_splitter.hpp         : 101)   Using cell size of 209715
   0:00:01.540     1M / 5192M INFO    General 
(kmer_splitters.hpp        : 131)   Used 8218 reads
   0:00:01.554     1M / 5192M INFO    General 
(kmer_index_builder.hpp    : 249)   Starting k-mer counting.
   0:00:01.562     1M / 5192M INFO    General 
(kmer_index_builder.hpp    : 260)   K-mer counting done. There are 972 
kmers in total.
   0:00:01.562     1M / 5192M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Extension index construction (id: 
construction:extension_index_construction)
   0:00:01.564     1M / 5192M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 438)   Building kmer index
   0:00:01.564     1M / 5192M INFO    General 
(kmer_index_builder.hpp    : 243)   Splitting kmer instances into 160 
files using 16 threads. This might take a while.
   0:00:01.564     1M / 5192M INFO    General 
(file_limit.hpp            :  42)   Open file limit set to 1024
   0:00:01.564     1M / 5192M INFO    General 
(kmer_splitter.hpp         :  93)   Memory available for splitting 
buffers: 5.20832 Gb
   0:00:01.564     1M / 5192M INFO    General 
(kmer_splitter.hpp         : 101)   Using cell size of 209715
   0:00:02.935  9602M / 9602M INFO    General 
(kmer_splitters.hpp        : 199)   Used 972 kmers.
   0:00:03.088     2M / 5192M INFO    General 
(kmer_index_builder.hpp    : 249)   Starting k-mer counting.
   0:00:03.110     2M / 5192M INFO    General 
(kmer_index_builder.hpp    : 260)   K-mer counting done. There are 973 
kmers in total.
   0:00:03.110     2M / 5192M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:03.122     2M / 5192M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 973 kmers, 128000 
bytes occupied (1052.42 bits per kmer).
   0:00:03.122     2M / 5192M INFO    General 
(kmer_index_builder.hpp    : 169)   Merging final buckets.
   0:00:03.128     2M / 5192M INFO   DeBruijnExtensionIndexBu 
(kmer_extension_index_build: 100)   Building k-mer extensions from k+1-mers
   0:00:03.131     2M / 5192M INFO   DeBruijnExtensionIndexBu 
(kmer_extension_index_build: 105)   Building k-mer extensions from 
k+1-mers finished.
   0:00:03.133     2M / 5192M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Early tip clipping (id: 
construction:early_tip_clipper)
   0:00:03.133     2M / 5192M INFO    General 
(construction.cpp          : 301)   Early tip clipper length bound set 
as (RL - K)
   0:00:03.133     2M / 5192M INFO   Early tip clipping 
(early_simplification.hpp  :  47)   Early tip clipping
   0:00:03.133     2M / 5192M INFO   Early tip clipping 
(early_simplification.hpp  :  82)   #tipped junctions: 2
   0:00:03.133     2M / 5192M INFO   Early tip clipping 
(early_simplification.hpp  :  93)   Clipped tips: 2
   0:00:03.133     2M / 5192M INFO   Early tip clipping 
(early_simplification.hpp  :  49)   5 34-mers were removed by early tip 
clipper
   0:00:03.133     2M / 5192M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Condensing graph (id: 
construction:graph_condensing)
   0:00:03.133     2M / 5192M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 354)   Extracting unbranching paths
   0:00:03.134     2M / 5192M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 373)   Extracting unbranching paths 
finished. 1 sequences extracted
   0:00:03.134     2M / 5192M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 309)   Collecting perfect loops
   0:00:03.134     2M / 5192M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 342)   Collecting perfect loops finished. 0 
loops collected
   0:00:03.134     2M / 5192M INFO    General 
(debruijn_graph_constructor: 487)   Total 2 edges to create
   0:00:03.135     2M / 5192M INFO    General 
(debruijn_graph_constructor: 489)   Collecting link records
   0:00:03.135     2M / 5192M INFO    General 
(debruijn_graph_constructor: 491)   Ordering link records
   0:00:03.135     2M / 5192M INFO    General 
(debruijn_graph_constructor: 493)   Sorting done
   0:00:03.135     2M / 5192M INFO    General 
(debruijn_graph_constructor: 503)   Total 2 vertices to create
   0:00:03.136     2M / 5192M INFO    General 
(debruijn_graph_constructor: 506)   Connecting the graph
   0:00:03.136     2M / 5192M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Filling coverage indices (PHM) 
(id: construction:coverage_filling_phm)
   0:00:03.136     2M / 5192M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:03.148     2M / 5192M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 972 kmers, 126400 
bytes occupied (1040.33 bits per kmer).
   0:00:03.148     2M / 5192M INFO    General 
(coverage_hash_map_builder.:  47)   Collecting k-mer coverage 
information from reads, this takes a while.
   0:00:03.154     2M / 5192M INFO    General 
(construction.cpp          : 430)   Filling coverage and flanking 
coverage from PHM
   0:00:03.158     1M / 5192M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == EC Threshold Finding (id: 
ec_threshold_finder)
   0:00:03.158     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 181)   Kmer coverage valley at: 0
   0:00:03.160     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 201)   K-mer histogram maximum: 17
   0:00:03.160     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 237)   Estimated median coverage: 17. 
Coverage mad: 11.8608
   0:00:03.160     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 259)   Fitting coverage model
   0:00:03.180     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 2
   0:00:03.228     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 4
   0:00:03.299     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 8
   0:00:03.398     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 16
   0:00:03.574     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 32
   0:00:03.906     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 64
   0:00:04.505     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 128
   0:00:05.326     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 309)   Fitted mean coverage: 108.181. 
Fitted coverage std. dev: 65.0594
   0:00:05.327     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 334)   Probability of erroneous kmer at 
valley: 0.0555142
   0:00:05.327     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 358)   Preliminary threshold calculated as: 3
   0:00:05.327     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 362)   Threshold adjusted to: 3
   0:00:05.327     1M / 5192M INFO    General 
(kmer_coverage_model.cpp   : 375)   Estimated genome size (ignoring 
repeats): 400
   0:00:05.327     1M / 5192M INFO    General 
(genomic_info_filler.cpp   :  55)   Mean coverage was calculated as 108.181
   0:00:05.327     1M / 5192M INFO    General 
(genomic_info_filler.cpp   :  70)   EC coverage threshold value was 
calculated as 3
   0:00:05.327     1M / 5192M INFO    General 
(genomic_info_filler.cpp   :  71)   Trusted kmer low bound: 0
   0:00:05.327     1M / 5192M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Raw Simplification (id: 
raw_simplification)
   0:00:05.327     1M / 5192M INFO    General 
(simplification.cpp        : 127)   PROCEDURE == Initial cleaning
   0:00:05.327     1M / 5192M INFO    General 
(graph_simplification.hpp  : 662)   Flanking coverage based 
disconnection disabled
   0:00:05.327     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Self conjugate edge remover
   0:00:05.327     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Self conjugate edge remover 
triggered 0 times
   0:00:05.327     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Initial tip clipper
   0:00:05.327     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Initial tip clipper triggered 0 times
   0:00:05.327     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Initial ec remover
   0:00:05.327     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Initial ec remover triggered 0 times
   0:00:05.327     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Initial isolated edge remover
   0:00:05.327     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Initial isolated edge remover 
triggered 0 times
   0:00:05.327     1M / 5192M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Simplification (id: simplification)
   0:00:05.327     1M / 5192M INFO    General 
(simplification.cpp        : 368)   Graph simplification started
   0:00:05.328     1M / 5192M INFO    General 
(graph_simplification.hpp  : 634)   Creating parallel br instance
   0:00:05.328     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 1
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.328     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 2
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.328     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 3
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.328     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 4
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.328     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 5
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.328     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 6
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.328     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.329     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 7
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.329     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 8
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.329     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 9
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.329     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 10
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.329     1M / 5192M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 11
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:05.329     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:05.329     1M / 5192M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Simplification Cleanup (id: 
simplification_cleanup)
   0:00:05.330     1M / 5192M INFO    General 
(simplification.cpp        : 176)   PROCEDURE == Post simplification
   0:00:05.330     1M / 5192M INFO    General 
(graph_simplification.hpp  : 448)   Disconnection of relatively low 
covered edges disabled
   0:00:05.330     1M / 5192M INFO    General 
(graph_simplification.hpp  : 485)   Complex tip clipping disabled
   0:00:05.330     1M / 5192M INFO    General 
(graph_simplification.hpp  : 634)   Creating parallel br instance
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:05.330     1M / 5192M INFO    General 
(simplification.cpp        : 327)   Disrupting self-conjugate edges
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Removing isolated edges
   0:00:05.330     1M / 5192M INFO   Simplification 
(parallel_processing.hpp   : 170)   Removing isolated edges triggered 0 
times
   0:00:05.330     1M / 5192M INFO    General 
(simplification.cpp        : 495)   After simplification:
   0:00:05.330     1M / 5192M INFO    General 
(simplification.cpp        : 496)     Average coverage = 225.839
   0:00:05.330     1M / 5192M INFO    General 
(simplification.cpp        : 497)     Total length = 967
   0:00:05.330     1M / 5192M INFO    General 
(simplification.cpp        : 498)     Median edge length: 967
   0:00:05.330     1M / 5192M INFO    General 
(simplification.cpp        : 499)     Edges: 2
   0:00:05.330     1M / 5192M INFO    General 
(simplification.cpp        : 500)     Vertices: 4
   0:00:05.330     1M / 5192M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Contig Output (id: contig_output)
   0:00:05.330     1M / 5192M INFO    General 
(read_converter.cpp        : 107)   Outputting contigs to 
/tmp/tmp.Kw3upbPyKH/spades_test/K33/simplified_contigs
   0:00:05.331     3M / 5192M INFO    General 
(binary_converter.cpp      : 111)   1 reads written
   0:00:05.332     1M / 5192M INFO    General 
(pipeline.cpp              : 287)   SPAdes finished
   0:00:05.332     1M / 5192M INFO    General                 (main.cpp 
                  : 136)   Assembling time: 0 hours 0 minutes 5 seconds

===== K33 finished.

===== K55 started.

== Running: /usr/libexec/spades/spades-core 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/configs/config.info

   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  :  99)   Loaded config from 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/configs/config.info
   0:00:00.000     1M / 16M   INFO    General 
(memory_limit.cpp          :  54)   Memory limit set to 250 Gb
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 107)   Starting SPAdes, built from N/A, git revision N/A
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 108)   Maximum k-mer length: 128
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 109)   Assembling dataset 
(/tmp/tmp.Kw3upbPyKH/spades_test/dataset.info) with K=55
   0:00:00.000     1M / 16M   INFO    General                 (main.cpp 
                  : 110)   Maximum # of threads to use (adjusted due to 
OMP capabilities): 16
   0:00:00.000     1M / 16M   INFO    General 
(pipeline.cpp              : 212)   SPAdes started
   0:00:00.000     1M / 16M   INFO    General 
(pipeline.cpp              : 225)   Starting from stage: read_conversion
   0:00:00.000     1M / 16M   INFO    General 
(pipeline.cpp              : 231)   Two-step repeat resolution disabled
   0:00:00.000     1M / 16M   INFO   GraphCore 
(graph_core.hpp            : 672)   Graph created, vertex min_id: 3, 
edge min_id: 3
   0:00:00.000     1M / 16M   INFO   GraphCore 
(graph_core.hpp            : 673)   Vertex size: 48, edge size: 40
   0:00:00.000     1M / 16M   INFO    General 
(edge_index.hpp            : 113)   Size of edge index entries: 12/8
   0:00:00.000     1M / 16M   INFO    General 
(pipeline.cpp              : 242)   Will need read mapping, kmer mapper 
will be attached
   0:00:00.001     1M / 16M   INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Binary Read Conversion (id: 
read_conversion)
   0:00:00.001     1M / 16M   INFO    General 
(read_converter.cpp        :  53)   Binary reads detected
   0:00:00.002     1M / 16M   INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == de Bruijn graph construction (id: 
construction)
   0:00:00.002     1M / 16M   INFO    General 
(construction.cpp          : 118)   Contigs from previous K will be 
used: /tmp/tmp.Kw3upbPyKH/spades_test/K33/simplified_contigs
   0:00:00.045     1M / 16M   INFO    General 
(construction.cpp          : 153)   Max read length 100
   0:00:00.045     1M / 16M   INFO    General 
(construction.cpp          : 159)   Average read length 86.1526
   0:00:00.045     1M / 16M   INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == k+1-mer counting (id: 
construction:kpomer_counting)
   0:00:00.045     1M / 16M   INFO    General 
(kmer_index_builder.hpp    : 243)   Splitting kmer instances into 160 
files using 16 threads. This might take a while.
   0:00:00.045     1M / 16M   INFO    General 
(file_limit.hpp            :  42)   Open file limit set to 1024
   0:00:00.045     1M / 16M   INFO    General 
(kmer_splitter.hpp         :  93)   Memory available for splitting 
buffers: 5.20832 Gb
   0:00:00.045     1M / 16M   INFO    General 
(kmer_splitter.hpp         : 101)   Using cell size of 209715
   0:00:01.488     1M / 5186M INFO    General 
(kmer_splitters.hpp        : 131)   Used 8218 reads
   0:00:01.503     1M / 5186M INFO    General 
(kmer_index_builder.hpp    : 249)   Starting k-mer counting.
   0:00:01.514     1M / 5186M INFO    General 
(kmer_index_builder.hpp    : 260)   K-mer counting done. There are 949 
kmers in total.
   0:00:01.514     1M / 5186M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Extension index construction (id: 
construction:extension_index_construction)
   0:00:01.516     1M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 438)   Building kmer index
   0:00:01.516     1M / 5186M INFO    General 
(kmer_index_builder.hpp    : 243)   Splitting kmer instances into 160 
files using 16 threads. This might take a while.
   0:00:01.516     1M / 5186M INFO    General 
(file_limit.hpp            :  42)   Open file limit set to 1024
   0:00:01.516     1M / 5186M INFO    General 
(kmer_splitter.hpp         :  93)   Memory available for splitting 
buffers: 5.20832 Gb
   0:00:01.516     1M / 5186M INFO    General 
(kmer_splitter.hpp         : 101)   Using cell size of 209715
   0:00:02.862  9602M / 9602M INFO    General 
(kmer_splitters.hpp        : 199)   Used 949 kmers.
   0:00:02.863     2M / 5186M INFO    General 
(kmer_index_builder.hpp    : 249)   Starting k-mer counting.
   0:00:02.888     2M / 5186M INFO    General 
(kmer_index_builder.hpp    : 260)   K-mer counting done. There are 951 
kmers in total.
   0:00:02.888     2M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:02.901     2M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 951 kmers, 126400 
bytes occupied (1063.3 bits per kmer).
   0:00:02.902     2M / 5186M INFO    General 
(kmer_index_builder.hpp    : 169)   Merging final buckets.
   0:00:02.908     2M / 5186M INFO   DeBruijnExtensionIndexBu 
(kmer_extension_index_build: 100)   Building k-mer extensions from k+1-mers
   0:00:02.910     2M / 5186M INFO   DeBruijnExtensionIndexBu 
(kmer_extension_index_build: 105)   Building k-mer extensions from 
k+1-mers finished.
   0:00:02.912     2M / 5186M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Condensing graph (id: 
construction:graph_condensing)
   0:00:02.913     2M / 5186M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 354)   Extracting unbranching paths
   0:00:02.913     2M / 5186M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 373)   Extracting unbranching paths 
finished. 4 sequences extracted
   0:00:02.913     2M / 5186M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 309)   Collecting perfect loops
   0:00:02.913     2M / 5186M INFO   UnbranchingPathExtractor 
(debruijn_graph_constructor: 342)   Collecting perfect loops finished. 0 
loops collected
   0:00:02.913     2M / 5186M INFO    General 
(debruijn_graph_constructor: 487)   Total 8 edges to create
   0:00:02.913     2M / 5186M INFO    General 
(debruijn_graph_constructor: 489)   Collecting link records
   0:00:02.913     2M / 5186M INFO    General 
(debruijn_graph_constructor: 491)   Ordering link records
   0:00:02.913     2M / 5186M INFO    General 
(debruijn_graph_constructor: 493)   Sorting done
   0:00:02.913     2M / 5186M INFO    General 
(debruijn_graph_constructor: 503)   Total 6 vertices to create
   0:00:02.913     2M / 5186M INFO    General 
(debruijn_graph_constructor: 506)   Connecting the graph
   0:00:02.913     2M / 5186M INFO    General                 (stage.cpp 
                 : 117)   PROCEDURE == Filling coverage indices (PHM) 
(id: construction:coverage_filling_phm)
   0:00:02.914     2M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:02.925     2M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 949 kmers, 128000 
bytes occupied (1079.03 bits per kmer).
   0:00:02.925     2M / 5186M INFO    General 
(coverage_hash_map_builder.:  47)   Collecting k-mer coverage 
information from reads, this takes a while.
   0:00:02.929     2M / 5186M INFO    General 
(construction.cpp          : 430)   Filling coverage and flanking 
coverage from PHM
   0:00:02.933     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == EC Threshold Finding (id: 
ec_threshold_finder)
   0:00:02.933     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 181)   Kmer coverage valley at: 0
   0:00:02.934     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 201)   K-mer histogram maximum: 6
   0:00:02.934     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 237)   Estimated median coverage: 6. 
Coverage mad: 4.4478
   0:00:02.934     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 259)   Fitting coverage model
   0:00:02.939     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 2
   0:00:02.959     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 4
   0:00:03.016     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 8
   0:00:03.098     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 295)   ... iteration 16
   0:00:03.171     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 309)   Fitted mean coverage: 13.7375. 
Fitted coverage std. dev: 9.60863
   0:00:03.171     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 334)   Probability of erroneous kmer at 
valley: 2.02732e-07
   0:00:03.171     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 358)   Preliminary threshold calculated as: 1
   0:00:03.171     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 362)   Threshold adjusted to: 1
   0:00:03.171     1M / 5186M INFO    General 
(kmer_coverage_model.cpp   : 375)   Estimated genome size (ignoring 
repeats): 238
   0:00:03.171     1M / 5186M INFO    General 
(genomic_info_filler.cpp   :  55)   Mean coverage was calculated as 13.7375
   0:00:03.171     1M / 5186M INFO    General 
(genomic_info_filler.cpp   :  70)   EC coverage threshold value was 
calculated as 1
   0:00:03.171     1M / 5186M INFO    General 
(genomic_info_filler.cpp   :  71)   Trusted kmer low bound: 0
   0:00:03.171     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Gap Closer (id: early_gapcloser)
   0:00:03.177    10M / 5186M INFO    General 
(edge_index.hpp            : 113)   Size of edge index entries: 12/8
   0:00:03.177    10M / 5186M INFO    General 
(gap_closer.cpp            : 101)   Total edges in tip neighborhood: 7 
out of 8, length: 1520
   0:00:03.177    10M / 5186M INFO    General 
(edge_index.hpp            : 167)   Using small index (max_id = 11)
   0:00:03.178    10M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:03.179    10M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 949 kmers, 1456 
bytes occupied (12.274 bits per kmer).
   0:00:03.179    10M / 5186M INFO    General 
(edge_index_builders.hpp   : 265)   Collecting edge information from 
graph, this takes a while.
   0:00:03.181    10M / 5186M INFO    General 
(sequence_mapper_notifier.h:  95)   Total 2054 reads processed
   0:00:03.184    10M / 5186M INFO    General 
(gap_closer.cpp            : 452)   Initializing gap closer
   0:00:03.184    10M / 5186M INFO   GapCloser 
(gap_closer.cpp            : 359)   Closing short gaps
   0:00:03.185    10M / 5186M INFO   GapCloser 
(gap_closer.cpp            : 391)   Closing short gaps complete: filled 
0 gaps after checking 4 candidates
   0:00:03.185    10M / 5186M INFO    General 
(gap_closer.cpp            : 456)   Gap closer done
   0:00:03.185     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Raw Simplification (id: 
raw_simplification)
   0:00:03.186     1M / 5186M INFO    General 
(simplification.cpp        : 127)   PROCEDURE == Initial cleaning
   0:00:03.186     1M / 5186M INFO    General 
(graph_simplification.hpp  : 662)   Flanking coverage based 
disconnection disabled
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Self conjugate edge remover
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Self conjugate edge remover 
triggered 0 times
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Initial tip clipper
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Initial tip clipper triggered 0 times
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Initial ec remover
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Initial ec remover triggered 0 times
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Initial isolated edge remover
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Initial isolated edge remover 
triggered 1 times
   0:00:03.186     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Simplification (id: simplification)
   0:00:03.186     1M / 5186M INFO    General 
(simplification.cpp        : 368)   Graph simplification started
   0:00:03.186     1M / 5186M INFO    General 
(graph_simplification.hpp  : 634)   Creating parallel br instance
   0:00:03.186     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 1
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 1 times
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.186     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.187     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 2
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.187     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 3
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.187     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 4
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.187     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 5
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.187     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 6
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.187     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 7
   0:00:03.187     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.188     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 8
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.188     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 9
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.188     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 10
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.188     1M / 5186M INFO    General 
(simplification.cpp        : 373)   PROCEDURE == Simplification cycle, 
iteration 11
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Low coverage edge remover
   0:00:03.188     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Low coverage edge remover triggered 
0 times
   0:00:03.188     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Gap Closer (id: late_gapcloser)
   0:00:03.194    10M / 5186M INFO    General 
(edge_index.hpp            : 113)   Size of edge index entries: 12/8
   0:00:03.194    10M / 5186M INFO    General 
(gap_closer.cpp            : 101)   Total edges in tip neighborhood: 2 
out of 2, length: 1890
   0:00:03.194    10M / 5186M INFO    General 
(edge_index.hpp            : 167)   Using small index (max_id = 11)
   0:00:03.194    10M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:03.195    10M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 945 kmers, 1456 
bytes occupied (12.3259 bits per kmer).
   0:00:03.195    10M / 5186M INFO    General 
(edge_index_builders.hpp   : 265)   Collecting edge information from 
graph, this takes a while.
   0:00:03.198    10M / 5186M INFO    General 
(sequence_mapper_notifier.h:  95)   Total 2054 reads processed
   0:00:03.201    10M / 5186M INFO    General 
(gap_closer.cpp            : 452)   Initializing gap closer
   0:00:03.201    10M / 5186M INFO   GapCloser 
(gap_closer.cpp            : 359)   Closing short gaps
   0:00:03.201    10M / 5186M INFO   GapCloser 
(gap_closer.cpp            : 391)   Closing short gaps complete: filled 
0 gaps after checking 0 candidates
   0:00:03.201    10M / 5186M INFO    General 
(gap_closer.cpp            : 456)   Gap closer done
   0:00:03.202     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Simplification Cleanup (id: 
simplification_cleanup)
   0:00:03.202     1M / 5186M INFO    General 
(simplification.cpp        : 176)   PROCEDURE == Post simplification
   0:00:03.202     1M / 5186M INFO    General 
(graph_simplification.hpp  : 448)   Disconnection of relatively low 
covered edges disabled
   0:00:03.202     1M / 5186M INFO    General 
(graph_simplification.hpp  : 485)   Complex tip clipping disabled
   0:00:03.202     1M / 5186M INFO    General 
(graph_simplification.hpp  : 634)   Creating parallel br instance
   0:00:03.202     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.202     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.202     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.202     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.202     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Tip clipper
   0:00:03.202     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Tip clipper triggered 0 times
   0:00:03.202     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Bulge remover
   0:00:03.203     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Bulge remover triggered 0 times
   0:00:03.203     1M / 5186M INFO    General 
(simplification.cpp        : 327)   Disrupting self-conjugate edges
   0:00:03.203     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 167)   Running Removing isolated edges
   0:00:03.203     1M / 5186M INFO   Simplification 
(parallel_processing.hpp   : 170)   Removing isolated edges triggered 0 
times
   0:00:03.203     1M / 5186M INFO    General 
(simplification.cpp        : 495)   After simplification:
   0:00:03.203     1M / 5186M INFO    General 
(simplification.cpp        : 496)     Average coverage = 140.62
   0:00:03.203     1M / 5186M INFO    General 
(simplification.cpp        : 497)     Total length = 945
   0:00:03.203     1M / 5186M INFO    General 
(simplification.cpp        : 498)     Median edge length: 945
   0:00:03.203     1M / 5186M INFO    General 
(simplification.cpp        : 499)     Edges: 2
   0:00:03.203     1M / 5186M INFO    General 
(simplification.cpp        : 500)     Vertices: 4
   0:00:03.203     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Mismatch Correction (id: 
mismatch_correction)
   0:00:03.203     1M / 5186M INFO    General 
(graph_pack.cpp            :  67)   Index refill
   0:00:03.203     1M / 5186M INFO    General 
(edge_index.hpp            : 156)   Using small index (max_id = 11)
   0:00:03.203     1M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 395)   Building perfect hash indices
   0:00:03.203     1M / 5186M INFO   K-mer Index Building 
(kmer_index_builder.hpp    : 431)   Index built. Total 945 kmers, 1456 
bytes occupied (12.3259 bits per kmer).
   0:00:03.203     1M / 5186M INFO    General 
(edge_index_builders.hpp   : 252)   Collecting edge information from 
graph, this takes a while.
   0:00:03.203     1M / 5186M INFO    General 
(graph_pack.cpp            :  77)   Normalizing k-mer map. Total 0 kmers 
to process
   0:00:03.204     1M / 5186M INFO    General 
(graph_pack.cpp            :  79)   Normalizing done
   0:00:03.204     1M / 5186M INFO    General 
(mismatch_correction.cpp   : 400)   Collect potential mismatches
   0:00:03.204     1M / 5186M INFO    General 
(mismatch_correction.cpp   : 192)   Total 0 edges (out of 2) with 0 
potential mismatch positions (-nan positions per edge)
   0:00:03.204     1M / 5186M INFO    General 
(mismatch_correction.cpp   : 402)   Potential mismatches collected
   0:00:03.207     1M / 5186M INFO    General 
(sequence_mapper_notifier.h:  95)   Total 8216 reads processed
   0:00:03.207     1M / 5186M INFO    General 
(mismatch_correction.cpp   : 395)   All edges processed
   0:00:03.207     1M / 5186M INFO    General 
(mismatch_correction.cpp   : 450)   Corrected 0 nucleotides
   0:00:03.207     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Contig Output (id: contig_output)
   0:00:03.207     1M / 5186M INFO    General 
(contig_output.hpp         :  16)   Outputting contigs to 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/before_rr.fasta
   0:00:03.207     1M / 5186M INFO    General 
(contig_output_stage.cpp   : 151)   Writing GFA graph to 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/assembly_graph_after_simplification.gfa
   0:00:03.207     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Paired Information Counting (id: 
late_pair_info_count)
   0:00:03.207     1M / 5186M INFO    General 
(graph_pack.cpp            :  77)   Normalizing k-mer map. Total 0 kmers 
to process
   0:00:03.207     1M / 5186M INFO    General 
(graph_pack.cpp            :  79)   Normalizing done
   0:00:03.207     1M / 5186M INFO    General 
(pair_info_count.cpp       : 339)   Min edge length for estimation: 945
   0:00:03.207     1M / 5186M INFO    General 
(pair_info_count.cpp       : 350)   Estimating insert size for library #0
   0:00:03.207     1M / 5186M INFO    General 
(pair_info_count.cpp       : 202)   Estimating insert size (takes a while)
   0:00:03.307   273M / 5186M INFO    General 
(pair_info_count.cpp       :  48)   Selecting usual mapper
   0:00:04.305   273M / 5186M INFO    General 
(sequence_mapper_notifier.h:  95)   Total 2054 reads processed
   0:00:04.523   273M / 5186M INFO    General 
(pair_info_count.cpp       : 220)   Edge pairs: 2
   0:00:04.523   273M / 5186M INFO    General 
(pair_info_count.cpp       : 222)   1636 paired reads (79.6495% of all) 
aligned to long edges
   0:00:04.523     1M / 5186M INFO    General 
(pair_info_count.cpp       : 369)     Insert size = 214.696, deviation = 
10.4821, left quantile = 201, right quantile = 228, read length = 100
   0:00:04.524     1M / 5186M INFO    General 
(pair_info_count.cpp       : 390)   Filtering data for library #0
   0:00:04.525     1M / 5186M INFO    General 
(pair_info_count.cpp       :  48)   Selecting usual mapper
   0:00:04.526     1M / 5186M INFO    General 
(sequence_mapper_notifier.h:  95)   Total 2054 reads processed
   0:00:04.526     1M / 5186M INFO    General 
(pair_info_count.cpp       : 402)   Mapping library #0
   0:00:04.526     1M / 5186M INFO    General 
(pair_info_count.cpp       : 404)   Mapping paired reads (takes a while)
   0:00:04.526     1M / 5186M INFO    General 
(pair_info_count.cpp       : 299)   Left insert size quantile 201, right 
insert size quantile 228, filtering threshold 2, rounding threshold 0
   0:00:04.533    10M / 5186M INFO    General 
(pair_info_count.cpp       :  48)   Selecting usual mapper
   0:00:04.538    10M / 5186M INFO    General 
(sequence_mapper_notifier.h:  95)   Total 2054 reads processed
   0:00:04.543     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Distance Estimation (id: 
distance_estimation)
   0:00:04.543     1M / 5186M INFO    General 
(distance_estimation.cpp   : 179)   Processing library #0
   0:00:04.543     1M / 5186M INFO    General 
(distance_estimation.cpp   : 150)   Weight Filter Done
   0:00:04.543     1M / 5186M INFO   DistanceEstimator 
(distance_estimation.hpp   : 116)   Using SIMPLE distance estimator
   0:00:04.544     1M / 5186M INFO    General 
(distance_estimation.cpp   :  37)   Filtering info
   0:00:04.544     1M / 5186M INFO    General 
(pair_info_filters.hpp     : 242)   Start filtering; library index size: 2
   0:00:04.544     1M / 5186M INFO    General 
(pair_info_filters.hpp     : 263)   Done filtering; library index size: 2
   0:00:04.544     1M / 5186M INFO    General 
(distance_estimation.cpp   : 156)   Refining clustered pair information
   0:00:04.544     1M / 5186M INFO    General 
(distance_estimation.cpp   : 158)   The refining of clustered pair 
information has been finished
   0:00:04.544     1M / 5186M INFO    General 
(distance_estimation.cpp   : 160)   Improving paired information
   0:00:04.544     1M / 5186M INFO   PairInfoImprover 
(pair_info_improver.hpp    : 104)   Paired info stats: missing = 0; 
contradictional = 0
   0:00:04.544     1M / 5186M INFO   PairInfoImprover 
(pair_info_improver.hpp    : 104)   Paired info stats: missing = 0; 
contradictional = 0
   0:00:04.544     1M / 5186M INFO    General 
(distance_estimation.cpp   : 104)   Filling scaffolding index
   0:00:04.544     1M / 5186M INFO   DistanceEstimator 
(distance_estimation.hpp   : 116)   Using SMOOTHING distance estimator
   0:00:04.544     1M / 5186M INFO    General 
(distance_estimation.cpp   :  37)   Filtering info
   0:00:04.544     1M / 5186M INFO    General 
(pair_info_filters.hpp     : 242)   Start filtering; library index size: 2
   0:00:04.544     1M / 5186M INFO    General 
(pair_info_filters.hpp     : 263)   Done filtering; library index size: 2
   0:00:04.544     1M / 5186M INFO    General 
(distance_estimation.cpp   : 186)   Clearing raw paired index
   0:00:04.544     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Repeat Resolving (id: repeat_resolving)
   0:00:04.544     1M / 5186M INFO    General 
(repeat_resolving.cpp      :  87)   Using Path-Extend repeat resolving
   0:00:04.544     1M / 5186M INFO    General 
(launcher.cpp              : 600)   ExSPAnder repeat resolving tool started
   0:00:04.545     1M / 5186M INFO    General 
(coverage_uniformity_analyz:  25)   genomic coverage is 140.62 
calculated of length 945
   0:00:04.545     1M / 5186M WARN    General 
(launcher.cpp              : 178)   Your data seems to have high uniform 
coverage depth. It is strongly recommended to use --isolate option.
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 418)   Creating main extenders, unique edge 
length = 2000
   0:00:04.545     1M / 5186M INFO    General 
(extenders_logic.cpp       : 334)   Estimated coverage of library #0 is 
140.62
   0:00:04.545     1M / 5186M INFO    General 
(extenders_logic.cpp       : 345)   Creating extender; library index size: 2
   0:00:04.545     1M / 5186M INFO    General 
(extenders_logic.cpp       : 334)   Estimated coverage of library #0 is 
140.62
   0:00:04.545     1M / 5186M INFO    General 
(extenders_logic.cpp       : 345)   Creating extender; library index size: 2
   0:00:04.545     1M / 5186M INFO    General 
(extenders_logic.cpp       : 543)   Using 1 paired-end library
   0:00:04.545     1M / 5186M INFO    General 
(extenders_logic.cpp       : 544)   Using 1 paired-end scaffolding library
   0:00:04.545     1M / 5186M INFO    General 
(extenders_logic.cpp       : 545)   Using 0 single read libraries
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 447)   Total number of extenders is 3
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 250)   Finalizing paths
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 252)   Deduplicating paths
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 256)   Paths deduplicated
   0:00:04.545     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  60)   Removing overlaps
   0:00:04.545     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  63)   Sorting paths
   0:00:04.545     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  70)   Marking overlaps
   0:00:04.545     1M / 5186M INFO   OverlapRemover 
(overlap_remover.hpp       : 116)   Marking start/end overlaps
   0:00:04.545     1M / 5186M INFO   OverlapRemover 
(overlap_remover.hpp       : 119)   Marking remaining overlaps
   0:00:04.545     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  73)   Splitting paths
   0:00:04.545     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  78)   Deduplicating paths
   0:00:04.545     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  80)   Overlaps removed
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 273)   Paths finalized
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 454)   Closing gaps in paths
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 484)   Gap closing completed
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 302)   Traversing tandem repeats
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 312)   Traversed 0 loops
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 250)   Finalizing paths
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 252)   Deduplicating paths
   0:00:04.545     1M / 5186M INFO    General 
(launcher.cpp              : 256)   Paths deduplicated
   0:00:04.545     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  60)   Removing overlaps
   0:00:04.545     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  63)   Sorting paths
   0:00:04.546     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  70)   Marking overlaps
   0:00:04.546     1M / 5186M INFO   OverlapRemover 
(overlap_remover.hpp       : 116)   Marking start/end overlaps
   0:00:04.546     1M / 5186M INFO   OverlapRemover 
(overlap_remover.hpp       : 119)   Marking remaining overlaps
   0:00:04.546     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  73)   Splitting paths
   0:00:04.546     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  78)   Deduplicating paths
   0:00:04.546     1M / 5186M INFO   PEResolver 
(pe_resolver.cpp           :  80)   Overlaps removed
   0:00:04.546     1M / 5186M INFO    General 
(launcher.cpp              : 273)   Paths finalized
   0:00:04.546     1M / 5186M INFO    General 
(launcher.cpp              : 664)   ExSPAnder repeat resolving tool finished
   0:00:04.546     1M / 5186M INFO   StageManager             (stage.cpp 
                 : 185)   STAGE == Contig Output (id: contig_output)
   0:00:04.546     1M / 5186M INFO    General 
(contig_output.hpp         :  16)   Outputting contigs to 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/before_rr.fasta
   0:00:04.546     1M / 5186M INFO    General 
(contig_output_stage.cpp   : 151)   Writing GFA graph to 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/assembly_graph_with_scaffolds.gfa
   0:00:04.546     1M / 5186M INFO    General 
(contig_output_stage.cpp   : 165)   Outputting FastG graph to 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/assembly_graph.fastg
   0:00:04.546     1M / 5186M INFO    General 
(contig_output_stage.cpp   : 196)   Breaking scaffolds
   0:00:04.546     1M / 5186M INFO    General 
(contig_output_stage.cpp   :  98)   Outputting contigs to 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/final_contigs.fasta
   0:00:04.546     1M / 5186M INFO    General 
(contig_output_stage.cpp   : 104)   Outputting FastG paths to 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/final_contigs.paths
   0:00:04.546     1M / 5186M INFO    General 
(contig_output_stage.cpp   :  98)   Outputting contigs to 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/scaffolds.fasta
   0:00:04.546     1M / 5186M INFO    General 
(contig_output_stage.cpp   : 104)   Outputting FastG paths to 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/scaffolds.paths
   0:00:04.546     1M / 5186M INFO    General 
(contig_output_stage.cpp   : 111)   Populating GFA with scaffold paths
   0:00:04.546     1M / 5186M INFO    General 
(pipeline.cpp              : 287)   SPAdes finished
   0:00:04.547     1M / 5186M INFO    General                 (main.cpp 
                  : 136)   Assembling time: 0 hours 0 minutes 4 seconds

===== K55 finished.

===== Copy files started.

== Running: /usr/bin/python3 
/usr/share/spades/spades_pipeline/scripts/copy_files.py 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/before_rr.fasta 
/tmp/tmp.Kw3upbPyKH/spades_test/before_rr.fasta 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/assembly_graph_after_simplification.gfa 
/tmp/tmp.Kw3upbPyKH/spades_test/assembly_graph_after_simplification.gfa 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/final_contigs.fasta 
/tmp/tmp.Kw3upbPyKH/spades_test/contigs.fasta 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/first_pe_contigs.fasta 
/tmp/tmp.Kw3upbPyKH/spades_test/first_pe_contigs.fasta 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/strain_graph.gfa 
/tmp/tmp.Kw3upbPyKH/spades_test/strain_graph.gfa 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/scaffolds.fasta 
/tmp/tmp.Kw3upbPyKH/spades_test/scaffolds.fasta 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/scaffolds.paths 
/tmp/tmp.Kw3upbPyKH/spades_test/scaffolds.paths 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/assembly_graph_with_scaffolds.gfa 
/tmp/tmp.Kw3upbPyKH/spades_test/assembly_graph_with_scaffolds.gfa 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/assembly_graph.fastg 
/tmp/tmp.Kw3upbPyKH/spades_test/assembly_graph.fastg 
/tmp/tmp.Kw3upbPyKH/spades_test/K55/final_contigs.paths 
/tmp/tmp.Kw3upbPyKH/spades_test/contigs.paths


===== Copy files finished.

===== Assembling finished.

===== Check test started.

== Running: /usr/bin/python3 
/usr/share/spades/spades_pipeline/scripts/check_test_script.py --mode 
common --result_contigs_filename 
/tmp/tmp.Kw3upbPyKH/spades_test/contigs.fasta 
--result_scaffolds_filename /tmp/tmp.Kw3upbPyKH/spades_test/scaffolds.fasta

========= TEST PASSED CORRECTLY.

===== Check test finished.

===== Breaking scaffolds started.

== Running: /usr/bin/python3 
/usr/share/spades/spades_pipeline/scripts/breaking_scaffolds_script.py 
--result_scaffolds_filename 
/tmp/tmp.Kw3upbPyKH/spades_test/scaffolds.fasta --misc_dir 
/tmp/tmp.Kw3upbPyKH/spades_test/misc --threshold_for_breaking_scaffolds 3


===== Breaking scaffolds finished.

===== Terminate started.

===== Terminate finished.
  * Corrected reads are in /tmp/tmp.Kw3upbPyKH/spades_test/corrected/
  * Assembled contigs are in /tmp/tmp.Kw3upbPyKH/spades_test/contigs.fasta
  * Assembled scaffolds are in 
/tmp/tmp.Kw3upbPyKH/spades_test/scaffolds.fasta
  * Paths in the assembly graph corresponding to the contigs are in 
/tmp/tmp.Kw3upbPyKH/spades_test/contigs.paths
  * Paths in the assembly graph corresponding to the scaffolds are in 
/tmp/tmp.Kw3upbPyKH/spades_test/scaffolds.paths
  * Assembly graph is in 
/tmp/tmp.Kw3upbPyKH/spades_test/assembly_graph.fastg
  * Assembly graph in GFA format is in 
/tmp/tmp.Kw3upbPyKH/spades_test/assembly_graph_with_scaffolds.gfa

======= SPAdes pipeline finished WITH WARNINGS!

=== Error correction and assembling warnings:
  * 0:00:04.545     1M / 5186M WARN    General 
(launcher.cpp              : 178)   Your data seems to have high uniform 
coverage depth. It is strongly recommended to use --isolate option.
======= Warnings saved to /tmp/tmp.Kw3upbPyKH/spades_test/warnings.log

SPAdes log can be found here: /tmp/tmp.Kw3upbPyKH/spades_test/spades.log

Thank you for using SPAdes!
WARNING: TruSPAdes is deprecated since version 3.15
Generating truseq dataset from input directories:
	/usr/share/spades/test_dataset_truspades
Printing dataset to /tmp/tmp.Kw3upbPyKH/spades_test_truspades/dataset.info
Dataset generated. See result in 
/tmp/tmp.Kw3upbPyKH/spades_test_truspades/dataset.info
Launching truSPAdes assembly in 8 threads
You can find logs for separate barcodes in 
/tmp/tmp.Kw3upbPyKH/spades_test_truspades/logs
Starting: BC_B
Starting: BC_A
Failed to finish: BC_A
Failed to finish: BC_B
2 barcodes failed to assemble
Warning: could not find assembly results for barcode BC_A
Warning: could not find assembly results for barcode BC_B
Assembled virtual long TruSeq reads can be found in 
/tmp/tmp.Kw3upbPyKH/spades_test_truspades/TSLR.fasta
TruSPAdes launch successfully finished
TruSPAdes test launch failed: incorrect output files
autopkgtest [22:17:38]: test run-upstreams-tests

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